locus-tag	class	description
RM27_RS00015	COG2501	S4 domain
RM27_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
RM27_RS00060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RM27_RS00070	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
RM27_RS00080	COG0305	Participates in initiation and elongation during chromosome replication
RM27_RS00110	COG4863	YycH protein
RM27_RS00120	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
RM27_RS00125	COG0737	Belongs to the 5'-nucleotidase family
RM27_RS00150	COG0584	glycerophosphoryl diester phosphodiesterase
RM27_RS00155	COG2030	dehydratase
RM27_RS00225	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RM27_RS00230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RM27_RS00265	COG2801	Transposase and inactivated derivatives
RM27_RS00270	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RM27_RS00300	COG2801	Transposase and inactivated derivatives
RM27_RS00310	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
RM27_RS00315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RM27_RS00325	COG2235	arginine
RM27_RS00370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RM27_RS00375	COG4172	Belongs to the ABC transporter superfamily
RM27_RS00380	COG1124	(ABC) transporter
RM27_RS00390	COG1388	LysM domain
RM27_RS00405	COG0730	response to heat
RM27_RS00410	COG1937	Protein conserved in bacteria
RM27_RS00415	COG2210	Belongs to the sulfur carrier protein TusA family
RM27_RS00420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RM27_RS00450	COG0655	NAD(P)H dehydrogenase (quinone) activity
RM27_RS00465	COG0583	DNA-binding transcription factor activity
RM27_RS00485	COG0823	Involved in the tonB-independent uptake of proteins
RM27_RS00515	COG1473	amidohydrolase
RM27_RS00525	COG1283	sodium-dependent phosphate transmembrane transporter activity
RM27_RS00530	COG4716	Myosin-crossreactive antigen
RM27_RS00535	COG0697	spore germination
RM27_RS00550	COG1620	l-lactate permease
RM27_RS00565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RM27_RS00570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RM27_RS00575	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RM27_RS00585	COG2423	ornithine cyclodeaminase activity
RM27_RS00590	COG4264	IucA IucC family
RM27_RS00595	COG2814	Major facilitator Superfamily
RM27_RS00600	COG4264	IucA IucC family
RM27_RS00605	COG4264	IucA IucC family
RM27_RS00615	COG0019	diaminopimelate decarboxylase activity
RM27_RS00620	COG1475	DNA binding
RM27_RS00640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RM27_RS00645	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RM27_RS00650	COG0438	transferase activity, transferring glycosyl groups
RM27_RS00680	COG0813	purine-nucleoside phosphorylase activity
RM27_RS00685	COG2814	Major facilitator Superfamily
RM27_RS00705	COG3639	organic phosphonate transmembrane transporter activity
RM27_RS00725	COG0737	Belongs to the 5'-nucleotidase family
RM27_RS00755	COG1454	alcohol dehydrogenase
RM27_RS00755	COG1012	belongs to the aldehyde dehydrogenase family
RM27_RS00780	COG1086	Polysaccharide biosynthesis protein
RM27_RS00790	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
RM27_RS00820	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RM27_RS00830	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
RM27_RS00835	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
RM27_RS00845	COG2832	Protein of unknown function (DUF454)
RM27_RS00880	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RM27_RS00885	COG1960	acyl-CoA dehydrogenase activity
RM27_RS00890	COG5609	conserved protein (DUF2294)
RM27_RS00940	COG1114	Component of the transport system for branched-chain amino acids
RM27_RS00945	COG1335	isochorismatase
RM27_RS00950	COG3961	Belongs to the TPP enzyme family
RM27_RS00975	COG1737	Transcriptional regulator
RM27_RS01005	COG0601	transmembrane transport
RM27_RS01010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RM27_RS01020	COG0405	Gamma-glutamyltransferase
RM27_RS01040	COG3842	ATPase activity
RM27_RS01050	COG1175	transmembrane transport
RM27_RS01055	COG3833	ABC-type maltose transport systems, permease component
RM27_RS01060	COG0673	inositol 2-dehydrogenase activity
RM27_RS01065	COG0673	inositol 2-dehydrogenase activity
RM27_RS01075	COG1755	Isoprenylcysteine carboxyl methyltransferase
RM27_RS01130	COG0183	Belongs to the thiolase family
RM27_RS01140	COG1960	acyl-CoA dehydrogenase activity
RM27_RS01145	COG0318	PFAM AMP-dependent synthetase and ligase
RM27_RS01160	COG0747	negative chemotaxis
RM27_RS01165	COG3189	MarR family transcriptional regulator
RM27_RS01185	COG2190	(PTS) system
RM27_RS01185	COG1263	PTS System
RM27_RS01185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RM27_RS01190	COG1957	nucleoside hydrolase
RM27_RS01205	COG3414	Phosphotransferase system galactitol-specific IIB component
RM27_RS01210	COG3775	system Galactitol-specific IIC component
RM27_RS01215	COG1063	alcohol dehydrogenase
RM27_RS01220	COG1063	alcohol dehydrogenase
RM27_RS01230	COG1063	alcohol dehydrogenase
RM27_RS01235	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
RM27_RS01240	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
RM27_RS01250	COG1063	alcohol dehydrogenase
RM27_RS01255	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
RM27_RS01290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RM27_RS01295	COG1263	PTS System
RM27_RS01295	COG2190	(PTS) system
RM27_RS01295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RM27_RS01300	COG2723	6-phospho-beta-galactosidase activity
RM27_RS01310	COG2226	methyltransferase
RM27_RS01365	COG1131	(ABC) transporter
RM27_RS01395	COG1388	LysM domain
RM27_RS01395	COG3942	CHAP domain
RM27_RS01540	COG1114	Component of the transport system for branched-chain amino acids
RM27_RS01545	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
RM27_RS01550	COG0577	efflux transmembrane transporter activity
RM27_RS01575	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
RM27_RS01580	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RM27_RS01605	COG3314	Sporulation integral membrane protein YlbJ
RM27_RS01625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RM27_RS01655	COG3037	sugar-specific permease SgaT UlaA
RM27_RS01665	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RM27_RS01670	COG3711	transcriptional antiterminator
RM27_RS01690	COG2271	Major facilitator Superfamily
RM27_RS01695	COG0346	lactoylglutathione lyase activity
RM27_RS01700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RM27_RS01705	COG0431	NADPH-dependent FMN reductase
RM27_RS01720	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RM27_RS01735	COG0672	)-iron permease
RM27_RS01740	COG0805	protein transport
RM27_RS01745	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RM27_RS01755	COG1476	TRANSCRIPTIONal
RM27_RS01765	COG1131	(ABC) transporter
RM27_RS01795	COG0646	methionine synthase
RM27_RS01795	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
RM27_RS01800	COG0626	cystathionine gamma-synthase activity
RM27_RS01805	COG0626	cystathionine gamma-synthase activity
RM27_RS01810	COG1475	DNA binding
RM27_RS01815	COG0668	transmembrane transport
RM27_RS01820	COG4481	Protein conserved in bacteria
RM27_RS01825	COG0012	GTP binding
RM27_RS01855	COG4974	Belongs to the 'phage' integrase family
RM27_RS01915	COG3634	alkyl hydroperoxide reductase activity
RM27_RS01930	COG1823	symporter activity
RM27_RS01955	COG2233	PERMEase
RM27_RS01985	COG3759	membrane
RM27_RS02140	COG0523	cobalamin synthesis protein
RM27_RS02145	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RM27_RS02155	COG5609	conserved protein (DUF2294)
RM27_RS02165	COG1647	Serine aminopeptidase, S33
RM27_RS02170	COG0733	neurotransmitter:sodium symporter activity
RM27_RS02175	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RM27_RS02180	COG0626	cystathionine gamma-synthase activity
RM27_RS02190	COG2011	ABC-type metal ion transport system permease component
RM27_RS02195	COG1464	Belongs to the NlpA lipoprotein family
RM27_RS02230	COG0583	DNA-binding transcription factor activity
RM27_RS02235	COG0070	glutamate synthase
RM27_RS02235	COG0069	glutamate synthase activity
RM27_RS02235	COG0067	glutamate synthase
RM27_RS02240	COG0493	'glutamate synthase
RM27_RS02250	COG1263	PTS System
RM27_RS02250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RM27_RS02255	COG0366	Alpha amylase catalytic
RM27_RS02260	COG2188	Transcriptional regulator
RM27_RS02270	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RM27_RS02300	COG1982	Orn Lys Arg decarboxylase major
RM27_RS02310	COG3870	Protein conserved in bacteria
RM27_RS02315	COG0470	DNA polymerase III
RM27_RS02320	COG1774	PSP1 C-terminal conserved region
RM27_RS02330	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
RM27_RS02340	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
RM27_RS02350	COG0084	hydrolase, TatD family'
RM27_RS02355	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
RM27_RS02365	COG4466	Protein conserved in bacteria
RM27_RS02375	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RM27_RS02380	COG0251	oxidation-reduction process
RM27_RS02415	COG2244	polysaccharide biosynthetic process
RM27_RS02420	COG3956	TIGRFAM MazG family protein
RM27_RS02425	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
RM27_RS02435	COG1098	S1 RNA binding domain
RM27_RS02450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RM27_RS02475	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
RM27_RS02515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RM27_RS02530	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
RM27_RS02540	COG3880	PFAM UvrB UvrC protein
RM27_RS02555	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
RM27_RS02560	COG4956	integral membrane protein (PIN domain superfamily)
RM27_RS02580	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
RM27_RS02630	COG2813	Specifically methylates the guanine in position
RM27_RS02670	COG1473	amidohydrolase
RM27_RS02700	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
RM27_RS02705	COG1428	Deoxynucleoside kinase
RM27_RS02710	COG1428	Deoxynucleoside kinase
RM27_RS02720	COG0561	phosphatase activity
RM27_RS02760	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
RM27_RS02865	COG0095	Lipoate-protein ligase
RM27_RS02870	COG0083	homoserine kinase activity
RM27_RS02890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RM27_RS02965	COG0667	Aldo Keto reductase
RM27_RS02970	COG0655	NAD(P)H dehydrogenase (quinone) activity
RM27_RS02980	COG1078	dGTPase activity
RM27_RS03010	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RM27_RS03015	COG4139	cobalamin transport
RM27_RS03065	COG4974	Belongs to the 'phage' integrase family
RM27_RS03110	COG0803	Belongs to the bacterial solute-binding protein 9 family
RM27_RS03115	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RM27_RS03120	COG1121	(ABC) transporter
RM27_RS03125	COG1321	iron dependent repressor
RM27_RS03135	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
RM27_RS03145	COG1682	transport, permease protein
RM27_RS03150	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
RM27_RS03155	COG1216	Glycosyl transferase, family 2
RM27_RS03160	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
RM27_RS03165	COG1686	Belongs to the peptidase S11 family
RM27_RS03170	COG1132	(ABC) transporter
RM27_RS03175	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
RM27_RS03180	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
RM27_RS03185	COG1120	ATPase activity
RM27_RS03190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RM27_RS03195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RM27_RS03200	COG2376	Dihydroxyacetone kinase
RM27_RS03210	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
RM27_RS03220	COG3949	Membrane
RM27_RS03240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RM27_RS03255	COG1136	(ABC) transporter
RM27_RS03260	COG0577	efflux transmembrane transporter activity
RM27_RS03265	COG1392	Phosphate transport regulator
RM27_RS03270	COG0306	phosphate transporter
RM27_RS03275	COG3942	CHAP domain
RM27_RS03275	COG1388	LysM domain
RM27_RS03285	COG1917	Cupin 2, conserved barrel domain protein
RM27_RS03285	COG4977	sequence-specific DNA binding
RM27_RS03310	COG0583	DNA-binding transcription factor activity
RM27_RS03315	COG2814	Major facilitator Superfamily
RM27_RS03320	COG2839	Protein conserved in bacteria
RM27_RS03350	COG1611	Belongs to the LOG family
RM27_RS03370	COG4988	ABC transporter
RM27_RS03375	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
RM27_RS03385	COG0523	cobalamin synthesis protein
RM27_RS03390	COG4989	oxidoreductase activity
RM27_RS03400	COG0471	metal ion transport
RM27_RS03405	COG0415	Belongs to the DNA photolyase family
RM27_RS03435	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RM27_RS03440	COG1349	DNA-binding transcription factor activity
RM27_RS03445	COG1105	Belongs to the carbohydrate kinase PfkB family
RM27_RS03450	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RM27_RS03450	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RM27_RS03450	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RM27_RS03455	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
RM27_RS03460	COG1253	flavin adenine dinucleotide binding
RM27_RS03465	COG0656	L-ascorbic acid biosynthetic process
RM27_RS03470	COG0463	Glycosyl transferase, family 2
RM27_RS03505	COG0720	synthase
RM27_RS03515	COG0512	Glutamine amidotransferase of anthranilate synthase
RM27_RS03515	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RM27_RS03520	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RM27_RS03545	COG0488	(ABC) transporter
RM27_RS03550	COG0514	ATP-dependent DNA helicase (RecQ)
RM27_RS03555	COG0517	IMP dehydrogenase activity
RM27_RS03555	COG1125	glycine betaine transport
RM27_RS03560	COG1174	glycine betaine transport
RM27_RS03580	COG3104	oligopeptide transport
RM27_RS03600	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RM27_RS03605	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RM27_RS03610	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RM27_RS03615	COG4605	iron ion homeostasis
RM27_RS03620	COG4604	ABC transporter, ATP-binding protein
RM27_RS03625	COG4607	ABC-type enterochelin transport system periplasmic component
RM27_RS03680	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RM27_RS03685	COG1739	Uncharacterized protein family UPF0029
RM27_RS03695	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
RM27_RS03700	COG1040	competence protein
RM27_RS03720	COG3942	CHAP domain
RM27_RS03720	COG1388	LysM domain
RM27_RS03780	COG0391	Required for morphogenesis under gluconeogenic growth conditions
RM27_RS03845	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RM27_RS03850	COG1647	Serine aminopeptidase, S33
RM27_RS03855	COG0557	exoribonuclease II activity
RM27_RS03910	COG1278	Cold shock
RM27_RS03950	COG0406	alpha-ribazole phosphatase activity
RM27_RS03955	COG1279	arginine transmembrane transporter activity
RM27_RS03980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RM27_RS03985	COG1393	Belongs to the ArsC family
RM27_RS03995	COG3878	Protein conserved in bacteria
RM27_RS04000	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
RM27_RS04015	COG2011	ABC-type metal ion transport system permease component
RM27_RS04020	COG1464	Belongs to the NlpA lipoprotein family
RM27_RS04025	COG0582	viral genome integration into host DNA
RM27_RS04120	COG0396	ATPase activity
RM27_RS04125	COG0719	Fe-S assembly protein
RM27_RS04135	COG0822	iron-sulfur transferase activity
RM27_RS04150	COG1253	flavin adenine dinucleotide binding
RM27_RS04160	COG1801	Protein of unknown function DUF72
RM27_RS04165	COG0730	response to heat
RM27_RS04180	COG4470	Protein conserved in bacteria
RM27_RS04190	COG2445	Protein of unknown function DUF86
RM27_RS04215	COG1696	Membrane protein involved in D-alanine export
RM27_RS04225	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
RM27_RS04230	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
RM27_RS04235	COG4837	Protein of unknown function (DUF1462)
RM27_RS04240	COG1252	NADH dehydrogenase
RM27_RS04250	COG0316	Belongs to the HesB IscA family
RM27_RS04260	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RM27_RS04265	COG2056	Na+-H+ antiporter family
RM27_RS04270	COG2050	protein possibly involved in aromatic compounds catabolism
RM27_RS04325	COG1098	S1 RNA binding domain
RM27_RS04330	COG1902	pentaerythritol trinitrate reductase activity
RM27_RS04350	COG0584	glycerophosphoryl diester phosphodiesterase
RM27_RS04370	COG0398	Pfam SNARE associated Golgi protein
RM27_RS04410	COG0561	phosphatase activity
RM27_RS04435	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RM27_RS04450	COG1881	PFAM PEBP family protein
RM27_RS04480	COG0601	transmembrane transport
RM27_RS04485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RM27_RS04490	COG0444	Belongs to the ABC transporter superfamily
RM27_RS04495	COG4608	Belongs to the ABC transporter superfamily
RM27_RS04500	COG4166	transmembrane transport
RM27_RS04505	COG0747	negative chemotaxis
RM27_RS04510	COG0444	Belongs to the ABC transporter superfamily
RM27_RS04515	COG4608	Belongs to the ABC transporter superfamily
RM27_RS04520	COG0601	transmembrane transport
RM27_RS04525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RM27_RS04555	COG1164	Oligoendopeptidase f
RM27_RS04565	COG2346	COG2346, Truncated hemoglobins
RM27_RS04580	COG2357	RelA SpoT domain protein
RM27_RS04590	COG0564	pseudouridine synthase activity
RM27_RS04595	COG2239	Acts as a magnesium transporter
RM27_RS04600	COG0569	domain protein
RM27_RS04600	COG0475	glutathione-regulated potassium exporter activity
RM27_RS04610	COG0628	permease
RM27_RS04615	COG1115	amino acid carrier protein
RM27_RS04655	COG0861	Integral membrane protein TerC family
RM27_RS04665	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RM27_RS04670	COG0737	Belongs to the 5'-nucleotidase family
RM27_RS04685	COG4903	ComK protein
RM27_RS04740	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
RM27_RS04745	COG2314	TM2 domain
RM27_RS04750	COG0456	acetyltransferase
RM27_RS04755	COG1575	Belongs to the MenA family. Type 1 subfamily
RM27_RS04760	COG1169	isochorismate synthase
RM27_RS04770	COG2267	carboxylic ester hydrolase activity
RM27_RS04795	COG0436	Aminotransferase
RM27_RS04800	COG3594	Acyltransferase
RM27_RS04825	COG1316	TRANSCRIPTIONal
RM27_RS04830	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
RM27_RS04865	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
RM27_RS04880	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RM27_RS04920	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
RM27_RS04925	COG4172	Belongs to the ABC transporter superfamily
RM27_RS04930	COG4721	ABC-type cobalt transport system, permease component
RM27_RS04940	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
RM27_RS04965	COG1271	oxidase subunit
RM27_RS04970	COG1294	oxidase, subunit
RM27_RS04975	COG0569	domain protein
RM27_RS05035	COG1176	ABC-type spermidine putrescine transport system, permease component I
RM27_RS05040	COG1177	transmembrane transport
RM27_RS05045	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
RM27_RS05070	COG0483	inositol monophosphate 1-phosphatase activity
RM27_RS05080	COG1217	gtp-binding protein TYPA
RM27_RS05085	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RM27_RS05095	COG0772	Belongs to the SEDS family
RM27_RS05125	COG3679	Belongs to the UPF0342 family
RM27_RS05145	COG0742	ribosomal rna small subunit methyltransferase
RM27_RS05200	COG4509	Sortase family
RM27_RS05210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RM27_RS05240	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
RM27_RS05240	COG1796	DNA polymerase
RM27_RS05260	COG2009	succinate dehydrogenase
RM27_RS05265	COG1053	succinate dehydrogenase
RM27_RS05270	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RM27_RS05370	COG1288	antiporter activity
RM27_RS05405	COG1011	Hydrolase
RM27_RS05430	COG4839	cell division protein FtsL
RM27_RS05435	COG0768	penicillin binding
RM27_RS05450	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
RM27_RS05455	COG0849	cell division
RM27_RS05470	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
RM27_RS05480	COG0762	integral membrane protein
RM27_RS05485	COG2302	S4 RNA-binding domain
RM27_RS05490	COG3599	regulation of cell shape
RM27_RS05500	COG2514	catechol 2,3-dioxygenase activity
RM27_RS05515	COG0564	pseudouridine synthase activity
RM27_RS05525	COG2233	PERMEase
RM27_RS05570	COG1293	RNA-binding protein homologous to eukaryotic snRNP
RM27_RS05585	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
RM27_RS05590	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
RM27_RS05600	COG2314	TM2 domain
RM27_RS05615	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RM27_RS05615	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RM27_RS05625	COG0631	protein serine/threonine phosphatase activity
RM27_RS05640	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RM27_RS05655	COG1302	Protein conserved in bacteria
RM27_RS05665	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RM27_RS05700	COG1196	nuclear chromosome segregation
RM27_RS05705	COG0552	protein localization to endoplasmic reticulum
RM27_RS05715	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
RM27_RS05775	COG0758	DNA mediated transformation
RM27_RS05860	COG0195	Participates in both transcription termination and antitermination
RM27_RS05865	COG2740	Nucleic-acid-binding protein implicated in transcription termination
RM27_RS05890	COG0196	riboflavin kinase activity
RM27_RS05915	COG2188	Transcriptional regulator
RM27_RS05920	COG0612	Peptidase, M16
RM27_RS05925	COG0612	Peptidase, M16
RM27_RS05930	COG0300	oxidoreductase activity
RM27_RS05950	COG1546	Belongs to the CinA family
RM27_RS05950	COG1058	Belongs to the CinA family
RM27_RS05970	COG1692	metallophosphoesterase
RM27_RS05975	COG0674	pyruvate-flavodoxin oxidoreductase activity
RM27_RS05975	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
RM27_RS05980	COG1013	pyruvate-flavodoxin oxidoreductase activity
RM27_RS06015	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
RM27_RS06020	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RM27_RS06045	COG1923	regulation of RNA biosynthetic process
RM27_RS06055	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RM27_RS06060	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
RM27_RS06065	COG0789	Transcriptional regulator
RM27_RS06140	COG1131	(ABC) transporter
RM27_RS06155	COG2197	response regulator
RM27_RS06165	COG1525	nuclease
RM27_RS06180	COG0527	aspartate kinase activity
RM27_RS06185	COG0460	homoserine dehydrogenase
RM27_RS06190	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
RM27_RS06210	COG0833	amino acid
RM27_RS06235	COG2340	Cysteine-rich secretory protein family
RM27_RS06265	COG4846	Membrane protein involved in cytochrome C biogenesis
RM27_RS06285	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RM27_RS06295	COG0824	Thioesterase
RM27_RS06320	COG1115	amino acid carrier protein
RM27_RS06330	COG0628	permease
RM27_RS06335	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
RM27_RS06335	COG0392	lysyltransferase activity
RM27_RS06355	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RM27_RS06365	COG1363	Peptidase, m42
RM27_RS06370	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RM27_RS06375	COG0512	Glutamine amidotransferase of anthranilate synthase
RM27_RS06415	COG0561	phosphatase activity
RM27_RS06455	COG0704	Plays a role in the regulation of phosphate uptake
RM27_RS06465	COG0581	inorganic phosphate transmembrane transporter activity
RM27_RS06470	COG0573	inorganic phosphate transmembrane transporter activity
RM27_RS06490	COG0488	(ABC) transporter
RM27_RS06495	COG0527	aspartate kinase activity
RM27_RS06500	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RM27_RS06580	COG4548	von Willebrand factor, type A
RM27_RS06630	COG0671	phosphoesterase, PA-phosphatase related
RM27_RS06700	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
RM27_RS06720	COG0531	amino acid
RM27_RS06735	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RM27_RS06740	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
RM27_RS06755	COG0116	Belongs to the methyltransferase superfamily
RM27_RS06780	COG4499	WXG100 protein secretion system (Wss), protein YukC
RM27_RS06780	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RM27_RS06790	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
RM27_RS06795	COG3935	DnaD domain protein
RM27_RS06820	COG0438	transferase activity, transferring glycosyl groups
RM27_RS06825	COG1694	Mazg nucleotide pyrophosphohydrolase
RM27_RS06830	COG2738	Putative neutral zinc metallopeptidase
RM27_RS06835	COG4347	Protein of unknown function (DUF1405)
RM27_RS06875	COG0142	geranyltranstransferase activity
RM27_RS06920	COG0492	ferredoxin-NADP+ reductase activity
RM27_RS06930	COG0514	ATP-dependent DNA helicase (RecQ)
RM27_RS06940	COG1141	Ferredoxin
RM27_RS06985	COG1388	LysM domain
RM27_RS06985	COG0860	N-Acetylmuramoyl-L-alanine amidase
RM27_RS07035	COG5280	Phage tail tape measure protein TP901
RM27_RS07035	COG3953	SLT domain
RM27_RS07275	COG0582	viral genome integration into host DNA
RM27_RS07290	COG5002	protein histidine kinase activity
RM27_RS07295	COG0745	RESPONSE REGULATOR receiver
RM27_RS07300	COG1187	pseudouridine synthase activity
RM27_RS07325	COG0735	belongs to the Fur family
RM27_RS07330	COG0494	nUDIX hydrolase
RM27_RS07335	COG0667	Aldo Keto reductase
RM27_RS07345	COG4221	oxidoreductase activity
RM27_RS07360	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
RM27_RS07370	COG0366	Alpha amylase catalytic
RM27_RS07375	COG1609	Transcriptional regulator
RM27_RS07390	COG2195	Cleaves the N-terminal amino acid of tripeptides
RM27_RS07400	COG4129	membrane
RM27_RS07410	COG0508	dehydrogenase complex catalyzes the overall conversion of
RM27_RS07415	COG0022	dehydrogenase e1 component
RM27_RS07420	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
RM27_RS07425	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RM27_RS07430	COG0497	DNA recombination
RM27_RS07460	COG1302	Protein conserved in bacteria
RM27_RS07465	COG0439	Biotin carboxylase
RM27_RS07470	COG0511	ligase activity, forming carbon-carbon bonds
RM27_RS07475	COG2826	transposase and inactivated derivatives, IS30 family
RM27_RS07505	COG1674	ftsk spoiiie
RM27_RS07510	COG0433	COG0433 Predicted ATPase
RM27_RS07530	COG2946	Replication initiation factor
RM27_RS07555	COG0006	proline dipeptidase activity
RM27_RS07570	COG0095	Lipoate-protein ligase
RM27_RS07575	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RM27_RS07615	COG4537	Required for transformation and DNA binding
RM27_RS07620	COG1459	type II secretion system
RM27_RS07625	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RM27_RS07630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RM27_RS07635	COG0011	TIGRFAM Protein of
RM27_RS07640	COG1940	carbohydrate kinase activity
RM27_RS07645	COG4483	Protein conserved in bacteria
RM27_RS07655	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
RM27_RS07665	COG0768	penicillin binding
RM27_RS07680	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RM27_RS07685	COG1121	(ABC) transporter
RM27_RS07695	COG0513	Belongs to the DEAD box helicase family
RM27_RS07705	COG2384	SAM-dependent methyltransferase
RM27_RS07725	COG0517	IMP dehydrogenase activity
RM27_RS07745	COG0295	cytidine deaminase activity
RM27_RS07760	COG1702	phosphate starvation-inducible protein PhoH
RM27_RS07775	COG1030	water channel activity
RM27_RS07785	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RM27_RS07790	COG1385	rRNA (uridine-N3-)-methyltransferase activity
RM27_RS07820	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RM27_RS07835	COG1466	dna polymerase III delta subunit
RM27_RS07840	COG2333	competence protein COMEC
RM27_RS07840	COG0658	competence protein
RM27_RS07845	COG2131	deaminase
RM27_RS07855	COG2226	methyltransferase
RM27_RS07860	COG0799	negative regulation of ribosome biogenesis
RM27_RS07865	COG1713	HD superfamily hydrolase involved in NAD metabolism
RM27_RS07875	COG1534	Rna-binding protein
RM27_RS07885	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
RM27_RS07890	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
RM27_RS07910	COG3177	Filamentation induced by cAMP protein fic
RM27_RS07915	COG1914	H( )-stimulated, divalent metal cation uptake system
RM27_RS07925	COG0439	Biotin carboxylase
RM27_RS07930	COG0511	ligase activity, forming carbon-carbon bonds
RM27_RS07935	COG1984	allophanate hydrolase subunit 2
RM27_RS07940	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
RM27_RS07955	COG0826	peptidase U32
RM27_RS07960	COG0826	peptidase U32
RM27_RS07990	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RM27_RS08005	COG1104	cysteine desulfurase activity
RM27_RS08010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RM27_RS08020	COG1959	2 iron, 2 sulfur cluster binding
RM27_RS08025	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
RM27_RS08030	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
RM27_RS08065	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
RM27_RS08065	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
RM27_RS08070	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RM27_RS08070	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RM27_RS08075	COG1862	Preprotein translocase
RM27_RS08115	COG2868	ribosomal protein
RM27_RS08150	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
RM27_RS08155	COG0285	dihydrofolate synthase activity
RM27_RS08165	COG2818	Glycosylase
RM27_RS08195	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RM27_RS08225	COG4112	unkown
RM27_RS08245	COG0833	amino acid
RM27_RS08255	COG1484	DNA-dependent DNA replication
RM27_RS08285	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RM27_RS08285	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RM27_RS08295	COG5002	protein histidine kinase activity
RM27_RS08300	COG0745	RESPONSE REGULATOR receiver
RM27_RS08310	COG0372	Belongs to the citrate synthase family
RM27_RS08315	COG1113	amino acid transport
RM27_RS08350	COG0281	malic enzyme
RM27_RS08360	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
RM27_RS08365	COG4109	DRTGG domain
RM27_RS08400	COG0827	DNA restriction-modification system
RM27_RS08420	COG1104	cysteine desulfurase activity
RM27_RS08430	COG1956	GAF domain-containing protein
RM27_RS08440	COG0584	glycerophosphoryl diester phosphodiesterase
RM27_RS08445	COG1764	response to oxidative stress
RM27_RS08450	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
RM27_RS08455	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RM27_RS08465	COG1263	PTS System
RM27_RS08465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RM27_RS08470	COG0204	Acyl-transferase
RM27_RS08475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RM27_RS08500	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RM27_RS08505	COG0454	-acetyltransferase
RM27_RS08520	COG1605	Chorismate mutase
RM27_RS08520	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
RM27_RS08540	COG1674	ftsk spoiiie
RM27_RS08545	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RM27_RS08555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RM27_RS08560	COG1363	Peptidase, m42
RM27_RS08570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RM27_RS08580	COG0510	thiamine kinase activity
RM27_RS08600	COG1187	pseudouridine synthase activity
RM27_RS08605	COG2244	polysaccharide biosynthetic process
RM27_RS08610	COG2081	HI0933 family
RM27_RS08630	COG2814	Major facilitator Superfamily
RM27_RS08635	COG1242	4 iron, 4 sulfur cluster binding
RM27_RS08640	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
RM27_RS08660	COG2267	carboxylic ester hydrolase activity
RM27_RS08685	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RM27_RS08685	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RM27_RS08710	COG5632	N-Acetylmuramoyl-L-alanine amidase
RM27_RS08710	COG4193	domain, Protein
RM27_RS08710	COG3266	domain, Protein
RM27_RS08740	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RM27_RS08770	COG0656	L-ascorbic acid biosynthetic process
RM27_RS08795	COG1506	peptidase
RM27_RS08940	COG1131	(ABC) transporter
RM27_RS09040	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
RM27_RS09065	COG1131	(ABC) transporter
RM27_RS09070	COG0537	adenosine 5'-monophosphoramidase activity
RM27_RS09100	COG0420	3'-5' exonuclease activity
RM27_RS09120	COG2197	response regulator
RM27_RS09125	COG4585	Histidine kinase
RM27_RS09125	COG2203	Gaf domain
RM27_RS09130	COG0564	pseudouridine synthase activity
RM27_RS09160	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
RM27_RS09165	COG1126	abc transporter atp-binding protein
RM27_RS09170	COG0765	amino acid transport
RM27_RS09340	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RM27_RS09345	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RM27_RS09355	COG4129	membrane
RM27_RS09375	COG1988	membrane-bound metal-dependent
RM27_RS09385	COG1134	teichoic acid transport
RM27_RS09385	COG1388	LysM domain
RM27_RS09410	COG0535	radical SAM domain protein
RM27_RS09415	COG1607	acyl-coa hydrolase
RM27_RS09420	COG2309	aminopeptidase activity
RM27_RS09440	COG1295	ribonuclease BN
RM27_RS09445	COG2197	response regulator
RM27_RS09545	COG4851	CamS sex pheromone cAM373 precursor
RM27_RS09555	COG0210	DNA helicase
RM27_RS09565	COG4496	protein, YerC YecD
RM27_RS09595	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
RM27_RS09605	COG0077	Prephenate dehydratase
RM27_RS09620	COG1335	isochorismatase
RM27_RS09630	COG1012	belongs to the aldehyde dehydrogenase family
RM27_RS09675	COG1131	(ABC) transporter
RM27_RS09690	COG1725	Transcriptional regulator
RM27_RS09730	COG0860	N-Acetylmuramoyl-L-alanine amidase
RM27_RS09730	COG1388	LysM domain
RM27_RS09740	COG1388	LysM domain
RM27_RS09740	COG5632	N-Acetylmuramoyl-L-alanine amidase
RM27_RS09780	COG0739	heme binding
RM27_RS09830	COG0740	serine-type endopeptidase activity
RM27_RS10000	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RM27_RS10050	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
RM27_RS10055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RM27_RS10060	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RM27_RS10075	COG5484	DNA packaging
RM27_RS10075	COG3728	DNA packaging
RM27_RS10140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RM27_RS10145	COG1621	beta-fructofuranosidase activity
RM27_RS10150	COG1609	Transcriptional regulator
RM27_RS10155	COG0004	ammonium transporteR
RM27_RS10160	COG0425	Belongs to the sulfur carrier protein TusA family
RM27_RS10165	COG2391	methyltransferase activity
RM27_RS10175	COG0488	(ABC) transporter
RM27_RS10180	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
RM27_RS10190	COG0456	acetyltransferase
RM27_RS10195	COG1214	PFAM Peptidase M22, glycoprotease
RM27_RS10200	COG0802	atpase or kinase
RM27_RS10210	COG0028	Belongs to the TPP enzyme family
RM27_RS10280	COG2183	response to ionizing radiation
RM27_RS10285	COG1191	sigma factor activity
RM27_RS10295	COG1366	Belongs to the anti-sigma-factor antagonist family
RM27_RS10300	COG2208	phosphoserine phosphatase activity
RM27_RS10330	COG3428	Bacterial PH domain
RM27_RS10360	COG2205	protein histidine kinase activity
RM27_RS10365	COG0745	RESPONSE REGULATOR receiver
RM27_RS10375	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
RM27_RS10385	COG0772	Belongs to the SEDS family
RM27_RS10395	COG1937	Protein conserved in bacteria
RM27_RS10405	COG1418	mRNA catabolic process
RM27_RS10440	COG0629	single-stranded DNA binding
RM27_RS10510	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
RM27_RS10535	COG0009	L-threonylcarbamoyladenylate synthase
RM27_RS10540	COG2890	protein-(glutamine-N5) methyltransferase activity
RM27_RS10560	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
RM27_RS10600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RM27_RS10645	COG0813	purine-nucleoside phosphorylase activity
RM27_RS10650	COG0783	Belongs to the Dps family
RM27_RS10670	COG1482	cell wall glycoprotein biosynthetic process
RM27_RS10675	COG0702	epimerase
RM27_RS10680	COG0640	Transcriptional regulator
RM27_RS10705	COG0561	phosphatase activity
RM27_RS10710	COG1119	ATPase activity
RM27_RS10725	COG3711	transcriptional antiterminator
RM27_RS10755	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
RM27_RS10815	COG0489	protein tyrosine kinase activity
RM27_RS10820	COG2814	Major facilitator Superfamily
RM27_RS10835	COG1272	protein, Hemolysin III
RM27_RS10845	COG1988	membrane-bound metal-dependent
RM27_RS10855	COG3314	Sporulation integral membrane protein YlbJ
RM27_RS10860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RM27_RS10865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RM27_RS10870	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
RM27_RS10875	COG3457	Alanine racemase
RM27_RS10880	COG4264	IucA IucC family
RM27_RS10885	COG2814	Major facilitator Superfamily
RM27_RS10925	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RM27_RS10935	COG2130	NADP-dependent
RM27_RS10985	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
RM27_RS10995	COG0656	L-ascorbic acid biosynthetic process
RM27_RS11000	COG0789	Transcriptional regulator
RM27_RS11005	COG5492	domain, Protein
RM27_RS11025	COG3527	Alpha-acetolactate decarboxylase
RM27_RS11030	COG0028	Belongs to the TPP enzyme family
RM27_RS11050	COG0542	response to heat
RM27_RS11135	COG0201	protein transport
RM27_RS11250	COG2252	PERMEase
RM27_RS11280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RM27_RS11330	COG1763	Mo-molybdopterin cofactor biosynthetic process
RM27_RS11350	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RM27_RS11355	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
RM27_RS11360	COG4149	molybdate abc transporter
RM27_RS11365	COG0725	ABC transporter, periplasmic molybdate-binding protein
RM27_RS11380	COG1268	BioY protein
RM27_RS11395	COG1960	acyl-CoA dehydrogenase activity
RM27_RS11400	COG4413	Urea transporter
RM27_RS11460	COG3942	CHAP domain
RM27_RS11465	COG1757	Na H antiporter
RM27_RS11480	COG3942	CHAP domain
RM27_RS11545	COG1113	amino acid transport
RM27_RS11565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RM27_RS11570	COG0385	Bile acid
RM27_RS11580	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RM27_RS11580	COG1263	PTS System
RM27_RS11585	COG1737	Transcriptional regulator
RM27_RS11605	COG1028	Short-chain dehydrogenase reductase Sdr
RM27_RS11610	COG1473	amidohydrolase
RM27_RS11625	COG0583	DNA-binding transcription factor activity
RM27_RS11650	COG2258	MOSC domain
RM27_RS11665	COG1668	transmembrane transport
RM27_RS11670	COG4152	abc transporter atp-binding protein
RM27_RS11675	COG3152	Membrane
RM27_RS11685	COG0786	glutamate:sodium symporter activity
RM27_RS11695	COG0598	Magnesium transport protein CorA
RM27_RS11710	COG0657	acetylesterase activity
RM27_RS11720	COG2814	Major facilitator Superfamily
RM27_RS11725	COG1566	PFAM secretion protein HlyD family protein
RM27_RS11735	COG2814	Major facilitator Superfamily
RM27_RS11795	COG1620	l-lactate permease
RM27_RS11815	COG0604	alcohol dehydrogenase
RM27_RS11820	COG0456	acetyltransferase
RM27_RS11835	COG1511	domain protein
RM27_RS11850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RM27_RS11850	COG1263	PTS System
RM27_RS11865	COG3871	stress protein (general stress protein 26)
RM27_RS11910	COG0789	Transcriptional regulator
RM27_RS11930	COG2181	nitrate reductase activity
RM27_RS11940	COG1140	nitrate reductase beta subunit
RM27_RS11945	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
RM27_RS11955	COG2146	nitrite reductase [NAD(P)H] activity
RM27_RS11960	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RM27_RS11970	COG0454	-acetyltransferase
RM27_RS11975	COG2116	formate transmembrane transporter activity
RM27_RS11990	COG0803	Belongs to the bacterial solute-binding protein 9 family
RM27_RS11990	COG3443	Belongs to the bacterial solute-binding protein 9 family
RM27_RS12020	COG1126	abc transporter atp-binding protein
RM27_RS12025	COG0765	amino acid transport
RM27_RS12030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RM27_RS12035	COG2814	Major facilitator Superfamily
RM27_RS12045	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
RM27_RS12080	COG0156	8-amino-7-oxononanoate synthase activity
RM27_RS12090	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RM27_RS12095	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
RM27_RS12100	COG1132	(ABC) transporter
RM27_RS12105	COG1132	(ABC) transporter
RM27_RS12105	COG2375	cellular response to nickel ion
RM27_RS12115	COG1929	Belongs to the glycerate kinase type-1 family
RM27_RS12125	COG2814	Major facilitator Superfamily
RM27_RS12145	COG1113	amino acid transport
RM27_RS12155	COG0531	amino acid
RM27_RS12170	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
RM27_RS12180	COG1174	glycine betaine transport
RM27_RS12190	COG1174	glycine betaine transport
RM27_RS12200	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
RM27_RS12205	COG0531	amino acid
RM27_RS12210	COG2272	Belongs to the type-B carboxylesterase lipase family
RM27_RS12215	COG2814	Major facilitator Superfamily
RM27_RS12220	COG0390	transport system, permease component
RM27_RS12225	COG4619	ABC transporter
RM27_RS12230	COG1363	Peptidase, m42
RM27_RS12245	COG4808	Protein conserved in bacteria
RM27_RS12250	COG0069	glutamate synthase activity
RM27_RS12265	COG1124	(ABC) transporter
RM27_RS12270	COG0444	Belongs to the ABC transporter superfamily
RM27_RS12275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RM27_RS12280	COG0601	transmembrane transport
RM27_RS12285	COG0747	negative chemotaxis
RM27_RS12315	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
RM27_RS12320	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RM27_RS12395	COG0494	nUDIX hydrolase
RM27_RS12425	COG3583	domain protein
RM27_RS12430	COG1846	Transcriptional regulator
RM27_RS12435	COG1846	Transcriptional regulator
RM27_RS12460	COG1070	Carbohydrate kinase
RM27_RS12465	COG1802	Transcriptional regulator
RM27_RS12470	COG0789	Transcriptional regulator
RM27_RS12475	COG2357	RelA SpoT domain protein
RM27_RS12480	COG4876	unkown
RM27_RS12490	COG2271	Major facilitator Superfamily
RM27_RS12495	COG0586	Pfam SNARE associated Golgi protein
RM27_RS12500	COG2814	Major facilitator Superfamily
RM27_RS12505	COG1846	Transcriptional regulator
RM27_RS12510	COG1131	(ABC) transporter
RM27_RS12525	COG3949	Membrane
RM27_RS12530	COG0400	carboxylic ester hydrolase activity
RM27_RS12535	COG0346	lactoylglutathione lyase activity
RM27_RS12540	COG1846	Transcriptional regulator
RM27_RS12550	COG2514	catechol 2,3-dioxygenase activity
RM27_RS12565	COG0561	phosphatase activity
RM27_RS12570	COG1131	(ABC) transporter
RM27_RS12580	COG3764	Sortase (surface protein transpeptidase)
RM27_RS12590	COG1760	l-serine dehydratase
RM27_RS12595	COG1760	l-serine dehydratase
RM27_RS12610	COG0697	spore germination
RM27_RS12615	COG0657	acetylesterase activity
RM27_RS12635	COG0028	Belongs to the TPP enzyme family
RM27_RS12650	COG0583	DNA-binding transcription factor activity
RM27_RS12660	COG3942	CHAP domain
RM27_RS12675	COG3425	synthase
RM27_RS12680	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RM27_RS12685	COG0542	response to heat
RM27_RS12700	COG2409	Drug exporters of the RND superfamily
RM27_RS12740	COG0436	Aminotransferase
RM27_RS12770	COG3942	CHAP domain
RM27_RS12775	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
RM27_RS12775	COG2755	lipolytic protein G-D-S-L family
RM27_RS12875	COG3001	Fructosamine kinase
RM27_RS12880	COG0167	dihydroorotate dehydrogenase activity
RM27_RS12925	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
RM27_RS12930	COG3527	Alpha-acetolactate decarboxylase
RM27_RS12940	COG0531	amino acid
RM27_RS12960	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RM27_RS12980	COG1012	belongs to the aldehyde dehydrogenase family
RM27_RS12985	COG1510	regulation of RNA biosynthetic process
RM27_RS12995	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RM27_RS13010	COG2851	Citrate transporter
RM27_RS13020	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
RM27_RS13025	COG0386	Belongs to the glutathione peroxidase family
RM27_RS13035	COG1136	(ABC) transporter
RM27_RS13040	COG2205	protein histidine kinase activity
RM27_RS13045	COG0745	RESPONSE REGULATOR receiver
RM27_RS13055	COG1785	Belongs to the alkaline phosphatase family
RM27_RS13060	COG1846	Transcriptional regulator
RM27_RS13100	COG1438	arginine binding
RM27_RS13120	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RM27_RS13120	COG3711	transcriptional antiterminator
RM27_RS13125	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RM27_RS13125	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RM27_RS13125	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RM27_RS13130	COG1482	cell wall glycoprotein biosynthetic process
RM27_RS13140	COG1705	Flagellar rod assembly protein muramidase FlgJ
RM27_RS13140	COG3942	CHAP domain
RM27_RS13145	COG1535	isochorismatase
RM27_RS13145	COG3433	isochorismatase activity
RM27_RS13160	COG0438	transferase activity, transferring glycosyl groups
RM27_RS13175	COG1073	alpha beta
RM27_RS13195	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RM27_RS13215	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RM27_RS13270	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
RM27_RS13300	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RM27_RS13385	COG0471	metal ion transport
RM27_RS13390	COG2962	Rard protein
RM27_RS13400	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
RM27_RS13415	COG1136	(ABC) transporter
RM27_RS13420	COG0577	efflux transmembrane transporter activity
RM27_RS13445	COG1278	Cold shock
RM27_RS13465	COG1475	DNA binding