locus-tag	class	description
B7474_RS00030	COG1288	antiporter activity
B7474_RS00065	COG1011	Hydrolase
B7474_RS00090	COG4839	cell division protein FtsL
B7474_RS00095	COG0768	penicillin binding
B7474_RS00110	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B7474_RS00115	COG0849	cell division
B7474_RS00130	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B7474_RS00140	COG0762	integral membrane protein
B7474_RS00145	COG2302	S4 RNA-binding domain
B7474_RS00150	COG3599	regulation of cell shape
B7474_RS00160	COG2514	catechol 2,3-dioxygenase activity
B7474_RS00180	COG0564	pseudouridine synthase activity
B7474_RS00190	COG2233	PERMEase
B7474_RS00235	COG1293	RNA-binding protein homologous to eukaryotic snRNP
B7474_RS00250	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B7474_RS00255	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B7474_RS00265	COG2314	TM2 domain
B7474_RS00280	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B7474_RS00280	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B7474_RS00290	COG0631	protein serine/threonine phosphatase activity
B7474_RS00305	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B7474_RS00320	COG1302	Protein conserved in bacteria
B7474_RS00370	COG1196	nuclear chromosome segregation
B7474_RS00375	COG0552	protein localization to endoplasmic reticulum
B7474_RS00385	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B7474_RS00435	COG0758	DNA mediated transformation
B7474_RS00535	COG0195	Participates in both transcription termination and antitermination
B7474_RS00540	COG2740	Nucleic-acid-binding protein implicated in transcription termination
B7474_RS00565	COG0196	riboflavin kinase activity
B7474_RS00595	COG2188	Transcriptional regulator
B7474_RS00600	COG0612	Peptidase, M16
B7474_RS00605	COG0612	Peptidase, M16
B7474_RS00610	COG0300	oxidoreductase activity
B7474_RS00630	COG1058	Belongs to the CinA family
B7474_RS00630	COG1546	Belongs to the CinA family
B7474_RS00650	COG1692	metallophosphoesterase
B7474_RS00655	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
B7474_RS00655	COG0674	pyruvate-flavodoxin oxidoreductase activity
B7474_RS00660	COG1013	pyruvate-flavodoxin oxidoreductase activity
B7474_RS00695	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
B7474_RS00700	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B7474_RS00725	COG1923	regulation of RNA biosynthetic process
B7474_RS00735	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B7474_RS00740	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
B7474_RS00745	COG0789	Transcriptional regulator
B7474_RS00870	COG1783	phage Terminase large subunit
B7474_RS00970	COG4824	toxin secretion phage lysis holin
B7474_RS01025	COG1131	(ABC) transporter
B7474_RS01040	COG2197	response regulator
B7474_RS01050	COG1525	nuclease
B7474_RS01065	COG0527	aspartate kinase activity
B7474_RS01070	COG0460	homoserine dehydrogenase
B7474_RS01075	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B7474_RS01100	COG0833	amino acid
B7474_RS01130	COG2340	Cysteine-rich secretory protein family
B7474_RS01155	COG3763	UPF0154 protein
B7474_RS01165	COG4846	Membrane protein involved in cytochrome C biogenesis
B7474_RS01185	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B7474_RS01200	COG0824	Thioesterase
B7474_RS01240	COG1115	amino acid carrier protein
B7474_RS01255	COG0628	permease
B7474_RS01280	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B7474_RS01290	COG1363	Peptidase, m42
B7474_RS01295	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B7474_RS01300	COG0512	Glutamine amidotransferase of anthranilate synthase
B7474_RS01345	COG0561	phosphatase activity
B7474_RS01390	COG0704	Plays a role in the regulation of phosphate uptake
B7474_RS01400	COG0581	inorganic phosphate transmembrane transporter activity
B7474_RS01405	COG0573	inorganic phosphate transmembrane transporter activity
B7474_RS01425	COG0488	(ABC) transporter
B7474_RS01435	COG0527	aspartate kinase activity
B7474_RS01440	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B7474_RS01515	COG4548	von Willebrand factor, type A
B7474_RS01520	COG0714	Associated with various cellular activities
B7474_RS01565	COG0671	phosphoesterase, PA-phosphatase related
B7474_RS01640	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
B7474_RS01665	COG0531	amino acid
B7474_RS01680	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B7474_RS01685	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
B7474_RS01700	COG0116	Belongs to the methyltransferase superfamily
B7474_RS01740	COG4499	WXG100 protein secretion system (Wss), protein YukC
B7474_RS01740	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B7474_RS01750	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B7474_RS01755	COG3935	DnaD domain protein
B7474_RS01780	COG0438	transferase activity, transferring glycosyl groups
B7474_RS01785	COG1694	Mazg nucleotide pyrophosphohydrolase
B7474_RS01790	COG2738	Putative neutral zinc metallopeptidase
B7474_RS01795	COG4347	Protein of unknown function (DUF1405)
B7474_RS01835	COG0142	geranyltranstransferase activity
B7474_RS01900	COG0492	ferredoxin-NADP+ reductase activity
B7474_RS01915	COG0514	ATP-dependent DNA helicase (RecQ)
B7474_RS01925	COG1141	Ferredoxin
B7474_RS01955	COG0745	RESPONSE REGULATOR receiver
B7474_RS01960	COG1187	pseudouridine synthase activity
B7474_RS01985	COG0735	belongs to the Fur family
B7474_RS01990	COG0494	nUDIX hydrolase
B7474_RS01995	COG0667	Aldo Keto reductase
B7474_RS02005	COG4221	oxidoreductase activity
B7474_RS02020	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B7474_RS02030	COG0366	Alpha amylase catalytic
B7474_RS02035	COG1609	Transcriptional regulator
B7474_RS02065	COG2195	Cleaves the N-terminal amino acid of tripeptides
B7474_RS02075	COG4129	membrane
B7474_RS02085	COG0508	dehydrogenase complex catalyzes the overall conversion of
B7474_RS02090	COG0022	dehydrogenase e1 component
B7474_RS02095	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B7474_RS02100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B7474_RS02105	COG0497	DNA recombination
B7474_RS02135	COG1302	Protein conserved in bacteria
B7474_RS02140	COG0439	Biotin carboxylase
B7474_RS02145	COG0511	ligase activity, forming carbon-carbon bonds
B7474_RS02155	COG0006	proline dipeptidase activity
B7474_RS02170	COG0095	Lipoate-protein ligase
B7474_RS02175	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B7474_RS02220	COG4537	Required for transformation and DNA binding
B7474_RS02225	COG1459	type II secretion system
B7474_RS02230	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B7474_RS02235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B7474_RS02240	COG0011	TIGRFAM Protein of
B7474_RS02245	COG1940	carbohydrate kinase activity
B7474_RS02250	COG4483	Protein conserved in bacteria
B7474_RS02260	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B7474_RS02270	COG0768	penicillin binding
B7474_RS02285	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B7474_RS02290	COG1121	(ABC) transporter
B7474_RS02300	COG0513	Belongs to the DEAD box helicase family
B7474_RS02310	COG2384	SAM-dependent methyltransferase
B7474_RS02330	COG0517	IMP dehydrogenase activity
B7474_RS02350	COG0295	cytidine deaminase activity
B7474_RS02365	COG1702	phosphate starvation-inducible protein PhoH
B7474_RS02380	COG1030	water channel activity
B7474_RS02390	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B7474_RS02395	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B7474_RS02425	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B7474_RS02445	COG1466	dna polymerase III delta subunit
B7474_RS02450	COG0658	competence protein
B7474_RS02450	COG2333	competence protein COMEC
B7474_RS02455	COG2131	deaminase
B7474_RS02465	COG2226	methyltransferase
B7474_RS02470	COG0799	negative regulation of ribosome biogenesis
B7474_RS02475	COG1713	HD superfamily hydrolase involved in NAD metabolism
B7474_RS02485	COG1534	Rna-binding protein
B7474_RS02495	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B7474_RS02500	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
B7474_RS02520	COG1914	H( )-stimulated, divalent metal cation uptake system
B7474_RS02530	COG0439	Biotin carboxylase
B7474_RS02535	COG0511	ligase activity, forming carbon-carbon bonds
B7474_RS02540	COG1984	allophanate hydrolase subunit 2
B7474_RS02545	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
B7474_RS02560	COG0826	peptidase U32
B7474_RS02565	COG0826	peptidase U32
B7474_RS02595	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B7474_RS02625	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B7474_RS02645	COG2188	Transcriptional regulator
B7474_RS02650	COG0366	Alpha amylase catalytic
B7474_RS02655	COG1263	PTS System
B7474_RS02655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B7474_RS02665	COG0493	'glutamate synthase
B7474_RS02670	COG0069	glutamate synthase activity
B7474_RS02670	COG0067	glutamate synthase
B7474_RS02670	COG0070	glutamate synthase
B7474_RS02675	COG0583	DNA-binding transcription factor activity
B7474_RS02710	COG1464	Belongs to the NlpA lipoprotein family
B7474_RS02715	COG2011	ABC-type metal ion transport system permease component
B7474_RS02725	COG0626	cystathionine gamma-synthase activity
B7474_RS02730	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B7474_RS02735	COG0733	neurotransmitter:sodium symporter activity
B7474_RS02745	COG1647	Serine aminopeptidase, S33
B7474_RS02760	COG5609	conserved protein (DUF2294)
B7474_RS02770	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B7474_RS02795	COG0523	cobalamin synthesis protein
B7474_RS02940	COG3759	membrane
B7474_RS03030	COG2233	PERMEase
B7474_RS03065	COG1823	symporter activity
B7474_RS03135	COG0582	viral genome integration into host DNA
B7474_RS03140	COG4974	Belongs to the 'phage' integrase family
B7474_RS03175	COG0012	GTP binding
B7474_RS03180	COG4481	Protein conserved in bacteria
B7474_RS03185	COG0668	transmembrane transport
B7474_RS03190	COG1475	DNA binding
B7474_RS03200	COG0626	cystathionine gamma-synthase activity
B7474_RS03205	COG0626	cystathionine gamma-synthase activity
B7474_RS03210	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B7474_RS03210	COG0646	methionine synthase
B7474_RS03240	COG1131	(ABC) transporter
B7474_RS03250	COG1476	TRANSCRIPTIONal
B7474_RS03260	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B7474_RS03265	COG0805	protein transport
B7474_RS03280	COG2822	iron ion transport
B7474_RS03285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B7474_RS03300	COG0431	NADPH-dependent FMN reductase
B7474_RS03305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B7474_RS03310	COG0346	lactoylglutathione lyase activity
B7474_RS03315	COG2271	Major facilitator Superfamily
B7474_RS03340	COG3711	transcriptional antiterminator
B7474_RS03345	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B7474_RS03355	COG3037	sugar-specific permease SgaT UlaA
B7474_RS03360	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B7474_RS03385	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B7474_RS03410	COG3314	Sporulation integral membrane protein YlbJ
B7474_RS03435	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B7474_RS03440	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B7474_RS03470	COG0577	efflux transmembrane transporter activity
B7474_RS03480	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
B7474_RS03490	COG1114	Component of the transport system for branched-chain amino acids
B7474_RS03610	COG1388	LysM domain
B7474_RS03610	COG3942	CHAP domain
B7474_RS03630	COG1131	(ABC) transporter
B7474_RS03660	COG1609	Transcriptional regulator
B7474_RS03685	COG2226	methyltransferase
B7474_RS03695	COG2723	6-phospho-beta-galactosidase activity
B7474_RS03700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B7474_RS03700	COG1263	PTS System
B7474_RS03700	COG2190	(PTS) system
B7474_RS03710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B7474_RS03745	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B7474_RS03750	COG1063	alcohol dehydrogenase
B7474_RS03760	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B7474_RS03765	COG4721	ABC-type cobalt transport system, permease component
B7474_RS03770	COG4172	Belongs to the ABC transporter superfamily
B7474_RS03775	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
B7474_RS03815	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B7474_RS03830	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B7474_RS03880	COG1316	TRANSCRIPTIONal
B7474_RS03910	COG3594	Acyltransferase
B7474_RS03915	COG0436	Aminotransferase
B7474_RS03940	COG2267	carboxylic ester hydrolase activity
B7474_RS03950	COG1169	isochorismate synthase
B7474_RS03960	COG1575	Belongs to the MenA family. Type 1 subfamily
B7474_RS03965	COG0456	acetyltransferase
B7474_RS03970	COG2314	TM2 domain
B7474_RS04035	COG4873	Protein conserved in bacteria
B7474_RS04050	COG4903	ComK protein
B7474_RS04065	COG0737	Belongs to the 5'-nucleotidase family
B7474_RS04070	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B7474_RS04080	COG0861	Integral membrane protein TerC family
B7474_RS04120	COG1115	amino acid carrier protein
B7474_RS04125	COG0628	permease
B7474_RS04135	COG0569	domain protein
B7474_RS04135	COG0475	glutathione-regulated potassium exporter activity
B7474_RS04140	COG2239	Acts as a magnesium transporter
B7474_RS04145	COG0564	pseudouridine synthase activity
B7474_RS04155	COG2357	RelA SpoT domain protein
B7474_RS04170	COG2346	COG2346, Truncated hemoglobins
B7474_RS04180	COG1164	Oligoendopeptidase f
B7474_RS04210	COG0601	transmembrane transport
B7474_RS04215	COG4608	Belongs to the ABC transporter superfamily
B7474_RS04220	COG0444	Belongs to the ABC transporter superfamily
B7474_RS04225	COG0747	negative chemotaxis
B7474_RS04230	COG4166	transmembrane transport
B7474_RS04235	COG4608	Belongs to the ABC transporter superfamily
B7474_RS04240	COG0444	Belongs to the ABC transporter superfamily
B7474_RS04245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B7474_RS04250	COG0601	transmembrane transport
B7474_RS04280	COG1881	PFAM PEBP family protein
B7474_RS04295	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B7474_RS04320	COG0561	phosphatase activity
B7474_RS04365	COG0398	Pfam SNARE associated Golgi protein
B7474_RS04385	COG0584	glycerophosphoryl diester phosphodiesterase
B7474_RS04405	COG1902	pentaerythritol trinitrate reductase activity
B7474_RS04410	COG1098	S1 RNA binding domain
B7474_RS04465	COG2050	protein possibly involved in aromatic compounds catabolism
B7474_RS04470	COG2056	Na+-H+ antiporter family
B7474_RS04475	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B7474_RS04485	COG0316	Belongs to the HesB IscA family
B7474_RS04495	COG1252	NADH dehydrogenase
B7474_RS04500	COG4837	Protein of unknown function (DUF1462)
B7474_RS04505	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
B7474_RS04510	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
B7474_RS04520	COG1696	Membrane protein involved in D-alanine export
B7474_RS04550	COG2445	Protein of unknown function DUF86
B7474_RS04560	COG4470	Protein conserved in bacteria
B7474_RS04575	COG0730	response to heat
B7474_RS04580	COG1801	Protein of unknown function DUF72
B7474_RS04600	COG1253	flavin adenine dinucleotide binding
B7474_RS04625	COG0822	iron-sulfur transferase activity
B7474_RS04635	COG0719	Fe-S assembly protein
B7474_RS04640	COG0396	ATPase activity
B7474_RS04655	COG1464	Belongs to the NlpA lipoprotein family
B7474_RS04660	COG2011	ABC-type metal ion transport system permease component
B7474_RS04675	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
B7474_RS04680	COG3878	Protein conserved in bacteria
B7474_RS04695	COG1393	Belongs to the ArsC family
B7474_RS04700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B7474_RS04725	COG1279	arginine transmembrane transporter activity
B7474_RS04730	COG0406	alpha-ribazole phosphatase activity
B7474_RS04770	COG1278	Cold shock
B7474_RS04830	COG1438	arginine binding
B7474_RS04850	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B7474_RS04850	COG3711	transcriptional antiterminator
B7474_RS04855	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B7474_RS04855	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B7474_RS04855	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B7474_RS04860	COG1482	cell wall glycoprotein biosynthetic process
B7474_RS04870	COG3942	CHAP domain
B7474_RS04870	COG1705	Flagellar rod assembly protein muramidase FlgJ
B7474_RS04875	COG3433	isochorismatase activity
B7474_RS04875	COG1535	isochorismatase
B7474_RS04890	COG0438	transferase activity, transferring glycosyl groups
B7474_RS04905	COG1073	alpha beta
B7474_RS04925	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B7474_RS04945	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B7474_RS05000	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
B7474_RS05035	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B7474_RS05120	COG0471	metal ion transport
B7474_RS05125	COG2962	Rard protein
B7474_RS05135	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
B7474_RS05150	COG1136	(ABC) transporter
B7474_RS05155	COG0577	efflux transmembrane transporter activity
B7474_RS05165	COG1278	Cold shock
B7474_RS05185	COG1475	DNA binding
B7474_RS05225	COG2501	S4 domain
B7474_RS05240	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B7474_RS05245	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B7474_RS05275	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B7474_RS05285	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
B7474_RS05295	COG0305	Participates in initiation and elongation during chromosome replication
B7474_RS05330	COG4863	YycH protein
B7474_RS05340	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B7474_RS05345	COG0737	Belongs to the 5'-nucleotidase family
B7474_RS05385	COG0730	response to heat
B7474_RS05390	COG1937	Protein conserved in bacteria
B7474_RS05395	COG2210	Belongs to the sulfur carrier protein TusA family
B7474_RS05400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B7474_RS05450	COG0823	Involved in the tonB-independent uptake of proteins
B7474_RS05500	COG1283	sodium-dependent phosphate transmembrane transporter activity
B7474_RS05505	COG4716	Myosin-crossreactive antigen
B7474_RS05515	COG1620	l-lactate permease
B7474_RS05535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B7474_RS05540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B7474_RS05545	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B7474_RS05555	COG2423	ornithine cyclodeaminase activity
B7474_RS05560	COG4264	IucA IucC family
B7474_RS05565	COG2814	Major facilitator Superfamily
B7474_RS05570	COG4264	IucA IucC family
B7474_RS05575	COG4264	IucA IucC family
B7474_RS05585	COG0019	diaminopimelate decarboxylase activity
B7474_RS05590	COG1475	DNA binding
B7474_RS05620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B7474_RS05625	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B7474_RS05630	COG0438	transferase activity, transferring glycosyl groups
B7474_RS05665	COG0813	purine-nucleoside phosphorylase activity
B7474_RS05670	COG2814	Major facilitator Superfamily
B7474_RS05680	COG0531	amino acid
B7474_RS05690	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
B7474_RS05710	COG1174	glycine betaine transport
B7474_RS05720	COG1174	glycine betaine transport
B7474_RS05730	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B7474_RS05755	COG0531	amino acid
B7474_RS05770	COG1113	amino acid transport
B7474_RS05790	COG2814	Major facilitator Superfamily
B7474_RS05800	COG1929	Belongs to the glycerate kinase type-1 family
B7474_RS05820	COG2375	cellular response to nickel ion
B7474_RS05820	COG1132	(ABC) transporter
B7474_RS05825	COG1132	(ABC) transporter
B7474_RS05840	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B7474_RS05900	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B7474_RS05925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B7474_RS05930	COG0765	amino acid transport
B7474_RS05935	COG1126	abc transporter atp-binding protein
B7474_RS05970	COG0803	Belongs to the bacterial solute-binding protein 9 family
B7474_RS05970	COG3443	Belongs to the bacterial solute-binding protein 9 family
B7474_RS05985	COG2116	formate transmembrane transporter activity
B7474_RS05990	COG0454	-acetyltransferase
B7474_RS06000	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B7474_RS06005	COG2146	nitrite reductase [NAD(P)H] activity
B7474_RS06015	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
B7474_RS06020	COG1140	nitrate reductase beta subunit
B7474_RS06030	COG2181	nitrate reductase activity
B7474_RS06050	COG0789	Transcriptional regulator
B7474_RS06090	COG3871	stress protein (general stress protein 26)
B7474_RS06105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B7474_RS06105	COG1263	PTS System
B7474_RS06120	COG1511	domain protein
B7474_RS06155	COG0604	alcohol dehydrogenase
B7474_RS06175	COG1620	l-lactate permease
B7474_RS06240	COG2814	Major facilitator Superfamily
B7474_RS06250	COG1566	PFAM secretion protein HlyD family protein
B7474_RS06255	COG2814	Major facilitator Superfamily
B7474_RS06265	COG0657	acetylesterase activity
B7474_RS06280	COG0598	Magnesium transport protein CorA
B7474_RS06290	COG0786	glutamate:sodium symporter activity
B7474_RS06305	COG3152	Membrane
B7474_RS06310	COG4152	abc transporter atp-binding protein
B7474_RS06315	COG1668	transmembrane transport
B7474_RS06335	COG2258	MOSC domain
B7474_RS06360	COG0583	DNA-binding transcription factor activity
B7474_RS06375	COG1473	amidohydrolase
B7474_RS06380	COG1028	Short-chain dehydrogenase reductase Sdr
B7474_RS06400	COG1737	Transcriptional regulator
B7474_RS06405	COG1263	PTS System
B7474_RS06405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B7474_RS06415	COG0385	Bile acid
B7474_RS06420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B7474_RS06440	COG1113	amino acid transport
B7474_RS06515	COG3942	CHAP domain
B7474_RS06530	COG1757	Na H antiporter
B7474_RS06540	COG3942	CHAP domain
B7474_RS06605	COG4413	Urea transporter
B7474_RS06610	COG1960	acyl-CoA dehydrogenase activity
B7474_RS06625	COG1268	BioY protein
B7474_RS06640	COG0725	ABC transporter, periplasmic molybdate-binding protein
B7474_RS06645	COG4149	molybdate abc transporter
B7474_RS06650	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
B7474_RS06655	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B7474_RS06675	COG1763	Mo-molybdopterin cofactor biosynthetic process
B7474_RS06720	COG1070	Carbohydrate kinase
B7474_RS06725	COG1802	Transcriptional regulator
B7474_RS06730	COG0789	Transcriptional regulator
B7474_RS06735	COG2357	RelA SpoT domain protein
B7474_RS06740	COG4876	unkown
B7474_RS06755	COG2271	Major facilitator Superfamily
B7474_RS06760	COG0586	Pfam SNARE associated Golgi protein
B7474_RS06770	COG2814	Major facilitator Superfamily
B7474_RS06775	COG1846	Transcriptional regulator
B7474_RS06790	COG1131	(ABC) transporter
B7474_RS06810	COG0400	carboxylic ester hydrolase activity
B7474_RS06815	COG0346	lactoylglutathione lyase activity
B7474_RS06820	COG1846	Transcriptional regulator
B7474_RS06845	COG0561	phosphatase activity
B7474_RS06850	COG1131	(ABC) transporter
B7474_RS06860	COG3764	Sortase (surface protein transpeptidase)
B7474_RS06885	COG1760	l-serine dehydratase
B7474_RS06890	COG1760	l-serine dehydratase
B7474_RS06905	COG0697	spore germination
B7474_RS06910	COG0657	acetylesterase activity
B7474_RS06930	COG0028	Belongs to the TPP enzyme family
B7474_RS06945	COG0583	DNA-binding transcription factor activity
B7474_RS06955	COG3942	CHAP domain
B7474_RS06965	COG3425	synthase
B7474_RS06975	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B7474_RS07000	COG2409	Drug exporters of the RND superfamily
B7474_RS07045	COG0436	Aminotransferase
B7474_RS07075	COG3942	CHAP domain
B7474_RS07080	COG2755	lipolytic protein G-D-S-L family
B7474_RS07080	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B7474_RS07150	COG0596	Alpha beta hydrolase
B7474_RS07190	COG3001	Fructosamine kinase
B7474_RS07195	COG0167	dihydroorotate dehydrogenase activity
B7474_RS07245	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B7474_RS07250	COG3527	Alpha-acetolactate decarboxylase
B7474_RS07265	COG0531	amino acid
B7474_RS07295	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B7474_RS07315	COG1012	belongs to the aldehyde dehydrogenase family
B7474_RS07325	COG1510	regulation of RNA biosynthetic process
B7474_RS07330	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B7474_RS07355	COG2851	Citrate transporter
B7474_RS07370	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B7474_RS07380	COG0386	Belongs to the glutathione peroxidase family
B7474_RS07405	COG1136	(ABC) transporter
B7474_RS07410	COG2205	protein histidine kinase activity
B7474_RS07415	COG0745	RESPONSE REGULATOR receiver
B7474_RS07425	COG1785	Belongs to the alkaline phosphatase family
B7474_RS07435	COG1846	Transcriptional regulator
B7474_RS07460	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
B7474_RS07460	COG1605	Chorismate mutase
B7474_RS07480	COG0454	-acetyltransferase
B7474_RS07485	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B7474_RS07490	COG2759	Belongs to the formate--tetrahydrofolate ligase family
B7474_RS07520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B7474_RS07525	COG0204	Acyl-transferase
B7474_RS07530	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B7474_RS07530	COG1263	PTS System
B7474_RS07545	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B7474_RS07550	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B7474_RS07555	COG1764	response to oxidative stress
B7474_RS07560	COG0584	glycerophosphoryl diester phosphodiesterase
B7474_RS07580	COG1956	GAF domain-containing protein
B7474_RS07595	COG1104	cysteine desulfurase activity
B7474_RS07605	COG0730	response to heat
B7474_RS07615	COG0827	DNA restriction-modification system
B7474_RS07660	COG4109	DRTGG domain
B7474_RS07670	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
B7474_RS07680	COG0281	malic enzyme
B7474_RS07710	COG1113	amino acid transport
B7474_RS07715	COG0372	Belongs to the citrate synthase family
B7474_RS07730	COG0745	RESPONSE REGULATOR receiver
B7474_RS07735	COG5002	protein histidine kinase activity
B7474_RS07745	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B7474_RS07745	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B7474_RS07775	COG1484	DNA-dependent DNA replication
B7474_RS07790	COG0833	amino acid
B7474_RS07815	COG4112	unkown
B7474_RS07850	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B7474_RS07885	COG2818	Glycosylase
B7474_RS07895	COG0285	dihydrofolate synthase activity
B7474_RS07905	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
B7474_RS07950	COG2868	ribosomal protein
B7474_RS07990	COG1862	Preprotein translocase
B7474_RS07995	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B7474_RS07995	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B7474_RS08000	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
B7474_RS08000	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B7474_RS08045	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B7474_RS08050	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B7474_RS08055	COG1959	2 iron, 2 sulfur cluster binding
B7474_RS08060	COG3237	CsbD-like
B7474_RS08070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B7474_RS08075	COG1104	cysteine desulfurase activity
B7474_RS08220	COG0765	amino acid transport
B7474_RS08225	COG1126	abc transporter atp-binding protein
B7474_RS08230	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B7474_RS08270	COG0564	pseudouridine synthase activity
B7474_RS08275	COG2203	Gaf domain
B7474_RS08275	COG4585	Histidine kinase
B7474_RS08280	COG2197	response regulator
B7474_RS08310	COG0420	3'-5' exonuclease activity
B7474_RS08345	COG0537	adenosine 5'-monophosphoramidase activity
B7474_RS08350	COG1131	(ABC) transporter
B7474_RS08380	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
B7474_RS08590	COG1506	peptidase
B7474_RS08610	COG0656	L-ascorbic acid biosynthetic process
B7474_RS08635	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B7474_RS08665	COG3266	domain, Protein
B7474_RS08665	COG4193	domain, Protein
B7474_RS08665	COG5632	N-Acetylmuramoyl-L-alanine amidase
B7474_RS08690	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B7474_RS08690	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B7474_RS08725	COG2267	carboxylic ester hydrolase activity
B7474_RS08735	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
B7474_RS08740	COG1242	4 iron, 4 sulfur cluster binding
B7474_RS08745	COG2814	Major facilitator Superfamily
B7474_RS08765	COG2081	HI0933 family
B7474_RS08770	COG2244	polysaccharide biosynthetic process
B7474_RS08775	COG1187	pseudouridine synthase activity
B7474_RS08795	COG0510	thiamine kinase activity
B7474_RS08805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B7474_RS08815	COG1363	Peptidase, m42
B7474_RS08820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B7474_RS08830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B7474_RS08835	COG1674	ftsk spoiiie
B7474_RS08875	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B7474_RS08890	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
B7474_RS08990	COG0095	Lipoate-protein ligase
B7474_RS08995	COG0083	homoserine kinase activity
B7474_RS09015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B7474_RS09110	COG0667	Aldo Keto reductase
B7474_RS09115	COG0655	NAD(P)H dehydrogenase (quinone) activity
B7474_RS09125	COG1078	dGTPase activity
B7474_RS09160	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B7474_RS09165	COG4139	cobalamin transport
B7474_RS09260	COG0803	Belongs to the bacterial solute-binding protein 9 family
B7474_RS09265	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B7474_RS09270	COG1121	(ABC) transporter
B7474_RS09275	COG1321	iron dependent repressor
B7474_RS09285	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
B7474_RS09295	COG1682	transport, permease protein
B7474_RS09300	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B7474_RS09310	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B7474_RS09315	COG1686	Belongs to the peptidase S11 family
B7474_RS09320	COG1132	(ABC) transporter
B7474_RS09325	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B7474_RS09335	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B7474_RS09340	COG1120	ATPase activity
B7474_RS09345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B7474_RS09350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B7474_RS09355	COG2376	Dihydroxyacetone kinase
B7474_RS09365	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
B7474_RS09375	COG3949	Membrane
B7474_RS09400	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B7474_RS09415	COG1136	(ABC) transporter
B7474_RS09420	COG0577	efflux transmembrane transporter activity
B7474_RS09425	COG1392	Phosphate transport regulator
B7474_RS09435	COG1388	LysM domain
B7474_RS09435	COG3942	CHAP domain
B7474_RS09445	COG4977	sequence-specific DNA binding
B7474_RS09445	COG1917	Cupin 2, conserved barrel domain protein
B7474_RS09475	COG0583	DNA-binding transcription factor activity
B7474_RS09505	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B7474_RS09510	COG1960	acyl-CoA dehydrogenase activity
B7474_RS09515	COG5609	conserved protein (DUF2294)
B7474_RS09565	COG1114	Component of the transport system for branched-chain amino acids
B7474_RS09570	COG1335	isochorismatase
B7474_RS09575	COG3961	Belongs to the TPP enzyme family
B7474_RS09605	COG1737	Transcriptional regulator
B7474_RS09630	COG1136	(ABC) transporter
B7474_RS09635	COG0577	efflux transmembrane transporter activity
B7474_RS09655	COG1131	(ABC) transporter
B7474_RS09670	COG0601	transmembrane transport
B7474_RS09675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B7474_RS09685	COG0405	Gamma-glutamyltransferase
B7474_RS09705	COG3842	ATPase activity
B7474_RS09720	COG3833	ABC-type maltose transport systems, permease component
B7474_RS09725	COG0673	inositol 2-dehydrogenase activity
B7474_RS09730	COG0673	inositol 2-dehydrogenase activity
B7474_RS09740	COG1755	Isoprenylcysteine carboxyl methyltransferase
B7474_RS09805	COG0183	Belongs to the thiolase family
B7474_RS09815	COG1960	acyl-CoA dehydrogenase activity
B7474_RS09820	COG0318	PFAM AMP-dependent synthetase and ligase
B7474_RS09835	COG0747	negative chemotaxis
B7474_RS09840	COG3189	MarR family transcriptional regulator
B7474_RS09875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B7474_RS09875	COG2190	(PTS) system
B7474_RS09875	COG1263	PTS System
B7474_RS09880	COG1957	nucleoside hydrolase
B7474_RS09900	COG3414	Phosphotransferase system galactitol-specific IIB component
B7474_RS09905	COG3775	system Galactitol-specific IIC component
B7474_RS09910	COG1063	alcohol dehydrogenase
B7474_RS09920	COG1063	alcohol dehydrogenase
B7474_RS09930	COG1063	alcohol dehydrogenase
B7474_RS09945	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B7474_RS09950	COG4605	iron ion homeostasis
B7474_RS09960	COG4607	ABC-type enterochelin transport system periplasmic component
B7474_RS10015	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B7474_RS10020	COG1739	Uncharacterized protein family UPF0029
B7474_RS10030	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
B7474_RS10035	COG1040	competence protein
B7474_RS10065	COG1388	LysM domain
B7474_RS10065	COG3942	CHAP domain
B7474_RS10130	COG0391	Required for morphogenesis under gluconeogenic growth conditions
B7474_RS10200	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B7474_RS10205	COG1647	Serine aminopeptidase, S33
B7474_RS10210	COG0557	exoribonuclease II activity
B7474_RS10225	COG0582	viral genome integration into host DNA
B7474_RS10310	COG1484	DNA-dependent DNA replication
B7474_RS10385	COG0756	dUTP diphosphatase activity
B7474_RS10545	COG1388	LysM domain
B7474_RS10545	COG5632	N-Acetylmuramoyl-L-alanine amidase
B7474_RS10650	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B7474_RS10700	COG2252	PERMEase
B7474_RS10815	COG0201	protein transport
B7474_RS10900	COG0542	response to heat
B7474_RS10915	COG0028	Belongs to the TPP enzyme family
B7474_RS10920	COG3527	Alpha-acetolactate decarboxylase
B7474_RS10930	COG5492	domain, Protein
B7474_RS10940	COG0789	Transcriptional regulator
B7474_RS10945	COG0656	L-ascorbic acid biosynthetic process
B7474_RS11015	COG2130	NADP-dependent
B7474_RS11025	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B7474_RS11050	COG2814	Major facilitator Superfamily
B7474_RS11055	COG4264	IucA IucC family
B7474_RS11060	COG3457	Alanine racemase
B7474_RS11075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B7474_RS11080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B7474_RS11085	COG3314	Sporulation integral membrane protein YlbJ
B7474_RS11095	COG1988	membrane-bound metal-dependent
B7474_RS11120	COG2814	Major facilitator Superfamily
B7474_RS11125	COG0489	protein tyrosine kinase activity
B7474_RS11150	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B7474_RS11170	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B7474_RS11175	COG1271	oxidase subunit
B7474_RS11180	COG1294	oxidase, subunit
B7474_RS11185	COG0569	domain protein
B7474_RS11250	COG1176	ABC-type spermidine putrescine transport system, permease component I
B7474_RS11255	COG1177	transmembrane transport
B7474_RS11260	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B7474_RS11285	COG0483	inositol monophosphate 1-phosphatase activity
B7474_RS11295	COG1217	gtp-binding protein TYPA
B7474_RS11305	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B7474_RS11315	COG0772	Belongs to the SEDS family
B7474_RS11350	COG3679	Belongs to the UPF0342 family
B7474_RS11370	COG0742	ribosomal rna small subunit methyltransferase
B7474_RS11430	COG4509	Sortase family
B7474_RS11445	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B7474_RS11480	COG1796	DNA polymerase
B7474_RS11480	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B7474_RS11505	COG2009	succinate dehydrogenase
B7474_RS11510	COG1053	succinate dehydrogenase
B7474_RS11515	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B7474_RS11595	COG1191	sigma factor activity
B7474_RS11605	COG1366	Belongs to the anti-sigma-factor antagonist family
B7474_RS11610	COG2208	phosphoserine phosphatase activity
B7474_RS11645	COG3428	Bacterial PH domain
B7474_RS11675	COG2205	protein histidine kinase activity
B7474_RS11680	COG0745	RESPONSE REGULATOR receiver
B7474_RS11690	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B7474_RS11700	COG0772	Belongs to the SEDS family
B7474_RS11715	COG1937	Protein conserved in bacteria
B7474_RS11725	COG1418	mRNA catabolic process
B7474_RS11775	COG0629	single-stranded DNA binding
B7474_RS11850	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B7474_RS11875	COG0009	L-threonylcarbamoyladenylate synthase
B7474_RS11880	COG2890	protein-(glutamine-N5) methyltransferase activity
B7474_RS11905	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B7474_RS11945	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B7474_RS12010	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B7474_RS12015	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B7474_RS12020	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
B7474_RS12065	COG1725	Transcriptional regulator
B7474_RS12080	COG1131	(ABC) transporter
B7474_RS12135	COG1012	belongs to the aldehyde dehydrogenase family
B7474_RS12150	COG1335	isochorismatase
B7474_RS12160	COG0471	metal ion transport
B7474_RS12170	COG0077	Prephenate dehydratase
B7474_RS12180	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B7474_RS12215	COG4496	protein, YerC YecD
B7474_RS12225	COG0210	DNA helicase
B7474_RS12235	COG4851	CamS sex pheromone cAM373 precursor
B7474_RS12330	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B7474_RS12335	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B7474_RS12365	COG3104	oligopeptide transport
B7474_RS12395	COG1174	glycine betaine transport
B7474_RS12400	COG0517	IMP dehydrogenase activity
B7474_RS12400	COG1125	glycine betaine transport
B7474_RS12405	COG0514	ATP-dependent DNA helicase (RecQ)
B7474_RS12410	COG0488	(ABC) transporter
B7474_RS12440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B7474_RS12445	COG0512	Glutamine amidotransferase of anthranilate synthase
B7474_RS12445	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B7474_RS12455	COG0720	synthase
B7474_RS12490	COG0463	Glycosyl transferase, family 2
B7474_RS12495	COG0656	L-ascorbic acid biosynthetic process
B7474_RS12500	COG1253	flavin adenine dinucleotide binding
B7474_RS12505	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B7474_RS12510	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B7474_RS12510	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B7474_RS12510	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B7474_RS12515	COG1105	Belongs to the carbohydrate kinase PfkB family
B7474_RS12520	COG1349	DNA-binding transcription factor activity
B7474_RS12525	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B7474_RS12555	COG0415	Belongs to the DNA photolyase family
B7474_RS12560	COG0471	metal ion transport
B7474_RS12570	COG4989	oxidoreductase activity
B7474_RS12575	COG0523	cobalamin synthesis protein
B7474_RS12585	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B7474_RS12590	COG4988	ABC transporter
B7474_RS12610	COG1611	Belongs to the LOG family
B7474_RS12640	COG2839	Protein conserved in bacteria
B7474_RS12645	COG2814	Major facilitator Superfamily
B7474_RS12650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B7474_RS12665	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B7474_RS12675	COG3880	PFAM UvrB UvrC protein
B7474_RS12690	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
B7474_RS12695	COG4956	integral membrane protein (PIN domain superfamily)
B7474_RS12720	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
B7474_RS12780	COG2813	Specifically methylates the guanine in position
B7474_RS12820	COG1473	amidohydrolase
B7474_RS12850	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
B7474_RS12855	COG1428	Deoxynucleoside kinase
B7474_RS12860	COG1428	Deoxynucleoside kinase
B7474_RS12870	COG0561	phosphatase activity
B7474_RS13030	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B7474_RS13035	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
B7474_RS13040	COG1028	Short-chain dehydrogenase reductase Sdr
B7474_RS13045	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B7474_RS13075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B7474_RS13080	COG0444	Belongs to the ABC transporter superfamily
B7474_RS13085	COG1124	(ABC) transporter
B7474_RS13100	COG0069	glutamate synthase activity
B7474_RS13105	COG4808	Protein conserved in bacteria
B7474_RS13125	COG1363	Peptidase, m42
B7474_RS13130	COG4619	ABC transporter
B7474_RS13135	COG0390	transport system, permease component
B7474_RS13140	COG2814	Major facilitator Superfamily
B7474_RS13145	COG2272	Belongs to the type-B carboxylesterase lipase family
B7474_RS13205	COG0582	viral genome integration into host DNA
B7474_RS13270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B7474_RS13275	COG1621	beta-fructofuranosidase activity
B7474_RS13280	COG1609	Transcriptional regulator
B7474_RS13285	COG0004	ammonium transporteR
B7474_RS13290	COG0425	Belongs to the sulfur carrier protein TusA family
B7474_RS13295	COG2391	methyltransferase activity
B7474_RS13305	COG0488	(ABC) transporter
B7474_RS13320	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B7474_RS13335	COG0456	acetyltransferase
B7474_RS13340	COG1214	PFAM Peptidase M22, glycoprotease
B7474_RS13345	COG0802	atpase or kinase
B7474_RS13360	COG0028	Belongs to the TPP enzyme family
B7474_RS13400	COG1982	Orn Lys Arg decarboxylase major
B7474_RS13410	COG3870	Protein conserved in bacteria
B7474_RS13420	COG1774	PSP1 C-terminal conserved region
B7474_RS13430	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
B7474_RS13440	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
B7474_RS13450	COG0084	hydrolase, TatD family'
B7474_RS13455	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
B7474_RS13465	COG4466	Protein conserved in bacteria
B7474_RS13475	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B7474_RS13480	COG0251	oxidation-reduction process
B7474_RS13525	COG2244	polysaccharide biosynthetic process
B7474_RS13530	COG3956	TIGRFAM MazG family protein
B7474_RS13535	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
B7474_RS13545	COG1098	S1 RNA binding domain
B7474_RS13560	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B7474_RS13585	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B7474_RS13680	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
B7474_RS13710	COG3711	transcriptional antiterminator
B7474_RS13725	COG1119	ATPase activity
B7474_RS13730	COG0561	phosphatase activity
B7474_RS13765	COG0640	Transcriptional regulator
B7474_RS13770	COG0702	epimerase
B7474_RS13775	COG1482	cell wall glycoprotein biosynthetic process
B7474_RS13795	COG0783	Belongs to the Dps family
B7474_RS13800	COG0813	purine-nucleoside phosphorylase activity
B7474_RS13820	COG2832	Protein of unknown function (DUF454)
B7474_RS13830	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B7474_RS13835	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
B7474_RS13845	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B7474_RS13875	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B7474_RS13885	COG1086	Polysaccharide biosynthesis protein
B7474_RS13910	COG1012	belongs to the aldehyde dehydrogenase family
B7474_RS13910	COG1454	alcohol dehydrogenase
B7474_RS13925	COG0737	Belongs to the 5'-nucleotidase family
B7474_RS13945	COG3639	organic phosphonate transmembrane transporter activity
B7474_RS13990	COG1295	ribonuclease BN
B7474_RS14010	COG2309	aminopeptidase activity
B7474_RS14015	COG1607	acyl-coa hydrolase
B7474_RS14020	COG0535	radical SAM domain protein
B7474_RS14050	COG1388	LysM domain
B7474_RS14050	COG1134	teichoic acid transport
B7474_RS14065	COG1988	membrane-bound metal-dependent
B7474_RS14090	COG4129	membrane
B7474_RS14100	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B7474_RS14105	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B7474_RS14155	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
B7474_RS14155	COG3266	domain, Protein
B7474_RS14160	COG4932	domain protein
B7474_RS14260	COG5484	DNA packaging
B7474_RS14260	COG3728	DNA packaging