locus-tag class description HZR12_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HZR12_RS00015 ENOG410848D S4 domain protein YaaA HZR12_RS00025 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HZR12_RS00035 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HZR12_RS00060 ENOG4105DWV Homoserine O-trans-acetylase HZR12_RS00070 ENOG4105BZR domain protein HZR12_RS00080 ENOG4105CDU Replicative dna helicase HZR12_RS00085 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HZR12_RS00120 ENOG4105Q2H domain protein HZR12_RS00150 ENOG4105C2M dna polymerase I HZR12_RS00185 ENOG4108BUD transposase HZR12_RS00195 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HZR12_RS00200 ENOG4108ZMQ domain protein HZR12_RS00205 ENOG4107RVG penicillin-binding protein HZR12_RS00250 ENOG4107Y5K Resolvase HZR12_RS00290 ENOG4105WKZ CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) HZR12_RS00295 ENOG410695F Crispr-associated protein, Csm1 family HZR12_RS00300 ENOG4105W69 CRISPR-Associated Protein HZR12_RS00305 ENOG4108W8W CRISPR-associated RAMP protein, Csm3 family HZR12_RS00310 ENOG4108T47 CRISPR-associated RAMP protein, Csm4 family HZR12_RS00315 ENOG4105G15 CRISPR-associated RAMP protein, Csm5 family HZR12_RS00320 ENOG4108QA2 CRISPR-associated protein, Csm6 HZR12_RS00325 ENOG4105GIM CRISPR-associated protein cas6 HZR12_RS00340 ENOG4105D85 methylase HZR12_RS00350 ENOG4105DQ6 Transposase HZR12_RS00355 ENOG4108UXE Protein tyrosine phosphatase HZR12_RS00380 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HZR12_RS00385 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HZR12_RS00390 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HZR12_RS00415 ENOG4108UXE Protein tyrosine phosphatase HZR12_RS00445 ENOG41085FC arsR family transcriptional regulator HZR12_RS00460 ENOG4105DQ4 alcohol dehydrogenase HZR12_RS00520 ENOG4108WS4 fmn reductase HZR12_RS00535 ENOG4105ENX hydrolase HZR12_RS00555 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C HZR12_RS00585 ENOG4105C57 major facilitator superfamily HZR12_RS00595 ENOG4105CCI Myosin-Cross-Reactive Antigen HZR12_RS00620 ENOG4106I9N Immunoglobulin G binding protein A HZR12_RS00630 ENOG4108IHU transport system permease protein HZR12_RS00635 ENOG4105DQ5 transport system permease protein HZR12_RS00640 ENOG4108MES Periplasmic binding protein HZR12_RS00650 ENOG4105CIF Ornithine Cyclodeaminase HZR12_RS00655 ENOG4105DJU Siderophore biosynthesis protein HZR12_RS00660 ENOG4105C6X Major Facilitator HZR12_RS00665 ENOG4105DBM Siderophore biosynthesis protein HZR12_RS00670 ENOG4105DUU IucA IucC family protein HZR12_RS00680 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HZR12_RS00685 ENOG41067FT ParB-like nuclease domain HZR12_RS00695 ENOG4105CHR reductase HZR12_RS00705 ENOG4108IAJ Nad-dependent epimerase dehydratase HZR12_RS00715 ENOG4105CPK Glycosyl transferase (Group 1 HZR12_RS00730 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HZR12_RS00750 ENOG4108J8C transporter major facilitator family protein HZR12_RS00755 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) HZR12_RS00790 ENOG4105CGH 5'-nucleotidase HZR12_RS00805 ENOG4108RS6 transposase HZR12_RS00810 ENOG4108RS6 transposase HZR12_RS00815 ENOG4105C0A alcohol dehydrogenase HZR12_RS00840 ENOG4105C5E polysaccharide biosynthesis protein HZR12_RS00850 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HZR12_RS00880 ENOG4105D3Q Sugar transferase HZR12_RS00895 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HZR12_RS00905 ENOG4105WD1 Membrane HZR12_RS00915 ENOG4105PGM cation diffusion facilitator family transporter HZR12_RS00945 ENOG4105C1G acyl-Coa dehydrogenase HZR12_RS00950 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) HZR12_RS00980 ENOG4108BUD transposase HZR12_RS00990 ENOG4105DQ6 Transposase HZR12_RS01000 ENOG4105G6Z alkaline phosphatase HZR12_RS01050 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HZR12_RS01055 ENOG4108Z73 Siroheme synthase HZR12_RS01065 ENOG4105D4T Citrate transporter HZR12_RS01070 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HZR12_RS01075 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HZR12_RS01090 ENOG4105C94 Transporter HZR12_RS01100 ENOG4105TRT Transcriptional regulator HZR12_RS01130 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HZR12_RS01140 ENOG4105DWT malate dehydrogenase (quinone) HZR12_RS01155 ENOG4108JPW Aminotransferase HZR12_RS01160 ENOG4105CUB amino acid HZR12_RS01170 ENOG4107FQX Alpha-acetolactate decarboxylase HZR12_RS01175 ENOG4108NKJ Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HZR12_RS01185 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HZR12_RS01225 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) HZR12_RS01250 ENOG4107T5J pyridine nucleotide-disulfide oxidoreductase HZR12_RS01265 ENOG4108SXP alpha beta HZR12_RS01275 ENOG4105CHR reductase HZR12_RS01300 ENOG4105VPS UPF0291 protein HZR12_RS01330 ENOG4105DQ6 Transposase HZR12_RS01345 ENOG4105EXC Acyl-transferase HZR12_RS01350 ENOG41068JE domain protein HZR12_RS01405 ENOG4108UW5 maltose o-acetyltransferase HZR12_RS01425 ENOG4105EYF MMPL domain protein HZR12_RS01435 ENOG4105CE1 Ferrous iron transport protein b HZR12_RS01450 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HZR12_RS01455 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase HZR12_RS01480 ENOG41068JE domain protein HZR12_RS01490 ENOG4105CMU LysR family (Transcriptional regulator HZR12_RS01500 ENOG41067MG lrgb family HZR12_RS01530 ENOG4108UZ3 Transporter HZR12_RS01550 ENOG4105EJQ L-serine dehydratase HZR12_RS01565 ENOG4108Z7F N-acetyltransferase HZR12_RS01570 ENOG4108Z6X (sortase) family HZR12_RS01575 ENOG4106KKU HZR12_RS01580 ENOG4108Z15 abc transporter atp-binding protein HZR12_RS01585 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) HZR12_RS01590 ENOG4105C5I Dehydrogenase HZR12_RS01600 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase HZR12_RS01610 ENOG41090MY MarR family Transcriptional regulator HZR12_RS01620 ENOG4105FBA Phospholipase Carboxylesterase HZR12_RS01625 ENOG4108K88 Membrane HZR12_RS01640 ENOG4105CJ1 ABC, transporter HZR12_RS01660 ENOG4107T5V SNARE associated Golgi HZR12_RS01665 ENOG4105DJB Major Facilitator Superfamily HZR12_RS01675 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) HZR12_RS01690 ENOG4105G3Z GntR family transcriptional regulator HZR12_RS01695 ENOG4105CMG Carbohydrate kinase HZR12_RS01710 ENOG41078HS Fibronectin binding protein B HZR12_RS01720 ENOG4105DQ6 Transposase HZR12_RS01775 ENOG4105M6F mutator MutT protein HZR12_RS01860 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HZR12_RS01865 ENOG4105CFC Transporter HZR12_RS01895 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HZR12_RS01900 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HZR12_RS01905 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HZR12_RS01910 ENOG4108RZA ABC transporter HZR12_RS01915 ENOG4108S9F abc transporter, atp-binding protein HZR12_RS01930 ENOG4105CBC glutamate synthase HZR12_RS01935 ENOG4105PQ4 (LipO)protein HZR12_RS01950 ENOG4105CN9 Peptidase m42 family protein HZR12_RS01955 ENOG41083J0 (ABC) transporter HZR12_RS01960 ENOG4105C4B ABC transporter, permease HZR12_RS01965 ENOG4105F27 Major Facilitator HZR12_RS01970 ENOG4105EBR Carboxylesterase HZR12_RS01975 ENOG4107QTZ amino acid HZR12_RS01980 ENOG4105CZ9 Domain of unknown function (DU1801) HZR12_RS02000 ENOG4105E90 ABC transporter HZR12_RS02010 ENOG4105R40 Glycine betaine carnitine choline HZR12_RS02015 ENOG4105C57 major facilitator superfamily HZR12_RS02020 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HZR12_RS02030 ENOG4105ED2 Beta-lactamase HZR12_RS02035 ENOG4105C0X amino acid HZR12_RS02040 ENOG4105EEQ Na H antiporter HZR12_RS02045 ENOG4105C85 amino acid HZR12_RS02065 ENOG4105C2C drug resistance transporter, Bcr CflA HZR12_RS02075 ENOG4105BZW Glycerate kinase HZR12_RS02095 ENOG4105BZ1 (ABC) transporter HZR12_RS02105 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HZR12_RS02110 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HZR12_RS02120 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HZR12_RS02180 ENOG4105EAB amino acid AbC transporter HZR12_RS02185 ENOG4105DRP amino acid AbC transporter HZR12_RS02190 ENOG4105CDA abc transporter atp-binding protein HZR12_RS02205 ENOG4108BUD transposase HZR12_RS02215 ENOG4108BUD transposase HZR12_RS02250 ENOG4105DSE periplasmic solute binding protein HZR12_RS02265 ENOG4105TMB Formate nitrite transporter HZR12_RS02270 ENOG4108XSB acetyltransferase, (GNAT) family HZR12_RS02280 ENOG4108IFG nitrite reductase, (NAD(P)H) HZR12_RS02285 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit HZR12_RS02290 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HZR12_RS02300 ENOG4108IUE nitrate reductase beta subunit HZR12_RS02330 ENOG4107TXC Transcriptional regulator HZR12_RS02370 ENOG410606W general stress protein HZR12_RS02400 ENOG4105ECB domain protein HZR12_RS02420 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HZR12_RS02450 ENOG4105DWT malate dehydrogenase (quinone) HZR12_RS02520 ENOG4105CW7 secretion protein, HlyD family HZR12_RS02525 ENOG4105C0R drug resistance transporter emrb qaca subfamily HZR12_RS02550 ENOG4105D7N magnesium and cobalt transport protein CorA HZR12_RS02560 ENOG4105D6U Sodium Glutamate Symporter HZR12_RS02575 ENOG4108IUX (ABC) transporter HZR12_RS02580 ENOG4105RHA ABC transporter, permease HZR12_RS02600 ENOG4108RPX mosc domain containing protein HZR12_RS02605 ENOG4105E66 phosphoriboisomerase A HZR12_RS02640 ENOG4105CH2 amidohydrolase HZR12_RS02645 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HZR12_RS02665 ENOG4108Q3X Transcriptional regulator HZR12_RS02670 ENOG4105CI1 PTS System HZR12_RS02680 ENOG4105C09 Bile acid HZR12_RS02685 ENOG4107YBY Hydrolase HZR12_RS02760 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis HZR12_RS02790 ENOG4105DFD Na H antiporter HZR12_RS02800 ENOG41068JE domain protein HZR12_RS02865 ENOG4105FDT acyl-CoA dehydrogenase HZR12_RS02880 ENOG4107ZYJ bioY protein HZR12_RS02895 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HZR12_RS02900 ENOG4105E0C molybdate abc transporter HZR12_RS02905 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) HZR12_RS02910 ENOG4105D06 uba thif-type nad fad binding protein HZR12_RS02915 ENOG4105EPU Molybdenum cofactor synthesis domain protein HZR12_RS02925 ENOG4105CVM Molybdenum cofactor synthesis domain protein HZR12_RS02930 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein HZR12_RS02935 ENOG4108ZAF Molybdopterin HZR12_RS02970 ENOG41065XD Transcriptional regulator HZR12_RS03015 ENOG4105CSC Glucose uptake protein HZR12_RS03035 ENOG4105C7N Xanthine uracil vitamin C permease HZR12_RS03150 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HZR12_RS03155 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HZR12_RS03235 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HZR12_RS03260 ENOG4107FQX Alpha-acetolactate decarboxylase HZR12_RS03280 ENOG4106AM8 polysaccharide lyase family 8 HZR12_RS03315 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HZR12_RS03345 ENOG4105VCP PTS System HZR12_RS03350 ENOG4105CK1 PTS System HZR12_RS03365 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HZR12_RS03370 ENOG4105CIS alcohol dehydrogenase HZR12_RS03375 ENOG4105C94 Transporter HZR12_RS03390 ENOG4105VBF alkaline shock protein HZR12_RS03405 ENOG4107SFI Major Facilitator superfamily HZR12_RS03415 ENOG4106M28 alanine racemase domain protein HZR12_RS03425 ENOG4108HUF Transporter HZR12_RS03430 ENOG4105DQ5 transport system permease protein HZR12_RS03435 ENOG4108U1V ABC transporter, permease HZR12_RS03440 ENOG4105DWD nucleoside recognition domain protein HZR12_RS03450 ENOG4107K5X Membrane-bound metal-dependent hydrolase HZR12_RS03460 ENOG4108UT2 hemolysin iii HZR12_RS03480 ENOG4105D1F ATP-binding protein HZR12_RS03550 ENOG4105CYW agmatinase HZR12_RS03555 ENOG4105C8B TIGR00159 family HZR12_RS03575 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase HZR12_RS03580 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HZR12_RS03585 ENOG4105ETD TRANSCRIPTIONal HZR12_RS03595 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HZR12_RS03600 ENOG4105DKW ABC transporter HZR12_RS03635 ENOG4105PGM cation diffusion facilitator family transporter HZR12_RS03650 ENOG4105DG6 mannose-6-phosphate isomerase HZR12_RS03670 ENOG4108RMU ferritin dps family protein HZR12_RS03675 ENOG4105D3A purine nucleoside phosphorylase DeoD-type HZR12_RS03680 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) HZR12_RS03730 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HZR12_RS03740 ENOG4105D2N Aldolase HZR12_RS03745 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HZR12_RS03760 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HZR12_RS03780 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HZR12_RS03785 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HZR12_RS03790 ENOG4107WAU Protein tyrosine phosphatase HZR12_RS03810 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HZR12_RS03900 ENOG4105DWF phosphomethylpyrimidine kinase HZR12_RS03925 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HZR12_RS03930 ENOG4105VPX protein, conserved in bacteria HZR12_RS03955 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) HZR12_RS03965 ENOG4105DQ6 Transposase HZR12_RS04010 ENOG4105CKV Membrane HZR12_RS04040 ENOG4107SGM protein serine threonine phosphatase HZR12_RS04045 ENOG4105WN5 stage II sporulation protein HZR12_RS04110 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HZR12_RS04130 ENOG4105C7K acetolactate synthase HZR12_RS04145 ENOG4105K8N protein family UPF0079, ATPase HZR12_RS04150 ENOG41072GX Peptidase M22 Glycoprotease HZR12_RS04155 ENOG410801F ribosomal-protein-alanine acetyltransferase HZR12_RS04165 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) HZR12_RS04175 ENOG4105C5H ABC transporter HZR12_RS04185 ENOG4105CUC YeeE YedE family protein HZR12_RS04195 ENOG4105BZU Histidine kinase HZR12_RS04245 ENOG4105DQ6 Transposase HZR12_RS04255 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HZR12_RS04285 ENOG4105VTR Integrase HZR12_RS04365 ENOG4108TFU terminase (Small subunit) HZR12_RS04395 ENOG4105CZN Potassium uptake protein HZR12_RS04410 ENOG4105DQ6 Transposase HZR12_RS04435 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) HZR12_RS04465 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HZR12_RS04480 ENOG4105CJ1 ABC, transporter HZR12_RS04535 ENOG4105C26 Dehydrogenase HZR12_RS04560 ENOG4105C8P )-transporter HZR12_RS04570 ENOG4105CQC Prephenate dehydratase HZR12_RS04575 ENOG4107QN4 Catalyzes the production of nitric oxide (By similarity) HZR12_RS04580 ENOG4105DAP Nicotinate phosphoribosyltransferase HZR12_RS04605 ENOG4107DDB Cysteine protease able to HZR12_RS04615 ENOG4105KGF protein, YerC YecD HZR12_RS04625 ENOG4105C4R Atp-dependent dna helicase HZR12_RS04670 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HZR12_RS04725 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HZR12_RS04740 ENOG4105ENE Histidine kinase HZR12_RS04750 ENOG4107U9T Pfam:Ribonuclease_BN HZR12_RS04775 ENOG4108S4H thioesterase Superfamily protein HZR12_RS04790 ENOG4108Z0Z intracellular protease Pfpi family HZR12_RS04810 ENOG4105EY8 ABC transporter HZR12_RS04820 ENOG41067AE Membrane-bound metal-dependent hydrolase HZR12_RS04845 ENOG4107NBY Membrane HZR12_RS04855 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HZR12_RS04860 ENOG4108M3J Dehydrogenase HZR12_RS05035 ENOG4105E5Q amino acid AbC transporter HZR12_RS05040 ENOG4105CDA abc transporter atp-binding protein HZR12_RS05045 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HZR12_RS05070 ENOG4105C9Q fumarate hydratase class II HZR12_RS05075 ENOG4108YBP pseudouridine synthase HZR12_RS05080 ENOG4105BZU Histidine kinase HZR12_RS05085 ENOG4105WH1 Two component transcriptional regulator luxr family HZR12_RS05110 ENOG4107VRP DNA repair exonuclease HZR12_RS05140 ENOG4105K59 histidine triad (HIT) protein HZR12_RS05170 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HZR12_RS05175 ENOG4105C1Q protoporphyrinogen oxidase HZR12_RS05245 ENOG4105DQ6 Transposase HZR12_RS05275 ENOG4108BUD transposase HZR12_RS05300 ENOG4108BUD transposase HZR12_RS05310 ENOG4105DQ6 Transposase HZR12_RS05355 ENOG4108BUD transposase HZR12_RS05370 ENOG4105HMI Membrane HZR12_RS05385 ENOG4105DQ6 Transposase HZR12_RS05490 ENOG4108RS6 transposase HZR12_RS05510 ENOG4105CV8 reductase HZR12_RS05525 ENOG4105WMR Protein CrcB homolog HZR12_RS05535 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HZR12_RS05555 ENOG4106FBB RNA Polymerase HZR12_RS05565 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis HZR12_RS05575 ENOG4107R3E Citrate transporter HZR12_RS05590 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HZR12_RS05595 ENOG4108R6K riboflavin synthase, subunit alpha HZR12_RS05600 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HZR12_RS05620 ENOG4105E8V Alpha Beta Hydrolase Fold protein HZR12_RS05640 ENOG4105N5T Radical SAM Protein HZR12_RS05645 ENOG410605W Major Facilitator HZR12_RS05665 ENOG4105CBX hi0933 family HZR12_RS05690 ENOG4105F0I Aminotransferase HZR12_RS05695 ENOG4108V15 phosphotransferase enzyme family HZR12_RS05705 ENOG4105C8F Beta-lactamase domain protein HZR12_RS05730 ENOG4108VDD TRNA binding domain protein HZR12_RS05760 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HZR12_RS05770 ENOG4105ETE Transcriptional regulator (LacI family HZR12_RS05775 ENOG4105DGU Histone deacetylase HZR12_RS05780 ENOG4105F1V Acetoin utilization protein HZR12_RS05790 ENOG4105CKU formyltetrahydrofolate synthetase HZR12_RS05820 ENOG4105C0H protease HZR12_RS05825 ENOG4105F6E Acyl-transferase HZR12_RS05845 ENOG4108JQ1 Dehydrogenase HZR12_RS05850 ENOG4105C5R Aminotransferase HZR12_RS05855 ENOG4108X3M OsmC Ohr family protein HZR12_RS05860 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HZR12_RS05900 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HZR12_RS05950 ENOG4105SFS phosphoesterase RecJ domain protein HZR12_RS05955 ENOG4105C0B DNA polymerase III (alpha subunit) HZR12_RS05960 ENOG4105C6K Malic enzyme HZR12_RS05990 ENOG4105C85 amino acid HZR12_RS05995 ENOG4105BZN citrate synthase HZR12_RS06000 ENOG4108HMX isocitrate dehydrogenase (NADP) HZR12_RS06005 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HZR12_RS06010 ENOG4105BZU Histidine kinase HZR12_RS06020 ENOG4105C2M dna polymerase I HZR12_RS06030 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HZR12_RS06035 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HZR12_RS06060 ENOG4105C22 threonyL-tRNA synthetase HZR12_RS06065 ENOG4108IQI permease HZR12_RS06085 ENOG4105U6W MutT NUDIX family protein HZR12_RS06115 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HZR12_RS06135 ENOG4105D52 delta-aminolevulinic acid dehydratase HZR12_RS06155 ENOG4108R3E Dna-3-methyladenine glycosylase i HZR12_RS06165 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HZR12_RS06170 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) HZR12_RS06215 ENOG4105X36 (ribosomal) protein HZR12_RS06255 ENOG4105VIE preprotein translocase, subunit YajC HZR12_RS06260 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HZR12_RS06265 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HZR12_RS06285 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HZR12_RS06295 ENOG4105C9M aspartyl-trna synthetase HZR12_RS06310 ENOG4105CUZ uba thif-type nad fad binding protein HZR12_RS06315 ENOG4105D1H recombination factor protein RarA HZR12_RS06325 ENOG41061M1 UPF0337 protein HZR12_RS06335 ENOG4105DEN Luciferase family HZR12_RS06340 ENOG4105C3J Cysteine desulfurase HZR12_RS06355 ENOG4105C7H Helicase, RecD TraA family HZR12_RS06385 ENOG4105XYU peptidase (U32 family) HZR12_RS06390 ENOG4105CFP Peptidase U32 HZR12_RS06405 ENOG4105P4J Allophanate hydrolase, subunit 1 HZR12_RS06415 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HZR12_RS06420 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HZR12_RS06430 ENOG4105C5A transporter HZR12_RS06455 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase HZR12_RS06460 ENOG4105CQW ribosome biogenesis GTPase YqeH HZR12_RS06470 ENOG410812S Rna-binding protein HZR12_RS06480 ENOG4108WF2 Metal Dependent Phosphohydrolase HZR12_RS06485 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HZR12_RS06490 ENOG4105DXX methyltransferase HZR12_RS06500 ENOG4108UK2 deaminase HZR12_RS06505 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 HZR12_RS06510 ENOG4105TQK DNA polymerase iii, delta' subunit HZR12_RS06525 ENOG4105CSA Coproporphyrinogen iii oxidase HZR12_RS06555 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HZR12_RS06560 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HZR12_RS06570 ENOG4105F7J membrane-bound serine protease HZR12_RS06585 ENOG4105C9A Phoh family HZR12_RS06600 ENOG4105KG3 cytidine deaminase HZR12_RS06605 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HZR12_RS06630 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HZR12_RS06635 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HZR12_RS06645 ENOG4105EGD dinuclear metal center protein, YbgI family HZR12_RS06650 ENOG4105C1J atp-dependent rna helicase HZR12_RS06660 ENOG4105FDK ABC transporter HZR12_RS06665 ENOG4105FAV ABC, transporter HZR12_RS06670 ENOG4105N80 Ferric uptake regulator, Fur family HZR12_RS06675 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HZR12_RS06680 ENOG4107RF6 penicillin-binding protein HZR12_RS06690 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HZR12_RS06715 ENOG4105C5X domain protein HZR12_RS06730 ENOG4106855 Competence protein HZR12_RS06775 ENOG4105WZW rhodanese family HZR12_RS06780 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) HZR12_RS06795 ENOG4105DC7 peptidase M24 HZR12_RS06810 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HZR12_RS06815 ENOG4108ZSR alkaline shock protein HZR12_RS06845 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HZR12_RS06860 ENOG4105CPP Dehydrogenase, E1 component HZR12_RS06865 ENOG4105C7S Dehydrogenase HZR12_RS06875 ENOG4108QEG Membrane HZR12_RS06885 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HZR12_RS06920 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HZR12_RS06930 ENOG4105II7 pyrroline-5-carboxylate reductase HZR12_RS06935 ENOG4105PDP Short chain dehydrogenase HZR12_RS06945 ENOG4105CPC Aldo Keto reductase HZR12_RS06950 ENOG4108YZ4 nudix hydrolase HZR12_RS06955 ENOG4105I3K Ferric uptake regulator, Fur family HZR12_RS06960 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HZR12_RS06980 ENOG4105FE9 pseudouridine synthase HZR12_RS06985 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HZR12_RS06990 ENOG4105BZU Histidine kinase HZR12_RS07045 ENOG4105C9U ATP-dependent DNA helicase RecQ HZR12_RS07060 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase HZR12_RS07065 ENOG4105HDK L-asparaginase HZR12_RS07085 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HZR12_RS07100 ENOG4105K70 DNA-binding protein HZR12_RS07115 ENOG4105EAH synthase HZR12_RS07135 ENOG4105D49 3-dehydroquinate synthase HZR12_RS07150 ENOG4105QKB UPF0302 protein HZR12_RS07165 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase HZR12_RS07170 ENOG4105CPK Glycosyl transferase (Group 1 HZR12_RS07200 ENOG4105CSM endonuclease III HZR12_RS07210 ENOG4105BZ4 penicillin-binding protein HZR12_RS07245 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HZR12_RS07260 ENOG410890F Dynamin family HZR12_RS07270 ENOG4105DCF alanine dehydrogenase HZR12_RS07280 ENOG4107R7I amino acid HZR12_RS07290 ENOG41063K0 cell wall associated fibronectin-binding protein HZR12_RS07315 ENOG4106QQ5 PBS lyase HEAT domain protein repeat-containing protein HZR12_RS07330 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HZR12_RS07335 ENOG4108RCR degv family HZR12_RS07350 ENOG4105C5Y PTS System HZR12_RS07360 ENOG4105CN1 protease HZR12_RS07370 ENOG4105DQ6 Transposase HZR12_RS07385 ENOG410841Q phosphoesterase PA-phosphatase related protein HZR12_RS07400 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HZR12_RS07430 ENOG4105GMT ATPase associated with various cellular activities aaa_5 HZR12_RS07435 ENOG4107T89 von Willebrand factor, type A HZR12_RS07480 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HZR12_RS07485 ENOG4108XFP Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HZR12_RS07510 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HZR12_RS07515 ENOG4105CFH Aspartokinase HZR12_RS07520 ENOG4105C5H ABC transporter HZR12_RS07540 ENOG4105C8U phosphate abc transporter HZR12_RS07545 ENOG4105E2Z phosphate ABC transporter (Permease HZR12_RS07550 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HZR12_RS07555 ENOG4108UTW Plays a role in the regulation of phosphate uptake HZR12_RS07560 ENOG4105DPN Oligoendopeptidase f HZR12_RS07600 ENOG4108KP7 hydrolase HZR12_RS07605 ENOG4108TV1 Catalyzes the incorporation of amino acid(s) into the interchain peptide bridge of peptidoglycan, using aminoacyl-tRNA as amino acid donor (By similarity) HZR12_RS07640 ENOG4105DDQ anthranilate synthase HZR12_RS07645 ENOG4105CRQ synthase (Component I) HZR12_RS07650 ENOG4105DER m42 family HZR12_RS07660 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HZR12_RS07670 ENOG4108RCF TRANSCRIPTIONal HZR12_RS07675 ENOG4108FKN Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HZR12_RS07680 ENOG4105FF5 Membrane HZR12_RS07705 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HZR12_RS07730 ENOG4108I0Z Aconitate hydratase HZR12_RS07735 ENOG4105C94 Transporter HZR12_RS07770 ENOG4105CV1 Transketolase (EC 2.2.1.1) HZR12_RS07775 ENOG4105VPS UPF0291 protein HZR12_RS07790 ENOG4105K4I Scp-like extracellular HZR12_RS07815 ENOG4108IQI permease HZR12_RS07840 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) HZR12_RS07845 ENOG4105D6E homoserine dehydrogenase HZR12_RS07850 ENOG4105CFH Aspartokinase HZR12_RS07875 ENOG4108S01 response regulator HZR12_RS07890 ENOG4108M15 ABC transporter HZR12_RS07895 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HZR12_RS07980 ENOG4105DQ6 Transposase HZR12_RS08005 ENOG4105KV4 Transcriptional regulator HZR12_RS08010 ENOG4105CXI aluminum resistance protein HZR12_RS08015 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HZR12_RS08020 ENOG4108V06 Glutathione peroxidase HZR12_RS08025 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) HZR12_RS08050 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HZR12_RS08055 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HZR12_RS08090 ENOG4105DQU oxidoreductase, subunit beta HZR12_RS08095 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein HZR12_RS08100 ENOG4105D48 metallophosphoesterase HZR12_RS08120 ENOG4105CEV competence damage-inducible protein HZR12_RS08125 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase HZR12_RS08140 ENOG4108RKS Short-chain dehydrogenase reductase Sdr HZR12_RS08155 ENOG4105FDP GntR family transcriptional regulator HZR12_RS08160 ENOG4105CNU cell division protein FtsK HZR12_RS08180 ENOG4105DTN riboflavin biosynthesis protein ribF HZR12_RS08200 ENOG4105VHM ribosomal protein HZR12_RS08205 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination HZR12_RS08210 ENOG4105CHV Transcription elongation factor NusA HZR12_RS08230 ENOG4105DZP Membrane-associated zinc metalloprotease HZR12_RS08235 ENOG4105KNE Phosphatidate cytidylyltransferase HZR12_RS08240 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HZR12_RS08305 ENOG4105C79 DNA protecting protein DprA HZR12_RS08315 ENOG41068KG domain protein HZR12_RS08320 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HZR12_RS08335 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) HZR12_RS08375 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HZR12_RS08380 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HZR12_RS08395 ENOG4105CHR reductase HZR12_RS08400 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HZR12_RS08415 ENOG4105CB5 ATP-dependent DNA helicase recG HZR12_RS08425 ENOG4105DQ6 Transposase HZR12_RS08435 ENOG4108ZAA Alkaline-shock protein HZR12_RS08450 ENOG4105DJV ribulose-phosphate 3-epimerase HZR12_RS08455 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HZR12_RS08465 ENOG4108ZF3 Phosphatase HZR12_RS08475 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HZR12_RS08485 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HZR12_RS08490 ENOG4105YB8 TM2 domain containing protein HZR12_RS08500 ENOG4105C25 Primosomal protein n' HZR12_RS08505 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HZR12_RS08535 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HZR12_RS08550 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HZR12_RS08555 ENOG4105CD3 dihydroorotase HZR12_RS08575 ENOG4105C34 Pseudouridine synthase HZR12_RS08590 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase HZR12_RS08605 ENOG4105DBK s4 domain protein HZR12_RS08610 ENOG41067XK integral membrane protein HZR12_RS08620 ENOG4105DFA alanine racemase domain protein HZR12_RS08625 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HZR12_RS08630 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HZR12_RS08635 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HZR12_RS08640 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) HZR12_RS08655 ENOG4105CJN penicillin-binding protein HZR12_RS08660 ENOG41068DC Essential cell division protein (By similarity) HZR12_RS08720 ENOG4105CSX c4-dicarboxylate anaerobic carrier HZR12_RS08760 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity HZR12_RS08825 ENOG4105E33 succinate dehydrogenase HZR12_RS08835 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit HZR12_RS08850 ENOG4105K63 Thioredoxin HZR12_RS08860 ENOG4105DCG PHP domain protein HZR12_RS08880 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HZR12_RS08890 ENOG4108RWN rrna methyltransferase HZR12_RS08905 ENOG4105KFN sortase, SrtB family HZR12_RS08960 ENOG4106H78 methyltransferase HZR12_RS09010 ENOG4105CNI cell division protein FtsW HZR12_RS09030 ENOG4105CI3 gtp-binding protein typa HZR12_RS09040 ENOG4105ECY inositol monophosphatase HZR12_RS09065 ENOG4107RUE extracellular solute-binding protein family 1 HZR12_RS09070 ENOG4105D38 putrescine abc transporter HZR12_RS09075 ENOG4105F38 ABC transporter, permease HZR12_RS09095 ENOG4107QN2 dihydrolipoyl dehydrogenase HZR12_RS09100 ENOG4105C7S Dehydrogenase HZR12_RS09105 ENOG4105CPP Dehydrogenase, E1 component HZR12_RS09110 ENOG4107RUY (E1 component), alpha subunit HZR12_RS09120 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HZR12_RS09140 ENOG4107ZYR domain protein HZR12_RS09160 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HZR12_RS09165 ENOG4105KRI phosphocarrier protein (HPr HZR12_RS09175 ENOG4105DR4 Methyltransferase HZR12_RS09190 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein HZR12_RS09195 ENOG4108JJB ABC transporter HZR12_RS09200 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) HZR12_RS09205 ENOG4105C12 Phosphoribosylglycinamide synthetase HZR12_RS09210 ENOG4105DC1 bifunctional purine biosynthesis protein purh HZR12_RS09215 ENOG4108V3E phosphoribosylglycinamide formyltransferase HZR12_RS09225 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HZR12_RS09240 ENOG4105VR9 phosphoribosylformylglycinamidine synthase HZR12_RS09250 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HZR12_RS09255 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HZR12_RS09295 ENOG4105FQP Beta-lactamase HZR12_RS09300 ENOG4108KGH TRANSCRIPTIONal HZR12_RS09310 ENOG4108HPG -acetyltransferase HZR12_RS09330 ENOG4108TGC Acyltransferase HZR12_RS09335 ENOG4105CHM Aminotransferase HZR12_RS09340 ENOG4108CHM Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases HZR12_RS09355 ENOG4108IPT Naphthoate synthase HZR12_RS09360 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) HZR12_RS09370 ENOG4105E4F Isochorismate synthase HZR12_RS09375 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HZR12_RS09380 ENOG41080E2 ribosomal-protein-alanine acetyltransferase HZR12_RS09385 ENOG4105YB8 TM2 domain containing protein HZR12_RS09395 ENOG4108HUF Transporter HZR12_RS09420 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HZR12_RS09470 ENOG4105XVF Competence transcription factor HZR12_RS09485 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HZR12_RS09495 ENOG4105C0H protease HZR12_RS09500 ENOG4107TS3 membrane protein, TerC HZR12_RS09540 ENOG4105BZG amino acid carrier protein HZR12_RS09545 ENOG4105C02 permease HZR12_RS09560 ENOG4105CJW magnesium transporter HZR12_RS09565 ENOG4105EMS pseudouridine synthase HZR12_RS09590 ENOG4108Z18 K06886 hemoglobin HZR12_RS09600 ENOG4105DPN Oligoendopeptidase f HZR12_RS09615 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) HZR12_RS09620 ENOG4105C31 Tryptophanyl-tRNA synthetase HZR12_RS09625 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HZR12_RS09635 ENOG4108JQ7 (ABC) transporter HZR12_RS09645 ENOG4105DEF Extracellular solute-binding protein, family 5 HZR12_RS09655 ENOG4108JQ7 (ABC) transporter HZR12_RS09665 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HZR12_RS09670 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HZR12_RS09680 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HZR12_RS09700 ENOG4105KIS phospholipid-binding protein HZR12_RS09725 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HZR12_RS09730 ENOG4105EXC Acyl-transferase HZR12_RS09740 ENOG4108KP7 hydrolase HZR12_RS09770 ENOG4105C3F Signal peptidase i HZR12_RS09800 ENOG4107VXM glycerophosphoryl diester phosphodiesterase HZR12_RS09805 ENOG4105D82 Glutamate dehydrogenase HZR12_RS09810 ENOG4105C8Y Acetylornithine aminotransferase HZR12_RS09815 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HZR12_RS09820 ENOG41060GV RNA binding s1 domain protein HZR12_RS09840 ENOG4106128 DNA-binding helix-turn-helix protein HZR12_RS09865 ENOG4106BHR ftsk SpoIIIE family protein HZR12_RS09875 ENOG41068JE domain protein HZR12_RS09895 ENOG4105F9F transposase HZR12_RS09950 ENOG4105KA0 thioesterase Superfamily protein HZR12_RS09960 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HZR12_RS09970 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HZR12_RS09990 ENOG41083MR nifu domain-containing protein HZR12_RS09995 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD HZR12_RS10005 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HZR12_RS10045 ENOG4105MMD transcriptional regulator HZR12_RS10065 ENOG4105I3N Conserved Protein HZR12_RS10120 ENOG4105ZMJ n-acetylmuramoyl-l-alanine amidase HZR12_RS10155 ENOG4105DR5 peptidase HZR12_RS10210 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HZR12_RS10255 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HZR12_RS10310 ENOG4106CVF DNA replication protein HZR12_RS10335 ENOG4108UUM single-stranded DNA-binding protein HZR12_RS10425 ENOG4108UNV SUF system FeS assembly protein, NifU family HZR12_RS10430 ENOG4105C9B Cysteine desulfurase HZR12_RS10435 ENOG4105JRK feS assembly protein SufD HZR12_RS10440 ENOG4105C3K feS assembly ATPase SufC HZR12_RS10455 ENOG4105D01 (LipO)protein HZR12_RS10460 ENOG4108UMI ABC transporter, permease HZR12_RS10480 ENOG4108XI2 Domain of unknown function (DUF1963) HZR12_RS10490 ENOG41080E8 Transcriptional regulator, Spx MgsR family HZR12_RS10495 ENOG4105SZ6 Thioredoxin HZR12_RS10520 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HZR12_RS10525 ENOG4105CVJ phosphoglycerate mutase HZR12_RS10565 ENOG4105VEQ Cold shock protein HZR12_RS10570 ENOG4107Y9E nuclease HZR12_RS10650 ENOG4108TFU terminase (Small subunit) HZR12_RS10750 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HZR12_RS10760 ENOG4105XZU Preprotein translocase, subunit SecG HZR12_RS10775 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HZR12_RS10790 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HZR12_RS10820 ENOG4105CHW UPF0052 protein HZR12_RS10830 ENOG4105C3M thioredoxin reductase HZR12_RS10840 ENOG4108S4C acetyltransferase HZR12_RS10855 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HZR12_RS10860 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HZR12_RS10875 ENOG41068JE domain protein HZR12_RS10905 ENOG41081UC Inherit from COG: Competence protein HZR12_RS10915 ENOG4105EPR degv family HZR12_RS10920 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HZR12_RS10925 ENOG4105ESV Glycosyl transferase, family 4 HZR12_RS10985 ENOG4108IPW abc transporter atp-binding protein HZR12_RS10990 ENOG4105CM4 permease protein HZR12_RS10995 ENOG4105DHS permease protein HZR12_RS11005 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HZR12_RS11010 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HZR12_RS11030 ENOG4105DUX Transporter HZR12_RS11045 ENOG4108ZIE 5 nucleotidase deoxy cytosolic type C HZR12_RS11055 ENOG4105E90 ABC transporter HZR12_RS11060 ENOG4108IJ8 ABC transporter HZR12_RS11065 ENOG4105C9U ATP-dependent DNA helicase RecQ HZR12_RS11070 ENOG4105C5H ABC transporter HZR12_RS11100 ENOG4105CRQ synthase (Component I) HZR12_RS11105 ENOG4105DDQ anthranilate synthase HZR12_RS11115 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase HZR12_RS11120 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HZR12_RS11155 ENOG4105DQ6 Transposase HZR12_RS11160 ENOG4105CKK Glycosyl transferase, family 2 HZR12_RS11170 ENOG4105C37 (CBS) domain HZR12_RS11175 ENOG4105CE4 GlcNAc 6-P deacetylase HZR12_RS11180 ENOG4105DM4 PTS System HZR12_RS11185 ENOG4105DE4 1-phosphofructokinase HZR12_RS11190 ENOG4105E98 transcriptional regulator DeoR family HZR12_RS11195 ENOG4108Z66 YbaK ebsC protein HZR12_RS11205 ENOG4105DP8 Major facilitator superfamily MFS_1 HZR12_RS11225 ENOG4105CVP deoxyribo-dipyrimidine photolyase HZR12_RS11230 ENOG4107QPK )-transporter HZR12_RS11240 ENOG4107QM2 Aldo Keto reductase HZR12_RS11245 ENOG4105CKI cobalamin synthesis protein HZR12_RS11250 ENOG4105K56 Transcriptional regulator HZR12_RS11255 ENOG4108JJ8 (ABC) transporter HZR12_RS11260 ENOG4108JJ9 ABC, transporter HZR12_RS11280 ENOG4108URH decarboxylase HZR12_RS11285 ENOG4108YYQ gCN5-related N-acetyltransferase HZR12_RS11310 ENOG4105SXS Protein of unknown function (DUF456) HZR12_RS11315 ENOG4105S8Q sugar efflux transporter HZR12_RS11350 ENOG4105ID8 Transcriptional regulator, ARAC family HZR12_RS11360 ENOG4105VRS hydrolase family 18 HZR12_RS11365 ENOG4105CJ3 phosphate transporter HZR12_RS11370 ENOG4107GRR phosphate transport regulator HZR12_RS11380 ENOG4105C19 ABC transporter HZR12_RS11415 ENOG4108K88 Membrane HZR12_RS11425 ENOG4105VDH Dihydroxyacetone kinase HZR12_RS11435 ENOG4105CMT Dihydroxyacetone kinase HZR12_RS11440 ENOG4105EHG Permease protein HZR12_RS11445 ENOG4105DQ5 transport system permease protein HZR12_RS11450 ENOG4105E0A ABC, transporter HZR12_RS11455 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) HZR12_RS11470 ENOG4105BZ1 (ABC) transporter HZR12_RS11480 ENOG4107YSK Glycerol-3-phosphate cytidylyltransferase HZR12_RS11505 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family HZR12_RS11515 ENOG4107R5H iron (metal) dependent repressor, dtxr family HZR12_RS11520 ENOG4105DIK (ABC) transporter HZR12_RS11525 ENOG4105CC5 ABC transporter HZR12_RS11530 ENOG4105DSE periplasmic solute binding protein HZR12_RS11535 ENOG4105EEQ Na H antiporter HZR12_RS11575 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off HZR12_RS11615 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HZR12_RS11630 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HZR12_RS11660 ENOG4108XFG YwhD family HZR12_RS11665 ENOG4105DCI Phosphohydrolase HZR12_RS11675 ENOG4108WS4 fmn reductase HZR12_RS11680 ENOG4105CPC Aldo Keto reductase HZR12_RS11765 ENOG4107QN2 dihydrolipoyl dehydrogenase HZR12_RS11785 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HZR12_RS11790 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) HZR12_RS11795 ENOG4108IJ2 phosphate acetyltransferase HZR12_RS11835 ENOG4105DWF phosphomethylpyrimidine kinase HZR12_RS11860 ENOG4107F3J Amp-dependent synthetase and ligase HZR12_RS11865 ENOG4105CSH Transporter HZR12_RS11880 ENOG4108VA3 3-hexulose-6-phosphate synthase HZR12_RS11895 ENOG4107YEI lmbE family HZR12_RS11925 ENOG410667J hydrolase HZR12_RS11930 ENOG4108Z6B deaminase HZR12_RS11940 ENOG4105ZMH deoxynucleoside kinase HZR12_RS11945 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HZR12_RS11950 ENOG4105CM2 brancheD-chain amino acid aminotransferase HZR12_RS11970 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HZR12_RS12005 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HZR12_RS12015 ENOG4107Y49 methyltransferase HZR12_RS12040 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HZR12_RS12045 ENOG410683Z Preprotein translocase SecE subunit HZR12_RS12065 ENOG4105C2N RNA methyltransferase TrmH family group 3 HZR12_RS12070 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) HZR12_RS12090 ENOG4105CTP PilT protein domain protein HZR12_RS12095 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HZR12_RS12110 ENOG4108Z0C Uvrb UvrC protein HZR12_RS12120 ENOG4105D9N nucleoside HZR12_RS12135 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HZR12_RS12230 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HZR12_RS12235 ENOG4105KRF dihydroneopterin aldolase HZR12_RS12245 ENOG4105C6T cysteine synthase HZR12_RS12255 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HZR12_RS12260 ENOG4108UGV hypoxanthine phosphoribosyltransferase HZR12_RS12265 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HZR12_RS12270 ENOG41060GV RNA binding s1 domain protein HZR12_RS12280 ENOG41082I2 s4 domain protein HZR12_RS12285 ENOG4108IY2 MazG family HZR12_RS12310 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HZR12_RS12330 ENOG4105KME endoribonuclease L-psp HZR12_RS12335 ENOG4105DFT pur operon repressor HZR12_RS12345 ENOG4105W42 Veg protein HZR12_RS12355 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) HZR12_RS12360 ENOG4105F8V Hydrolase, tatD family HZR12_RS12365 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HZR12_RS12370 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HZR12_RS12380 ENOG41060K3 Methyltransferase HZR12_RS12390 ENOG4105MA4 psp1 domain protein HZR12_RS12395 ENOG4105FA2 dna polymerase iii HZR12_RS12400 ENOG4105X0R protein from nitrogen regulatory protein P-II HZR12_RS12410 ENOG4105CXN decarboxylase HZR12_RS12445 ENOG4105C6E dna polymerase iii HZR12_RS12465 ENOG4107414 GntR family transcriptional regulator HZR12_RS12470 ENOG4105CG3 alpha amylase, catalytic region HZR12_RS12475 ENOG4105C5Y PTS System HZR12_RS12485 ENOG4105BZ8 glutamate synthase HZR12_RS12490 ENOG4105CBC glutamate synthase HZR12_RS12495 ENOG4105C5Q Transcriptional regulator HZR12_RS12525 ENOG41068JE domain protein HZR12_RS12530 ENOG4105D01 (LipO)protein HZR12_RS12535 ENOG4108UMI ABC transporter, permease HZR12_RS12545 ENOG4105C28 cystathionine HZR12_RS12555 ENOG4105C8J )-transporter HZR12_RS12580 ENOG4105GPN Uncharacterized conserved protein (DUF2294) HZR12_RS12590 ENOG4108TWJ NADH dehydrogenase subunit 5 HZR12_RS12615 ENOG4105CKI cobalamin synthesis protein HZR12_RS12770 ENOG4105KA3 membrAne HZR12_RS12800 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HZR12_RS12805 ENOG4105C2W permease HZR12_RS12835 ENOG4107R6U sodium dicarboxylate symporter HZR12_RS12845 ENOG4105D3R alkyl hydroperoxide reductase HZR12_RS12850 ENOG4108JU3 Alkyl hydroperoxide reductase HZR12_RS12940 ENOG4108TFU terminase (Small subunit) HZR12_RS13040 ENOG4108UUM single-stranded DNA-binding protein HZR12_RS13055 ENOG4105C3G gtp-binding protein HZR12_RS13060 ENOG4105VDK protein, conserved in bacteria HZR12_RS13065 ENOG4105D8X mechanosensitive ion channel HZR12_RS13070 ENOG4105FA0 parb-like partition protein HZR12_RS13075 ENOG4105C28 cystathionine HZR12_RS13080 ENOG4105C28 cystathionine HZR12_RS13115 ENOG4105DA5 (ABC) transporter HZR12_RS13125 ENOG4105VZ8 Transcriptional regulator HZR12_RS13135 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HZR12_RS13140 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HZR12_RS13145 ENOG4107SJW iron permease, FTR1 HZR12_RS13155 ENOG410650H (LipO)protein HZR12_RS13170 ENOG4105HMI Membrane HZR12_RS13175 ENOG4107V0Z fmn reductase HZR12_RS13190 ENOG4105CXY transporter HZR12_RS13210 ENOG4105CID antiterminator HZR12_RS13215 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HZR12_RS13225 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HZR12_RS13245 ENOG4108UVJ appr-1-p processing domain protein HZR12_RS13255 ENOG4105DEN Luciferase family HZR12_RS13280 ENOG4105DWD nucleoside recognition domain protein HZR12_RS13290 ENOG4106KNT transcriptional regulator HZR12_RS13295 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) HZR12_RS13305 ENOG4107RJ1 sodium solute HZR12_RS13310 ENOG4105D9N nucleoside HZR12_RS13335 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) HZR12_RS13340 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family HZR12_RS13435 ENOG4105DQ6 Transposase HZR12_RS13510 ENOG4105VRS hydrolase family 18 HZR12_RS13540 ENOG4105DA5 (ABC) transporter HZR12_RS13570 ENOG4105EV1 Ribose uptake protein RbsU HZR12_RS13590 ENOG4105DVA methyltransferase HZR12_RS13595 ENOG4105CS2 ec 3.2.1.21 HZR12_RS13600 ENOG4105CI1 PTS System HZR12_RS13625 ENOG4108HRK Histidine kinase HZR12_RS13635 ENOG4107SJB teichoic acid biosynthesis HZR12_RS13660 ENOG4107YSK Glycerol-3-phosphate cytidylyltransferase HZR12_RS13675 ENOG4108IAJ Nad-dependent epimerase dehydratase HZR12_RS13680 ENOG4105DU0 nucleoside hydrolase HZR12_RS13685 ENOG4105CI1 PTS System HZR12_RS13710 ENOG4105K78 MarR family Transcriptional regulator HZR12_RS13715 ENOG4107RRN ABC transporter substrate-binding protein HZR12_RS13720 ENOG4105ENX hydrolase HZR12_RS13745 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HZR12_RS13750 ENOG4105CEY Amp-dependent synthetase and ligase HZR12_RS13755 ENOG4105C1G acyl-Coa dehydrogenase HZR12_RS13760 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HZR12_RS13765 ENOG4105CHU acetyl-coa acetyltransferase HZR12_RS13815 ENOG4105CXY transporter HZR12_RS13820 ENOG4108WWS isoprenylcysteine carboxyl methyltransferase HZR12_RS13830 ENOG4105CK5 oxidoreductase HZR12_RS13840 ENOG4105EG2 ABC transporter, permease HZR12_RS13875 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HZR12_RS13900 ENOG4106128 DNA-binding helix-turn-helix protein HZR12_RS13925 ENOG4106BHR ftsk SpoIIIE family protein HZR12_RS13960 ENOG4105F9F transposase HZR12_RS13970 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HZR12_RS14000 ENOG4105QEK Transcriptional regulator HZR12_RS14030 ENOG4107RA9 decarboxylase HZR12_RS14035 ENOG4105D3W isochorismatase HZR12_RS14040 ENOG4105CWM branched-chain amino acid transport system II carrier protein HZR12_RS14045 ENOG4105C8Y Acetylornithine aminotransferase HZR12_RS14055 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HZR12_RS14070 ENOG4105DQ6 Transposase HZR12_RS14085 ENOG4105HMI Membrane HZR12_RS14120 ENOG4108BUD transposase HZR12_RS14130 ENOG4108RS6 transposase HZR12_RS14145 ENOG4105BZ1 (ABC) transporter HZR12_RS14150 ENOG4105BZ1 (ABC) transporter HZR12_RS14155 ENOG4108BUD transposase HZR12_RS14170 ENOG41067QW Transcriptional regulator HZR12_RS14195 ENOG4105CJ1 ABC, transporter HZR12_RS14225 ENOG4108JJA ABC, transporter HZR12_RS14245 ENOG4108BUD transposase HZR12_RS14270 ENOG4105DQ6 Transposase HZR12_RS14280 ENOG4108U05 Transcriptional regulator HZR12_RS14310 ENOG4105DBV ornithine carbamoyltransferase HZR12_RS14350 ENOG4105DM4 PTS System HZR12_RS14355 ENOG4105DG6 mannose-6-phosphate isomerase HZR12_RS14365 ENOG4108S4A n-acetylmuramoyl-l-alanine amidase HZR12_RS14370 ENOG4105WQI isochorismatase HZR12_RS14395 ENOG4106E62 Accessory Sec system protein Asp3 HZR12_RS14400 ENOG41089G2 accessory Sec system protein Asp2 HZR12_RS14420 ENOG4105EW6 flavin reductase domain protein, FMN-binding HZR12_RS14440 ENOG4107XC4 flavin reductase domain protein, FMN-binding HZR12_RS14445 ENOG4108F19 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HZR12_RS14465 ENOG4105HTX biosynthesis protein HZR12_RS14495 ENOG4105J1V Triacylglycerol lipase HZR12_RS14505 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HZR12_RS14530 ENOG4105CIH Imidazole acetol-phosphate transaminase HZR12_RS14605 ENOG4107QPK )-transporter HZR12_RS14610 ENOG4105FR1 rard protein HZR12_RS14620 ENOG4105D9G High-affinity HZR12_RS14635 ENOG4105C19 ABC transporter HZR12_RS14650 ENOG4105VEQ Cold shock protein HZR12_RS14670 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity)