locus-tag	class	description
C248_RS00015	COG2501	S4 domain
C248_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C248_RS00060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C248_RS00070	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
C248_RS00080	COG0305	Participates in initiation and elongation during chromosome replication
C248_RS00110	COG4863	YycH protein
C248_RS00120	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C248_RS00125	COG0737	Belongs to the 5'-nucleotidase family
C248_RS00135	COG1397	ADP-ribosylglycohydrolase
C248_RS00145	COG1105	Belongs to the carbohydrate kinase PfkB family
C248_RS00160	COG0584	glycerophosphoryl diester phosphodiesterase
C248_RS00165	COG2030	dehydratase
C248_RS00215	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C248_RS00250	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
C248_RS00255	COG1353	crispr-associated protein
C248_RS00260	COG1421	Csm2 Type III-A
C248_RS00265	COG1337	RAMP superfamily
C248_RS00270	COG1567	CRISPR-associated RAMP protein, Csm4 family
C248_RS00275	COG1332	CRISPR-associated RAMP protein, Csm5 family
C248_RS00340	COG2814	Major facilitator Superfamily
C248_RS00360	COG0456	acetyltransferase
C248_RS00385	COG0655	NAD(P)H dehydrogenase (quinone) activity
C248_RS00400	COG1073	alpha beta
C248_RS00410	COG2226	methyltransferase
C248_RS00420	COG0823	Involved in the tonB-independent uptake of proteins
C248_RS00435	COG1473	amidohydrolase
C248_RS00445	COG1283	sodium-dependent phosphate transmembrane transporter activity
C248_RS00450	COG4716	Myosin-crossreactive antigen
C248_RS00460	COG1620	l-lactate permease
C248_RS00475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C248_RS00480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C248_RS00485	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C248_RS00495	COG2423	ornithine cyclodeaminase activity
C248_RS00500	COG4264	IucA IucC family
C248_RS00505	COG2814	Major facilitator Superfamily
C248_RS00510	COG4264	IucA IucC family
C248_RS00515	COG4264	IucA IucC family
C248_RS00525	COG0019	diaminopimelate decarboxylase activity
C248_RS00530	COG1475	DNA binding
C248_RS00560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C248_RS00565	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C248_RS00570	COG0438	transferase activity, transferring glycosyl groups
C248_RS00605	COG0813	purine-nucleoside phosphorylase activity
C248_RS00610	COG2814	Major facilitator Superfamily
C248_RS00630	COG3639	organic phosphonate transmembrane transporter activity
C248_RS00650	COG0737	Belongs to the 5'-nucleotidase family
C248_RS00665	COG1012	belongs to the aldehyde dehydrogenase family
C248_RS00665	COG1454	alcohol dehydrogenase
C248_RS00690	COG1086	Polysaccharide biosynthesis protein
C248_RS00700	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C248_RS00730	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C248_RS00740	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C248_RS00745	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C248_RS00755	COG2832	Protein of unknown function (DUF454)
C248_RS00790	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C248_RS00795	COG1960	acyl-CoA dehydrogenase activity
C248_RS00800	COG5609	conserved protein (DUF2294)
C248_RS00855	COG1309	transcriptional regulator
C248_RS00860	COG1114	Component of the transport system for branched-chain amino acids
C248_RS00865	COG1335	isochorismatase
C248_RS00870	COG3961	Belongs to the TPP enzyme family
C248_RS00895	COG1737	Transcriptional regulator
C248_RS00920	COG0601	transmembrane transport
C248_RS00925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C248_RS00935	COG0405	Gamma-glutamyltransferase
C248_RS00955	COG3842	ATPase activity
C248_RS00965	COG1175	transmembrane transport
C248_RS00970	COG3833	ABC-type maltose transport systems, permease component
C248_RS00975	COG0673	inositol 2-dehydrogenase activity
C248_RS00980	COG0673	inositol 2-dehydrogenase activity
C248_RS00990	COG1755	Isoprenylcysteine carboxyl methyltransferase
C248_RS01050	COG0183	Belongs to the thiolase family
C248_RS01060	COG1960	acyl-CoA dehydrogenase activity
C248_RS01065	COG0318	PFAM AMP-dependent synthetase and ligase
C248_RS01085	COG0747	negative chemotaxis
C248_RS01090	COG3189	MarR family transcriptional regulator
C248_RS01120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C248_RS01120	COG1263	PTS System
C248_RS01120	COG2190	(PTS) system
C248_RS01125	COG1957	nucleoside hydrolase
C248_RS01145	COG3414	Phosphotransferase system galactitol-specific IIB component
C248_RS01150	COG3775	system Galactitol-specific IIC component
C248_RS01155	COG1063	alcohol dehydrogenase
C248_RS01165	COG1063	alcohol dehydrogenase
C248_RS01175	COG1063	alcohol dehydrogenase
C248_RS01180	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C248_RS01190	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C248_RS01200	COG1063	alcohol dehydrogenase
C248_RS01205	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C248_RS01245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C248_RS01250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C248_RS01250	COG2190	(PTS) system
C248_RS01250	COG1263	PTS System
C248_RS01255	COG2723	6-phospho-beta-galactosidase activity
C248_RS01265	COG2226	methyltransferase
C248_RS01320	COG1131	(ABC) transporter
C248_RS01340	COG1388	LysM domain
C248_RS01340	COG3942	CHAP domain
C248_RS01450	COG1114	Component of the transport system for branched-chain amino acids
C248_RS01455	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
C248_RS01465	COG0577	efflux transmembrane transporter activity
C248_RS01490	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C248_RS01495	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C248_RS01520	COG3314	Sporulation integral membrane protein YlbJ
C248_RS01530	COG0582	viral genome integration into host DNA
C248_RS01565	COG3645	SOS response
C248_RS01565	COG3646	Phage regulatory protein
C248_RS01795	COG5280	Phage tail tape measure protein TP901
C248_RS01795	COG3953	SLT domain
C248_RS01845	COG1388	LysM domain
C248_RS01845	COG0860	N-Acetylmuramoyl-L-alanine amidase
C248_RS01870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C248_RS01900	COG3037	sugar-specific permease SgaT UlaA
C248_RS01910	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C248_RS01915	COG3711	transcriptional antiterminator
C248_RS01935	COG2271	Major facilitator Superfamily
C248_RS01940	COG0346	lactoylglutathione lyase activity
C248_RS01945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C248_RS01950	COG0431	NADPH-dependent FMN reductase
C248_RS01965	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C248_RS01970	COG2822	iron ion transport
C248_RS01980	COG0672	)-iron permease
C248_RS01990	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C248_RS02000	COG1476	TRANSCRIPTIONal
C248_RS02010	COG1131	(ABC) transporter
C248_RS02045	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C248_RS02045	COG0646	methionine synthase
C248_RS02050	COG0626	cystathionine gamma-synthase activity
C248_RS02055	COG0626	cystathionine gamma-synthase activity
C248_RS02060	COG1475	DNA binding
C248_RS02065	COG0668	transmembrane transport
C248_RS02070	COG4481	Protein conserved in bacteria
C248_RS02075	COG0012	GTP binding
C248_RS02170	COG1823	symporter activity
C248_RS02200	COG2233	PERMEase
C248_RS02215	COG0582	viral genome integration into host DNA
C248_RS02270	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C248_RS02305	COG3759	membrane
C248_RS02445	COG0523	cobalamin synthesis protein
C248_RS02455	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C248_RS02465	COG5609	conserved protein (DUF2294)
C248_RS02480	COG1647	Serine aminopeptidase, S33
C248_RS02485	COG0733	neurotransmitter:sodium symporter activity
C248_RS02490	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C248_RS02495	COG0626	cystathionine gamma-synthase activity
C248_RS02505	COG2011	ABC-type metal ion transport system permease component
C248_RS02510	COG1464	Belongs to the NlpA lipoprotein family
C248_RS02545	COG0583	DNA-binding transcription factor activity
C248_RS02550	COG0067	glutamate synthase
C248_RS02550	COG0070	glutamate synthase
C248_RS02550	COG0069	glutamate synthase activity
C248_RS02555	COG0493	'glutamate synthase
C248_RS02565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C248_RS02565	COG1263	PTS System
C248_RS02570	COG0366	Alpha amylase catalytic
C248_RS02575	COG2188	Transcriptional regulator
C248_RS02590	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C248_RS02625	COG1982	Orn Lys Arg decarboxylase major
C248_RS02635	COG3870	Protein conserved in bacteria
C248_RS02645	COG0470	DNA polymerase III
C248_RS02650	COG1774	PSP1 C-terminal conserved region
C248_RS02660	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C248_RS02670	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C248_RS02685	COG0084	hydrolase, TatD family'
C248_RS02690	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C248_RS02700	COG4466	Protein conserved in bacteria
C248_RS02710	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C248_RS02715	COG0251	oxidation-reduction process
C248_RS02760	COG2244	polysaccharide biosynthetic process
C248_RS02765	COG3956	TIGRFAM MazG family protein
C248_RS02770	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C248_RS02780	COG1098	S1 RNA binding domain
C248_RS02795	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C248_RS02820	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C248_RS02905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C248_RS02920	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C248_RS02930	COG3880	PFAM UvrB UvrC protein
C248_RS02950	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C248_RS02955	COG4956	integral membrane protein (PIN domain superfamily)
C248_RS02975	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
C248_RS03025	COG2813	Specifically methylates the guanine in position
C248_RS03065	COG1473	amidohydrolase
C248_RS03095	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C248_RS03100	COG1428	Deoxynucleoside kinase
C248_RS03105	COG1428	Deoxynucleoside kinase
C248_RS03115	COG0561	phosphatase activity
C248_RS03155	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C248_RS03260	COG0095	Lipoate-protein ligase
C248_RS03265	COG0083	homoserine kinase activity
C248_RS03285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C248_RS03355	COG0667	Aldo Keto reductase
C248_RS03360	COG0655	NAD(P)H dehydrogenase (quinone) activity
C248_RS03370	COG1078	dGTPase activity
C248_RS03405	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C248_RS03410	COG4139	cobalamin transport
C248_RS03505	COG0803	Belongs to the bacterial solute-binding protein 9 family
C248_RS03510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C248_RS03515	COG1121	(ABC) transporter
C248_RS03520	COG1321	iron dependent repressor
C248_RS03530	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
C248_RS03540	COG1682	transport, permease protein
C248_RS03545	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C248_RS03555	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C248_RS03560	COG1686	Belongs to the peptidase S11 family
C248_RS03565	COG1132	(ABC) transporter
C248_RS03570	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C248_RS03580	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C248_RS03585	COG1120	ATPase activity
C248_RS03590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C248_RS03595	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C248_RS03600	COG2376	Dihydroxyacetone kinase
C248_RS03620	COG3949	Membrane
C248_RS03645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C248_RS03660	COG1136	(ABC) transporter
C248_RS03665	COG0577	efflux transmembrane transporter activity
C248_RS03670	COG1392	Phosphate transport regulator
C248_RS03675	COG0306	phosphate transporter
C248_RS03680	COG1388	LysM domain
C248_RS03680	COG3942	CHAP domain
C248_RS03690	COG4977	sequence-specific DNA binding
C248_RS03690	COG1917	Cupin 2, conserved barrel domain protein
C248_RS03720	COG0583	DNA-binding transcription factor activity
C248_RS03730	COG2814	Major facilitator Superfamily
C248_RS03735	COG2839	Protein conserved in bacteria
C248_RS03765	COG1611	Belongs to the LOG family
C248_RS03785	COG4988	ABC transporter
C248_RS03790	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C248_RS03800	COG0523	cobalamin synthesis protein
C248_RS03805	COG4989	oxidoreductase activity
C248_RS03815	COG0471	metal ion transport
C248_RS03820	COG0415	Belongs to the DNA photolyase family
C248_RS03850	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C248_RS03855	COG1349	DNA-binding transcription factor activity
C248_RS03860	COG1105	Belongs to the carbohydrate kinase PfkB family
C248_RS03865	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C248_RS03865	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C248_RS03865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C248_RS03875	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C248_RS03880	COG1253	flavin adenine dinucleotide binding
C248_RS03885	COG0656	L-ascorbic acid biosynthetic process
C248_RS03890	COG0463	Glycosyl transferase, family 2
C248_RS03925	COG0720	synthase
C248_RS03935	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C248_RS03935	COG0512	Glutamine amidotransferase of anthranilate synthase
C248_RS03940	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C248_RS03975	COG0488	(ABC) transporter
C248_RS03980	COG0514	ATP-dependent DNA helicase (RecQ)
C248_RS03985	COG0517	IMP dehydrogenase activity
C248_RS03985	COG1125	glycine betaine transport
C248_RS03990	COG1174	glycine betaine transport
C248_RS04020	COG3104	oligopeptide transport
C248_RS04040	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C248_RS04045	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C248_RS04055	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C248_RS04060	COG4605	iron ion homeostasis
C248_RS04065	COG4604	ABC transporter, ATP-binding protein
C248_RS04070	COG4607	ABC-type enterochelin transport system periplasmic component
C248_RS04125	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C248_RS04130	COG1739	Uncharacterized protein family UPF0029
C248_RS04140	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
C248_RS04145	COG1040	competence protein
C248_RS04175	COG1388	LysM domain
C248_RS04175	COG3942	CHAP domain
C248_RS04235	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C248_RS04255	COG0281	malic enzyme
C248_RS04305	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C248_RS04310	COG1647	Serine aminopeptidase, S33
C248_RS04315	COG0557	exoribonuclease II activity
C248_RS04375	COG1278	Cold shock
C248_RS04420	COG1279	arginine transmembrane transporter activity
C248_RS04445	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C248_RS04450	COG1393	Belongs to the ArsC family
C248_RS04465	COG3878	Protein conserved in bacteria
C248_RS04470	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C248_RS04485	COG2011	ABC-type metal ion transport system permease component
C248_RS04490	COG1464	Belongs to the NlpA lipoprotein family
C248_RS04505	COG0396	ATPase activity
C248_RS04510	COG0719	Fe-S assembly protein
C248_RS04520	COG0822	iron-sulfur transferase activity
C248_RS04540	COG1253	flavin adenine dinucleotide binding
C248_RS04550	COG1801	Protein of unknown function DUF72
C248_RS04555	COG0730	response to heat
C248_RS04570	COG4470	Protein conserved in bacteria
C248_RS04580	COG2445	Protein of unknown function DUF86
C248_RS04610	COG1696	Membrane protein involved in D-alanine export
C248_RS04620	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
C248_RS04625	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C248_RS04630	COG4837	Protein of unknown function (DUF1462)
C248_RS04635	COG1252	NADH dehydrogenase
C248_RS04645	COG0316	Belongs to the HesB IscA family
C248_RS04655	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C248_RS04660	COG2056	Na+-H+ antiporter family
C248_RS04665	COG2050	protein possibly involved in aromatic compounds catabolism
C248_RS04720	COG1098	S1 RNA binding domain
C248_RS04725	COG1902	pentaerythritol trinitrate reductase activity
C248_RS04745	COG0584	glycerophosphoryl diester phosphodiesterase
C248_RS04765	COG0398	Pfam SNARE associated Golgi protein
C248_RS04840	COG0791	NLP P60 protein
C248_RS04840	COG0741	lytic transglycosylase activity
C248_RS04870	COG2946	Replication initiation factor
C248_RS04880	COG1674	ftsk spoiiie
C248_RS04905	COG0561	phosphatase activity
C248_RS04930	COG1881	PFAM PEBP family protein
C248_RS04960	COG0601	transmembrane transport
C248_RS04965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C248_RS04970	COG0444	Belongs to the ABC transporter superfamily
C248_RS04975	COG4608	Belongs to the ABC transporter superfamily
C248_RS04980	COG4166	transmembrane transport
C248_RS04985	COG0601	transmembrane transport
C248_RS04990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C248_RS04995	COG0444	Belongs to the ABC transporter superfamily
C248_RS05000	COG4608	Belongs to the ABC transporter superfamily
C248_RS05005	COG4166	transmembrane transport
C248_RS05030	COG1164	Oligoendopeptidase f
C248_RS05040	COG2346	COG2346, Truncated hemoglobins
C248_RS05055	COG2357	RelA SpoT domain protein
C248_RS05065	COG0564	pseudouridine synthase activity
C248_RS05070	COG2239	Acts as a magnesium transporter
C248_RS05075	COG0475	glutathione-regulated potassium exporter activity
C248_RS05075	COG0569	domain protein
C248_RS05085	COG0628	permease
C248_RS05090	COG1115	amino acid carrier protein
C248_RS05130	COG0861	Integral membrane protein TerC family
C248_RS05140	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C248_RS05145	COG0737	Belongs to the 5'-nucleotidase family
C248_RS05160	COG4903	ComK protein
C248_RS05175	COG4873	Protein conserved in bacteria
C248_RS05220	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
C248_RS05230	COG2314	TM2 domain
C248_RS05235	COG0456	acetyltransferase
C248_RS05240	COG1575	Belongs to the MenA family. Type 1 subfamily
C248_RS05245	COG1169	isochorismate synthase
C248_RS05285	COG0436	Aminotransferase
C248_RS05290	COG3594	Acyltransferase
C248_RS05320	COG1316	TRANSCRIPTIONal
C248_RS05365	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C248_RS05380	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C248_RS05420	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C248_RS05425	COG4172	Belongs to the ABC transporter superfamily
C248_RS05430	COG4721	ABC-type cobalt transport system, permease component
C248_RS05450	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C248_RS05475	COG1271	oxidase subunit
C248_RS05480	COG1294	oxidase, subunit
C248_RS05485	COG0569	domain protein
C248_RS05555	COG1176	ABC-type spermidine putrescine transport system, permease component I
C248_RS05560	COG1177	transmembrane transport
C248_RS05565	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C248_RS05590	COG0483	inositol monophosphate 1-phosphatase activity
C248_RS05600	COG1217	gtp-binding protein TYPA
C248_RS05610	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C248_RS05620	COG0772	Belongs to the SEDS family
C248_RS05655	COG3679	Belongs to the UPF0342 family
C248_RS05675	COG0742	ribosomal rna small subunit methyltransferase
C248_RS05735	COG4509	Sortase family
C248_RS05750	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C248_RS05780	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C248_RS05780	COG1796	DNA polymerase
C248_RS05805	COG2009	succinate dehydrogenase
C248_RS05810	COG1053	succinate dehydrogenase
C248_RS05815	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C248_RS05930	COG1288	antiporter activity
C248_RS05965	COG1011	Hydrolase
C248_RS05990	COG4839	cell division protein FtsL
C248_RS05995	COG0768	penicillin binding
C248_RS06010	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C248_RS06015	COG0849	cell division
C248_RS06030	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C248_RS06040	COG0762	integral membrane protein
C248_RS06045	COG2302	S4 RNA-binding domain
C248_RS06050	COG3599	regulation of cell shape
C248_RS06060	COG2514	catechol 2,3-dioxygenase activity
C248_RS06070	COG0564	pseudouridine synthase activity
C248_RS06080	COG2233	PERMEase
C248_RS06125	COG1293	RNA-binding protein homologous to eukaryotic snRNP
C248_RS06140	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C248_RS06145	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C248_RS06155	COG2314	TM2 domain
C248_RS06170	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C248_RS06170	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C248_RS06180	COG0631	protein serine/threonine phosphatase activity
C248_RS06195	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C248_RS06210	COG1302	Protein conserved in bacteria
C248_RS06260	COG1196	nuclear chromosome segregation
C248_RS06265	COG0552	protein localization to endoplasmic reticulum
C248_RS06275	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C248_RS06340	COG0758	DNA mediated transformation
C248_RS06435	COG0195	Participates in both transcription termination and antitermination
C248_RS06440	COG2740	Nucleic-acid-binding protein implicated in transcription termination
C248_RS06465	COG0196	riboflavin kinase activity
C248_RS06490	COG2188	Transcriptional regulator
C248_RS06495	COG0612	Peptidase, M16
C248_RS06500	COG0612	Peptidase, M16
C248_RS06505	COG0300	oxidoreductase activity
C248_RS06525	COG1058	Belongs to the CinA family
C248_RS06525	COG1546	Belongs to the CinA family
C248_RS06545	COG1692	metallophosphoesterase
C248_RS06550	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C248_RS06550	COG0674	pyruvate-flavodoxin oxidoreductase activity
C248_RS06555	COG1013	pyruvate-flavodoxin oxidoreductase activity
C248_RS06560	COG2826	transposase and inactivated derivatives, IS30 family
C248_RS06595	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
C248_RS06600	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C248_RS06625	COG1923	regulation of RNA biosynthetic process
C248_RS06635	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C248_RS06640	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
C248_RS06645	COG0789	Transcriptional regulator
C248_RS06685	COG2826	transposase and inactivated derivatives, IS30 family
C248_RS06745	COG1525	nuclease
C248_RS06760	COG0527	aspartate kinase activity
C248_RS06765	COG0460	homoserine dehydrogenase
C248_RS06770	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C248_RS06795	COG0833	amino acid
C248_RS06825	COG2340	Cysteine-rich secretory protein family
C248_RS06860	COG4846	Membrane protein involved in cytochrome C biogenesis
C248_RS06880	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C248_RS06895	COG0824	Thioesterase
C248_RS06915	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C248_RS06925	COG1115	amino acid carrier protein
C248_RS06940	COG0628	permease
C248_RS06965	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C248_RS06975	COG1363	Peptidase, m42
C248_RS06980	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C248_RS06985	COG0512	Glutamine amidotransferase of anthranilate synthase
C248_RS07025	COG0561	phosphatase activity
C248_RS07080	COG0704	Plays a role in the regulation of phosphate uptake
C248_RS07090	COG0581	inorganic phosphate transmembrane transporter activity
C248_RS07095	COG0573	inorganic phosphate transmembrane transporter activity
C248_RS07115	COG0488	(ABC) transporter
C248_RS07120	COG0527	aspartate kinase activity
C248_RS07125	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C248_RS07160	COG2808	Putative FMN-binding domain
C248_RS07205	COG4548	von Willebrand factor, type A
C248_RS07210	COG0714	Associated with various cellular activities
C248_RS07255	COG0671	phosphoesterase, PA-phosphatase related
C248_RS07335	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C248_RS07360	COG0531	amino acid
C248_RS07375	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C248_RS07380	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C248_RS07395	COG0116	Belongs to the methyltransferase superfamily
C248_RS07425	COG4499	WXG100 protein secretion system (Wss), protein YukC
C248_RS07425	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C248_RS07435	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C248_RS07440	COG3935	DnaD domain protein
C248_RS07465	COG0438	transferase activity, transferring glycosyl groups
C248_RS07470	COG1694	Mazg nucleotide pyrophosphohydrolase
C248_RS07475	COG2738	Putative neutral zinc metallopeptidase
C248_RS07480	COG4347	Protein of unknown function (DUF1405)
C248_RS07585	COG0492	ferredoxin-NADP+ reductase activity
C248_RS07600	COG0514	ATP-dependent DNA helicase (RecQ)
C248_RS07610	COG1141	Ferredoxin
C248_RS07655	COG5002	protein histidine kinase activity
C248_RS07660	COG0745	RESPONSE REGULATOR receiver
C248_RS07665	COG1187	pseudouridine synthase activity
C248_RS07690	COG0735	belongs to the Fur family
C248_RS07695	COG0494	nUDIX hydrolase
C248_RS07700	COG0667	Aldo Keto reductase
C248_RS07725	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C248_RS07735	COG0366	Alpha amylase catalytic
C248_RS07740	COG1609	Transcriptional regulator
C248_RS07760	COG2195	Cleaves the N-terminal amino acid of tripeptides
C248_RS07770	COG4129	membrane
C248_RS07780	COG0508	dehydrogenase complex catalyzes the overall conversion of
C248_RS07785	COG0022	dehydrogenase e1 component
C248_RS07790	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C248_RS07795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C248_RS07800	COG0497	DNA recombination
C248_RS07830	COG1302	Protein conserved in bacteria
C248_RS07835	COG0439	Biotin carboxylase
C248_RS07840	COG0511	ligase activity, forming carbon-carbon bonds
C248_RS07850	COG0006	proline dipeptidase activity
C248_RS07865	COG0095	Lipoate-protein ligase
C248_RS07870	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C248_RS07915	COG4537	Required for transformation and DNA binding
C248_RS07920	COG1459	type II secretion system
C248_RS07925	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C248_RS07930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C248_RS07935	COG0011	TIGRFAM Protein of
C248_RS07940	COG1940	carbohydrate kinase activity
C248_RS07945	COG4483	Protein conserved in bacteria
C248_RS07955	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C248_RS07965	COG0768	penicillin binding
C248_RS07980	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C248_RS07985	COG1121	(ABC) transporter
C248_RS07995	COG0513	Belongs to the DEAD box helicase family
C248_RS08005	COG2384	SAM-dependent methyltransferase
C248_RS08025	COG0517	IMP dehydrogenase activity
C248_RS08045	COG0295	cytidine deaminase activity
C248_RS08060	COG1702	phosphate starvation-inducible protein PhoH
C248_RS08075	COG1030	water channel activity
C248_RS08085	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C248_RS08090	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C248_RS08120	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C248_RS08140	COG1466	dna polymerase III delta subunit
C248_RS08145	COG0658	competence protein
C248_RS08145	COG2333	competence protein COMEC
C248_RS08150	COG2131	deaminase
C248_RS08160	COG2226	methyltransferase
C248_RS08165	COG0799	negative regulation of ribosome biogenesis
C248_RS08170	COG1713	HD superfamily hydrolase involved in NAD metabolism
C248_RS08180	COG1534	Rna-binding protein
C248_RS08190	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C248_RS08195	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
C248_RS08220	COG3177	Filamentation induced by cAMP protein fic
C248_RS08225	COG1914	H( )-stimulated, divalent metal cation uptake system
C248_RS08235	COG0439	Biotin carboxylase
C248_RS08240	COG0511	ligase activity, forming carbon-carbon bonds
C248_RS08245	COG1984	allophanate hydrolase subunit 2
C248_RS08250	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C248_RS08265	COG0826	peptidase U32
C248_RS08270	COG0826	peptidase U32
C248_RS08300	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C248_RS08315	COG1104	cysteine desulfurase activity
C248_RS08320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C248_RS08330	COG3237	CsbD-like
C248_RS08335	COG1959	2 iron, 2 sulfur cluster binding
C248_RS08340	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C248_RS08345	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C248_RS08385	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C248_RS08385	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C248_RS08390	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C248_RS08390	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C248_RS08395	COG1862	Preprotein translocase
C248_RS08435	COG2868	ribosomal protein
C248_RS08470	COG0488	(ABC) transporter
C248_RS08495	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C248_RS08505	COG0285	dihydrofolate synthase activity
C248_RS08515	COG2818	Glycosylase
C248_RS08550	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C248_RS08585	COG4112	unkown
C248_RS08610	COG0833	amino acid
C248_RS08625	COG1484	DNA-dependent DNA replication
C248_RS08655	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C248_RS08655	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C248_RS08665	COG5002	protein histidine kinase activity
C248_RS08670	COG0745	RESPONSE REGULATOR receiver
C248_RS08685	COG0372	Belongs to the citrate synthase family
C248_RS08690	COG1113	amino acid transport
C248_RS08715	COG0281	malic enzyme
C248_RS08725	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C248_RS08735	COG4109	DRTGG domain
C248_RS08780	COG0827	DNA restriction-modification system
C248_RS08790	COG0730	response to heat
C248_RS08800	COG1104	cysteine desulfurase activity
C248_RS08810	COG1956	GAF domain-containing protein
C248_RS08825	COG0584	glycerophosphoryl diester phosphodiesterase
C248_RS08830	COG1764	response to oxidative stress
C248_RS08835	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C248_RS08840	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C248_RS08855	COG1263	PTS System
C248_RS08855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C248_RS08860	COG0204	Acyl-transferase
C248_RS08865	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C248_RS08885	COG5386	Cell surface protein
C248_RS08900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C248_RS08905	COG0454	-acetyltransferase
C248_RS08925	COG1605	Chorismate mutase
C248_RS08925	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C248_RS08950	COG1674	ftsk spoiiie
C248_RS08955	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C248_RS08965	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C248_RS08970	COG1363	Peptidase, m42
C248_RS08980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C248_RS08995	COG0510	thiamine kinase activity
C248_RS09015	COG1187	pseudouridine synthase activity
C248_RS09020	COG2244	polysaccharide biosynthetic process
C248_RS09025	COG2081	HI0933 family
C248_RS09045	COG2814	Major facilitator Superfamily
C248_RS09050	COG1242	4 iron, 4 sulfur cluster binding
C248_RS09055	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C248_RS09065	COG2267	carboxylic ester hydrolase activity
C248_RS09095	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C248_RS09095	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C248_RS09115	COG3266	domain, Protein
C248_RS09115	COG4193	domain, Protein
C248_RS09115	COG5632	N-Acetylmuramoyl-L-alanine amidase
C248_RS09150	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C248_RS09170	COG0656	L-ascorbic acid biosynthetic process
C248_RS09190	COG1506	peptidase
C248_RS09195	COG2816	NAD+ diphosphatase activity
C248_RS09285	COG5492	domain, Protein
C248_RS09375	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
C248_RS09405	COG1131	(ABC) transporter
C248_RS09410	COG0537	adenosine 5'-monophosphoramidase activity
C248_RS09440	COG0420	3'-5' exonuclease activity
C248_RS09465	COG2197	response regulator
C248_RS09470	COG4585	Histidine kinase
C248_RS09470	COG2203	Gaf domain
C248_RS09475	COG0564	pseudouridine synthase activity
C248_RS09510	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C248_RS09515	COG1126	abc transporter atp-binding protein
C248_RS09520	COG0765	amino acid transport
C248_RS09675	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C248_RS09680	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C248_RS09690	COG4129	membrane
C248_RS09710	COG1194	a g-specific adenine glycosylase
C248_RS09715	COG1988	membrane-bound metal-dependent
C248_RS09730	COG1134	teichoic acid transport
C248_RS09730	COG1388	LysM domain
C248_RS09760	COG0535	radical SAM domain protein
C248_RS09765	COG1607	acyl-coa hydrolase
C248_RS09770	COG2309	aminopeptidase activity
C248_RS09790	COG1295	ribonuclease BN
C248_RS09915	COG4851	CamS sex pheromone cAM373 precursor
C248_RS09935	COG4496	protein, YerC YecD
C248_RS09970	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C248_RS09980	COG0077	Prephenate dehydratase
C248_RS10000	COG1335	isochorismatase
C248_RS10015	COG1012	belongs to the aldehyde dehydrogenase family
C248_RS10025	COG3682	Transcriptional regulator
C248_RS10055	COG4974	Belongs to the 'phage' integrase family
C248_RS10105	COG1131	(ABC) transporter
C248_RS10120	COG1725	Transcriptional regulator
C248_RS10170	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C248_RS10240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C248_RS10245	COG1621	beta-fructofuranosidase activity
C248_RS10250	COG1609	Transcriptional regulator
C248_RS10255	COG0004	ammonium transporteR
C248_RS10260	COG0425	Belongs to the sulfur carrier protein TusA family
C248_RS10265	COG2391	methyltransferase activity
C248_RS10275	COG0488	(ABC) transporter
C248_RS10285	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C248_RS10295	COG0456	acetyltransferase
C248_RS10300	COG1214	PFAM Peptidase M22, glycoprotease
C248_RS10305	COG0802	atpase or kinase
C248_RS10320	COG0028	Belongs to the TPP enzyme family
C248_RS10395	COG2183	response to ionizing radiation
C248_RS10400	COG1191	sigma factor activity
C248_RS10410	COG1366	Belongs to the anti-sigma-factor antagonist family
C248_RS10415	COG2208	phosphoserine phosphatase activity
C248_RS10450	COG3428	Bacterial PH domain
C248_RS10480	COG2205	protein histidine kinase activity
C248_RS10485	COG0745	RESPONSE REGULATOR receiver
C248_RS10495	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C248_RS10505	COG0772	Belongs to the SEDS family
C248_RS10520	COG1937	Protein conserved in bacteria
C248_RS10530	COG1418	mRNA catabolic process
C248_RS10585	COG0629	single-stranded DNA binding
C248_RS10655	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C248_RS10680	COG0009	L-threonylcarbamoyladenylate synthase
C248_RS10685	COG2890	protein-(glutamine-N5) methyltransferase activity
C248_RS10705	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C248_RS10745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C248_RS10800	COG0813	purine-nucleoside phosphorylase activity
C248_RS10805	COG0783	Belongs to the Dps family
C248_RS10825	COG1482	cell wall glycoprotein biosynthetic process
C248_RS10830	COG0702	epimerase
C248_RS10835	COG0640	Transcriptional regulator
C248_RS10860	COG0561	phosphatase activity
C248_RS10865	COG1119	ATPase activity
C248_RS10885	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C248_RS10950	COG3711	transcriptional antiterminator
C248_RS10980	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C248_RS11040	COG0489	protein tyrosine kinase activity
C248_RS11045	COG2814	Major facilitator Superfamily
C248_RS11060	COG1272	protein, Hemolysin III
C248_RS11070	COG1988	membrane-bound metal-dependent
C248_RS11080	COG3314	Sporulation integral membrane protein YlbJ
C248_RS11085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C248_RS11090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C248_RS11095	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
C248_RS11105	COG3457	Alanine racemase
C248_RS11110	COG4264	IucA IucC family
C248_RS11115	COG2814	Major facilitator Superfamily
C248_RS11140	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C248_RS11150	COG2130	NADP-dependent
C248_RS11220	COG0656	L-ascorbic acid biosynthetic process
C248_RS11225	COG0789	Transcriptional regulator
C248_RS11235	COG5492	domain, Protein
C248_RS11245	COG0438	transferase activity, transferring glycosyl groups
C248_RS11260	COG3527	Alpha-acetolactate decarboxylase
C248_RS11265	COG0028	Belongs to the TPP enzyme family
C248_RS11270	COG2826	transposase and inactivated derivatives, IS30 family
C248_RS11345	COG0201	protein transport
C248_RS11460	COG2252	PERMEase
C248_RS11505	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C248_RS11570	COG1763	Mo-molybdopterin cofactor biosynthetic process
C248_RS11590	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C248_RS11595	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C248_RS11600	COG4149	molybdate abc transporter
C248_RS11605	COG0725	ABC transporter, periplasmic molybdate-binding protein
C248_RS11620	COG1268	BioY protein
C248_RS11635	COG1960	acyl-CoA dehydrogenase activity
C248_RS11640	COG4413	Urea transporter
C248_RS11715	COG1757	Na H antiporter
C248_RS11730	COG3942	CHAP domain
C248_RS11790	COG1266	CAAX protease self-immunity
C248_RS11805	COG1113	amino acid transport
C248_RS11825	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C248_RS11830	COG0385	Bile acid
C248_RS11840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C248_RS11840	COG1263	PTS System
C248_RS11845	COG1737	Transcriptional regulator
C248_RS11865	COG1028	Short-chain dehydrogenase reductase Sdr
C248_RS11870	COG1473	amidohydrolase
C248_RS11885	COG0583	DNA-binding transcription factor activity
C248_RS11905	COG2258	MOSC domain
C248_RS11925	COG1668	transmembrane transport
C248_RS11930	COG4152	abc transporter atp-binding protein
C248_RS11935	COG3152	Membrane
C248_RS11945	COG0786	glutamate:sodium symporter activity
C248_RS11955	COG0598	Magnesium transport protein CorA
C248_RS11970	COG0657	acetylesterase activity
C248_RS11980	COG2814	Major facilitator Superfamily
C248_RS11985	COG1566	PFAM secretion protein HlyD family protein
C248_RS12000	COG2814	Major facilitator Superfamily
C248_RS12065	COG1620	l-lactate permease
C248_RS12075	COG2826	transposase and inactivated derivatives, IS30 family
C248_RS12090	COG0604	alcohol dehydrogenase
C248_RS12120	COG1511	domain protein
C248_RS12135	COG1263	PTS System
C248_RS12135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C248_RS12150	COG3871	stress protein (general stress protein 26)
C248_RS12190	COG0789	Transcriptional regulator
C248_RS12210	COG2181	nitrate reductase activity
C248_RS12220	COG1140	nitrate reductase beta subunit
C248_RS12225	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C248_RS12235	COG2146	nitrite reductase [NAD(P)H] activity
C248_RS12240	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C248_RS12250	COG0454	-acetyltransferase
C248_RS12255	COG2116	formate transmembrane transporter activity
C248_RS12270	COG0803	Belongs to the bacterial solute-binding protein 9 family
C248_RS12270	COG3443	Belongs to the bacterial solute-binding protein 9 family
C248_RS12295	COG1126	abc transporter atp-binding protein
C248_RS12300	COG0765	amino acid transport
C248_RS12305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C248_RS12310	COG2814	Major facilitator Superfamily
C248_RS12325	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C248_RS12370	COG0156	8-amino-7-oxononanoate synthase activity
C248_RS12380	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C248_RS12385	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C248_RS12400	COG1132	(ABC) transporter
C248_RS12405	COG1132	(ABC) transporter
C248_RS12405	COG2375	cellular response to nickel ion
C248_RS12425	COG1929	Belongs to the glycerate kinase type-1 family
C248_RS12435	COG2814	Major facilitator Superfamily
C248_RS12455	COG1113	amino acid transport
C248_RS12465	COG0531	amino acid
C248_RS12490	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C248_RS12500	COG1174	glycine betaine transport
C248_RS12510	COG1174	glycine betaine transport
C248_RS12530	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
C248_RS12535	COG0531	amino acid
C248_RS12540	COG2272	Belongs to the type-B carboxylesterase lipase family
C248_RS12545	COG2814	Major facilitator Superfamily
C248_RS12550	COG0390	transport system, permease component
C248_RS12555	COG4619	ABC transporter
C248_RS12560	COG1363	Peptidase, m42
C248_RS12565	COG4808	Protein conserved in bacteria
C248_RS12570	COG0069	glutamate synthase activity
C248_RS12585	COG1124	(ABC) transporter
C248_RS12595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C248_RS12600	COG0601	transmembrane transport
C248_RS12605	COG0747	negative chemotaxis
C248_RS12630	COG1028	Short-chain dehydrogenase reductase Sdr
C248_RS12635	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C248_RS12640	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C248_RS12795	COG1070	Carbohydrate kinase
C248_RS12800	COG1802	Transcriptional regulator
C248_RS12805	COG0789	Transcriptional regulator
C248_RS12810	COG2357	RelA SpoT domain protein
C248_RS12815	COG4876	unkown
C248_RS12825	COG2271	Major facilitator Superfamily
C248_RS12830	COG0586	Pfam SNARE associated Golgi protein
C248_RS12840	COG2814	Major facilitator Superfamily
C248_RS12845	COG1846	Transcriptional regulator
C248_RS12850	COG1131	(ABC) transporter
C248_RS12870	COG3949	Membrane
C248_RS12875	COG0400	carboxylic ester hydrolase activity
C248_RS12880	COG0346	lactoylglutathione lyase activity
C248_RS12885	COG1846	Transcriptional regulator
C248_RS12895	COG2514	catechol 2,3-dioxygenase activity
C248_RS12910	COG0561	phosphatase activity
C248_RS12915	COG3764	Sortase (surface protein transpeptidase)
C248_RS12935	COG1760	l-serine dehydratase
C248_RS12940	COG1760	l-serine dehydratase
C248_RS12955	COG0697	spore germination
C248_RS12960	COG0657	acetylesterase activity
C248_RS12980	COG0028	Belongs to the TPP enzyme family
C248_RS12995	COG0583	DNA-binding transcription factor activity
C248_RS13005	COG3942	CHAP domain
C248_RS13015	COG3425	synthase
C248_RS13020	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C248_RS13045	COG2409	Drug exporters of the RND superfamily
C248_RS13090	COG0436	Aminotransferase
C248_RS13195	COG0596	Alpha beta hydrolase
C248_RS13230	COG3001	Fructosamine kinase
C248_RS13235	COG0167	dihydroorotate dehydrogenase activity
C248_RS13285	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C248_RS13290	COG3527	Alpha-acetolactate decarboxylase
C248_RS13305	COG0531	amino acid
C248_RS13335	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C248_RS13355	COG1012	belongs to the aldehyde dehydrogenase family
C248_RS13365	COG1510	regulation of RNA biosynthetic process
C248_RS13370	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C248_RS13395	COG2851	Citrate transporter
C248_RS13410	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C248_RS13420	COG0386	Belongs to the glutathione peroxidase family
C248_RS13445	COG1136	(ABC) transporter
C248_RS13450	COG2205	protein histidine kinase activity
C248_RS13455	COG0745	RESPONSE REGULATOR receiver
C248_RS13470	COG1785	Belongs to the alkaline phosphatase family
C248_RS13475	COG1846	Transcriptional regulator
C248_RS13520	COG1438	arginine binding
C248_RS13540	COG3711	transcriptional antiterminator
C248_RS13540	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C248_RS13545	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C248_RS13545	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C248_RS13545	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C248_RS13550	COG1482	cell wall glycoprotein biosynthetic process
C248_RS13560	COG1705	Flagellar rod assembly protein muramidase FlgJ
C248_RS13560	COG3942	CHAP domain
C248_RS13565	COG3433	isochorismatase activity
C248_RS13565	COG1535	isochorismatase
C248_RS13580	COG0438	transferase activity, transferring glycosyl groups
C248_RS13595	COG1073	alpha beta
C248_RS13615	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C248_RS13645	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C248_RS13735	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C248_RS13800	COG0471	metal ion transport
C248_RS13805	COG2962	Rard protein
C248_RS13815	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
C248_RS13830	COG1136	(ABC) transporter
C248_RS13835	COG0577	efflux transmembrane transporter activity
C248_RS13845	COG1278	Cold shock
C248_RS13865	COG1475	DNA binding