locus-tag	class	description
SAP2_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SAP2_RS00010	COG0592	DNA-directed DNA polymerase activity
SAP2_RS00015	COG2501	S4 domain
SAP2_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SAP2_RS00025	COG0187	DNA topoisomerase II activity
SAP2_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SAP2_RS00045	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SAP2_RS00050	COG2986	histidine ammonia-lyase
SAP2_RS00055	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SAP2_RS00070	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SAP2_RS00080	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
SAP2_RS00085	COG0359	binds to the 23S rRNA
SAP2_RS00090	COG0305	Participates in initiation and elongation during chromosome replication
SAP2_RS00095	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SAP2_RS00115	COG0477	Major facilitator Superfamily
SAP2_RS00120	COG0745	RESPONSE REGULATOR receiver
SAP2_RS00125	COG5002	protein histidine kinase activity
SAP2_RS00140	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SAP2_RS00145	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SAP2_RS00160	COG0693	protein deglycase activity
SAP2_RS00170	COG2249	NAD(P)H dehydrogenase (quinone) activity
SAP2_RS00230	COG0732	type I restriction modification DNA specificity domain
SAP2_RS00240	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SAP2_RS00260	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SAP2_RS00265	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SAP2_RS00265	COG0463	Glycosyl transferase, family 2
SAP2_RS00280	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SAP2_RS00370	COG4975	Glucose uptake
SAP2_RS00390	COG0789	Transcriptional regulator
SAP2_RS00400	COG0702	epimerase
SAP2_RS00415	COG0702	epimerase
SAP2_RS00420	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
SAP2_RS00455	COG0415	Belongs to the DNA photolyase family
SAP2_RS00515	COG2003	Belongs to the UPF0758 family
SAP2_RS00530	COG0579	oxidoreductase
SAP2_RS00535	COG0028	Belongs to the TPP enzyme family
SAP2_RS00540	COG3527	Alpha-acetolactate decarboxylase
SAP2_RS00545	COG1620	l-lactate permease
SAP2_RS00560	COG0415	Belongs to the DNA photolyase family
SAP2_RS00570	COG1959	2 iron, 2 sulfur cluster binding
SAP2_RS00575	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SAP2_RS00580	COG2910	NAD(P)H-binding
SAP2_RS00600	COG0640	Transcriptional regulator
SAP2_RS00605	COG1028	Short-chain dehydrogenase reductase Sdr
SAP2_RS00610	COG0583	DNA-binding transcription factor activity
SAP2_RS00620	COG0010	Belongs to the arginase family
SAP2_RS00645	COG0640	Transcriptional regulator
SAP2_RS00675	COG1132	(ABC) transporter
SAP2_RS00690	COG0471	metal ion transport
SAP2_RS00715	COG1695	Transcriptional regulator
SAP2_RS00725	COG2217	Heavy metal translocating P-type atpase
SAP2_RS00730	COG1388	LysM domain
SAP2_RS00750	COG3226	Transcriptional regulator
SAP2_RS00760	COG0789	Transcriptional regulator
SAP2_RS00795	COG0659	secondary active sulfate transmembrane transporter activity
SAP2_RS00800	COG0589	response to stress
SAP2_RS00805	COG0730	response to heat
SAP2_RS00810	COG1937	Protein conserved in bacteria
SAP2_RS00815	COG2210	Belongs to the sulfur carrier protein TusA family
SAP2_RS00820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SAP2_RS00835	COG0191	fructose-bisphosphate aldolase activity
SAP2_RS00840	COG1942	4-Oxalocrotonate Tautomerase
SAP2_RS00870	COG0492	ferredoxin-NADP+ reductase activity
SAP2_RS00875	COG1959	2 iron, 2 sulfur cluster binding
SAP2_RS00925	COG1309	transcriptional regulator
SAP2_RS00945	COG1131	(ABC) transporter
SAP2_RS00955	COG1476	TRANSCRIPTIONal
SAP2_RS00970	COG1755	Isoprenylcysteine carboxyl methyltransferase
SAP2_RS00980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SAP2_RS00985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SAP2_RS00990	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SAP2_RS01000	COG2423	ornithine cyclodeaminase activity
SAP2_RS01005	COG4264	IucA IucC family
SAP2_RS01010	COG2814	Major facilitator Superfamily
SAP2_RS01015	COG4264	IucA IucC family
SAP2_RS01020	COG4264	IucA IucC family
SAP2_RS01030	COG0019	diaminopimelate decarboxylase activity
SAP2_RS01035	COG1475	DNA binding
SAP2_RS01050	COG3314	Sporulation integral membrane protein YlbJ
SAP2_RS01055	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SAP2_RS01060	COG1028	Short-chain dehydrogenase reductase Sdr
SAP2_RS01065	COG2318	DinB family
SAP2_RS01075	COG1388	LysM domain
SAP2_RS01080	COG3949	Membrane
SAP2_RS01090	COG1388	LysM domain
SAP2_RS01095	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SAP2_RS01100	COG3386	PFAM SMP-30 Gluconolaconase
SAP2_RS01110	COG1054	Belongs to the UPF0176 family
SAP2_RS01115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAP2_RS01120	COG1028	Short-chain dehydrogenase reductase Sdr
SAP2_RS01145	COG2508	Transcriptional regulator
SAP2_RS01150	COG1953	Uracil, thiamine, allantoin
SAP2_RS01160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SAP2_RS01170	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SAP2_RS01175	COG3257	ureidoglycine aminohydrolase activity
SAP2_RS01180	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
SAP2_RS01185	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
SAP2_RS01190	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SAP2_RS01195	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SAP2_RS01210	COG2807	transmembrane transport
SAP2_RS01215	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SAP2_RS01225	COG2832	Protein of unknown function (DUF454)
SAP2_RS01235	COG0730	response to heat
SAP2_RS01240	COG0564	pseudouridine synthase activity
SAP2_RS01245	COG0668	transmembrane transport
SAP2_RS01250	COG2207	Transcriptional regulator
SAP2_RS01255	COG2211	Major facilitator Superfamily
SAP2_RS01260	COG3250	beta-galactosidase activity
SAP2_RS01265	COG0463	Glycosyl transferase, family 2
SAP2_RS01280	COG2610	gluconate transmembrane transporter activity
SAP2_RS01285	COG1131	(ABC) transporter
SAP2_RS01315	COG0129	dihydroxy-acid dehydratase activity
SAP2_RS01320	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SAP2_RS01320	COG0463	Glycosyl transferase, family 2
SAP2_RS01325	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SAP2_RS01330	COG1819	glycosyl
SAP2_RS01335	COG0183	Belongs to the thiolase family
SAP2_RS01340	COG1024	Enoyl-CoA hydratase
SAP2_RS01340	COG1250	3-hydroxyacyl-CoA dehydrogenase
SAP2_RS01345	COG1960	acyl-CoA dehydrogenase activity
SAP2_RS01350	COG0318	PFAM AMP-dependent synthetase and ligase
SAP2_RS01360	COG0579	oxidoreductase
SAP2_RS01370	COG0431	NADPH-dependent FMN reductase
SAP2_RS01380	COG0346	lactoylglutathione lyase activity
SAP2_RS01385	COG0583	DNA-binding transcription factor activity
SAP2_RS01405	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SAP2_RS01410	COG3002	Belongs to the UPF0753 family
SAP2_RS01415	COG5609	conserved protein (DUF2294)
SAP2_RS01420	COG1012	belongs to the aldehyde dehydrogenase family
SAP2_RS01425	COG0477	Major facilitator Superfamily
SAP2_RS01435	COG2814	Major facilitator Superfamily
SAP2_RS01440	COG0583	DNA-binding transcription factor activity
SAP2_RS01445	COG0175	sulfate reduction
SAP2_RS01450	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SAP2_RS01455	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SAP2_RS01475	COG0730	response to heat
SAP2_RS01480	COG2046	Belongs to the sulfate adenylyltransferase family
SAP2_RS01485	COG0529	Catalyzes the synthesis of activated sulfate
SAP2_RS01490	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SAP2_RS01505	COG4975	Glucose uptake
SAP2_RS01510	COG1869	D-ribose catabolic process
SAP2_RS01520	COG2040	homocysteine
SAP2_RS01525	COG0833	amino acid
SAP2_RS01530	COG0772	Belongs to the SEDS family
SAP2_RS01540	COG1316	TRANSCRIPTIONal
SAP2_RS01545	COG0730	response to heat
SAP2_RS01550	COG0778	Nitroreductase
SAP2_RS01555	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SAP2_RS01560	COG1473	amidohydrolase
SAP2_RS01565	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
SAP2_RS01570	COG1691	(AIR) carboxylase
SAP2_RS01575	COG1606	tRNA processing
SAP2_RS01580	COG3875	lactate racemase activity
SAP2_RS01585	COG1072	(Pantothenic acid kinase))
SAP2_RS01590	COG1609	Transcriptional regulator
SAP2_RS01600	COG0235	Class ii aldolase
SAP2_RS01605	COG2160	L-arabinose isomerase activity
SAP2_RS01615	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SAP2_RS01615	COG0574	Belongs to the PEP-utilizing enzyme family
SAP2_RS01620	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SAP2_RS01630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SAP2_RS01635	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SAP2_RS01640	COG1012	belongs to the aldehyde dehydrogenase family
SAP2_RS01645	COG0531	amino acid
SAP2_RS01665	COG0673	inositol 2-dehydrogenase activity
SAP2_RS01680	COG1510	regulation of RNA biosynthetic process
SAP2_RS01685	COG1012	belongs to the aldehyde dehydrogenase family
SAP2_RS01690	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SAP2_RS01700	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SAP2_RS01715	COG2843	Capsule synthesis protein
SAP2_RS01730	COG0531	amino acid
SAP2_RS01735	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SAP2_RS01740	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SAP2_RS01745	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SAP2_RS01750	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SAP2_RS01755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SAP2_RS01760	COG1070	Carbohydrate kinase
SAP2_RS01770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SAP2_RS01780	COG2022	thiamine diphosphate biosynthetic process
SAP2_RS01785	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SAP2_RS01790	COG2814	Major facilitator Superfamily
SAP2_RS01805	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SAP2_RS01810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SAP2_RS01815	COG0765	amino acid transport
SAP2_RS01820	COG1126	abc transporter atp-binding protein
SAP2_RS01830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SAP2_RS01840	COG3037	sugar-specific permease SgaT UlaA
SAP2_RS01845	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SAP2_RS01855	COG1131	(ABC) transporter
SAP2_RS01860	COG1309	transcriptional regulator
SAP2_RS01865	COG1482	cell wall glycoprotein biosynthetic process
SAP2_RS01870	COG1940	carbohydrate kinase activity
SAP2_RS01890	COG2271	Major facilitator Superfamily
SAP2_RS01910	COG1309	transcriptional regulator
SAP2_RS01925	COG0829	nickel cation binding
SAP2_RS01950	COG0561	phosphatase activity
SAP2_RS01960	COG0167	dihydroorotate dehydrogenase activity
SAP2_RS01965	COG3001	Fructosamine kinase
SAP2_RS01990	COG0697	spore germination
SAP2_RS01995	COG1113	amino acid transport
SAP2_RS02000	COG1957	nucleoside hydrolase
SAP2_RS02015	COG3189	MarR family transcriptional regulator
SAP2_RS02035	COG1388	LysM domain
SAP2_RS02045	COG2608	mercury ion transmembrane transporter activity
SAP2_RS02050	COG2217	Heavy metal translocating P-type atpase
SAP2_RS02060	COG1136	(ABC) transporter
SAP2_RS02065	COG0577	efflux transmembrane transporter activity
SAP2_RS02080	COG0471	metal ion transport
SAP2_RS02085	COG5505	Protein of unknown function (DUF819)
SAP2_RS02100	COG4336	lyase activity
SAP2_RS02110	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
SAP2_RS02115	COG1012	belongs to the aldehyde dehydrogenase family
SAP2_RS02125	COG2409	Drug exporters of the RND superfamily
SAP2_RS02130	COG1473	amidohydrolase
SAP2_RS02140	COG3961	Belongs to the TPP enzyme family
SAP2_RS02155	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SAP2_RS02160	COG3425	synthase
SAP2_RS02165	COG0183	Belongs to the thiolase family
SAP2_RS02175	COG1757	Na H antiporter
SAP2_RS02185	COG0583	DNA-binding transcription factor activity
SAP2_RS02190	COG1380	Effector of murein hydrolase LrgA
SAP2_RS02200	COG0028	Belongs to the TPP enzyme family
SAP2_RS02205	COG1288	antiporter activity
SAP2_RS02230	COG0657	acetylesterase activity
SAP2_RS02235	COG0697	spore germination
SAP2_RS02240	COG2207	Transcriptional regulator
SAP2_RS02255	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SAP2_RS02265	COG2843	Capsule synthesis protein
SAP2_RS02275	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SAP2_RS02280	COG1063	alcohol dehydrogenase
SAP2_RS02285	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SAP2_RS02310	COG2084	Dehydrogenase
SAP2_RS02320	COG2610	gluconate transmembrane transporter activity
SAP2_RS02330	COG3764	Sortase (surface protein transpeptidase)
SAP2_RS02335	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SAP2_RS02340	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SAP2_RS02340	COG0517	IMP dehydrogenase activity
SAP2_RS02345	COG1940	carbohydrate kinase activity
SAP2_RS02350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SAP2_RS02355	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SAP2_RS02360	COG2249	NAD(P)H dehydrogenase (quinone) activity
SAP2_RS02365	COG0561	phosphatase activity
SAP2_RS02370	COG0778	Nitroreductase
SAP2_RS02375	COG2514	catechol 2,3-dioxygenase activity
SAP2_RS02380	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SAP2_RS02385	COG1132	(ABC) transporter
SAP2_RS02390	COG1132	(ABC) transporter
SAP2_RS02405	COG1012	belongs to the aldehyde dehydrogenase family
SAP2_RS02410	COG1846	Transcriptional regulator
SAP2_RS02415	COG0346	lactoylglutathione lyase activity
SAP2_RS02420	COG0346	lactoylglutathione lyase activity
SAP2_RS02425	COG0400	carboxylic ester hydrolase activity
SAP2_RS02435	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
SAP2_RS02440	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SAP2_RS02445	COG0586	Pfam SNARE associated Golgi protein
SAP2_RS02450	COG2271	Major facilitator Superfamily
SAP2_RS02455	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
SAP2_RS02460	COG3527	Alpha-acetolactate decarboxylase
SAP2_RS02465	COG1289	transmembrane transporter activity
SAP2_RS02470	COG4876	unkown
SAP2_RS02475	COG2357	RelA SpoT domain protein
SAP2_RS02480	COG1802	Transcriptional regulator
SAP2_RS02490	COG2610	gluconate transmembrane transporter activity
SAP2_RS02495	COG3949	Membrane
SAP2_RS02505	COG2211	Major facilitator Superfamily
SAP2_RS02510	COG3250	beta-galactosidase activity
SAP2_RS02525	COG4221	oxidoreductase activity
SAP2_RS02540	COG0107	imidazoleglycerol-phosphate synthase activity
SAP2_RS02545	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SAP2_RS02550	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SAP2_RS02560	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SAP2_RS02565	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SAP2_RS02570	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SAP2_RS02575	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SAP2_RS02580	COG3048	D-serine ammonia-lyase activity
SAP2_RS02585	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SAP2_RS02595	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
SAP2_RS02600	COG1473	amidohydrolase
SAP2_RS02605	COG1363	Peptidase, m42
SAP2_RS02615	COG0069	glutamate synthase activity
SAP2_RS02625	COG4619	ABC transporter
SAP2_RS02630	COG0390	transport system, permease component
SAP2_RS02635	COG2814	Major facilitator Superfamily
SAP2_RS02645	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
SAP2_RS02655	COG3246	L-lysine catabolic process to acetate
SAP2_RS02660	COG1250	3-hydroxyacyl-CoA dehydrogenase
SAP2_RS02695	COG1960	acyl-CoA dehydrogenase activity
SAP2_RS02700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SAP2_RS02710	COG1116	anion transmembrane transporter activity
SAP2_RS02755	COG2814	Major facilitator Superfamily
SAP2_RS02760	COG1929	Belongs to the glycerate kinase type-1 family
SAP2_RS02770	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SAP2_RS02775	COG0741	lytic transglycosylase activity
SAP2_RS02780	COG0588	phosphoglycerate mutase activity
SAP2_RS02785	COG2814	Major facilitator Superfamily
SAP2_RS02810	COG2353	YceI-like domain
SAP2_RS02830	COG2723	6-phospho-beta-galactosidase activity
SAP2_RS02835	COG2190	(PTS) system
SAP2_RS02835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SAP2_RS02835	COG1263	PTS System
SAP2_RS02840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SAP2_RS02850	COG2116	formate transmembrane transporter activity
SAP2_RS02855	COG0454	-acetyltransferase
SAP2_RS02870	COG1846	Transcriptional regulator
SAP2_RS02885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SAP2_RS02885	COG1263	PTS System
SAP2_RS02900	COG1283	sodium-dependent phosphate transmembrane transporter activity
SAP2_RS02905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAP2_RS02910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAP2_RS02915	COG1288	antiporter activity
SAP2_RS02920	COG1349	DNA-binding transcription factor activity
SAP2_RS02925	COG1063	alcohol dehydrogenase
SAP2_RS02930	COG2376	Dihydroxyacetone kinase
SAP2_RS02940	COG0698	ribose 5-phosphate isomerase
SAP2_RS02960	COG0492	ferredoxin-NADP+ reductase activity
SAP2_RS02970	COG2814	Major facilitator Superfamily
SAP2_RS02975	COG0604	alcohol dehydrogenase
SAP2_RS02990	COG0463	Glycosyl transferase, family 2
SAP2_RS02990	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SAP2_RS02995	COG0438	transferase activity, transferring glycosyl groups
SAP2_RS03005	COG5002	protein histidine kinase activity
SAP2_RS03005	COG3850	Histidine kinase
SAP2_RS03010	COG0745	RESPONSE REGULATOR receiver
SAP2_RS03015	COG0577	efflux transmembrane transporter activity
SAP2_RS03020	COG1136	(ABC) transporter
SAP2_RS03035	COG1033	growth of symbiont in host cell
SAP2_RS03035	COG2409	Drug exporters of the RND superfamily
SAP2_RS03040	COG4640	response to antibiotic
SAP2_RS03045	COG2814	Major facilitator Superfamily
SAP2_RS03055	COG1566	PFAM secretion protein HlyD family protein
SAP2_RS03060	COG2814	Major facilitator Superfamily
SAP2_RS03090	COG0598	Magnesium transport protein CorA
SAP2_RS03095	COG1304	FMN binding
SAP2_RS03100	COG2094	Belongs to the DNA glycosylase MPG family
SAP2_RS03105	COG3152	Membrane
SAP2_RS03110	COG4152	abc transporter atp-binding protein
SAP2_RS03115	COG1668	transmembrane transport
SAP2_RS03120	COG2017	converts alpha-aldose to the beta-anomer
SAP2_RS03125	COG2258	MOSC domain
SAP2_RS03130	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SAP2_RS03135	COG1266	CAAX protease self-immunity
SAP2_RS03140	COG0010	Belongs to the arginase family
SAP2_RS03145	COG0583	DNA-binding transcription factor activity
SAP2_RS03150	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SAP2_RS03155	COG1228	amidohydrolase
SAP2_RS03160	COG1473	amidohydrolase
SAP2_RS03165	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SAP2_RS03185	COG1263	PTS System
SAP2_RS03185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SAP2_RS03200	COG0385	Bile acid
SAP2_RS03205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SAP2_RS03225	COG1113	amino acid transport
SAP2_RS03230	COG1785	Belongs to the alkaline phosphatase family
SAP2_RS03240	COG1737	Transcriptional regulator
SAP2_RS03245	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SAP2_RS03245	COG1263	PTS System
SAP2_RS03250	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SAP2_RS03275	COG1316	TRANSCRIPTIONal
SAP2_RS03280	COG3383	formate dehydrogenase (NAD+) activity
SAP2_RS03305	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SAP2_RS03310	COG2076	Multidrug Resistance protein
SAP2_RS03315	COG2076	Multidrug Resistance protein
SAP2_RS03320	COG3942	CHAP domain
SAP2_RS03335	COG1757	Na H antiporter
SAP2_RS03340	COG3942	CHAP domain
SAP2_RS03370	COG0765	amino acid transport
SAP2_RS03375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SAP2_RS03380	COG1126	abc transporter atp-binding protein
SAP2_RS03385	COG1960	acyl-CoA dehydrogenase activity
SAP2_RS03390	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SAP2_RS03395	COG1268	BioY protein
SAP2_RS03405	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SAP2_RS03410	COG1609	Transcriptional regulator
SAP2_RS03415	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SAP2_RS03420	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SAP2_RS03425	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SAP2_RS03430	COG0725	ABC transporter, periplasmic molybdate-binding protein
SAP2_RS03435	COG4149	molybdate abc transporter
SAP2_RS03440	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
SAP2_RS03445	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SAP2_RS03450	COG0521	Mo-molybdopterin cofactor biosynthetic process
SAP2_RS03455	COG0315	cyclic pyranopterin monophosphate synthase activity
SAP2_RS03465	COG1763	Mo-molybdopterin cofactor biosynthetic process
SAP2_RS03470	COG0314	molybdopterin synthase activity
SAP2_RS03480	COG0746	molybdenum cofactor guanylyltransferase activity
SAP2_RS03485	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SAP2_RS03495	COG2814	Major facilitator Superfamily
SAP2_RS03515	COG2348	transferase activity, transferring amino-acyl groups
SAP2_RS03530	COG1028	Short-chain dehydrogenase reductase Sdr
SAP2_RS03535	COG4975	Glucose uptake
SAP2_RS03545	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SAP2_RS03545	COG0551	DNA topoisomerase type I activity
SAP2_RS03550	COG2252	PERMEase
SAP2_RS03560	COG0051	transcription antitermination factor activity, RNA binding
SAP2_RS03565	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SAP2_RS03570	COG0088	Forms part of the polypeptide exit tunnel
SAP2_RS03575	COG0089	rRNA binding
SAP2_RS03580	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SAP2_RS03585	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SAP2_RS03590	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SAP2_RS03595	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SAP2_RS03600	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SAP2_RS03605	COG0255	Belongs to the universal ribosomal protein uL29 family
SAP2_RS03610	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SAP2_RS03615	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SAP2_RS03620	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SAP2_RS03625	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SAP2_RS03630	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SAP2_RS03635	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SAP2_RS03640	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SAP2_RS03645	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SAP2_RS03650	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SAP2_RS03655	COG1841	ribosomal large subunit assembly
SAP2_RS03665	COG0201	protein transport
SAP2_RS03670	COG0563	adenylate kinase activity
SAP2_RS03680	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SAP2_RS03685	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SAP2_RS03695	COG0202	RNA polymerase activity
SAP2_RS03700	COG0203	ribosomal protein L17
SAP2_RS03705	COG1122	ATPase activity
SAP2_RS03710	COG1122	ATPase activity
SAP2_RS03720	COG0101	tRNA pseudouridine synthase activity
SAP2_RS03725	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SAP2_RS03730	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SAP2_RS03735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAP2_RS03740	COG2130	NADP-dependent
SAP2_RS03745	COG0604	alcohol dehydrogenase
SAP2_RS03750	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SAP2_RS03765	COG1302	Protein conserved in bacteria
SAP2_RS03775	COG4264	IucA IucC family
SAP2_RS03780	COG3457	Alanine racemase
SAP2_RS03785	COG3314	Sporulation integral membrane protein YlbJ
SAP2_RS03790	COG2329	Antibiotic biosynthesis monooxygenase
SAP2_RS03800	COG1988	membrane-bound metal-dependent
SAP2_RS03805	COG4284	Utp--glucose-1-phosphate uridylyltransferase
SAP2_RS03810	COG1272	protein, Hemolysin III
SAP2_RS03830	COG0489	protein tyrosine kinase activity
SAP2_RS03885	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SAP2_RS03895	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SAP2_RS03900	COG0246	Mannitol dehydrogenase
SAP2_RS03910	COG3711	transcriptional antiterminator
SAP2_RS03915	COG2213	PTS system mannitol-specific
SAP2_RS03930	COG1119	ATPase activity
SAP2_RS03955	COG0640	Transcriptional regulator
SAP2_RS03960	COG0702	epimerase
SAP2_RS03965	COG2186	Transcriptional regulator
SAP2_RS03970	COG1482	cell wall glycoprotein biosynthetic process
SAP2_RS03990	COG0783	Belongs to the Dps family
SAP2_RS03995	COG0813	purine-nucleoside phosphorylase activity
SAP2_RS04000	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SAP2_RS04005	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
SAP2_RS04010	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
SAP2_RS04035	COG5146	pantothenate kinase activity
SAP2_RS04050	COG0504	CTP synthase activity
SAP2_RS04060	COG0191	fructose-bisphosphate aldolase activity
SAP2_RS04065	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SAP2_RS04075	COG1012	belongs to the aldehyde dehydrogenase family
SAP2_RS04080	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SAP2_RS04085	COG0254	rRNA binding
SAP2_RS04090	COG1435	thymidine kinase activity
SAP2_RS04095	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SAP2_RS04100	COG2890	protein-(glutamine-N5) methyltransferase activity
SAP2_RS04105	COG0009	L-threonylcarbamoyladenylate synthase
SAP2_RS04110	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SAP2_RS04115	COG4475	Protein of unknown function (DUF436)
SAP2_RS04120	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SAP2_RS04125	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SAP2_RS04130	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SAP2_RS04140	COG0356	it plays a direct role in the translocation of protons across the membrane
SAP2_RS04145	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SAP2_RS04150	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SAP2_RS04155	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SAP2_RS04160	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SAP2_RS04165	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SAP2_RS04170	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SAP2_RS04175	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SAP2_RS04180	COG4836	Membrane
SAP2_RS04185	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SAP2_RS04200	COG0629	single-stranded DNA binding
SAP2_RS04205	COG1388	LysM domain
SAP2_RS04210	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SAP2_RS04220	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
SAP2_RS04225	COG0352	thiamine-phosphate diphosphorylase activity
SAP2_RS04230	COG0706	membrane insertase activity
SAP2_RS04235	COG1418	mRNA catabolic process
SAP2_RS04240	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SAP2_RS04245	COG1937	Protein conserved in bacteria
SAP2_RS04255	COG0772	Belongs to the SEDS family
SAP2_RS04260	COG1181	Belongs to the D-alanine--D-alanine ligase family
SAP2_RS04265	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SAP2_RS04270	COG0513	Belongs to the DEAD box helicase family
SAP2_RS04280	COG3428	Bacterial PH domain
SAP2_RS04290	COG0736	holo-[acyl-carrier-protein] synthase activity
SAP2_RS04295	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SAP2_RS04305	COG2337	Toxic component of a toxin-antitoxin (TA) module
SAP2_RS04310	COG2208	phosphoserine phosphatase activity
SAP2_RS04325	COG1191	sigma factor activity
SAP2_RS04330	COG2183	response to ionizing radiation
SAP2_RS04335	COG3091	SprT-like family
SAP2_RS04365	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SAP2_RS04375	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SAP2_RS04380	COG0473	3-isopropylmalate dehydrogenase activity
SAP2_RS04385	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SAP2_RS04390	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SAP2_RS04395	COG0440	acetolactate synthase activity
SAP2_RS04400	COG0028	Belongs to the TPP enzyme family
SAP2_RS04405	COG0129	dihydroxy-acid dehydratase activity
SAP2_RS04410	COG0802	atpase or kinase
SAP2_RS04415	COG1214	PFAM Peptidase M22, glycoprotease
SAP2_RS04420	COG0456	acetyltransferase
SAP2_RS04425	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SAP2_RS04440	COG0488	(ABC) transporter
SAP2_RS04445	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SAP2_RS04450	COG2391	methyltransferase activity
SAP2_RS04455	COG0425	Belongs to the sulfur carrier protein TusA family
SAP2_RS04460	COG1609	Transcriptional regulator
SAP2_RS04465	COG1621	beta-fructofuranosidase activity
SAP2_RS04470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SAP2_RS04490	COG4512	PFAM Accessory gene regulator B
SAP2_RS04520	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SAP2_RS04525	COG0459	protein refolding
SAP2_RS04550	COG1131	(ABC) transporter
SAP2_RS04590	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SAP2_RS04595	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SAP2_RS04605	COG2706	6-phosphogluconolactonase activity
SAP2_RS04610	COG1012	belongs to the aldehyde dehydrogenase family
SAP2_RS04615	COG1227	inorganic diphosphatase activity
SAP2_RS04620	COG1335	isochorismatase
SAP2_RS04625	COG5434	Belongs to the glycosyl hydrolase 28 family
SAP2_RS04630	COG0471	metal ion transport
SAP2_RS04635	COG0077	Prephenate dehydratase
SAP2_RS04645	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SAP2_RS04650	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SAP2_RS04655	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
SAP2_RS04670	COG4496	protein, YerC YecD
SAP2_RS04675	COG1876	peptidase activity
SAP2_RS04690	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SAP2_RS04695	COG4851	CamS sex pheromone cAM373 precursor
SAP2_RS04700	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SAP2_RS04705	COG0154	amidase activity
SAP2_RS04710	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SAP2_RS04715	COG1597	lipid kinase activity
SAP2_RS04720	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SAP2_RS04730	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SAP2_RS04740	COG1528	Iron-storage protein
SAP2_RS04755	COG4129	membrane
SAP2_RS04760	COG0024	Methionine aminopeptidase
SAP2_RS04780	COG2197	response regulator
SAP2_RS04785	COG1295	ribonuclease BN
SAP2_RS04795	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SAP2_RS04800	COG4840	Belongs to the UPF0435 family
SAP2_RS04805	COG2309	aminopeptidase activity
SAP2_RS04810	COG1607	acyl-coa hydrolase
SAP2_RS04815	COG0535	radical SAM domain protein
SAP2_RS04825	COG0693	protein deglycase activity
SAP2_RS04830	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SAP2_RS04835	COG2137	regulation of response to DNA damage stimulus
SAP2_RS04845	COG1388	LysM domain
SAP2_RS04845	COG1134	teichoic acid transport
SAP2_RS04855	COG1988	membrane-bound metal-dependent
SAP2_RS04860	COG1194	a g-specific adenine glycosylase
SAP2_RS04865	COG3557	Belongs to the UPF0374 family
SAP2_RS04875	COG4129	membrane
SAP2_RS04880	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SAP2_RS04885	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SAP2_RS04890	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SAP2_RS04895	COG0735	belongs to the Fur family
SAP2_RS05060	COG0765	amino acid transport
SAP2_RS05065	COG1126	abc transporter atp-binding protein
SAP2_RS05070	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SAP2_RS05080	COG0363	glucosamine-6-phosphate deaminase activity
SAP2_RS05090	COG0114	fumarate hydratase activity
SAP2_RS05095	COG0564	pseudouridine synthase activity
SAP2_RS05100	COG2203	Gaf domain
SAP2_RS05100	COG4585	Histidine kinase
SAP2_RS05105	COG2197	response regulator
SAP2_RS05115	COG0788	formyltetrahydrofolate deformylase activity
SAP2_RS05125	COG4399	Belongs to the UPF0754 family
SAP2_RS05130	COG3679	Belongs to the UPF0342 family
SAP2_RS05135	COG0420	3'-5' exonuclease activity
SAP2_RS05145	COG3481	metal-dependent phosphohydrolase, HD sub domain
SAP2_RS05150	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SAP2_RS05165	COG0537	adenosine 5'-monophosphoramidase activity
SAP2_RS05170	COG1131	(ABC) transporter
SAP2_RS05175	COG4473	ABC transporter
SAP2_RS05185	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SAP2_RS05190	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SAP2_RS05195	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SAP2_RS05250	COG1280	lysine exporter protein (LysE YggA)
SAP2_RS05320	COG0438	transferase activity, transferring glycosyl groups
SAP2_RS05325	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SAP2_RS05335	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SAP2_RS05340	COG1917	Cupin 2, conserved barrel domain protein
SAP2_RS05340	COG2207	Transcriptional regulator
SAP2_RS05345	COG0318	PFAM AMP-dependent synthetase and ligase
SAP2_RS05355	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SAP2_RS05360	COG0494	nUDIX hydrolase
SAP2_RS05365	COG1506	peptidase
SAP2_RS05375	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
SAP2_RS05380	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SAP2_RS05390	COG0656	L-ascorbic acid biosynthetic process
SAP2_RS05395	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SAP2_RS05410	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SAP2_RS05435	COG4193	domain, Protein
SAP2_RS05435	COG5632	N-Acetylmuramoyl-L-alanine amidase
SAP2_RS05435	COG3266	domain, Protein
SAP2_RS05450	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SAP2_RS05450	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SAP2_RS05455	COG0307	riboflavin synthase, alpha
SAP2_RS05460	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SAP2_RS05460	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SAP2_RS05465	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SAP2_RS05475	COG2267	carboxylic ester hydrolase activity
SAP2_RS05480	COG0039	L-malate dehydrogenase activity
SAP2_RS05490	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SAP2_RS05495	COG1242	4 iron, 4 sulfur cluster binding
SAP2_RS05500	COG2814	Major facilitator Superfamily
SAP2_RS05505	COG0495	leucyl-tRNA aminoacylation
SAP2_RS05515	COG2081	HI0933 family
SAP2_RS05525	COG2244	polysaccharide biosynthetic process
SAP2_RS05530	COG1187	pseudouridine synthase activity
SAP2_RS05540	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SAP2_RS05550	COG0510	thiamine kinase activity
SAP2_RS05555	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SAP2_RS05560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SAP2_RS05565	COG5584	Small secreted protein
SAP2_RS05570	COG1363	Peptidase, m42
SAP2_RS05575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SAP2_RS05580	COG4848	Belongs to the UPF0354 family
SAP2_RS05585	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SAP2_RS05590	COG1674	ftsk spoiiie
SAP2_RS05595	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SAP2_RS05600	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
SAP2_RS05610	COG1605	Chorismate mutase
SAP2_RS05610	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SAP2_RS05615	COG1609	Transcriptional regulator
SAP2_RS05620	COG0123	including yeast histone deacetylase and acetoin utilization protein
SAP2_RS05625	COG0454	-acetyltransferase
SAP2_RS05630	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SAP2_RS05635	COG2759	Belongs to the formate--tetrahydrofolate ligase family
SAP2_RS05640	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SAP2_RS05645	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SAP2_RS05650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SAP2_RS05655	COG0204	Acyl-transferase
SAP2_RS05660	COG1263	PTS System
SAP2_RS05660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SAP2_RS05670	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SAP2_RS05675	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SAP2_RS05680	COG1764	response to oxidative stress
SAP2_RS05685	COG0584	glycerophosphoryl diester phosphodiesterase
SAP2_RS05695	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SAP2_RS05705	COG1956	GAF domain-containing protein
SAP2_RS05710	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
SAP2_RS05715	COG1104	cysteine desulfurase activity
SAP2_RS05720	COG0301	tRNA thio-modification
SAP2_RS05730	COG0616	signal peptide processing
SAP2_RS05735	COG1714	RDD family
SAP2_RS05740	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SAP2_RS05745	COG0827	DNA restriction-modification system
SAP2_RS05750	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SAP2_RS05760	COG0589	response to stress
SAP2_RS05765	COG0686	Belongs to the AlaDH PNT family
SAP2_RS05770	COG3142	Participates in the control of copper homeostasis
SAP2_RS05775	COG0006	proline dipeptidase activity
SAP2_RS05780	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SAP2_RS05790	COG4109	DRTGG domain
SAP2_RS05795	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SAP2_RS05805	COG0281	malic enzyme
SAP2_RS05810	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SAP2_RS05815	COG0825	malonyl-CoA metabolic process
SAP2_RS05820	COG0205	6-phosphofructokinase activity
SAP2_RS05825	COG0469	pyruvate kinase activity
SAP2_RS05835	COG1113	amino acid transport
SAP2_RS05840	COG0372	Belongs to the citrate synthase family
SAP2_RS05845	COG0538	isocitrate dehydrogenase activity
SAP2_RS05850	COG0745	RESPONSE REGULATOR receiver
SAP2_RS05855	COG5002	protein histidine kinase activity
SAP2_RS05860	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SAP2_RS05860	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SAP2_RS05865	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SAP2_RS05870	COG0237	dephospho-CoA kinase activity
SAP2_RS05875	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SAP2_RS05880	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SAP2_RS05885	COG3611	Membrane attachment protein
SAP2_RS05890	COG1484	DNA-dependent DNA replication
SAP2_RS05895	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SAP2_RS05900	COG0833	amino acid
SAP2_RS05905	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SAP2_RS05910	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SAP2_RS05915	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SAP2_RS05920	COG4112	unkown
SAP2_RS05930	COG0544	peptidyl-prolyl cis-trans isomerase activity
SAP2_RS05935	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SAP2_RS05940	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SAP2_RS05945	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SAP2_RS05950	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SAP2_RS05955	COG0181	hydroxymethylbilane synthase activity
SAP2_RS05960	COG1587	Uroporphyrinogen-III synthase
SAP2_RS05965	COG0113	porphobilinogen synthase activity
SAP2_RS05970	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SAP2_RS05980	COG2818	Glycosylase
SAP2_RS05985	COG0525	valine-tRNA ligase activity
SAP2_RS05990	COG0285	dihydrofolate synthase activity
SAP2_RS05995	COG0438	transferase activity, transferring glycosyl groups
SAP2_RS06005	COG2003	Belongs to the UPF0758 family
SAP2_RS06035	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SAP2_RS06050	COG0656	L-ascorbic acid biosynthetic process
SAP2_RS06080	COG1792	Involved in formation and maintenance of cell shape
SAP2_RS06090	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SAP2_RS06095	COG2868	ribosomal protein
SAP2_RS06100	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SAP2_RS06105	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SAP2_RS06110	COG4492	Belongs to the UPF0735 family
SAP2_RS06120	COG2255	four-way junction helicase activity
SAP2_RS06125	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SAP2_RS06130	COG0343	queuine tRNA-ribosyltransferase activity
SAP2_RS06135	COG1862	Preprotein translocase
SAP2_RS06140	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SAP2_RS06140	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SAP2_RS06145	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SAP2_RS06145	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SAP2_RS06155	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SAP2_RS06160	COG1490	D-aminoacyl-tRNA deacylase activity
SAP2_RS06165	COG0860	N-Acetylmuramoyl-L-alanine amidase
SAP2_RS06175	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SAP2_RS06185	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SAP2_RS06190	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SAP2_RS06195	COG1959	2 iron, 2 sulfur cluster binding
SAP2_RS06205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAP2_RS06210	COG0488	(ABC) transporter
SAP2_RS06215	COG1104	cysteine desulfurase activity
SAP2_RS06220	COG0482	sulfurtransferase activity
SAP2_RS06230	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SAP2_RS06235	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SAP2_RS06240	COG4472	Bacterial protein of unknown function (DUF965)
SAP2_RS06245	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SAP2_RS06250	COG3906	Belongs to the UPF0473 family
SAP2_RS06255	COG4122	O-methyltransferase activity
SAP2_RS06260	COG0826	peptidase U32
SAP2_RS06265	COG0826	peptidase U32
SAP2_RS06270	COG0572	uridine kinase
SAP2_RS06275	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SAP2_RS06280	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SAP2_RS06285	COG1984	allophanate hydrolase subunit 2
SAP2_RS06295	COG0439	Biotin carboxylase
SAP2_RS06300	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SAP2_RS06305	COG1914	H( )-stimulated, divalent metal cation uptake system
SAP2_RS06310	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SAP2_RS06315	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SAP2_RS06320	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SAP2_RS06325	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SAP2_RS06330	COG1534	Rna-binding protein
SAP2_RS06335	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SAP2_RS06340	COG1713	HD superfamily hydrolase involved in NAD metabolism
SAP2_RS06345	COG0799	negative regulation of ribosome biogenesis
SAP2_RS06350	COG2226	methyltransferase
SAP2_RS06355	COG1555	photosystem II stabilization
SAP2_RS06355	COG1596	polysaccharide export
SAP2_RS06360	COG2131	deaminase
SAP2_RS06365	COG0658	competence protein
SAP2_RS06365	COG2333	competence protein COMEC
SAP2_RS06370	COG1466	dna polymerase III delta subunit
SAP2_RS06375	COG0268	Binds directly to 16S ribosomal RNA
SAP2_RS06380	COG0481	GTPase activity
SAP2_RS06385	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SAP2_RS06390	COG1420	regulation of RNA biosynthetic process
SAP2_RS06395	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SAP2_RS06400	COG0443	Heat shock 70 kDa protein
SAP2_RS06405	COG0484	heat shock protein binding
SAP2_RS06410	COG2264	protein methyltransferase activity
SAP2_RS06415	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SAP2_RS06420	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SAP2_RS06425	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SAP2_RS06430	COG1030	water channel activity
SAP2_RS06435	COG4864	UPF0365 protein
SAP2_RS06445	COG1702	phosphate starvation-inducible protein PhoH
SAP2_RS06450	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SAP2_RS06460	COG0295	cytidine deaminase activity
SAP2_RS06465	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SAP2_RS06470	COG1381	Involved in DNA repair and RecF pathway recombination
SAP2_RS06475	COG0423	glycine-tRNA ligase activity
SAP2_RS06480	COG0517	IMP dehydrogenase activity
SAP2_RS06485	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SAP2_RS06495	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SAP2_RS06500	COG2384	SAM-dependent methyltransferase
SAP2_RS06510	COG0513	Belongs to the DEAD box helicase family
SAP2_RS06515	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SAP2_RS06520	COG1121	(ABC) transporter
SAP2_RS06525	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SAP2_RS06530	COG0735	belongs to the Fur family
SAP2_RS06535	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SAP2_RS06540	COG0768	penicillin binding
SAP2_RS06545	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SAP2_RS06550	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SAP2_RS06560	COG4483	Protein conserved in bacteria
SAP2_RS06565	COG1940	carbohydrate kinase activity
SAP2_RS06570	COG0011	TIGRFAM Protein of
SAP2_RS06575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SAP2_RS06580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SAP2_RS06610	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SAP2_RS06615	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SAP2_RS06620	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SAP2_RS06625	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SAP2_RS06630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SAP2_RS06635	COG0095	Lipoate-protein ligase
SAP2_RS06650	COG0006	proline dipeptidase activity
SAP2_RS06655	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SAP2_RS06660	COG0511	ligase activity, forming carbon-carbon bonds
SAP2_RS06665	COG0439	Biotin carboxylase
SAP2_RS06675	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SAP2_RS06680	COG1570	exodeoxyribonuclease VII activity
SAP2_RS06695	COG1438	arginine binding
SAP2_RS06700	COG0497	DNA recombination
SAP2_RS06705	COG0280	phosphate acetyltransferase
SAP2_RS06710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SAP2_RS06715	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SAP2_RS06720	COG0022	dehydrogenase e1 component
SAP2_RS06725	COG0508	dehydrogenase complex catalyzes the overall conversion of
SAP2_RS06735	COG4129	membrane
SAP2_RS06740	COG2195	Cleaves the N-terminal amino acid of tripeptides
SAP2_RS06750	COG0366	Alpha amylase catalytic
SAP2_RS06760	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SAP2_RS06765	COG1234	tRNA 3'-trailer cleavage
SAP2_RS06770	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SAP2_RS06775	COG0300	oxidoreductase activity
SAP2_RS06780	COG0667	Aldo Keto reductase
SAP2_RS06785	COG0494	nUDIX hydrolase
SAP2_RS06790	COG0735	belongs to the Fur family
SAP2_RS06795	COG4974	Belongs to the 'phage' integrase family
SAP2_RS06805	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SAP2_RS06810	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SAP2_RS06815	COG1187	pseudouridine synthase activity
SAP2_RS06820	COG0745	RESPONSE REGULATOR receiver
SAP2_RS06835	COG1141	Ferredoxin
SAP2_RS06845	COG0514	ATP-dependent DNA helicase (RecQ)
SAP2_RS06850	COG1388	LysM domain
SAP2_RS06855	COG0492	ferredoxin-NADP+ reductase activity
SAP2_RS06860	COG0252	asparaginase activity
SAP2_RS06865	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SAP2_RS06870	COG0539	negative regulation of cytoplasmic translation
SAP2_RS06875	COG1160	GTP binding
SAP2_RS06880	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SAP2_RS06895	COG2226	methyltransferase
SAP2_RS06905	COG0105	UTP biosynthetic process
SAP2_RS06910	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SAP2_RS06915	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SAP2_RS06920	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SAP2_RS06930	COG5582	Belongs to the UPF0302 family
SAP2_RS06935	COG4347	Protein of unknown function (DUF1405)
SAP2_RS06940	COG2738	Putative neutral zinc metallopeptidase
SAP2_RS06945	COG1694	Mazg nucleotide pyrophosphohydrolase
SAP2_RS06950	COG0438	transferase activity, transferring glycosyl groups
SAP2_RS06955	COG0617	tRNA 3'-terminal CCA addition
SAP2_RS06960	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SAP2_RS06960	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SAP2_RS06965	COG1199	ATP-dependent helicase activity
SAP2_RS06965	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SAP2_RS06970	COG0017	Asparaginyl-tRNA synthetase
SAP2_RS06975	COG3935	DnaD domain protein
SAP2_RS06980	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SAP2_RS06995	COG3331	DNA recombination
SAP2_RS07005	COG4474	Belongs to the UPF0398 family
SAP2_RS07020	COG0116	Belongs to the methyltransferase superfamily
SAP2_RS07025	COG2962	Rard protein
SAP2_RS07035	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
SAP2_RS07040	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SAP2_RS07045	COG0328	RNA-DNA hybrid ribonuclease activity
SAP2_RS07050	COG3545	Serine hydrolase
SAP2_RS07055	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SAP2_RS07065	COG1413	lyase activity
SAP2_RS07075	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SAP2_RS07095	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SAP2_RS07100	COG2190	(PTS) system
SAP2_RS07105	COG4479	Belongs to the UPF0346 family
SAP2_RS07110	COG0793	Belongs to the peptidase S41A family
SAP2_RS07120	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SAP2_RS07125	COG0671	phosphoesterase, PA-phosphatase related
SAP2_RS07130	COG0745	RESPONSE REGULATOR receiver
SAP2_RS07135	COG5002	protein histidine kinase activity
SAP2_RS07140	COG0567	Dehydrogenase, E1 component
SAP2_RS07145	COG0508	dehydrogenase complex catalyzes the overall conversion of
SAP2_RS07155	COG1396	sequence-specific DNA binding
SAP2_RS07165	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SAP2_RS07185	COG0714	Associated with various cellular activities
SAP2_RS07190	COG4548	von Willebrand factor, type A
SAP2_RS07195	COG1114	Component of the transport system for branched-chain amino acids
SAP2_RS07200	COG3853	Toxic anion resistance protein (TelA)
SAP2_RS07210	COG1254	Belongs to the acylphosphatase family
SAP2_RS07220	COG1278	Cold shock
SAP2_RS07235	COG1473	amidohydrolase
SAP2_RS07240	COG2171	N-acyltransferase activity
SAP2_RS07245	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SAP2_RS07250	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SAP2_RS07255	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SAP2_RS07260	COG0527	aspartate kinase activity
SAP2_RS07270	COG0488	(ABC) transporter
SAP2_RS07275	COG2996	Protein conserved in bacteria
SAP2_RS07280	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SAP2_RS07285	COG0573	inorganic phosphate transmembrane transporter activity
SAP2_RS07290	COG0581	inorganic phosphate transmembrane transporter activity
SAP2_RS07295	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SAP2_RS07300	COG0704	Plays a role in the regulation of phosphate uptake
SAP2_RS07315	COG4607	ABC-type enterochelin transport system periplasmic component
SAP2_RS07325	COG2348	transferase activity, transferring amino-acyl groups
SAP2_RS07335	COG0159	tryptophan synthase activity
SAP2_RS07340	COG0133	tryptophan synthase activity
SAP2_RS07350	COG0134	indole-3-glycerol-phosphate synthase activity
SAP2_RS07355	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SAP2_RS07360	COG0512	Glutamine amidotransferase of anthranilate synthase
SAP2_RS07365	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SAP2_RS07370	COG0287	Prephenate dehydrogenase
SAP2_RS07375	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SAP2_RS07405	COG0392	lysyltransferase activity
SAP2_RS07405	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SAP2_RS07410	COG0628	permease
SAP2_RS07420	COG3711	transcriptional antiterminator
SAP2_RS07425	COG1115	amino acid carrier protein
SAP2_RS07430	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SAP2_RS07440	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SAP2_RS07445	COG4841	protein insertion into membrane
SAP2_RS07450	COG0824	Thioesterase
SAP2_RS07455	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SAP2_RS07460	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SAP2_RS07465	COG1970	mechanosensitive ion channel activity
SAP2_RS07470	COG0419	ATPase involved in DNA repair
SAP2_RS07475	COG0420	3'-5' exonuclease activity
SAP2_RS07480	COG4846	Membrane protein involved in cytochrome C biogenesis
SAP2_RS07535	COG4224	UPF0291 protein
SAP2_RS07545	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SAP2_RS07555	COG0516	GMP reductase activity
SAP2_RS07560	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SAP2_RS07565	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SAP2_RS07570	COG0753	catalase activity
SAP2_RS07575	COG0833	amino acid
SAP2_RS07590	COG0083	homoserine kinase activity
SAP2_RS07595	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SAP2_RS07600	COG0460	homoserine dehydrogenase
SAP2_RS07605	COG0527	aspartate kinase activity
SAP2_RS07625	COG2814	Major facilitator Superfamily
SAP2_RS07695	COG0789	Transcriptional regulator
SAP2_RS07700	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SAP2_RS07705	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SAP2_RS07710	COG0386	Belongs to the glutathione peroxidase family
SAP2_RS07715	COG1923	regulation of RNA biosynthetic process
SAP2_RS07720	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SAP2_RS07730	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SAP2_RS07735	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SAP2_RS07740	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SAP2_RS07745	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
SAP2_RS07750	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SAP2_RS07755	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SAP2_RS07770	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SAP2_RS07780	COG4195	phage-related replication protein
SAP2_RS07785	COG4195	phage-related replication protein
SAP2_RS07790	COG1013	pyruvate-flavodoxin oxidoreductase activity
SAP2_RS07795	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SAP2_RS07795	COG0674	pyruvate-flavodoxin oxidoreductase activity
SAP2_RS07800	COG1692	metallophosphoesterase
SAP2_RS07810	COG1418	mRNA catabolic process
SAP2_RS07815	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SAP2_RS07820	COG1546	Belongs to the CinA family
SAP2_RS07820	COG1058	Belongs to the CinA family
SAP2_RS07840	COG0300	oxidoreductase activity
SAP2_RS07845	COG0612	Peptidase, M16
SAP2_RS07850	COG0612	Peptidase, M16
SAP2_RS07855	COG2188	Transcriptional regulator
SAP2_RS07860	COG1674	ftsk spoiiie
SAP2_RS07865	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SAP2_RS07870	COG1185	polyribonucleotide nucleotidyltransferase activity
SAP2_RS07880	COG0196	riboflavin kinase activity
SAP2_RS07885	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SAP2_RS07890	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SAP2_RS07905	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SAP2_RS07910	COG1358	cellular component organization or biogenesis
SAP2_RS07915	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SAP2_RS07920	COG0195	Participates in both transcription termination and antitermination
SAP2_RS07925	COG0779	Required for maturation of 30S ribosomal subunits
SAP2_RS07930	COG2176	DNA-directed DNA polymerase activity
SAP2_RS07935	COG0442	prolyl-tRNA aminoacylation
SAP2_RS07945	COG4589	Belongs to the CDS family
SAP2_RS07950	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SAP2_RS07955	COG0233	cytoplasmic translational termination
SAP2_RS07960	COG0528	UMP kinase activity
SAP2_RS07965	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SAP2_RS07970	COG0052	Belongs to the universal ribosomal protein uS2 family
SAP2_RS07975	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SAP2_RS07980	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
SAP2_RS07985	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SAP2_RS07990	COG4974	Belongs to the 'phage' integrase family
SAP2_RS07995	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SAP2_RS08000	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SAP2_RS08005	COG0758	DNA mediated transformation
SAP2_RS08015	COG0045	succinate-CoA ligase (ADP-forming) activity
SAP2_RS08020	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SAP2_RS08030	COG4485	Bacterial membrane protein, YfhO
SAP2_RS08045	COG0336	Belongs to the RNA methyltransferase TrmD family
SAP2_RS08050	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SAP2_RS08060	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SAP2_RS08065	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
SAP2_RS08070	COG0552	protein localization to endoplasmic reticulum
SAP2_RS08075	COG1196	nuclear chromosome segregation
SAP2_RS08080	COG0571	ribonuclease III activity
SAP2_RS08085	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SAP2_RS08090	COG1028	Short-chain dehydrogenase reductase Sdr
SAP2_RS08100	COG0416	fatty acid biosynthetic process
SAP2_RS08105	COG1349	DNA-binding transcription factor activity
SAP2_RS08120	COG1760	l-serine dehydratase
SAP2_RS08125	COG1760	l-serine dehydratase
SAP2_RS08130	COG1461	Dihydroxyacetone kinase
SAP2_RS08135	COG1302	Protein conserved in bacteria
SAP2_RS08140	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SAP2_RS08145	COG1564	THIamine pyrophosphokinase
SAP2_RS08150	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SAP2_RS08155	COG1162	GTPase activity
SAP2_RS08165	COG0631	protein serine/threonine phosphatase activity
SAP2_RS08170	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SAP2_RS08175	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SAP2_RS08175	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SAP2_RS08180	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SAP2_RS08195	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SAP2_RS08200	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SAP2_RS08205	COG1758	RNA polymerase activity
SAP2_RS08210	COG0194	GDP metabolic process
SAP2_RS08225	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SAP2_RS08245	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SAP2_RS08250	COG0505	Belongs to the CarA family
SAP2_RS08260	COG0540	Belongs to the ATCase OTCase family
SAP2_RS08265	COG2233	PERMEase
SAP2_RS08270	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SAP2_RS08275	COG0564	pseudouridine synthase activity
SAP2_RS08280	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SAP2_RS08290	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SAP2_RS08295	COG3599	regulation of cell shape
SAP2_RS08305	COG0762	integral membrane protein
SAP2_RS08310	COG1799	cell septum assembly
SAP2_RS08315	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SAP2_RS08320	COG1496	oxidoreductase activity
SAP2_RS08325	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SAP2_RS08330	COG0849	cell division
SAP2_RS08335	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SAP2_RS08340	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SAP2_RS08345	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SAP2_RS08350	COG0768	penicillin binding
SAP2_RS08355	COG4839	cell division protein FtsL
SAP2_RS08360	COG0275	rRNA processing
SAP2_RS08365	COG2001	Belongs to the MraZ family
SAP2_RS08370	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
SAP2_RS08375	COG0454	-acetyltransferase
SAP2_RS08380	COG1011	Hydrolase
SAP2_RS08385	COG1917	Cupin 2, conserved barrel domain protein
SAP2_RS08385	COG2207	Transcriptional regulator
SAP2_RS08410	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SAP2_RS08415	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SAP2_RS08420	COG1053	succinate dehydrogenase
SAP2_RS08425	COG2009	succinate dehydrogenase
SAP2_RS08430	COG0322	excinuclease ABC activity
SAP2_RS08435	COG3118	belongs to the thioredoxin family
SAP2_RS08440	COG1193	negative regulation of DNA recombination
SAP2_RS08445	COG1796	DNA polymerase
SAP2_RS08445	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SAP2_RS08455	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
SAP2_RS08460	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SAP2_RS08465	COG0072	phenylalanine-tRNA ligase activity
SAP2_RS08470	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SAP2_RS08475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SAP2_RS08485	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SAP2_RS08500	COG1323	Belongs to the UPF0348 family
SAP2_RS08505	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SAP2_RS08510	COG0742	ribosomal rna small subunit methyltransferase
SAP2_RS08520	COG4471	UPF0298 protein
SAP2_RS08530	COG3679	Belongs to the UPF0342 family
SAP2_RS08545	COG0109	protoheme IX farnesyltransferase activity
SAP2_RS08550	COG1612	heme a metabolic process
SAP2_RS08565	COG0772	Belongs to the SEDS family
SAP2_RS08570	COG4838	Belongs to the UPF0358 family
SAP2_RS08575	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SAP2_RS08580	COG4896	Protein conserved in bacteria
SAP2_RS08585	COG1217	gtp-binding protein TYPA
SAP2_RS08595	COG0483	inositol monophosphate 1-phosphatase activity
SAP2_RS08600	COG4493	Belongs to the UPF0637 family
SAP2_RS08620	COG1177	transmembrane transport
SAP2_RS08625	COG1176	ABC-type spermidine putrescine transport system, permease component I
SAP2_RS08635	COG4476	Belongs to the UPF0223 family
SAP2_RS08675	COG5503	Protein of unknown function (DUF1447)
SAP2_RS08680	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SAP2_RS08685	COG0569	domain protein
SAP2_RS08690	COG1294	oxidase, subunit
SAP2_RS08695	COG1271	oxidase subunit
SAP2_RS08710	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SAP2_RS08720	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SAP2_RS08740	COG1122	ATPase activity
SAP2_RS08745	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SAP2_RS08755	COG0138	bifunctional purine biosynthesis protein purh
SAP2_RS08765	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SAP2_RS08770	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SAP2_RS08775	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SAP2_RS08780	COG0047	phosphoribosylformylglycinamidine synthase activity
SAP2_RS08785	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SAP2_RS08790	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SAP2_RS08795	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SAP2_RS08800	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SAP2_RS08805	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SAP2_RS08820	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SAP2_RS08830	COG1845	cytochrome c oxidase, subunit III
SAP2_RS08835	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
SAP2_RS08845	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SAP2_RS08850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SAP2_RS08855	COG1316	TRANSCRIPTIONal
SAP2_RS08885	COG3594	Acyltransferase
SAP2_RS08890	COG0436	Aminotransferase
SAP2_RS08895	COG1846	Transcriptional regulator
SAP2_RS08900	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SAP2_RS08905	COG0596	Alpha beta hydrolase
SAP2_RS08910	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SAP2_RS08915	COG1169	isochorismate synthase
SAP2_RS08920	COG1575	Belongs to the MenA family. Type 1 subfamily
SAP2_RS08930	COG2314	TM2 domain
SAP2_RS08935	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SAP2_RS08940	COG0438	transferase activity, transferring glycosyl groups
SAP2_RS08960	COG4903	ComK protein
SAP2_RS08975	COG4873	Protein conserved in bacteria
SAP2_RS09000	COG0737	Belongs to the 5'-nucleotidase family
SAP2_RS09005	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SAP2_RS09010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SAP2_RS09015	COG0861	Integral membrane protein TerC family
SAP2_RS09020	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SAP2_RS09035	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SAP2_RS09040	COG2814	Major facilitator Superfamily
SAP2_RS09045	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
SAP2_RS09050	COG2382	esterase
SAP2_RS09055	COG1115	amino acid carrier protein
SAP2_RS09060	COG0628	permease
SAP2_RS09070	COG0475	glutathione-regulated potassium exporter activity
SAP2_RS09070	COG0569	domain protein
SAP2_RS09075	COG2239	Acts as a magnesium transporter
SAP2_RS09080	COG0564	pseudouridine synthase activity
SAP2_RS09085	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SAP2_RS09090	COG2357	RelA SpoT domain protein
SAP2_RS09105	COG2346	COG2346, Truncated hemoglobins
SAP2_RS09110	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SAP2_RS09115	COG1164	Oligoendopeptidase f
SAP2_RS09125	COG4862	establishment of competence for transformation
SAP2_RS09130	COG1393	Belongs to the ArsC family
SAP2_RS09135	COG0180	Tryptophanyl-tRNA synthetase
SAP2_RS09140	COG4166	transmembrane transport
SAP2_RS09145	COG4608	Belongs to the ABC transporter superfamily
SAP2_RS09150	COG0444	Belongs to the ABC transporter superfamily
SAP2_RS09155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SAP2_RS09160	COG0601	transmembrane transport
SAP2_RS09175	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SAP2_RS09185	COG0542	response to heat
SAP2_RS09195	COG1522	sequence-specific DNA binding
SAP2_RS09205	COG0561	phosphatase activity
SAP2_RS09210	COG0446	pyridine nucleotide-disulphide oxidoreductase
SAP2_RS09220	COG0179	Fumarylacetoacetate (FAA) hydrolase
SAP2_RS09225	COG2311	Membrane
SAP2_RS09230	COG1074	ATP-dependent DNA helicase activity
SAP2_RS09235	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
SAP2_RS09250	COG0398	Pfam SNARE associated Golgi protein
SAP2_RS09255	COG0166	Belongs to the GPI family
SAP2_RS09260	COG0137	argininosuccinate synthase activity
SAP2_RS09265	COG0165	Argininosuccinate lyase
SAP2_RS09270	COG0584	glycerophosphoryl diester phosphodiesterase
SAP2_RS09285	COG1902	pentaerythritol trinitrate reductase activity
SAP2_RS09290	COG1098	S1 RNA binding domain
SAP2_RS09295	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SAP2_RS09305	COG2111	Na H antiporter
SAP2_RS09305	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SAP2_RS09310	COG2111	Na H antiporter
SAP2_RS09315	COG1006	Multisubunit Na H antiporter MnhC subunit
SAP2_RS09320	COG0651	ATP synthesis coupled electron transport
SAP2_RS09325	COG1863	multisubunit Na H antiporter MnhE subunit
SAP2_RS09330	COG2212	antiporter activity
SAP2_RS09335	COG1320	monovalent cation:proton antiporter activity
SAP2_RS09345	COG2050	protein possibly involved in aromatic compounds catabolism
SAP2_RS09350	COG2056	Na+-H+ antiporter family
SAP2_RS09355	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SAP2_RS09360	COG1252	NADH dehydrogenase
SAP2_RS09365	COG0316	Belongs to the HesB IscA family
SAP2_RS09370	COG4844	belongs to the
SAP2_RS09375	COG1252	NADH dehydrogenase
SAP2_RS09380	COG4837	Protein of unknown function (DUF1462)
SAP2_RS09385	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SAP2_RS09390	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SAP2_RS09395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SAP2_RS09400	COG1696	Membrane protein involved in D-alanine export
SAP2_RS09405	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SAP2_RS09420	COG0647	UMP catabolic process
SAP2_RS09425	COG2445	Protein of unknown function DUF86
SAP2_RS09435	COG4470	Protein conserved in bacteria
SAP2_RS09440	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SAP2_RS09445	COG0737	Belongs to the 5'-nucleotidase family
SAP2_RS09450	COG1801	Protein of unknown function DUF72
SAP2_RS09455	COG2070	2-Nitropropane dioxygenase
SAP2_RS09460	COG1253	flavin adenine dinucleotide binding
SAP2_RS09465	COG0719	Fe-S assembly protein
SAP2_RS09470	COG0822	iron-sulfur transferase activity
SAP2_RS09475	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SAP2_RS09480	COG0719	Fe-S assembly protein
SAP2_RS09485	COG0396	ATPase activity
SAP2_RS09495	COG1253	flavin adenine dinucleotide binding
SAP2_RS09500	COG1464	Belongs to the NlpA lipoprotein family
SAP2_RS09505	COG2011	ABC-type metal ion transport system permease component
SAP2_RS09510	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SAP2_RS09520	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
SAP2_RS09525	COG0509	glycine decarboxylation via glycine cleavage system
SAP2_RS09530	COG1393	Belongs to the ArsC family
SAP2_RS09535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SAP2_RS09540	COG0778	Nitroreductase
SAP2_RS09545	COG0710	3-dehydroquinate dehydratase activity
SAP2_RS09550	COG1764	response to oxidative stress
SAP2_RS09565	COG2851	Citrate transporter
SAP2_RS09585	COG2314	TM2 domain
SAP2_RS09615	COG2153	protein acetylation
SAP2_RS09630	COG0300	oxidoreductase activity
SAP2_RS09650	COG0456	acetyltransferase
SAP2_RS09685	COG0519	Catalyzes the synthesis of GMP from XMP
SAP2_RS09750	COG3177	Filamentation induced by cAMP protein fic
SAP2_RS09770	COG1611	Belongs to the LOG family
SAP2_RS09890	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SAP2_RS09895	COG0557	exoribonuclease II activity
SAP2_RS09900	COG1647	Serine aminopeptidase, S33
SAP2_RS09905	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SAP2_RS09915	COG0148	phosphopyruvate hydratase activity
SAP2_RS09920	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SAP2_RS09925	COG0149	triose-phosphate isomerase activity
SAP2_RS09930	COG0126	phosphoglycerate kinase activity
SAP2_RS09960	COG1090	epimerase
SAP2_RS09965	COG0740	serine-type endopeptidase activity
SAP2_RS09980	COG1481	regulation of sporulation
SAP2_RS09985	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SAP2_RS09990	COG1660	Displays ATPase and GTPase activities
SAP2_RS09995	COG0492	ferredoxin-NADP+ reductase activity
SAP2_RS10005	COG0110	maltose O-acetyltransferase activity
SAP2_RS10010	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SAP2_RS10015	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SAP2_RS10020	COG1063	alcohol dehydrogenase
SAP2_RS10025	COG1063	alcohol dehydrogenase
SAP2_RS10030	COG3775	system Galactitol-specific IIC component
SAP2_RS10035	COG3414	Phosphotransferase system galactitol-specific IIB component
SAP2_RS10050	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SAP2_RS10055	COG0556	nucleotide-excision repair
SAP2_RS10075	COG0653	protein targeting
SAP2_RS10080	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SAP2_RS10085	COG1040	competence protein
SAP2_RS10090	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SAP2_RS10100	COG1739	Uncharacterized protein family UPF0029
SAP2_RS10105	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SAP2_RS10110	COG2199	diguanylate cyclase activity
SAP2_RS10125	COG2195	Cleaves the N-terminal amino acid of tripeptides
SAP2_RS10130	COG1929	Belongs to the glycerate kinase type-1 family
SAP2_RS10150	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SAP2_RS10160	COG4607	ABC-type enterochelin transport system periplasmic component
SAP2_RS10165	COG4604	ABC transporter, ATP-binding protein
SAP2_RS10170	COG4605	iron ion homeostasis
SAP2_RS10175	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SAP2_RS10180	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SAP2_RS10185	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SAP2_RS10190	COG1780	Probably involved in ribonucleotide reductase function
SAP2_RS10195	COG2962	Rard protein
SAP2_RS10200	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SAP2_RS10205	COG3104	oligopeptide transport
SAP2_RS10210	COG3104	oligopeptide transport
SAP2_RS10215	COG1597	lipid kinase activity
SAP2_RS10225	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SAP2_RS10230	COG1174	glycine betaine transport
SAP2_RS10240	COG0514	ATP-dependent DNA helicase (RecQ)
SAP2_RS10245	COG0488	(ABC) transporter
SAP2_RS10255	COG1368	sulfuric ester hydrolase activity
SAP2_RS10265	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SAP2_RS10285	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SAP2_RS10285	COG0512	Glutamine amidotransferase of anthranilate synthase
SAP2_RS10290	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SAP2_RS10295	COG0720	synthase
SAP2_RS10300	COG0602	queuosine metabolic process
SAP2_RS10315	COG0463	Glycosyl transferase, family 2
SAP2_RS10320	COG0656	L-ascorbic acid biosynthetic process
SAP2_RS10325	COG1253	flavin adenine dinucleotide binding
SAP2_RS10330	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SAP2_RS10335	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SAP2_RS10335	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SAP2_RS10335	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SAP2_RS10340	COG1105	Belongs to the carbohydrate kinase PfkB family
SAP2_RS10345	COG1349	DNA-binding transcription factor activity
SAP2_RS10350	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SAP2_RS10380	COG0039	L-malate dehydrogenase activity
SAP2_RS10385	COG0586	Pfam SNARE associated Golgi protein
SAP2_RS10395	COG4989	oxidoreductase activity
SAP2_RS10400	COG0523	cobalamin synthesis protein
SAP2_RS10410	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
SAP2_RS10415	COG4988	ABC transporter
SAP2_RS10420	COG1968	undecaprenyl-diphosphatase activity
SAP2_RS10430	COG1671	Belongs to the UPF0178 family
SAP2_RS10435	COG1611	Belongs to the LOG family
SAP2_RS10465	COG2814	Major facilitator Superfamily
SAP2_RS10470	COG2839	Protein conserved in bacteria
SAP2_RS10475	COG2814	Major facilitator Superfamily
SAP2_RS10480	COG0583	DNA-binding transcription factor activity
SAP2_RS10490	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SAP2_RS10500	COG0217	transcriptional regulatory protein
SAP2_RS10510	COG3942	CHAP domain
SAP2_RS10510	COG1388	LysM domain
SAP2_RS10515	COG0306	phosphate transporter
SAP2_RS10520	COG1392	Phosphate transport regulator
SAP2_RS10525	COG2205	protein histidine kinase activity
SAP2_RS10530	COG0745	RESPONSE REGULATOR receiver
SAP2_RS10535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SAP2_RS10545	COG0657	acetylesterase activity
SAP2_RS10550	COG3949	Membrane
SAP2_RS10560	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
SAP2_RS10565	COG1461	Dihydroxyacetone kinase
SAP2_RS10570	COG2376	Dihydroxyacetone kinase
SAP2_RS10575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SAP2_RS10580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SAP2_RS10585	COG1120	ATPase activity
SAP2_RS10590	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SAP2_RS10595	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SAP2_RS10600	COG1132	(ABC) transporter
SAP2_RS10610	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SAP2_RS10620	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SAP2_RS10625	COG1682	transport, permease protein
SAP2_RS10630	COG1134	teichoic acid transport
SAP2_RS10635	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
SAP2_RS10645	COG1321	iron dependent repressor
SAP2_RS10650	COG1121	(ABC) transporter
SAP2_RS10655	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SAP2_RS10660	COG0803	Belongs to the bacterial solute-binding protein 9 family
SAP2_RS10670	COG1320	monovalent cation:proton antiporter activity
SAP2_RS10675	COG2212	antiporter activity
SAP2_RS10680	COG1863	multisubunit Na H antiporter MnhE subunit
SAP2_RS10685	COG0651	ATP synthesis coupled electron transport
SAP2_RS10690	COG1006	Multisubunit Na H antiporter MnhC subunit
SAP2_RS10695	COG2111	Na H antiporter
SAP2_RS10700	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SAP2_RS10700	COG2111	Na H antiporter
SAP2_RS10705	COG4974	Belongs to the 'phage' integrase family
SAP2_RS10760	COG4139	cobalamin transport
SAP2_RS10765	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SAP2_RS10775	COG0018	arginyl-trna synthetase
SAP2_RS10790	COG1078	dGTPase activity
SAP2_RS10800	COG0655	NAD(P)H dehydrogenase (quinone) activity
SAP2_RS10805	COG0667	Aldo Keto reductase
SAP2_RS10810	COG4844	belongs to the
SAP2_RS10820	COG0673	inositol 2-dehydrogenase activity
SAP2_RS10830	COG0673	inositol 2-dehydrogenase activity
SAP2_RS10835	COG1737	Transcriptional regulator
SAP2_RS10855	COG0095	Lipoate-protein ligase
SAP2_RS10860	COG0280	phosphate acetyltransferase
SAP2_RS10865	COG3253	May function as heme-dependent peroxidase
SAP2_RS10885	COG2363	Small membrane protein
SAP2_RS10895	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SAP2_RS10900	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
SAP2_RS10910	COG0477	Major facilitator Superfamily
SAP2_RS10925	COG0183	Belongs to the thiolase family
SAP2_RS10930	COG0318	PFAM AMP-dependent synthetase and ligase
SAP2_RS10940	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
SAP2_RS10945	COG0363	glucosamine-6-phosphate deaminase activity
SAP2_RS10950	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SAP2_RS10955	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SAP2_RS10960	COG1469	GTP cyclohydrolase I activity
SAP2_RS10970	COG0431	NADPH-dependent FMN reductase
SAP2_RS10975	COG0561	phosphatase activity
SAP2_RS10985	COG1428	Deoxynucleoside kinase
SAP2_RS10990	COG1428	Deoxynucleoside kinase
SAP2_RS11000	COG0546	phosphoglycolate phosphatase activity
SAP2_RS11010	COG0436	Aminotransferase
SAP2_RS11045	COG0384	phenazine biosynthesis protein PhzF
SAP2_RS11050	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SAP2_RS11055	COG3181	Tripartite tricarboxylate transporter family receptor
SAP2_RS11070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SAP2_RS11080	COG2814	Major facilitator Superfamily
SAP2_RS11090	COG0583	DNA-binding transcription factor activity
SAP2_RS11095	COG2814	Major facilitator Superfamily
SAP2_RS11105	COG1113	amino acid transport
SAP2_RS11110	COG0010	Belongs to the arginase family
SAP2_RS11115	COG1914	H( )-stimulated, divalent metal cation uptake system
SAP2_RS11120	COG1069	ribulokinase activity
SAP2_RS11130	COG1349	DNA-binding transcription factor activity
SAP2_RS11135	COG1501	Belongs to the glycosyl hydrolase 31 family
SAP2_RS11140	COG0656	L-ascorbic acid biosynthetic process
SAP2_RS11145	COG2814	Major facilitator Superfamily
SAP2_RS11150	COG1733	regulation of RNA biosynthetic process
SAP2_RS11165	COG1028	Short-chain dehydrogenase reductase Sdr
SAP2_RS11170	COG1312	Catalyzes the dehydration of D-mannonate
SAP2_RS11175	COG1904	glucuronate isomerase
SAP2_RS11200	COG0800	Aldolase
SAP2_RS11205	COG1609	Transcriptional regulator
SAP2_RS11220	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SAP2_RS11225	COG1113	amino acid transport
SAP2_RS11235	COG0531	amino acid
SAP2_RS11240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SAP2_RS11255	COG1028	Short-chain dehydrogenase reductase Sdr
SAP2_RS11260	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SAP2_RS11265	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SAP2_RS11270	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SAP2_RS11275	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
SAP2_RS11285	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SAP2_RS11290	COG0297	glycogen (starch) synthase activity
SAP2_RS11315	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SAP2_RS11325	COG1086	Polysaccharide biosynthesis protein
SAP2_RS11370	COG1473	amidohydrolase
SAP2_RS11375	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SAP2_RS11380	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SAP2_RS11385	COG0049	tRNA binding
SAP2_RS11390	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SAP2_RS11400	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SAP2_RS11405	COG0085	RNA polymerase activity
SAP2_RS11410	COG2813	Specifically methylates the guanine in position
SAP2_RS11420	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SAP2_RS11430	COG0081	regulation of translation
SAP2_RS11435	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SAP2_RS11440	COG0250	Participates in transcription elongation, termination and antitermination
SAP2_RS11450	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SAP2_RS11465	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SAP2_RS11470	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SAP2_RS11475	COG0215	cysteine-tRNA ligase activity
SAP2_RS11480	COG1045	serine acetyltransferase
SAP2_RS11485	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SAP2_RS11490	COG4956	integral membrane protein (PIN domain superfamily)
SAP2_RS11495	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SAP2_RS11500	COG0542	response to heat
SAP2_RS11505	COG3869	Catalyzes the specific phosphorylation of arginine residues in
SAP2_RS11510	COG3880	PFAM UvrB UvrC protein
SAP2_RS11515	COG4463	regulation of RNA biosynthetic process
SAP2_RS11520	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SAP2_RS11540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SAP2_RS11625	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SAP2_RS11630	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SAP2_RS11645	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SAP2_RS11650	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SAP2_RS11655	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SAP2_RS11670	COG1098	S1 RNA binding domain
SAP2_RS11680	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SAP2_RS11685	COG3956	TIGRFAM MazG family protein
SAP2_RS11690	COG2244	polysaccharide biosynthetic process
SAP2_RS11695	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SAP2_RS11700	COG0193	aminoacyl-tRNA hydrolase activity
SAP2_RS11710	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SAP2_RS11715	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SAP2_RS11720	COG2088	sporulation resulting in formation of a cellular spore
SAP2_RS11725	COG0251	oxidation-reduction process
SAP2_RS11730	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SAP2_RS11735	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SAP2_RS11740	COG4466	Protein conserved in bacteria
SAP2_RS11745	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SAP2_RS11750	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
SAP2_RS11755	COG0084	hydrolase, TatD family'
SAP2_RS11760	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SAP2_RS11760	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SAP2_RS11765	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SAP2_RS11770	COG2827	Endonuclease containing a URI domain
SAP2_RS11775	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SAP2_RS11780	COG4467	Involved in initiation control of chromosome replication
SAP2_RS11785	COG1774	PSP1 C-terminal conserved region
SAP2_RS11790	COG0470	DNA polymerase III
SAP2_RS11795	COG3870	Protein conserved in bacteria
SAP2_RS11800	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SAP2_RS11805	COG1982	Orn Lys Arg decarboxylase major
SAP2_RS11840	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SAP2_RS11845	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SAP2_RS11850	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SAP2_RS11865	COG2188	Transcriptional regulator
SAP2_RS11870	COG0366	Alpha amylase catalytic
SAP2_RS11875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SAP2_RS11875	COG1263	PTS System
SAP2_RS11885	COG0493	'glutamate synthase
SAP2_RS11890	COG0070	glutamate synthase
SAP2_RS11890	COG0069	glutamate synthase activity
SAP2_RS11890	COG0067	glutamate synthase
SAP2_RS11895	COG0583	DNA-binding transcription factor activity
SAP2_RS11910	COG0004	ammonium transporteR
SAP2_RS11925	COG3942	CHAP domain
SAP2_RS11925	COG1388	LysM domain
SAP2_RS11940	COG0733	neurotransmitter:sodium symporter activity
SAP2_RS11945	COG1114	Component of the transport system for branched-chain amino acids
SAP2_RS11950	COG5646	InterPro IPR014922
SAP2_RS11965	COG4195	phage-related replication protein
SAP2_RS11970	COG2814	Major facilitator Superfamily
SAP2_RS11980	COG0523	cobalamin synthesis protein
SAP2_RS11990	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SAP2_RS11990	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SAP2_RS11995	COG4297	protein containing double-stranded beta helix domain
SAP2_RS12000	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SAP2_RS12030	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SAP2_RS12030	COG0519	Catalyzes the synthesis of GMP from XMP
SAP2_RS12035	COG0516	GMP reductase activity
SAP2_RS12035	COG0517	IMP dehydrogenase activity
SAP2_RS12040	COG2233	PERMEase
SAP2_RS12045	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SAP2_RS12065	COG1823	symporter activity
SAP2_RS12075	COG0778	Nitroreductase
SAP2_RS12085	COG0450	alkyl hydroperoxide reductase
SAP2_RS12115	COG0406	alpha-ribazole phosphatase activity
SAP2_RS12125	COG1280	lysine exporter protein (LysE YggA)
SAP2_RS12130	COG2076	Multidrug Resistance protein
SAP2_RS12135	COG2076	Multidrug Resistance protein
SAP2_RS12145	COG1764	response to oxidative stress
SAP2_RS12150	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SAP2_RS12155	COG1940	carbohydrate kinase activity
SAP2_RS12155	COG1846	Transcriptional regulator
SAP2_RS12165	COG1070	Carbohydrate kinase
SAP2_RS12170	COG2814	Major facilitator Superfamily
SAP2_RS12170	COG0477	Major facilitator Superfamily
SAP2_RS12175	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SAP2_RS12180	COG0157	Belongs to the NadC ModD family
SAP2_RS12185	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SAP2_RS12195	COG1827	regulation of RNA biosynthetic process
SAP2_RS12200	COG1511	domain protein
SAP2_RS12210	COG0753	catalase activity
SAP2_RS12215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SAP2_RS12220	COG1279	arginine transmembrane transporter activity
SAP2_RS12235	COG3682	Transcriptional regulator
SAP2_RS12250	COG2030	dehydratase
SAP2_RS12260	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SAP2_RS12275	COG0346	lactoylglutathione lyase activity
SAP2_RS12290	COG0596	Alpha beta hydrolase
SAP2_RS12295	COG4195	phage-related replication protein
SAP2_RS12310	COG1611	Belongs to the LOG family
SAP2_RS12360	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SAP2_RS12385	COG0360	Binds together with S18 to 16S ribosomal RNA
SAP2_RS12395	COG0012	GTP binding
SAP2_RS12400	COG4481	Protein conserved in bacteria
SAP2_RS12405	COG0668	transmembrane transport
SAP2_RS12415	COG2851	Citrate transporter
SAP2_RS12425	COG2211	Major facilitator Superfamily
SAP2_RS12430	COG1486	melibiose metabolic process
SAP2_RS12440	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SAP2_RS12440	COG1017	nitric oxide dioxygenase activity
SAP2_RS12450	COG1475	DNA binding
SAP2_RS12460	COG0626	cystathionine gamma-synthase activity
SAP2_RS12465	COG0626	cystathionine gamma-synthase activity
SAP2_RS12470	COG0646	methionine synthase
SAP2_RS12470	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SAP2_RS12475	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SAP2_RS12490	COG1309	transcriptional regulator
SAP2_RS12495	COG2076	Multidrug Resistance protein
SAP2_RS12500	COG2076	Multidrug Resistance protein
SAP2_RS12515	COG0789	Transcriptional regulator
SAP2_RS12525	COG1388	LysM domain
SAP2_RS12575	COG1346	cytolysis
SAP2_RS12580	COG1380	Effector of murein hydrolase LrgA
SAP2_RS12600	COG0789	Transcriptional regulator
SAP2_RS12610	COG0583	DNA-binding transcription factor activity
SAP2_RS12615	COG1607	acyl-coa hydrolase
SAP2_RS12645	COG1475	DNA binding
SAP2_RS12650	COG0357	Ribosomal RNA small subunit methyltransferase G
SAP2_RS12655	COG0445	tRNA wobble uridine modification
SAP2_RS12660	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SAP2_RS12665	COG0594	ribonuclease P activity
SAP2_RS12705	COG2217	Heavy metal translocating P-type atpase
SAP2_RS12710	COG1937	Protein conserved in bacteria
SAP2_RS12720	COG1230	cation diffusion facilitator family transporter
SAP2_RS12765	COG1309	transcriptional regulator
SAP2_RS12770	COG4335	DNA alkylation repair
SAP2_RS12785	COG2855	membrane
SAP2_RS12790	COG0583	DNA-binding transcription factor activity