locus-tag	class	description
A7U46_RS00005	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A7U46_RS00025	COG4846	Membrane protein involved in cytochrome C biogenesis
A7U46_RS00060	COG2340	Cysteine-rich secretory protein family
A7U46_RS00090	COG0833	amino acid
A7U46_RS00115	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A7U46_RS00120	COG0460	homoserine dehydrogenase
A7U46_RS00125	COG0527	aspartate kinase activity
A7U46_RS00140	COG1525	nuclease
A7U46_RS00150	COG2197	response regulator
A7U46_RS00165	COG1131	(ABC) transporter
A7U46_RS00285	COG0789	Transcriptional regulator
A7U46_RS00290	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
A7U46_RS00295	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A7U46_RS00305	COG1923	regulation of RNA biosynthetic process
A7U46_RS00330	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A7U46_RS00335	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
A7U46_RS00370	COG1013	pyruvate-flavodoxin oxidoreductase activity
A7U46_RS00375	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A7U46_RS00375	COG0674	pyruvate-flavodoxin oxidoreductase activity
A7U46_RS00380	COG1692	metallophosphoesterase
A7U46_RS00400	COG1058	Belongs to the CinA family
A7U46_RS00400	COG1546	Belongs to the CinA family
A7U46_RS00420	COG0300	oxidoreductase activity
A7U46_RS00425	COG0612	Peptidase, M16
A7U46_RS00430	COG0612	Peptidase, M16
A7U46_RS00435	COG2188	Transcriptional regulator
A7U46_RS00465	COG0196	riboflavin kinase activity
A7U46_RS00490	COG2740	Nucleic-acid-binding protein implicated in transcription termination
A7U46_RS00495	COG0195	Participates in both transcription termination and antitermination
A7U46_RS00595	COG0758	DNA mediated transformation
A7U46_RS00655	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A7U46_RS00665	COG0552	protein localization to endoplasmic reticulum
A7U46_RS00670	COG1196	nuclear chromosome segregation
A7U46_RS00710	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A7U46_RS00720	COG1302	Protein conserved in bacteria
A7U46_RS00735	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A7U46_RS00750	COG0631	protein serine/threonine phosphatase activity
A7U46_RS00760	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A7U46_RS00760	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A7U46_RS00775	COG2314	TM2 domain
A7U46_RS00785	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A7U46_RS00790	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A7U46_RS00805	COG1293	RNA-binding protein homologous to eukaryotic snRNP
A7U46_RS00850	COG2233	PERMEase
A7U46_RS00860	COG0564	pseudouridine synthase activity
A7U46_RS00880	COG2514	catechol 2,3-dioxygenase activity
A7U46_RS00890	COG3599	regulation of cell shape
A7U46_RS00895	COG2302	S4 RNA-binding domain
A7U46_RS00900	COG0762	integral membrane protein
A7U46_RS00910	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A7U46_RS00925	COG0849	cell division
A7U46_RS00930	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A7U46_RS00945	COG0768	penicillin binding
A7U46_RS00950	COG4839	cell division protein FtsL
A7U46_RS00975	COG1011	Hydrolase
A7U46_RS01010	COG1288	antiporter activity
A7U46_RS01125	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A7U46_RS01130	COG1053	succinate dehydrogenase
A7U46_RS01135	COG2009	succinate dehydrogenase
A7U46_RS01160	COG1796	DNA polymerase
A7U46_RS01160	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A7U46_RS01195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A7U46_RS01210	COG4509	Sortase family
A7U46_RS01270	COG0742	ribosomal rna small subunit methyltransferase
A7U46_RS01290	COG3679	Belongs to the UPF0342 family
A7U46_RS01325	COG0772	Belongs to the SEDS family
A7U46_RS01335	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A7U46_RS01345	COG1217	gtp-binding protein TYPA
A7U46_RS01355	COG0483	inositol monophosphate 1-phosphatase activity
A7U46_RS01380	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A7U46_RS01385	COG1177	transmembrane transport
A7U46_RS01390	COG1176	ABC-type spermidine putrescine transport system, permease component I
A7U46_RS01455	COG0569	domain protein
A7U46_RS01460	COG1294	oxidase, subunit
A7U46_RS01465	COG1271	oxidase subunit
A7U46_RS01490	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A7U46_RS01515	COG4721	ABC-type cobalt transport system, permease component
A7U46_RS01520	COG4172	Belongs to the ABC transporter superfamily
A7U46_RS01525	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A7U46_RS01565	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A7U46_RS01580	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A7U46_RS01625	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A7U46_RS01630	COG1316	TRANSCRIPTIONal
A7U46_RS01660	COG3594	Acyltransferase
A7U46_RS01665	COG0436	Aminotransferase
A7U46_RS01690	COG2267	carboxylic ester hydrolase activity
A7U46_RS01700	COG1169	isochorismate synthase
A7U46_RS01710	COG1575	Belongs to the MenA family. Type 1 subfamily
A7U46_RS01715	COG0456	acetyltransferase
A7U46_RS01720	COG2314	TM2 domain
A7U46_RS01730	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
A7U46_RS01790	COG4873	Protein conserved in bacteria
A7U46_RS01805	COG4903	ComK protein
A7U46_RS01820	COG0737	Belongs to the 5'-nucleotidase family
A7U46_RS01825	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A7U46_RS01835	COG0861	Integral membrane protein TerC family
A7U46_RS01875	COG1115	amino acid carrier protein
A7U46_RS01880	COG0628	permease
A7U46_RS01890	COG0475	glutathione-regulated potassium exporter activity
A7U46_RS01890	COG0569	domain protein
A7U46_RS01895	COG2239	Acts as a magnesium transporter
A7U46_RS01900	COG0564	pseudouridine synthase activity
A7U46_RS01910	COG2357	RelA SpoT domain protein
A7U46_RS01925	COG2346	COG2346, Truncated hemoglobins
A7U46_RS01935	COG1164	Oligoendopeptidase f
A7U46_RS01965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7U46_RS01970	COG0601	transmembrane transport
A7U46_RS01975	COG4608	Belongs to the ABC transporter superfamily
A7U46_RS01980	COG0444	Belongs to the ABC transporter superfamily
A7U46_RS01985	COG0747	negative chemotaxis
A7U46_RS01990	COG4166	transmembrane transport
A7U46_RS01995	COG4608	Belongs to the ABC transporter superfamily
A7U46_RS02000	COG0444	Belongs to the ABC transporter superfamily
A7U46_RS02005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7U46_RS02010	COG0601	transmembrane transport
A7U46_RS02040	COG1881	PFAM PEBP family protein
A7U46_RS02055	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A7U46_RS02080	COG0561	phosphatase activity
A7U46_RS02120	COG0398	Pfam SNARE associated Golgi protein
A7U46_RS02140	COG0584	glycerophosphoryl diester phosphodiesterase
A7U46_RS02160	COG1902	pentaerythritol trinitrate reductase activity
A7U46_RS02165	COG1098	S1 RNA binding domain
A7U46_RS02220	COG2050	protein possibly involved in aromatic compounds catabolism
A7U46_RS02225	COG2056	Na+-H+ antiporter family
A7U46_RS02230	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A7U46_RS02240	COG0316	Belongs to the HesB IscA family
A7U46_RS02250	COG1252	NADH dehydrogenase
A7U46_RS02255	COG4837	Protein of unknown function (DUF1462)
A7U46_RS02260	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A7U46_RS02265	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
A7U46_RS02275	COG1696	Membrane protein involved in D-alanine export
A7U46_RS02305	COG2445	Protein of unknown function DUF86
A7U46_RS02315	COG4470	Protein conserved in bacteria
A7U46_RS02330	COG0730	response to heat
A7U46_RS02335	COG1801	Protein of unknown function DUF72
A7U46_RS02350	COG1253	flavin adenine dinucleotide binding
A7U46_RS02375	COG0822	iron-sulfur transferase activity
A7U46_RS02385	COG0719	Fe-S assembly protein
A7U46_RS02390	COG0396	ATPase activity
A7U46_RS02405	COG1464	Belongs to the NlpA lipoprotein family
A7U46_RS02410	COG2011	ABC-type metal ion transport system permease component
A7U46_RS02425	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
A7U46_RS02435	COG3878	Protein conserved in bacteria
A7U46_RS02450	COG1393	Belongs to the ArsC family
A7U46_RS02455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A7U46_RS02480	COG1279	arginine transmembrane transporter activity
A7U46_RS02485	COG0406	alpha-ribazole phosphatase activity
A7U46_RS02525	COG1278	Cold shock
A7U46_RS02600	COG0557	exoribonuclease II activity
A7U46_RS02605	COG1647	Serine aminopeptidase, S33
A7U46_RS02610	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A7U46_RS02675	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A7U46_RS02735	COG1388	LysM domain
A7U46_RS02735	COG3942	CHAP domain
A7U46_RS02765	COG1040	competence protein
A7U46_RS02770	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
A7U46_RS02780	COG1739	Uncharacterized protein family UPF0029
A7U46_RS02785	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A7U46_RS02840	COG4607	ABC-type enterochelin transport system periplasmic component
A7U46_RS02845	COG4604	ABC transporter, ATP-binding protein
A7U46_RS02850	COG4605	iron ion homeostasis
A7U46_RS02855	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7U46_RS02875	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A7U46_RS02880	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A7U46_RS02910	COG3104	oligopeptide transport
A7U46_RS02940	COG1174	glycine betaine transport
A7U46_RS02945	COG0517	IMP dehydrogenase activity
A7U46_RS02945	COG1125	glycine betaine transport
A7U46_RS02950	COG0514	ATP-dependent DNA helicase (RecQ)
A7U46_RS02955	COG0488	(ABC) transporter
A7U46_RS02985	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A7U46_RS02990	COG0512	Glutamine amidotransferase of anthranilate synthase
A7U46_RS02990	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A7U46_RS03000	COG0720	synthase
A7U46_RS03035	COG0463	Glycosyl transferase, family 2
A7U46_RS03040	COG0656	L-ascorbic acid biosynthetic process
A7U46_RS03045	COG1253	flavin adenine dinucleotide binding
A7U46_RS03050	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A7U46_RS03055	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A7U46_RS03055	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A7U46_RS03055	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7U46_RS03060	COG1105	Belongs to the carbohydrate kinase PfkB family
A7U46_RS03065	COG1349	DNA-binding transcription factor activity
A7U46_RS03070	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A7U46_RS03100	COG0415	Belongs to the DNA photolyase family
A7U46_RS03105	COG0471	metal ion transport
A7U46_RS03115	COG4989	oxidoreductase activity
A7U46_RS03120	COG0523	cobalamin synthesis protein
A7U46_RS03130	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A7U46_RS03135	COG4988	ABC transporter
A7U46_RS03155	COG1611	Belongs to the LOG family
A7U46_RS03185	COG2839	Protein conserved in bacteria
A7U46_RS03190	COG2814	Major facilitator Superfamily
A7U46_RS03200	COG0583	DNA-binding transcription factor activity
A7U46_RS03240	COG3942	CHAP domain
A7U46_RS03240	COG1388	LysM domain
A7U46_RS03245	COG0306	phosphate transporter
A7U46_RS03250	COG1392	Phosphate transport regulator
A7U46_RS03255	COG0577	efflux transmembrane transporter activity
A7U46_RS03260	COG1136	(ABC) transporter
A7U46_RS03275	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A7U46_RS03300	COG3949	Membrane
A7U46_RS03310	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
A7U46_RS03320	COG2376	Dihydroxyacetone kinase
A7U46_RS03325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7U46_RS03330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7U46_RS03335	COG1120	ATPase activity
A7U46_RS03340	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A7U46_RS03350	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A7U46_RS03355	COG1132	(ABC) transporter
A7U46_RS03360	COG1686	Belongs to the peptidase S11 family
A7U46_RS03365	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A7U46_RS03370	COG1216	Glycosyl transferase, family 2
A7U46_RS03375	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A7U46_RS03380	COG1682	transport, permease protein
A7U46_RS03390	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
A7U46_RS03400	COG1321	iron dependent repressor
A7U46_RS03405	COG1121	(ABC) transporter
A7U46_RS03410	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A7U46_RS03460	COG4974	Belongs to the 'phage' integrase family
A7U46_RS03495	COG2946	Replication initiation factor
A7U46_RS03515	COG0433	COG0433 Predicted ATPase
A7U46_RS03520	COG1674	ftsk spoiiie
A7U46_RS03550	COG2826	transposase and inactivated derivatives, IS30 family
A7U46_RS03590	COG4139	cobalamin transport
A7U46_RS03595	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A7U46_RS03635	COG1078	dGTPase activity
A7U46_RS03645	COG0655	NAD(P)H dehydrogenase (quinone) activity
A7U46_RS03650	COG0667	Aldo Keto reductase
A7U46_RS03760	COG0083	homoserine kinase activity
A7U46_RS03765	COG0095	Lipoate-protein ligase
A7U46_RS03880	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A7U46_RS03925	COG0561	phosphatase activity
A7U46_RS03935	COG1428	Deoxynucleoside kinase
A7U46_RS03940	COG1428	Deoxynucleoside kinase
A7U46_RS03945	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A7U46_RS03980	COG1473	amidohydrolase
A7U46_RS04020	COG2813	Specifically methylates the guanine in position
A7U46_RS04080	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
A7U46_RS04105	COG4956	integral membrane protein (PIN domain superfamily)
A7U46_RS04110	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A7U46_RS04125	COG3880	PFAM UvrB UvrC protein
A7U46_RS04135	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A7U46_RS04150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7U46_RS04245	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A7U46_RS04270	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A7U46_RS04285	COG1098	S1 RNA binding domain
A7U46_RS04295	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A7U46_RS04300	COG3956	TIGRFAM MazG family protein
A7U46_RS04305	COG2244	polysaccharide biosynthetic process
A7U46_RS04350	COG0251	oxidation-reduction process
A7U46_RS04355	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A7U46_RS04365	COG4466	Protein conserved in bacteria
A7U46_RS04375	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
A7U46_RS04380	COG0084	hydrolase, TatD family'
A7U46_RS04390	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A7U46_RS04400	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A7U46_RS04410	COG1774	PSP1 C-terminal conserved region
A7U46_RS04415	COG0470	DNA polymerase III
A7U46_RS04420	COG3870	Protein conserved in bacteria
A7U46_RS04430	COG1982	Orn Lys Arg decarboxylase major
A7U46_RS04470	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A7U46_RS04490	COG2188	Transcriptional regulator
A7U46_RS04495	COG0366	Alpha amylase catalytic
A7U46_RS04500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7U46_RS04500	COG1263	PTS System
A7U46_RS04510	COG0493	'glutamate synthase
A7U46_RS04515	COG0070	glutamate synthase
A7U46_RS04515	COG0067	glutamate synthase
A7U46_RS04515	COG0069	glutamate synthase activity
A7U46_RS04520	COG0583	DNA-binding transcription factor activity
A7U46_RS04555	COG1464	Belongs to the NlpA lipoprotein family
A7U46_RS04560	COG2011	ABC-type metal ion transport system permease component
A7U46_RS04570	COG0626	cystathionine gamma-synthase activity
A7U46_RS04575	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A7U46_RS04580	COG0733	neurotransmitter:sodium symporter activity
A7U46_RS04590	COG1647	Serine aminopeptidase, S33
A7U46_RS04605	COG5609	conserved protein (DUF2294)
A7U46_RS04615	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A7U46_RS04640	COG0523	cobalamin synthesis protein
A7U46_RS04805	COG3759	membrane
A7U46_RS04845	COG2233	PERMEase
A7U46_RS04880	COG1823	symporter activity
A7U46_RS04895	COG3634	alkyl hydroperoxide reductase activity
A7U46_RS04990	COG0012	GTP binding
A7U46_RS04995	COG4481	Protein conserved in bacteria
A7U46_RS05000	COG0668	transmembrane transport
A7U46_RS05005	COG1475	DNA binding
A7U46_RS05015	COG0626	cystathionine gamma-synthase activity
A7U46_RS05020	COG0626	cystathionine gamma-synthase activity
A7U46_RS05025	COG0646	methionine synthase
A7U46_RS05025	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A7U46_RS05055	COG1131	(ABC) transporter
A7U46_RS05065	COG1476	TRANSCRIPTIONal
A7U46_RS05075	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A7U46_RS05080	COG0805	protein transport
A7U46_RS05085	COG0672	)-iron permease
A7U46_RS05100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A7U46_RS05115	COG0431	NADPH-dependent FMN reductase
A7U46_RS05120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7U46_RS05125	COG0346	lactoylglutathione lyase activity
A7U46_RS05130	COG2271	Major facilitator Superfamily
A7U46_RS05155	COG3711	transcriptional antiterminator
A7U46_RS05160	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7U46_RS05170	COG3037	sugar-specific permease SgaT UlaA
A7U46_RS05200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7U46_RS05225	COG3314	Sporulation integral membrane protein YlbJ
A7U46_RS05250	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A7U46_RS05255	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A7U46_RS05285	COG0577	efflux transmembrane transporter activity
A7U46_RS05295	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
A7U46_RS05305	COG1114	Component of the transport system for branched-chain amino acids
A7U46_RS05455	COG3942	CHAP domain
A7U46_RS05455	COG1388	LysM domain
A7U46_RS05485	COG1131	(ABC) transporter
A7U46_RS05545	COG2226	methyltransferase
A7U46_RS05555	COG2723	6-phospho-beta-galactosidase activity
A7U46_RS05560	COG2190	(PTS) system
A7U46_RS05560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7U46_RS05560	COG1263	PTS System
A7U46_RS05570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7U46_RS05605	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A7U46_RS05610	COG1063	alcohol dehydrogenase
A7U46_RS05620	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A7U46_RS05625	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A7U46_RS05630	COG1063	alcohol dehydrogenase
A7U46_RS05640	COG1063	alcohol dehydrogenase
A7U46_RS05650	COG1063	alcohol dehydrogenase
A7U46_RS05655	COG3775	system Galactitol-specific IIC component
A7U46_RS05660	COG3414	Phosphotransferase system galactitol-specific IIB component
A7U46_RS05680	COG1957	nucleoside hydrolase
A7U46_RS05685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7U46_RS05685	COG1263	PTS System
A7U46_RS05685	COG2190	(PTS) system
A7U46_RS05720	COG3189	MarR family transcriptional regulator
A7U46_RS05725	COG0747	negative chemotaxis
A7U46_RS05740	COG0318	PFAM AMP-dependent synthetase and ligase
A7U46_RS05745	COG1960	acyl-CoA dehydrogenase activity
A7U46_RS05755	COG0183	Belongs to the thiolase family
A7U46_RS05815	COG1755	Isoprenylcysteine carboxyl methyltransferase
A7U46_RS05825	COG0673	inositol 2-dehydrogenase activity
A7U46_RS05830	COG0673	inositol 2-dehydrogenase activity
A7U46_RS05835	COG3833	ABC-type maltose transport systems, permease component
A7U46_RS05840	COG1175	transmembrane transport
A7U46_RS05850	COG3842	ATPase activity
A7U46_RS05870	COG0405	Gamma-glutamyltransferase
A7U46_RS05880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7U46_RS05885	COG0601	transmembrane transport
A7U46_RS05920	COG1737	Transcriptional regulator
A7U46_RS05950	COG3961	Belongs to the TPP enzyme family
A7U46_RS05955	COG1335	isochorismatase
A7U46_RS05960	COG1114	Component of the transport system for branched-chain amino acids
A7U46_RS06010	COG5609	conserved protein (DUF2294)
A7U46_RS06015	COG1960	acyl-CoA dehydrogenase activity
A7U46_RS06020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A7U46_RS06055	COG2832	Protein of unknown function (DUF454)
A7U46_RS06065	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A7U46_RS06070	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A7U46_RS06080	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A7U46_RS06110	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A7U46_RS06120	COG1086	Polysaccharide biosynthesis protein
A7U46_RS06145	COG1454	alcohol dehydrogenase
A7U46_RS06145	COG1012	belongs to the aldehyde dehydrogenase family
A7U46_RS06175	COG0737	Belongs to the 5'-nucleotidase family
A7U46_RS06195	COG3639	organic phosphonate transmembrane transporter activity
A7U46_RS06215	COG2814	Major facilitator Superfamily
A7U46_RS06220	COG0813	purine-nucleoside phosphorylase activity
A7U46_RS06255	COG0438	transferase activity, transferring glycosyl groups
A7U46_RS06260	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A7U46_RS06265	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A7U46_RS06295	COG1475	DNA binding
A7U46_RS06300	COG0019	diaminopimelate decarboxylase activity
A7U46_RS06310	COG4264	IucA IucC family
A7U46_RS06315	COG4264	IucA IucC family
A7U46_RS06320	COG2814	Major facilitator Superfamily
A7U46_RS06325	COG4264	IucA IucC family
A7U46_RS06330	COG2423	ornithine cyclodeaminase activity
A7U46_RS06340	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A7U46_RS06345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7U46_RS06350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7U46_RS06370	COG1620	l-lactate permease
A7U46_RS06385	COG0697	spore germination
A7U46_RS06390	COG4716	Myosin-crossreactive antigen
A7U46_RS06395	COG1283	sodium-dependent phosphate transmembrane transporter activity
A7U46_RS06405	COG1473	amidohydrolase
A7U46_RS06440	COG0823	Involved in the tonB-independent uptake of proteins
A7U46_RS06460	COG0583	DNA-binding transcription factor activity
A7U46_RS06520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A7U46_RS06525	COG2210	Belongs to the sulfur carrier protein TusA family
A7U46_RS06530	COG1937	Protein conserved in bacteria
A7U46_RS06535	COG0730	response to heat
A7U46_RS06565	COG1388	LysM domain
A7U46_RS06575	COG1124	(ABC) transporter
A7U46_RS06580	COG4172	Belongs to the ABC transporter superfamily
A7U46_RS06585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7U46_RS06635	COG2235	arginine
A7U46_RS06645	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A7U46_RS06650	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A7U46_RS06700	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A7U46_RS06830	COG2030	dehydratase
A7U46_RS06835	COG0584	glycerophosphoryl diester phosphodiesterase
A7U46_RS06865	COG0737	Belongs to the 5'-nucleotidase family
A7U46_RS06870	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A7U46_RS06880	COG4863	YycH protein
A7U46_RS06915	COG0305	Participates in initiation and elongation during chromosome replication
A7U46_RS06925	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
A7U46_RS06935	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A7U46_RS06965	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A7U46_RS06985	COG2501	S4 domain
A7U46_RS07025	COG1475	DNA binding
A7U46_RS07050	COG1278	Cold shock
A7U46_RS07080	COG0577	efflux transmembrane transporter activity
A7U46_RS07085	COG1136	(ABC) transporter
A7U46_RS07100	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
A7U46_RS07110	COG2962	Rard protein
A7U46_RS07115	COG0471	metal ion transport
A7U46_RS07200	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A7U46_RS07235	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
A7U46_RS07290	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A7U46_RS07310	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A7U46_RS07330	COG1073	alpha beta
A7U46_RS07345	COG0438	transferase activity, transferring glycosyl groups
A7U46_RS07360	COG3433	isochorismatase activity
A7U46_RS07360	COG1535	isochorismatase
A7U46_RS07365	COG1705	Flagellar rod assembly protein muramidase FlgJ
A7U46_RS07365	COG3942	CHAP domain
A7U46_RS07375	COG1482	cell wall glycoprotein biosynthetic process
A7U46_RS07380	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A7U46_RS07380	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7U46_RS07380	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A7U46_RS07385	COG3711	transcriptional antiterminator
A7U46_RS07385	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7U46_RS07405	COG1438	arginine binding
A7U46_RS07450	COG1846	Transcriptional regulator
A7U46_RS07460	COG1785	Belongs to the alkaline phosphatase family
A7U46_RS07470	COG0745	RESPONSE REGULATOR receiver
A7U46_RS07475	COG2205	protein histidine kinase activity
A7U46_RS07480	COG1136	(ABC) transporter
A7U46_RS07505	COG0386	Belongs to the glutathione peroxidase family
A7U46_RS07515	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A7U46_RS07530	COG2851	Citrate transporter
A7U46_RS07555	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A7U46_RS07565	COG1510	regulation of RNA biosynthetic process
A7U46_RS07575	COG1012	belongs to the aldehyde dehydrogenase family
A7U46_RS07595	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A7U46_RS07625	COG0531	amino acid
A7U46_RS07640	COG3527	Alpha-acetolactate decarboxylase
A7U46_RS07645	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A7U46_RS07695	COG0167	dihydroorotate dehydrogenase activity
A7U46_RS07700	COG3001	Fructosamine kinase
A7U46_RS07810	COG2755	lipolytic protein G-D-S-L family
A7U46_RS07810	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A7U46_RS07815	COG3942	CHAP domain
A7U46_RS07845	COG0436	Aminotransferase
A7U46_RS07890	COG2409	Drug exporters of the RND superfamily
A7U46_RS07910	COG0542	response to heat
A7U46_RS07915	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A7U46_RS07920	COG3425	synthase
A7U46_RS07945	COG3942	CHAP domain
A7U46_RS07955	COG0583	DNA-binding transcription factor activity
A7U46_RS07970	COG0028	Belongs to the TPP enzyme family
A7U46_RS07990	COG0657	acetylesterase activity
A7U46_RS07995	COG0697	spore germination
A7U46_RS08010	COG1760	l-serine dehydratase
A7U46_RS08015	COG1760	l-serine dehydratase
A7U46_RS08035	COG3764	Sortase (surface protein transpeptidase)
A7U46_RS08045	COG1131	(ABC) transporter
A7U46_RS08050	COG0561	phosphatase activity
A7U46_RS08065	COG2514	catechol 2,3-dioxygenase activity
A7U46_RS08075	COG1846	Transcriptional regulator
A7U46_RS08080	COG0346	lactoylglutathione lyase activity
A7U46_RS08085	COG0400	carboxylic ester hydrolase activity
A7U46_RS08090	COG3949	Membrane
A7U46_RS08105	COG1131	(ABC) transporter
A7U46_RS08120	COG1846	Transcriptional regulator
A7U46_RS08125	COG2814	Major facilitator Superfamily
A7U46_RS08135	COG0586	Pfam SNARE associated Golgi protein
A7U46_RS08140	COG2271	Major facilitator Superfamily
A7U46_RS08150	COG4876	unkown
A7U46_RS08155	COG2357	RelA SpoT domain protein
A7U46_RS08160	COG0789	Transcriptional regulator
A7U46_RS08165	COG1802	Transcriptional regulator
A7U46_RS08170	COG1070	Carbohydrate kinase
A7U46_RS08205	COG1846	Transcriptional regulator
A7U46_RS08210	COG1846	Transcriptional regulator
A7U46_RS08250	COG0494	nUDIX hydrolase
A7U46_RS08340	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A7U46_RS08345	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A7U46_RS08375	COG0747	negative chemotaxis
A7U46_RS08380	COG0601	transmembrane transport
A7U46_RS08385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7U46_RS08390	COG0444	Belongs to the ABC transporter superfamily
A7U46_RS08395	COG1124	(ABC) transporter
A7U46_RS08410	COG0069	glutamate synthase activity
A7U46_RS08415	COG4808	Protein conserved in bacteria
A7U46_RS08435	COG1363	Peptidase, m42
A7U46_RS08440	COG4619	ABC transporter
A7U46_RS08445	COG0390	transport system, permease component
A7U46_RS08450	COG2814	Major facilitator Superfamily
A7U46_RS08455	COG2272	Belongs to the type-B carboxylesterase lipase family
A7U46_RS08460	COG0531	amino acid
A7U46_RS08470	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
A7U46_RS08490	COG1174	glycine betaine transport
A7U46_RS08500	COG1174	glycine betaine transport
A7U46_RS08510	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A7U46_RS08535	COG0531	amino acid
A7U46_RS08550	COG1113	amino acid transport
A7U46_RS08570	COG2814	Major facilitator Superfamily
A7U46_RS08580	COG1929	Belongs to the glycerate kinase type-1 family
A7U46_RS08600	COG2375	cellular response to nickel ion
A7U46_RS08600	COG1132	(ABC) transporter
A7U46_RS08605	COG1132	(ABC) transporter
A7U46_RS08620	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A7U46_RS08625	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A7U46_RS08635	COG0156	8-amino-7-oxononanoate synthase activity
A7U46_RS08685	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A7U46_RS08705	COG2814	Major facilitator Superfamily
A7U46_RS08710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7U46_RS08715	COG0765	amino acid transport
A7U46_RS08720	COG1126	abc transporter atp-binding protein
A7U46_RS08760	COG3443	Belongs to the bacterial solute-binding protein 9 family
A7U46_RS08760	COG0803	Belongs to the bacterial solute-binding protein 9 family
A7U46_RS08775	COG2116	formate transmembrane transporter activity
A7U46_RS08780	COG0454	-acetyltransferase
A7U46_RS08790	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A7U46_RS08795	COG2146	nitrite reductase [NAD(P)H] activity
A7U46_RS08805	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
A7U46_RS08810	COG1140	nitrate reductase beta subunit
A7U46_RS08820	COG2181	nitrate reductase activity
A7U46_RS08840	COG0789	Transcriptional regulator
A7U46_RS08880	COG3871	stress protein (general stress protein 26)
A7U46_RS08895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7U46_RS08895	COG1263	PTS System
A7U46_RS08910	COG1511	domain protein
A7U46_RS08935	COG0456	acetyltransferase
A7U46_RS08940	COG0604	alcohol dehydrogenase
A7U46_RS08960	COG1620	l-lactate permease
A7U46_RS09030	COG2814	Major facilitator Superfamily
A7U46_RS09040	COG1566	PFAM secretion protein HlyD family protein
A7U46_RS09045	COG2814	Major facilitator Superfamily
A7U46_RS09055	COG0657	acetylesterase activity
A7U46_RS09070	COG0598	Magnesium transport protein CorA
A7U46_RS09080	COG0786	glutamate:sodium symporter activity
A7U46_RS09095	COG3152	Membrane
A7U46_RS09100	COG4152	abc transporter atp-binding protein
A7U46_RS09105	COG1668	transmembrane transport
A7U46_RS09125	COG2258	MOSC domain
A7U46_RS09150	COG0583	DNA-binding transcription factor activity
A7U46_RS09165	COG1473	amidohydrolase
A7U46_RS09170	COG1028	Short-chain dehydrogenase reductase Sdr
A7U46_RS09190	COG1737	Transcriptional regulator
A7U46_RS09195	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7U46_RS09195	COG1263	PTS System
A7U46_RS09205	COG0385	Bile acid
A7U46_RS09210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A7U46_RS09230	COG1113	amino acid transport
A7U46_RS09305	COG3942	CHAP domain
A7U46_RS09320	COG1757	Na H antiporter
A7U46_RS09330	COG3942	CHAP domain
A7U46_RS09395	COG4413	Urea transporter
A7U46_RS09400	COG1960	acyl-CoA dehydrogenase activity
A7U46_RS09415	COG1268	BioY protein
A7U46_RS09430	COG0725	ABC transporter, periplasmic molybdate-binding protein
A7U46_RS09435	COG4149	molybdate abc transporter
A7U46_RS09440	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A7U46_RS09445	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A7U46_RS09465	COG1763	Mo-molybdopterin cofactor biosynthetic process
A7U46_RS09540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A7U46_RS09585	COG2252	PERMEase
A7U46_RS09700	COG0201	protein transport
A7U46_RS09785	COG0542	response to heat
A7U46_RS09805	COG0028	Belongs to the TPP enzyme family
A7U46_RS09810	COG3527	Alpha-acetolactate decarboxylase
A7U46_RS09830	COG5492	domain, Protein
A7U46_RS09840	COG0789	Transcriptional regulator
A7U46_RS09845	COG0656	L-ascorbic acid biosynthetic process
A7U46_RS09865	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A7U46_RS09915	COG2130	NADP-dependent
A7U46_RS09925	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A7U46_RS09955	COG2814	Major facilitator Superfamily
A7U46_RS09960	COG4264	IucA IucC family
A7U46_RS09965	COG3457	Alanine racemase
A7U46_RS09975	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
A7U46_RS09980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7U46_RS09985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7U46_RS09990	COG3314	Sporulation integral membrane protein YlbJ
A7U46_RS10000	COG1988	membrane-bound metal-dependent
A7U46_RS10010	COG1272	protein, Hemolysin III
A7U46_RS10025	COG2814	Major facilitator Superfamily
A7U46_RS10030	COG0489	protein tyrosine kinase activity
A7U46_RS10105	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A7U46_RS10135	COG3711	transcriptional antiterminator
A7U46_RS10150	COG1119	ATPase activity
A7U46_RS10155	COG0561	phosphatase activity
A7U46_RS10190	COG0640	Transcriptional regulator
A7U46_RS10195	COG0702	epimerase
A7U46_RS10200	COG1482	cell wall glycoprotein biosynthetic process
A7U46_RS10220	COG0783	Belongs to the Dps family
A7U46_RS10225	COG0813	purine-nucleoside phosphorylase activity
A7U46_RS10275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A7U46_RS10315	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A7U46_RS10340	COG2890	protein-(glutamine-N5) methyltransferase activity
A7U46_RS10345	COG0009	L-threonylcarbamoyladenylate synthase
A7U46_RS10370	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A7U46_RS10445	COG0629	single-stranded DNA binding
A7U46_RS10495	COG1418	mRNA catabolic process
A7U46_RS10505	COG1937	Protein conserved in bacteria
A7U46_RS10520	COG0772	Belongs to the SEDS family
A7U46_RS10530	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A7U46_RS10540	COG0745	RESPONSE REGULATOR receiver
A7U46_RS10545	COG2205	protein histidine kinase activity
A7U46_RS10575	COG3428	Bacterial PH domain
A7U46_RS10610	COG2208	phosphoserine phosphatase activity
A7U46_RS10615	COG1366	Belongs to the anti-sigma-factor antagonist family
A7U46_RS10625	COG1191	sigma factor activity
A7U46_RS10630	COG2183	response to ionizing radiation
A7U46_RS10705	COG0028	Belongs to the TPP enzyme family
A7U46_RS10720	COG0802	atpase or kinase
A7U46_RS10725	COG1214	PFAM Peptidase M22, glycoprotease
A7U46_RS10730	COG0456	acetyltransferase
A7U46_RS10740	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A7U46_RS10750	COG0488	(ABC) transporter
A7U46_RS10760	COG2391	methyltransferase activity
A7U46_RS10765	COG0425	Belongs to the sulfur carrier protein TusA family
A7U46_RS10770	COG0004	ammonium transporteR
A7U46_RS10775	COG1609	Transcriptional regulator
A7U46_RS10780	COG1621	beta-fructofuranosidase activity
A7U46_RS10785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A7U46_RS10860	COG3728	DNA packaging
A7U46_RS10860	COG5484	DNA packaging
A7U46_RS10880	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A7U46_RS10885	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A7U46_RS10890	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
A7U46_RS10940	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A7U46_RS11115	COG0740	serine-type endopeptidase activity
A7U46_RS11165	COG0739	heme binding
A7U46_RS11210	COG5632	N-Acetylmuramoyl-L-alanine amidase
A7U46_RS11210	COG1388	LysM domain
A7U46_RS11285	COG1725	Transcriptional regulator
A7U46_RS11300	COG1131	(ABC) transporter
A7U46_RS11355	COG1012	belongs to the aldehyde dehydrogenase family
A7U46_RS11370	COG1335	isochorismatase
A7U46_RS11390	COG0077	Prephenate dehydratase
A7U46_RS11400	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A7U46_RS11440	COG4496	protein, YerC YecD
A7U46_RS11450	COG0210	DNA helicase
A7U46_RS11460	COG4851	CamS sex pheromone cAM373 precursor
A7U46_RS11590	COG2197	response regulator
A7U46_RS11595	COG1295	ribonuclease BN
A7U46_RS11615	COG2309	aminopeptidase activity
A7U46_RS11620	COG1607	acyl-coa hydrolase
A7U46_RS11625	COG0535	radical SAM domain protein
A7U46_RS11655	COG1388	LysM domain
A7U46_RS11655	COG1134	teichoic acid transport
A7U46_RS11670	COG1988	membrane-bound metal-dependent
A7U46_RS11695	COG4129	membrane
A7U46_RS11705	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A7U46_RS11710	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A7U46_RS11890	COG0765	amino acid transport
A7U46_RS11895	COG1126	abc transporter atp-binding protein
A7U46_RS11900	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A7U46_RS11940	COG0564	pseudouridine synthase activity
A7U46_RS11945	COG4585	Histidine kinase
A7U46_RS11945	COG2203	Gaf domain
A7U46_RS11950	COG2197	response regulator
A7U46_RS11980	COG0420	3'-5' exonuclease activity
A7U46_RS12015	COG0537	adenosine 5'-monophosphoramidase activity
A7U46_RS12020	COG1131	(ABC) transporter
A7U46_RS12050	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
A7U46_RS12170	COG1131	(ABC) transporter
A7U46_RS12350	COG1506	peptidase
A7U46_RS12375	COG0656	L-ascorbic acid biosynthetic process
A7U46_RS12400	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A7U46_RS12430	COG5632	N-Acetylmuramoyl-L-alanine amidase
A7U46_RS12430	COG4193	domain, Protein
A7U46_RS12430	COG3266	domain, Protein
A7U46_RS12455	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A7U46_RS12455	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A7U46_RS12490	COG2267	carboxylic ester hydrolase activity
A7U46_RS12505	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A7U46_RS12510	COG1242	4 iron, 4 sulfur cluster binding
A7U46_RS12515	COG2814	Major facilitator Superfamily
A7U46_RS12535	COG2081	HI0933 family
A7U46_RS12540	COG2244	polysaccharide biosynthetic process
A7U46_RS12545	COG1187	pseudouridine synthase activity
A7U46_RS12570	COG0510	thiamine kinase activity
A7U46_RS12580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A7U46_RS12590	COG1363	Peptidase, m42
A7U46_RS12595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A7U46_RS12605	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A7U46_RS12610	COG1674	ftsk spoiiie
A7U46_RS12635	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A7U46_RS12635	COG1605	Chorismate mutase
A7U46_RS12655	COG0454	-acetyltransferase
A7U46_RS12660	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A7U46_RS12690	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A7U46_RS12695	COG0204	Acyl-transferase
A7U46_RS12700	COG1263	PTS System
A7U46_RS12700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7U46_RS12715	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A7U46_RS12720	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A7U46_RS12725	COG1764	response to oxidative stress
A7U46_RS12730	COG0584	glycerophosphoryl diester phosphodiesterase
A7U46_RS12750	COG1956	GAF domain-containing protein
A7U46_RS12765	COG1104	cysteine desulfurase activity
A7U46_RS12785	COG0827	DNA restriction-modification system
A7U46_RS12825	COG4109	DRTGG domain
A7U46_RS12835	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A7U46_RS12845	COG0281	malic enzyme
A7U46_RS12875	COG1113	amino acid transport
A7U46_RS12880	COG0372	Belongs to the citrate synthase family
A7U46_RS12895	COG0745	RESPONSE REGULATOR receiver
A7U46_RS12900	COG5002	protein histidine kinase activity
A7U46_RS12910	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A7U46_RS12910	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A7U46_RS12940	COG1484	DNA-dependent DNA replication
A7U46_RS12955	COG0833	amino acid
A7U46_RS12980	COG4112	unkown
A7U46_RS13015	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A7U46_RS13050	COG2818	Glycosylase
A7U46_RS13060	COG0285	dihydrofolate synthase activity
A7U46_RS13070	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A7U46_RS13115	COG2868	ribosomal protein
A7U46_RS13155	COG1862	Preprotein translocase
A7U46_RS13160	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A7U46_RS13160	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A7U46_RS13165	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A7U46_RS13165	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A7U46_RS13210	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A7U46_RS13215	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A7U46_RS13220	COG1959	2 iron, 2 sulfur cluster binding
A7U46_RS13235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7U46_RS13240	COG1104	cysteine desulfurase activity
A7U46_RS13255	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A7U46_RS13285	COG0826	peptidase U32
A7U46_RS13290	COG0826	peptidase U32
A7U46_RS13305	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A7U46_RS13310	COG1984	allophanate hydrolase subunit 2
A7U46_RS13315	COG0511	ligase activity, forming carbon-carbon bonds
A7U46_RS13320	COG0439	Biotin carboxylase
A7U46_RS13330	COG1914	H( )-stimulated, divalent metal cation uptake system
A7U46_RS13335	COG3177	Filamentation induced by cAMP protein fic
A7U46_RS13355	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
A7U46_RS13360	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A7U46_RS13370	COG1534	Rna-binding protein
A7U46_RS13380	COG1713	HD superfamily hydrolase involved in NAD metabolism
A7U46_RS13385	COG0799	negative regulation of ribosome biogenesis
A7U46_RS13390	COG2226	methyltransferase
A7U46_RS13400	COG2131	deaminase
A7U46_RS13405	COG2333	competence protein COMEC
A7U46_RS13405	COG0658	competence protein
A7U46_RS13410	COG1466	dna polymerase III delta subunit
A7U46_RS13430	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A7U46_RS13460	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A7U46_RS13465	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A7U46_RS13475	COG1030	water channel activity
A7U46_RS13490	COG1702	phosphate starvation-inducible protein PhoH
A7U46_RS13505	COG0295	cytidine deaminase activity
A7U46_RS13525	COG0517	IMP dehydrogenase activity
A7U46_RS13545	COG2384	SAM-dependent methyltransferase
A7U46_RS13555	COG0513	Belongs to the DEAD box helicase family
A7U46_RS13565	COG1121	(ABC) transporter
A7U46_RS13570	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A7U46_RS13585	COG0768	penicillin binding
A7U46_RS13595	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A7U46_RS13605	COG4483	Protein conserved in bacteria
A7U46_RS13610	COG1940	carbohydrate kinase activity
A7U46_RS13615	COG0011	TIGRFAM Protein of
A7U46_RS13620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A7U46_RS13625	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A7U46_RS13630	COG1459	type II secretion system
A7U46_RS13635	COG4537	Required for transformation and DNA binding
A7U46_RS13680	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A7U46_RS13685	COG0095	Lipoate-protein ligase
A7U46_RS13700	COG0006	proline dipeptidase activity
A7U46_RS13710	COG0511	ligase activity, forming carbon-carbon bonds
A7U46_RS13715	COG0439	Biotin carboxylase
A7U46_RS13720	COG1302	Protein conserved in bacteria
A7U46_RS13750	COG0497	DNA recombination
A7U46_RS13755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A7U46_RS13760	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A7U46_RS13765	COG0022	dehydrogenase e1 component
A7U46_RS13770	COG0508	dehydrogenase complex catalyzes the overall conversion of
A7U46_RS13780	COG4129	membrane
A7U46_RS13790	COG2195	Cleaves the N-terminal amino acid of tripeptides
A7U46_RS13810	COG1609	Transcriptional regulator
A7U46_RS13815	COG0366	Alpha amylase catalytic
A7U46_RS13825	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A7U46_RS13840	COG4221	oxidoreductase activity
A7U46_RS13850	COG0667	Aldo Keto reductase
A7U46_RS13855	COG0494	nUDIX hydrolase
A7U46_RS13860	COG0735	belongs to the Fur family
A7U46_RS13885	COG1187	pseudouridine synthase activity
A7U46_RS13890	COG0745	RESPONSE REGULATOR receiver
A7U46_RS13895	COG5002	protein histidine kinase activity
A7U46_RS13915	COG0582	viral genome integration into host DNA
A7U46_RS14175	COG3953	SLT domain
A7U46_RS14175	COG5280	Phage tail tape measure protein TP901
A7U46_RS14225	COG1388	LysM domain
A7U46_RS14225	COG0860	N-Acetylmuramoyl-L-alanine amidase
A7U46_RS14275	COG1141	Ferredoxin
A7U46_RS14285	COG0514	ATP-dependent DNA helicase (RecQ)
A7U46_RS14300	COG0492	ferredoxin-NADP+ reductase activity
A7U46_RS14365	COG0142	geranyltranstransferase activity
A7U46_RS14405	COG4347	Protein of unknown function (DUF1405)
A7U46_RS14410	COG2738	Putative neutral zinc metallopeptidase
A7U46_RS14415	COG1694	Mazg nucleotide pyrophosphohydrolase
A7U46_RS14420	COG0438	transferase activity, transferring glycosyl groups
A7U46_RS14445	COG3935	DnaD domain protein
A7U46_RS14450	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A7U46_RS14460	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A7U46_RS14460	COG4499	WXG100 protein secretion system (Wss), protein YukC
A7U46_RS14500	COG0116	Belongs to the methyltransferase superfamily
A7U46_RS14515	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A7U46_RS14520	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A7U46_RS14535	COG0531	amino acid
A7U46_RS14560	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A7U46_RS14635	COG0671	phosphoesterase, PA-phosphatase related
A7U46_RS14690	COG4548	von Willebrand factor, type A
A7U46_RS14770	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A7U46_RS14775	COG0527	aspartate kinase activity
A7U46_RS14780	COG0488	(ABC) transporter
A7U46_RS14800	COG0573	inorganic phosphate transmembrane transporter activity
A7U46_RS14805	COG0581	inorganic phosphate transmembrane transporter activity
A7U46_RS14815	COG0704	Plays a role in the regulation of phosphate uptake
A7U46_RS14860	COG0561	phosphatase activity
A7U46_RS14900	COG0512	Glutamine amidotransferase of anthranilate synthase
A7U46_RS14905	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A7U46_RS14910	COG1363	Peptidase, m42
A7U46_RS14920	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A7U46_RS14940	COG0392	lysyltransferase activity
A7U46_RS14940	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A7U46_RS14945	COG0628	permease
A7U46_RS14960	COG1115	amino acid carrier protein
A7U46_RS15000	COG0824	Thioesterase
A7U46_RS15115	COG0551	DNA topoisomerase type I activity
A7U46_RS15115	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A7U46_RS15130	COG0551	DNA topoisomerase type I activity
A7U46_RS15190	COG1131	(ABC) transporter
A7U46_RS15200	COG3173	Aminoglycoside phosphotransferase
A7U46_RS15275	COG0604	alcohol dehydrogenase
A7U46_RS15300	COG3682	Transcriptional regulator