locus-tag	class	description
FORC45_RS00015	COG2501	S4 domain
FORC45_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FORC45_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FORC45_RS00065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FORC45_RS00075	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
FORC45_RS00085	COG0305	Participates in initiation and elongation during chromosome replication
FORC45_RS00120	COG4863	YycH protein
FORC45_RS00130	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FORC45_RS00135	COG0737	Belongs to the 5'-nucleotidase family
FORC45_RS00280	COG0456	acetyltransferase
FORC45_RS00300	COG0730	response to heat
FORC45_RS00305	COG1937	Protein conserved in bacteria
FORC45_RS00310	COG2210	Belongs to the sulfur carrier protein TusA family
FORC45_RS00315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FORC45_RS00365	COG0655	NAD(P)H dehydrogenase (quinone) activity
FORC45_RS00390	COG0583	DNA-binding transcription factor activity
FORC45_RS00410	COG0823	Involved in the tonB-independent uptake of proteins
FORC45_RS00455	COG1473	amidohydrolase
FORC45_RS00465	COG1283	sodium-dependent phosphate transmembrane transporter activity
FORC45_RS00470	COG4716	Myosin-crossreactive antigen
FORC45_RS00480	COG1620	l-lactate permease
FORC45_RS00500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC45_RS00505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC45_RS00510	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FORC45_RS00520	COG2423	ornithine cyclodeaminase activity
FORC45_RS00525	COG4264	IucA IucC family
FORC45_RS00530	COG2814	Major facilitator Superfamily
FORC45_RS00535	COG4264	IucA IucC family
FORC45_RS00540	COG4264	IucA IucC family
FORC45_RS00550	COG0019	diaminopimelate decarboxylase activity
FORC45_RS00555	COG1475	DNA binding
FORC45_RS00585	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FORC45_RS00590	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FORC45_RS00595	COG0438	transferase activity, transferring glycosyl groups
FORC45_RS00625	COG0813	purine-nucleoside phosphorylase activity
FORC45_RS00630	COG2814	Major facilitator Superfamily
FORC45_RS00650	COG3639	organic phosphonate transmembrane transporter activity
FORC45_RS00670	COG0737	Belongs to the 5'-nucleotidase family
FORC45_RS00700	COG1454	alcohol dehydrogenase
FORC45_RS00700	COG1012	belongs to the aldehyde dehydrogenase family
FORC45_RS00750	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FORC45_RS00760	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FORC45_RS00765	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FORC45_RS00775	COG2832	Protein of unknown function (DUF454)
FORC45_RS00815	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FORC45_RS00820	COG1960	acyl-CoA dehydrogenase activity
FORC45_RS00825	COG5609	conserved protein (DUF2294)
FORC45_RS00875	COG1114	Component of the transport system for branched-chain amino acids
FORC45_RS00880	COG1335	isochorismatase
FORC45_RS00885	COG3961	Belongs to the TPP enzyme family
FORC45_RS00915	COG1737	Transcriptional regulator
FORC45_RS00940	COG1136	(ABC) transporter
FORC45_RS00945	COG0577	efflux transmembrane transporter activity
FORC45_RS00945	COG1136	(ABC) transporter
FORC45_RS00965	COG1131	(ABC) transporter
FORC45_RS00985	COG0601	transmembrane transport
FORC45_RS00990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC45_RS01000	COG0405	Gamma-glutamyltransferase
FORC45_RS01020	COG3842	ATPase activity
FORC45_RS01030	COG1175	transmembrane transport
FORC45_RS01035	COG3833	ABC-type maltose transport systems, permease component
FORC45_RS01040	COG0673	inositol 2-dehydrogenase activity
FORC45_RS01045	COG0673	inositol 2-dehydrogenase activity
FORC45_RS01055	COG1755	Isoprenylcysteine carboxyl methyltransferase
FORC45_RS01115	COG0183	Belongs to the thiolase family
FORC45_RS01125	COG1960	acyl-CoA dehydrogenase activity
FORC45_RS01130	COG0318	PFAM AMP-dependent synthetase and ligase
FORC45_RS01145	COG0747	negative chemotaxis
FORC45_RS01150	COG3189	MarR family transcriptional regulator
FORC45_RS01180	COG2190	(PTS) system
FORC45_RS01180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC45_RS01180	COG1263	PTS System
FORC45_RS01185	COG1957	nucleoside hydrolase
FORC45_RS01200	COG3414	Phosphotransferase system galactitol-specific IIB component
FORC45_RS01205	COG3775	system Galactitol-specific IIC component
FORC45_RS01210	COG1063	alcohol dehydrogenase
FORC45_RS01220	COG1063	alcohol dehydrogenase
FORC45_RS01230	COG1063	alcohol dehydrogenase
FORC45_RS01235	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FORC45_RS01240	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FORC45_RS01250	COG1063	alcohol dehydrogenase
FORC45_RS01255	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FORC45_RS01290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC45_RS01300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC45_RS01300	COG2190	(PTS) system
FORC45_RS01300	COG1263	PTS System
FORC45_RS01305	COG2723	6-phospho-beta-galactosidase activity
FORC45_RS01310	COG2226	methyltransferase
FORC45_RS01360	COG1131	(ABC) transporter
FORC45_RS01380	COG3942	CHAP domain
FORC45_RS01380	COG1388	LysM domain
FORC45_RS01510	COG1114	Component of the transport system for branched-chain amino acids
FORC45_RS01520	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
FORC45_RS01530	COG0577	efflux transmembrane transporter activity
FORC45_RS01560	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FORC45_RS01565	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FORC45_RS01590	COG3314	Sporulation integral membrane protein YlbJ
FORC45_RS01615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FORC45_RS01655	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC45_RS01660	COG3711	transcriptional antiterminator
FORC45_RS01685	COG2271	Major facilitator Superfamily
FORC45_RS01690	COG0346	lactoylglutathione lyase activity
FORC45_RS01695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FORC45_RS01700	COG0431	NADPH-dependent FMN reductase
FORC45_RS01715	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FORC45_RS01730	COG0672	)-iron permease
FORC45_RS01735	COG0805	protein transport
FORC45_RS01740	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FORC45_RS01750	COG1476	TRANSCRIPTIONal
FORC45_RS01760	COG1131	(ABC) transporter
FORC45_RS01790	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FORC45_RS01790	COG0646	methionine synthase
FORC45_RS01795	COG0626	cystathionine gamma-synthase activity
FORC45_RS01800	COG0626	cystathionine gamma-synthase activity
FORC45_RS01810	COG1475	DNA binding
FORC45_RS01815	COG0668	transmembrane transport
FORC45_RS01820	COG4481	Protein conserved in bacteria
FORC45_RS01825	COG0012	GTP binding
FORC45_RS01935	COG1823	symporter activity
FORC45_RS01970	COG2233	PERMEase
FORC45_RS02055	COG1683	Conserved Protein
FORC45_RS02065	COG3759	membrane
FORC45_RS02210	COG0523	cobalamin synthesis protein
FORC45_RS02225	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FORC45_RS02235	COG5609	conserved protein (DUF2294)
FORC45_RS02250	COG1647	Serine aminopeptidase, S33
FORC45_RS02260	COG0733	neurotransmitter:sodium symporter activity
FORC45_RS02265	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FORC45_RS02270	COG0626	cystathionine gamma-synthase activity
FORC45_RS02280	COG2011	ABC-type metal ion transport system permease component
FORC45_RS02285	COG1464	Belongs to the NlpA lipoprotein family
FORC45_RS02320	COG0583	DNA-binding transcription factor activity
FORC45_RS02325	COG0070	glutamate synthase
FORC45_RS02325	COG0069	glutamate synthase activity
FORC45_RS02325	COG0067	glutamate synthase
FORC45_RS02330	COG0493	'glutamate synthase
FORC45_RS02340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC45_RS02340	COG1263	PTS System
FORC45_RS02345	COG0366	Alpha amylase catalytic
FORC45_RS02350	COG2188	Transcriptional regulator
FORC45_RS02370	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FORC45_RS02410	COG1982	Orn Lys Arg decarboxylase major
FORC45_RS02420	COG3870	Protein conserved in bacteria
FORC45_RS02425	COG0470	DNA polymerase III
FORC45_RS02430	COG1774	PSP1 C-terminal conserved region
FORC45_RS02440	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FORC45_RS02450	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FORC45_RS02460	COG0084	hydrolase, TatD family'
FORC45_RS02465	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
FORC45_RS02475	COG4466	Protein conserved in bacteria
FORC45_RS02485	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FORC45_RS02490	COG0251	oxidation-reduction process
FORC45_RS02535	COG2244	polysaccharide biosynthetic process
FORC45_RS02540	COG3956	TIGRFAM MazG family protein
FORC45_RS02545	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FORC45_RS02555	COG1098	S1 RNA binding domain
FORC45_RS02570	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FORC45_RS02595	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FORC45_RS02675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC45_RS02690	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FORC45_RS02700	COG3880	PFAM UvrB UvrC protein
FORC45_RS02715	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FORC45_RS02720	COG4956	integral membrane protein (PIN domain superfamily)
FORC45_RS02745	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
FORC45_RS02805	COG2813	Specifically methylates the guanine in position
FORC45_RS02845	COG1473	amidohydrolase
FORC45_RS02875	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FORC45_RS02880	COG1428	Deoxynucleoside kinase
FORC45_RS02885	COG1428	Deoxynucleoside kinase
FORC45_RS02895	COG0561	phosphatase activity
FORC45_RS02940	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FORC45_RS03055	COG0095	Lipoate-protein ligase
FORC45_RS03060	COG0083	homoserine kinase activity
FORC45_RS03080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FORC45_RS03185	COG0667	Aldo Keto reductase
FORC45_RS03190	COG0655	NAD(P)H dehydrogenase (quinone) activity
FORC45_RS03200	COG1078	dGTPase activity
FORC45_RS03235	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FORC45_RS03240	COG4139	cobalamin transport
FORC45_RS03290	COG0456	acetyltransferase
FORC45_RS03325	COG4974	Belongs to the 'phage' integrase family
FORC45_RS03370	COG0803	Belongs to the bacterial solute-binding protein 9 family
FORC45_RS03375	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FORC45_RS03380	COG1121	(ABC) transporter
FORC45_RS03385	COG1321	iron dependent repressor
FORC45_RS03395	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
FORC45_RS03405	COG1682	transport, permease protein
FORC45_RS03410	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FORC45_RS03420	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FORC45_RS03425	COG1686	Belongs to the peptidase S11 family
FORC45_RS03430	COG1132	(ABC) transporter
FORC45_RS03435	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FORC45_RS03445	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FORC45_RS03450	COG1120	ATPase activity
FORC45_RS03455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC45_RS03460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC45_RS03465	COG2376	Dihydroxyacetone kinase
FORC45_RS03475	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
FORC45_RS03485	COG3949	Membrane
FORC45_RS03510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FORC45_RS03525	COG1136	(ABC) transporter
FORC45_RS03530	COG0577	efflux transmembrane transporter activity
FORC45_RS03535	COG1392	Phosphate transport regulator
FORC45_RS03540	COG0306	phosphate transporter
FORC45_RS03545	COG3942	CHAP domain
FORC45_RS03545	COG1388	LysM domain
FORC45_RS03555	COG1917	Cupin 2, conserved barrel domain protein
FORC45_RS03555	COG4977	sequence-specific DNA binding
FORC45_RS03585	COG0583	DNA-binding transcription factor activity
FORC45_RS03595	COG2814	Major facilitator Superfamily
FORC45_RS03600	COG2839	Protein conserved in bacteria
FORC45_RS03630	COG1611	Belongs to the LOG family
FORC45_RS03650	COG4988	ABC transporter
FORC45_RS03655	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FORC45_RS03670	COG4989	oxidoreductase activity
FORC45_RS03680	COG0471	metal ion transport
FORC45_RS03685	COG0415	Belongs to the DNA photolyase family
FORC45_RS03720	COG1349	DNA-binding transcription factor activity
FORC45_RS03725	COG1105	Belongs to the carbohydrate kinase PfkB family
FORC45_RS03730	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC45_RS03730	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC45_RS03730	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC45_RS03735	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FORC45_RS03740	COG1253	flavin adenine dinucleotide binding
FORC45_RS03745	COG0656	L-ascorbic acid biosynthetic process
FORC45_RS03750	COG0463	Glycosyl transferase, family 2
FORC45_RS03785	COG0720	synthase
FORC45_RS03795	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FORC45_RS03795	COG0512	Glutamine amidotransferase of anthranilate synthase
FORC45_RS03800	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FORC45_RS03830	COG0488	(ABC) transporter
FORC45_RS03835	COG0514	ATP-dependent DNA helicase (RecQ)
FORC45_RS03840	COG0517	IMP dehydrogenase activity
FORC45_RS03840	COG1125	glycine betaine transport
FORC45_RS03845	COG1174	glycine betaine transport
FORC45_RS03875	COG3104	oligopeptide transport
FORC45_RS03905	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FORC45_RS03910	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FORC45_RS03930	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC45_RS03935	COG4605	iron ion homeostasis
FORC45_RS03940	COG4604	ABC transporter, ATP-binding protein
FORC45_RS03945	COG4607	ABC-type enterochelin transport system periplasmic component
FORC45_RS04000	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FORC45_RS04005	COG1739	Uncharacterized protein family UPF0029
FORC45_RS04015	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
FORC45_RS04020	COG1040	competence protein
FORC45_RS04050	COG1388	LysM domain
FORC45_RS04050	COG3942	CHAP domain
FORC45_RS04110	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FORC45_RS04180	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FORC45_RS04185	COG1647	Serine aminopeptidase, S33
FORC45_RS04190	COG0557	exoribonuclease II activity
FORC45_RS04250	COG1278	Cold shock
FORC45_RS04290	COG0406	alpha-ribazole phosphatase activity
FORC45_RS04295	COG1279	arginine transmembrane transporter activity
FORC45_RS04320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FORC45_RS04325	COG1393	Belongs to the ArsC family
FORC45_RS04340	COG3878	Protein conserved in bacteria
FORC45_RS04345	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
FORC45_RS04360	COG2011	ABC-type metal ion transport system permease component
FORC45_RS04365	COG1464	Belongs to the NlpA lipoprotein family
FORC45_RS04380	COG0396	ATPase activity
FORC45_RS04385	COG0719	Fe-S assembly protein
FORC45_RS04395	COG0822	iron-sulfur transferase activity
FORC45_RS04420	COG1253	flavin adenine dinucleotide binding
FORC45_RS04430	COG1801	Protein of unknown function DUF72
FORC45_RS04435	COG0730	response to heat
FORC45_RS04450	COG4470	Protein conserved in bacteria
FORC45_RS04460	COG2445	Protein of unknown function DUF86
FORC45_RS04490	COG1696	Membrane protein involved in D-alanine export
FORC45_RS04500	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
FORC45_RS04505	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FORC45_RS04510	COG4837	Protein of unknown function (DUF1462)
FORC45_RS04515	COG1252	NADH dehydrogenase
FORC45_RS04525	COG0316	Belongs to the HesB IscA family
FORC45_RS04535	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FORC45_RS04540	COG2056	Na+-H+ antiporter family
FORC45_RS04545	COG2050	protein possibly involved in aromatic compounds catabolism
FORC45_RS04600	COG1098	S1 RNA binding domain
FORC45_RS04605	COG1902	pentaerythritol trinitrate reductase activity
FORC45_RS04625	COG0584	glycerophosphoryl diester phosphodiesterase
FORC45_RS04645	COG0398	Pfam SNARE associated Golgi protein
FORC45_RS04685	COG0561	phosphatase activity
FORC45_RS04710	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FORC45_RS04725	COG1881	PFAM PEBP family protein
FORC45_RS04755	COG0601	transmembrane transport
FORC45_RS04760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC45_RS04765	COG0444	Belongs to the ABC transporter superfamily
FORC45_RS04770	COG4608	Belongs to the ABC transporter superfamily
FORC45_RS04775	COG4166	transmembrane transport
FORC45_RS04780	COG0747	negative chemotaxis
FORC45_RS04785	COG0444	Belongs to the ABC transporter superfamily
FORC45_RS04790	COG4608	Belongs to the ABC transporter superfamily
FORC45_RS04795	COG0601	transmembrane transport
FORC45_RS04800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC45_RS04825	COG1164	Oligoendopeptidase f
FORC45_RS04835	COG2346	COG2346, Truncated hemoglobins
FORC45_RS04850	COG2357	RelA SpoT domain protein
FORC45_RS04860	COG0564	pseudouridine synthase activity
FORC45_RS04865	COG2239	Acts as a magnesium transporter
FORC45_RS04870	COG0569	domain protein
FORC45_RS04870	COG0475	glutathione-regulated potassium exporter activity
FORC45_RS04880	COG0628	permease
FORC45_RS04885	COG1115	amino acid carrier protein
FORC45_RS04925	COG0861	Integral membrane protein TerC family
FORC45_RS04935	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FORC45_RS04940	COG0737	Belongs to the 5'-nucleotidase family
FORC45_RS04955	COG4903	ComK protein
FORC45_RS04970	COG4873	Protein conserved in bacteria
FORC45_RS05035	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FORC45_RS05045	COG2314	TM2 domain
FORC45_RS05050	COG0456	acetyltransferase
FORC45_RS05055	COG1575	Belongs to the MenA family. Type 1 subfamily
FORC45_RS05065	COG1169	isochorismate synthase
FORC45_RS05075	COG2267	carboxylic ester hydrolase activity
FORC45_RS05100	COG0436	Aminotransferase
FORC45_RS05105	COG3594	Acyltransferase
FORC45_RS05135	COG1316	TRANSCRIPTIONal
FORC45_RS05180	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FORC45_RS05195	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FORC45_RS05225	COG0138	bifunctional purine biosynthesis protein purh
FORC45_RS05235	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
FORC45_RS05240	COG4172	Belongs to the ABC transporter superfamily
FORC45_RS05245	COG4721	ABC-type cobalt transport system, permease component
FORC45_RS05270	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FORC45_RS05290	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FORC45_RS05295	COG1271	oxidase subunit
FORC45_RS05300	COG1294	oxidase, subunit
FORC45_RS05305	COG0569	domain protein
FORC45_RS05370	COG1176	ABC-type spermidine putrescine transport system, permease component I
FORC45_RS05375	COG1177	transmembrane transport
FORC45_RS05380	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FORC45_RS05405	COG0483	inositol monophosphate 1-phosphatase activity
FORC45_RS05415	COG1217	gtp-binding protein TYPA
FORC45_RS05425	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FORC45_RS05435	COG0772	Belongs to the SEDS family
FORC45_RS05470	COG3679	Belongs to the UPF0342 family
FORC45_RS05490	COG0742	ribosomal rna small subunit methyltransferase
FORC45_RS05550	COG4509	Sortase family
FORC45_RS05565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FORC45_RS05600	COG1796	DNA polymerase
FORC45_RS05600	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FORC45_RS05625	COG2009	succinate dehydrogenase
FORC45_RS05630	COG1053	succinate dehydrogenase
FORC45_RS05635	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FORC45_RS05745	COG1288	antiporter activity
FORC45_RS05780	COG1011	Hydrolase
FORC45_RS05805	COG4839	cell division protein FtsL
FORC45_RS05810	COG0768	penicillin binding
FORC45_RS05825	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FORC45_RS05845	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FORC45_RS05855	COG0762	integral membrane protein
FORC45_RS05860	COG2302	S4 RNA-binding domain
FORC45_RS05865	COG3599	regulation of cell shape
FORC45_RS05875	COG2514	catechol 2,3-dioxygenase activity
FORC45_RS05890	COG0564	pseudouridine synthase activity
FORC45_RS05900	COG2233	PERMEase
FORC45_RS05945	COG1293	RNA-binding protein homologous to eukaryotic snRNP
FORC45_RS05960	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FORC45_RS05965	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FORC45_RS05975	COG2314	TM2 domain
FORC45_RS05990	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FORC45_RS05990	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FORC45_RS06000	COG0631	protein serine/threonine phosphatase activity
FORC45_RS06030	COG1302	Protein conserved in bacteria
FORC45_RS06090	COG0552	protein localization to endoplasmic reticulum
FORC45_RS06095	COG0552	protein localization to endoplasmic reticulum
FORC45_RS06175	COG0758	DNA mediated transformation
FORC45_RS06275	COG0195	Participates in both transcription termination and antitermination
FORC45_RS06280	COG2740	Nucleic-acid-binding protein implicated in transcription termination
FORC45_RS06305	COG0196	riboflavin kinase activity
FORC45_RS06335	COG2188	Transcriptional regulator
FORC45_RS06340	COG0612	Peptidase, M16
FORC45_RS06345	COG0612	Peptidase, M16
FORC45_RS06350	COG0300	oxidoreductase activity
FORC45_RS06370	COG1546	Belongs to the CinA family
FORC45_RS06370	COG1058	Belongs to the CinA family
FORC45_RS06390	COG1692	metallophosphoesterase
FORC45_RS06395	COG0674	pyruvate-flavodoxin oxidoreductase activity
FORC45_RS06395	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FORC45_RS06400	COG1013	pyruvate-flavodoxin oxidoreductase activity
FORC45_RS06435	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
FORC45_RS06440	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FORC45_RS06465	COG1923	regulation of RNA biosynthetic process
FORC45_RS06475	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FORC45_RS06480	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
FORC45_RS06485	COG0789	Transcriptional regulator
FORC45_RS06590	COG1131	(ABC) transporter
FORC45_RS06605	COG2197	response regulator
FORC45_RS06615	COG1525	nuclease
FORC45_RS06630	COG0527	aspartate kinase activity
FORC45_RS06635	COG0460	homoserine dehydrogenase
FORC45_RS06640	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FORC45_RS06665	COG0833	amino acid
FORC45_RS06695	COG2340	Cysteine-rich secretory protein family
FORC45_RS06730	COG4846	Membrane protein involved in cytochrome C biogenesis
FORC45_RS06750	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FORC45_RS06760	COG0824	Thioesterase
FORC45_RS06800	COG1115	amino acid carrier protein
FORC45_RS06815	COG0628	permease
FORC45_RS06840	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FORC45_RS06850	COG1363	Peptidase, m42
FORC45_RS06855	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FORC45_RS06860	COG0512	Glutamine amidotransferase of anthranilate synthase
FORC45_RS06960	COG0704	Plays a role in the regulation of phosphate uptake
FORC45_RS06970	COG0581	inorganic phosphate transmembrane transporter activity
FORC45_RS06975	COG0573	inorganic phosphate transmembrane transporter activity
FORC45_RS06995	COG0488	(ABC) transporter
FORC45_RS07005	COG0527	aspartate kinase activity
FORC45_RS07010	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FORC45_RS07090	COG4548	von Willebrand factor, type A
FORC45_RS07095	COG0714	Associated with various cellular activities
FORC45_RS07140	COG0671	phosphoesterase, PA-phosphatase related
FORC45_RS07220	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FORC45_RS07245	COG0531	amino acid
FORC45_RS07260	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC45_RS07265	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
FORC45_RS07285	COG0116	Belongs to the methyltransferase superfamily
FORC45_RS07325	COG4499	WXG100 protein secretion system (Wss), protein YukC
FORC45_RS07325	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FORC45_RS07335	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FORC45_RS07340	COG3935	DnaD domain protein
FORC45_RS07365	COG0438	transferase activity, transferring glycosyl groups
FORC45_RS07370	COG1694	Mazg nucleotide pyrophosphohydrolase
FORC45_RS07375	COG2738	Putative neutral zinc metallopeptidase
FORC45_RS07380	COG4347	Protein of unknown function (DUF1405)
FORC45_RS07430	COG0142	geranyltranstransferase activity
FORC45_RS07485	COG0492	ferredoxin-NADP+ reductase activity
FORC45_RS07500	COG0514	ATP-dependent DNA helicase (RecQ)
FORC45_RS07510	COG1141	Ferredoxin
FORC45_RS07540	COG0860	N-Acetylmuramoyl-L-alanine amidase
FORC45_RS07540	COG1388	LysM domain
FORC45_RS07590	COG5412	phage tail tape measure protein
FORC45_RS07590	COG3953	SLT domain
FORC45_RS07710	COG0756	dUTP diphosphatase activity
FORC45_RS07845	COG0582	viral genome integration into host DNA
FORC45_RS07860	COG5002	protein histidine kinase activity
FORC45_RS07865	COG0745	RESPONSE REGULATOR receiver
FORC45_RS07870	COG1187	pseudouridine synthase activity
FORC45_RS07895	COG0735	belongs to the Fur family
FORC45_RS07900	COG0494	nUDIX hydrolase
FORC45_RS07905	COG0667	Aldo Keto reductase
FORC45_RS07915	COG4221	oxidoreductase activity
FORC45_RS07930	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FORC45_RS07940	COG0366	Alpha amylase catalytic
FORC45_RS07945	COG1609	Transcriptional regulator
FORC45_RS07965	COG2195	Cleaves the N-terminal amino acid of tripeptides
FORC45_RS07975	COG4129	membrane
FORC45_RS07985	COG0508	dehydrogenase complex catalyzes the overall conversion of
FORC45_RS07990	COG0022	dehydrogenase e1 component
FORC45_RS07995	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FORC45_RS08000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FORC45_RS08005	COG0497	DNA recombination
FORC45_RS08035	COG1302	Protein conserved in bacteria
FORC45_RS08040	COG0439	Biotin carboxylase
FORC45_RS08045	COG0511	ligase activity, forming carbon-carbon bonds
FORC45_RS08055	COG0006	proline dipeptidase activity
FORC45_RS08070	COG0095	Lipoate-protein ligase
FORC45_RS08075	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORC45_RS08130	COG4537	Required for transformation and DNA binding
FORC45_RS08135	COG1459	type II secretion system
FORC45_RS08140	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC45_RS08145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FORC45_RS08150	COG0011	TIGRFAM Protein of
FORC45_RS08155	COG1940	carbohydrate kinase activity
FORC45_RS08160	COG4483	Protein conserved in bacteria
FORC45_RS08170	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FORC45_RS08180	COG0768	penicillin binding
FORC45_RS08195	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FORC45_RS08200	COG1121	(ABC) transporter
FORC45_RS08210	COG0513	Belongs to the DEAD box helicase family
FORC45_RS08220	COG2384	SAM-dependent methyltransferase
FORC45_RS08240	COG0517	IMP dehydrogenase activity
FORC45_RS08260	COG0295	cytidine deaminase activity
FORC45_RS08275	COG1702	phosphate starvation-inducible protein PhoH
FORC45_RS08290	COG1030	water channel activity
FORC45_RS08300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FORC45_RS08305	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FORC45_RS08335	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FORC45_RS08350	COG1466	dna polymerase III delta subunit
FORC45_RS08355	COG0658	competence protein
FORC45_RS08355	COG2333	competence protein COMEC
FORC45_RS08360	COG2131	deaminase
FORC45_RS08365	COG2183	response to ionizing radiation
FORC45_RS08370	COG2226	methyltransferase
FORC45_RS08375	COG0799	negative regulation of ribosome biogenesis
FORC45_RS08380	COG1713	HD superfamily hydrolase involved in NAD metabolism
FORC45_RS08390	COG1534	Rna-binding protein
FORC45_RS08400	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FORC45_RS08405	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
FORC45_RS08425	COG3177	Filamentation induced by cAMP protein fic
FORC45_RS08430	COG1914	H( )-stimulated, divalent metal cation uptake system
FORC45_RS08440	COG0439	Biotin carboxylase
FORC45_RS08445	COG0511	ligase activity, forming carbon-carbon bonds
FORC45_RS08450	COG1984	allophanate hydrolase subunit 2
FORC45_RS08455	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FORC45_RS08470	COG0826	peptidase U32
FORC45_RS08475	COG0826	peptidase U32
FORC45_RS08505	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FORC45_RS08525	COG1104	cysteine desulfurase activity
FORC45_RS08530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FORC45_RS08540	COG3237	CsbD-like
FORC45_RS08545	COG1959	2 iron, 2 sulfur cluster binding
FORC45_RS08550	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FORC45_RS08555	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FORC45_RS08600	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FORC45_RS08600	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
FORC45_RS08605	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC45_RS08605	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC45_RS08610	COG1862	Preprotein translocase
FORC45_RS08650	COG2868	ribosomal protein
FORC45_RS08695	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
FORC45_RS08705	COG0285	dihydrofolate synthase activity
FORC45_RS08715	COG2818	Glycosylase
FORC45_RS08750	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FORC45_RS08785	COG4112	unkown
FORC45_RS08810	COG0833	amino acid
FORC45_RS08825	COG1484	DNA-dependent DNA replication
FORC45_RS08855	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC45_RS08855	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC45_RS08865	COG5002	protein histidine kinase activity
FORC45_RS08870	COG0745	RESPONSE REGULATOR receiver
FORC45_RS08885	COG0372	Belongs to the citrate synthase family
FORC45_RS08890	COG1113	amino acid transport
FORC45_RS08915	COG0281	malic enzyme
FORC45_RS08925	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FORC45_RS08935	COG4109	DRTGG domain
FORC45_RS08975	COG0827	DNA restriction-modification system
FORC45_RS08985	COG0730	response to heat
FORC45_RS08995	COG1104	cysteine desulfurase activity
FORC45_RS09010	COG1956	GAF domain-containing protein
FORC45_RS09030	COG0584	glycerophosphoryl diester phosphodiesterase
FORC45_RS09035	COG1764	response to oxidative stress
FORC45_RS09040	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FORC45_RS09045	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FORC45_RS09060	COG1263	PTS System
FORC45_RS09060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC45_RS09065	COG0204	Acyl-transferase
FORC45_RS09070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FORC45_RS09105	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FORC45_RS09110	COG0454	-acetyltransferase
FORC45_RS09130	COG1605	Chorismate mutase
FORC45_RS09130	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
FORC45_RS09160	COG1674	ftsk spoiiie
FORC45_RS09165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC45_RS09175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FORC45_RS09180	COG1363	Peptidase, m42
FORC45_RS09190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FORC45_RS09200	COG0510	thiamine kinase activity
FORC45_RS09220	COG1187	pseudouridine synthase activity
FORC45_RS09225	COG2244	polysaccharide biosynthetic process
FORC45_RS09230	COG2081	HI0933 family
FORC45_RS09250	COG2814	Major facilitator Superfamily
FORC45_RS09255	COG1242	4 iron, 4 sulfur cluster binding
FORC45_RS09260	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
FORC45_RS09270	COG2267	carboxylic ester hydrolase activity
FORC45_RS09305	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FORC45_RS09305	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FORC45_RS09325	COG4193	domain, Protein
FORC45_RS09325	COG3266	domain, Protein
FORC45_RS09325	COG5632	N-Acetylmuramoyl-L-alanine amidase
FORC45_RS09355	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FORC45_RS09380	COG0656	L-ascorbic acid biosynthetic process
FORC45_RS09400	COG1506	peptidase
FORC45_RS09405	COG2816	NAD+ diphosphatase activity
FORC45_RS09570	COG1131	(ABC) transporter
FORC45_RS09690	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
FORC45_RS09720	COG1131	(ABC) transporter
FORC45_RS09725	COG0537	adenosine 5'-monophosphoramidase activity
FORC45_RS09760	COG0420	3'-5' exonuclease activity
FORC45_RS09790	COG2197	response regulator
FORC45_RS09795	COG4585	Histidine kinase
FORC45_RS09795	COG2203	Gaf domain
FORC45_RS09800	COG0564	pseudouridine synthase activity
FORC45_RS09835	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FORC45_RS09840	COG1126	abc transporter atp-binding protein
FORC45_RS09845	COG0765	amino acid transport
FORC45_RS10010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FORC45_RS10015	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FORC45_RS10025	COG4129	membrane
FORC45_RS10050	COG1988	membrane-bound metal-dependent
FORC45_RS10065	COG1388	LysM domain
FORC45_RS10065	COG1134	teichoic acid transport
FORC45_RS10095	COG0535	radical SAM domain protein
FORC45_RS10100	COG1607	acyl-coa hydrolase
FORC45_RS10105	COG2309	aminopeptidase activity
FORC45_RS10125	COG1295	ribonuclease BN
FORC45_RS10250	COG4851	CamS sex pheromone cAM373 precursor
FORC45_RS10260	COG0210	DNA helicase
FORC45_RS10270	COG4496	protein, YerC YecD
FORC45_RS10310	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FORC45_RS10320	COG0077	Prephenate dehydratase
FORC45_RS10340	COG1335	isochorismatase
FORC45_RS10355	COG1012	belongs to the aldehyde dehydrogenase family
FORC45_RS10405	COG1131	(ABC) transporter
FORC45_RS10420	COG1725	Transcriptional regulator
FORC45_RS10475	COG0860	N-Acetylmuramoyl-L-alanine amidase
FORC45_RS10475	COG1388	LysM domain
FORC45_RS10500	COG1388	LysM domain
FORC45_RS10500	COG5632	N-Acetylmuramoyl-L-alanine amidase
FORC45_RS10550	COG0739	heme binding
FORC45_RS10605	COG4695	Portal protein
FORC45_RS10795	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
FORC45_RS10800	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FORC45_RS10815	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FORC45_RS10840	COG3728	DNA packaging
FORC45_RS10840	COG5484	DNA packaging
FORC45_RS10920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC45_RS10925	COG1621	beta-fructofuranosidase activity
FORC45_RS10930	COG1609	Transcriptional regulator
FORC45_RS10935	COG0004	ammonium transporteR
FORC45_RS10940	COG0425	Belongs to the sulfur carrier protein TusA family
FORC45_RS10945	COG2391	methyltransferase activity
FORC45_RS10955	COG0488	(ABC) transporter
FORC45_RS10965	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FORC45_RS10975	COG0456	acetyltransferase
FORC45_RS10980	COG1214	PFAM Peptidase M22, glycoprotease
FORC45_RS10985	COG0802	atpase or kinase
FORC45_RS11000	COG0028	Belongs to the TPP enzyme family
FORC45_RS11075	COG2183	response to ionizing radiation
FORC45_RS11080	COG1191	sigma factor activity
FORC45_RS11090	COG1366	Belongs to the anti-sigma-factor antagonist family
FORC45_RS11095	COG2208	phosphoserine phosphatase activity
FORC45_RS11130	COG3428	Bacterial PH domain
FORC45_RS11160	COG2205	protein histidine kinase activity
FORC45_RS11165	COG0745	RESPONSE REGULATOR receiver
FORC45_RS11175	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FORC45_RS11185	COG0772	Belongs to the SEDS family
FORC45_RS11200	COG1937	Protein conserved in bacteria
FORC45_RS11210	COG1418	mRNA catabolic process
FORC45_RS11260	COG0629	single-stranded DNA binding
FORC45_RS11335	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FORC45_RS11360	COG0009	L-threonylcarbamoyladenylate synthase
FORC45_RS11365	COG2890	protein-(glutamine-N5) methyltransferase activity
FORC45_RS11390	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FORC45_RS11430	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FORC45_RS11480	COG0813	purine-nucleoside phosphorylase activity
FORC45_RS11485	COG0783	Belongs to the Dps family
FORC45_RS11505	COG1482	cell wall glycoprotein biosynthetic process
FORC45_RS11510	COG0702	epimerase
FORC45_RS11515	COG0640	Transcriptional regulator
FORC45_RS11550	COG0561	phosphatase activity
FORC45_RS11555	COG1119	ATPase activity
FORC45_RS11570	COG3711	transcriptional antiterminator
FORC45_RS11600	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
FORC45_RS11660	COG0489	protein tyrosine kinase activity
FORC45_RS11665	COG2814	Major facilitator Superfamily
FORC45_RS11680	COG1272	protein, Hemolysin III
FORC45_RS11690	COG1988	membrane-bound metal-dependent
FORC45_RS11700	COG3314	Sporulation integral membrane protein YlbJ
FORC45_RS11705	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC45_RS11710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC45_RS11715	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FORC45_RS11725	COG3457	Alanine racemase
FORC45_RS11730	COG4264	IucA IucC family
FORC45_RS11735	COG2814	Major facilitator Superfamily
FORC45_RS11760	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FORC45_RS11770	COG2130	NADP-dependent
FORC45_RS11835	COG0656	L-ascorbic acid biosynthetic process
FORC45_RS11840	COG0789	Transcriptional regulator
FORC45_RS11850	COG5492	domain, Protein
FORC45_RS11860	COG3527	Alpha-acetolactate decarboxylase
FORC45_RS11865	COG0028	Belongs to the TPP enzyme family
FORC45_RS11940	COG0201	protein transport
FORC45_RS12055	COG2252	PERMEase
FORC45_RS12100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC45_RS12170	COG1763	Mo-molybdopterin cofactor biosynthetic process
FORC45_RS12190	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FORC45_RS12195	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FORC45_RS12200	COG4149	molybdate abc transporter
FORC45_RS12205	COG0725	ABC transporter, periplasmic molybdate-binding protein
FORC45_RS12220	COG1268	BioY protein
FORC45_RS12235	COG1960	acyl-CoA dehydrogenase activity
FORC45_RS12240	COG4413	Urea transporter
FORC45_RS12315	COG1757	Na H antiporter
FORC45_RS12330	COG3942	CHAP domain
FORC45_RS12410	COG1113	amino acid transport
FORC45_RS12430	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FORC45_RS12435	COG0385	Bile acid
FORC45_RS12445	COG1263	PTS System
FORC45_RS12445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC45_RS12450	COG1737	Transcriptional regulator
FORC45_RS12470	COG1028	Short-chain dehydrogenase reductase Sdr
FORC45_RS12475	COG1473	amidohydrolase
FORC45_RS12490	COG0583	DNA-binding transcription factor activity
FORC45_RS12510	COG2258	MOSC domain
FORC45_RS12530	COG1668	transmembrane transport
FORC45_RS12535	COG4152	abc transporter atp-binding protein
FORC45_RS12540	COG3152	Membrane
FORC45_RS12555	COG0786	glutamate:sodium symporter activity
FORC45_RS12565	COG0598	Magnesium transport protein CorA
FORC45_RS12580	COG0657	acetylesterase activity
FORC45_RS12590	COG2814	Major facilitator Superfamily
FORC45_RS12595	COG1566	PFAM secretion protein HlyD family protein
FORC45_RS12605	COG2814	Major facilitator Superfamily
FORC45_RS12680	COG1620	l-lactate permease
FORC45_RS12700	COG0604	alcohol dehydrogenase
FORC45_RS12735	COG1511	domain protein
FORC45_RS12750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC45_RS12750	COG1263	PTS System
FORC45_RS12765	COG3871	stress protein (general stress protein 26)
FORC45_RS12810	COG0789	Transcriptional regulator
FORC45_RS12830	COG2181	nitrate reductase activity
FORC45_RS12840	COG1140	nitrate reductase beta subunit
FORC45_RS12845	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
FORC45_RS12855	COG2146	nitrite reductase [NAD(P)H] activity
FORC45_RS12860	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FORC45_RS12870	COG0454	-acetyltransferase
FORC45_RS12875	COG2116	formate transmembrane transporter activity
FORC45_RS12890	COG3443	Belongs to the bacterial solute-binding protein 9 family
FORC45_RS12890	COG0803	Belongs to the bacterial solute-binding protein 9 family
FORC45_RS12925	COG1126	abc transporter atp-binding protein
FORC45_RS12930	COG0765	amino acid transport
FORC45_RS12935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC45_RS12940	COG2814	Major facilitator Superfamily
FORC45_RS12960	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FORC45_RS13010	COG0156	8-amino-7-oxononanoate synthase activity
FORC45_RS13020	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FORC45_RS13025	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FORC45_RS13040	COG1132	(ABC) transporter
FORC45_RS13045	COG2375	cellular response to nickel ion
FORC45_RS13045	COG1132	(ABC) transporter
FORC45_RS13065	COG1929	Belongs to the glycerate kinase type-1 family
FORC45_RS13075	COG2814	Major facilitator Superfamily
FORC45_RS13095	COG1113	amino acid transport
FORC45_RS13110	COG0531	amino acid
FORC45_RS13135	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FORC45_RS13145	COG1174	glycine betaine transport
FORC45_RS13155	COG1174	glycine betaine transport
FORC45_RS13185	COG0531	amino acid
FORC45_RS13190	COG2272	Belongs to the type-B carboxylesterase lipase family
FORC45_RS13195	COG2814	Major facilitator Superfamily
FORC45_RS13200	COG0390	transport system, permease component
FORC45_RS13205	COG4619	ABC transporter
FORC45_RS13210	COG1363	Peptidase, m42
FORC45_RS13230	COG4808	Protein conserved in bacteria
FORC45_RS13235	COG0069	glutamate synthase activity
FORC45_RS13250	COG1124	(ABC) transporter
FORC45_RS13255	COG0444	Belongs to the ABC transporter superfamily
FORC45_RS13260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC45_RS13295	COG1028	Short-chain dehydrogenase reductase Sdr
FORC45_RS13300	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FORC45_RS13305	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FORC45_RS13380	COG0494	nUDIX hydrolase
FORC45_RS13425	COG1846	Transcriptional regulator
FORC45_RS13460	COG1070	Carbohydrate kinase
FORC45_RS13465	COG1802	Transcriptional regulator
FORC45_RS13470	COG0789	Transcriptional regulator
FORC45_RS13475	COG2357	RelA SpoT domain protein
FORC45_RS13480	COG4876	unkown
FORC45_RS13495	COG2271	Major facilitator Superfamily
FORC45_RS13500	COG0586	Pfam SNARE associated Golgi protein
FORC45_RS13515	COG1131	(ABC) transporter
FORC45_RS13535	COG0400	carboxylic ester hydrolase activity
FORC45_RS13540	COG0346	lactoylglutathione lyase activity
FORC45_RS13545	COG1846	Transcriptional regulator
FORC45_RS13555	COG2514	catechol 2,3-dioxygenase activity
FORC45_RS13570	COG0561	phosphatase activity
FORC45_RS13575	COG1131	(ABC) transporter
FORC45_RS13585	COG3764	Sortase (surface protein transpeptidase)
FORC45_RS13610	COG1760	l-serine dehydratase
FORC45_RS13615	COG1760	l-serine dehydratase
FORC45_RS13630	COG0697	spore germination
FORC45_RS13635	COG0657	acetylesterase activity
FORC45_RS13655	COG0028	Belongs to the TPP enzyme family
FORC45_RS13670	COG0583	DNA-binding transcription factor activity
FORC45_RS13680	COG3942	CHAP domain
FORC45_RS13690	COG3425	synthase
FORC45_RS13695	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FORC45_RS13720	COG2409	Drug exporters of the RND superfamily
FORC45_RS13765	COG0436	Aminotransferase
FORC45_RS13795	COG3942	CHAP domain
FORC45_RS13800	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FORC45_RS13800	COG2755	lipolytic protein G-D-S-L family
FORC45_RS13910	COG3001	Fructosamine kinase
FORC45_RS13915	COG0167	dihydroorotate dehydrogenase activity
FORC45_RS13970	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FORC45_RS13975	COG3527	Alpha-acetolactate decarboxylase
FORC45_RS13990	COG0531	amino acid
FORC45_RS14020	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FORC45_RS14040	COG1012	belongs to the aldehyde dehydrogenase family
FORC45_RS14050	COG1510	regulation of RNA biosynthetic process
FORC45_RS14060	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FORC45_RS14085	COG2851	Citrate transporter
FORC45_RS14095	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FORC45_RS14105	COG0386	Belongs to the glutathione peroxidase family
FORC45_RS14130	COG1136	(ABC) transporter
FORC45_RS14135	COG2205	protein histidine kinase activity
FORC45_RS14140	COG0745	RESPONSE REGULATOR receiver
FORC45_RS14150	COG1785	Belongs to the alkaline phosphatase family
FORC45_RS14160	COG1846	Transcriptional regulator
FORC45_RS14205	COG1438	arginine binding
FORC45_RS14225	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC45_RS14225	COG3711	transcriptional antiterminator
FORC45_RS14230	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC45_RS14230	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC45_RS14230	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC45_RS14235	COG1482	cell wall glycoprotein biosynthetic process
FORC45_RS14245	COG1705	Flagellar rod assembly protein muramidase FlgJ
FORC45_RS14245	COG3942	CHAP domain
FORC45_RS14250	COG3433	isochorismatase activity
FORC45_RS14250	COG1535	isochorismatase
FORC45_RS14265	COG0438	transferase activity, transferring glycosyl groups
FORC45_RS14280	COG1073	alpha beta
FORC45_RS14300	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FORC45_RS14320	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FORC45_RS14375	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
FORC45_RS14410	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FORC45_RS14490	COG0471	metal ion transport
FORC45_RS14495	COG2962	Rard protein
FORC45_RS14505	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
FORC45_RS14520	COG1136	(ABC) transporter
FORC45_RS14525	COG0577	efflux transmembrane transporter activity
FORC45_RS14535	COG1278	Cold shock
FORC45_RS14555	COG1475	DNA binding