locus-tag	class	description
B4603_RS00015	COG2501	S4 domain
B4603_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B4603_RS00065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B4603_RS00075	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
B4603_RS00085	COG0305	Participates in initiation and elongation during chromosome replication
B4603_RS00125	COG4863	YycH protein
B4603_RS00135	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B4603_RS00140	COG0737	Belongs to the 5'-nucleotidase family
B4603_RS00165	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4603_RS00165	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4603_RS00205	COG3425	synthase
B4603_RS00215	COG0584	glycerophosphoryl diester phosphodiesterase
B4603_RS00220	COG2030	dehydratase
B4603_RS00310	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B4603_RS00330	COG0640	Transcriptional regulator
B4603_RS00335	COG2217	Heavy metal translocating P-type atpase
B4603_RS00340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4603_RS00345	COG2210	Belongs to the sulfur carrier protein TusA family
B4603_RS00350	COG1937	Protein conserved in bacteria
B4603_RS00355	COG0730	response to heat
B4603_RS00360	COG2217	Heavy metal translocating P-type atpase
B4603_RS00365	COG1388	LysM domain
B4603_RS00435	COG2814	Major facilitator Superfamily
B4603_RS00460	COG0456	acetyltransferase
B4603_RS00485	COG0655	NAD(P)H dehydrogenase (quinone) activity
B4603_RS00500	COG1073	alpha beta
B4603_RS00510	COG2226	methyltransferase
B4603_RS00520	COG0823	Involved in the tonB-independent uptake of proteins
B4603_RS00535	COG1473	amidohydrolase
B4603_RS00545	COG1283	sodium-dependent phosphate transmembrane transporter activity
B4603_RS00550	COG4716	Myosin-crossreactive antigen
B4603_RS00560	COG1620	l-lactate permease
B4603_RS00580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4603_RS00585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4603_RS00590	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B4603_RS00600	COG2423	ornithine cyclodeaminase activity
B4603_RS00605	COG4264	IucA IucC family
B4603_RS00610	COG2814	Major facilitator Superfamily
B4603_RS00615	COG4264	IucA IucC family
B4603_RS00620	COG4264	IucA IucC family
B4603_RS00630	COG0019	diaminopimelate decarboxylase activity
B4603_RS00635	COG1475	DNA binding
B4603_RS00665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B4603_RS00670	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B4603_RS00675	COG0438	transferase activity, transferring glycosyl groups
B4603_RS00705	COG0813	purine-nucleoside phosphorylase activity
B4603_RS00710	COG2814	Major facilitator Superfamily
B4603_RS00730	COG3639	organic phosphonate transmembrane transporter activity
B4603_RS00750	COG0737	Belongs to the 5'-nucleotidase family
B4603_RS00765	COG1012	belongs to the aldehyde dehydrogenase family
B4603_RS00765	COG1454	alcohol dehydrogenase
B4603_RS00790	COG1086	Polysaccharide biosynthesis protein
B4603_RS00800	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B4603_RS00830	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B4603_RS00840	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
B4603_RS00845	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B4603_RS00855	COG2832	Protein of unknown function (DUF454)
B4603_RS00890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B4603_RS00895	COG1960	acyl-CoA dehydrogenase activity
B4603_RS00900	COG5609	conserved protein (DUF2294)
B4603_RS00925	COG2826	transposase and inactivated derivatives, IS30 family
B4603_RS00960	COG1309	transcriptional regulator
B4603_RS00965	COG1114	Component of the transport system for branched-chain amino acids
B4603_RS00970	COG1335	isochorismatase
B4603_RS00975	COG3961	Belongs to the TPP enzyme family
B4603_RS01005	COG1737	Transcriptional regulator
B4603_RS01030	COG0601	transmembrane transport
B4603_RS01035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B4603_RS01045	COG0405	Gamma-glutamyltransferase
B4603_RS01065	COG3842	ATPase activity
B4603_RS01075	COG1175	transmembrane transport
B4603_RS01080	COG3833	ABC-type maltose transport systems, permease component
B4603_RS01085	COG0673	inositol 2-dehydrogenase activity
B4603_RS01090	COG0673	inositol 2-dehydrogenase activity
B4603_RS01100	COG1755	Isoprenylcysteine carboxyl methyltransferase
B4603_RS01155	COG0183	Belongs to the thiolase family
B4603_RS01165	COG1960	acyl-CoA dehydrogenase activity
B4603_RS01170	COG0318	PFAM AMP-dependent synthetase and ligase
B4603_RS01190	COG0747	negative chemotaxis
B4603_RS01195	COG3189	MarR family transcriptional regulator
B4603_RS01230	COG1263	PTS System
B4603_RS01230	COG2190	(PTS) system
B4603_RS01230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4603_RS01235	COG1957	nucleoside hydrolase
B4603_RS01255	COG3414	Phosphotransferase system galactitol-specific IIB component
B4603_RS01260	COG3775	system Galactitol-specific IIC component
B4603_RS01265	COG1063	alcohol dehydrogenase
B4603_RS01275	COG1063	alcohol dehydrogenase
B4603_RS01285	COG1063	alcohol dehydrogenase
B4603_RS01290	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B4603_RS01305	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B4603_RS01315	COG1063	alcohol dehydrogenase
B4603_RS01320	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B4603_RS01360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4603_RS01370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4603_RS01370	COG1263	PTS System
B4603_RS01370	COG2190	(PTS) system
B4603_RS01375	COG2723	6-phospho-beta-galactosidase activity
B4603_RS01385	COG2226	methyltransferase
B4603_RS01440	COG1131	(ABC) transporter
B4603_RS01460	COG3942	CHAP domain
B4603_RS01460	COG1388	LysM domain
B4603_RS01570	COG1114	Component of the transport system for branched-chain amino acids
B4603_RS01580	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
B4603_RS01590	COG0577	efflux transmembrane transporter activity
B4603_RS01620	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B4603_RS01625	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B4603_RS01650	COG3314	Sporulation integral membrane protein YlbJ
B4603_RS01675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4603_RS01710	COG3037	sugar-specific permease SgaT UlaA
B4603_RS01720	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4603_RS01725	COG3711	transcriptional antiterminator
B4603_RS01750	COG2271	Major facilitator Superfamily
B4603_RS01755	COG0346	lactoylglutathione lyase activity
B4603_RS01760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4603_RS01765	COG0431	NADPH-dependent FMN reductase
B4603_RS01785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4603_RS01790	COG2822	iron ion transport
B4603_RS01800	COG0672	)-iron permease
B4603_RS01810	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B4603_RS01820	COG1476	TRANSCRIPTIONal
B4603_RS01830	COG1131	(ABC) transporter
B4603_RS01860	COG0646	methionine synthase
B4603_RS01860	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B4603_RS01865	COG0626	cystathionine gamma-synthase activity
B4603_RS01870	COG0626	cystathionine gamma-synthase activity
B4603_RS01880	COG1475	DNA binding
B4603_RS01885	COG0668	transmembrane transport
B4603_RS01890	COG4481	Protein conserved in bacteria
B4603_RS01895	COG0012	GTP binding
B4603_RS01995	COG1823	symporter activity
B4603_RS02030	COG2233	PERMEase
B4603_RS02045	COG0582	viral genome integration into host DNA
B4603_RS02110	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B4603_RS02155	COG3759	membrane
B4603_RS02295	COG0523	cobalamin synthesis protein
B4603_RS02310	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B4603_RS02320	COG5609	conserved protein (DUF2294)
B4603_RS02335	COG1647	Serine aminopeptidase, S33
B4603_RS02340	COG0733	neurotransmitter:sodium symporter activity
B4603_RS02345	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B4603_RS02350	COG0626	cystathionine gamma-synthase activity
B4603_RS02360	COG2011	ABC-type metal ion transport system permease component
B4603_RS02365	COG1464	Belongs to the NlpA lipoprotein family
B4603_RS02400	COG0583	DNA-binding transcription factor activity
B4603_RS02405	COG0070	glutamate synthase
B4603_RS02405	COG0067	glutamate synthase
B4603_RS02405	COG0069	glutamate synthase activity
B4603_RS02410	COG0493	'glutamate synthase
B4603_RS02425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4603_RS02425	COG1263	PTS System
B4603_RS02430	COG0366	Alpha amylase catalytic
B4603_RS02435	COG2188	Transcriptional regulator
B4603_RS02455	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B4603_RS02490	COG1982	Orn Lys Arg decarboxylase major
B4603_RS02500	COG3870	Protein conserved in bacteria
B4603_RS02505	COG0470	DNA polymerase III
B4603_RS02510	COG1774	PSP1 C-terminal conserved region
B4603_RS02520	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
B4603_RS02530	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
B4603_RS02540	COG0084	hydrolase, TatD family'
B4603_RS02545	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
B4603_RS02555	COG4466	Protein conserved in bacteria
B4603_RS02565	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B4603_RS02570	COG0251	oxidation-reduction process
B4603_RS02615	COG2244	polysaccharide biosynthetic process
B4603_RS02620	COG3956	TIGRFAM MazG family protein
B4603_RS02625	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
B4603_RS02635	COG1098	S1 RNA binding domain
B4603_RS02650	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B4603_RS02675	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B4603_RS02770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4603_RS02790	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B4603_RS02800	COG3880	PFAM UvrB UvrC protein
B4603_RS02815	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
B4603_RS02820	COG4956	integral membrane protein (PIN domain superfamily)
B4603_RS02845	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
B4603_RS02900	COG2813	Specifically methylates the guanine in position
B4603_RS02940	COG1473	amidohydrolase
B4603_RS02975	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
B4603_RS02980	COG1428	Deoxynucleoside kinase
B4603_RS02985	COG1428	Deoxynucleoside kinase
B4603_RS02995	COG0561	phosphatase activity
B4603_RS03030	COG2826	transposase and inactivated derivatives, IS30 family
B4603_RS03045	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B4603_RS03160	COG0095	Lipoate-protein ligase
B4603_RS03165	COG0083	homoserine kinase activity
B4603_RS03185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B4603_RS03265	COG0667	Aldo Keto reductase
B4603_RS03275	COG0655	NAD(P)H dehydrogenase (quinone) activity
B4603_RS03285	COG1078	dGTPase activity
B4603_RS03320	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B4603_RS03325	COG4139	cobalamin transport
B4603_RS03420	COG0803	Belongs to the bacterial solute-binding protein 9 family
B4603_RS03425	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B4603_RS03430	COG1121	(ABC) transporter
B4603_RS03435	COG1321	iron dependent repressor
B4603_RS03445	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
B4603_RS03455	COG1682	transport, permease protein
B4603_RS03460	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B4603_RS03470	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B4603_RS03475	COG1686	Belongs to the peptidase S11 family
B4603_RS03480	COG1132	(ABC) transporter
B4603_RS03485	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B4603_RS03495	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4603_RS03500	COG1120	ATPase activity
B4603_RS03505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4603_RS03510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4603_RS03515	COG2376	Dihydroxyacetone kinase
B4603_RS03535	COG3949	Membrane
B4603_RS03560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B4603_RS03575	COG1136	(ABC) transporter
B4603_RS03580	COG0577	efflux transmembrane transporter activity
B4603_RS03585	COG1392	Phosphate transport regulator
B4603_RS03590	COG0306	phosphate transporter
B4603_RS03595	COG1388	LysM domain
B4603_RS03595	COG3942	CHAP domain
B4603_RS03605	COG1917	Cupin 2, conserved barrel domain protein
B4603_RS03605	COG4977	sequence-specific DNA binding
B4603_RS03635	COG0583	DNA-binding transcription factor activity
B4603_RS03650	COG2814	Major facilitator Superfamily
B4603_RS03655	COG2839	Protein conserved in bacteria
B4603_RS03685	COG1611	Belongs to the LOG family
B4603_RS03705	COG4988	ABC transporter
B4603_RS03710	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B4603_RS03720	COG0523	cobalamin synthesis protein
B4603_RS03725	COG4989	oxidoreductase activity
B4603_RS03735	COG0471	metal ion transport
B4603_RS03740	COG0415	Belongs to the DNA photolyase family
B4603_RS03770	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B4603_RS03775	COG1349	DNA-binding transcription factor activity
B4603_RS03780	COG1105	Belongs to the carbohydrate kinase PfkB family
B4603_RS03785	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B4603_RS03785	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B4603_RS03785	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4603_RS03790	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B4603_RS03795	COG1253	flavin adenine dinucleotide binding
B4603_RS03800	COG0656	L-ascorbic acid biosynthetic process
B4603_RS03805	COG0463	Glycosyl transferase, family 2
B4603_RS03840	COG0720	synthase
B4603_RS03850	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B4603_RS03850	COG0512	Glutamine amidotransferase of anthranilate synthase
B4603_RS03855	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B4603_RS03885	COG0488	(ABC) transporter
B4603_RS03890	COG0514	ATP-dependent DNA helicase (RecQ)
B4603_RS03895	COG1125	glycine betaine transport
B4603_RS03895	COG0517	IMP dehydrogenase activity
B4603_RS03900	COG1174	glycine betaine transport
B4603_RS03935	COG3104	oligopeptide transport
B4603_RS03965	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B4603_RS03970	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B4603_RS03980	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4603_RS03985	COG4605	iron ion homeostasis
B4603_RS03990	COG4604	ABC transporter, ATP-binding protein
B4603_RS03995	COG4607	ABC-type enterochelin transport system periplasmic component
B4603_RS04055	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B4603_RS04060	COG1739	Uncharacterized protein family UPF0029
B4603_RS04070	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
B4603_RS04075	COG1040	competence protein
B4603_RS04105	COG1388	LysM domain
B4603_RS04105	COG3942	CHAP domain
B4603_RS04180	COG0391	Required for morphogenesis under gluconeogenic growth conditions
B4603_RS04200	COG0281	malic enzyme
B4603_RS04255	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B4603_RS04260	COG1647	Serine aminopeptidase, S33
B4603_RS04265	COG0557	exoribonuclease II activity
B4603_RS04330	COG1278	Cold shock
B4603_RS04370	COG0406	alpha-ribazole phosphatase activity
B4603_RS04375	COG1279	arginine transmembrane transporter activity
B4603_RS04400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4603_RS04405	COG1393	Belongs to the ArsC family
B4603_RS04420	COG3878	Protein conserved in bacteria
B4603_RS04435	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
B4603_RS04450	COG2011	ABC-type metal ion transport system permease component
B4603_RS04455	COG1464	Belongs to the NlpA lipoprotein family
B4603_RS04475	COG0396	ATPase activity
B4603_RS04480	COG0719	Fe-S assembly protein
B4603_RS04490	COG0822	iron-sulfur transferase activity
B4603_RS04510	COG1253	flavin adenine dinucleotide binding
B4603_RS04520	COG1801	Protein of unknown function DUF72
B4603_RS04525	COG0730	response to heat
B4603_RS04540	COG4470	Protein conserved in bacteria
B4603_RS04550	COG2445	Protein of unknown function DUF86
B4603_RS04580	COG1696	Membrane protein involved in D-alanine export
B4603_RS04590	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
B4603_RS04595	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
B4603_RS04600	COG4837	Protein of unknown function (DUF1462)
B4603_RS04605	COG1252	NADH dehydrogenase
B4603_RS04615	COG0316	Belongs to the HesB IscA family
B4603_RS04625	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B4603_RS04630	COG2056	Na+-H+ antiporter family
B4603_RS04635	COG2050	protein possibly involved in aromatic compounds catabolism
B4603_RS04690	COG1098	S1 RNA binding domain
B4603_RS04695	COG1902	pentaerythritol trinitrate reductase activity
B4603_RS04715	COG0584	glycerophosphoryl diester phosphodiesterase
B4603_RS04735	COG0398	Pfam SNARE associated Golgi protein
B4603_RS04820	COG0791	NLP P60 protein
B4603_RS04820	COG0741	lytic transglycosylase activity
B4603_RS04850	COG2946	Replication initiation factor
B4603_RS04860	COG1674	ftsk spoiiie
B4603_RS04885	COG0561	phosphatase activity
B4603_RS04915	COG1881	PFAM PEBP family protein
B4603_RS04945	COG0601	transmembrane transport
B4603_RS04950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B4603_RS04955	COG0444	Belongs to the ABC transporter superfamily
B4603_RS04960	COG4608	Belongs to the ABC transporter superfamily
B4603_RS04965	COG4166	transmembrane transport
B4603_RS04970	COG0601	transmembrane transport
B4603_RS04975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B4603_RS04980	COG0444	Belongs to the ABC transporter superfamily
B4603_RS04985	COG4608	Belongs to the ABC transporter superfamily
B4603_RS04990	COG4166	transmembrane transport
B4603_RS05015	COG1164	Oligoendopeptidase f
B4603_RS05025	COG2346	COG2346, Truncated hemoglobins
B4603_RS05040	COG2357	RelA SpoT domain protein
B4603_RS05050	COG0564	pseudouridine synthase activity
B4603_RS05055	COG2239	Acts as a magnesium transporter
B4603_RS05060	COG0475	glutathione-regulated potassium exporter activity
B4603_RS05060	COG0569	domain protein
B4603_RS05070	COG0628	permease
B4603_RS05075	COG1115	amino acid carrier protein
B4603_RS05115	COG0861	Integral membrane protein TerC family
B4603_RS05125	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B4603_RS05130	COG0737	Belongs to the 5'-nucleotidase family
B4603_RS05145	COG4903	ComK protein
B4603_RS05160	COG4873	Protein conserved in bacteria
B4603_RS05210	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
B4603_RS05220	COG2314	TM2 domain
B4603_RS05225	COG0456	acetyltransferase
B4603_RS05230	COG1575	Belongs to the MenA family. Type 1 subfamily
B4603_RS05240	COG1169	isochorismate synthase
B4603_RS05280	COG0436	Aminotransferase
B4603_RS05285	COG3594	Acyltransferase
B4603_RS05315	COG1316	TRANSCRIPTIONal
B4603_RS05365	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B4603_RS05380	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B4603_RS05425	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
B4603_RS05430	COG4172	Belongs to the ABC transporter superfamily
B4603_RS05435	COG4721	ABC-type cobalt transport system, permease component
B4603_RS05460	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B4603_RS05485	COG1271	oxidase subunit
B4603_RS05490	COG1294	oxidase, subunit
B4603_RS05495	COG0569	domain protein
B4603_RS05565	COG1176	ABC-type spermidine putrescine transport system, permease component I
B4603_RS05570	COG1177	transmembrane transport
B4603_RS05575	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B4603_RS05600	COG0483	inositol monophosphate 1-phosphatase activity
B4603_RS05610	COG1217	gtp-binding protein TYPA
B4603_RS05620	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B4603_RS05630	COG0772	Belongs to the SEDS family
B4603_RS05665	COG3679	Belongs to the UPF0342 family
B4603_RS05670	COG0584	glycerophosphoryl diester phosphodiesterase
B4603_RS05685	COG0742	ribosomal rna small subunit methyltransferase
B4603_RS05745	COG4509	Sortase family
B4603_RS05760	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B4603_RS05795	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B4603_RS05795	COG1796	DNA polymerase
B4603_RS05820	COG2009	succinate dehydrogenase
B4603_RS05825	COG1053	succinate dehydrogenase
B4603_RS05830	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B4603_RS05950	COG1288	antiporter activity
B4603_RS05985	COG1011	Hydrolase
B4603_RS06010	COG4839	cell division protein FtsL
B4603_RS06015	COG0768	penicillin binding
B4603_RS06030	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B4603_RS06035	COG0849	cell division
B4603_RS06050	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B4603_RS06060	COG0762	integral membrane protein
B4603_RS06065	COG2302	S4 RNA-binding domain
B4603_RS06070	COG3599	regulation of cell shape
B4603_RS06080	COG2514	catechol 2,3-dioxygenase activity
B4603_RS06090	COG0564	pseudouridine synthase activity
B4603_RS06100	COG2233	PERMEase
B4603_RS06145	COG1293	RNA-binding protein homologous to eukaryotic snRNP
B4603_RS06160	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B4603_RS06165	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B4603_RS06175	COG2314	TM2 domain
B4603_RS06190	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B4603_RS06190	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B4603_RS06200	COG0631	protein serine/threonine phosphatase activity
B4603_RS06215	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B4603_RS06230	COG1302	Protein conserved in bacteria
B4603_RS06280	COG1196	nuclear chromosome segregation
B4603_RS06285	COG0552	protein localization to endoplasmic reticulum
B4603_RS06295	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B4603_RS06360	COG0758	DNA mediated transformation
B4603_RS06460	COG0195	Participates in both transcription termination and antitermination
B4603_RS06465	COG2740	Nucleic-acid-binding protein implicated in transcription termination
B4603_RS06490	COG0196	riboflavin kinase activity
B4603_RS06520	COG2188	Transcriptional regulator
B4603_RS06525	COG0612	Peptidase, M16
B4603_RS06530	COG0612	Peptidase, M16
B4603_RS06535	COG0300	oxidoreductase activity
B4603_RS06555	COG1058	Belongs to the CinA family
B4603_RS06555	COG1546	Belongs to the CinA family
B4603_RS06575	COG1692	metallophosphoesterase
B4603_RS06580	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
B4603_RS06580	COG0674	pyruvate-flavodoxin oxidoreductase activity
B4603_RS06585	COG1013	pyruvate-flavodoxin oxidoreductase activity
B4603_RS06590	COG2826	transposase and inactivated derivatives, IS30 family
B4603_RS06625	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
B4603_RS06630	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B4603_RS06655	COG1923	regulation of RNA biosynthetic process
B4603_RS06665	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B4603_RS06670	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
B4603_RS06675	COG0789	Transcriptional regulator
B4603_RS06760	COG1525	nuclease
B4603_RS06775	COG0527	aspartate kinase activity
B4603_RS06780	COG0460	homoserine dehydrogenase
B4603_RS06785	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B4603_RS06810	COG0833	amino acid
B4603_RS06840	COG2340	Cysteine-rich secretory protein family
B4603_RS06875	COG4846	Membrane protein involved in cytochrome C biogenesis
B4603_RS06895	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B4603_RS06915	COG0824	Thioesterase
B4603_RS06940	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B4603_RS06950	COG1115	amino acid carrier protein
B4603_RS06965	COG0628	permease
B4603_RS06990	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B4603_RS07000	COG1363	Peptidase, m42
B4603_RS07005	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B4603_RS07010	COG0512	Glutamine amidotransferase of anthranilate synthase
B4603_RS07050	COG0561	phosphatase activity
B4603_RS07100	COG0704	Plays a role in the regulation of phosphate uptake
B4603_RS07110	COG0581	inorganic phosphate transmembrane transporter activity
B4603_RS07115	COG0573	inorganic phosphate transmembrane transporter activity
B4603_RS07135	COG0488	(ABC) transporter
B4603_RS07140	COG0527	aspartate kinase activity
B4603_RS07145	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B4603_RS07180	COG2808	Putative FMN-binding domain
B4603_RS07225	COG4548	von Willebrand factor, type A
B4603_RS07230	COG0714	Associated with various cellular activities
B4603_RS07275	COG0671	phosphoesterase, PA-phosphatase related
B4603_RS07350	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
B4603_RS07370	COG0531	amino acid
B4603_RS07385	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4603_RS07390	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
B4603_RS07405	COG0116	Belongs to the methyltransferase superfamily
B4603_RS07435	COG4499	WXG100 protein secretion system (Wss), protein YukC
B4603_RS07435	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B4603_RS07445	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B4603_RS07450	COG3935	DnaD domain protein
B4603_RS07475	COG0438	transferase activity, transferring glycosyl groups
B4603_RS07480	COG1694	Mazg nucleotide pyrophosphohydrolase
B4603_RS07485	COG2738	Putative neutral zinc metallopeptidase
B4603_RS07490	COG4347	Protein of unknown function (DUF1405)
B4603_RS07530	COG0142	geranyltranstransferase activity
B4603_RS07595	COG0492	ferredoxin-NADP+ reductase activity
B4603_RS07610	COG0514	ATP-dependent DNA helicase (RecQ)
B4603_RS07620	COG1141	Ferredoxin
B4603_RS07680	COG5632	N-Acetylmuramoyl-L-alanine amidase
B4603_RS07680	COG1388	LysM domain
B4603_RS07730	COG5280	Phage tail tape measure protein TP901
B4603_RS07730	COG3953	SLT domain
B4603_RS07965	COG3646	Phage regulatory protein
B4603_RS07965	COG3645	SOS response
B4603_RS08000	COG0582	viral genome integration into host DNA
B4603_RS08015	COG5002	protein histidine kinase activity
B4603_RS08020	COG0745	RESPONSE REGULATOR receiver
B4603_RS08025	COG1187	pseudouridine synthase activity
B4603_RS08050	COG0735	belongs to the Fur family
B4603_RS08055	COG0494	nUDIX hydrolase
B4603_RS08060	COG0667	Aldo Keto reductase
B4603_RS08085	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B4603_RS08095	COG0366	Alpha amylase catalytic
B4603_RS08100	COG1609	Transcriptional regulator
B4603_RS08120	COG2195	Cleaves the N-terminal amino acid of tripeptides
B4603_RS08130	COG4129	membrane
B4603_RS08140	COG0508	dehydrogenase complex catalyzes the overall conversion of
B4603_RS08145	COG0022	dehydrogenase e1 component
B4603_RS08150	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B4603_RS08155	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B4603_RS08160	COG0497	DNA recombination
B4603_RS08190	COG1302	Protein conserved in bacteria
B4603_RS08195	COG0439	Biotin carboxylase
B4603_RS08200	COG0511	ligase activity, forming carbon-carbon bonds
B4603_RS08210	COG0006	proline dipeptidase activity
B4603_RS08225	COG0095	Lipoate-protein ligase
B4603_RS08230	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B4603_RS08275	COG4537	Required for transformation and DNA binding
B4603_RS08280	COG1459	type II secretion system
B4603_RS08285	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B4603_RS08290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4603_RS08295	COG0011	TIGRFAM Protein of
B4603_RS08300	COG1940	carbohydrate kinase activity
B4603_RS08305	COG4483	Protein conserved in bacteria
B4603_RS08315	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B4603_RS08325	COG0768	penicillin binding
B4603_RS08340	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B4603_RS08345	COG1121	(ABC) transporter
B4603_RS08355	COG0513	Belongs to the DEAD box helicase family
B4603_RS08365	COG2384	SAM-dependent methyltransferase
B4603_RS08385	COG0517	IMP dehydrogenase activity
B4603_RS08405	COG0295	cytidine deaminase activity
B4603_RS08420	COG1702	phosphate starvation-inducible protein PhoH
B4603_RS08435	COG1030	water channel activity
B4603_RS08445	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B4603_RS08450	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B4603_RS08480	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B4603_RS08500	COG1466	dna polymerase III delta subunit
B4603_RS08505	COG0658	competence protein
B4603_RS08505	COG2333	competence protein COMEC
B4603_RS08510	COG2131	deaminase
B4603_RS08520	COG2226	methyltransferase
B4603_RS08525	COG0799	negative regulation of ribosome biogenesis
B4603_RS08530	COG1713	HD superfamily hydrolase involved in NAD metabolism
B4603_RS08540	COG1534	Rna-binding protein
B4603_RS08550	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B4603_RS08555	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
B4603_RS08575	COG3177	Filamentation induced by cAMP protein fic
B4603_RS08580	COG1914	H( )-stimulated, divalent metal cation uptake system
B4603_RS08590	COG0439	Biotin carboxylase
B4603_RS08595	COG0511	ligase activity, forming carbon-carbon bonds
B4603_RS08600	COG1984	allophanate hydrolase subunit 2
B4603_RS08605	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
B4603_RS08620	COG0826	peptidase U32
B4603_RS08625	COG0826	peptidase U32
B4603_RS08655	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B4603_RS08680	COG1104	cysteine desulfurase activity
B4603_RS08685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4603_RS08695	COG3237	CsbD-like
B4603_RS08700	COG1959	2 iron, 2 sulfur cluster binding
B4603_RS08705	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B4603_RS08710	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B4603_RS08755	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
B4603_RS08755	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B4603_RS08760	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B4603_RS08760	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B4603_RS08765	COG1862	Preprotein translocase
B4603_RS08805	COG2868	ribosomal protein
B4603_RS08850	COG0488	(ABC) transporter
B4603_RS08875	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
B4603_RS08885	COG0285	dihydrofolate synthase activity
B4603_RS08895	COG2818	Glycosylase
B4603_RS08930	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B4603_RS08965	COG4112	unkown
B4603_RS08990	COG0833	amino acid
B4603_RS09005	COG1484	DNA-dependent DNA replication
B4603_RS09035	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4603_RS09035	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4603_RS09045	COG5002	protein histidine kinase activity
B4603_RS09050	COG0745	RESPONSE REGULATOR receiver
B4603_RS09065	COG0372	Belongs to the citrate synthase family
B4603_RS09070	COG1113	amino acid transport
B4603_RS09095	COG0281	malic enzyme
B4603_RS09105	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
B4603_RS09120	COG4109	DRTGG domain
B4603_RS09165	COG0827	DNA restriction-modification system
B4603_RS09175	COG0730	response to heat
B4603_RS09185	COG1104	cysteine desulfurase activity
B4603_RS09195	COG1956	GAF domain-containing protein
B4603_RS09210	COG0584	glycerophosphoryl diester phosphodiesterase
B4603_RS09215	COG1764	response to oxidative stress
B4603_RS09220	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B4603_RS09225	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B4603_RS09240	COG1263	PTS System
B4603_RS09240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4603_RS09245	COG0204	Acyl-transferase
B4603_RS09250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B4603_RS09270	COG5386	Cell surface protein
B4603_RS09285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B4603_RS09290	COG0454	-acetyltransferase
B4603_RS09310	COG1605	Chorismate mutase
B4603_RS09310	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
B4603_RS09335	COG1674	ftsk spoiiie
B4603_RS09340	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B4603_RS09350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4603_RS09355	COG1363	Peptidase, m42
B4603_RS09365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4603_RS09375	COG0510	thiamine kinase activity
B4603_RS09395	COG1187	pseudouridine synthase activity
B4603_RS09400	COG2244	polysaccharide biosynthetic process
B4603_RS09405	COG2081	HI0933 family
B4603_RS09425	COG2814	Major facilitator Superfamily
B4603_RS09430	COG1242	4 iron, 4 sulfur cluster binding
B4603_RS09435	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
B4603_RS09445	COG2267	carboxylic ester hydrolase activity
B4603_RS09480	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B4603_RS09480	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B4603_RS09500	COG3266	domain, Protein
B4603_RS09500	COG4193	domain, Protein
B4603_RS09500	COG5632	N-Acetylmuramoyl-L-alanine amidase
B4603_RS09535	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B4603_RS09555	COG0656	L-ascorbic acid biosynthetic process
B4603_RS09575	COG1506	peptidase
B4603_RS09580	COG2816	NAD+ diphosphatase activity
B4603_RS09670	COG5492	domain, Protein
B4603_RS09770	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
B4603_RS09800	COG1131	(ABC) transporter
B4603_RS09805	COG0537	adenosine 5'-monophosphoramidase activity
B4603_RS09835	COG0420	3'-5' exonuclease activity
B4603_RS09865	COG2197	response regulator
B4603_RS09870	COG4585	Histidine kinase
B4603_RS09870	COG2203	Gaf domain
B4603_RS09875	COG0564	pseudouridine synthase activity
B4603_RS09910	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B4603_RS09915	COG1126	abc transporter atp-binding protein
B4603_RS09920	COG0765	amino acid transport
B4603_RS10085	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B4603_RS10090	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B4603_RS10100	COG4129	membrane
B4603_RS10120	COG1194	a g-specific adenine glycosylase
B4603_RS10125	COG1988	membrane-bound metal-dependent
B4603_RS10140	COG1388	LysM domain
B4603_RS10140	COG1134	teichoic acid transport
B4603_RS10170	COG0535	radical SAM domain protein
B4603_RS10175	COG1607	acyl-coa hydrolase
B4603_RS10180	COG2309	aminopeptidase activity
B4603_RS10200	COG1295	ribonuclease BN
B4603_RS10325	COG4851	CamS sex pheromone cAM373 precursor
B4603_RS10345	COG4496	protein, YerC YecD
B4603_RS10380	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B4603_RS10390	COG0077	Prephenate dehydratase
B4603_RS10410	COG1335	isochorismatase
B4603_RS10425	COG1012	belongs to the aldehyde dehydrogenase family
B4603_RS10435	COG3682	Transcriptional regulator
B4603_RS10465	COG4974	Belongs to the 'phage' integrase family
B4603_RS10515	COG1131	(ABC) transporter
B4603_RS10530	COG1725	Transcriptional regulator
B4603_RS10580	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B4603_RS10660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B4603_RS10665	COG1621	beta-fructofuranosidase activity
B4603_RS10670	COG1609	Transcriptional regulator
B4603_RS10680	COG0425	Belongs to the sulfur carrier protein TusA family
B4603_RS10685	COG2391	methyltransferase activity
B4603_RS10695	COG0488	(ABC) transporter
B4603_RS10705	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B4603_RS10715	COG0456	acetyltransferase
B4603_RS10720	COG1214	PFAM Peptidase M22, glycoprotease
B4603_RS10725	COG0802	atpase or kinase
B4603_RS10740	COG0028	Belongs to the TPP enzyme family
B4603_RS10815	COG2183	response to ionizing radiation
B4603_RS10820	COG1191	sigma factor activity
B4603_RS10830	COG1366	Belongs to the anti-sigma-factor antagonist family
B4603_RS10835	COG2208	phosphoserine phosphatase activity
B4603_RS10870	COG3428	Bacterial PH domain
B4603_RS10900	COG2205	protein histidine kinase activity
B4603_RS10905	COG0745	RESPONSE REGULATOR receiver
B4603_RS10915	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B4603_RS10925	COG0772	Belongs to the SEDS family
B4603_RS10940	COG1937	Protein conserved in bacteria
B4603_RS10950	COG1418	mRNA catabolic process
B4603_RS11000	COG0629	single-stranded DNA binding
B4603_RS11080	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B4603_RS11105	COG0009	L-threonylcarbamoyladenylate synthase
B4603_RS11110	COG2890	protein-(glutamine-N5) methyltransferase activity
B4603_RS11135	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B4603_RS11175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4603_RS11225	COG0813	purine-nucleoside phosphorylase activity
B4603_RS11230	COG0783	Belongs to the Dps family
B4603_RS11250	COG1482	cell wall glycoprotein biosynthetic process
B4603_RS11255	COG0702	epimerase
B4603_RS11260	COG0640	Transcriptional regulator
B4603_RS11295	COG0561	phosphatase activity
B4603_RS11300	COG1119	ATPase activity
B4603_RS11320	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
B4603_RS11385	COG3711	transcriptional antiterminator
B4603_RS11415	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
B4603_RS11475	COG0489	protein tyrosine kinase activity
B4603_RS11480	COG2814	Major facilitator Superfamily
B4603_RS11495	COG1272	protein, Hemolysin III
B4603_RS11505	COG1988	membrane-bound metal-dependent
B4603_RS11515	COG3314	Sporulation integral membrane protein YlbJ
B4603_RS11520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4603_RS11525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4603_RS11530	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
B4603_RS11540	COG3457	Alanine racemase
B4603_RS11545	COG4264	IucA IucC family
B4603_RS11550	COG2814	Major facilitator Superfamily
B4603_RS11575	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B4603_RS11585	COG2130	NADP-dependent
B4603_RS11650	COG0656	L-ascorbic acid biosynthetic process
B4603_RS11655	COG0789	Transcriptional regulator
B4603_RS11665	COG5492	domain, Protein
B4603_RS11680	COG0438	transferase activity, transferring glycosyl groups
B4603_RS11695	COG3527	Alpha-acetolactate decarboxylase
B4603_RS11700	COG0028	Belongs to the TPP enzyme family
B4603_RS11710	COG2826	transposase and inactivated derivatives, IS30 family
B4603_RS11785	COG0201	protein transport
B4603_RS11900	COG2252	PERMEase
B4603_RS11945	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B4603_RS12020	COG1763	Mo-molybdopterin cofactor biosynthetic process
B4603_RS12040	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B4603_RS12045	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
B4603_RS12050	COG4149	molybdate abc transporter
B4603_RS12055	COG0725	ABC transporter, periplasmic molybdate-binding protein
B4603_RS12070	COG1268	BioY protein
B4603_RS12085	COG1960	acyl-CoA dehydrogenase activity
B4603_RS12090	COG4413	Urea transporter
B4603_RS12165	COG1757	Na H antiporter
B4603_RS12180	COG3942	CHAP domain
B4603_RS12250	COG1266	CAAX protease self-immunity
B4603_RS12265	COG1113	amino acid transport
B4603_RS12285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B4603_RS12290	COG0385	Bile acid
B4603_RS12300	COG1263	PTS System
B4603_RS12300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4603_RS12305	COG1737	Transcriptional regulator
B4603_RS12325	COG1028	Short-chain dehydrogenase reductase Sdr
B4603_RS12330	COG1473	amidohydrolase
B4603_RS12345	COG0583	DNA-binding transcription factor activity
B4603_RS12365	COG2258	MOSC domain
B4603_RS12385	COG1668	transmembrane transport
B4603_RS12390	COG4152	abc transporter atp-binding protein
B4603_RS12395	COG3152	Membrane
B4603_RS12410	COG0786	glutamate:sodium symporter activity
B4603_RS12420	COG0598	Magnesium transport protein CorA
B4603_RS12435	COG0657	acetylesterase activity
B4603_RS12445	COG2814	Major facilitator Superfamily
B4603_RS12450	COG1566	PFAM secretion protein HlyD family protein
B4603_RS12465	COG2814	Major facilitator Superfamily
B4603_RS12530	COG1620	l-lactate permease
B4603_RS12540	COG2826	transposase and inactivated derivatives, IS30 family
B4603_RS12555	COG0604	alcohol dehydrogenase
B4603_RS12585	COG1511	domain protein
B4603_RS12600	COG1263	PTS System
B4603_RS12600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4603_RS12615	COG3871	stress protein (general stress protein 26)
B4603_RS12665	COG0789	Transcriptional regulator
B4603_RS12685	COG2181	nitrate reductase activity
B4603_RS12695	COG1140	nitrate reductase beta subunit
B4603_RS12700	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
B4603_RS12710	COG2146	nitrite reductase [NAD(P)H] activity
B4603_RS12715	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B4603_RS12725	COG0454	-acetyltransferase
B4603_RS12735	COG2116	formate transmembrane transporter activity
B4603_RS12750	COG0803	Belongs to the bacterial solute-binding protein 9 family
B4603_RS12750	COG3443	Belongs to the bacterial solute-binding protein 9 family
B4603_RS12775	COG1126	abc transporter atp-binding protein
B4603_RS12780	COG0765	amino acid transport
B4603_RS12785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4603_RS12790	COG2814	Major facilitator Superfamily
B4603_RS12810	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B4603_RS12860	COG0156	8-amino-7-oxononanoate synthase activity
B4603_RS12870	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B4603_RS12875	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
B4603_RS12890	COG1132	(ABC) transporter
B4603_RS12895	COG2375	cellular response to nickel ion
B4603_RS12895	COG1132	(ABC) transporter
B4603_RS12915	COG1929	Belongs to the glycerate kinase type-1 family
B4603_RS12925	COG2814	Major facilitator Superfamily
B4603_RS12945	COG1113	amino acid transport
B4603_RS12955	COG0531	amino acid
B4603_RS12975	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B4603_RS12985	COG1174	glycine betaine transport
B4603_RS12995	COG1174	glycine betaine transport
B4603_RS13010	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
B4603_RS13015	COG0531	amino acid
B4603_RS13020	COG2272	Belongs to the type-B carboxylesterase lipase family
B4603_RS13025	COG2814	Major facilitator Superfamily
B4603_RS13030	COG0390	transport system, permease component
B4603_RS13035	COG4619	ABC transporter
B4603_RS13040	COG1363	Peptidase, m42
B4603_RS13045	COG4808	Protein conserved in bacteria
B4603_RS13050	COG0069	glutamate synthase activity
B4603_RS13065	COG1124	(ABC) transporter
B4603_RS13075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B4603_RS13080	COG0601	transmembrane transport
B4603_RS13085	COG0747	negative chemotaxis
B4603_RS13115	COG1028	Short-chain dehydrogenase reductase Sdr
B4603_RS13120	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
B4603_RS13125	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B4603_RS13275	COG1070	Carbohydrate kinase
B4603_RS13280	COG1802	Transcriptional regulator
B4603_RS13285	COG0789	Transcriptional regulator
B4603_RS13290	COG2357	RelA SpoT domain protein
B4603_RS13295	COG4876	unkown
B4603_RS13310	COG2271	Major facilitator Superfamily
B4603_RS13315	COG0586	Pfam SNARE associated Golgi protein
B4603_RS13325	COG2814	Major facilitator Superfamily
B4603_RS13330	COG1846	Transcriptional regulator
B4603_RS13340	COG1131	(ABC) transporter
B4603_RS13360	COG0400	carboxylic ester hydrolase activity
B4603_RS13365	COG0346	lactoylglutathione lyase activity
B4603_RS13370	COG1846	Transcriptional regulator
B4603_RS13380	COG2514	catechol 2,3-dioxygenase activity
B4603_RS13395	COG0561	phosphatase activity
B4603_RS13400	COG3764	Sortase (surface protein transpeptidase)
B4603_RS13420	COG1760	l-serine dehydratase
B4603_RS13425	COG1760	l-serine dehydratase
B4603_RS13440	COG0697	spore germination
B4603_RS13445	COG0657	acetylesterase activity
B4603_RS13465	COG0028	Belongs to the TPP enzyme family
B4603_RS13480	COG0583	DNA-binding transcription factor activity
B4603_RS13490	COG3942	CHAP domain
B4603_RS13500	COG3425	synthase
B4603_RS13505	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B4603_RS13530	COG2409	Drug exporters of the RND superfamily
B4603_RS13575	COG0436	Aminotransferase
B4603_RS13680	COG0596	Alpha beta hydrolase
B4603_RS13720	COG3001	Fructosamine kinase
B4603_RS13725	COG0167	dihydroorotate dehydrogenase activity
B4603_RS13775	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B4603_RS13780	COG3527	Alpha-acetolactate decarboxylase
B4603_RS13795	COG0531	amino acid
B4603_RS13825	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B4603_RS13845	COG1012	belongs to the aldehyde dehydrogenase family
B4603_RS13855	COG1510	regulation of RNA biosynthetic process
B4603_RS13860	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B4603_RS13885	COG2851	Citrate transporter
B4603_RS13900	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B4603_RS13910	COG0386	Belongs to the glutathione peroxidase family
B4603_RS13935	COG1136	(ABC) transporter
B4603_RS13940	COG2205	protein histidine kinase activity
B4603_RS13945	COG0745	RESPONSE REGULATOR receiver
B4603_RS13955	COG1785	Belongs to the alkaline phosphatase family
B4603_RS13965	COG1846	Transcriptional regulator
B4603_RS14010	COG1438	arginine binding
B4603_RS14030	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4603_RS14030	COG3711	transcriptional antiterminator
B4603_RS14035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4603_RS14035	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B4603_RS14035	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B4603_RS14040	COG1482	cell wall glycoprotein biosynthetic process
B4603_RS14050	COG3942	CHAP domain
B4603_RS14050	COG1705	Flagellar rod assembly protein muramidase FlgJ
B4603_RS14055	COG1535	isochorismatase
B4603_RS14055	COG3433	isochorismatase activity
B4603_RS14070	COG0438	transferase activity, transferring glycosyl groups
B4603_RS14085	COG1073	alpha beta
B4603_RS14105	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B4603_RS14135	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B4603_RS14230	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B4603_RS14300	COG0471	metal ion transport
B4603_RS14310	COG2962	Rard protein
B4603_RS14320	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
B4603_RS14335	COG1136	(ABC) transporter
B4603_RS14340	COG0577	efflux transmembrane transporter activity
B4603_RS14350	COG1278	Cold shock
B4603_RS14370	COG1475	DNA binding