locus-tag	class	description
HA035_RS00020	COG2183	response to ionizing radiation
HA035_RS00025	COG1191	sigma factor activity
HA035_RS00035	COG1366	Belongs to the anti-sigma-factor antagonist family
HA035_RS00040	COG2208	phosphoserine phosphatase activity
HA035_RS00070	COG3428	Bacterial PH domain
HA035_RS00100	COG2205	protein histidine kinase activity
HA035_RS00105	COG0745	RESPONSE REGULATOR receiver
HA035_RS00115	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HA035_RS00125	COG0772	Belongs to the SEDS family
HA035_RS00140	COG1937	Protein conserved in bacteria
HA035_RS00150	COG1418	mRNA catabolic process
HA035_RS00185	COG0629	single-stranded DNA binding
HA035_RS00260	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HA035_RS00285	COG0009	L-threonylcarbamoyladenylate synthase
HA035_RS00290	COG2890	protein-(glutamine-N5) methyltransferase activity
HA035_RS00310	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HA035_RS00350	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HA035_RS00395	COG0813	purine-nucleoside phosphorylase activity
HA035_RS00400	COG0783	Belongs to the Dps family
HA035_RS00420	COG1482	cell wall glycoprotein biosynthetic process
HA035_RS00425	COG0702	epimerase
HA035_RS00430	COG0640	Transcriptional regulator
HA035_RS00465	COG0561	phosphatase activity
HA035_RS00470	COG1119	ATPase activity
HA035_RS00485	COG3711	transcriptional antiterminator
HA035_RS00515	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HA035_RS00585	COG0489	protein tyrosine kinase activity
HA035_RS00590	COG2814	Major facilitator Superfamily
HA035_RS00605	COG1272	protein, Hemolysin III
HA035_RS00615	COG1988	membrane-bound metal-dependent
HA035_RS00630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HA035_RS00635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HA035_RS00640	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HA035_RS00650	COG3457	Alanine racemase
HA035_RS00655	COG4264	IucA IucC family
HA035_RS00660	COG2814	Major facilitator Superfamily
HA035_RS00690	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HA035_RS00700	COG2130	NADP-dependent
HA035_RS00750	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HA035_RS00770	COG0656	L-ascorbic acid biosynthetic process
HA035_RS00775	COG0789	Transcriptional regulator
HA035_RS00785	COG5492	domain, Protein
HA035_RS00805	COG3527	Alpha-acetolactate decarboxylase
HA035_RS00810	COG0028	Belongs to the TPP enzyme family
HA035_RS00830	COG0542	response to heat
HA035_RS00915	COG0201	protein transport
HA035_RS01030	COG2252	PERMEase
HA035_RS01075	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HA035_RS01135	COG1763	Mo-molybdopterin cofactor biosynthetic process
HA035_RS01155	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HA035_RS01160	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HA035_RS01165	COG4149	molybdate abc transporter
HA035_RS01170	COG0725	ABC transporter, periplasmic molybdate-binding protein
HA035_RS01185	COG1268	BioY protein
HA035_RS01200	COG1960	acyl-CoA dehydrogenase activity
HA035_RS01205	COG4413	Urea transporter
HA035_RS01265	COG3942	CHAP domain
HA035_RS01275	COG1757	Na H antiporter
HA035_RS01290	COG3942	CHAP domain
HA035_RS01360	COG1113	amino acid transport
HA035_RS01380	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HA035_RS01385	COG0385	Bile acid
HA035_RS01395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HA035_RS01395	COG1263	PTS System
HA035_RS01400	COG1737	Transcriptional regulator
HA035_RS01420	COG1028	Short-chain dehydrogenase reductase Sdr
HA035_RS01425	COG1473	amidohydrolase
HA035_RS01440	COG0583	DNA-binding transcription factor activity
HA035_RS01465	COG2258	MOSC domain
HA035_RS01485	COG1668	transmembrane transport
HA035_RS01490	COG4152	abc transporter atp-binding protein
HA035_RS01495	COG3152	Membrane
HA035_RS01505	COG0786	glutamate:sodium symporter activity
HA035_RS01515	COG0598	Magnesium transport protein CorA
HA035_RS01530	COG0657	acetylesterase activity
HA035_RS01540	COG2814	Major facilitator Superfamily
HA035_RS01545	COG1566	PFAM secretion protein HlyD family protein
HA035_RS01555	COG2814	Major facilitator Superfamily
HA035_RS01620	COG1620	l-lactate permease
HA035_RS01640	COG0604	alcohol dehydrogenase
HA035_RS01645	COG0456	acetyltransferase
HA035_RS01665	COG1511	domain protein
HA035_RS01680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HA035_RS01680	COG1263	PTS System
HA035_RS01695	COG3871	stress protein (general stress protein 26)
HA035_RS01740	COG0789	Transcriptional regulator
HA035_RS01760	COG2181	nitrate reductase activity
HA035_RS01770	COG1140	nitrate reductase beta subunit
HA035_RS01775	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HA035_RS01785	COG2146	nitrite reductase [NAD(P)H] activity
HA035_RS01790	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HA035_RS01800	COG0454	-acetyltransferase
HA035_RS01805	COG2116	formate transmembrane transporter activity
HA035_RS01820	COG3443	Belongs to the bacterial solute-binding protein 9 family
HA035_RS01820	COG0803	Belongs to the bacterial solute-binding protein 9 family
HA035_RS01860	COG1126	abc transporter atp-binding protein
HA035_RS01865	COG0765	amino acid transport
HA035_RS01870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HA035_RS01875	COG2814	Major facilitator Superfamily
HA035_RS01890	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HA035_RS01930	COG0156	8-amino-7-oxononanoate synthase activity
HA035_RS01940	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HA035_RS01945	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HA035_RS01955	COG1132	(ABC) transporter
HA035_RS01975	COG1929	Belongs to the glycerate kinase type-1 family
HA035_RS01985	COG2814	Major facilitator Superfamily
HA035_RS02005	COG1113	amino acid transport
HA035_RS02015	COG0531	amino acid
HA035_RS02030	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HA035_RS02040	COG1174	glycine betaine transport
HA035_RS02050	COG1174	glycine betaine transport
HA035_RS02070	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
HA035_RS02075	COG0531	amino acid
HA035_RS02080	COG2272	Belongs to the type-B carboxylesterase lipase family
HA035_RS02085	COG2814	Major facilitator Superfamily
HA035_RS02090	COG0390	transport system, permease component
HA035_RS02095	COG4619	ABC transporter
HA035_RS02100	COG1363	Peptidase, m42
HA035_RS02115	COG4808	Protein conserved in bacteria
HA035_RS02120	COG0069	glutamate synthase activity
HA035_RS02135	COG1124	(ABC) transporter
HA035_RS02140	COG0444	Belongs to the ABC transporter superfamily
HA035_RS02145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HA035_RS02150	COG0601	transmembrane transport
HA035_RS02155	COG0747	negative chemotaxis
HA035_RS02185	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HA035_RS02190	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HA035_RS02275	COG0494	nUDIX hydrolase
HA035_RS02310	COG1846	Transcriptional regulator
HA035_RS02315	COG1846	Transcriptional regulator
HA035_RS02345	COG1070	Carbohydrate kinase
HA035_RS02350	COG1802	Transcriptional regulator
HA035_RS02355	COG0789	Transcriptional regulator
HA035_RS02360	COG2357	RelA SpoT domain protein
HA035_RS02365	COG4876	unkown
HA035_RS02375	COG2271	Major facilitator Superfamily
HA035_RS02380	COG0586	Pfam SNARE associated Golgi protein
HA035_RS02390	COG2814	Major facilitator Superfamily
HA035_RS02395	COG1846	Transcriptional regulator
HA035_RS02400	COG1131	(ABC) transporter
HA035_RS02415	COG3949	Membrane
HA035_RS02420	COG0400	carboxylic ester hydrolase activity
HA035_RS02425	COG0346	lactoylglutathione lyase activity
HA035_RS02430	COG1846	Transcriptional regulator
HA035_RS02440	COG2514	catechol 2,3-dioxygenase activity
HA035_RS02455	COG0561	phosphatase activity
HA035_RS02460	COG1131	(ABC) transporter
HA035_RS02470	COG3764	Sortase (surface protein transpeptidase)
HA035_RS02490	COG1760	l-serine dehydratase
HA035_RS02495	COG1760	l-serine dehydratase
HA035_RS02510	COG0697	spore germination
HA035_RS02515	COG0657	acetylesterase activity
HA035_RS02535	COG0028	Belongs to the TPP enzyme family
HA035_RS02550	COG0583	DNA-binding transcription factor activity
HA035_RS02560	COG3942	CHAP domain
HA035_RS02585	COG3425	synthase
HA035_RS02590	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HA035_RS02595	COG0542	response to heat
HA035_RS02615	COG2409	Drug exporters of the RND superfamily
HA035_RS02660	COG0436	Aminotransferase
HA035_RS02690	COG3942	CHAP domain
HA035_RS02695	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HA035_RS02695	COG2755	lipolytic protein G-D-S-L family
HA035_RS02765	COG0596	Alpha beta hydrolase
HA035_RS02800	COG3001	Fructosamine kinase
HA035_RS02805	COG0167	dihydroorotate dehydrogenase activity
HA035_RS02855	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HA035_RS02860	COG3527	Alpha-acetolactate decarboxylase
HA035_RS02870	COG0531	amino acid
HA035_RS02900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HA035_RS02920	COG1012	belongs to the aldehyde dehydrogenase family
HA035_RS02930	COG1510	regulation of RNA biosynthetic process
HA035_RS02940	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HA035_RS02965	COG2851	Citrate transporter
HA035_RS02980	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HA035_RS02990	COG0386	Belongs to the glutathione peroxidase family
HA035_RS03010	COG1136	(ABC) transporter
HA035_RS03015	COG2205	protein histidine kinase activity
HA035_RS03020	COG0745	RESPONSE REGULATOR receiver
HA035_RS03030	COG1785	Belongs to the alkaline phosphatase family
HA035_RS03085	COG1438	arginine binding
HA035_RS03110	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HA035_RS03110	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HA035_RS03110	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HA035_RS03115	COG1482	cell wall glycoprotein biosynthetic process
HA035_RS03125	COG1705	Flagellar rod assembly protein muramidase FlgJ
HA035_RS03125	COG3942	CHAP domain
HA035_RS03130	COG3433	isochorismatase activity
HA035_RS03130	COG1535	isochorismatase
HA035_RS03145	COG0438	transferase activity, transferring glycosyl groups
HA035_RS03160	COG1073	alpha beta
HA035_RS03180	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HA035_RS03200	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HA035_RS03255	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HA035_RS03290	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HA035_RS03375	COG0471	metal ion transport
HA035_RS03380	COG2962	Rard protein
HA035_RS03390	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HA035_RS03405	COG1136	(ABC) transporter
HA035_RS03410	COG0577	efflux transmembrane transporter activity
HA035_RS03445	COG1278	Cold shock
HA035_RS03465	COG1475	DNA binding
HA035_RS03505	COG2501	S4 domain
HA035_RS03525	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HA035_RS03550	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HA035_RS03560	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HA035_RS03570	COG0305	Participates in initiation and elongation during chromosome replication
HA035_RS03600	COG4863	YycH protein
HA035_RS03610	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HA035_RS03645	COG0584	glycerophosphoryl diester phosphodiesterase
HA035_RS03650	COG2030	dehydratase
HA035_RS03735	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HA035_RS03790	COG0730	response to heat
HA035_RS03795	COG1937	Protein conserved in bacteria
HA035_RS03800	COG2210	Belongs to the sulfur carrier protein TusA family
HA035_RS03805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HA035_RS03825	COG3682	Transcriptional regulator
HA035_RS03890	COG0583	DNA-binding transcription factor activity
HA035_RS03910	COG0823	Involved in the tonB-independent uptake of proteins
HA035_RS03935	COG1473	amidohydrolase
HA035_RS03945	COG1283	sodium-dependent phosphate transmembrane transporter activity
HA035_RS03950	COG4716	Myosin-crossreactive antigen
HA035_RS03955	COG0697	spore germination
HA035_RS03970	COG1620	l-lactate permease
HA035_RS03985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HA035_RS03990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HA035_RS03995	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HA035_RS04005	COG2423	ornithine cyclodeaminase activity
HA035_RS04010	COG4264	IucA IucC family
HA035_RS04015	COG2814	Major facilitator Superfamily
HA035_RS04020	COG4264	IucA IucC family
HA035_RS04025	COG4264	IucA IucC family
HA035_RS04035	COG0019	diaminopimelate decarboxylase activity
HA035_RS04040	COG1475	DNA binding
HA035_RS04065	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HA035_RS04070	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HA035_RS04075	COG0438	transferase activity, transferring glycosyl groups
HA035_RS04105	COG0813	purine-nucleoside phosphorylase activity
HA035_RS04110	COG2814	Major facilitator Superfamily
HA035_RS04130	COG3639	organic phosphonate transmembrane transporter activity
HA035_RS04150	COG0737	Belongs to the 5'-nucleotidase family
HA035_RS04180	COG1454	alcohol dehydrogenase
HA035_RS04180	COG1012	belongs to the aldehyde dehydrogenase family
HA035_RS04215	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HA035_RS04245	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HA035_RS04255	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HA035_RS04260	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HA035_RS04270	COG2832	Protein of unknown function (DUF454)
HA035_RS04305	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HA035_RS04310	COG1960	acyl-CoA dehydrogenase activity
HA035_RS04315	COG5609	conserved protein (DUF2294)
HA035_RS04365	COG1114	Component of the transport system for branched-chain amino acids
HA035_RS04370	COG1335	isochorismatase
HA035_RS04375	COG3961	Belongs to the TPP enzyme family
HA035_RS04405	COG1737	Transcriptional regulator
HA035_RS04445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HA035_RS04455	COG0405	Gamma-glutamyltransferase
HA035_RS04495	COG3842	ATPase activity
HA035_RS04505	COG1175	transmembrane transport
HA035_RS04510	COG3833	ABC-type maltose transport systems, permease component
HA035_RS04515	COG0673	inositol 2-dehydrogenase activity
HA035_RS04520	COG0673	inositol 2-dehydrogenase activity
HA035_RS04530	COG1755	Isoprenylcysteine carboxyl methyltransferase
HA035_RS04585	COG0183	Belongs to the thiolase family
HA035_RS04595	COG1960	acyl-CoA dehydrogenase activity
HA035_RS04600	COG0318	PFAM AMP-dependent synthetase and ligase
HA035_RS04615	COG0747	negative chemotaxis
HA035_RS04620	COG3189	MarR family transcriptional regulator
HA035_RS04645	COG1263	PTS System
HA035_RS04645	COG2190	(PTS) system
HA035_RS04645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HA035_RS04650	COG1957	nucleoside hydrolase
HA035_RS04670	COG3414	Phosphotransferase system galactitol-specific IIB component
HA035_RS04675	COG3775	system Galactitol-specific IIC component
HA035_RS04680	COG1063	alcohol dehydrogenase
HA035_RS04690	COG1063	alcohol dehydrogenase
HA035_RS04700	COG1063	alcohol dehydrogenase
HA035_RS04705	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HA035_RS04710	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HA035_RS04720	COG1063	alcohol dehydrogenase
HA035_RS04725	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HA035_RS04760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HA035_RS04765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HA035_RS04765	COG1263	PTS System
HA035_RS04765	COG2190	(PTS) system
HA035_RS04770	COG2723	6-phospho-beta-galactosidase activity
HA035_RS04775	COG2226	methyltransferase
HA035_RS04835	COG1131	(ABC) transporter
HA035_RS04865	COG3942	CHAP domain
HA035_RS04865	COG1388	LysM domain
HA035_RS05000	COG1114	Component of the transport system for branched-chain amino acids
HA035_RS05005	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HA035_RS05010	COG0577	efflux transmembrane transporter activity
HA035_RS05035	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HA035_RS05040	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HA035_RS05090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HA035_RS05120	COG3037	sugar-specific permease SgaT UlaA
HA035_RS05130	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HA035_RS05135	COG3711	transcriptional antiterminator
HA035_RS05155	COG2271	Major facilitator Superfamily
HA035_RS05160	COG0346	lactoylglutathione lyase activity
HA035_RS05165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HA035_RS05170	COG0431	NADPH-dependent FMN reductase
HA035_RS05185	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HA035_RS05190	COG2822	iron ion transport
HA035_RS05200	COG0672	)-iron permease
HA035_RS05205	COG0805	protein transport
HA035_RS05210	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HA035_RS05220	COG1476	TRANSCRIPTIONal
HA035_RS05230	COG1131	(ABC) transporter
HA035_RS05260	COG0646	methionine synthase
HA035_RS05260	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HA035_RS05265	COG0626	cystathionine gamma-synthase activity
HA035_RS05270	COG0626	cystathionine gamma-synthase activity
HA035_RS05275	COG1475	DNA binding
HA035_RS05280	COG0668	transmembrane transport
HA035_RS05285	COG4481	Protein conserved in bacteria
HA035_RS05290	COG0012	GTP binding
HA035_RS05375	COG3634	alkyl hydroperoxide reductase activity
HA035_RS05390	COG1823	symporter activity
HA035_RS05420	COG2233	PERMEase
HA035_RS05455	COG3759	membrane
HA035_RS05610	COG0523	cobalamin synthesis protein
HA035_RS05635	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HA035_RS05645	COG5609	conserved protein (DUF2294)
HA035_RS05660	COG1647	Serine aminopeptidase, S33
HA035_RS05670	COG0733	neurotransmitter:sodium symporter activity
HA035_RS05675	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HA035_RS05680	COG0626	cystathionine gamma-synthase activity
HA035_RS05690	COG2011	ABC-type metal ion transport system permease component
HA035_RS05695	COG1464	Belongs to the NlpA lipoprotein family
HA035_RS05730	COG0583	DNA-binding transcription factor activity
HA035_RS05735	COG0069	glutamate synthase activity
HA035_RS05735	COG0067	glutamate synthase
HA035_RS05735	COG0070	glutamate synthase
HA035_RS05740	COG0493	'glutamate synthase
HA035_RS05750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HA035_RS05750	COG1263	PTS System
HA035_RS05755	COG0366	Alpha amylase catalytic
HA035_RS05760	COG2188	Transcriptional regulator
HA035_RS05780	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HA035_RS05815	COG1982	Orn Lys Arg decarboxylase major
HA035_RS05825	COG3870	Protein conserved in bacteria
HA035_RS05830	COG0470	DNA polymerase III
HA035_RS05835	COG1774	PSP1 C-terminal conserved region
HA035_RS05845	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HA035_RS05855	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HA035_RS05865	COG0084	hydrolase, TatD family'
HA035_RS05870	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HA035_RS05880	COG4466	Protein conserved in bacteria
HA035_RS05890	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HA035_RS05895	COG0251	oxidation-reduction process
HA035_RS05935	COG2244	polysaccharide biosynthetic process
HA035_RS05940	COG3956	TIGRFAM MazG family protein
HA035_RS05945	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HA035_RS05955	COG1098	S1 RNA binding domain
HA035_RS05970	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HA035_RS05995	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HA035_RS06090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HA035_RS06105	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HA035_RS06115	COG3880	PFAM UvrB UvrC protein
HA035_RS06130	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HA035_RS06135	COG4956	integral membrane protein (PIN domain superfamily)
HA035_RS06155	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HA035_RS06210	COG2813	Specifically methylates the guanine in position
HA035_RS06250	COG1473	amidohydrolase
HA035_RS06280	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HA035_RS06285	COG1428	Deoxynucleoside kinase
HA035_RS06290	COG1428	Deoxynucleoside kinase
HA035_RS06300	COG0561	phosphatase activity
HA035_RS06340	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HA035_RS06355	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HA035_RS06445	COG0095	Lipoate-protein ligase
HA035_RS06450	COG0083	homoserine kinase activity
HA035_RS06470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HA035_RS06555	COG0667	Aldo Keto reductase
HA035_RS06560	COG0655	NAD(P)H dehydrogenase (quinone) activity
HA035_RS06570	COG1078	dGTPase activity
HA035_RS06605	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HA035_RS06610	COG4139	cobalamin transport
HA035_RS06660	COG4974	Belongs to the 'phage' integrase family
HA035_RS06705	COG0803	Belongs to the bacterial solute-binding protein 9 family
HA035_RS06710	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HA035_RS06715	COG1121	(ABC) transporter
HA035_RS06720	COG1321	iron dependent repressor
HA035_RS06730	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HA035_RS06740	COG1682	transport, permease protein
HA035_RS06745	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HA035_RS06750	COG1216	Glycosyl transferase, family 2
HA035_RS06755	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HA035_RS06760	COG1686	Belongs to the peptidase S11 family
HA035_RS06765	COG1132	(ABC) transporter
HA035_RS06770	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HA035_RS06780	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HA035_RS06785	COG1120	ATPase activity
HA035_RS06790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HA035_RS06795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HA035_RS06800	COG2376	Dihydroxyacetone kinase
HA035_RS06810	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HA035_RS06820	COG3949	Membrane
HA035_RS06840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HA035_RS06855	COG1136	(ABC) transporter
HA035_RS06860	COG0577	efflux transmembrane transporter activity
HA035_RS06865	COG1392	Phosphate transport regulator
HA035_RS06870	COG0306	phosphate transporter
HA035_RS06875	COG1388	LysM domain
HA035_RS06875	COG3942	CHAP domain
HA035_RS06885	COG1917	Cupin 2, conserved barrel domain protein
HA035_RS06885	COG4977	sequence-specific DNA binding
HA035_RS06915	COG0583	DNA-binding transcription factor activity
HA035_RS06920	COG2814	Major facilitator Superfamily
HA035_RS06925	COG2839	Protein conserved in bacteria
HA035_RS06955	COG1611	Belongs to the LOG family
HA035_RS06975	COG4988	ABC transporter
HA035_RS06980	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HA035_RS06990	COG0523	cobalamin synthesis protein
HA035_RS06995	COG4989	oxidoreductase activity
HA035_RS07005	COG0471	metal ion transport
HA035_RS07040	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HA035_RS07045	COG1349	DNA-binding transcription factor activity
HA035_RS07050	COG1105	Belongs to the carbohydrate kinase PfkB family
HA035_RS07055	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HA035_RS07055	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HA035_RS07055	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HA035_RS07060	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HA035_RS07065	COG1253	flavin adenine dinucleotide binding
HA035_RS07070	COG0656	L-ascorbic acid biosynthetic process
HA035_RS07075	COG0463	Glycosyl transferase, family 2
HA035_RS07110	COG0720	synthase
HA035_RS07120	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HA035_RS07120	COG0512	Glutamine amidotransferase of anthranilate synthase
HA035_RS07125	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HA035_RS07155	COG0488	(ABC) transporter
HA035_RS07160	COG0514	ATP-dependent DNA helicase (RecQ)
HA035_RS07165	COG1125	glycine betaine transport
HA035_RS07165	COG0517	IMP dehydrogenase activity
HA035_RS07170	COG1174	glycine betaine transport
HA035_RS07195	COG3104	oligopeptide transport
HA035_RS07215	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HA035_RS07220	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HA035_RS07230	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HA035_RS07235	COG4605	iron ion homeostasis
HA035_RS07240	COG4604	ABC transporter, ATP-binding protein
HA035_RS07245	COG4607	ABC-type enterochelin transport system periplasmic component
HA035_RS07300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HA035_RS07305	COG1739	Uncharacterized protein family UPF0029
HA035_RS07315	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HA035_RS07320	COG1040	competence protein
HA035_RS07350	COG1388	LysM domain
HA035_RS07350	COG3942	CHAP domain
HA035_RS07405	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HA035_RS07465	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HA035_RS07470	COG1647	Serine aminopeptidase, S33
HA035_RS07475	COG0557	exoribonuclease II activity
HA035_RS07545	COG1278	Cold shock
HA035_RS07585	COG0406	alpha-ribazole phosphatase activity
HA035_RS07590	COG1279	arginine transmembrane transporter activity
HA035_RS07615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HA035_RS07620	COG1393	Belongs to the ArsC family
HA035_RS07630	COG3878	Protein conserved in bacteria
HA035_RS07635	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HA035_RS07650	COG2011	ABC-type metal ion transport system permease component
HA035_RS07655	COG1464	Belongs to the NlpA lipoprotein family
HA035_RS07670	COG0396	ATPase activity
HA035_RS07675	COG0719	Fe-S assembly protein
HA035_RS07685	COG0822	iron-sulfur transferase activity
HA035_RS07705	COG1253	flavin adenine dinucleotide binding
HA035_RS07720	COG1801	Protein of unknown function DUF72
HA035_RS07725	COG0730	response to heat
HA035_RS07740	COG4470	Protein conserved in bacteria
HA035_RS07750	COG2445	Protein of unknown function DUF86
HA035_RS07780	COG1696	Membrane protein involved in D-alanine export
HA035_RS07790	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HA035_RS07795	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HA035_RS07800	COG4837	Protein of unknown function (DUF1462)
HA035_RS07805	COG1252	NADH dehydrogenase
HA035_RS07815	COG0316	Belongs to the HesB IscA family
HA035_RS07825	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HA035_RS07830	COG2056	Na+-H+ antiporter family
HA035_RS07890	COG1098	S1 RNA binding domain
HA035_RS07895	COG1902	pentaerythritol trinitrate reductase activity
HA035_RS07910	COG0584	glycerophosphoryl diester phosphodiesterase
HA035_RS07930	COG0398	Pfam SNARE associated Golgi protein
HA035_RS07970	COG0561	phosphatase activity
HA035_RS07995	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HA035_RS08010	COG1881	PFAM PEBP family protein
HA035_RS08040	COG0601	transmembrane transport
HA035_RS08045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HA035_RS08050	COG0444	Belongs to the ABC transporter superfamily
HA035_RS08055	COG4608	Belongs to the ABC transporter superfamily
HA035_RS08060	COG4166	transmembrane transport
HA035_RS08065	COG0747	negative chemotaxis
HA035_RS08070	COG0444	Belongs to the ABC transporter superfamily
HA035_RS08075	COG4608	Belongs to the ABC transporter superfamily
HA035_RS08080	COG0601	transmembrane transport
HA035_RS08085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HA035_RS08110	COG1164	Oligoendopeptidase f
HA035_RS08120	COG2346	COG2346, Truncated hemoglobins
HA035_RS08135	COG2357	RelA SpoT domain protein
HA035_RS08145	COG0564	pseudouridine synthase activity
HA035_RS08150	COG2239	Acts as a magnesium transporter
HA035_RS08155	COG0475	glutathione-regulated potassium exporter activity
HA035_RS08155	COG0569	domain protein
HA035_RS08165	COG0628	permease
HA035_RS08170	COG1115	amino acid carrier protein
HA035_RS08210	COG0861	Integral membrane protein TerC family
HA035_RS08220	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HA035_RS08225	COG0737	Belongs to the 5'-nucleotidase family
HA035_RS08240	COG4903	ComK protein
HA035_RS08255	COG4873	Protein conserved in bacteria
HA035_RS08315	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HA035_RS08325	COG2314	TM2 domain
HA035_RS08330	COG0456	acetyltransferase
HA035_RS08335	COG1575	Belongs to the MenA family. Type 1 subfamily
HA035_RS08340	COG1169	isochorismate synthase
HA035_RS08350	COG2267	carboxylic ester hydrolase activity
HA035_RS08375	COG0436	Aminotransferase
HA035_RS08380	COG3594	Acyltransferase
HA035_RS08410	COG1316	TRANSCRIPTIONal
HA035_RS08415	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HA035_RS08455	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HA035_RS08470	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HA035_RS08500	COG0138	bifunctional purine biosynthesis protein purh
HA035_RS08510	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HA035_RS08515	COG4172	Belongs to the ABC transporter superfamily
HA035_RS08520	COG4721	ABC-type cobalt transport system, permease component
HA035_RS08535	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HA035_RS08560	COG1271	oxidase subunit
HA035_RS08565	COG1294	oxidase, subunit
HA035_RS08570	COG0569	domain protein
HA035_RS08635	COG1176	ABC-type spermidine putrescine transport system, permease component I
HA035_RS08640	COG1177	transmembrane transport
HA035_RS08645	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HA035_RS08670	COG0483	inositol monophosphate 1-phosphatase activity
HA035_RS08690	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HA035_RS08700	COG0772	Belongs to the SEDS family
HA035_RS08730	COG3679	Belongs to the UPF0342 family
HA035_RS08750	COG0742	ribosomal rna small subunit methyltransferase
HA035_RS08805	COG4509	Sortase family
HA035_RS08820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HA035_RS08850	COG1796	DNA polymerase
HA035_RS08850	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HA035_RS08875	COG2009	succinate dehydrogenase
HA035_RS08880	COG1053	succinate dehydrogenase
HA035_RS08885	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HA035_RS08990	COG1288	antiporter activity
HA035_RS09025	COG1011	Hydrolase
HA035_RS09050	COG4839	cell division protein FtsL
HA035_RS09070	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HA035_RS09075	COG0849	cell division
HA035_RS09090	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HA035_RS09100	COG0762	integral membrane protein
HA035_RS09105	COG2302	S4 RNA-binding domain
HA035_RS09110	COG3599	regulation of cell shape
HA035_RS09120	COG2514	catechol 2,3-dioxygenase activity
HA035_RS09135	COG0564	pseudouridine synthase activity
HA035_RS09145	COG2233	PERMEase
HA035_RS09190	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HA035_RS09205	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HA035_RS09210	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HA035_RS09220	COG2314	TM2 domain
HA035_RS09235	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HA035_RS09235	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HA035_RS09245	COG0631	protein serine/threonine phosphatase activity
HA035_RS09260	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HA035_RS09275	COG1302	Protein conserved in bacteria
HA035_RS09285	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HA035_RS09320	COG1196	nuclear chromosome segregation
HA035_RS09325	COG0552	protein localization to endoplasmic reticulum
HA035_RS09335	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HA035_RS09490	COG0195	Participates in both transcription termination and antitermination
HA035_RS09495	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HA035_RS09520	COG0196	riboflavin kinase activity
HA035_RS09545	COG2188	Transcriptional regulator
HA035_RS09550	COG0612	Peptidase, M16
HA035_RS09555	COG0612	Peptidase, M16
HA035_RS09560	COG0300	oxidoreductase activity
HA035_RS09580	COG1546	Belongs to the CinA family
HA035_RS09580	COG1058	Belongs to the CinA family
HA035_RS09600	COG1692	metallophosphoesterase
HA035_RS09605	COG0674	pyruvate-flavodoxin oxidoreductase activity
HA035_RS09605	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HA035_RS09610	COG1013	pyruvate-flavodoxin oxidoreductase activity
HA035_RS09645	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HA035_RS09650	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HA035_RS09675	COG1923	regulation of RNA biosynthetic process
HA035_RS09690	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HA035_RS09695	COG0789	Transcriptional regulator
HA035_RS09805	COG1131	(ABC) transporter
HA035_RS09820	COG2197	response regulator
HA035_RS09830	COG1525	nuclease
HA035_RS09845	COG0527	aspartate kinase activity
HA035_RS09850	COG0460	homoserine dehydrogenase
HA035_RS09855	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HA035_RS09880	COG0833	amino acid
HA035_RS09905	COG2340	Cysteine-rich secretory protein family
HA035_RS09940	COG4846	Membrane protein involved in cytochrome C biogenesis
HA035_RS09960	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HA035_RS09970	COG0824	Thioesterase
HA035_RS09995	COG1115	amino acid carrier protein
HA035_RS10010	COG0628	permease
HA035_RS10015	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HA035_RS10015	COG0392	lysyltransferase activity
HA035_RS10035	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HA035_RS10045	COG1363	Peptidase, m42
HA035_RS10050	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HA035_RS10055	COG0512	Glutamine amidotransferase of anthranilate synthase
HA035_RS10095	COG0561	phosphatase activity
HA035_RS10140	COG0704	Plays a role in the regulation of phosphate uptake
HA035_RS10150	COG0581	inorganic phosphate transmembrane transporter activity
HA035_RS10155	COG0573	inorganic phosphate transmembrane transporter activity
HA035_RS10175	COG0488	(ABC) transporter
HA035_RS10180	COG0527	aspartate kinase activity
HA035_RS10185	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HA035_RS10260	COG4548	von Willebrand factor, type A
HA035_RS10265	COG0714	Associated with various cellular activities
HA035_RS10315	COG0671	phosphoesterase, PA-phosphatase related
HA035_RS10375	COG1413	lyase activity
HA035_RS10390	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HA035_RS10410	COG0531	amino acid
HA035_RS10425	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HA035_RS10430	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HA035_RS10445	COG0116	Belongs to the methyltransferase superfamily
HA035_RS10480	COG4499	WXG100 protein secretion system (Wss), protein YukC
HA035_RS10480	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HA035_RS10490	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HA035_RS10495	COG3935	DnaD domain protein
HA035_RS10520	COG0438	transferase activity, transferring glycosyl groups
HA035_RS10525	COG1694	Mazg nucleotide pyrophosphohydrolase
HA035_RS10530	COG2738	Putative neutral zinc metallopeptidase
HA035_RS10535	COG4347	Protein of unknown function (DUF1405)
HA035_RS10575	COG0142	geranyltranstransferase activity
HA035_RS10630	COG0492	ferredoxin-NADP+ reductase activity
HA035_RS10645	COG0514	ATP-dependent DNA helicase (RecQ)
HA035_RS10655	COG1141	Ferredoxin
HA035_RS10695	COG1388	LysM domain
HA035_RS10695	COG0860	N-Acetylmuramoyl-L-alanine amidase
HA035_RS10745	COG3953	SLT domain
HA035_RS10745	COG5280	Phage tail tape measure protein TP901
HA035_RS10865	COG0756	dUTP diphosphatase activity
HA035_RS11010	COG0582	viral genome integration into host DNA
HA035_RS11025	COG5002	protein histidine kinase activity
HA035_RS11030	COG0745	RESPONSE REGULATOR receiver
HA035_RS11035	COG1187	pseudouridine synthase activity
HA035_RS11060	COG0735	belongs to the Fur family
HA035_RS11065	COG0494	nUDIX hydrolase
HA035_RS11070	COG0667	Aldo Keto reductase
HA035_RS11080	COG4221	oxidoreductase activity
HA035_RS11095	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HA035_RS11105	COG0366	Alpha amylase catalytic
HA035_RS11110	COG1609	Transcriptional regulator
HA035_RS11130	COG2195	Cleaves the N-terminal amino acid of tripeptides
HA035_RS11140	COG4129	membrane
HA035_RS11150	COG0508	dehydrogenase complex catalyzes the overall conversion of
HA035_RS11155	COG0022	dehydrogenase e1 component
HA035_RS11160	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HA035_RS11165	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HA035_RS11170	COG0497	DNA recombination
HA035_RS11200	COG1302	Protein conserved in bacteria
HA035_RS11205	COG0439	Biotin carboxylase
HA035_RS11210	COG0511	ligase activity, forming carbon-carbon bonds
HA035_RS11220	COG0006	proline dipeptidase activity
HA035_RS11235	COG0095	Lipoate-protein ligase
HA035_RS11240	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HA035_RS11285	COG4537	Required for transformation and DNA binding
HA035_RS11290	COG1459	type II secretion system
HA035_RS11295	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HA035_RS11300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HA035_RS11305	COG0011	TIGRFAM Protein of
HA035_RS11310	COG1940	carbohydrate kinase activity
HA035_RS11315	COG4483	Protein conserved in bacteria
HA035_RS11325	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HA035_RS11350	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HA035_RS11355	COG1121	(ABC) transporter
HA035_RS11365	COG0513	Belongs to the DEAD box helicase family
HA035_RS11375	COG2384	SAM-dependent methyltransferase
HA035_RS11395	COG0517	IMP dehydrogenase activity
HA035_RS11415	COG0295	cytidine deaminase activity
HA035_RS11430	COG1702	phosphate starvation-inducible protein PhoH
HA035_RS11445	COG1030	water channel activity
HA035_RS11455	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HA035_RS11460	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HA035_RS11490	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HA035_RS11505	COG1466	dna polymerase III delta subunit
HA035_RS11510	COG0658	competence protein
HA035_RS11510	COG2333	competence protein COMEC
HA035_RS11515	COG2131	deaminase
HA035_RS11525	COG2226	methyltransferase
HA035_RS11530	COG0799	negative regulation of ribosome biogenesis
HA035_RS11535	COG1713	HD superfamily hydrolase involved in NAD metabolism
HA035_RS11545	COG1534	Rna-binding protein
HA035_RS11555	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HA035_RS11560	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HA035_RS11580	COG3177	Filamentation induced by cAMP protein fic
HA035_RS11585	COG1914	H( )-stimulated, divalent metal cation uptake system
HA035_RS11595	COG0439	Biotin carboxylase
HA035_RS11600	COG0511	ligase activity, forming carbon-carbon bonds
HA035_RS11605	COG1984	allophanate hydrolase subunit 2
HA035_RS11610	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HA035_RS11660	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HA035_RS11675	COG1104	cysteine desulfurase activity
HA035_RS11680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HA035_RS11695	COG1959	2 iron, 2 sulfur cluster binding
HA035_RS11700	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HA035_RS11705	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HA035_RS11750	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HA035_RS11750	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HA035_RS11755	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HA035_RS11755	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HA035_RS11760	COG1862	Preprotein translocase
HA035_RS11800	COG2868	ribosomal protein
HA035_RS11845	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HA035_RS11850	COG0285	dihydrofolate synthase activity
HA035_RS11860	COG2818	Glycosylase
HA035_RS11895	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HA035_RS11930	COG4112	unkown
HA035_RS11950	COG0833	amino acid
HA035_RS11965	COG1484	DNA-dependent DNA replication
HA035_RS11995	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HA035_RS11995	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HA035_RS12005	COG5002	protein histidine kinase activity
HA035_RS12010	COG0745	RESPONSE REGULATOR receiver
HA035_RS12020	COG0372	Belongs to the citrate synthase family
HA035_RS12025	COG1113	amino acid transport
HA035_RS12055	COG0281	malic enzyme
HA035_RS12065	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HA035_RS12070	COG4109	DRTGG domain
HA035_RS12110	COG0827	DNA restriction-modification system
HA035_RS12130	COG1104	cysteine desulfurase activity
HA035_RS12145	COG1956	GAF domain-containing protein
HA035_RS12155	COG0584	glycerophosphoryl diester phosphodiesterase
HA035_RS12160	COG1764	response to oxidative stress
HA035_RS12165	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HA035_RS12170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HA035_RS12185	COG1263	PTS System
HA035_RS12185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HA035_RS12190	COG0204	Acyl-transferase
HA035_RS12195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HA035_RS12230	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HA035_RS12235	COG0454	-acetyltransferase
HA035_RS12255	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HA035_RS12255	COG1605	Chorismate mutase
HA035_RS12280	COG1674	ftsk spoiiie
HA035_RS12285	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HA035_RS12295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HA035_RS12300	COG1363	Peptidase, m42
HA035_RS12310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HA035_RS12320	COG0510	thiamine kinase activity
HA035_RS12340	COG1187	pseudouridine synthase activity
HA035_RS12345	COG2244	polysaccharide biosynthetic process
HA035_RS12350	COG2081	HI0933 family
HA035_RS12370	COG2814	Major facilitator Superfamily
HA035_RS12375	COG1242	4 iron, 4 sulfur cluster binding
HA035_RS12380	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HA035_RS12395	COG2267	carboxylic ester hydrolase activity
HA035_RS12425	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HA035_RS12425	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HA035_RS12450	COG5632	N-Acetylmuramoyl-L-alanine amidase
HA035_RS12450	COG4193	domain, Protein
HA035_RS12450	COG3266	domain, Protein
HA035_RS12480	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HA035_RS12505	COG0656	L-ascorbic acid biosynthetic process
HA035_RS12530	COG1506	peptidase
HA035_RS12705	COG1131	(ABC) transporter
HA035_RS12840	COG1131	(ABC) transporter
HA035_RS12845	COG0537	adenosine 5'-monophosphoramidase activity
HA035_RS12875	COG0420	3'-5' exonuclease activity
HA035_RS12900	COG2197	response regulator
HA035_RS12905	COG4585	Histidine kinase
HA035_RS12905	COG2203	Gaf domain
HA035_RS12910	COG0564	pseudouridine synthase activity
HA035_RS12940	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HA035_RS12945	COG1126	abc transporter atp-binding protein
HA035_RS12950	COG0765	amino acid transport
HA035_RS13125	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HA035_RS13130	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HA035_RS13140	COG4129	membrane
HA035_RS13165	COG1988	membrane-bound metal-dependent
HA035_RS13175	COG1134	teichoic acid transport
HA035_RS13175	COG1388	LysM domain
HA035_RS13205	COG0535	radical SAM domain protein
HA035_RS13210	COG1607	acyl-coa hydrolase
HA035_RS13215	COG2309	aminopeptidase activity
HA035_RS13235	COG1295	ribonuclease BN
HA035_RS13240	COG2197	response regulator
HA035_RS13350	COG4851	CamS sex pheromone cAM373 precursor
HA035_RS13360	COG0210	DNA helicase
HA035_RS13370	COG4496	protein, YerC YecD
HA035_RS13405	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HA035_RS13415	COG0077	Prephenate dehydratase
HA035_RS13440	COG1388	LysM domain
HA035_RS13440	COG5632	N-Acetylmuramoyl-L-alanine amidase
HA035_RS13570	COG1783	phage Terminase large subunit
HA035_RS13665	COG1484	DNA-dependent DNA replication
HA035_RS13750	COG1335	isochorismatase
HA035_RS13765	COG1012	belongs to the aldehyde dehydrogenase family
HA035_RS13820	COG1131	(ABC) transporter
HA035_RS13835	COG1725	Transcriptional regulator
HA035_RS13895	COG5632	N-Acetylmuramoyl-L-alanine amidase
HA035_RS13895	COG1388	LysM domain
HA035_RS13945	COG0739	heme binding
HA035_RS14000	COG0740	serine-type endopeptidase activity
HA035_RS14215	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HA035_RS14220	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HA035_RS14225	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HA035_RS14240	COG3728	DNA packaging
HA035_RS14240	COG5484	DNA packaging
HA035_RS14315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HA035_RS14320	COG1621	beta-fructofuranosidase activity
HA035_RS14325	COG1609	Transcriptional regulator
HA035_RS14330	COG0004	ammonium transporteR
HA035_RS14335	COG0425	Belongs to the sulfur carrier protein TusA family
HA035_RS14340	COG2391	methyltransferase activity
HA035_RS14350	COG0488	(ABC) transporter
HA035_RS14360	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HA035_RS14370	COG0456	acetyltransferase
HA035_RS14375	COG1214	PFAM Peptidase M22, glycoprotease
HA035_RS14380	COG0802	atpase or kinase
HA035_RS14395	COG0028	Belongs to the TPP enzyme family
HA035_RS14510	COG3093	addiction module antidote protein HigA
HA035_RS14525	COG3173	Aminoglycoside phosphotransferase
HA035_RS14560	COG1968	undecaprenyl-diphosphatase activity
HA035_RS14575	COG0456	acetyltransferase
HA035_RS14600	COG3682	Transcriptional regulator
HA035_RS14620	COG0604	alcohol dehydrogenase
HA035_RS14670	COG3093	addiction module antidote protein HigA
HA035_RS14685	COG3173	Aminoglycoside phosphotransferase
HA035_RS14720	COG1968	undecaprenyl-diphosphatase activity
HA035_RS14735	COG0456	acetyltransferase
HA035_RS14765	COG3682	Transcriptional regulator