locus-tag	class	description
HMPRNC0000_RS00015	COG2501	S4 domain
HMPRNC0000_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HMPRNC0000_RS00060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HMPRNC0000_RS00070	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HMPRNC0000_RS00080	COG0305	Participates in initiation and elongation during chromosome replication
HMPRNC0000_RS00110	COG4863	YycH protein
HMPRNC0000_RS00120	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HMPRNC0000_RS00125	COG0737	Belongs to the 5'-nucleotidase family
HMPRNC0000_RS00185	COG0730	response to heat
HMPRNC0000_RS00195	COG2210	Belongs to the sulfur carrier protein TusA family
HMPRNC0000_RS00200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HMPRNC0000_RS00205	COG1846	Transcriptional regulator
HMPRNC0000_RS00205	COG1940	carbohydrate kinase activity
HMPRNC0000_RS00225	COG2030	dehydratase
HMPRNC0000_RS00230	COG0584	glycerophosphoryl diester phosphodiesterase
HMPRNC0000_RS00240	COG3425	synthase
HMPRNC0000_RS00270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HMPRNC0000_RS00275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HMPRNC0000_RS00375	COG0823	Involved in the tonB-independent uptake of proteins
HMPRNC0000_RS00420	COG1473	amidohydrolase
HMPRNC0000_RS00440	COG4716	Myosin-crossreactive antigen
HMPRNC0000_RS00445	COG0697	spore germination
HMPRNC0000_RS00460	COG1620	l-lactate permease
HMPRNC0000_RS00480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPRNC0000_RS00495	COG2423	ornithine cyclodeaminase activity
HMPRNC0000_RS00500	COG4264	IucA IucC family
HMPRNC0000_RS00505	COG2814	Major facilitator Superfamily
HMPRNC0000_RS00510	COG4264	IucA IucC family
HMPRNC0000_RS00515	COG4264	IucA IucC family
HMPRNC0000_RS00525	COG0019	diaminopimelate decarboxylase activity
HMPRNC0000_RS00530	COG1475	DNA binding
HMPRNC0000_RS00555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HMPRNC0000_RS00560	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HMPRNC0000_RS00565	COG0438	transferase activity, transferring glycosyl groups
HMPRNC0000_RS00595	COG0813	purine-nucleoside phosphorylase activity
HMPRNC0000_RS00600	COG2814	Major facilitator Superfamily
HMPRNC0000_RS00620	COG3639	organic phosphonate transmembrane transporter activity
HMPRNC0000_RS00640	COG0737	Belongs to the 5'-nucleotidase family
HMPRNC0000_RS00655	COG1012	belongs to the aldehyde dehydrogenase family
HMPRNC0000_RS00655	COG1454	alcohol dehydrogenase
HMPRNC0000_RS00690	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HMPRNC0000_RS00720	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HMPRNC0000_RS00730	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HMPRNC0000_RS00735	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HMPRNC0000_RS00745	COG2832	Protein of unknown function (DUF454)
HMPRNC0000_RS00785	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HMPRNC0000_RS00790	COG1960	acyl-CoA dehydrogenase activity
HMPRNC0000_RS00795	COG5609	conserved protein (DUF2294)
HMPRNC0000_RS00845	COG1114	Component of the transport system for branched-chain amino acids
HMPRNC0000_RS00850	COG1335	isochorismatase
HMPRNC0000_RS00855	COG3961	Belongs to the TPP enzyme family
HMPRNC0000_RS00885	COG1737	Transcriptional regulator
HMPRNC0000_RS00910	COG1136	(ABC) transporter
HMPRNC0000_RS00915	COG1136	(ABC) transporter
HMPRNC0000_RS00915	COG0577	efflux transmembrane transporter activity
HMPRNC0000_RS00935	COG1131	(ABC) transporter
HMPRNC0000_RS00950	COG0601	transmembrane transport
HMPRNC0000_RS00955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMPRNC0000_RS00965	COG0405	Gamma-glutamyltransferase
HMPRNC0000_RS00985	COG3842	ATPase activity
HMPRNC0000_RS00995	COG1175	transmembrane transport
HMPRNC0000_RS01000	COG3833	ABC-type maltose transport systems, permease component
HMPRNC0000_RS01005	COG0673	inositol 2-dehydrogenase activity
HMPRNC0000_RS01010	COG0673	inositol 2-dehydrogenase activity
HMPRNC0000_RS01090	COG0183	Belongs to the thiolase family
HMPRNC0000_RS01100	COG1960	acyl-CoA dehydrogenase activity
HMPRNC0000_RS01105	COG0318	PFAM AMP-dependent synthetase and ligase
HMPRNC0000_RS01125	COG3189	MarR family transcriptional regulator
HMPRNC0000_RS01150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HMPRNC0000_RS01150	COG2190	(PTS) system
HMPRNC0000_RS01150	COG1263	PTS System
HMPRNC0000_RS01155	COG1957	nucleoside hydrolase
HMPRNC0000_RS01175	COG3414	Phosphotransferase system galactitol-specific IIB component
HMPRNC0000_RS01180	COG3775	system Galactitol-specific IIC component
HMPRNC0000_RS01185	COG1063	alcohol dehydrogenase
HMPRNC0000_RS01195	COG1063	alcohol dehydrogenase
HMPRNC0000_RS01205	COG1063	alcohol dehydrogenase
HMPRNC0000_RS01215	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HMPRNC0000_RS01225	COG1063	alcohol dehydrogenase
HMPRNC0000_RS01230	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HMPRNC0000_RS01265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HMPRNC0000_RS01270	COG1263	PTS System
HMPRNC0000_RS01270	COG2190	(PTS) system
HMPRNC0000_RS01270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HMPRNC0000_RS01275	COG2723	6-phospho-beta-galactosidase activity
HMPRNC0000_RS01280	COG2226	methyltransferase
HMPRNC0000_RS01365	COG3942	CHAP domain
HMPRNC0000_RS01365	COG1388	LysM domain
HMPRNC0000_RS01505	COG1114	Component of the transport system for branched-chain amino acids
HMPRNC0000_RS01520	COG0577	efflux transmembrane transporter activity
HMPRNC0000_RS01550	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HMPRNC0000_RS01580	COG3314	Sporulation integral membrane protein YlbJ
HMPRNC0000_RS01605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HMPRNC0000_RS01630	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HMPRNC0000_RS01645	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HMPRNC0000_RS01675	COG0346	lactoylglutathione lyase activity
HMPRNC0000_RS01680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HMPRNC0000_RS01685	COG0431	NADPH-dependent FMN reductase
HMPRNC0000_RS01695	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HMPRNC0000_RS01700	COG2822	iron ion transport
HMPRNC0000_RS01710	COG0672	)-iron permease
HMPRNC0000_RS01720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HMPRNC0000_RS01730	COG1476	TRANSCRIPTIONal
HMPRNC0000_RS01740	COG1131	(ABC) transporter
HMPRNC0000_RS01770	COG0646	methionine synthase
HMPRNC0000_RS01770	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HMPRNC0000_RS01780	COG0626	cystathionine gamma-synthase activity
HMPRNC0000_RS01790	COG1475	DNA binding
HMPRNC0000_RS01795	COG0668	transmembrane transport
HMPRNC0000_RS01800	COG4481	Protein conserved in bacteria
HMPRNC0000_RS01805	COG0012	GTP binding
HMPRNC0000_RS01995	COG1683	Conserved Protein
HMPRNC0000_RS02170	COG0523	cobalamin synthesis protein
HMPRNC0000_RS02195	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HMPRNC0000_RS02205	COG5609	conserved protein (DUF2294)
HMPRNC0000_RS02220	COG1647	Serine aminopeptidase, S33
HMPRNC0000_RS02230	COG0733	neurotransmitter:sodium symporter activity
HMPRNC0000_RS02235	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HMPRNC0000_RS02240	COG0626	cystathionine gamma-synthase activity
HMPRNC0000_RS02250	COG2011	ABC-type metal ion transport system permease component
HMPRNC0000_RS02255	COG1464	Belongs to the NlpA lipoprotein family
HMPRNC0000_RS02295	COG0069	glutamate synthase activity
HMPRNC0000_RS02295	COG0067	glutamate synthase
HMPRNC0000_RS02295	COG0070	glutamate synthase
HMPRNC0000_RS02300	COG0493	'glutamate synthase
HMPRNC0000_RS02310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HMPRNC0000_RS02310	COG1263	PTS System
HMPRNC0000_RS02315	COG0366	Alpha amylase catalytic
HMPRNC0000_RS02320	COG2188	Transcriptional regulator
HMPRNC0000_RS02340	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HMPRNC0000_RS02380	COG1982	Orn Lys Arg decarboxylase major
HMPRNC0000_RS02390	COG3870	Protein conserved in bacteria
HMPRNC0000_RS02395	COG0470	DNA polymerase III
HMPRNC0000_RS02400	COG1774	PSP1 C-terminal conserved region
HMPRNC0000_RS02410	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HMPRNC0000_RS02420	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HMPRNC0000_RS02430	COG0084	hydrolase, TatD family'
HMPRNC0000_RS02435	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HMPRNC0000_RS02445	COG4466	Protein conserved in bacteria
HMPRNC0000_RS02455	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HMPRNC0000_RS02460	COG0251	oxidation-reduction process
HMPRNC0000_RS02500	COG2244	polysaccharide biosynthetic process
HMPRNC0000_RS02505	COG3956	TIGRFAM MazG family protein
HMPRNC0000_RS02510	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HMPRNC0000_RS02520	COG1098	S1 RNA binding domain
HMPRNC0000_RS02535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HMPRNC0000_RS02560	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HMPRNC0000_RS02670	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HMPRNC0000_RS02685	COG3880	PFAM UvrB UvrC protein
HMPRNC0000_RS02700	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HMPRNC0000_RS02705	COG4956	integral membrane protein (PIN domain superfamily)
HMPRNC0000_RS02725	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HMPRNC0000_RS02785	COG2813	Specifically methylates the guanine in position
HMPRNC0000_RS02860	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HMPRNC0000_RS02865	COG1428	Deoxynucleoside kinase
HMPRNC0000_RS02880	COG0561	phosphatase activity
HMPRNC0000_RS02940	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HMPRNC0000_RS03040	COG0095	Lipoate-protein ligase
HMPRNC0000_RS03045	COG0083	homoserine kinase activity
HMPRNC0000_RS03070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HMPRNC0000_RS03155	COG0667	Aldo Keto reductase
HMPRNC0000_RS03160	COG0655	NAD(P)H dehydrogenase (quinone) activity
HMPRNC0000_RS03170	COG1078	dGTPase activity
HMPRNC0000_RS03205	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HMPRNC0000_RS03210	COG4139	cobalamin transport
HMPRNC0000_RS03260	COG4974	Belongs to the 'phage' integrase family
HMPRNC0000_RS03305	COG0803	Belongs to the bacterial solute-binding protein 9 family
HMPRNC0000_RS03310	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HMPRNC0000_RS03315	COG1121	(ABC) transporter
HMPRNC0000_RS03320	COG1321	iron dependent repressor
HMPRNC0000_RS03340	COG1682	transport, permease protein
HMPRNC0000_RS03345	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HMPRNC0000_RS03350	COG1216	Glycosyl transferase, family 2
HMPRNC0000_RS03355	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HMPRNC0000_RS03365	COG1132	(ABC) transporter
HMPRNC0000_RS03370	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HMPRNC0000_RS03380	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HMPRNC0000_RS03385	COG1120	ATPase activity
HMPRNC0000_RS03390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPRNC0000_RS03395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPRNC0000_RS03400	COG2376	Dihydroxyacetone kinase
HMPRNC0000_RS03410	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HMPRNC0000_RS03420	COG3949	Membrane
HMPRNC0000_RS03440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HMPRNC0000_RS03455	COG1136	(ABC) transporter
HMPRNC0000_RS03460	COG0577	efflux transmembrane transporter activity
HMPRNC0000_RS03465	COG1392	Phosphate transport regulator
HMPRNC0000_RS03470	COG0306	phosphate transporter
HMPRNC0000_RS03475	COG3942	CHAP domain
HMPRNC0000_RS03475	COG1388	LysM domain
HMPRNC0000_RS03485	COG4977	sequence-specific DNA binding
HMPRNC0000_RS03485	COG1917	Cupin 2, conserved barrel domain protein
HMPRNC0000_RS03520	COG2814	Major facilitator Superfamily
HMPRNC0000_RS03525	COG2839	Protein conserved in bacteria
HMPRNC0000_RS03555	COG1611	Belongs to the LOG family
HMPRNC0000_RS03580	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HMPRNC0000_RS03590	COG0523	cobalamin synthesis protein
HMPRNC0000_RS03595	COG4989	oxidoreductase activity
HMPRNC0000_RS03605	COG0471	metal ion transport
HMPRNC0000_RS03610	COG0415	Belongs to the DNA photolyase family
HMPRNC0000_RS03645	COG1349	DNA-binding transcription factor activity
HMPRNC0000_RS03650	COG1105	Belongs to the carbohydrate kinase PfkB family
HMPRNC0000_RS03655	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HMPRNC0000_RS03655	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HMPRNC0000_RS03655	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HMPRNC0000_RS03660	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HMPRNC0000_RS03665	COG1253	flavin adenine dinucleotide binding
HMPRNC0000_RS03670	COG0656	L-ascorbic acid biosynthetic process
HMPRNC0000_RS03675	COG0463	Glycosyl transferase, family 2
HMPRNC0000_RS03710	COG0720	synthase
HMPRNC0000_RS03720	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HMPRNC0000_RS03720	COG0512	Glutamine amidotransferase of anthranilate synthase
HMPRNC0000_RS03725	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HMPRNC0000_RS03755	COG0488	(ABC) transporter
HMPRNC0000_RS03760	COG0514	ATP-dependent DNA helicase (RecQ)
HMPRNC0000_RS03765	COG1125	glycine betaine transport
HMPRNC0000_RS03765	COG0517	IMP dehydrogenase activity
HMPRNC0000_RS03770	COG1174	glycine betaine transport
HMPRNC0000_RS03795	COG3104	oligopeptide transport
HMPRNC0000_RS03825	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HMPRNC0000_RS03830	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HMPRNC0000_RS03840	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPRNC0000_RS03845	COG4605	iron ion homeostasis
HMPRNC0000_RS03850	COG4604	ABC transporter, ATP-binding protein
HMPRNC0000_RS03855	COG4607	ABC-type enterochelin transport system periplasmic component
HMPRNC0000_RS03910	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HMPRNC0000_RS03915	COG1739	Uncharacterized protein family UPF0029
HMPRNC0000_RS03925	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HMPRNC0000_RS03930	COG1040	competence protein
HMPRNC0000_RS03960	COG1388	LysM domain
HMPRNC0000_RS03960	COG3942	CHAP domain
HMPRNC0000_RS04015	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HMPRNC0000_RS04080	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HMPRNC0000_RS04090	COG0557	exoribonuclease II activity
HMPRNC0000_RS04140	COG3266	domain, Protein
HMPRNC0000_RS04140	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HMPRNC0000_RS04165	COG1278	Cold shock
HMPRNC0000_RS04205	COG0406	alpha-ribazole phosphatase activity
HMPRNC0000_RS04210	COG1279	arginine transmembrane transporter activity
HMPRNC0000_RS04235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HMPRNC0000_RS04240	COG1393	Belongs to the ArsC family
HMPRNC0000_RS04255	COG3878	Protein conserved in bacteria
HMPRNC0000_RS04265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HMPRNC0000_RS04280	COG2011	ABC-type metal ion transport system permease component
HMPRNC0000_RS04285	COG1464	Belongs to the NlpA lipoprotein family
HMPRNC0000_RS04290	COG0582	viral genome integration into host DNA
HMPRNC0000_RS04385	COG5484	DNA packaging
HMPRNC0000_RS04385	COG3728	DNA packaging
HMPRNC0000_RS04420	COG0396	ATPase activity
HMPRNC0000_RS04425	COG0719	Fe-S assembly protein
HMPRNC0000_RS04435	COG0822	iron-sulfur transferase activity
HMPRNC0000_RS04460	COG1253	flavin adenine dinucleotide binding
HMPRNC0000_RS04470	COG1801	Protein of unknown function DUF72
HMPRNC0000_RS04475	COG0730	response to heat
HMPRNC0000_RS04490	COG4470	Protein conserved in bacteria
HMPRNC0000_RS04500	COG2445	Protein of unknown function DUF86
HMPRNC0000_RS04530	COG1696	Membrane protein involved in D-alanine export
HMPRNC0000_RS04540	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HMPRNC0000_RS04545	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HMPRNC0000_RS04550	COG4837	Protein of unknown function (DUF1462)
HMPRNC0000_RS04570	COG0316	Belongs to the HesB IscA family
HMPRNC0000_RS04580	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HMPRNC0000_RS04585	COG2056	Na+-H+ antiporter family
HMPRNC0000_RS04590	COG2050	protein possibly involved in aromatic compounds catabolism
HMPRNC0000_RS04645	COG1098	S1 RNA binding domain
HMPRNC0000_RS04650	COG1902	pentaerythritol trinitrate reductase activity
HMPRNC0000_RS04665	COG0584	glycerophosphoryl diester phosphodiesterase
HMPRNC0000_RS04690	COG0398	Pfam SNARE associated Golgi protein
HMPRNC0000_RS04775	COG1881	PFAM PEBP family protein
HMPRNC0000_RS04805	COG0601	transmembrane transport
HMPRNC0000_RS04810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMPRNC0000_RS04815	COG0444	Belongs to the ABC transporter superfamily
HMPRNC0000_RS04820	COG4608	Belongs to the ABC transporter superfamily
HMPRNC0000_RS04825	COG4166	transmembrane transport
HMPRNC0000_RS04830	COG0747	negative chemotaxis
HMPRNC0000_RS04835	COG0444	Belongs to the ABC transporter superfamily
HMPRNC0000_RS04840	COG4608	Belongs to the ABC transporter superfamily
HMPRNC0000_RS04845	COG4608	Belongs to the ABC transporter superfamily
HMPRNC0000_RS04850	COG0601	transmembrane transport
HMPRNC0000_RS04885	COG1164	Oligoendopeptidase f
HMPRNC0000_RS04895	COG2346	COG2346, Truncated hemoglobins
HMPRNC0000_RS04910	COG2357	RelA SpoT domain protein
HMPRNC0000_RS04920	COG0564	pseudouridine synthase activity
HMPRNC0000_RS04925	COG2239	Acts as a magnesium transporter
HMPRNC0000_RS04930	COG0569	domain protein
HMPRNC0000_RS04930	COG0475	glutathione-regulated potassium exporter activity
HMPRNC0000_RS04950	COG1115	amino acid carrier protein
HMPRNC0000_RS04995	COG0861	Integral membrane protein TerC family
HMPRNC0000_RS05005	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HMPRNC0000_RS05010	COG0737	Belongs to the 5'-nucleotidase family
HMPRNC0000_RS05025	COG4903	ComK protein
HMPRNC0000_RS05040	COG4873	Protein conserved in bacteria
HMPRNC0000_RS05095	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HMPRNC0000_RS05105	COG2314	TM2 domain
HMPRNC0000_RS05120	COG1169	isochorismate synthase
HMPRNC0000_RS05130	COG2267	carboxylic ester hydrolase activity
HMPRNC0000_RS05160	COG3594	Acyltransferase
HMPRNC0000_RS05210	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HMPRNC0000_RS05250	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HMPRNC0000_RS05265	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HMPRNC0000_RS05310	COG4172	Belongs to the ABC transporter superfamily
HMPRNC0000_RS05315	COG4721	ABC-type cobalt transport system, permease component
HMPRNC0000_RS05340	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HMPRNC0000_RS05360	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HMPRNC0000_RS05365	COG1271	oxidase subunit
HMPRNC0000_RS05370	COG1294	oxidase, subunit
HMPRNC0000_RS05375	COG0569	domain protein
HMPRNC0000_RS05445	COG1176	ABC-type spermidine putrescine transport system, permease component I
HMPRNC0000_RS05450	COG1177	transmembrane transport
HMPRNC0000_RS05480	COG0483	inositol monophosphate 1-phosphatase activity
HMPRNC0000_RS05490	COG1217	gtp-binding protein TYPA
HMPRNC0000_RS05500	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HMPRNC0000_RS05510	COG0772	Belongs to the SEDS family
HMPRNC0000_RS05540	COG3679	Belongs to the UPF0342 family
HMPRNC0000_RS05560	COG0742	ribosomal rna small subunit methyltransferase
HMPRNC0000_RS05620	COG4509	Sortase family
HMPRNC0000_RS05635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HMPRNC0000_RS05670	COG1796	DNA polymerase
HMPRNC0000_RS05670	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HMPRNC0000_RS05695	COG2009	succinate dehydrogenase
HMPRNC0000_RS05700	COG1053	succinate dehydrogenase
HMPRNC0000_RS05705	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HMPRNC0000_RS05815	COG1288	antiporter activity
HMPRNC0000_RS05850	COG1011	Hydrolase
HMPRNC0000_RS05875	COG0768	penicillin binding
HMPRNC0000_RS05890	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HMPRNC0000_RS05910	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HMPRNC0000_RS05920	COG0762	integral membrane protein
HMPRNC0000_RS05925	COG2302	S4 RNA-binding domain
HMPRNC0000_RS05930	COG3599	regulation of cell shape
HMPRNC0000_RS05940	COG2514	catechol 2,3-dioxygenase activity
HMPRNC0000_RS05955	COG0564	pseudouridine synthase activity
HMPRNC0000_RS05965	COG2233	PERMEase
HMPRNC0000_RS06010	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HMPRNC0000_RS06025	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HMPRNC0000_RS06040	COG2314	TM2 domain
HMPRNC0000_RS06055	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HMPRNC0000_RS06055	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HMPRNC0000_RS06065	COG0631	protein serine/threonine phosphatase activity
HMPRNC0000_RS06080	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HMPRNC0000_RS06095	COG1302	Protein conserved in bacteria
HMPRNC0000_RS06140	COG1196	nuclear chromosome segregation
HMPRNC0000_RS06145	COG0552	protein localization to endoplasmic reticulum
HMPRNC0000_RS06155	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HMPRNC0000_RS06205	COG0758	DNA mediated transformation
HMPRNC0000_RS06300	COG0195	Participates in both transcription termination and antitermination
HMPRNC0000_RS06330	COG0196	riboflavin kinase activity
HMPRNC0000_RS06355	COG2188	Transcriptional regulator
HMPRNC0000_RS06360	COG0612	Peptidase, M16
HMPRNC0000_RS06365	COG0612	Peptidase, M16
HMPRNC0000_RS06370	COG0300	oxidoreductase activity
HMPRNC0000_RS06390	COG1058	Belongs to the CinA family
HMPRNC0000_RS06390	COG1546	Belongs to the CinA family
HMPRNC0000_RS06410	COG1692	metallophosphoesterase
HMPRNC0000_RS06415	COG0674	pyruvate-flavodoxin oxidoreductase activity
HMPRNC0000_RS06415	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HMPRNC0000_RS06420	COG1013	pyruvate-flavodoxin oxidoreductase activity
HMPRNC0000_RS06455	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HMPRNC0000_RS06460	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HMPRNC0000_RS06485	COG1923	regulation of RNA biosynthetic process
HMPRNC0000_RS06495	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HMPRNC0000_RS06500	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HMPRNC0000_RS06510	COG0789	Transcriptional regulator
HMPRNC0000_RS06520	COG0582	viral genome integration into host DNA
HMPRNC0000_RS06640	COG1783	phage Terminase large subunit
HMPRNC0000_RS06705	COG1131	(ABC) transporter
HMPRNC0000_RS06720	COG2197	response regulator
HMPRNC0000_RS06730	COG1525	nuclease
HMPRNC0000_RS06750	COG0460	homoserine dehydrogenase
HMPRNC0000_RS06755	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HMPRNC0000_RS06780	COG0833	amino acid
HMPRNC0000_RS06810	COG2340	Cysteine-rich secretory protein family
HMPRNC0000_RS06845	COG4846	Membrane protein involved in cytochrome C biogenesis
HMPRNC0000_RS06865	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HMPRNC0000_RS06875	COG0824	Thioesterase
HMPRNC0000_RS06905	COG1115	amino acid carrier protein
HMPRNC0000_RS06920	COG0628	permease
HMPRNC0000_RS06960	COG1363	Peptidase, m42
HMPRNC0000_RS06965	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HMPRNC0000_RS06970	COG0512	Glutamine amidotransferase of anthranilate synthase
HMPRNC0000_RS07070	COG0704	Plays a role in the regulation of phosphate uptake
HMPRNC0000_RS07090	COG0573	inorganic phosphate transmembrane transporter activity
HMPRNC0000_RS07110	COG0488	(ABC) transporter
HMPRNC0000_RS07115	COG0527	aspartate kinase activity
HMPRNC0000_RS07120	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HMPRNC0000_RS07195	COG4548	von Willebrand factor, type A
HMPRNC0000_RS07200	COG0714	Associated with various cellular activities
HMPRNC0000_RS07245	COG0671	phosphoesterase, PA-phosphatase related
HMPRNC0000_RS07315	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HMPRNC0000_RS07345	COG0531	amino acid
HMPRNC0000_RS07360	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HMPRNC0000_RS07415	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HMPRNC0000_RS07415	COG4499	WXG100 protein secretion system (Wss), protein YukC
HMPRNC0000_RS07430	COG3935	DnaD domain protein
HMPRNC0000_RS07455	COG0438	transferase activity, transferring glycosyl groups
HMPRNC0000_RS07460	COG1694	Mazg nucleotide pyrophosphohydrolase
HMPRNC0000_RS07470	COG4347	Protein of unknown function (DUF1405)
HMPRNC0000_RS07510	COG0142	geranyltranstransferase activity
HMPRNC0000_RS07555	COG0492	ferredoxin-NADP+ reductase activity
HMPRNC0000_RS07570	COG0514	ATP-dependent DNA helicase (RecQ)
HMPRNC0000_RS07580	COG1141	Ferredoxin
HMPRNC0000_RS07640	COG0745	RESPONSE REGULATOR receiver
HMPRNC0000_RS07645	COG1187	pseudouridine synthase activity
HMPRNC0000_RS07670	COG0735	belongs to the Fur family
HMPRNC0000_RS07675	COG0494	nUDIX hydrolase
HMPRNC0000_RS07680	COG0667	Aldo Keto reductase
HMPRNC0000_RS07690	COG4221	oxidoreductase activity
HMPRNC0000_RS07705	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HMPRNC0000_RS07715	COG0366	Alpha amylase catalytic
HMPRNC0000_RS07720	COG1609	Transcriptional regulator
HMPRNC0000_RS07755	COG4129	membrane
HMPRNC0000_RS07765	COG0508	dehydrogenase complex catalyzes the overall conversion of
HMPRNC0000_RS07770	COG0022	dehydrogenase e1 component
HMPRNC0000_RS07780	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HMPRNC0000_RS07785	COG0497	DNA recombination
HMPRNC0000_RS07815	COG1302	Protein conserved in bacteria
HMPRNC0000_RS07820	COG0439	Biotin carboxylase
HMPRNC0000_RS07825	COG0511	ligase activity, forming carbon-carbon bonds
HMPRNC0000_RS07860	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HMPRNC0000_RS07905	COG4537	Required for transformation and DNA binding
HMPRNC0000_RS07910	COG1459	type II secretion system
HMPRNC0000_RS07915	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HMPRNC0000_RS07920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HMPRNC0000_RS07925	COG0011	TIGRFAM Protein of
HMPRNC0000_RS07930	COG1940	carbohydrate kinase activity
HMPRNC0000_RS07935	COG4483	Protein conserved in bacteria
HMPRNC0000_RS07955	COG0768	penicillin binding
HMPRNC0000_RS07970	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HMPRNC0000_RS07975	COG1121	(ABC) transporter
HMPRNC0000_RS07985	COG0513	Belongs to the DEAD box helicase family
HMPRNC0000_RS08060	COG1030	water channel activity
HMPRNC0000_RS08070	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HMPRNC0000_RS08075	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HMPRNC0000_RS08105	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HMPRNC0000_RS08125	COG0658	competence protein
HMPRNC0000_RS08125	COG2333	competence protein COMEC
HMPRNC0000_RS08130	COG2131	deaminase
HMPRNC0000_RS08135	COG2183	response to ionizing radiation
HMPRNC0000_RS08140	COG2226	methyltransferase
HMPRNC0000_RS08145	COG0799	negative regulation of ribosome biogenesis
HMPRNC0000_RS08150	COG1713	HD superfamily hydrolase involved in NAD metabolism
HMPRNC0000_RS08160	COG1534	Rna-binding protein
HMPRNC0000_RS08205	COG1914	H( )-stimulated, divalent metal cation uptake system
HMPRNC0000_RS08215	COG0439	Biotin carboxylase
HMPRNC0000_RS08220	COG0511	ligase activity, forming carbon-carbon bonds
HMPRNC0000_RS08225	COG1984	allophanate hydrolase subunit 2
HMPRNC0000_RS08230	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HMPRNC0000_RS08250	COG0826	peptidase U32
HMPRNC0000_RS08280	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HMPRNC0000_RS08300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HMPRNC0000_RS08310	COG3237	CsbD-like
HMPRNC0000_RS08315	COG1959	2 iron, 2 sulfur cluster binding
HMPRNC0000_RS08320	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HMPRNC0000_RS08370	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HMPRNC0000_RS08370	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HMPRNC0000_RS08375	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HMPRNC0000_RS08375	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HMPRNC0000_RS08470	COG0285	dihydrofolate synthase activity
HMPRNC0000_RS08480	COG2818	Glycosylase
HMPRNC0000_RS08515	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HMPRNC0000_RS08550	COG4112	unkown
HMPRNC0000_RS08585	COG1484	DNA-dependent DNA replication
HMPRNC0000_RS08645	COG1113	amino acid transport
HMPRNC0000_RS08730	COG0827	DNA restriction-modification system
HMPRNC0000_RS08760	COG1956	GAF domain-containing protein
HMPRNC0000_RS08780	COG1764	response to oxidative stress
HMPRNC0000_RS08785	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HMPRNC0000_RS08790	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HMPRNC0000_RS08805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HMPRNC0000_RS08805	COG1263	PTS System
HMPRNC0000_RS08815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HMPRNC0000_RS08835	COG5386	Cell surface protein
HMPRNC0000_RS08855	COG0454	-acetyltransferase
HMPRNC0000_RS08905	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HMPRNC0000_RS08955	COG1187	pseudouridine synthase activity
HMPRNC0000_RS08965	COG2081	HI0933 family
HMPRNC0000_RS08985	COG2814	Major facilitator Superfamily
HMPRNC0000_RS08990	COG1242	4 iron, 4 sulfur cluster binding
HMPRNC0000_RS08995	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HMPRNC0000_RS09110	COG0656	L-ascorbic acid biosynthetic process
HMPRNC0000_RS09130	COG1506	peptidase
HMPRNC0000_RS09220	COG5492	domain, Protein
HMPRNC0000_RS09455	COG0537	adenosine 5'-monophosphoramidase activity
HMPRNC0000_RS09515	COG2197	response regulator
HMPRNC0000_RS09525	COG0564	pseudouridine synthase activity
HMPRNC0000_RS09560	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HMPRNC0000_RS09565	COG1126	abc transporter atp-binding protein
HMPRNC0000_RS09570	COG0765	amino acid transport
HMPRNC0000_RS09745	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HMPRNC0000_RS09750	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HMPRNC0000_RS09760	COG4129	membrane
HMPRNC0000_RS09785	COG1988	membrane-bound metal-dependent
HMPRNC0000_RS09830	COG0535	radical SAM domain protein
HMPRNC0000_RS09835	COG1607	acyl-coa hydrolase
HMPRNC0000_RS09840	COG2309	aminopeptidase activity
HMPRNC0000_RS09860	COG1295	ribonuclease BN
HMPRNC0000_RS09985	COG0210	DNA helicase
HMPRNC0000_RS09995	COG4496	protein, YerC YecD
HMPRNC0000_RS10035	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HMPRNC0000_RS10045	COG0077	Prephenate dehydratase
HMPRNC0000_RS10065	COG1335	isochorismatase
HMPRNC0000_RS10085	COG1012	belongs to the aldehyde dehydrogenase family
HMPRNC0000_RS10140	COG1131	(ABC) transporter
HMPRNC0000_RS10155	COG1725	Transcriptional regulator
HMPRNC0000_RS10210	COG1388	LysM domain
HMPRNC0000_RS10210	COG0860	N-Acetylmuramoyl-L-alanine amidase
HMPRNC0000_RS10230	COG5632	N-Acetylmuramoyl-L-alanine amidase
HMPRNC0000_RS10230	COG1388	LysM domain
HMPRNC0000_RS10275	COG0739	heme binding
HMPRNC0000_RS10330	COG4695	Portal protein
HMPRNC0000_RS10515	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HMPRNC0000_RS10565	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HMPRNC0000_RS10570	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HMPRNC0000_RS10575	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HMPRNC0000_RS10655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HMPRNC0000_RS10665	COG1609	Transcriptional regulator
HMPRNC0000_RS10670	COG0004	ammonium transporteR
HMPRNC0000_RS10675	COG0425	Belongs to the sulfur carrier protein TusA family
HMPRNC0000_RS10680	COG2391	methyltransferase activity
HMPRNC0000_RS10690	COG0488	(ABC) transporter
HMPRNC0000_RS10705	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HMPRNC0000_RS10715	COG0456	acetyltransferase
HMPRNC0000_RS10720	COG1214	PFAM Peptidase M22, glycoprotease
HMPRNC0000_RS10725	COG0802	atpase or kinase
HMPRNC0000_RS10740	COG0028	Belongs to the TPP enzyme family
HMPRNC0000_RS10825	COG1191	sigma factor activity
HMPRNC0000_RS10835	COG1366	Belongs to the anti-sigma-factor antagonist family
HMPRNC0000_RS10840	COG2208	phosphoserine phosphatase activity
HMPRNC0000_RS10870	COG3428	Bacterial PH domain
HMPRNC0000_RS10905	COG0745	RESPONSE REGULATOR receiver
HMPRNC0000_RS10915	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HMPRNC0000_RS10925	COG0772	Belongs to the SEDS family
HMPRNC0000_RS10940	COG1937	Protein conserved in bacteria
HMPRNC0000_RS10950	COG1418	mRNA catabolic process
HMPRNC0000_RS10995	COG0629	single-stranded DNA binding
HMPRNC0000_RS11070	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HMPRNC0000_RS11095	COG0009	L-threonylcarbamoyladenylate synthase
HMPRNC0000_RS11100	COG2890	protein-(glutamine-N5) methyltransferase activity
HMPRNC0000_RS11125	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HMPRNC0000_RS11165	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HMPRNC0000_RS11205	COG0813	purine-nucleoside phosphorylase activity
HMPRNC0000_RS11210	COG0783	Belongs to the Dps family
HMPRNC0000_RS11230	COG1482	cell wall glycoprotein biosynthetic process
HMPRNC0000_RS11235	COG0702	epimerase
HMPRNC0000_RS11240	COG0640	Transcriptional regulator
HMPRNC0000_RS11275	COG0561	phosphatase activity
HMPRNC0000_RS11280	COG1119	ATPase activity
HMPRNC0000_RS11295	COG3711	transcriptional antiterminator
HMPRNC0000_RS11325	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HMPRNC0000_RS11390	COG0489	protein tyrosine kinase activity
HMPRNC0000_RS11395	COG2814	Major facilitator Superfamily
HMPRNC0000_RS11410	COG1272	protein, Hemolysin III
HMPRNC0000_RS11420	COG1988	membrane-bound metal-dependent
HMPRNC0000_RS11430	COG3314	Sporulation integral membrane protein YlbJ
HMPRNC0000_RS11435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPRNC0000_RS11440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPRNC0000_RS11445	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HMPRNC0000_RS11460	COG4264	IucA IucC family
HMPRNC0000_RS11465	COG2814	Major facilitator Superfamily
HMPRNC0000_RS11490	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HMPRNC0000_RS11500	COG2130	NADP-dependent
HMPRNC0000_RS11570	COG0656	L-ascorbic acid biosynthetic process
HMPRNC0000_RS11575	COG0789	Transcriptional regulator
HMPRNC0000_RS11585	COG5492	domain, Protein
HMPRNC0000_RS11595	COG3527	Alpha-acetolactate decarboxylase
HMPRNC0000_RS11600	COG0028	Belongs to the TPP enzyme family
HMPRNC0000_RS11680	COG0201	protein transport
HMPRNC0000_RS11795	COG2252	PERMEase
HMPRNC0000_RS11845	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HMPRNC0000_RS11905	COG1763	Mo-molybdopterin cofactor biosynthetic process
HMPRNC0000_RS11925	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HMPRNC0000_RS11930	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HMPRNC0000_RS11935	COG4149	molybdate abc transporter
HMPRNC0000_RS11940	COG0725	ABC transporter, periplasmic molybdate-binding protein
HMPRNC0000_RS11955	COG1268	BioY protein
HMPRNC0000_RS11970	COG1960	acyl-CoA dehydrogenase activity
HMPRNC0000_RS11975	COG4413	Urea transporter
HMPRNC0000_RS12035	COG3942	CHAP domain
HMPRNC0000_RS12045	COG1757	Na H antiporter
HMPRNC0000_RS12060	COG3942	CHAP domain
HMPRNC0000_RS12135	COG1113	amino acid transport
HMPRNC0000_RS12155	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HMPRNC0000_RS12160	COG0385	Bile acid
HMPRNC0000_RS12175	COG1737	Transcriptional regulator
HMPRNC0000_RS12195	COG1028	Short-chain dehydrogenase reductase Sdr
HMPRNC0000_RS12200	COG1473	amidohydrolase
HMPRNC0000_RS12215	COG0583	DNA-binding transcription factor activity
HMPRNC0000_RS12235	COG2258	MOSC domain
HMPRNC0000_RS12255	COG1668	transmembrane transport
HMPRNC0000_RS12260	COG4152	abc transporter atp-binding protein
HMPRNC0000_RS12265	COG3152	Membrane
HMPRNC0000_RS12280	COG0786	glutamate:sodium symporter activity
HMPRNC0000_RS12290	COG0598	Magnesium transport protein CorA
HMPRNC0000_RS12305	COG0657	acetylesterase activity
HMPRNC0000_RS12315	COG2814	Major facilitator Superfamily
HMPRNC0000_RS12320	COG1566	PFAM secretion protein HlyD family protein
HMPRNC0000_RS12330	COG2814	Major facilitator Superfamily
HMPRNC0000_RS12390	COG1620	l-lactate permease
HMPRNC0000_RS12410	COG0604	alcohol dehydrogenase
HMPRNC0000_RS12415	COG0456	acetyltransferase
HMPRNC0000_RS12435	COG1511	domain protein
HMPRNC0000_RS12450	COG1263	PTS System
HMPRNC0000_RS12450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HMPRNC0000_RS12465	COG3871	stress protein (general stress protein 26)
HMPRNC0000_RS12515	COG2181	nitrate reductase activity
HMPRNC0000_RS12525	COG1140	nitrate reductase beta subunit
HMPRNC0000_RS12530	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HMPRNC0000_RS12540	COG2146	nitrite reductase [NAD(P)H] activity
HMPRNC0000_RS12545	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HMPRNC0000_RS12555	COG0454	-acetyltransferase
HMPRNC0000_RS12560	COG2116	formate transmembrane transporter activity
HMPRNC0000_RS12575	COG3443	Belongs to the bacterial solute-binding protein 9 family
HMPRNC0000_RS12575	COG0803	Belongs to the bacterial solute-binding protein 9 family
HMPRNC0000_RS12625	COG0765	amino acid transport
HMPRNC0000_RS12630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HMPRNC0000_RS12635	COG2814	Major facilitator Superfamily
HMPRNC0000_RS12650	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HMPRNC0000_RS12695	COG0156	8-amino-7-oxononanoate synthase activity
HMPRNC0000_RS12705	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HMPRNC0000_RS12710	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HMPRNC0000_RS12725	COG1132	(ABC) transporter
HMPRNC0000_RS12725	COG2375	cellular response to nickel ion
HMPRNC0000_RS12740	COG1929	Belongs to the glycerate kinase type-1 family
HMPRNC0000_RS12750	COG2814	Major facilitator Superfamily
HMPRNC0000_RS12770	COG1113	amino acid transport
HMPRNC0000_RS12780	COG0531	amino acid
HMPRNC0000_RS12795	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HMPRNC0000_RS12805	COG1174	glycine betaine transport
HMPRNC0000_RS12815	COG1174	glycine betaine transport
HMPRNC0000_RS12835	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
HMPRNC0000_RS12840	COG0531	amino acid
HMPRNC0000_RS12845	COG2272	Belongs to the type-B carboxylesterase lipase family
HMPRNC0000_RS12850	COG2814	Major facilitator Superfamily
HMPRNC0000_RS12855	COG0390	transport system, permease component
HMPRNC0000_RS12860	COG4619	ABC transporter
HMPRNC0000_RS12865	COG1363	Peptidase, m42
HMPRNC0000_RS12885	COG4808	Protein conserved in bacteria
HMPRNC0000_RS12890	COG0069	glutamate synthase activity
HMPRNC0000_RS12905	COG1124	(ABC) transporter
HMPRNC0000_RS12910	COG0444	Belongs to the ABC transporter superfamily
HMPRNC0000_RS12915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMPRNC0000_RS12920	COG0601	transmembrane transport
HMPRNC0000_RS12950	COG1028	Short-chain dehydrogenase reductase Sdr
HMPRNC0000_RS12955	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HMPRNC0000_RS12960	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HMPRNC0000_RS13015	COG0494	nUDIX hydrolase
HMPRNC0000_RS13055	COG1846	Transcriptional regulator
HMPRNC0000_RS13090	COG1070	Carbohydrate kinase
HMPRNC0000_RS13095	COG1802	Transcriptional regulator
HMPRNC0000_RS13100	COG0789	Transcriptional regulator
HMPRNC0000_RS13105	COG2357	RelA SpoT domain protein
HMPRNC0000_RS13110	COG4876	unkown
HMPRNC0000_RS13125	COG2271	Major facilitator Superfamily
HMPRNC0000_RS13130	COG0586	Pfam SNARE associated Golgi protein
HMPRNC0000_RS13140	COG2814	Major facilitator Superfamily
HMPRNC0000_RS13145	COG1846	Transcriptional regulator
HMPRNC0000_RS13160	COG1131	(ABC) transporter
HMPRNC0000_RS13180	COG0400	carboxylic ester hydrolase activity
HMPRNC0000_RS13185	COG0346	lactoylglutathione lyase activity
HMPRNC0000_RS13190	COG1846	Transcriptional regulator
HMPRNC0000_RS13200	COG2514	catechol 2,3-dioxygenase activity
HMPRNC0000_RS13215	COG0561	phosphatase activity
HMPRNC0000_RS13220	COG1131	(ABC) transporter
HMPRNC0000_RS13230	COG3764	Sortase (surface protein transpeptidase)
HMPRNC0000_RS13250	COG1760	l-serine dehydratase
HMPRNC0000_RS13255	COG1760	l-serine dehydratase
HMPRNC0000_RS13270	COG0697	spore germination
HMPRNC0000_RS13275	COG0657	acetylesterase activity
HMPRNC0000_RS13295	COG0028	Belongs to the TPP enzyme family
HMPRNC0000_RS13310	COG0583	DNA-binding transcription factor activity
HMPRNC0000_RS13320	COG3942	CHAP domain
HMPRNC0000_RS13330	COG3425	synthase
HMPRNC0000_RS13335	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HMPRNC0000_RS13360	COG2409	Drug exporters of the RND superfamily
HMPRNC0000_RS13405	COG0436	Aminotransferase
HMPRNC0000_RS13435	COG3942	CHAP domain
HMPRNC0000_RS13440	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HMPRNC0000_RS13440	COG2755	lipolytic protein G-D-S-L family
HMPRNC0000_RS13510	COG0596	Alpha beta hydrolase
HMPRNC0000_RS13550	COG3001	Fructosamine kinase
HMPRNC0000_RS13555	COG0167	dihydroorotate dehydrogenase activity
HMPRNC0000_RS13605	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HMPRNC0000_RS13610	COG3527	Alpha-acetolactate decarboxylase
HMPRNC0000_RS13620	COG0531	amino acid
HMPRNC0000_RS13650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HMPRNC0000_RS13670	COG1012	belongs to the aldehyde dehydrogenase family
HMPRNC0000_RS13680	COG1510	regulation of RNA biosynthetic process
HMPRNC0000_RS13690	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HMPRNC0000_RS13715	COG2851	Citrate transporter
HMPRNC0000_RS13730	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HMPRNC0000_RS13740	COG0386	Belongs to the glutathione peroxidase family
HMPRNC0000_RS13765	COG1136	(ABC) transporter
HMPRNC0000_RS13770	COG2205	protein histidine kinase activity
HMPRNC0000_RS13775	COG0745	RESPONSE REGULATOR receiver
HMPRNC0000_RS13795	COG1846	Transcriptional regulator
HMPRNC0000_RS13840	COG1438	arginine binding
HMPRNC0000_RS13860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HMPRNC0000_RS13860	COG3711	transcriptional antiterminator
HMPRNC0000_RS13870	COG1482	cell wall glycoprotein biosynthetic process
HMPRNC0000_RS13880	COG3942	CHAP domain
HMPRNC0000_RS13880	COG1705	Flagellar rod assembly protein muramidase FlgJ
HMPRNC0000_RS13885	COG3433	isochorismatase activity
HMPRNC0000_RS13885	COG1535	isochorismatase
HMPRNC0000_RS13900	COG0438	transferase activity, transferring glycosyl groups
HMPRNC0000_RS13935	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HMPRNC0000_RS13955	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HMPRNC0000_RS14050	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HMPRNC0000_RS14125	COG0471	metal ion transport
HMPRNC0000_RS14130	COG2962	Rard protein
HMPRNC0000_RS14155	COG1136	(ABC) transporter
HMPRNC0000_RS14160	COG0577	efflux transmembrane transporter activity
HMPRNC0000_RS14195	COG1278	Cold shock
HMPRNC0000_RS14220	COG1475	DNA binding