locus-tag	class	description
I5044_RS00015	COG2501	S4 domain
I5044_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I5044_RS00060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I5044_RS00070	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
I5044_RS00080	COG0305	Participates in initiation and elongation during chromosome replication
I5044_RS00110	COG4863	YycH protein
I5044_RS00120	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I5044_RS00125	COG0737	Belongs to the 5'-nucleotidase family
I5044_RS00160	COG1522	sequence-specific DNA binding
I5044_RS00165	COG0456	acetyltransferase
I5044_RS00190	COG0655	NAD(P)H dehydrogenase (quinone) activity
I5044_RS00210	COG0823	Involved in the tonB-independent uptake of proteins
I5044_RS00225	COG1473	amidohydrolase
I5044_RS00235	COG1283	sodium-dependent phosphate transmembrane transporter activity
I5044_RS00240	COG4716	Myosin-crossreactive antigen
I5044_RS00245	COG0697	spore germination
I5044_RS00260	COG1620	l-lactate permease
I5044_RS00275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5044_RS00280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5044_RS00285	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I5044_RS00295	COG2423	ornithine cyclodeaminase activity
I5044_RS00300	COG4264	IucA IucC family
I5044_RS00305	COG2814	Major facilitator Superfamily
I5044_RS00310	COG4264	IucA IucC family
I5044_RS00315	COG4264	IucA IucC family
I5044_RS00325	COG0019	diaminopimelate decarboxylase activity
I5044_RS00330	COG1475	DNA binding
I5044_RS00355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I5044_RS00360	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I5044_RS00365	COG0438	transferase activity, transferring glycosyl groups
I5044_RS00390	COG0813	purine-nucleoside phosphorylase activity
I5044_RS00395	COG2814	Major facilitator Superfamily
I5044_RS00415	COG3639	organic phosphonate transmembrane transporter activity
I5044_RS00435	COG0737	Belongs to the 5'-nucleotidase family
I5044_RS00450	COG1454	alcohol dehydrogenase
I5044_RS00450	COG1012	belongs to the aldehyde dehydrogenase family
I5044_RS00475	COG1086	Polysaccharide biosynthesis protein
I5044_RS00485	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I5044_RS00515	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I5044_RS00525	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I5044_RS00530	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I5044_RS00540	COG2832	Protein of unknown function (DUF454)
I5044_RS00575	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5044_RS00580	COG1960	acyl-CoA dehydrogenase activity
I5044_RS00600	COG3477	response to acidic pH
I5044_RS00625	COG1114	Component of the transport system for branched-chain amino acids
I5044_RS00630	COG1335	isochorismatase
I5044_RS00635	COG3961	Belongs to the TPP enzyme family
I5044_RS00665	COG1737	Transcriptional regulator
I5044_RS00690	COG0601	transmembrane transport
I5044_RS00695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5044_RS00705	COG0405	Gamma-glutamyltransferase
I5044_RS00725	COG3842	ATPase activity
I5044_RS00735	COG1175	transmembrane transport
I5044_RS00740	COG3833	ABC-type maltose transport systems, permease component
I5044_RS00745	COG0673	inositol 2-dehydrogenase activity
I5044_RS00750	COG0673	inositol 2-dehydrogenase activity
I5044_RS00760	COG1755	Isoprenylcysteine carboxyl methyltransferase
I5044_RS00815	COG0183	Belongs to the thiolase family
I5044_RS00825	COG1960	acyl-CoA dehydrogenase activity
I5044_RS00830	COG0318	PFAM AMP-dependent synthetase and ligase
I5044_RS00845	COG0747	negative chemotaxis
I5044_RS00850	COG3189	MarR family transcriptional regulator
I5044_RS00875	COG1263	PTS System
I5044_RS00875	COG2190	(PTS) system
I5044_RS00875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5044_RS00880	COG1957	nucleoside hydrolase
I5044_RS00900	COG3414	Phosphotransferase system galactitol-specific IIB component
I5044_RS00905	COG3775	system Galactitol-specific IIC component
I5044_RS00910	COG1063	alcohol dehydrogenase
I5044_RS00920	COG1063	alcohol dehydrogenase
I5044_RS00930	COG1063	alcohol dehydrogenase
I5044_RS00935	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I5044_RS00940	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I5044_RS00950	COG1063	alcohol dehydrogenase
I5044_RS00955	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I5044_RS00995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5044_RS01000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5044_RS01000	COG2190	(PTS) system
I5044_RS01000	COG1263	PTS System
I5044_RS01005	COG2723	6-phospho-beta-galactosidase activity
I5044_RS01010	COG2226	methyltransferase
I5044_RS01065	COG1131	(ABC) transporter
I5044_RS01085	COG1388	LysM domain
I5044_RS01085	COG3942	CHAP domain
I5044_RS01235	COG1114	Component of the transport system for branched-chain amino acids
I5044_RS01240	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
I5044_RS01245	COG0577	efflux transmembrane transporter activity
I5044_RS01270	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I5044_RS01275	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I5044_RS01300	COG3314	Sporulation integral membrane protein YlbJ
I5044_RS01325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5044_RS01350	COG3037	sugar-specific permease SgaT UlaA
I5044_RS01360	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5044_RS01365	COG3711	transcriptional antiterminator
I5044_RS01385	COG2271	Major facilitator Superfamily
I5044_RS01390	COG0346	lactoylglutathione lyase activity
I5044_RS01395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5044_RS01400	COG0431	NADPH-dependent FMN reductase
I5044_RS01410	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5044_RS01415	COG2822	iron ion transport
I5044_RS01425	COG0672	)-iron permease
I5044_RS01430	COG0805	protein transport
I5044_RS01435	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I5044_RS01445	COG1476	TRANSCRIPTIONal
I5044_RS01455	COG1131	(ABC) transporter
I5044_RS01490	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I5044_RS01490	COG0646	methionine synthase
I5044_RS01495	COG0626	cystathionine gamma-synthase activity
I5044_RS01500	COG0626	cystathionine gamma-synthase activity
I5044_RS01505	COG1475	DNA binding
I5044_RS01510	COG0668	transmembrane transport
I5044_RS01515	COG4481	Protein conserved in bacteria
I5044_RS01520	COG0012	GTP binding
I5044_RS01620	COG1823	symporter activity
I5044_RS01650	COG2233	PERMEase
I5044_RS01700	COG1683	Conserved Protein
I5044_RS01710	COG3759	membrane
I5044_RS01885	COG0523	cobalamin synthesis protein
I5044_RS01910	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I5044_RS01920	COG5609	conserved protein (DUF2294)
I5044_RS01935	COG1647	Serine aminopeptidase, S33
I5044_RS01940	COG0733	neurotransmitter:sodium symporter activity
I5044_RS01945	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I5044_RS01950	COG0626	cystathionine gamma-synthase activity
I5044_RS01960	COG2011	ABC-type metal ion transport system permease component
I5044_RS01965	COG1464	Belongs to the NlpA lipoprotein family
I5044_RS02000	COG0583	DNA-binding transcription factor activity
I5044_RS02005	COG0069	glutamate synthase activity
I5044_RS02005	COG0067	glutamate synthase
I5044_RS02005	COG0070	glutamate synthase
I5044_RS02010	COG0493	'glutamate synthase
I5044_RS02020	COG1263	PTS System
I5044_RS02020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5044_RS02025	COG0366	Alpha amylase catalytic
I5044_RS02030	COG2188	Transcriptional regulator
I5044_RS02050	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I5044_RS02085	COG1982	Orn Lys Arg decarboxylase major
I5044_RS02095	COG3870	Protein conserved in bacteria
I5044_RS02100	COG0470	DNA polymerase III
I5044_RS02105	COG1774	PSP1 C-terminal conserved region
I5044_RS02115	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I5044_RS02125	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I5044_RS02135	COG0084	hydrolase, TatD family'
I5044_RS02140	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I5044_RS02150	COG4466	Protein conserved in bacteria
I5044_RS02160	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I5044_RS02165	COG0251	oxidation-reduction process
I5044_RS02205	COG2244	polysaccharide biosynthetic process
I5044_RS02210	COG3956	TIGRFAM MazG family protein
I5044_RS02215	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I5044_RS02225	COG1098	S1 RNA binding domain
I5044_RS02240	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I5044_RS02265	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I5044_RS02370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5044_RS02385	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I5044_RS02395	COG3880	PFAM UvrB UvrC protein
I5044_RS02410	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I5044_RS02415	COG4956	integral membrane protein (PIN domain superfamily)
I5044_RS02435	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I5044_RS02490	COG2813	Specifically methylates the guanine in position
I5044_RS02530	COG1473	amidohydrolase
I5044_RS02560	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I5044_RS02565	COG1428	Deoxynucleoside kinase
I5044_RS02570	COG1428	Deoxynucleoside kinase
I5044_RS02580	COG0561	phosphatase activity
I5044_RS02595	COG4932	domain protein
I5044_RS02620	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I5044_RS02725	COG0095	Lipoate-protein ligase
I5044_RS02730	COG0083	homoserine kinase activity
I5044_RS02750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I5044_RS02810	COG0667	Aldo Keto reductase
I5044_RS02815	COG0655	NAD(P)H dehydrogenase (quinone) activity
I5044_RS02825	COG1078	dGTPase activity
I5044_RS02855	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I5044_RS02860	COG4139	cobalamin transport
I5044_RS02910	COG4974	Belongs to the 'phage' integrase family
I5044_RS02955	COG0803	Belongs to the bacterial solute-binding protein 9 family
I5044_RS02960	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5044_RS02965	COG1121	(ABC) transporter
I5044_RS02970	COG1321	iron dependent repressor
I5044_RS02980	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I5044_RS02990	COG1682	transport, permease protein
I5044_RS02995	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I5044_RS03005	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I5044_RS03010	COG1686	Belongs to the peptidase S11 family
I5044_RS03015	COG1132	(ABC) transporter
I5044_RS03020	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I5044_RS03030	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I5044_RS03035	COG1120	ATPase activity
I5044_RS03040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5044_RS03045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5044_RS03050	COG2376	Dihydroxyacetone kinase
I5044_RS03060	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I5044_RS03070	COG3949	Membrane
I5044_RS03090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I5044_RS03105	COG1136	(ABC) transporter
I5044_RS03110	COG0577	efflux transmembrane transporter activity
I5044_RS03115	COG1392	Phosphate transport regulator
I5044_RS03120	COG0306	phosphate transporter
I5044_RS03125	COG1388	LysM domain
I5044_RS03125	COG3942	CHAP domain
I5044_RS03135	COG4977	sequence-specific DNA binding
I5044_RS03135	COG1917	Cupin 2, conserved barrel domain protein
I5044_RS03165	COG0583	DNA-binding transcription factor activity
I5044_RS03175	COG2839	Protein conserved in bacteria
I5044_RS03205	COG1611	Belongs to the LOG family
I5044_RS03225	COG4988	ABC transporter
I5044_RS03230	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I5044_RS03240	COG0523	cobalamin synthesis protein
I5044_RS03245	COG4989	oxidoreductase activity
I5044_RS03255	COG0471	metal ion transport
I5044_RS03260	COG0415	Belongs to the DNA photolyase family
I5044_RS03290	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I5044_RS03295	COG1349	DNA-binding transcription factor activity
I5044_RS03300	COG1105	Belongs to the carbohydrate kinase PfkB family
I5044_RS03305	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5044_RS03305	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5044_RS03305	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5044_RS03310	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I5044_RS03315	COG1253	flavin adenine dinucleotide binding
I5044_RS03320	COG0656	L-ascorbic acid biosynthetic process
I5044_RS03325	COG0463	Glycosyl transferase, family 2
I5044_RS03365	COG0720	synthase
I5044_RS03375	COG0512	Glutamine amidotransferase of anthranilate synthase
I5044_RS03375	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I5044_RS03380	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I5044_RS03410	COG0488	(ABC) transporter
I5044_RS03415	COG0514	ATP-dependent DNA helicase (RecQ)
I5044_RS03420	COG0517	IMP dehydrogenase activity
I5044_RS03420	COG1125	glycine betaine transport
I5044_RS03425	COG1174	glycine betaine transport
I5044_RS03450	COG3104	oligopeptide transport
I5044_RS03470	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I5044_RS03475	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I5044_RS03485	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5044_RS03490	COG4605	iron ion homeostasis
I5044_RS03495	COG4604	ABC transporter, ATP-binding protein
I5044_RS03500	COG4607	ABC-type enterochelin transport system periplasmic component
I5044_RS03555	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I5044_RS03560	COG1739	Uncharacterized protein family UPF0029
I5044_RS03570	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I5044_RS03575	COG1040	competence protein
I5044_RS03605	COG3942	CHAP domain
I5044_RS03605	COG1388	LysM domain
I5044_RS03660	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I5044_RS03675	COG0281	malic enzyme
I5044_RS03735	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I5044_RS03740	COG1647	Serine aminopeptidase, S33
I5044_RS03745	COG0557	exoribonuclease II activity
I5044_RS03825	COG1278	Cold shock
I5044_RS03865	COG0406	alpha-ribazole phosphatase activity
I5044_RS03870	COG1279	arginine transmembrane transporter activity
I5044_RS03895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I5044_RS03900	COG1393	Belongs to the ArsC family
I5044_RS03910	COG3878	Protein conserved in bacteria
I5044_RS03915	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I5044_RS03930	COG2011	ABC-type metal ion transport system permease component
I5044_RS03935	COG1464	Belongs to the NlpA lipoprotein family
I5044_RS03950	COG0396	ATPase activity
I5044_RS03955	COG0719	Fe-S assembly protein
I5044_RS03965	COG0822	iron-sulfur transferase activity
I5044_RS03985	COG1253	flavin adenine dinucleotide binding
I5044_RS03995	COG1801	Protein of unknown function DUF72
I5044_RS04000	COG0730	response to heat
I5044_RS04015	COG4470	Protein conserved in bacteria
I5044_RS04025	COG2445	Protein of unknown function DUF86
I5044_RS04055	COG1696	Membrane protein involved in D-alanine export
I5044_RS04065	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I5044_RS04070	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I5044_RS04075	COG4837	Protein of unknown function (DUF1462)
I5044_RS04080	COG1252	NADH dehydrogenase
I5044_RS04090	COG0316	Belongs to the HesB IscA family
I5044_RS04105	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I5044_RS04110	COG2056	Na+-H+ antiporter family
I5044_RS04115	COG2050	protein possibly involved in aromatic compounds catabolism
I5044_RS04170	COG1098	S1 RNA binding domain
I5044_RS04175	COG1902	pentaerythritol trinitrate reductase activity
I5044_RS04190	COG0584	glycerophosphoryl diester phosphodiesterase
I5044_RS04210	COG0398	Pfam SNARE associated Golgi protein
I5044_RS04250	COG0561	phosphatase activity
I5044_RS04275	COG1881	PFAM PEBP family protein
I5044_RS04305	COG0601	transmembrane transport
I5044_RS04310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5044_RS04315	COG0444	Belongs to the ABC transporter superfamily
I5044_RS04320	COG4608	Belongs to the ABC transporter superfamily
I5044_RS04330	COG0747	negative chemotaxis
I5044_RS04335	COG0444	Belongs to the ABC transporter superfamily
I5044_RS04340	COG4608	Belongs to the ABC transporter superfamily
I5044_RS04345	COG0601	transmembrane transport
I5044_RS04350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5044_RS04375	COG1164	Oligoendopeptidase f
I5044_RS04390	COG2346	COG2346, Truncated hemoglobins
I5044_RS04405	COG2357	RelA SpoT domain protein
I5044_RS04415	COG0564	pseudouridine synthase activity
I5044_RS04420	COG2239	Acts as a magnesium transporter
I5044_RS04425	COG0569	domain protein
I5044_RS04425	COG0475	glutathione-regulated potassium exporter activity
I5044_RS04435	COG0628	permease
I5044_RS04440	COG1115	amino acid carrier protein
I5044_RS04485	COG0861	Integral membrane protein TerC family
I5044_RS04495	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I5044_RS04500	COG0737	Belongs to the 5'-nucleotidase family
I5044_RS04515	COG4903	ComK protein
I5044_RS04530	COG4873	Protein conserved in bacteria
I5044_RS04590	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I5044_RS04600	COG2314	TM2 domain
I5044_RS04605	COG0456	acetyltransferase
I5044_RS04610	COG1575	Belongs to the MenA family. Type 1 subfamily
I5044_RS04615	COG1169	isochorismate synthase
I5044_RS04625	COG2267	carboxylic ester hydrolase activity
I5044_RS04650	COG0436	Aminotransferase
I5044_RS04655	COG3594	Acyltransferase
I5044_RS04690	COG1316	TRANSCRIPTIONal
I5044_RS04735	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I5044_RS04750	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I5044_RS04790	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I5044_RS04795	COG4172	Belongs to the ABC transporter superfamily
I5044_RS04800	COG4721	ABC-type cobalt transport system, permease component
I5044_RS04815	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I5044_RS04835	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I5044_RS04840	COG1271	oxidase subunit
I5044_RS04845	COG1294	oxidase, subunit
I5044_RS04850	COG0569	domain protein
I5044_RS04915	COG1176	ABC-type spermidine putrescine transport system, permease component I
I5044_RS04920	COG1177	transmembrane transport
I5044_RS04925	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I5044_RS04950	COG0483	inositol monophosphate 1-phosphatase activity
I5044_RS04960	COG1217	gtp-binding protein TYPA
I5044_RS04970	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I5044_RS04980	COG0772	Belongs to the SEDS family
I5044_RS05010	COG3679	Belongs to the UPF0342 family
I5044_RS05030	COG0742	ribosomal rna small subunit methyltransferase
I5044_RS05085	COG4509	Sortase family
I5044_RS05100	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I5044_RS05130	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I5044_RS05130	COG1796	DNA polymerase
I5044_RS05155	COG2009	succinate dehydrogenase
I5044_RS05160	COG1053	succinate dehydrogenase
I5044_RS05165	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I5044_RS05270	COG1288	antiporter activity
I5044_RS05305	COG1011	Hydrolase
I5044_RS05330	COG4839	cell division protein FtsL
I5044_RS05335	COG0768	penicillin binding
I5044_RS05350	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I5044_RS05355	COG0849	cell division
I5044_RS05370	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I5044_RS05380	COG0762	integral membrane protein
I5044_RS05385	COG2302	S4 RNA-binding domain
I5044_RS05390	COG3599	regulation of cell shape
I5044_RS05400	COG2514	catechol 2,3-dioxygenase activity
I5044_RS05420	COG0564	pseudouridine synthase activity
I5044_RS05430	COG2233	PERMEase
I5044_RS05475	COG1293	RNA-binding protein homologous to eukaryotic snRNP
I5044_RS05490	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I5044_RS05495	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I5044_RS05505	COG2314	TM2 domain
I5044_RS05520	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I5044_RS05520	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I5044_RS05530	COG0631	protein serine/threonine phosphatase activity
I5044_RS05545	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I5044_RS05560	COG1302	Protein conserved in bacteria
I5044_RS05605	COG1196	nuclear chromosome segregation
I5044_RS05610	COG0552	protein localization to endoplasmic reticulum
I5044_RS05620	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I5044_RS05675	COG2348	transferase activity, transferring amino-acyl groups
I5044_RS05680	COG0758	DNA mediated transformation
I5044_RS05775	COG0195	Participates in both transcription termination and antitermination
I5044_RS05780	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I5044_RS05805	COG0196	riboflavin kinase activity
I5044_RS05830	COG2188	Transcriptional regulator
I5044_RS05835	COG0612	Peptidase, M16
I5044_RS05840	COG0612	Peptidase, M16
I5044_RS05845	COG0300	oxidoreductase activity
I5044_RS05865	COG1058	Belongs to the CinA family
I5044_RS05865	COG1546	Belongs to the CinA family
I5044_RS05890	COG1692	metallophosphoesterase
I5044_RS05895	COG0674	pyruvate-flavodoxin oxidoreductase activity
I5044_RS05895	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I5044_RS05900	COG1013	pyruvate-flavodoxin oxidoreductase activity
I5044_RS05935	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I5044_RS05940	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I5044_RS05965	COG1923	regulation of RNA biosynthetic process
I5044_RS05990	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I5044_RS05995	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
I5044_RS06000	COG0789	Transcriptional regulator
I5044_RS06130	COG1131	(ABC) transporter
I5044_RS06145	COG2197	response regulator
I5044_RS06155	COG1525	nuclease
I5044_RS06170	COG0527	aspartate kinase activity
I5044_RS06175	COG0460	homoserine dehydrogenase
I5044_RS06180	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I5044_RS06205	COG0833	amino acid
I5044_RS06230	COG2340	Cysteine-rich secretory protein family
I5044_RS06255	COG3763	UPF0154 protein
I5044_RS06265	COG4846	Membrane protein involved in cytochrome C biogenesis
I5044_RS06285	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I5044_RS06295	COG0824	Thioesterase
I5044_RS06315	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I5044_RS06320	COG1115	amino acid carrier protein
I5044_RS06335	COG0628	permease
I5044_RS06360	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I5044_RS06370	COG1363	Peptidase, m42
I5044_RS06375	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I5044_RS06380	COG0512	Glutamine amidotransferase of anthranilate synthase
I5044_RS06420	COG0561	phosphatase activity
I5044_RS06465	COG0704	Plays a role in the regulation of phosphate uptake
I5044_RS06475	COG0581	inorganic phosphate transmembrane transporter activity
I5044_RS06480	COG0573	inorganic phosphate transmembrane transporter activity
I5044_RS06495	COG0488	(ABC) transporter
I5044_RS06500	COG0527	aspartate kinase activity
I5044_RS06505	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I5044_RS06575	COG4548	von Willebrand factor, type A
I5044_RS06580	COG0714	Associated with various cellular activities
I5044_RS06620	COG0671	phosphoesterase, PA-phosphatase related
I5044_RS06700	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I5044_RS06720	COG0531	amino acid
I5044_RS06735	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I5044_RS06740	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I5044_RS06755	COG0116	Belongs to the methyltransferase superfamily
I5044_RS06790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I5044_RS06790	COG4499	WXG100 protein secretion system (Wss), protein YukC
I5044_RS06800	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I5044_RS06805	COG3935	DnaD domain protein
I5044_RS06830	COG0438	transferase activity, transferring glycosyl groups
I5044_RS06835	COG1694	Mazg nucleotide pyrophosphohydrolase
I5044_RS06840	COG2738	Putative neutral zinc metallopeptidase
I5044_RS06845	COG4347	Protein of unknown function (DUF1405)
I5044_RS06880	COG0142	geranyltranstransferase activity
I5044_RS06935	COG0492	ferredoxin-NADP+ reductase activity
I5044_RS06950	COG0514	ATP-dependent DNA helicase (RecQ)
I5044_RS06960	COG1141	Ferredoxin
I5044_RS06990	COG5002	protein histidine kinase activity
I5044_RS06995	COG0745	RESPONSE REGULATOR receiver
I5044_RS07000	COG1187	pseudouridine synthase activity
I5044_RS07025	COG0735	belongs to the Fur family
I5044_RS07030	COG0494	nUDIX hydrolase
I5044_RS07035	COG0667	Aldo Keto reductase
I5044_RS07045	COG4221	oxidoreductase activity
I5044_RS07060	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I5044_RS07070	COG0366	Alpha amylase catalytic
I5044_RS07075	COG1609	Transcriptional regulator
I5044_RS07095	COG2195	Cleaves the N-terminal amino acid of tripeptides
I5044_RS07105	COG4129	membrane
I5044_RS07115	COG0508	dehydrogenase complex catalyzes the overall conversion of
I5044_RS07120	COG0022	dehydrogenase e1 component
I5044_RS07125	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I5044_RS07130	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I5044_RS07135	COG0497	DNA recombination
I5044_RS07165	COG1302	Protein conserved in bacteria
I5044_RS07170	COG0439	Biotin carboxylase
I5044_RS07175	COG0511	ligase activity, forming carbon-carbon bonds
I5044_RS07185	COG0006	proline dipeptidase activity
I5044_RS07200	COG0095	Lipoate-protein ligase
I5044_RS07205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I5044_RS07250	COG4537	Required for transformation and DNA binding
I5044_RS07255	COG1459	type II secretion system
I5044_RS07260	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I5044_RS07265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5044_RS07270	COG0011	TIGRFAM Protein of
I5044_RS07275	COG1940	carbohydrate kinase activity
I5044_RS07280	COG4483	Protein conserved in bacteria
I5044_RS07290	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I5044_RS07300	COG0768	penicillin binding
I5044_RS07315	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5044_RS07320	COG1121	(ABC) transporter
I5044_RS07330	COG0513	Belongs to the DEAD box helicase family
I5044_RS07340	COG2384	SAM-dependent methyltransferase
I5044_RS07360	COG0517	IMP dehydrogenase activity
I5044_RS07380	COG0295	cytidine deaminase activity
I5044_RS07385	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I5044_RS07395	COG1702	phosphate starvation-inducible protein PhoH
I5044_RS07410	COG1030	water channel activity
I5044_RS07420	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I5044_RS07425	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I5044_RS07455	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I5044_RS07470	COG1466	dna polymerase III delta subunit
I5044_RS07480	COG2131	deaminase
I5044_RS07485	COG2183	response to ionizing radiation
I5044_RS07490	COG2226	methyltransferase
I5044_RS07495	COG0799	negative regulation of ribosome biogenesis
I5044_RS07500	COG1713	HD superfamily hydrolase involved in NAD metabolism
I5044_RS07510	COG1534	Rna-binding protein
I5044_RS07520	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I5044_RS07525	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I5044_RS07545	COG3177	Filamentation induced by cAMP protein fic
I5044_RS07550	COG1914	H( )-stimulated, divalent metal cation uptake system
I5044_RS07560	COG0439	Biotin carboxylase
I5044_RS07565	COG0511	ligase activity, forming carbon-carbon bonds
I5044_RS07570	COG1984	allophanate hydrolase subunit 2
I5044_RS07575	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I5044_RS07590	COG0826	peptidase U32
I5044_RS07595	COG0826	peptidase U32
I5044_RS07625	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I5044_RS07640	COG1104	cysteine desulfurase activity
I5044_RS07645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5044_RS07655	COG3237	CsbD-like
I5044_RS07660	COG1959	2 iron, 2 sulfur cluster binding
I5044_RS07665	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I5044_RS07670	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I5044_RS07715	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I5044_RS07715	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I5044_RS07720	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I5044_RS07720	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I5044_RS07725	COG1862	Preprotein translocase
I5044_RS07765	COG2868	ribosomal protein
I5044_RS07810	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I5044_RS07815	COG0285	dihydrofolate synthase activity
I5044_RS07825	COG2818	Glycosylase
I5044_RS07860	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I5044_RS07895	COG4112	unkown
I5044_RS07915	COG0833	amino acid
I5044_RS07930	COG1484	DNA-dependent DNA replication
I5044_RS07960	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I5044_RS07960	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I5044_RS07970	COG5002	protein histidine kinase activity
I5044_RS07975	COG0745	RESPONSE REGULATOR receiver
I5044_RS07985	COG0372	Belongs to the citrate synthase family
I5044_RS07990	COG1113	amino acid transport
I5044_RS08015	COG0281	malic enzyme
I5044_RS08025	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I5044_RS08030	COG4109	DRTGG domain
I5044_RS08070	COG0827	DNA restriction-modification system
I5044_RS08080	COG0730	response to heat
I5044_RS08090	COG1104	cysteine desulfurase activity
I5044_RS08100	COG1956	GAF domain-containing protein
I5044_RS08110	COG0584	glycerophosphoryl diester phosphodiesterase
I5044_RS08115	COG1764	response to oxidative stress
I5044_RS08120	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I5044_RS08125	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I5044_RS08140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5044_RS08140	COG1263	PTS System
I5044_RS08145	COG0204	Acyl-transferase
I5044_RS08150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I5044_RS08185	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I5044_RS08190	COG0454	-acetyltransferase
I5044_RS08210	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I5044_RS08210	COG1605	Chorismate mutase
I5044_RS08235	COG1674	ftsk spoiiie
I5044_RS08240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I5044_RS08250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I5044_RS08255	COG1363	Peptidase, m42
I5044_RS08265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5044_RS08275	COG0510	thiamine kinase activity
I5044_RS08295	COG1187	pseudouridine synthase activity
I5044_RS08300	COG2244	polysaccharide biosynthetic process
I5044_RS08305	COG2081	HI0933 family
I5044_RS08325	COG2814	Major facilitator Superfamily
I5044_RS08330	COG1242	4 iron, 4 sulfur cluster binding
I5044_RS08335	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I5044_RS08345	COG2267	carboxylic ester hydrolase activity
I5044_RS08375	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I5044_RS08375	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I5044_RS08400	COG5632	N-Acetylmuramoyl-L-alanine amidase
I5044_RS08400	COG4193	domain, Protein
I5044_RS08400	COG3266	domain, Protein
I5044_RS08435	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I5044_RS08455	COG0656	L-ascorbic acid biosynthetic process
I5044_RS08475	COG1506	peptidase
I5044_RS08480	COG2816	NAD+ diphosphatase activity
I5044_RS08575	COG5492	domain, Protein
I5044_RS08690	COG5632	N-Acetylmuramoyl-L-alanine amidase
I5044_RS08690	COG1388	LysM domain
I5044_RS08790	COG1783	phage Terminase large subunit
I5044_RS08885	COG1484	DNA-dependent DNA replication
I5044_RS08960	COG0582	viral genome integration into host DNA
I5044_RS09010	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I5044_RS09040	COG1131	(ABC) transporter
I5044_RS09045	COG0537	adenosine 5'-monophosphoramidase activity
I5044_RS09075	COG0420	3'-5' exonuclease activity
I5044_RS09095	COG2197	response regulator
I5044_RS09100	COG4585	Histidine kinase
I5044_RS09100	COG2203	Gaf domain
I5044_RS09105	COG0564	pseudouridine synthase activity
I5044_RS09135	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I5044_RS09140	COG1126	abc transporter atp-binding protein
I5044_RS09145	COG0765	amino acid transport
I5044_RS09315	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I5044_RS09320	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I5044_RS09330	COG4129	membrane
I5044_RS09350	COG1988	membrane-bound metal-dependent
I5044_RS09360	COG1388	LysM domain
I5044_RS09360	COG1134	teichoic acid transport
I5044_RS09390	COG0535	radical SAM domain protein
I5044_RS09395	COG1607	acyl-coa hydrolase
I5044_RS09400	COG2309	aminopeptidase activity
I5044_RS09420	COG1295	ribonuclease BN
I5044_RS09535	COG4851	CamS sex pheromone cAM373 precursor
I5044_RS09555	COG4496	protein, YerC YecD
I5044_RS09590	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I5044_RS09600	COG0077	Prephenate dehydratase
I5044_RS09610	COG0471	metal ion transport
I5044_RS09620	COG1335	isochorismatase
I5044_RS09635	COG1012	belongs to the aldehyde dehydrogenase family
I5044_RS09690	COG1131	(ABC) transporter
I5044_RS09705	COG1725	Transcriptional regulator
I5044_RS09755	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I5044_RS09820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5044_RS09825	COG1621	beta-fructofuranosidase activity
I5044_RS09830	COG1609	Transcriptional regulator
I5044_RS09835	COG0004	ammonium transporteR
I5044_RS09840	COG0425	Belongs to the sulfur carrier protein TusA family
I5044_RS09845	COG2391	methyltransferase activity
I5044_RS09855	COG0488	(ABC) transporter
I5044_RS09865	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I5044_RS09875	COG0456	acetyltransferase
I5044_RS09880	COG1214	PFAM Peptidase M22, glycoprotease
I5044_RS09885	COG0802	atpase or kinase
I5044_RS09900	COG0028	Belongs to the TPP enzyme family
I5044_RS09970	COG2183	response to ionizing radiation
I5044_RS09975	COG1191	sigma factor activity
I5044_RS09985	COG1366	Belongs to the anti-sigma-factor antagonist family
I5044_RS09990	COG2208	phosphoserine phosphatase activity
I5044_RS10020	COG3428	Bacterial PH domain
I5044_RS10050	COG2205	protein histidine kinase activity
I5044_RS10055	COG0745	RESPONSE REGULATOR receiver
I5044_RS10065	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I5044_RS10075	COG0772	Belongs to the SEDS family
I5044_RS10090	COG1937	Protein conserved in bacteria
I5044_RS10100	COG1418	mRNA catabolic process
I5044_RS10135	COG0629	single-stranded DNA binding
I5044_RS10210	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I5044_RS10235	COG0009	L-threonylcarbamoyladenylate synthase
I5044_RS10240	COG2890	protein-(glutamine-N5) methyltransferase activity
I5044_RS10260	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I5044_RS10300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5044_RS10345	COG0813	purine-nucleoside phosphorylase activity
I5044_RS10350	COG0783	Belongs to the Dps family
I5044_RS10370	COG1482	cell wall glycoprotein biosynthetic process
I5044_RS10375	COG0702	epimerase
I5044_RS10380	COG0640	Transcriptional regulator
I5044_RS10415	COG0561	phosphatase activity
I5044_RS10420	COG1119	ATPase activity
I5044_RS10435	COG3711	transcriptional antiterminator
I5044_RS10465	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I5044_RS10525	COG0489	protein tyrosine kinase activity
I5044_RS10530	COG2814	Major facilitator Superfamily
I5044_RS10545	COG1272	protein, Hemolysin III
I5044_RS10555	COG1988	membrane-bound metal-dependent
I5044_RS10565	COG3314	Sporulation integral membrane protein YlbJ
I5044_RS10570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5044_RS10575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5044_RS10580	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I5044_RS10590	COG3457	Alanine racemase
I5044_RS10595	COG4264	IucA IucC family
I5044_RS10600	COG2814	Major facilitator Superfamily
I5044_RS10625	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I5044_RS10635	COG2130	NADP-dependent
I5044_RS10700	COG0656	L-ascorbic acid biosynthetic process
I5044_RS10705	COG0789	Transcriptional regulator
I5044_RS10715	COG5492	domain, Protein
I5044_RS10720	COG2378	regulation of single-species biofilm formation
I5044_RS10725	COG0693	protein deglycase activity
I5044_RS10735	COG3527	Alpha-acetolactate decarboxylase
I5044_RS10740	COG0028	Belongs to the TPP enzyme family
I5044_RS10820	COG0201	protein transport
I5044_RS10935	COG2252	PERMEase
I5044_RS10980	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5044_RS11040	COG1763	Mo-molybdopterin cofactor biosynthetic process
I5044_RS11060	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I5044_RS11065	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I5044_RS11070	COG4149	molybdate abc transporter
I5044_RS11075	COG0725	ABC transporter, periplasmic molybdate-binding protein
I5044_RS11090	COG1268	BioY protein
I5044_RS11105	COG1960	acyl-CoA dehydrogenase activity
I5044_RS11110	COG4413	Urea transporter
I5044_RS11180	COG1757	Na H antiporter
I5044_RS11195	COG3942	CHAP domain
I5044_RS11270	COG1113	amino acid transport
I5044_RS11290	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5044_RS11295	COG0385	Bile acid
I5044_RS11305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5044_RS11305	COG1263	PTS System
I5044_RS11310	COG1737	Transcriptional regulator
I5044_RS11330	COG1028	Short-chain dehydrogenase reductase Sdr
I5044_RS11335	COG1473	amidohydrolase
I5044_RS11350	COG0583	DNA-binding transcription factor activity
I5044_RS11370	COG2258	MOSC domain
I5044_RS11390	COG1668	transmembrane transport
I5044_RS11400	COG3152	Membrane
I5044_RS11410	COG0786	glutamate:sodium symporter activity
I5044_RS11420	COG0598	Magnesium transport protein CorA
I5044_RS11435	COG0657	acetylesterase activity
I5044_RS11445	COG2814	Major facilitator Superfamily
I5044_RS11450	COG1566	PFAM secretion protein HlyD family protein
I5044_RS11460	COG2814	Major facilitator Superfamily
I5044_RS11520	COG1131	(ABC) transporter
I5044_RS11535	COG1620	l-lactate permease
I5044_RS11555	COG0604	alcohol dehydrogenase
I5044_RS11580	COG1511	domain protein
I5044_RS11595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5044_RS11595	COG1263	PTS System
I5044_RS11610	COG3871	stress protein (general stress protein 26)
I5044_RS11655	COG0789	Transcriptional regulator
I5044_RS11675	COG2181	nitrate reductase activity
I5044_RS11685	COG1140	nitrate reductase beta subunit
I5044_RS11690	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I5044_RS11700	COG2146	nitrite reductase [NAD(P)H] activity
I5044_RS11705	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I5044_RS11715	COG0454	-acetyltransferase
I5044_RS11720	COG2116	formate transmembrane transporter activity
I5044_RS11735	COG3443	Belongs to the bacterial solute-binding protein 9 family
I5044_RS11735	COG0803	Belongs to the bacterial solute-binding protein 9 family
I5044_RS11770	COG1126	abc transporter atp-binding protein
I5044_RS11775	COG0765	amino acid transport
I5044_RS11780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5044_RS11785	COG2814	Major facilitator Superfamily
I5044_RS11800	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I5044_RS11840	COG0156	8-amino-7-oxononanoate synthase activity
I5044_RS11850	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I5044_RS11855	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I5044_RS11865	COG1132	(ABC) transporter
I5044_RS11870	COG2375	cellular response to nickel ion
I5044_RS11870	COG1132	(ABC) transporter
I5044_RS11885	COG1929	Belongs to the glycerate kinase type-1 family
I5044_RS11895	COG2814	Major facilitator Superfamily
I5044_RS11915	COG1113	amino acid transport
I5044_RS11925	COG0531	amino acid
I5044_RS11940	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I5044_RS11950	COG1174	glycine betaine transport
I5044_RS11960	COG1174	glycine betaine transport
I5044_RS11980	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
I5044_RS11985	COG0531	amino acid
I5044_RS11990	COG2272	Belongs to the type-B carboxylesterase lipase family
I5044_RS11995	COG2814	Major facilitator Superfamily
I5044_RS12000	COG0390	transport system, permease component
I5044_RS12005	COG4619	ABC transporter
I5044_RS12010	COG1363	Peptidase, m42
I5044_RS12015	COG4808	Protein conserved in bacteria
I5044_RS12020	COG0069	glutamate synthase activity
I5044_RS12035	COG1124	(ABC) transporter
I5044_RS12045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5044_RS12050	COG0601	transmembrane transport
I5044_RS12055	COG0747	negative chemotaxis
I5044_RS12075	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I5044_RS12080	COG1028	Short-chain dehydrogenase reductase Sdr
I5044_RS12085	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I5044_RS12090	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5044_RS12170	COG0494	nUDIX hydrolase
I5044_RS12200	COG3583	domain protein
I5044_RS12210	COG1846	Transcriptional regulator
I5044_RS12240	COG1070	Carbohydrate kinase
I5044_RS12245	COG1802	Transcriptional regulator
I5044_RS12250	COG0789	Transcriptional regulator
I5044_RS12255	COG2357	RelA SpoT domain protein
I5044_RS12260	COG4876	unkown
I5044_RS12270	COG2271	Major facilitator Superfamily
I5044_RS12275	COG0586	Pfam SNARE associated Golgi protein
I5044_RS12285	COG1131	(ABC) transporter
I5044_RS12300	COG3949	Membrane
I5044_RS12305	COG0400	carboxylic ester hydrolase activity
I5044_RS12310	COG0346	lactoylglutathione lyase activity
I5044_RS12315	COG1846	Transcriptional regulator
I5044_RS12325	COG2514	catechol 2,3-dioxygenase activity
I5044_RS12345	COG0561	phosphatase activity
I5044_RS12350	COG3764	Sortase (surface protein transpeptidase)
I5044_RS12370	COG1760	l-serine dehydratase
I5044_RS12375	COG1760	l-serine dehydratase
I5044_RS12390	COG0697	spore germination
I5044_RS12395	COG0657	acetylesterase activity
I5044_RS12420	COG0028	Belongs to the TPP enzyme family
I5044_RS12435	COG0583	DNA-binding transcription factor activity
I5044_RS12445	COG3942	CHAP domain
I5044_RS12455	COG3425	synthase
I5044_RS12460	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I5044_RS12485	COG2409	Drug exporters of the RND superfamily
I5044_RS12530	COG0436	Aminotransferase
I5044_RS12635	COG0596	Alpha beta hydrolase
I5044_RS12670	COG3001	Fructosamine kinase
I5044_RS12675	COG0167	dihydroorotate dehydrogenase activity
I5044_RS12725	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I5044_RS12730	COG3527	Alpha-acetolactate decarboxylase
I5044_RS12740	COG0531	amino acid
I5044_RS12770	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I5044_RS12790	COG1012	belongs to the aldehyde dehydrogenase family
I5044_RS12800	COG1510	regulation of RNA biosynthetic process
I5044_RS12810	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I5044_RS12835	COG2851	Citrate transporter
I5044_RS12845	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I5044_RS12855	COG0386	Belongs to the glutathione peroxidase family
I5044_RS12875	COG1136	(ABC) transporter
I5044_RS12880	COG2205	protein histidine kinase activity
I5044_RS12885	COG0745	RESPONSE REGULATOR receiver
I5044_RS12905	COG1846	Transcriptional regulator
I5044_RS12950	COG1438	arginine binding
I5044_RS12970	COG3711	transcriptional antiterminator
I5044_RS12970	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5044_RS12975	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5044_RS12975	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5044_RS12975	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5044_RS12980	COG1482	cell wall glycoprotein biosynthetic process
I5044_RS12990	COG1705	Flagellar rod assembly protein muramidase FlgJ
I5044_RS12990	COG3942	CHAP domain
I5044_RS12995	COG3433	isochorismatase activity
I5044_RS12995	COG1535	isochorismatase
I5044_RS13010	COG0438	transferase activity, transferring glycosyl groups
I5044_RS13025	COG1073	alpha beta
I5044_RS13075	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I5044_RS13165	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I5044_RS13230	COG0471	metal ion transport
I5044_RS13235	COG2962	Rard protein
I5044_RS13245	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
I5044_RS13265	COG1136	(ABC) transporter
I5044_RS13270	COG0577	efflux transmembrane transporter activity
I5044_RS13305	COG1278	Cold shock
I5044_RS13325	COG1475	DNA binding