locus-tag class description E3S62_RS00020 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) E3S62_RS00070 ENOG4105DR5 peptidase E3S62_RS00115 ENOG4105ZMJ n-acetylmuramoyl-l-alanine amidase E3S62_RS00125 ENOG4105ZMJ n-acetylmuramoyl-l-alanine amidase E3S62_RS00175 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family E3S62_RS00190 ENOG4105CJ1 ABC, transporter E3S62_RS00240 ENOG4105C26 Dehydrogenase E3S62_RS00265 ENOG4105C8P )-transporter E3S62_RS00275 ENOG4105CQC Prephenate dehydratase E3S62_RS00280 ENOG4107QN4 Catalyzes the production of nitric oxide (By similarity) E3S62_RS00285 ENOG4105DAP Nicotinate phosphoribosyltransferase E3S62_RS00320 ENOG4105KGF protein, YerC YecD E3S62_RS00330 ENOG4105C4R Atp-dependent dna helicase E3S62_RS00385 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) E3S62_RS00445 ENOG4105ENE Histidine kinase E3S62_RS00455 ENOG4107U9T Pfam:Ribonuclease_BN E3S62_RS00480 ENOG4108S4H thioesterase Superfamily protein E3S62_RS00490 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) E3S62_RS00565 ENOG4108UUM single-stranded DNA-binding protein E3S62_RS00585 ENOG4106CVF DNA replication protein E3S62_RS00775 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis E3S62_RS00795 ENOG4105ZMJ n-acetylmuramoyl-l-alanine amidase E3S62_RS00830 ENOG4105EY8 ABC transporter E3S62_RS00840 ENOG41067AE Membrane-bound metal-dependent hydrolase E3S62_RS00845 ENOG4105CEN a g-specific adenine glycosylase E3S62_RS00865 ENOG4107NBY Membrane E3S62_RS00875 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen E3S62_RS00880 ENOG4108M3J Dehydrogenase E3S62_RS01045 ENOG4105E5Q amino acid AbC transporter E3S62_RS01050 ENOG4105CDA abc transporter atp-binding protein E3S62_RS01055 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) E3S62_RS01085 ENOG4108YBP pseudouridine synthase E3S62_RS01090 ENOG4105BZU Histidine kinase E3S62_RS01095 ENOG4105WH1 Two component transcriptional regulator luxr family E3S62_RS01120 ENOG4107VRP DNA repair exonuclease E3S62_RS01150 ENOG4105K59 histidine triad (HIT) protein E3S62_RS01185 ENOG4105C1Q protoporphyrinogen oxidase E3S62_RS01345 ENOG4105E09 nadh pyrophosphatase E3S62_RS01370 ENOG4105CV8 reductase E3S62_RS01380 ENOG4106A8V Protein CrcB homolog E3S62_RS01390 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) E3S62_RS01425 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis E3S62_RS01445 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) E3S62_RS01450 ENOG4108R6K riboflavin synthase, subunit alpha E3S62_RS01475 ENOG4105E8V Alpha Beta Hydrolase Fold protein E3S62_RS01490 ENOG4105N5T Radical SAM Protein E3S62_RS01495 ENOG410605W Major Facilitator E3S62_RS01515 ENOG4105CBX hi0933 family E3S62_RS01545 ENOG4108V15 phosphotransferase enzyme family E3S62_RS01555 ENOG4105C8F Beta-lactamase domain protein E3S62_RS01580 ENOG4108VDD TRNA binding domain protein E3S62_RS01610 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase E3S62_RS01620 ENOG4105ETE Transcriptional regulator (LacI family E3S62_RS01625 ENOG4105DGU Histone deacetylase E3S62_RS01630 ENOG4105F1V Acetoin utilization protein E3S62_RS01670 ENOG4105C0H protease E3S62_RS01675 ENOG4105F6E Acyl-transferase E3S62_RS01695 ENOG4108JQ1 Dehydrogenase E3S62_RS01700 ENOG4105C5R Aminotransferase E3S62_RS01705 ENOG4108X3M OsmC Ohr family protein E3S62_RS01710 ENOG4108QXE glycerophosphoryl diester phosphodiesterase E3S62_RS01750 ENOG4105EJ9 Membrane E3S62_RS01805 ENOG4105SFS phosphoesterase RecJ domain protein E3S62_RS01815 ENOG4105C6K Malic enzyme E3S62_RS01840 ENOG4105C85 amino acid E3S62_RS01845 ENOG4105BZN citrate synthase E3S62_RS01855 ENOG4105DPZ Two component transcriptional regulator (Winged helix family E3S62_RS01860 ENOG4105BZU Histidine kinase E3S62_RS01870 ENOG4105C2M dna polymerase I E3S62_RS01875 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) E3S62_RS01915 ENOG4108IQI permease E3S62_RS01935 ENOG4105U6W MutT NUDIX family protein E3S62_RS01985 ENOG4105D52 delta-aminolevulinic acid dehydratase E3S62_RS02005 ENOG4108R3E Dna-3-methyladenine glycosylase i E3S62_RS02015 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase E3S62_RS02020 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) E3S62_RS02065 ENOG4105X36 (ribosomal) protein E3S62_RS02105 ENOG4105VIE preprotein translocase, subunit YajC E3S62_RS02110 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) E3S62_RS02115 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) E3S62_RS02160 ENOG4105CUZ uba thif-type nad fad binding protein E3S62_RS02165 ENOG4105D1H recombination factor protein RarA E3S62_RS02185 ENOG4105DEN Luciferase family E3S62_RS02190 ENOG4105C3J Cysteine desulfurase E3S62_RS02205 ENOG4105C7H Helicase, RecD TraA family E3S62_RS02235 ENOG4105XYU peptidase (U32 family) E3S62_RS02240 ENOG4105CFP Peptidase U32 E3S62_RS02255 ENOG4105P4J Allophanate hydrolase, subunit 1 E3S62_RS02265 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein E3S62_RS02270 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase E3S62_RS02280 ENOG4105C5A transporter E3S62_RS02305 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase E3S62_RS02310 ENOG4105CQW ribosome biogenesis GTPase YqeH E3S62_RS02320 ENOG410812S Rna-binding protein E3S62_RS02330 ENOG4108WF2 Metal Dependent Phosphohydrolase E3S62_RS02335 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) E3S62_RS02340 ENOG4105DXX methyltransferase E3S62_RS02345 ENOG4105BZM domain protein E3S62_RS02350 ENOG4108UK2 deaminase E3S62_RS02355 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 E3S62_RS02360 ENOG4105TQK DNA polymerase iii, delta' subunit E3S62_RS02375 ENOG4105CSA Coproporphyrinogen iii oxidase E3S62_RS02405 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) E3S62_RS02410 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) E3S62_RS02420 ENOG4105F7J membrane-bound serine protease E3S62_RS02435 ENOG4105C9A Phoh family E3S62_RS02450 ENOG4105KG3 cytidine deaminase E3S62_RS02485 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) E3S62_RS02500 ENOG4105C1J atp-dependent rna helicase E3S62_RS02510 ENOG4105FDK ABC transporter E3S62_RS02515 ENOG4105FAV ABC, transporter E3S62_RS02520 ENOG4105N80 Ferric uptake regulator, Fur family E3S62_RS02530 ENOG4107RF6 penicillin-binding protein E3S62_RS02540 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase E3S62_RS02565 ENOG4105C5X domain protein E3S62_RS02575 ENOG4105D7Q type ii secretion system E3S62_RS02580 ENOG4106855 Competence protein E3S62_RS02625 ENOG4105WZW rhodanese family E3S62_RS02630 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) E3S62_RS02645 ENOG4105DC7 peptidase M24 E3S62_RS02660 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase E3S62_RS02665 ENOG4108ZSR alkaline shock protein E3S62_RS02695 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) E3S62_RS02710 ENOG4105CPP Dehydrogenase, E1 component E3S62_RS02715 ENOG4105C7S Dehydrogenase E3S62_RS02725 ENOG4108QEG Membrane E3S62_RS02735 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) E3S62_RS02740 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) E3S62_RS02770 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase E3S62_RS02780 ENOG4105II7 pyrroline-5-carboxylate reductase E3S62_RS02785 ENOG4105PDP Short chain dehydrogenase E3S62_RS02795 ENOG4105CPC Aldo Keto reductase E3S62_RS02800 ENOG4108YZ4 nudix hydrolase E3S62_RS02805 ENOG4105I3K Ferric uptake regulator, Fur family E3S62_RS02810 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) E3S62_RS02830 ENOG4105FE9 pseudouridine synthase E3S62_RS02835 ENOG4105CK6 Two component transcriptional regulator (Winged helix family E3S62_RS02840 ENOG4105BZU Histidine kinase E3S62_RS02875 ENOG4105C9U ATP-dependent DNA helicase RecQ E3S62_RS02880 ENOG4106BU8 elastin-binding protein ebpS E3S62_RS02890 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase E3S62_RS02895 ENOG4105HDK L-asparaginase E3S62_RS02915 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) E3S62_RS02930 ENOG4105K70 DNA-binding protein E3S62_RS02945 ENOG4105EAH synthase E3S62_RS02995 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase E3S62_RS03000 ENOG4105CPK Glycosyl transferase (Group 1 E3S62_RS03030 ENOG4105CSM endonuclease III E3S62_RS03040 ENOG4105BZ4 penicillin-binding protein E3S62_RS03070 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) E3S62_RS03085 ENOG410890F Dynamin family E3S62_RS03105 ENOG4107R7I amino acid E3S62_RS03165 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) E3S62_RS03175 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) E3S62_RS03210 ENOG410841Q phosphoesterase PA-phosphatase related protein E3S62_RS03270 ENOG4107T89 von Willebrand factor, type A E3S62_RS03315 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) E3S62_RS03320 ENOG4108XFP Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) E3S62_RS03345 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) E3S62_RS03350 ENOG4105CFH Aspartokinase E3S62_RS03355 ENOG4105C5H ABC transporter E3S62_RS03370 ENOG4105C8U phosphate abc transporter E3S62_RS03375 ENOG4105E2Z phosphate ABC transporter (Permease E3S62_RS03385 ENOG4108UTW Plays a role in the regulation of phosphate uptake E3S62_RS03390 ENOG4105DPN Oligoendopeptidase f E3S62_RS03400 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component E3S62_RS03405 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component E3S62_RS03425 ENOG4108KP7 hydrolase E3S62_RS03430 ENOG4108TV1 Catalyzes the incorporation of amino acid(s) into the interchain peptide bridge of peptidoglycan, using aminoacyl-tRNA as amino acid donor (By similarity) E3S62_RS03435 ENOG4108RMH femAB family E3S62_RS03465 ENOG4105DDQ anthranilate synthase E3S62_RS03470 ENOG4105CRQ synthase (Component I) E3S62_RS03475 ENOG4105DER m42 family E3S62_RS03485 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) E3S62_RS03495 ENOG4108RCF TRANSCRIPTIONal E3S62_RS03500 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) E3S62_RS03530 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E3S62_RS03535 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E3S62_RS03555 ENOG4108I0Z Aconitate hydratase E3S62_RS03560 ENOG4105C94 Transporter E3S62_RS03615 ENOG4105K4I Scp-like extracellular E3S62_RS03645 ENOG4108IQI permease E3S62_RS03670 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) E3S62_RS03675 ENOG4105D6E homoserine dehydrogenase E3S62_RS03680 ENOG4105CFH Aspartokinase E3S62_RS03705 ENOG4108S01 response regulator E3S62_RS03720 ENOG4108M15 ABC transporter E3S62_RS03765 ENOG4105IG6 Phage terminase, large subunit E3S62_RS03870 ENOG4105C5F glutamine synthetase E3S62_RS03875 ENOG4105KV4 Transcriptional regulator E3S62_RS03880 ENOG4105CXI aluminum resistance protein E3S62_RS03885 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) E3S62_RS03890 ENOG4108V06 Glutathione peroxidase E3S62_RS03895 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) E3S62_RS03920 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) E3S62_RS03925 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator E3S62_RS03960 ENOG4105DQU oxidoreductase, subunit beta E3S62_RS03965 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein E3S62_RS03970 ENOG4105D48 metallophosphoesterase E3S62_RS03990 ENOG4105CEV competence damage-inducible protein E3S62_RS03995 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase E3S62_RS04010 ENOG4108RKS Short-chain dehydrogenase reductase Sdr E3S62_RS04025 ENOG4105FDP GntR family transcriptional regulator E3S62_RS04030 ENOG4105CNU cell division protein FtsK E3S62_RS04050 ENOG4105DTN riboflavin biosynthesis protein ribF E3S62_RS04075 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination E3S62_RS04080 ENOG4105CHV Transcription elongation factor NusA E3S62_RS04105 ENOG4105KNE Phosphatidate cytidylyltransferase E3S62_RS04110 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) E3S62_RS04170 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) E3S62_RS04175 ENOG4105C79 DNA protecting protein DprA E3S62_RS04180 ENOG4108RMH femAB family E3S62_RS04190 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha E3S62_RS04205 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) E3S62_RS04245 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) E3S62_RS04250 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) E3S62_RS04265 ENOG4105CHR reductase E3S62_RS04270 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase E3S62_RS04285 ENOG4105CB5 ATP-dependent DNA helicase recG E3S62_RS04295 ENOG4108ZAA Alkaline-shock protein E3S62_RS04310 ENOG4105DJV ribulose-phosphate 3-epimerase E3S62_RS04315 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) E3S62_RS04325 ENOG4108ZF3 Phosphatase E3S62_RS04335 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B E3S62_RS04350 ENOG4105YB8 TM2 domain containing protein E3S62_RS04360 ENOG4105C25 Primosomal protein n' E3S62_RS04365 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase E3S62_RS04380 ENOG4105F23 Fibronectin-binding protein E3S62_RS04395 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) E3S62_RS04410 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain E3S62_RS04415 ENOG4105CD3 dihydroorotase E3S62_RS04435 ENOG4105C34 Pseudouridine synthase E3S62_RS04445 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase E3S62_RS04465 ENOG41067XK integral membrane protein E3S62_RS04475 ENOG4105DFA alanine racemase domain protein E3S62_RS04485 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) E3S62_RS04490 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) E3S62_RS04510 ENOG4105CJN penicillin-binding protein E3S62_RS04515 ENOG41068DC Essential cell division protein (By similarity) E3S62_RS04575 ENOG4105CSX c4-dicarboxylate anaerobic carrier E3S62_RS04585 ENOG4105DBV ornithine carbamoyltransferase E3S62_RS04615 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity E3S62_RS04675 ENOG4105E33 succinate dehydrogenase E3S62_RS04685 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit E3S62_RS04710 ENOG4105DCG PHP domain protein E3S62_RS04740 ENOG4108RWN rrna methyltransferase E3S62_RS04755 ENOG4105KFN sortase, SrtB family E3S62_RS04810 ENOG4106H78 methyltransferase E3S62_RS04825 ENOG4107VXM glycerophosphoryl diester phosphodiesterase E3S62_RS04855 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) E3S62_RS04860 ENOG4105CNI cell division protein FtsW E3S62_RS04880 ENOG4105CI3 gtp-binding protein typa E3S62_RS04890 ENOG4105ECY inositol monophosphatase E3S62_RS04915 ENOG4107RUE extracellular solute-binding protein family 1 E3S62_RS04920 ENOG4105D38 putrescine abc transporter E3S62_RS04925 ENOG4105F38 ABC transporter, permease E3S62_RS04945 ENOG4107QN2 dihydrolipoyl dehydrogenase E3S62_RS04950 ENOG4105C7S Dehydrogenase E3S62_RS04955 ENOG4105CPP Dehydrogenase, E1 component E3S62_RS04970 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) E3S62_RS04990 ENOG4107ZYR domain protein E3S62_RS05005 ENOG41067VN Glutaredoxin E3S62_RS05015 ENOG4105KRI phosphocarrier protein (HPr E3S62_RS05025 ENOG4105DR4 Methyltransferase E3S62_RS05045 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein E3S62_RS05050 ENOG4108JJB ABC transporter E3S62_RS05055 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) E3S62_RS05070 ENOG4108V3E phosphoribosylglycinamide formyltransferase E3S62_RS05080 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase E3S62_RS05095 ENOG4105VR9 phosphoribosylformylglycinamidine synthase E3S62_RS05105 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit E3S62_RS05110 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) E3S62_RS05155 ENOG4108KGH TRANSCRIPTIONal E3S62_RS05165 ENOG41082BV acetyltransferase E3S62_RS05185 ENOG4108TGC Acyltransferase E3S62_RS05190 ENOG4105CHM Aminotransferase E3S62_RS05210 ENOG4108IPT Naphthoate synthase E3S62_RS05225 ENOG4105E4F Isochorismate synthase E3S62_RS05235 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase E3S62_RS05240 ENOG41080E2 ribosomal-protein-alanine acetyltransferase E3S62_RS05245 ENOG4105YB8 TM2 domain containing protein E3S62_RS05255 ENOG4108HUF Transporter E3S62_RS05270 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) E3S62_RS05320 ENOG4105XVF Competence transcription factor E3S62_RS05335 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic E3S62_RS05350 ENOG4107TS3 membrane protein, TerC E3S62_RS05390 ENOG4105BZG amino acid carrier protein E3S62_RS05395 ENOG4105C02 permease E3S62_RS05410 ENOG4105CJW magnesium transporter E3S62_RS05415 ENOG4105EMS pseudouridine synthase E3S62_RS05430 ENOG4106EFP UPF0738 protein E3S62_RS05440 ENOG4108Z18 K06886 hemoglobin E3S62_RS05445 ENOG4105T58 Dithiol-disulfide isomerase E3S62_RS05450 ENOG4105DPN Oligoendopeptidase f E3S62_RS05465 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) E3S62_RS05470 ENOG4105C31 Tryptophanyl-tRNA synthetase E3S62_RS05475 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component E3S62_RS05485 ENOG4108JQ7 (ABC) transporter E3S62_RS05495 ENOG4105DEF Extracellular solute-binding protein, family 5 E3S62_RS05505 ENOG4108JQ7 (ABC) transporter E3S62_RS05515 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component E3S62_RS05520 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component E3S62_RS05530 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) E3S62_RS05550 ENOG4105KIS phospholipid-binding protein E3S62_RS05560 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit E3S62_RS05575 ENOG4108KP7 hydrolase E3S62_RS05595 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation E3S62_RS05635 ENOG4107VXM glycerophosphoryl diester phosphodiesterase E3S62_RS05640 ENOG4105D82 Glutamate dehydrogenase E3S62_RS05645 ENOG4105C8Y Acetylornithine aminotransferase E3S62_RS05650 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase E3S62_RS05655 ENOG41060GV RNA binding s1 domain protein E3S62_RS05710 ENOG4105KA0 thioesterase Superfamily protein E3S62_RS05720 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) E3S62_RS05730 ENOG4108YX9 iron--sulfur cluster insertion protein erpA E3S62_RS05750 ENOG41083MR nifu domain-containing protein E3S62_RS05755 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD E3S62_RS05765 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein E3S62_RS05805 ENOG4105MMD transcriptional regulator E3S62_RS05825 ENOG4105I3N Conserved Protein E3S62_RS05855 ENOG4108UNV SUF system FeS assembly protein, NifU family E3S62_RS05860 ENOG4105C9B Cysteine desulfurase E3S62_RS05865 ENOG4105JRK feS assembly protein SufD E3S62_RS05870 ENOG4105C3K feS assembly ATPase SufC E3S62_RS05885 ENOG4105D01 (LipO)protein E3S62_RS05890 ENOG4108UMI ABC transporter, permease E3S62_RS05895 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) E3S62_RS05910 ENOG4108XI2 Domain of unknown function (DUF1963) E3S62_RS05925 ENOG41080E8 Transcriptional regulator, Spx MgsR family E3S62_RS05930 ENOG4105SZ6 Thioredoxin E3S62_RS05955 ENOG4108ZUB Lysine exporter protein (Lyse ygga) E3S62_RS05960 ENOG4105CVJ phosphoglycerate mutase E3S62_RS06000 ENOG4105VEQ Cold shock protein E3S62_RS06065 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) E3S62_RS06075 ENOG4105XZU Preprotein translocase, subunit SecG E3S62_RS06105 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase E3S62_RS06125 ENOG4105C6K Malic enzyme E3S62_RS06140 ENOG4105CHW UPF0052 protein E3S62_RS06150 ENOG4105C3M thioredoxin reductase E3S62_RS06160 ENOG4108S4C acetyltransferase E3S62_RS06180 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) E3S62_RS06195 ENOG41068JE domain protein E3S62_RS06220 ENOG41081UC Inherit from COG: Competence protein E3S62_RS06235 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein E3S62_RS06240 ENOG4105ESV Glycosyl transferase, family 4 E3S62_RS06300 ENOG4108IPW abc transporter atp-binding protein E3S62_RS06305 ENOG4105CM4 permease protein E3S62_RS06310 ENOG4105DHS permease protein E3S62_RS06315 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) E3S62_RS06320 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) E3S62_RS06340 ENOG4105DUX Transporter E3S62_RS06355 ENOG4108ZIE 5 nucleotidase deoxy cytosolic type C E3S62_RS06365 ENOG4105E90 ABC transporter E3S62_RS06370 ENOG4108IJ8 ABC transporter E3S62_RS06375 ENOG4105C9U ATP-dependent DNA helicase RecQ E3S62_RS06380 ENOG4105C5H ABC transporter E3S62_RS06410 ENOG4105CRQ synthase (Component I) E3S62_RS06415 ENOG4105DDQ anthranilate synthase E3S62_RS06425 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase E3S62_RS06430 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) E3S62_RS06460 ENOG4105CKK Glycosyl transferase, family 2 E3S62_RS06470 ENOG4105C37 (CBS) domain E3S62_RS06475 ENOG4105CE4 GlcNAc 6-P deacetylase E3S62_RS06480 ENOG4105DM4 PTS System E3S62_RS06485 ENOG4105DE4 1-phosphofructokinase E3S62_RS06490 ENOG4105E98 transcriptional regulator DeoR family E3S62_RS06495 ENOG4108Z66 YbaK ebsC protein E3S62_RS06525 ENOG4105CVP deoxyribo-dipyrimidine photolyase E3S62_RS06530 ENOG4107QPK )-transporter E3S62_RS06540 ENOG4107QM2 Aldo Keto reductase E3S62_RS06545 ENOG4105CKI cobalamin synthesis protein E3S62_RS06550 ENOG41083AI transcriptional regulator), MarR family E3S62_RS06555 ENOG4108JJ8 (ABC) transporter E3S62_RS06560 ENOG4108JJ9 ABC, transporter E3S62_RS06580 ENOG4108URH decarboxylase E3S62_RS06585 ENOG4108YYQ gCN5-related N-acetyltransferase E3S62_RS06610 ENOG4105SXS Protein of unknown function (DUF456) E3S62_RS06615 ENOG4105S8Q sugar efflux transporter E3S62_RS06650 ENOG4105ID8 Transcriptional regulator, ARAC family E3S62_RS06660 ENOG4105VRS hydrolase family 18 E3S62_RS06665 ENOG4105CJ3 phosphate transporter E3S62_RS06670 ENOG4107GRR phosphate transport regulator E3S62_RS06680 ENOG4105C19 ABC transporter E3S62_RS06715 ENOG4108K88 Membrane E3S62_RS06725 ENOG4105VDH Dihydroxyacetone kinase E3S62_RS06735 ENOG4105CMT Dihydroxyacetone kinase E3S62_RS06740 ENOG4105EHG Permease protein E3S62_RS06745 ENOG4105DQ5 transport system permease protein E3S62_RS06750 ENOG4105E0A ABC, transporter E3S62_RS06755 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) E3S62_RS06770 ENOG4105BZ1 (ABC) transporter E3S62_RS06780 ENOG4107YSK Glycerol-3-phosphate cytidylyltransferase E3S62_RS06805 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family E3S62_RS06815 ENOG4107R5H iron (metal) dependent repressor, dtxr family E3S62_RS06820 ENOG4105DIK (ABC) transporter E3S62_RS06825 ENOG4105CC5 ABC transporter E3S62_RS06830 ENOG4105DSE periplasmic solute binding protein E3S62_RS06835 ENOG4105EEQ Na H antiporter E3S62_RS06875 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) E3S62_RS06915 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) E3S62_RS06925 ENOG4105EHG Permease protein E3S62_RS06930 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) E3S62_RS06960 ENOG4108XFG YwhD family E3S62_RS06965 ENOG4105DCI Phosphohydrolase E3S62_RS06975 ENOG4108WS4 fmn reductase E3S62_RS06980 ENOG4105CPC Aldo Keto reductase E3S62_RS07025 ENOG4107QN2 dihydrolipoyl dehydrogenase E3S62_RS07045 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) E3S62_RS07050 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) E3S62_RS07055 ENOG4108IJ2 phosphate acetyltransferase E3S62_RS07095 ENOG4105DWF phosphomethylpyrimidine kinase E3S62_RS07155 ENOG4107YEI lmbE family E3S62_RS07175 ENOG4105DUY Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein E3S62_RS07180 ENOG4105DUY Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein E3S62_RS07195 ENOG410667J hydrolase E3S62_RS07200 ENOG4108Z6B deaminase E3S62_RS07210 ENOG4105ZMH deoxynucleoside kinase E3S62_RS07240 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) E3S62_RS07275 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) E3S62_RS07285 ENOG4107Y49 methyltransferase E3S62_RS07315 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) E3S62_RS07320 ENOG410683Z Preprotein translocase SecE subunit E3S62_RS07340 ENOG4105C2N RNA methyltransferase TrmH family group 3 E3S62_RS07345 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) E3S62_RS07365 ENOG4105CTP PilT protein domain protein E3S62_RS07370 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) E3S62_RS07385 ENOG4108Z0C Uvrb UvrC protein E3S62_RS07395 ENOG4105D9N nucleoside E3S62_RS07410 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family E3S62_RS07505 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase E3S62_RS07520 ENOG4105C6T cysteine synthase E3S62_RS07530 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) E3S62_RS07535 ENOG4108UGV hypoxanthine phosphoribosyltransferase E3S62_RS07545 ENOG41060GV RNA binding s1 domain protein E3S62_RS07555 ENOG41082I2 s4 domain protein E3S62_RS07560 ENOG4108IY2 MazG family E3S62_RS07585 ENOG4105C5T Phosphoribosyl pyrophosphate synthase E3S62_RS07605 ENOG4105KME endoribonuclease L-psp E3S62_RS07610 ENOG4105DFT pur operon repressor E3S62_RS07620 ENOG4105W42 Veg protein E3S62_RS07630 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) E3S62_RS07635 ENOG4105F8V Hydrolase, tatD family E3S62_RS07645 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) E3S62_RS07655 ENOG41060K3 Methyltransferase E3S62_RS07665 ENOG4105MA4 psp1 domain protein E3S62_RS07670 ENOG4105FA2 dna polymerase iii E3S62_RS07675 ENOG4105X0R protein from nitrogen regulatory protein P-II E3S62_RS07685 ENOG4105CXN decarboxylase E3S62_RS07715 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) E3S62_RS07720 ENOG4105C6E dna polymerase iii E3S62_RS07740 ENOG4107414 GntR family transcriptional regulator E3S62_RS07745 ENOG4105CG3 alpha amylase, catalytic region E3S62_RS07750 ENOG4105C5Y PTS System E3S62_RS07760 ENOG4105BZ8 glutamate synthase E3S62_RS07765 ENOG4105CBC glutamate synthase E3S62_RS07770 ENOG4105C5Q Transcriptional regulator E3S62_RS07805 ENOG4105D01 (LipO)protein E3S62_RS07810 ENOG4108UMI ABC transporter, permease E3S62_RS07820 ENOG4105C28 cystathionine E3S62_RS07830 ENOG4105C8J )-transporter E3S62_RS07855 ENOG4105GPN Uncharacterized conserved protein (DUF2294) E3S62_RS07865 ENOG4108TWJ NADH dehydrogenase subunit 5 E3S62_RS07890 ENOG4105CKI cobalamin synthesis protein E3S62_RS08005 ENOG4105KA3 membrAne E3S62_RS08010 ENOG4105EWC Purine nucleoside phosphorylase E3S62_RS08015 ENOG4105G7B Protein of unknown function (DUF2992) E3S62_RS08085 ENOG4105C2W permease E3S62_RS08115 ENOG4107R6U sodium dicarboxylate symporter E3S62_RS08130 ENOG4108JU3 Alkyl hydroperoxide reductase E3S62_RS08205 ENOG4108UUM single-stranded DNA-binding protein E3S62_RS08220 ENOG4105C3G gtp-binding protein E3S62_RS08225 ENOG4105VDK protein, conserved in bacteria E3S62_RS08230 ENOG4105D8X mechanosensitive ion channel E3S62_RS08235 ENOG4105FA0 parb-like partition protein E3S62_RS08240 ENOG4105C28 cystathionine E3S62_RS08245 ENOG4105C28 cystathionine E3S62_RS08280 ENOG4105CJ1 ABC, transporter E3S62_RS08290 ENOG4105VZ8 Transcriptional regulator E3S62_RS08300 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) E3S62_RS08310 ENOG4107SJW iron permease, FTR1 E3S62_RS08315 ENOG4105DBE peroxidase E3S62_RS08320 ENOG410650H (LipO)protein E3S62_RS08330 ENOG4105HMI Membrane E3S62_RS08335 ENOG4107V0Z fmn reductase E3S62_RS08350 ENOG4105CXY transporter E3S62_RS08370 ENOG4105ETD TRANSCRIPTIONal E3S62_RS08375 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia E3S62_RS08385 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC E3S62_RS08410 ENOG4105DEN Luciferase family E3S62_RS08435 ENOG4105DWD nucleoside recognition domain protein E3S62_RS08445 ENOG4106KNT transcriptional regulator E3S62_RS08450 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) E3S62_RS08460 ENOG4107RJ1 sodium solute E3S62_RS08490 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) E3S62_RS08495 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) E3S62_RS08500 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family E3S62_RS08560 ENOG4108Q9H CobQ/CobB/MinD/ParA nucleotide binding domain E3S62_RS08585 ENOG4108U7W acetyltransferase E3S62_RS08590 ENOG41075D4 Aminoglycoside 6-adenylyltransferase E3S62_RS08595 ENOG4105DMQ Methyltransferase E3S62_RS08610 ENOG4105MKU Transcriptional regulator E3S62_RS08630 ENOG4108BUD transposase E3S62_RS08705 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) E3S62_RS08845 ENOG4105EC2 ftsk spoIIIe E3S62_RS08855 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) E3S62_RS08875 ENOG4105VRS hydrolase family 18 E3S62_RS08905 ENOG4108M15 ABC transporter E3S62_RS08910 ENOG41061JJ Peptidase family M23 E3S62_RS08935 ENOG4105EV1 Ribose uptake protein RbsU E3S62_RS08955 ENOG4105DVA methyltransferase E3S62_RS08960 ENOG4105CS2 ec 3.2.1.21 E3S62_RS08965 ENOG4105CI1 PTS System E3S62_RS09005 ENOG4107RZX Teichoic acid biosynthesis protein E3S62_RS09010 ENOG4105EJJ Dehydrogenase E3S62_RS09020 ENOG4107SJB teichoic acid biosynthesis E3S62_RS09025 ENOG4107RZX Teichoic acid biosynthesis protein E3S62_RS09030 ENOG4105EJJ Dehydrogenase E3S62_RS09035 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) E3S62_RS09040 ENOG4105CPQ Dehydrogenase E3S62_RS09050 ENOG4105CPQ Dehydrogenase E3S62_RS09055 ENOG4105DT3 PTS system, galactitol-specific IIc component E3S62_RS09060 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) E3S62_RS09075 ENOG4105DU0 nucleoside hydrolase E3S62_RS09080 ENOG4105CI1 PTS System E3S62_RS09105 ENOG4105K78 MarR family Transcriptional regulator E3S62_RS09110 ENOG4107RRN ABC transporter substrate-binding protein E3S62_RS09115 ENOG4105ENX hydrolase E3S62_RS09140 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) E3S62_RS09145 ENOG4105CEY Amp-dependent synthetase and ligase E3S62_RS09150 ENOG4105C1G acyl-Coa dehydrogenase E3S62_RS09155 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase E3S62_RS09160 ENOG4105CHU acetyl-coa acetyltransferase E3S62_RS09200 ENOG4105C2F Histidine kinase E3S62_RS09205 ENOG4107VQW regulatoR E3S62_RS09210 ENOG4105CXY transporter E3S62_RS09215 ENOG4108WWS isoprenylcysteine carboxyl methyltransferase E3S62_RS09225 ENOG4105CK5 oxidoreductase E3S62_RS09235 ENOG4105EG2 ABC transporter, permease E3S62_RS09270 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) E3S62_RS09280 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component E3S62_RS09285 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component E3S62_RS09310 ENOG4105QEK Transcriptional regulator E3S62_RS09340 ENOG4107RA9 decarboxylase E3S62_RS09345 ENOG4105D3W isochorismatase E3S62_RS09350 ENOG4105CWM branched-chain amino acid transport system II carrier protein E3S62_RS09360 ENOG4105C8Y Acetylornithine aminotransferase E3S62_RS09400 ENOG4105C1G acyl-Coa dehydrogenase E3S62_RS09430 ENOG4105PGM cation diffusion facilitator family transporter E3S62_RS09435 ENOG4105C26 Dehydrogenase E3S62_RS09440 ENOG4105WD1 Membrane E3S62_RS09450 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase E3S62_RS09465 ENOG4105D3Q Sugar transferase E3S62_RS09495 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase E3S62_RS09505 ENOG4105C5E polysaccharide biosynthesis protein E3S62_RS09525 ENOG4105HTX biosynthesis protein E3S62_RS09530 ENOG4108EKI Dehydrogenase E3S62_RS09540 ENOG4105CGH 5'-nucleotidase E3S62_RS09575 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) E3S62_RS09580 ENOG4108J8C transporter major facilitator family protein E3S62_RS09585 ENOG4105D3A purine nucleoside phosphorylase DeoD-type E3S62_RS09615 ENOG4105CPK Glycosyl transferase (Group 1 E3S62_RS09625 ENOG4108IAJ Nad-dependent epimerase dehydratase E3S62_RS09630 ENOG4105CHR reductase E3S62_RS09650 ENOG41067FT ParB-like nuclease domain E3S62_RS09655 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) E3S62_RS09665 ENOG4105DUU IucA IucC family protein E3S62_RS09670 ENOG4105DBM Siderophore biosynthesis protein E3S62_RS09675 ENOG4105C6X Major Facilitator E3S62_RS09680 ENOG4105DJU Siderophore biosynthesis protein E3S62_RS09685 ENOG4105CIF Ornithine Cyclodeaminase E3S62_RS09695 ENOG4108MES Periplasmic binding protein E3S62_RS09700 ENOG4105DQ5 transport system permease protein E3S62_RS09705 ENOG4108IHU transport system permease protein E3S62_RS09735 ENOG4107Y9U Membrane E3S62_RS09740 ENOG4105CCI Myosin-Cross-Reactive Antigen E3S62_RS09750 ENOG4105C57 major facilitator superfamily E3S62_RS09770 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C E3S62_RS09780 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) E3S62_RS09790 ENOG4105ENX hydrolase E3S62_RS09805 ENOG4108WS4 fmn reductase E3S62_RS09835 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase E3S62_RS09840 ENOG4107TJV N-acetylglutamate semialdehyde dehydrogenase E3S62_RS09845 ENOG4108KB0 deacetylase E3S62_RS09850 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) E3S62_RS09855 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) E3S62_RS09860 ENOG4105C12 Phosphoribosylglycinamide synthetase E3S62_RS09895 ENOG4108YM7 Gcn5-related n-acetyltransferase E3S62_RS09930 ENOG4105CVR type I restriction-modification system E3S62_RS09950 ENOG4105CB5 ATP-dependent DNA helicase recG E3S62_RS10010 ENOG4105CCN Peptidase M56 E3S62_RS10015 ENOG4107RVG penicillin-binding protein E3S62_RS10020 ENOG4108ZMQ domain protein E3S62_RS10025 ENOG4108QXE glycerophosphoryl diester phosphodiesterase E3S62_RS10030 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase E3S62_RS10055 ENOG4105CGH 5'-nucleotidase E3S62_RS10060 ENOG4105Q2H domain protein E3S62_RS10095 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis E3S62_RS10100 ENOG4105CDU Replicative dna helicase E3S62_RS10110 ENOG4105BZR domain protein E3S62_RS10120 ENOG4105DWV Homoserine O-trans-acetylase E3S62_RS10145 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) E3S62_RS10150 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E3S62_RS10165 ENOG410848D S4 domain protein YaaA E3S62_RS10170 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) E3S62_RS10205 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) E3S62_RS10245 ENOG4105C19 ABC transporter E3S62_RS10260 ENOG4105D9G High-affinity E3S62_RS10270 ENOG4105FR1 rard protein E3S62_RS10275 ENOG4107QPK )-transporter E3S62_RS10335 ENOG4105CIH Imidazole acetol-phosphate transaminase E3S62_RS10360 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase E3S62_RS10370 ENOG4105J1V Triacylglycerol lipase E3S62_RS10390 ENOG4107QJZ Glycosyl transferase, family 2 E3S62_RS10395 ENOG4108IG5 Transcriptional regulator E3S62_RS10420 ENOG4108F19 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) E3S62_RS10425 ENOG4107XC4 flavin reductase domain protein, FMN-binding E3S62_RS10450 ENOG4105EW6 flavin reductase domain protein, FMN-binding E3S62_RS10455 ENOG4106432 Mediates binding to human platelets, possibly through a receptor-ligand interaction. Probably associated with virulence in endovascular infection (By similarity) E3S62_RS10460 ENOG4106YAG Part of the accessory SecA2 SecY2 system specifically required for export of E3S62_RS10465 ENOG4108XJK accessory Sec system protein Asp1 E3S62_RS10470 ENOG41089G2 accessory Sec system protein Asp2 E3S62_RS10475 ENOG4106E62 Accessory Sec system protein Asp3 E3S62_RS10500 ENOG4105WQI isochorismatase E3S62_RS10505 ENOG4108S4A n-acetylmuramoyl-l-alanine amidase E3S62_RS10515 ENOG4105DG6 mannose-6-phosphate isomerase E3S62_RS10520 ENOG4105DM4 PTS System E3S62_RS10545 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) E3S62_RS10555 ENOG4105CEU Arginine dihydrolase E3S62_RS10560 ENOG4105DBV ornithine carbamoyltransferase E3S62_RS10570 ENOG4105C5B carbamate kinase E3S62_RS10580 ENOG4105T6C Cell surface-associated protein implicated in virulence by promoting bacterial attachment to both alpha- and beta-chains of human fibrinogen and inducing the formation of bacterial clumps E3S62_RS10580 ENOG4105T6C Cell surface-associated protein implicated in virulence by promoting bacterial attachment to both alpha- and beta-chains of human fibrinogen and inducing the formation of bacterial clumps E3S62_RS10590 ENOG4108U05 Transcriptional regulator E3S62_RS10600 ENOG4105G6Z alkaline phosphatase E3S62_RS10650 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) E3S62_RS10655 ENOG4108Z73 Siroheme synthase E3S62_RS10665 ENOG4105D4T Citrate transporter E3S62_RS10670 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase E3S62_RS10675 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) E3S62_RS10690 ENOG4105C94 Transporter E3S62_RS10695 ENOG4105TRT Transcriptional regulator E3S62_RS10705 ENOG4105C26 Dehydrogenase E3S62_RS10725 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) E3S62_RS10735 ENOG4105DWT malate dehydrogenase (quinone) E3S62_RS10750 ENOG4108JPW Aminotransferase E3S62_RS10755 ENOG4105CUB amino acid E3S62_RS10765 ENOG4107FQX Alpha-acetolactate decarboxylase E3S62_RS10770 ENOG4108NKJ Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) E3S62_RS10820 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) E3S62_RS10825 ENOG4105FGM Fructosamine kinase E3S62_RS10845 ENOG4107T5J pyridine nucleotide-disulfide oxidoreductase E3S62_RS10860 ENOG4108SXP alpha beta E3S62_RS10870 ENOG4105CHR reductase E3S62_RS10925 ENOG4105KY5 gCN5-related N-acetyltransferase E3S62_RS10930 ENOG4105EXC Acyl-transferase E3S62_RS10980 ENOG4105C59 p-type ATPase E3S62_RS11010 ENOG4105EYF MMPL domain protein E3S62_RS11035 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) E3S62_RS11040 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase E3S62_RS11050 ENOG41068JE domain protein E3S62_RS11060 ENOG4105CMU LysR family (Transcriptional regulator E3S62_RS11100 ENOG4108UZ3 Transporter E3S62_RS11120 ENOG4105EJQ L-serine dehydratase E3S62_RS11135 ENOG4108Z7F N-acetyltransferase E3S62_RS11140 ENOG4108Z6X (sortase) family E3S62_RS11145 ENOG4106KKU E3S62_RS11150 ENOG4108Z15 abc transporter atp-binding protein E3S62_RS11155 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) E3S62_RS11160 ENOG4105C5I Dehydrogenase E3S62_RS11170 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase E3S62_RS11180 ENOG41090MY MarR family Transcriptional regulator E3S62_RS11190 ENOG4105FBA Phospholipase Carboxylesterase E3S62_RS11210 ENOG4105CJ1 ABC, transporter E3S62_RS11220 ENOG4107T5V SNARE associated Golgi E3S62_RS11225 ENOG4105DJB Major Facilitator Superfamily E3S62_RS11235 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) E3S62_RS11250 ENOG4105G3Z GntR family transcriptional regulator E3S62_RS11255 ENOG4105CMG Carbohydrate kinase E3S62_RS11300 ENOG4105M6F mutator MutT protein E3S62_RS11395 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) E3S62_RS11400 ENOG4105CFC Transporter E3S62_RS11405 ENOG41061TZ Short-chain dehydrogenase reductase Sdr E3S62_RS11410 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein E3S62_RS11430 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein E3S62_RS11435 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component E3S62_RS11440 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component E3S62_RS11450 ENOG4108S9F abc transporter, atp-binding protein E3S62_RS11465 ENOG4105CBC glutamate synthase E3S62_RS11470 ENOG4105PQ4 (LipO)protein E3S62_RS11475 ENOG4105CN9 Peptidase m42 family protein E3S62_RS11480 ENOG41083J0 (ABC) transporter E3S62_RS11485 ENOG4105C4B ABC transporter, permease E3S62_RS11490 ENOG4105F27 Major Facilitator E3S62_RS11495 ENOG4105EBR Carboxylesterase E3S62_RS11505 ENOG4105CZ9 Domain of unknown function (DU1801) E3S62_RS11525 ENOG4105E90 ABC transporter E3S62_RS11535 ENOG4105R40 Glycine betaine carnitine choline E3S62_RS11540 ENOG4105C57 major facilitator superfamily E3S62_RS11545 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) E3S62_RS11560 ENOG4105C0X amino acid E3S62_RS11565 ENOG4105EEQ Na H antiporter E3S62_RS11570 ENOG4105C85 amino acid E3S62_RS11590 ENOG4105C2C drug resistance transporter, Bcr CflA E3S62_RS11600 ENOG4105BZW Glycerate kinase E3S62_RS11625 ENOG4105BZ1 (ABC) transporter E3S62_RS11635 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) E3S62_RS11640 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) E3S62_RS11650 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) E3S62_RS11710 ENOG4105EAB amino acid AbC transporter E3S62_RS11715 ENOG4105DRP amino acid AbC transporter E3S62_RS11720 ENOG4105CDA abc transporter atp-binding protein E3S62_RS11740 ENOG4105DSE periplasmic solute binding protein E3S62_RS11755 ENOG4105TMB Formate nitrite transporter E3S62_RS11760 ENOG4108XSB acetyltransferase, (GNAT) family E3S62_RS11770 ENOG4108IFG nitrite reductase, (NAD(P)H) E3S62_RS11775 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit E3S62_RS11780 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) E3S62_RS11790 ENOG4108IUE nitrate reductase beta subunit E3S62_RS11820 ENOG4107TXC Transcriptional regulator E3S62_RS11860 ENOG410606W general stress protein E3S62_RS11890 ENOG4105ECB domain protein E3S62_RS11940 ENOG4105DWT malate dehydrogenase (quinone) E3S62_RS11950 ENOG4105CJ1 ABC, transporter E3S62_RS11995 ENOG41062A4 Transcriptional regulator E3S62_RS12020 ENOG4105CW7 secretion protein, HlyD family E3S62_RS12025 ENOG4105C0R drug resistance transporter emrb qaca subfamily E3S62_RS12050 ENOG4105D7N magnesium and cobalt transport protein CorA E3S62_RS12060 ENOG4105D6U Sodium Glutamate Symporter E3S62_RS12070 ENOG4105KAF membrAne E3S62_RS12075 ENOG4108IUX (ABC) transporter E3S62_RS12080 ENOG4105RHA ABC transporter, permease E3S62_RS12100 ENOG4108RPX mosc domain containing protein E3S62_RS12120 ENOG4105C5Q Transcriptional regulator E3S62_RS12125 ENOG4105CGP Urocanate hydratase E3S62_RS12135 ENOG4105CH2 amidohydrolase E3S62_RS12140 ENOG4105CYX Short-chain dehydrogenase reductase Sdr E3S62_RS12160 ENOG4108Q3X Transcriptional regulator E3S62_RS12165 ENOG4105CI1 PTS System E3S62_RS12175 ENOG4105C09 Bile acid E3S62_RS12180 ENOG4107YBY Hydrolase E3S62_RS12255 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis E3S62_RS12285 ENOG4105DFD Na H antiporter E3S62_RS12360 ENOG4105FDT acyl-CoA dehydrogenase E3S62_RS12375 ENOG4107ZYJ bioY protein E3S62_RS12390 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein E3S62_RS12395 ENOG4105E0C molybdate abc transporter E3S62_RS12400 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) E3S62_RS12405 ENOG4105D06 uba thif-type nad fad binding protein E3S62_RS12410 ENOG4105EPU Molybdenum cofactor synthesis domain protein E3S62_RS12425 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein E3S62_RS12430 ENOG4108ZAF Molybdopterin E3S62_RS12510 ENOG4105CSC Glucose uptake protein E3S62_RS12530 ENOG4105C7N Xanthine uracil vitamin C permease E3S62_RS12645 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) E3S62_RS12650 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) E3S62_RS12715 ENOG4105CB5 ATP-dependent DNA helicase recG E3S62_RS12735 ENOG4107FQX Alpha-acetolactate decarboxylase E3S62_RS12750 ENOG4105CG5 Glycosyl transferase (Group 1 E3S62_RS12765 ENOG4106AM8 polysaccharide lyase family 8 E3S62_RS12775 ENOG4105VUF Transcriptional regulator E3S62_RS12820 ENOG4105VCP PTS System E3S62_RS12825 ENOG4105CK1 PTS System E3S62_RS12840 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein E3S62_RS12855 ENOG4105C94 Transporter E3S62_RS12880 ENOG4107SFI Major Facilitator superfamily E3S62_RS12890 ENOG4106M28 alanine racemase domain protein E3S62_RS12900 ENOG4108HUF Transporter E3S62_RS12905 ENOG4105DQ5 transport system permease protein E3S62_RS12910 ENOG4108U1V ABC transporter, permease E3S62_RS12915 ENOG4105DWD nucleoside recognition domain protein E3S62_RS12925 ENOG4107K5X Membrane-bound metal-dependent hydrolase E3S62_RS12935 ENOG4108UT2 hemolysin iii E3S62_RS12955 ENOG4105D1F ATP-binding protein E3S62_RS13015 ENOG4105C8B TIGR00159 family E3S62_RS13040 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein E3S62_RS13045 ENOG4105ETD TRANSCRIPTIONal E3S62_RS13055 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) E3S62_RS13060 ENOG4105DKW ABC transporter E3S62_RS13080 ENOG4105PGM cation diffusion facilitator family transporter E3S62_RS13095 ENOG4105DG6 mannose-6-phosphate isomerase E3S62_RS13115 ENOG4108RMU ferritin dps family protein E3S62_RS13120 ENOG4105D3A purine nucleoside phosphorylase DeoD-type E3S62_RS13125 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) E3S62_RS13185 ENOG4105D2N Aldolase E3S62_RS13205 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) E3S62_RS13225 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) E3S62_RS13230 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) E3S62_RS13255 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase E3S62_RS13345 ENOG4105DWF phosphomethylpyrimidine kinase E3S62_RS13370 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) E3S62_RS13375 ENOG4105VPX protein, conserved in bacteria E3S62_RS13400 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) E3S62_RS13410 ENOG4105EEX Two component transcriptional regulator (Winged helix family E3S62_RS13415 ENOG4105C08 Histidine kinase E3S62_RS13445 ENOG4105CKV Membrane E3S62_RS13475 ENOG4107SGM protein serine threonine phosphatase E3S62_RS13480 ENOG4105WN5 stage II sporulation protein E3S62_RS13550 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) E3S62_RS13570 ENOG4105C7K acetolactate synthase E3S62_RS13585 ENOG4105K8N protein family UPF0079, ATPase E3S62_RS13590 ENOG41072GX Peptidase M22 Glycoprotease E3S62_RS13595 ENOG410801F ribosomal-protein-alanine acetyltransferase E3S62_RS13605 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) E3S62_RS13615 ENOG4105C5H ABC transporter E3S62_RS13625 ENOG4105CUC YeeE YedE family protein E3S62_RS13635 ENOG4105BZU Histidine kinase E3S62_RS13660 ENOG4108WCX response regulator E3S62_RS13720 ENOG4105CZN Potassium uptake protein E3S62_RS13770 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) E3S62_RS13850 ENOG4108UUM single-stranded DNA-binding protein