locus-tag	class	description
RK78_RS00010	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
RK78_RS00070	COG0489	protein tyrosine kinase activity
RK78_RS00075	COG2814	Major facilitator Superfamily
RK78_RS00090	COG1272	protein, Hemolysin III
RK78_RS00100	COG1988	membrane-bound metal-dependent
RK78_RS00115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RK78_RS00120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RK78_RS00125	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
RK78_RS00135	COG3457	Alanine racemase
RK78_RS00140	COG4264	IucA IucC family
RK78_RS00145	COG2814	Major facilitator Superfamily
RK78_RS00170	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RK78_RS00180	COG2130	NADP-dependent
RK78_RS00250	COG0656	L-ascorbic acid biosynthetic process
RK78_RS00255	COG0789	Transcriptional regulator
RK78_RS00265	COG5492	domain, Protein
RK78_RS00285	COG3527	Alpha-acetolactate decarboxylase
RK78_RS00290	COG0028	Belongs to the TPP enzyme family
RK78_RS00380	COG0201	protein transport
RK78_RS00495	COG2252	PERMEase
RK78_RS00540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RK78_RS00605	COG1763	Mo-molybdopterin cofactor biosynthetic process
RK78_RS00625	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RK78_RS00630	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
RK78_RS00635	COG4149	molybdate abc transporter
RK78_RS00640	COG0725	ABC transporter, periplasmic molybdate-binding protein
RK78_RS00655	COG1268	BioY protein
RK78_RS00675	COG4413	Urea transporter
RK78_RS00750	COG1757	Na H antiporter
RK78_RS00765	COG3942	CHAP domain
RK78_RS00840	COG1113	amino acid transport
RK78_RS00860	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RK78_RS00865	COG0385	Bile acid
RK78_RS00875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RK78_RS00875	COG1263	PTS System
RK78_RS00880	COG1737	Transcriptional regulator
RK78_RS00905	COG1473	amidohydrolase
RK78_RS00920	COG0583	DNA-binding transcription factor activity
RK78_RS00945	COG2258	MOSC domain
RK78_RS00970	COG4152	abc transporter atp-binding protein
RK78_RS00990	COG0786	glutamate:sodium symporter activity
RK78_RS01000	COG0598	Magnesium transport protein CorA
RK78_RS01015	COG0657	acetylesterase activity
RK78_RS01025	COG2814	Major facilitator Superfamily
RK78_RS01030	COG1566	PFAM secretion protein HlyD family protein
RK78_RS01045	COG2814	Major facilitator Superfamily
RK78_RS01110	COG1131	(ABC) transporter
RK78_RS01125	COG1620	l-lactate permease
RK78_RS01145	COG0604	alcohol dehydrogenase
RK78_RS01175	COG1511	domain protein
RK78_RS01190	COG1263	PTS System
RK78_RS01190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RK78_RS01205	COG3871	stress protein (general stress protein 26)
RK78_RS01250	COG0789	Transcriptional regulator
RK78_RS01270	COG2181	nitrate reductase activity
RK78_RS01280	COG1140	nitrate reductase beta subunit
RK78_RS01285	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
RK78_RS01295	COG2146	nitrite reductase [NAD(P)H] activity
RK78_RS01300	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RK78_RS01310	COG0454	-acetyltransferase
RK78_RS01315	COG2116	formate transmembrane transporter activity
RK78_RS01330	COG0803	Belongs to the bacterial solute-binding protein 9 family
RK78_RS01330	COG3443	Belongs to the bacterial solute-binding protein 9 family
RK78_RS01365	COG1126	abc transporter atp-binding protein
RK78_RS01370	COG0765	amino acid transport
RK78_RS01375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RK78_RS01380	COG2814	Major facilitator Superfamily
RK78_RS01400	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
RK78_RS01450	COG0156	8-amino-7-oxononanoate synthase activity
RK78_RS01460	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RK78_RS01465	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
RK78_RS01480	COG1132	(ABC) transporter
RK78_RS01505	COG1929	Belongs to the glycerate kinase type-1 family
RK78_RS01515	COG2814	Major facilitator Superfamily
RK78_RS01535	COG1113	amino acid transport
RK78_RS01550	COG0531	amino acid
RK78_RS01570	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
RK78_RS01580	COG1174	glycine betaine transport
RK78_RS01610	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
RK78_RS01615	COG0531	amino acid
RK78_RS01620	COG2272	Belongs to the type-B carboxylesterase lipase family
RK78_RS01625	COG2814	Major facilitator Superfamily
RK78_RS01630	COG0390	transport system, permease component
RK78_RS01635	COG4619	ABC transporter
RK78_RS01640	COG1363	Peptidase, m42
RK78_RS01660	COG4808	Protein conserved in bacteria
RK78_RS01665	COG0069	glutamate synthase activity
RK78_RS01680	COG1124	(ABC) transporter
RK78_RS01690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RK78_RS01695	COG0601	transmembrane transport
RK78_RS01700	COG0747	negative chemotaxis
RK78_RS01720	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
RK78_RS01725	COG1028	Short-chain dehydrogenase reductase Sdr
RK78_RS01730	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
RK78_RS01735	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RK78_RS01815	COG2826	transposase and inactivated derivatives, IS30 family
RK78_RS01825	COG0494	nUDIX hydrolase
RK78_RS01875	COG1070	Carbohydrate kinase
RK78_RS01880	COG1802	Transcriptional regulator
RK78_RS01885	COG0789	Transcriptional regulator
RK78_RS01890	COG2357	RelA SpoT domain protein
RK78_RS01895	COG4876	unkown
RK78_RS01905	COG2271	Major facilitator Superfamily
RK78_RS01910	COG0586	Pfam SNARE associated Golgi protein
RK78_RS01915	COG1279	arginine transmembrane transporter activity
RK78_RS01935	COG1131	(ABC) transporter
RK78_RS01955	COG0400	carboxylic ester hydrolase activity
RK78_RS01960	COG0346	lactoylglutathione lyase activity
RK78_RS01965	COG1846	Transcriptional regulator
RK78_RS01975	COG2514	catechol 2,3-dioxygenase activity
RK78_RS01995	COG0561	phosphatase activity
RK78_RS02000	COG3764	Sortase (surface protein transpeptidase)
RK78_RS02020	COG1760	l-serine dehydratase
RK78_RS02025	COG1760	l-serine dehydratase
RK78_RS02040	COG0697	spore germination
RK78_RS02045	COG0657	acetylesterase activity
RK78_RS02065	COG0028	Belongs to the TPP enzyme family
RK78_RS02080	COG0583	DNA-binding transcription factor activity
RK78_RS02090	COG3942	CHAP domain
RK78_RS02100	COG3425	synthase
RK78_RS02105	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RK78_RS02130	COG2409	Drug exporters of the RND superfamily
RK78_RS02175	COG0436	Aminotransferase
RK78_RS02310	COG3001	Fructosamine kinase
RK78_RS02315	COG0167	dihydroorotate dehydrogenase activity
RK78_RS02365	COG3527	Alpha-acetolactate decarboxylase
RK78_RS02380	COG0531	amino acid
RK78_RS02410	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RK78_RS02430	COG1012	belongs to the aldehyde dehydrogenase family
RK78_RS02440	COG1510	regulation of RNA biosynthetic process
RK78_RS02445	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RK78_RS02470	COG2851	Citrate transporter
RK78_RS02485	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
RK78_RS02495	COG0386	Belongs to the glutathione peroxidase family
RK78_RS02520	COG1136	(ABC) transporter
RK78_RS02525	COG2205	protein histidine kinase activity
RK78_RS02530	COG0745	RESPONSE REGULATOR receiver
RK78_RS02540	COG1785	Belongs to the alkaline phosphatase family
RK78_RS02550	COG1846	Transcriptional regulator
RK78_RS02595	COG1438	arginine binding
RK78_RS02615	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RK78_RS02615	COG3711	transcriptional antiterminator
RK78_RS02620	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RK78_RS02620	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RK78_RS02620	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RK78_RS02625	COG1482	cell wall glycoprotein biosynthetic process
RK78_RS02635	COG1705	Flagellar rod assembly protein muramidase FlgJ
RK78_RS02635	COG3942	CHAP domain
RK78_RS02640	COG3433	isochorismatase activity
RK78_RS02640	COG1535	isochorismatase
RK78_RS02655	COG0438	transferase activity, transferring glycosyl groups
RK78_RS02670	COG1073	alpha beta
RK78_RS02690	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RK78_RS02715	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RK78_RS02805	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RK78_RS02885	COG0471	metal ion transport
RK78_RS02890	COG2962	Rard protein
RK78_RS02900	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
RK78_RS02915	COG1136	(ABC) transporter
RK78_RS02920	COG0577	efflux transmembrane transporter activity
RK78_RS02945	COG1404	Belongs to the peptidase S8 family
RK78_RS02950	COG1278	Cold shock
RK78_RS02970	COG1475	DNA binding
RK78_RS03010	COG2501	S4 domain
RK78_RS03030	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
RK78_RS03060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RK78_RS03070	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
RK78_RS03080	COG0305	Participates in initiation and elongation during chromosome replication
RK78_RS03115	COG4863	YycH protein
RK78_RS03125	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
RK78_RS03130	COG0737	Belongs to the 5'-nucleotidase family
RK78_RS03155	COG3425	synthase
RK78_RS03165	COG0584	glycerophosphoryl diester phosphodiesterase
RK78_RS03170	COG2030	dehydratase
RK78_RS03275	COG2826	transposase and inactivated derivatives, IS30 family
RK78_RS03285	COG1401	restriction endodeoxyribonuclease activity
RK78_RS03290	COG4268	DNA restriction-modification system
RK78_RS03315	COG2814	Major facilitator Superfamily
RK78_RS03340	COG0456	acetyltransferase
RK78_RS03375	COG0823	Involved in the tonB-independent uptake of proteins
RK78_RS03390	COG1473	amidohydrolase
RK78_RS03400	COG1283	sodium-dependent phosphate transmembrane transporter activity
RK78_RS03405	COG4716	Myosin-crossreactive antigen
RK78_RS03415	COG1620	l-lactate permease
RK78_RS03435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RK78_RS03440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RK78_RS03445	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RK78_RS03455	COG2423	ornithine cyclodeaminase activity
RK78_RS03460	COG4264	IucA IucC family
RK78_RS03465	COG2814	Major facilitator Superfamily
RK78_RS03470	COG4264	IucA IucC family
RK78_RS03475	COG4264	IucA IucC family
RK78_RS03485	COG0019	diaminopimelate decarboxylase activity
RK78_RS03490	COG1475	DNA binding
RK78_RS03515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RK78_RS03520	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RK78_RS03560	COG0813	purine-nucleoside phosphorylase activity
RK78_RS03565	COG2814	Major facilitator Superfamily
RK78_RS03585	COG3639	organic phosphonate transmembrane transporter activity
RK78_RS03605	COG0737	Belongs to the 5'-nucleotidase family
RK78_RS03620	COG1454	alcohol dehydrogenase
RK78_RS03620	COG1012	belongs to the aldehyde dehydrogenase family
RK78_RS03645	COG1086	Polysaccharide biosynthesis protein
RK78_RS03655	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
RK78_RS03685	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RK78_RS03695	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
RK78_RS03700	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
RK78_RS03710	COG2832	Protein of unknown function (DUF454)
RK78_RS03745	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RK78_RS03750	COG1960	acyl-CoA dehydrogenase activity
RK78_RS03755	COG5609	conserved protein (DUF2294)
RK78_RS03805	COG1114	Component of the transport system for branched-chain amino acids
RK78_RS03810	COG1335	isochorismatase
RK78_RS03815	COG3961	Belongs to the TPP enzyme family
RK78_RS03845	COG1737	Transcriptional regulator
RK78_RS03875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RK78_RS03885	COG0405	Gamma-glutamyltransferase
RK78_RS03900	COG3842	ATPase activity
RK78_RS03910	COG1175	transmembrane transport
RK78_RS03915	COG3833	ABC-type maltose transport systems, permease component
RK78_RS03920	COG0673	inositol 2-dehydrogenase activity
RK78_RS03925	COG0673	inositol 2-dehydrogenase activity
RK78_RS03935	COG1755	Isoprenylcysteine carboxyl methyltransferase
RK78_RS03990	COG0183	Belongs to the thiolase family
RK78_RS04000	COG1960	acyl-CoA dehydrogenase activity
RK78_RS04005	COG0318	PFAM AMP-dependent synthetase and ligase
RK78_RS04025	COG0747	negative chemotaxis
RK78_RS04030	COG3189	MarR family transcriptional regulator
RK78_RS04065	COG2190	(PTS) system
RK78_RS04065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RK78_RS04065	COG1263	PTS System
RK78_RS04070	COG1957	nucleoside hydrolase
RK78_RS04090	COG3414	Phosphotransferase system galactitol-specific IIB component
RK78_RS04095	COG3775	system Galactitol-specific IIC component
RK78_RS04100	COG1063	alcohol dehydrogenase
RK78_RS04110	COG1063	alcohol dehydrogenase
RK78_RS04120	COG1063	alcohol dehydrogenase
RK78_RS04125	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
RK78_RS04135	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
RK78_RS04145	COG1063	alcohol dehydrogenase
RK78_RS04150	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
RK78_RS04190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RK78_RS04200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RK78_RS04200	COG1263	PTS System
RK78_RS04200	COG2190	(PTS) system
RK78_RS04205	COG2723	6-phospho-beta-galactosidase activity
RK78_RS04215	COG2226	methyltransferase
RK78_RS04265	COG1131	(ABC) transporter
RK78_RS04285	COG1388	LysM domain
RK78_RS04285	COG3942	CHAP domain
RK78_RS04430	COG1114	Component of the transport system for branched-chain amino acids
RK78_RS04440	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
RK78_RS04450	COG0577	efflux transmembrane transporter activity
RK78_RS04480	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
RK78_RS04485	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RK78_RS04535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RK78_RS04565	COG3037	sugar-specific permease SgaT UlaA
RK78_RS04575	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RK78_RS04580	COG3711	transcriptional antiterminator
RK78_RS04605	COG2271	Major facilitator Superfamily
RK78_RS04610	COG0346	lactoylglutathione lyase activity
RK78_RS04615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RK78_RS04635	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RK78_RS04640	COG2822	iron ion transport
RK78_RS04650	COG0672	)-iron permease
RK78_RS04655	COG0805	protein transport
RK78_RS04660	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RK78_RS04670	COG1476	TRANSCRIPTIONal
RK78_RS04680	COG1131	(ABC) transporter
RK78_RS04710	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
RK78_RS04710	COG0646	methionine synthase
RK78_RS04715	COG0626	cystathionine gamma-synthase activity
RK78_RS04720	COG0626	cystathionine gamma-synthase activity
RK78_RS04730	COG1475	DNA binding
RK78_RS04735	COG0668	transmembrane transport
RK78_RS04740	COG4481	Protein conserved in bacteria
RK78_RS04745	COG0012	GTP binding
RK78_RS04845	COG1823	symporter activity
RK78_RS04880	COG2233	PERMEase
RK78_RS04925	COG3759	membrane
RK78_RS05065	COG0523	cobalamin synthesis protein
RK78_RS05090	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RK78_RS05100	COG5609	conserved protein (DUF2294)
RK78_RS05115	COG1647	Serine aminopeptidase, S33
RK78_RS05125	COG0733	neurotransmitter:sodium symporter activity
RK78_RS05130	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RK78_RS05135	COG0626	cystathionine gamma-synthase activity
RK78_RS05145	COG2011	ABC-type metal ion transport system permease component
RK78_RS05150	COG1464	Belongs to the NlpA lipoprotein family
RK78_RS05185	COG0583	DNA-binding transcription factor activity
RK78_RS05190	COG0069	glutamate synthase activity
RK78_RS05190	COG0070	glutamate synthase
RK78_RS05190	COG0067	glutamate synthase
RK78_RS05195	COG0493	'glutamate synthase
RK78_RS05205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RK78_RS05205	COG1263	PTS System
RK78_RS05210	COG0366	Alpha amylase catalytic
RK78_RS05215	COG2188	Transcriptional regulator
RK78_RS05235	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RK78_RS05270	COG1982	Orn Lys Arg decarboxylase major
RK78_RS05280	COG3870	Protein conserved in bacteria
RK78_RS05285	COG0470	DNA polymerase III
RK78_RS05290	COG1774	PSP1 C-terminal conserved region
RK78_RS05300	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
RK78_RS05310	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
RK78_RS05320	COG0084	hydrolase, TatD family'
RK78_RS05325	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
RK78_RS05335	COG4466	Protein conserved in bacteria
RK78_RS05345	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RK78_RS05350	COG0251	oxidation-reduction process
RK78_RS05395	COG2244	polysaccharide biosynthetic process
RK78_RS05400	COG3956	TIGRFAM MazG family protein
RK78_RS05405	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
RK78_RS05415	COG1098	S1 RNA binding domain
RK78_RS05430	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RK78_RS05455	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
RK78_RS05550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RK78_RS05570	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
RK78_RS05580	COG3880	PFAM UvrB UvrC protein
RK78_RS05595	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
RK78_RS05600	COG4956	integral membrane protein (PIN domain superfamily)
RK78_RS05625	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
RK78_RS05685	COG2813	Specifically methylates the guanine in position
RK78_RS05725	COG1473	amidohydrolase
RK78_RS05755	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
RK78_RS05760	COG1428	Deoxynucleoside kinase
RK78_RS05765	COG1428	Deoxynucleoside kinase
RK78_RS05775	COG0561	phosphatase activity
RK78_RS05795	COG4932	domain protein
RK78_RS05820	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
RK78_RS05935	COG0095	Lipoate-protein ligase
RK78_RS05940	COG0083	homoserine kinase activity
RK78_RS05960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RK78_RS05975	COG2826	transposase and inactivated derivatives, IS30 family
RK78_RS06005	COG0667	Aldo Keto reductase
RK78_RS06010	COG0655	NAD(P)H dehydrogenase (quinone) activity
RK78_RS06020	COG1078	dGTPase activity
RK78_RS06055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RK78_RS06060	COG4139	cobalamin transport
RK78_RS06155	COG2814	Major facilitator Superfamily
RK78_RS06165	COG0803	Belongs to the bacterial solute-binding protein 9 family
RK78_RS06170	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RK78_RS06175	COG1121	(ABC) transporter
RK78_RS06180	COG1321	iron dependent repressor
RK78_RS06200	COG1682	transport, permease protein
RK78_RS06205	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
RK78_RS06215	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
RK78_RS06220	COG1686	Belongs to the peptidase S11 family
RK78_RS06225	COG1132	(ABC) transporter
RK78_RS06230	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
RK78_RS06240	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
RK78_RS06245	COG2826	transposase and inactivated derivatives, IS30 family
RK78_RS06250	COG1120	ATPase activity
RK78_RS06255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RK78_RS06260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RK78_RS06265	COG2376	Dihydroxyacetone kinase
RK78_RS06285	COG3949	Membrane
RK78_RS06310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RK78_RS06325	COG1136	(ABC) transporter
RK78_RS06330	COG0577	efflux transmembrane transporter activity
RK78_RS06335	COG1392	Phosphate transport regulator
RK78_RS06340	COG0306	phosphate transporter
RK78_RS06345	COG1388	LysM domain
RK78_RS06345	COG3942	CHAP domain
RK78_RS06355	COG4977	sequence-specific DNA binding
RK78_RS06355	COG1917	Cupin 2, conserved barrel domain protein
RK78_RS06385	COG0583	DNA-binding transcription factor activity
RK78_RS06390	COG2814	Major facilitator Superfamily
RK78_RS06395	COG2839	Protein conserved in bacteria
RK78_RS06430	COG1611	Belongs to the LOG family
RK78_RS06450	COG4988	ABC transporter
RK78_RS06455	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
RK78_RS06465	COG0523	cobalamin synthesis protein
RK78_RS06470	COG4989	oxidoreductase activity
RK78_RS06480	COG0471	metal ion transport
RK78_RS06515	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RK78_RS06520	COG1349	DNA-binding transcription factor activity
RK78_RS06525	COG1105	Belongs to the carbohydrate kinase PfkB family
RK78_RS06530	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RK78_RS06530	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RK78_RS06530	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RK78_RS06535	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
RK78_RS06540	COG1253	flavin adenine dinucleotide binding
RK78_RS06545	COG0656	L-ascorbic acid biosynthetic process
RK78_RS06550	COG0463	Glycosyl transferase, family 2
RK78_RS06585	COG0720	synthase
RK78_RS06595	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RK78_RS06595	COG0512	Glutamine amidotransferase of anthranilate synthase
RK78_RS06600	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RK78_RS06630	COG0488	(ABC) transporter
RK78_RS06635	COG0514	ATP-dependent DNA helicase (RecQ)
RK78_RS06640	COG1125	glycine betaine transport
RK78_RS06640	COG0517	IMP dehydrogenase activity
RK78_RS06645	COG1174	glycine betaine transport
RK78_RS06670	COG3104	oligopeptide transport
RK78_RS06700	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RK78_RS06705	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RK78_RS06710	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RK78_RS06715	COG4605	iron ion homeostasis
RK78_RS06720	COG4604	ABC transporter, ATP-binding protein
RK78_RS06725	COG4607	ABC-type enterochelin transport system periplasmic component
RK78_RS06780	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RK78_RS06785	COG1739	Uncharacterized protein family UPF0029
RK78_RS06795	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
RK78_RS06800	COG1040	competence protein
RK78_RS06825	COG3942	CHAP domain
RK78_RS06825	COG1388	LysM domain
RK78_RS06890	COG0391	Required for morphogenesis under gluconeogenic growth conditions
RK78_RS06910	COG0281	malic enzyme
RK78_RS06960	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RK78_RS06965	COG1647	Serine aminopeptidase, S33
RK78_RS06970	COG0557	exoribonuclease II activity
RK78_RS07035	COG1278	Cold shock
RK78_RS07075	COG0406	alpha-ribazole phosphatase activity
RK78_RS07080	COG1279	arginine transmembrane transporter activity
RK78_RS07105	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RK78_RS07110	COG1393	Belongs to the ArsC family
RK78_RS07125	COG3878	Protein conserved in bacteria
RK78_RS07130	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
RK78_RS07145	COG2011	ABC-type metal ion transport system permease component
RK78_RS07150	COG1464	Belongs to the NlpA lipoprotein family
RK78_RS07245	COG5484	DNA packaging
RK78_RS07245	COG3728	DNA packaging
RK78_RS07300	COG0396	ATPase activity
RK78_RS07305	COG0719	Fe-S assembly protein
RK78_RS07315	COG0822	iron-sulfur transferase activity
RK78_RS07335	COG1253	flavin adenine dinucleotide binding
RK78_RS07345	COG1801	Protein of unknown function DUF72
RK78_RS07350	COG0730	response to heat
RK78_RS07365	COG4470	Protein conserved in bacteria
RK78_RS07375	COG2445	Protein of unknown function DUF86
RK78_RS07405	COG1696	Membrane protein involved in D-alanine export
RK78_RS07415	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
RK78_RS07420	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
RK78_RS07425	COG4837	Protein of unknown function (DUF1462)
RK78_RS07430	COG1252	NADH dehydrogenase
RK78_RS07440	COG0316	Belongs to the HesB IscA family
RK78_RS07450	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RK78_RS07455	COG2056	Na+-H+ antiporter family
RK78_RS07460	COG2050	protein possibly involved in aromatic compounds catabolism
RK78_RS07515	COG1098	S1 RNA binding domain
RK78_RS07520	COG1902	pentaerythritol trinitrate reductase activity
RK78_RS07535	COG0584	glycerophosphoryl diester phosphodiesterase
RK78_RS07555	COG0398	Pfam SNARE associated Golgi protein
RK78_RS07600	COG0561	phosphatase activity
RK78_RS07615	COG2826	transposase and inactivated derivatives, IS30 family
RK78_RS07645	COG1674	ftsk spoiiie
RK78_RS07650	COG0433	COG0433 Predicted ATPase
RK78_RS07670	COG2946	Replication initiation factor
RK78_RS07700	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RK78_RS07715	COG1881	PFAM PEBP family protein
RK78_RS07745	COG0601	transmembrane transport
RK78_RS07750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RK78_RS07755	COG0444	Belongs to the ABC transporter superfamily
RK78_RS07760	COG4608	Belongs to the ABC transporter superfamily
RK78_RS07765	COG4166	transmembrane transport
RK78_RS07775	COG2826	transposase and inactivated derivatives, IS30 family
RK78_RS07780	COG0747	negative chemotaxis
RK78_RS07785	COG0444	Belongs to the ABC transporter superfamily
RK78_RS07790	COG4608	Belongs to the ABC transporter superfamily
RK78_RS07795	COG0601	transmembrane transport
RK78_RS07800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RK78_RS07835	COG1164	Oligoendopeptidase f
RK78_RS07845	COG2346	COG2346, Truncated hemoglobins
RK78_RS07860	COG2357	RelA SpoT domain protein
RK78_RS07870	COG0564	pseudouridine synthase activity
RK78_RS07875	COG2239	Acts as a magnesium transporter
RK78_RS07880	COG0475	glutathione-regulated potassium exporter activity
RK78_RS07880	COG0569	domain protein
RK78_RS07890	COG0628	permease
RK78_RS07895	COG1115	amino acid carrier protein
RK78_RS07945	COG0861	Integral membrane protein TerC family
RK78_RS07955	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RK78_RS07960	COG0737	Belongs to the 5'-nucleotidase family
RK78_RS07975	COG4903	ComK protein
RK78_RS07990	COG4873	Protein conserved in bacteria
RK78_RS08050	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
RK78_RS08060	COG2314	TM2 domain
RK78_RS08065	COG0456	acetyltransferase
RK78_RS08070	COG1575	Belongs to the MenA family. Type 1 subfamily
RK78_RS08080	COG1169	isochorismate synthase
RK78_RS08090	COG2267	carboxylic ester hydrolase activity
RK78_RS08120	COG0436	Aminotransferase
RK78_RS08125	COG3594	Acyltransferase
RK78_RS08155	COG1316	TRANSCRIPTIONal
RK78_RS08205	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
RK78_RS08220	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RK78_RS08265	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
RK78_RS08270	COG4172	Belongs to the ABC transporter superfamily
RK78_RS08275	COG4721	ABC-type cobalt transport system, permease component
RK78_RS08295	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
RK78_RS08320	COG1271	oxidase subunit
RK78_RS08325	COG1294	oxidase, subunit
RK78_RS08330	COG0569	domain protein
RK78_RS08400	COG1176	ABC-type spermidine putrescine transport system, permease component I
RK78_RS08405	COG1177	transmembrane transport
RK78_RS08410	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
RK78_RS08435	COG0483	inositol monophosphate 1-phosphatase activity
RK78_RS08455	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RK78_RS08465	COG0772	Belongs to the SEDS family
RK78_RS08495	COG2340	Cysteine-rich secretory protein family
RK78_RS08500	COG3679	Belongs to the UPF0342 family
RK78_RS08505	COG0584	glycerophosphoryl diester phosphodiesterase
RK78_RS08520	COG0742	ribosomal rna small subunit methyltransferase
RK78_RS08580	COG4509	Sortase family
RK78_RS08595	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RK78_RS08630	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
RK78_RS08630	COG1796	DNA polymerase
RK78_RS08655	COG2009	succinate dehydrogenase
RK78_RS08660	COG1053	succinate dehydrogenase
RK78_RS08665	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RK78_RS08785	COG1288	antiporter activity
RK78_RS08815	COG1011	Hydrolase
RK78_RS08840	COG4839	cell division protein FtsL
RK78_RS08880	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
RK78_RS08890	COG0762	integral membrane protein
RK78_RS08895	COG2302	S4 RNA-binding domain
RK78_RS08900	COG3599	regulation of cell shape
RK78_RS08910	COG2826	transposase and inactivated derivatives, IS30 family
RK78_RS08915	COG2514	catechol 2,3-dioxygenase activity
RK78_RS08925	COG0564	pseudouridine synthase activity
RK78_RS08935	COG2233	PERMEase
RK78_RS08980	COG1293	RNA-binding protein homologous to eukaryotic snRNP
RK78_RS08995	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
RK78_RS09000	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
RK78_RS09010	COG2314	TM2 domain
RK78_RS09025	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RK78_RS09025	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RK78_RS09035	COG0631	protein serine/threonine phosphatase activity
RK78_RS09050	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RK78_RS09065	COG1302	Protein conserved in bacteria
RK78_RS09115	COG1196	nuclear chromosome segregation
RK78_RS09120	COG0552	protein localization to endoplasmic reticulum
RK78_RS09130	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
RK78_RS09195	COG0758	DNA mediated transformation
RK78_RS09295	COG0195	Participates in both transcription termination and antitermination
RK78_RS09300	COG2740	Nucleic-acid-binding protein implicated in transcription termination
RK78_RS09325	COG0196	riboflavin kinase activity
RK78_RS09355	COG2188	Transcriptional regulator
RK78_RS09360	COG0612	Peptidase, M16
RK78_RS09365	COG0612	Peptidase, M16
RK78_RS09370	COG0300	oxidoreductase activity
RK78_RS09390	COG1546	Belongs to the CinA family
RK78_RS09390	COG1058	Belongs to the CinA family
RK78_RS09410	COG1692	metallophosphoesterase
RK78_RS09415	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
RK78_RS09415	COG0674	pyruvate-flavodoxin oxidoreductase activity
RK78_RS09420	COG1013	pyruvate-flavodoxin oxidoreductase activity
RK78_RS09455	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
RK78_RS09460	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RK78_RS09485	COG1923	regulation of RNA biosynthetic process
RK78_RS09500	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
RK78_RS09505	COG0789	Transcriptional regulator
RK78_RS09540	COG2826	transposase and inactivated derivatives, IS30 family
RK78_RS09650	COG1131	(ABC) transporter
RK78_RS09665	COG2197	response regulator
RK78_RS09680	COG1525	nuclease
RK78_RS09695	COG0527	aspartate kinase activity
RK78_RS09700	COG0460	homoserine dehydrogenase
RK78_RS09705	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
RK78_RS09730	COG0833	amino acid
RK78_RS09795	COG4846	Membrane protein involved in cytochrome C biogenesis
RK78_RS09815	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RK78_RS09825	COG0824	Thioesterase
RK78_RS09865	COG1115	amino acid carrier protein
RK78_RS09880	COG0628	permease
RK78_RS09910	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RK78_RS09920	COG1363	Peptidase, m42
RK78_RS09925	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RK78_RS09930	COG0512	Glutamine amidotransferase of anthranilate synthase
RK78_RS10015	COG0704	Plays a role in the regulation of phosphate uptake
RK78_RS10025	COG0581	inorganic phosphate transmembrane transporter activity
RK78_RS10030	COG0573	inorganic phosphate transmembrane transporter activity
RK78_RS10045	COG0488	(ABC) transporter
RK78_RS10050	COG0527	aspartate kinase activity
RK78_RS10055	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RK78_RS10130	COG4548	von Willebrand factor, type A
RK78_RS10135	COG0714	Associated with various cellular activities
RK78_RS10180	COG0671	phosphoesterase, PA-phosphatase related
RK78_RS10200	COG2826	transposase and inactivated derivatives, IS30 family
RK78_RS10260	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
RK78_RS10280	COG0531	amino acid
RK78_RS10295	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RK78_RS10300	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
RK78_RS10320	COG0116	Belongs to the methyltransferase superfamily
RK78_RS10355	COG4499	WXG100 protein secretion system (Wss), protein YukC
RK78_RS10355	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RK78_RS10365	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
RK78_RS10370	COG3935	DnaD domain protein
RK78_RS10395	COG0438	transferase activity, transferring glycosyl groups
RK78_RS10400	COG1694	Mazg nucleotide pyrophosphohydrolase
RK78_RS10405	COG2738	Putative neutral zinc metallopeptidase
RK78_RS10410	COG4347	Protein of unknown function (DUF1405)
RK78_RS10445	COG0142	geranyltranstransferase activity
RK78_RS10510	COG0492	ferredoxin-NADP+ reductase activity
RK78_RS10525	COG0514	ATP-dependent DNA helicase (RecQ)
RK78_RS10535	COG1141	Ferredoxin
RK78_RS10585	COG1388	LysM domain
RK78_RS10585	COG0860	N-Acetylmuramoyl-L-alanine amidase
RK78_RS10635	COG5412	phage tail tape measure protein
RK78_RS10635	COG3953	SLT domain
RK78_RS10760	COG0756	dUTP diphosphatase activity
RK78_RS10855	COG3646	Phage regulatory protein
RK78_RS10855	COG3645	SOS response
RK78_RS10890	COG0582	viral genome integration into host DNA
RK78_RS10910	COG0745	RESPONSE REGULATOR receiver
RK78_RS10915	COG1187	pseudouridine synthase activity
RK78_RS10940	COG0735	belongs to the Fur family
RK78_RS10945	COG0494	nUDIX hydrolase
RK78_RS10950	COG0667	Aldo Keto reductase
RK78_RS10960	COG4221	oxidoreductase activity
RK78_RS10975	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
RK78_RS10985	COG0366	Alpha amylase catalytic
RK78_RS10990	COG1609	Transcriptional regulator
RK78_RS11020	COG2195	Cleaves the N-terminal amino acid of tripeptides
RK78_RS11030	COG4129	membrane
RK78_RS11040	COG0508	dehydrogenase complex catalyzes the overall conversion of
RK78_RS11045	COG0022	dehydrogenase e1 component
RK78_RS11050	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
RK78_RS11055	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RK78_RS11060	COG0497	DNA recombination
RK78_RS11090	COG1302	Protein conserved in bacteria
RK78_RS11095	COG0439	Biotin carboxylase
RK78_RS11100	COG0511	ligase activity, forming carbon-carbon bonds
RK78_RS11110	COG0006	proline dipeptidase activity
RK78_RS11125	COG0095	Lipoate-protein ligase
RK78_RS11130	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RK78_RS11175	COG4537	Required for transformation and DNA binding
RK78_RS11180	COG1459	type II secretion system
RK78_RS11185	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RK78_RS11190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RK78_RS11195	COG0011	TIGRFAM Protein of
RK78_RS11200	COG1940	carbohydrate kinase activity
RK78_RS11205	COG4483	Protein conserved in bacteria
RK78_RS11215	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
RK78_RS11240	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RK78_RS11245	COG1121	(ABC) transporter
RK78_RS11255	COG0513	Belongs to the DEAD box helicase family
RK78_RS11265	COG2384	SAM-dependent methyltransferase
RK78_RS11285	COG0517	IMP dehydrogenase activity
RK78_RS11305	COG0295	cytidine deaminase activity
RK78_RS11320	COG1702	phosphate starvation-inducible protein PhoH
RK78_RS11335	COG1030	water channel activity
RK78_RS11345	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RK78_RS11350	COG1385	rRNA (uridine-N3-)-methyltransferase activity
RK78_RS11380	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RK78_RS11400	COG1466	dna polymerase III delta subunit
RK78_RS11405	COG0658	competence protein
RK78_RS11405	COG2333	competence protein COMEC
RK78_RS11410	COG2131	deaminase
RK78_RS11420	COG2226	methyltransferase
RK78_RS11425	COG0799	negative regulation of ribosome biogenesis
RK78_RS11430	COG1713	HD superfamily hydrolase involved in NAD metabolism
RK78_RS11440	COG1534	Rna-binding protein
RK78_RS11450	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
RK78_RS11455	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
RK78_RS11480	COG3177	Filamentation induced by cAMP protein fic
RK78_RS11485	COG1914	H( )-stimulated, divalent metal cation uptake system
RK78_RS11495	COG0439	Biotin carboxylase
RK78_RS11500	COG0511	ligase activity, forming carbon-carbon bonds
RK78_RS11505	COG1984	allophanate hydrolase subunit 2
RK78_RS11510	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
RK78_RS11560	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RK78_RS11575	COG1104	cysteine desulfurase activity
RK78_RS11580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RK78_RS11590	COG3237	CsbD-like
RK78_RS11595	COG1959	2 iron, 2 sulfur cluster binding
RK78_RS11600	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
RK78_RS11605	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
RK78_RS11650	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
RK78_RS11650	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
RK78_RS11655	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RK78_RS11655	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RK78_RS11660	COG1862	Preprotein translocase
RK78_RS11700	COG2868	ribosomal protein
RK78_RS11745	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
RK78_RS11755	COG0285	dihydrofolate synthase activity
RK78_RS11765	COG2818	Glycosylase
RK78_RS11800	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RK78_RS11835	COG4112	unkown
RK78_RS11860	COG0833	amino acid
RK78_RS11875	COG1484	DNA-dependent DNA replication
RK78_RS11905	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RK78_RS11905	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RK78_RS11915	COG5002	protein histidine kinase activity
RK78_RS11920	COG0745	RESPONSE REGULATOR receiver
RK78_RS11935	COG0372	Belongs to the citrate synthase family
RK78_RS11940	COG1113	amino acid transport
RK78_RS11965	COG0281	malic enzyme
RK78_RS11975	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
RK78_RS11980	COG4109	DRTGG domain
RK78_RS12020	COG0827	DNA restriction-modification system
RK78_RS12030	COG0730	response to heat
RK78_RS12040	COG1104	cysteine desulfurase activity
RK78_RS12055	COG1956	GAF domain-containing protein
RK78_RS12075	COG0584	glycerophosphoryl diester phosphodiesterase
RK78_RS12080	COG1764	response to oxidative stress
RK78_RS12085	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
RK78_RS12090	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RK78_RS12105	COG1263	PTS System
RK78_RS12105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RK78_RS12110	COG0204	Acyl-transferase
RK78_RS12115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RK78_RS12145	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RK78_RS12150	COG0454	-acetyltransferase
RK78_RS12170	COG1605	Chorismate mutase
RK78_RS12170	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
RK78_RS12195	COG1674	ftsk spoiiie
RK78_RS12200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RK78_RS12210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RK78_RS12215	COG1363	Peptidase, m42
RK78_RS12225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RK78_RS12235	COG0510	thiamine kinase activity
RK78_RS12255	COG1187	pseudouridine synthase activity
RK78_RS12260	COG2244	polysaccharide biosynthetic process
RK78_RS12265	COG2081	HI0933 family
RK78_RS12285	COG2814	Major facilitator Superfamily
RK78_RS12290	COG1242	4 iron, 4 sulfur cluster binding
RK78_RS12295	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
RK78_RS12305	COG2267	carboxylic ester hydrolase activity
RK78_RS12340	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RK78_RS12340	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RK78_RS12360	COG5632	N-Acetylmuramoyl-L-alanine amidase
RK78_RS12360	COG4193	domain, Protein
RK78_RS12360	COG3266	domain, Protein
RK78_RS12395	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RK78_RS12415	COG0656	L-ascorbic acid biosynthetic process
RK78_RS12440	COG2816	NAD+ diphosphatase activity
RK78_RS12530	COG5492	domain, Protein
RK78_RS12755	COG1131	(ABC) transporter
RK78_RS12760	COG0537	adenosine 5'-monophosphoramidase activity
RK78_RS12790	COG0420	3'-5' exonuclease activity
RK78_RS12815	COG2197	response regulator
RK78_RS12820	COG2203	Gaf domain
RK78_RS12820	COG4585	Histidine kinase
RK78_RS12825	COG0564	pseudouridine synthase activity
RK78_RS12855	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
RK78_RS12860	COG1126	abc transporter atp-binding protein
RK78_RS12865	COG0765	amino acid transport
RK78_RS13030	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RK78_RS13035	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RK78_RS13045	COG4129	membrane
RK78_RS13060	COG1194	a g-specific adenine glycosylase
RK78_RS13065	COG1988	membrane-bound metal-dependent
RK78_RS13080	COG1134	teichoic acid transport
RK78_RS13080	COG1388	LysM domain
RK78_RS13110	COG0535	radical SAM domain protein
RK78_RS13115	COG1607	acyl-coa hydrolase
RK78_RS13120	COG2309	aminopeptidase activity
RK78_RS13140	COG1295	ribonuclease BN
RK78_RS13260	COG4851	CamS sex pheromone cAM373 precursor
RK78_RS13280	COG4496	protein, YerC YecD
RK78_RS13315	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
RK78_RS13325	COG0077	Prephenate dehydratase
RK78_RS13345	COG1335	isochorismatase
RK78_RS13360	COG1012	belongs to the aldehyde dehydrogenase family
RK78_RS13410	COG1131	(ABC) transporter
RK78_RS13425	COG1725	Transcriptional regulator
RK78_RS13480	COG0860	N-Acetylmuramoyl-L-alanine amidase
RK78_RS13480	COG1388	LysM domain
RK78_RS13495	COG1388	LysM domain
RK78_RS13495	COG5632	N-Acetylmuramoyl-L-alanine amidase
RK78_RS13540	COG0739	heme binding
RK78_RS13595	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RK78_RS13675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RK78_RS13680	COG1621	beta-fructofuranosidase activity
RK78_RS13685	COG1609	Transcriptional regulator
RK78_RS13690	COG0004	ammonium transporteR
RK78_RS13695	COG0425	Belongs to the sulfur carrier protein TusA family
RK78_RS13700	COG2391	methyltransferase activity
RK78_RS13710	COG0488	(ABC) transporter
RK78_RS13720	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
RK78_RS13730	COG0456	acetyltransferase
RK78_RS13735	COG1214	PFAM Peptidase M22, glycoprotease
RK78_RS13740	COG0802	atpase or kinase
RK78_RS13755	COG0028	Belongs to the TPP enzyme family
RK78_RS13840	COG2183	response to ionizing radiation
RK78_RS13845	COG1191	sigma factor activity
RK78_RS13855	COG1366	Belongs to the anti-sigma-factor antagonist family
RK78_RS13860	COG2208	phosphoserine phosphatase activity
RK78_RS13895	COG3428	Bacterial PH domain
RK78_RS13925	COG2205	protein histidine kinase activity
RK78_RS13930	COG0745	RESPONSE REGULATOR receiver
RK78_RS13940	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
RK78_RS13950	COG0772	Belongs to the SEDS family
RK78_RS13970	COG1937	Protein conserved in bacteria
RK78_RS13980	COG1418	mRNA catabolic process
RK78_RS14035	COG0629	single-stranded DNA binding
RK78_RS14115	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
RK78_RS14140	COG0009	L-threonylcarbamoyladenylate synthase
RK78_RS14145	COG2890	protein-(glutamine-N5) methyltransferase activity
RK78_RS14170	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
RK78_RS14210	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RK78_RS14260	COG0813	purine-nucleoside phosphorylase activity
RK78_RS14265	COG0783	Belongs to the Dps family
RK78_RS14285	COG1482	cell wall glycoprotein biosynthetic process
RK78_RS14290	COG0702	epimerase
RK78_RS14295	COG0640	Transcriptional regulator
RK78_RS14330	COG0561	phosphatase activity
RK78_RS14335	COG1119	ATPase activity
RK78_RS14355	COG3711	transcriptional antiterminator