locus-tag	class	description
I5043_RS00015	COG2501	S4 domain
I5043_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I5043_RS00060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I5043_RS00070	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
I5043_RS00080	COG0305	Participates in initiation and elongation during chromosome replication
I5043_RS00110	COG4863	YycH protein
I5043_RS00120	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I5043_RS00125	COG0737	Belongs to the 5'-nucleotidase family
I5043_RS00140	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I5043_RS00175	COG0730	response to heat
I5043_RS00180	COG1937	Protein conserved in bacteria
I5043_RS00185	COG2210	Belongs to the sulfur carrier protein TusA family
I5043_RS00190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5043_RS00230	COG0823	Involved in the tonB-independent uptake of proteins
I5043_RS00245	COG1473	amidohydrolase
I5043_RS00255	COG1283	sodium-dependent phosphate transmembrane transporter activity
I5043_RS00260	COG4716	Myosin-crossreactive antigen
I5043_RS00270	COG1620	l-lactate permease
I5043_RS00285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5043_RS00290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5043_RS00295	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I5043_RS00305	COG2423	ornithine cyclodeaminase activity
I5043_RS00310	COG4264	IucA IucC family
I5043_RS00315	COG2814	Major facilitator Superfamily
I5043_RS00320	COG4264	IucA IucC family
I5043_RS00325	COG4264	IucA IucC family
I5043_RS00335	COG0019	diaminopimelate decarboxylase activity
I5043_RS00340	COG1475	DNA binding
I5043_RS00365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I5043_RS00370	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I5043_RS00375	COG0438	transferase activity, transferring glycosyl groups
I5043_RS00400	COG0813	purine-nucleoside phosphorylase activity
I5043_RS00405	COG2814	Major facilitator Superfamily
I5043_RS00425	COG3639	organic phosphonate transmembrane transporter activity
I5043_RS00445	COG0737	Belongs to the 5'-nucleotidase family
I5043_RS00460	COG1012	belongs to the aldehyde dehydrogenase family
I5043_RS00460	COG1454	alcohol dehydrogenase
I5043_RS00485	COG1086	Polysaccharide biosynthesis protein
I5043_RS00495	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I5043_RS00525	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I5043_RS00535	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I5043_RS00540	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I5043_RS00550	COG2832	Protein of unknown function (DUF454)
I5043_RS00585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5043_RS00590	COG1960	acyl-CoA dehydrogenase activity
I5043_RS00610	COG3477	response to acidic pH
I5043_RS00635	COG1114	Component of the transport system for branched-chain amino acids
I5043_RS00640	COG1335	isochorismatase
I5043_RS00645	COG3961	Belongs to the TPP enzyme family
I5043_RS00675	COG1737	Transcriptional regulator
I5043_RS00710	COG0601	transmembrane transport
I5043_RS00715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5043_RS00725	COG0405	Gamma-glutamyltransferase
I5043_RS00740	COG3842	ATPase activity
I5043_RS00750	COG1175	transmembrane transport
I5043_RS00755	COG3833	ABC-type maltose transport systems, permease component
I5043_RS00760	COG0673	inositol 2-dehydrogenase activity
I5043_RS00765	COG0673	inositol 2-dehydrogenase activity
I5043_RS00775	COG1755	Isoprenylcysteine carboxyl methyltransferase
I5043_RS00835	COG0183	Belongs to the thiolase family
I5043_RS00845	COG1960	acyl-CoA dehydrogenase activity
I5043_RS00850	COG0318	PFAM AMP-dependent synthetase and ligase
I5043_RS00865	COG0747	negative chemotaxis
I5043_RS00870	COG3189	MarR family transcriptional regulator
I5043_RS00895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5043_RS00895	COG2190	(PTS) system
I5043_RS00895	COG1263	PTS System
I5043_RS00900	COG1957	nucleoside hydrolase
I5043_RS00920	COG3414	Phosphotransferase system galactitol-specific IIB component
I5043_RS00925	COG3775	system Galactitol-specific IIC component
I5043_RS00930	COG1063	alcohol dehydrogenase
I5043_RS00940	COG1063	alcohol dehydrogenase
I5043_RS00950	COG1063	alcohol dehydrogenase
I5043_RS00955	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I5043_RS00960	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I5043_RS00970	COG1063	alcohol dehydrogenase
I5043_RS00975	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I5043_RS01020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5043_RS01025	COG2190	(PTS) system
I5043_RS01025	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5043_RS01025	COG1263	PTS System
I5043_RS01030	COG2723	6-phospho-beta-galactosidase activity
I5043_RS01035	COG2226	methyltransferase
I5043_RS01090	COG1131	(ABC) transporter
I5043_RS01120	COG1388	LysM domain
I5043_RS01120	COG3942	CHAP domain
I5043_RS01290	COG1114	Component of the transport system for branched-chain amino acids
I5043_RS01295	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
I5043_RS01300	COG0577	efflux transmembrane transporter activity
I5043_RS01325	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I5043_RS01330	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I5043_RS01355	COG3314	Sporulation integral membrane protein YlbJ
I5043_RS01380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5043_RS01405	COG3037	sugar-specific permease SgaT UlaA
I5043_RS01415	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5043_RS01420	COG3711	transcriptional antiterminator
I5043_RS01440	COG2271	Major facilitator Superfamily
I5043_RS01445	COG0346	lactoylglutathione lyase activity
I5043_RS01450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5043_RS01455	COG0431	NADPH-dependent FMN reductase
I5043_RS01465	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5043_RS01470	COG2822	iron ion transport
I5043_RS01480	COG0672	)-iron permease
I5043_RS01485	COG0805	protein transport
I5043_RS01490	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I5043_RS01500	COG1476	TRANSCRIPTIONal
I5043_RS01510	COG1131	(ABC) transporter
I5043_RS01540	COG0646	methionine synthase
I5043_RS01540	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I5043_RS01545	COG0626	cystathionine gamma-synthase activity
I5043_RS01550	COG0626	cystathionine gamma-synthase activity
I5043_RS01555	COG1475	DNA binding
I5043_RS01560	COG0668	transmembrane transport
I5043_RS01565	COG4481	Protein conserved in bacteria
I5043_RS01570	COG0012	GTP binding
I5043_RS01670	COG1823	symporter activity
I5043_RS01700	COG2233	PERMEase
I5043_RS01735	COG1683	Conserved Protein
I5043_RS01745	COG3759	membrane
I5043_RS01880	COG0523	cobalamin synthesis protein
I5043_RS01905	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I5043_RS01915	COG5609	conserved protein (DUF2294)
I5043_RS01930	COG1647	Serine aminopeptidase, S33
I5043_RS01940	COG0733	neurotransmitter:sodium symporter activity
I5043_RS01945	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I5043_RS01950	COG0626	cystathionine gamma-synthase activity
I5043_RS01960	COG2011	ABC-type metal ion transport system permease component
I5043_RS01965	COG1464	Belongs to the NlpA lipoprotein family
I5043_RS02000	COG0583	DNA-binding transcription factor activity
I5043_RS02005	COG0067	glutamate synthase
I5043_RS02005	COG0070	glutamate synthase
I5043_RS02005	COG0069	glutamate synthase activity
I5043_RS02010	COG0493	'glutamate synthase
I5043_RS02020	COG1263	PTS System
I5043_RS02020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5043_RS02025	COG0366	Alpha amylase catalytic
I5043_RS02030	COG2188	Transcriptional regulator
I5043_RS02050	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I5043_RS02090	COG1982	Orn Lys Arg decarboxylase major
I5043_RS02100	COG3870	Protein conserved in bacteria
I5043_RS02105	COG0470	DNA polymerase III
I5043_RS02110	COG1774	PSP1 C-terminal conserved region
I5043_RS02120	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I5043_RS02130	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I5043_RS02140	COG0084	hydrolase, TatD family'
I5043_RS02145	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I5043_RS02155	COG4466	Protein conserved in bacteria
I5043_RS02165	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I5043_RS02170	COG0251	oxidation-reduction process
I5043_RS02210	COG2244	polysaccharide biosynthetic process
I5043_RS02215	COG3956	TIGRFAM MazG family protein
I5043_RS02220	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I5043_RS02230	COG1098	S1 RNA binding domain
I5043_RS02245	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I5043_RS02270	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I5043_RS02365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5043_RS02380	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I5043_RS02390	COG3880	PFAM UvrB UvrC protein
I5043_RS02405	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I5043_RS02410	COG4956	integral membrane protein (PIN domain superfamily)
I5043_RS02430	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I5043_RS02485	COG2813	Specifically methylates the guanine in position
I5043_RS02525	COG1473	amidohydrolase
I5043_RS02555	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I5043_RS02560	COG1428	Deoxynucleoside kinase
I5043_RS02565	COG1428	Deoxynucleoside kinase
I5043_RS02575	COG0561	phosphatase activity
I5043_RS02615	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I5043_RS02720	COG0095	Lipoate-protein ligase
I5043_RS02725	COG0083	homoserine kinase activity
I5043_RS02745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I5043_RS02785	COG0667	Aldo Keto reductase
I5043_RS02790	COG0655	NAD(P)H dehydrogenase (quinone) activity
I5043_RS02800	COG1078	dGTPase activity
I5043_RS02830	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I5043_RS02835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5043_RS02885	COG4974	Belongs to the 'phage' integrase family
I5043_RS02930	COG0803	Belongs to the bacterial solute-binding protein 9 family
I5043_RS02935	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5043_RS02940	COG1121	(ABC) transporter
I5043_RS02945	COG1321	iron dependent repressor
I5043_RS02955	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I5043_RS02965	COG1682	transport, permease protein
I5043_RS02970	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I5043_RS02980	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I5043_RS02985	COG1686	Belongs to the peptidase S11 family
I5043_RS02990	COG1132	(ABC) transporter
I5043_RS02995	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I5043_RS03005	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I5043_RS03010	COG1120	ATPase activity
I5043_RS03015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5043_RS03020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5043_RS03025	COG2376	Dihydroxyacetone kinase
I5043_RS03035	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I5043_RS03045	COG3949	Membrane
I5043_RS03065	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I5043_RS03080	COG1136	(ABC) transporter
I5043_RS03085	COG0577	efflux transmembrane transporter activity
I5043_RS03090	COG1392	Phosphate transport regulator
I5043_RS03095	COG0306	phosphate transporter
I5043_RS03100	COG1388	LysM domain
I5043_RS03100	COG3942	CHAP domain
I5043_RS03110	COG4977	sequence-specific DNA binding
I5043_RS03110	COG1917	Cupin 2, conserved barrel domain protein
I5043_RS03140	COG0583	DNA-binding transcription factor activity
I5043_RS03150	COG2839	Protein conserved in bacteria
I5043_RS03180	COG1611	Belongs to the LOG family
I5043_RS03200	COG4988	ABC transporter
I5043_RS03205	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I5043_RS03215	COG0523	cobalamin synthesis protein
I5043_RS03220	COG4989	oxidoreductase activity
I5043_RS03230	COG0471	metal ion transport
I5043_RS03235	COG0415	Belongs to the DNA photolyase family
I5043_RS03265	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I5043_RS03270	COG1349	DNA-binding transcription factor activity
I5043_RS03275	COG1105	Belongs to the carbohydrate kinase PfkB family
I5043_RS03280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5043_RS03280	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5043_RS03280	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5043_RS03285	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I5043_RS03290	COG1253	flavin adenine dinucleotide binding
I5043_RS03295	COG0656	L-ascorbic acid biosynthetic process
I5043_RS03300	COG0463	Glycosyl transferase, family 2
I5043_RS03335	COG0720	synthase
I5043_RS03345	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I5043_RS03345	COG0512	Glutamine amidotransferase of anthranilate synthase
I5043_RS03350	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I5043_RS03380	COG0488	(ABC) transporter
I5043_RS03385	COG0514	ATP-dependent DNA helicase (RecQ)
I5043_RS03390	COG0517	IMP dehydrogenase activity
I5043_RS03390	COG1125	glycine betaine transport
I5043_RS03395	COG1174	glycine betaine transport
I5043_RS03415	COG3104	oligopeptide transport
I5043_RS03435	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I5043_RS03440	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I5043_RS03450	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5043_RS03455	COG4605	iron ion homeostasis
I5043_RS03460	COG4604	ABC transporter, ATP-binding protein
I5043_RS03465	COG4607	ABC-type enterochelin transport system periplasmic component
I5043_RS03520	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I5043_RS03525	COG1739	Uncharacterized protein family UPF0029
I5043_RS03535	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I5043_RS03540	COG1040	competence protein
I5043_RS03570	COG1388	LysM domain
I5043_RS03570	COG3942	CHAP domain
I5043_RS03625	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I5043_RS03640	COG0281	malic enzyme
I5043_RS03690	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I5043_RS03695	COG1647	Serine aminopeptidase, S33
I5043_RS03700	COG0557	exoribonuclease II activity
I5043_RS03760	COG1278	Cold shock
I5043_RS03800	COG0406	alpha-ribazole phosphatase activity
I5043_RS03805	COG1279	arginine transmembrane transporter activity
I5043_RS03830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I5043_RS03835	COG1393	Belongs to the ArsC family
I5043_RS03845	COG3878	Protein conserved in bacteria
I5043_RS03850	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I5043_RS03865	COG2011	ABC-type metal ion transport system permease component
I5043_RS03870	COG1464	Belongs to the NlpA lipoprotein family
I5043_RS03885	COG0396	ATPase activity
I5043_RS03890	COG0719	Fe-S assembly protein
I5043_RS03900	COG0822	iron-sulfur transferase activity
I5043_RS03920	COG1253	flavin adenine dinucleotide binding
I5043_RS03930	COG1801	Protein of unknown function DUF72
I5043_RS03935	COG0730	response to heat
I5043_RS03950	COG4470	Protein conserved in bacteria
I5043_RS03960	COG2445	Protein of unknown function DUF86
I5043_RS03990	COG1696	Membrane protein involved in D-alanine export
I5043_RS04000	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I5043_RS04005	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I5043_RS04010	COG4837	Protein of unknown function (DUF1462)
I5043_RS04015	COG1252	NADH dehydrogenase
I5043_RS04025	COG0316	Belongs to the HesB IscA family
I5043_RS04035	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I5043_RS04040	COG2056	Na+-H+ antiporter family
I5043_RS04045	COG2050	protein possibly involved in aromatic compounds catabolism
I5043_RS04100	COG1098	S1 RNA binding domain
I5043_RS04105	COG1902	pentaerythritol trinitrate reductase activity
I5043_RS04120	COG0584	glycerophosphoryl diester phosphodiesterase
I5043_RS04140	COG0398	Pfam SNARE associated Golgi protein
I5043_RS04180	COG0561	phosphatase activity
I5043_RS04220	COG1881	PFAM PEBP family protein
I5043_RS04250	COG0601	transmembrane transport
I5043_RS04255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5043_RS04260	COG0444	Belongs to the ABC transporter superfamily
I5043_RS04265	COG4608	Belongs to the ABC transporter superfamily
I5043_RS04270	COG4166	transmembrane transport
I5043_RS04275	COG0747	negative chemotaxis
I5043_RS04280	COG0444	Belongs to the ABC transporter superfamily
I5043_RS04285	COG4608	Belongs to the ABC transporter superfamily
I5043_RS04290	COG0601	transmembrane transport
I5043_RS04295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5043_RS04320	COG1164	Oligoendopeptidase f
I5043_RS04330	COG2346	COG2346, Truncated hemoglobins
I5043_RS04345	COG2357	RelA SpoT domain protein
I5043_RS04355	COG0564	pseudouridine synthase activity
I5043_RS04360	COG2239	Acts as a magnesium transporter
I5043_RS04365	COG0569	domain protein
I5043_RS04365	COG0475	glutathione-regulated potassium exporter activity
I5043_RS04375	COG0628	permease
I5043_RS04380	COG1115	amino acid carrier protein
I5043_RS04420	COG0861	Integral membrane protein TerC family
I5043_RS04430	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I5043_RS04435	COG0737	Belongs to the 5'-nucleotidase family
I5043_RS04450	COG4903	ComK protein
I5043_RS04465	COG4873	Protein conserved in bacteria
I5043_RS04515	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I5043_RS04525	COG2314	TM2 domain
I5043_RS04535	COG1575	Belongs to the MenA family. Type 1 subfamily
I5043_RS04540	COG1169	isochorismate synthase
I5043_RS04550	COG2267	carboxylic ester hydrolase activity
I5043_RS04575	COG0436	Aminotransferase
I5043_RS04580	COG3594	Acyltransferase
I5043_RS04610	COG1316	TRANSCRIPTIONal
I5043_RS04655	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I5043_RS04670	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I5043_RS04710	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I5043_RS04715	COG4172	Belongs to the ABC transporter superfamily
I5043_RS04720	COG4721	ABC-type cobalt transport system, permease component
I5043_RS04735	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I5043_RS04755	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I5043_RS04760	COG1271	oxidase subunit
I5043_RS04765	COG1294	oxidase, subunit
I5043_RS04770	COG0569	domain protein
I5043_RS04835	COG1176	ABC-type spermidine putrescine transport system, permease component I
I5043_RS04840	COG1177	transmembrane transport
I5043_RS04845	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I5043_RS04870	COG0483	inositol monophosphate 1-phosphatase activity
I5043_RS04880	COG1217	gtp-binding protein TYPA
I5043_RS04890	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I5043_RS04900	COG0772	Belongs to the SEDS family
I5043_RS04930	COG3679	Belongs to the UPF0342 family
I5043_RS04935	COG0584	glycerophosphoryl diester phosphodiesterase
I5043_RS04950	COG0742	ribosomal rna small subunit methyltransferase
I5043_RS05005	COG4509	Sortase family
I5043_RS05020	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I5043_RS05050	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I5043_RS05050	COG1796	DNA polymerase
I5043_RS05075	COG2009	succinate dehydrogenase
I5043_RS05080	COG1053	succinate dehydrogenase
I5043_RS05085	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I5043_RS05195	COG1288	antiporter activity
I5043_RS05230	COG1011	Hydrolase
I5043_RS05255	COG4839	cell division protein FtsL
I5043_RS05260	COG0768	penicillin binding
I5043_RS05275	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I5043_RS05280	COG0849	cell division
I5043_RS05295	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I5043_RS05305	COG0762	integral membrane protein
I5043_RS05310	COG2302	S4 RNA-binding domain
I5043_RS05315	COG3599	regulation of cell shape
I5043_RS05325	COG2514	catechol 2,3-dioxygenase activity
I5043_RS05345	COG0564	pseudouridine synthase activity
I5043_RS05355	COG2233	PERMEase
I5043_RS05400	COG1293	RNA-binding protein homologous to eukaryotic snRNP
I5043_RS05415	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I5043_RS05420	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I5043_RS05430	COG2314	TM2 domain
I5043_RS05445	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I5043_RS05445	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I5043_RS05455	COG0631	protein serine/threonine phosphatase activity
I5043_RS05470	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I5043_RS05485	COG1302	Protein conserved in bacteria
I5043_RS05530	COG1196	nuclear chromosome segregation
I5043_RS05535	COG0552	protein localization to endoplasmic reticulum
I5043_RS05545	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I5043_RS05600	COG2348	transferase activity, transferring amino-acyl groups
I5043_RS05605	COG0758	DNA mediated transformation
I5043_RS05700	COG0195	Participates in both transcription termination and antitermination
I5043_RS05705	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I5043_RS05730	COG0196	riboflavin kinase activity
I5043_RS05755	COG2188	Transcriptional regulator
I5043_RS05760	COG0612	Peptidase, M16
I5043_RS05765	COG0612	Peptidase, M16
I5043_RS05770	COG0300	oxidoreductase activity
I5043_RS05790	COG1058	Belongs to the CinA family
I5043_RS05790	COG1546	Belongs to the CinA family
I5043_RS05810	COG1692	metallophosphoesterase
I5043_RS05815	COG0674	pyruvate-flavodoxin oxidoreductase activity
I5043_RS05815	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I5043_RS05820	COG1013	pyruvate-flavodoxin oxidoreductase activity
I5043_RS05855	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I5043_RS05860	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I5043_RS05885	COG1923	regulation of RNA biosynthetic process
I5043_RS05895	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I5043_RS05900	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
I5043_RS05905	COG0789	Transcriptional regulator
I5043_RS05995	COG1131	(ABC) transporter
I5043_RS06010	COG2197	response regulator
I5043_RS06020	COG1525	nuclease
I5043_RS06035	COG0527	aspartate kinase activity
I5043_RS06040	COG0460	homoserine dehydrogenase
I5043_RS06045	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I5043_RS06070	COG0833	amino acid
I5043_RS06095	COG2340	Cysteine-rich secretory protein family
I5043_RS06130	COG4846	Membrane protein involved in cytochrome C biogenesis
I5043_RS06150	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I5043_RS06160	COG0824	Thioesterase
I5043_RS06180	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I5043_RS06185	COG1115	amino acid carrier protein
I5043_RS06200	COG0628	permease
I5043_RS06225	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I5043_RS06235	COG1363	Peptidase, m42
I5043_RS06240	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I5043_RS06245	COG0512	Glutamine amidotransferase of anthranilate synthase
I5043_RS06330	COG0704	Plays a role in the regulation of phosphate uptake
I5043_RS06340	COG0581	inorganic phosphate transmembrane transporter activity
I5043_RS06345	COG0573	inorganic phosphate transmembrane transporter activity
I5043_RS06365	COG0488	(ABC) transporter
I5043_RS06370	COG0527	aspartate kinase activity
I5043_RS06375	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I5043_RS06410	COG2808	Putative FMN-binding domain
I5043_RS06450	COG4548	von Willebrand factor, type A
I5043_RS06455	COG0714	Associated with various cellular activities
I5043_RS06495	COG0671	phosphoesterase, PA-phosphatase related
I5043_RS06570	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I5043_RS06590	COG0531	amino acid
I5043_RS06605	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I5043_RS06610	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I5043_RS06625	COG0116	Belongs to the methyltransferase superfamily
I5043_RS06660	COG4499	WXG100 protein secretion system (Wss), protein YukC
I5043_RS06660	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I5043_RS06670	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I5043_RS06675	COG3935	DnaD domain protein
I5043_RS06700	COG0438	transferase activity, transferring glycosyl groups
I5043_RS06705	COG1694	Mazg nucleotide pyrophosphohydrolase
I5043_RS06710	COG2738	Putative neutral zinc metallopeptidase
I5043_RS06715	COG4347	Protein of unknown function (DUF1405)
I5043_RS06750	COG0142	geranyltranstransferase activity
I5043_RS06805	COG0492	ferredoxin-NADP+ reductase activity
I5043_RS06820	COG0514	ATP-dependent DNA helicase (RecQ)
I5043_RS06830	COG1141	Ferredoxin
I5043_RS06850	COG5002	protein histidine kinase activity
I5043_RS06855	COG0745	RESPONSE REGULATOR receiver
I5043_RS06860	COG1187	pseudouridine synthase activity
I5043_RS06885	COG0735	belongs to the Fur family
I5043_RS06890	COG0494	nUDIX hydrolase
I5043_RS06895	COG0667	Aldo Keto reductase
I5043_RS06905	COG4221	oxidoreductase activity
I5043_RS06920	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I5043_RS06930	COG0366	Alpha amylase catalytic
I5043_RS06935	COG1609	Transcriptional regulator
I5043_RS06955	COG2195	Cleaves the N-terminal amino acid of tripeptides
I5043_RS06965	COG4129	membrane
I5043_RS06975	COG0508	dehydrogenase complex catalyzes the overall conversion of
I5043_RS06980	COG0022	dehydrogenase e1 component
I5043_RS06985	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I5043_RS06990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I5043_RS06995	COG0497	DNA recombination
I5043_RS07025	COG1302	Protein conserved in bacteria
I5043_RS07030	COG0439	Biotin carboxylase
I5043_RS07035	COG0511	ligase activity, forming carbon-carbon bonds
I5043_RS07045	COG0006	proline dipeptidase activity
I5043_RS07060	COG0095	Lipoate-protein ligase
I5043_RS07065	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I5043_RS07110	COG4537	Required for transformation and DNA binding
I5043_RS07115	COG1459	type II secretion system
I5043_RS07120	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I5043_RS07125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5043_RS07130	COG0011	TIGRFAM Protein of
I5043_RS07135	COG1940	carbohydrate kinase activity
I5043_RS07140	COG4483	Protein conserved in bacteria
I5043_RS07150	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I5043_RS07160	COG0768	penicillin binding
I5043_RS07175	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5043_RS07180	COG1121	(ABC) transporter
I5043_RS07190	COG0513	Belongs to the DEAD box helicase family
I5043_RS07200	COG2384	SAM-dependent methyltransferase
I5043_RS07220	COG0517	IMP dehydrogenase activity
I5043_RS07240	COG0295	cytidine deaminase activity
I5043_RS07255	COG1702	phosphate starvation-inducible protein PhoH
I5043_RS07270	COG1030	water channel activity
I5043_RS07280	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I5043_RS07285	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I5043_RS07315	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I5043_RS07330	COG1466	dna polymerase III delta subunit
I5043_RS07335	COG2333	competence protein COMEC
I5043_RS07335	COG0658	competence protein
I5043_RS07340	COG2131	deaminase
I5043_RS07350	COG2226	methyltransferase
I5043_RS07355	COG0799	negative regulation of ribosome biogenesis
I5043_RS07360	COG1713	HD superfamily hydrolase involved in NAD metabolism
I5043_RS07370	COG1534	Rna-binding protein
I5043_RS07380	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I5043_RS07385	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I5043_RS07405	COG3177	Filamentation induced by cAMP protein fic
I5043_RS07410	COG1914	H( )-stimulated, divalent metal cation uptake system
I5043_RS07420	COG0439	Biotin carboxylase
I5043_RS07425	COG0511	ligase activity, forming carbon-carbon bonds
I5043_RS07430	COG1984	allophanate hydrolase subunit 2
I5043_RS07435	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I5043_RS07450	COG0826	peptidase U32
I5043_RS07455	COG0826	peptidase U32
I5043_RS07485	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I5043_RS07500	COG1104	cysteine desulfurase activity
I5043_RS07505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5043_RS07515	COG3237	CsbD-like
I5043_RS07520	COG1959	2 iron, 2 sulfur cluster binding
I5043_RS07525	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I5043_RS07530	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I5043_RS07575	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I5043_RS07575	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I5043_RS07580	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I5043_RS07580	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I5043_RS07585	COG1862	Preprotein translocase
I5043_RS07625	COG2868	ribosomal protein
I5043_RS07670	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I5043_RS07675	COG0285	dihydrofolate synthase activity
I5043_RS07685	COG2818	Glycosylase
I5043_RS07725	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I5043_RS07760	COG4112	unkown
I5043_RS07780	COG0833	amino acid
I5043_RS07795	COG1484	DNA-dependent DNA replication
I5043_RS07825	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I5043_RS07825	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I5043_RS07835	COG5002	protein histidine kinase activity
I5043_RS07840	COG0745	RESPONSE REGULATOR receiver
I5043_RS07850	COG0372	Belongs to the citrate synthase family
I5043_RS07855	COG1113	amino acid transport
I5043_RS07880	COG0281	malic enzyme
I5043_RS07890	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I5043_RS07895	COG4109	DRTGG domain
I5043_RS07935	COG0827	DNA restriction-modification system
I5043_RS07945	COG0730	response to heat
I5043_RS07955	COG1104	cysteine desulfurase activity
I5043_RS07965	COG1956	GAF domain-containing protein
I5043_RS07975	COG0584	glycerophosphoryl diester phosphodiesterase
I5043_RS07980	COG1764	response to oxidative stress
I5043_RS07985	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I5043_RS07990	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I5043_RS08005	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5043_RS08005	COG1263	PTS System
I5043_RS08010	COG0204	Acyl-transferase
I5043_RS08015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I5043_RS08050	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I5043_RS08055	COG0454	-acetyltransferase
I5043_RS08075	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I5043_RS08075	COG1605	Chorismate mutase
I5043_RS08100	COG1674	ftsk spoiiie
I5043_RS08105	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I5043_RS08115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I5043_RS08120	COG1363	Peptidase, m42
I5043_RS08130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5043_RS08140	COG0510	thiamine kinase activity
I5043_RS08160	COG1187	pseudouridine synthase activity
I5043_RS08165	COG2244	polysaccharide biosynthetic process
I5043_RS08170	COG2081	HI0933 family
I5043_RS08190	COG2814	Major facilitator Superfamily
I5043_RS08195	COG1242	4 iron, 4 sulfur cluster binding
I5043_RS08200	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I5043_RS08210	COG2267	carboxylic ester hydrolase activity
I5043_RS08240	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I5043_RS08240	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I5043_RS08265	COG4193	domain, Protein
I5043_RS08265	COG3266	domain, Protein
I5043_RS08265	COG5632	N-Acetylmuramoyl-L-alanine amidase
I5043_RS08295	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I5043_RS08315	COG0656	L-ascorbic acid biosynthetic process
I5043_RS08335	COG1506	peptidase
I5043_RS08340	COG2816	NAD+ diphosphatase activity
I5043_RS08390	COG1131	(ABC) transporter
I5043_RS08505	COG1131	(ABC) transporter
I5043_RS08615	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I5043_RS08645	COG1131	(ABC) transporter
I5043_RS08650	COG0537	adenosine 5'-monophosphoramidase activity
I5043_RS08680	COG0420	3'-5' exonuclease activity
I5043_RS08705	COG2197	response regulator
I5043_RS08710	COG2203	Gaf domain
I5043_RS08710	COG4585	Histidine kinase
I5043_RS08715	COG0564	pseudouridine synthase activity
I5043_RS08750	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I5043_RS08755	COG1126	abc transporter atp-binding protein
I5043_RS08760	COG0765	amino acid transport
I5043_RS08920	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I5043_RS08925	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I5043_RS08935	COG4129	membrane
I5043_RS08955	COG1194	a g-specific adenine glycosylase
I5043_RS08960	COG1988	membrane-bound metal-dependent
I5043_RS08970	COG1388	LysM domain
I5043_RS08970	COG1134	teichoic acid transport
I5043_RS09005	COG0535	radical SAM domain protein
I5043_RS09010	COG1607	acyl-coa hydrolase
I5043_RS09015	COG2309	aminopeptidase activity
I5043_RS09035	COG1295	ribonuclease BN
I5043_RS09040	COG2197	response regulator
I5043_RS09150	COG1733	regulation of RNA biosynthetic process
I5043_RS09160	COG4851	CamS sex pheromone cAM373 precursor
I5043_RS09180	COG4496	protein, YerC YecD
I5043_RS09215	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I5043_RS09225	COG0077	Prephenate dehydratase
I5043_RS09245	COG1335	isochorismatase
I5043_RS09260	COG1012	belongs to the aldehyde dehydrogenase family
I5043_RS09310	COG1131	(ABC) transporter
I5043_RS09325	COG1725	Transcriptional regulator
I5043_RS09370	COG1388	LysM domain
I5043_RS09370	COG5632	N-Acetylmuramoyl-L-alanine amidase
I5043_RS09535	COG0756	dUTP diphosphatase activity
I5043_RS09585	COG1484	DNA-dependent DNA replication
I5043_RS09655	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I5043_RS09705	COG0156	8-amino-7-oxononanoate synthase activity
I5043_RS09710	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I5043_RS09785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5043_RS09790	COG1621	beta-fructofuranosidase activity
I5043_RS09795	COG1609	Transcriptional regulator
I5043_RS09800	COG0004	ammonium transporteR
I5043_RS09805	COG0425	Belongs to the sulfur carrier protein TusA family
I5043_RS09810	COG2391	methyltransferase activity
I5043_RS09820	COG0488	(ABC) transporter
I5043_RS09830	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I5043_RS09840	COG0456	acetyltransferase
I5043_RS09845	COG1214	PFAM Peptidase M22, glycoprotease
I5043_RS09850	COG0802	atpase or kinase
I5043_RS09865	COG0028	Belongs to the TPP enzyme family
I5043_RS09940	COG2183	response to ionizing radiation
I5043_RS09945	COG1191	sigma factor activity
I5043_RS09955	COG1366	Belongs to the anti-sigma-factor antagonist family
I5043_RS09960	COG2208	phosphoserine phosphatase activity
I5043_RS09990	COG3428	Bacterial PH domain
I5043_RS10020	COG2205	protein histidine kinase activity
I5043_RS10025	COG0745	RESPONSE REGULATOR receiver
I5043_RS10035	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I5043_RS10045	COG0772	Belongs to the SEDS family
I5043_RS10060	COG1937	Protein conserved in bacteria
I5043_RS10070	COG1418	mRNA catabolic process
I5043_RS10105	COG0629	single-stranded DNA binding
I5043_RS10175	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I5043_RS10200	COG0009	L-threonylcarbamoyladenylate synthase
I5043_RS10205	COG2890	protein-(glutamine-N5) methyltransferase activity
I5043_RS10225	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I5043_RS10265	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5043_RS10310	COG0813	purine-nucleoside phosphorylase activity
I5043_RS10315	COG0783	Belongs to the Dps family
I5043_RS10335	COG1482	cell wall glycoprotein biosynthetic process
I5043_RS10340	COG0702	epimerase
I5043_RS10345	COG0640	Transcriptional regulator
I5043_RS10375	COG0561	phosphatase activity
I5043_RS10380	COG1119	ATPase activity
I5043_RS10385	COG0210	DNA helicase
I5043_RS10405	COG3711	transcriptional antiterminator
I5043_RS10435	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I5043_RS10495	COG0489	protein tyrosine kinase activity
I5043_RS10500	COG2814	Major facilitator Superfamily
I5043_RS10515	COG1272	protein, Hemolysin III
I5043_RS10525	COG1988	membrane-bound metal-dependent
I5043_RS10535	COG3314	Sporulation integral membrane protein YlbJ
I5043_RS10540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5043_RS10545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5043_RS10550	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I5043_RS10560	COG3457	Alanine racemase
I5043_RS10565	COG4264	IucA IucC family
I5043_RS10570	COG2814	Major facilitator Superfamily
I5043_RS10595	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I5043_RS10605	COG2130	NADP-dependent
I5043_RS10670	COG0656	L-ascorbic acid biosynthetic process
I5043_RS10675	COG0789	Transcriptional regulator
I5043_RS10685	COG5492	domain, Protein
I5043_RS10705	COG3527	Alpha-acetolactate decarboxylase
I5043_RS10710	COG0028	Belongs to the TPP enzyme family
I5043_RS10795	COG0201	protein transport
I5043_RS10910	COG2252	PERMEase
I5043_RS10955	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5043_RS11015	COG1763	Mo-molybdopterin cofactor biosynthetic process
I5043_RS11035	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I5043_RS11040	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I5043_RS11045	COG4149	molybdate abc transporter
I5043_RS11050	COG0725	ABC transporter, periplasmic molybdate-binding protein
I5043_RS11065	COG1268	BioY protein
I5043_RS11080	COG1960	acyl-CoA dehydrogenase activity
I5043_RS11085	COG4413	Urea transporter
I5043_RS11145	COG3942	CHAP domain
I5043_RS11155	COG1757	Na H antiporter
I5043_RS11170	COG3942	CHAP domain
I5043_RS11235	COG1113	amino acid transport
I5043_RS11255	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5043_RS11260	COG0385	Bile acid
I5043_RS11270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5043_RS11270	COG1263	PTS System
I5043_RS11275	COG1737	Transcriptional regulator
I5043_RS11295	COG1028	Short-chain dehydrogenase reductase Sdr
I5043_RS11300	COG1473	amidohydrolase
I5043_RS11315	COG0583	DNA-binding transcription factor activity
I5043_RS11340	COG2258	MOSC domain
I5043_RS11360	COG1668	transmembrane transport
I5043_RS11365	COG4152	abc transporter atp-binding protein
I5043_RS11370	COG3152	Membrane
I5043_RS11380	COG0786	glutamate:sodium symporter activity
I5043_RS11390	COG0598	Magnesium transport protein CorA
I5043_RS11405	COG0657	acetylesterase activity
I5043_RS11415	COG2814	Major facilitator Superfamily
I5043_RS11420	COG1566	PFAM secretion protein HlyD family protein
I5043_RS11430	COG2814	Major facilitator Superfamily
I5043_RS11490	COG1131	(ABC) transporter
I5043_RS11505	COG1620	l-lactate permease
I5043_RS11525	COG0604	alcohol dehydrogenase
I5043_RS11550	COG1511	domain protein
I5043_RS11565	COG1263	PTS System
I5043_RS11565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5043_RS11580	COG3871	stress protein (general stress protein 26)
I5043_RS11620	COG0789	Transcriptional regulator
I5043_RS11640	COG2181	nitrate reductase activity
I5043_RS11650	COG1140	nitrate reductase beta subunit
I5043_RS11655	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I5043_RS11665	COG2146	nitrite reductase [NAD(P)H] activity
I5043_RS11670	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I5043_RS11680	COG0454	-acetyltransferase
I5043_RS11685	COG2116	formate transmembrane transporter activity
I5043_RS11700	COG0803	Belongs to the bacterial solute-binding protein 9 family
I5043_RS11700	COG3443	Belongs to the bacterial solute-binding protein 9 family
I5043_RS11735	COG1126	abc transporter atp-binding protein
I5043_RS11740	COG0765	amino acid transport
I5043_RS11745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5043_RS11765	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I5043_RS11805	COG0156	8-amino-7-oxononanoate synthase activity
I5043_RS11815	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I5043_RS11820	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I5043_RS11830	COG1132	(ABC) transporter
I5043_RS11835	COG1132	(ABC) transporter
I5043_RS11835	COG2375	cellular response to nickel ion
I5043_RS11850	COG1929	Belongs to the glycerate kinase type-1 family
I5043_RS11860	COG2814	Major facilitator Superfamily
I5043_RS11880	COG1113	amino acid transport
I5043_RS11890	COG0531	amino acid
I5043_RS11905	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I5043_RS11915	COG1174	glycine betaine transport
I5043_RS11925	COG1174	glycine betaine transport
I5043_RS11945	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
I5043_RS11950	COG0531	amino acid
I5043_RS11955	COG2272	Belongs to the type-B carboxylesterase lipase family
I5043_RS11960	COG2814	Major facilitator Superfamily
I5043_RS11965	COG0390	transport system, permease component
I5043_RS11970	COG4619	ABC transporter
I5043_RS11975	COG1363	Peptidase, m42
I5043_RS11990	COG4808	Protein conserved in bacteria
I5043_RS11995	COG0069	glutamate synthase activity
I5043_RS12010	COG1124	(ABC) transporter
I5043_RS12020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5043_RS12025	COG0601	transmembrane transport
I5043_RS12030	COG0747	negative chemotaxis
I5043_RS12055	COG1028	Short-chain dehydrogenase reductase Sdr
I5043_RS12060	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I5043_RS12065	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5043_RS12120	COG0494	nUDIX hydrolase
I5043_RS12175	COG1070	Carbohydrate kinase
I5043_RS12180	COG1802	Transcriptional regulator
I5043_RS12185	COG0789	Transcriptional regulator
I5043_RS12190	COG2357	RelA SpoT domain protein
I5043_RS12195	COG4876	unkown
I5043_RS12205	COG2271	Major facilitator Superfamily
I5043_RS12210	COG0586	Pfam SNARE associated Golgi protein
I5043_RS12220	COG2814	Major facilitator Superfamily
I5043_RS12225	COG1846	Transcriptional regulator
I5043_RS12230	COG1131	(ABC) transporter
I5043_RS12245	COG3949	Membrane
I5043_RS12250	COG0400	carboxylic ester hydrolase activity
I5043_RS12255	COG0346	lactoylglutathione lyase activity
I5043_RS12260	COG1846	Transcriptional regulator
I5043_RS12270	COG2514	catechol 2,3-dioxygenase activity
I5043_RS12285	COG0561	phosphatase activity
I5043_RS12290	COG1131	(ABC) transporter
I5043_RS12300	COG3764	Sortase (surface protein transpeptidase)
I5043_RS12320	COG1760	l-serine dehydratase
I5043_RS12325	COG1760	l-serine dehydratase
I5043_RS12340	COG0697	spore germination
I5043_RS12345	COG0657	acetylesterase activity
I5043_RS12365	COG0028	Belongs to the TPP enzyme family
I5043_RS12380	COG0583	DNA-binding transcription factor activity
I5043_RS12390	COG3942	CHAP domain
I5043_RS12400	COG3425	synthase
I5043_RS12405	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I5043_RS12430	COG2409	Drug exporters of the RND superfamily
I5043_RS12475	COG0436	Aminotransferase
I5043_RS12610	COG3001	Fructosamine kinase
I5043_RS12615	COG0167	dihydroorotate dehydrogenase activity
I5043_RS12665	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I5043_RS12670	COG3527	Alpha-acetolactate decarboxylase
I5043_RS12680	COG0531	amino acid
I5043_RS12710	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I5043_RS12730	COG1012	belongs to the aldehyde dehydrogenase family
I5043_RS12740	COG1510	regulation of RNA biosynthetic process
I5043_RS12745	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I5043_RS12770	COG2851	Citrate transporter
I5043_RS12780	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I5043_RS12790	COG0386	Belongs to the glutathione peroxidase family
I5043_RS12810	COG1136	(ABC) transporter
I5043_RS12815	COG2205	protein histidine kinase activity
I5043_RS12820	COG0745	RESPONSE REGULATOR receiver
I5043_RS12830	COG1785	Belongs to the alkaline phosphatase family
I5043_RS12840	COG1846	Transcriptional regulator
I5043_RS12885	COG1438	arginine binding
I5043_RS12905	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5043_RS12905	COG3711	transcriptional antiterminator
I5043_RS12910	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5043_RS12910	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5043_RS12910	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5043_RS12915	COG1482	cell wall glycoprotein biosynthetic process
I5043_RS12925	COG1705	Flagellar rod assembly protein muramidase FlgJ
I5043_RS12925	COG3942	CHAP domain
I5043_RS12935	COG3433	isochorismatase activity
I5043_RS12935	COG1535	isochorismatase
I5043_RS12950	COG0438	transferase activity, transferring glycosyl groups
I5043_RS12965	COG1073	alpha beta
I5043_RS12985	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I5043_RS13025	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I5043_RS13115	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I5043_RS13170	COG0471	metal ion transport
I5043_RS13175	COG2962	Rard protein
I5043_RS13185	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
I5043_RS13200	COG1136	(ABC) transporter
I5043_RS13205	COG0577	efflux transmembrane transporter activity
I5043_RS13215	COG1278	Cold shock
I5043_RS13235	COG1475	DNA binding