locus-tag class description E3S99_RS00020 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) E3S99_RS00075 ENOG4105DR5 peptidase E3S99_RS00120 ENOG4105ZMJ n-acetylmuramoyl-l-alanine amidase E3S99_RS00130 ENOG4105ZMJ n-acetylmuramoyl-l-alanine amidase E3S99_RS00180 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family E3S99_RS00195 ENOG4105CJ1 ABC, transporter E3S99_RS00245 ENOG4105C26 Dehydrogenase E3S99_RS00270 ENOG4105C8P )-transporter E3S99_RS00280 ENOG4105CQC Prephenate dehydratase E3S99_RS00285 ENOG4107QN4 Catalyzes the production of nitric oxide (By similarity) E3S99_RS00290 ENOG4105DAP Nicotinate phosphoribosyltransferase E3S99_RS00325 ENOG4105KGF protein, YerC YecD E3S99_RS00335 ENOG4105C4R Atp-dependent dna helicase E3S99_RS00390 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) E3S99_RS00450 ENOG4105ENE Histidine kinase E3S99_RS00460 ENOG4107U9T Pfam:Ribonuclease_BN E3S99_RS00485 ENOG4108S4H thioesterase Superfamily protein E3S99_RS00495 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) E3S99_RS00575 ENOG4108UUM single-stranded DNA-binding protein E3S99_RS00595 ENOG4106CVF DNA replication protein E3S99_RS00805 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis E3S99_RS00825 ENOG4105ZMJ n-acetylmuramoyl-l-alanine amidase E3S99_RS00860 ENOG4105EY8 ABC transporter E3S99_RS00870 ENOG41067AE Membrane-bound metal-dependent hydrolase E3S99_RS00875 ENOG4105CEN a g-specific adenine glycosylase E3S99_RS00895 ENOG4107NBY Membrane E3S99_RS00905 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen E3S99_RS00910 ENOG4108M3J Dehydrogenase E3S99_RS01075 ENOG4105E5Q amino acid AbC transporter E3S99_RS01080 ENOG4105CDA abc transporter atp-binding protein E3S99_RS01085 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) E3S99_RS01115 ENOG4108YBP pseudouridine synthase E3S99_RS01120 ENOG4105BZU Histidine kinase E3S99_RS01125 ENOG4105WH1 Two component transcriptional regulator luxr family E3S99_RS01150 ENOG4107VRP DNA repair exonuclease E3S99_RS01180 ENOG4105K59 histidine triad (HIT) protein E3S99_RS01215 ENOG4105C1Q protoporphyrinogen oxidase E3S99_RS01375 ENOG4105E09 nadh pyrophosphatase E3S99_RS01400 ENOG4105CV8 reductase E3S99_RS01410 ENOG4106A8V Protein CrcB homolog E3S99_RS01420 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) E3S99_RS01455 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis E3S99_RS01475 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) E3S99_RS01480 ENOG4108R6K riboflavin synthase, subunit alpha E3S99_RS01505 ENOG4105E8V Alpha Beta Hydrolase Fold protein E3S99_RS01520 ENOG4105N5T Radical SAM Protein E3S99_RS01525 ENOG410605W Major Facilitator E3S99_RS01545 ENOG4105CBX hi0933 family E3S99_RS01575 ENOG4108V15 phosphotransferase enzyme family E3S99_RS01585 ENOG4105C8F Beta-lactamase domain protein E3S99_RS01610 ENOG4108VDD TRNA binding domain protein E3S99_RS01640 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase E3S99_RS01650 ENOG4105ETE Transcriptional regulator (LacI family E3S99_RS01655 ENOG4105DGU Histone deacetylase E3S99_RS01660 ENOG4105F1V Acetoin utilization protein E3S99_RS01700 ENOG4105C0H protease E3S99_RS01705 ENOG4105F6E Acyl-transferase E3S99_RS01725 ENOG4108JQ1 Dehydrogenase E3S99_RS01730 ENOG4105C5R Aminotransferase E3S99_RS01735 ENOG4108X3M OsmC Ohr family protein E3S99_RS01740 ENOG4108QXE glycerophosphoryl diester phosphodiesterase E3S99_RS01780 ENOG4105EJ9 Membrane E3S99_RS01835 ENOG4105SFS phosphoesterase RecJ domain protein E3S99_RS01845 ENOG4105C6K Malic enzyme E3S99_RS01870 ENOG4105C85 amino acid E3S99_RS01875 ENOG4105BZN citrate synthase E3S99_RS01885 ENOG4105DPZ Two component transcriptional regulator (Winged helix family E3S99_RS01890 ENOG4105BZU Histidine kinase E3S99_RS01900 ENOG4105C2M dna polymerase I E3S99_RS01905 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) E3S99_RS01945 ENOG4108IQI permease E3S99_RS01965 ENOG4105U6W MutT NUDIX family protein E3S99_RS02015 ENOG4105D52 delta-aminolevulinic acid dehydratase E3S99_RS02035 ENOG4108R3E Dna-3-methyladenine glycosylase i E3S99_RS02045 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase E3S99_RS02050 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) E3S99_RS02095 ENOG4105X36 (ribosomal) protein E3S99_RS02135 ENOG4105VIE preprotein translocase, subunit YajC E3S99_RS02140 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) E3S99_RS02145 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) E3S99_RS02190 ENOG4105CUZ uba thif-type nad fad binding protein E3S99_RS02195 ENOG4105D1H recombination factor protein RarA E3S99_RS02215 ENOG4105DEN Luciferase family E3S99_RS02220 ENOG4105C3J Cysteine desulfurase E3S99_RS02235 ENOG4105C7H Helicase, RecD TraA family E3S99_RS02265 ENOG4105XYU peptidase (U32 family) E3S99_RS02270 ENOG4105CFP Peptidase U32 E3S99_RS02285 ENOG4105P4J Allophanate hydrolase, subunit 1 E3S99_RS02295 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein E3S99_RS02300 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase E3S99_RS02310 ENOG4105C5A transporter E3S99_RS02335 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase E3S99_RS02340 ENOG4105CQW ribosome biogenesis GTPase YqeH E3S99_RS02350 ENOG410812S Rna-binding protein E3S99_RS02360 ENOG4108WF2 Metal Dependent Phosphohydrolase E3S99_RS02365 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) E3S99_RS02370 ENOG4105DXX methyltransferase E3S99_RS02375 ENOG4105BZM domain protein E3S99_RS02380 ENOG4108UK2 deaminase E3S99_RS02385 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 E3S99_RS02390 ENOG4105TQK DNA polymerase iii, delta' subunit E3S99_RS02405 ENOG4105CSA Coproporphyrinogen iii oxidase E3S99_RS02435 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) E3S99_RS02440 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) E3S99_RS02450 ENOG4105F7J membrane-bound serine protease E3S99_RS02465 ENOG4105C9A Phoh family E3S99_RS02480 ENOG4105KG3 cytidine deaminase E3S99_RS02515 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) E3S99_RS02530 ENOG4105C1J atp-dependent rna helicase E3S99_RS02540 ENOG4105FDK ABC transporter E3S99_RS02545 ENOG4105FAV ABC, transporter E3S99_RS02550 ENOG4105N80 Ferric uptake regulator, Fur family E3S99_RS02560 ENOG4107RF6 penicillin-binding protein E3S99_RS02570 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase E3S99_RS02595 ENOG4105C5X domain protein E3S99_RS02605 ENOG4105D7Q type ii secretion system E3S99_RS02610 ENOG4106855 Competence protein E3S99_RS02655 ENOG4105WZW rhodanese family E3S99_RS02660 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) E3S99_RS02675 ENOG4105DC7 peptidase M24 E3S99_RS02690 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase E3S99_RS02695 ENOG4108ZSR alkaline shock protein E3S99_RS02725 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) E3S99_RS02740 ENOG4105CPP Dehydrogenase, E1 component E3S99_RS02745 ENOG4105C7S Dehydrogenase E3S99_RS02755 ENOG4108QEG Membrane E3S99_RS02765 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) E3S99_RS02770 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) E3S99_RS02800 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase E3S99_RS02810 ENOG4105II7 pyrroline-5-carboxylate reductase E3S99_RS02815 ENOG4105PDP Short chain dehydrogenase E3S99_RS02825 ENOG4105CPC Aldo Keto reductase E3S99_RS02830 ENOG4108YZ4 nudix hydrolase E3S99_RS02835 ENOG4105I3K Ferric uptake regulator, Fur family E3S99_RS02840 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) E3S99_RS02860 ENOG4105FE9 pseudouridine synthase E3S99_RS02865 ENOG4105CK6 Two component transcriptional regulator (Winged helix family E3S99_RS02870 ENOG4105BZU Histidine kinase E3S99_RS02905 ENOG4105C9U ATP-dependent DNA helicase RecQ E3S99_RS02910 ENOG4106BU8 elastin-binding protein ebpS E3S99_RS02920 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase E3S99_RS02925 ENOG4105HDK L-asparaginase E3S99_RS02945 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) E3S99_RS02960 ENOG4105K70 DNA-binding protein E3S99_RS02975 ENOG4105EAH synthase E3S99_RS03025 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase E3S99_RS03030 ENOG4105CPK Glycosyl transferase (Group 1 E3S99_RS03060 ENOG4105CSM endonuclease III E3S99_RS03070 ENOG4105BZ4 penicillin-binding protein E3S99_RS03100 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) E3S99_RS03115 ENOG410890F Dynamin family E3S99_RS03135 ENOG4107R7I amino acid E3S99_RS03195 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) E3S99_RS03205 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) E3S99_RS03240 ENOG410841Q phosphoesterase PA-phosphatase related protein E3S99_RS03300 ENOG4107T89 von Willebrand factor, type A E3S99_RS03345 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) E3S99_RS03350 ENOG4108XFP Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) E3S99_RS03375 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) E3S99_RS03380 ENOG4105CFH Aspartokinase E3S99_RS03385 ENOG4105C5H ABC transporter E3S99_RS03400 ENOG4105C8U phosphate abc transporter E3S99_RS03405 ENOG4105E2Z phosphate ABC transporter (Permease E3S99_RS03415 ENOG4108UTW Plays a role in the regulation of phosphate uptake E3S99_RS03420 ENOG4105DPN Oligoendopeptidase f E3S99_RS03430 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component E3S99_RS03435 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component E3S99_RS03455 ENOG4108KP7 hydrolase E3S99_RS03460 ENOG4108TV1 Catalyzes the incorporation of amino acid(s) into the interchain peptide bridge of peptidoglycan, using aminoacyl-tRNA as amino acid donor (By similarity) E3S99_RS03465 ENOG4108RMH femAB family E3S99_RS03495 ENOG4105DDQ anthranilate synthase E3S99_RS03500 ENOG4105CRQ synthase (Component I) E3S99_RS03505 ENOG4105DER m42 family E3S99_RS03515 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) E3S99_RS03525 ENOG4108RCF TRANSCRIPTIONal E3S99_RS03530 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) E3S99_RS03560 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E3S99_RS03565 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E3S99_RS03585 ENOG4108I0Z Aconitate hydratase E3S99_RS03590 ENOG4105C94 Transporter E3S99_RS03645 ENOG4105K4I Scp-like extracellular E3S99_RS03675 ENOG4108IQI permease E3S99_RS03700 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) E3S99_RS03705 ENOG4105D6E homoserine dehydrogenase E3S99_RS03710 ENOG4105CFH Aspartokinase E3S99_RS03735 ENOG4108S01 response regulator E3S99_RS03750 ENOG4108M15 ABC transporter E3S99_RS03790 ENOG4105IG6 Phage terminase, large subunit E3S99_RS03895 ENOG4105C5F glutamine synthetase E3S99_RS03900 ENOG4105KV4 Transcriptional regulator E3S99_RS03905 ENOG4105CXI aluminum resistance protein E3S99_RS03910 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) E3S99_RS03915 ENOG4108V06 Glutathione peroxidase E3S99_RS03920 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) E3S99_RS03945 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) E3S99_RS03950 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator E3S99_RS03985 ENOG4105DQU oxidoreductase, subunit beta E3S99_RS03990 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein E3S99_RS03995 ENOG4105D48 metallophosphoesterase E3S99_RS04015 ENOG4105CEV competence damage-inducible protein E3S99_RS04020 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase E3S99_RS04035 ENOG4108RKS Short-chain dehydrogenase reductase Sdr E3S99_RS04050 ENOG4105FDP GntR family transcriptional regulator E3S99_RS04055 ENOG4105CNU cell division protein FtsK E3S99_RS04075 ENOG4105DTN riboflavin biosynthesis protein ribF E3S99_RS04100 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination E3S99_RS04105 ENOG4105CHV Transcription elongation factor NusA E3S99_RS04130 ENOG4105KNE Phosphatidate cytidylyltransferase E3S99_RS04135 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) E3S99_RS04195 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) E3S99_RS04200 ENOG4105C79 DNA protecting protein DprA E3S99_RS04205 ENOG4108RMH femAB family E3S99_RS04215 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha E3S99_RS04230 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) E3S99_RS04270 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) E3S99_RS04275 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) E3S99_RS04290 ENOG4105CHR reductase E3S99_RS04295 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase E3S99_RS04310 ENOG4105CB5 ATP-dependent DNA helicase recG E3S99_RS04320 ENOG4108ZAA Alkaline-shock protein E3S99_RS04335 ENOG4105DJV ribulose-phosphate 3-epimerase E3S99_RS04340 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) E3S99_RS04350 ENOG4108ZF3 Phosphatase E3S99_RS04360 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B E3S99_RS04375 ENOG4105YB8 TM2 domain containing protein E3S99_RS04385 ENOG4105C25 Primosomal protein n' E3S99_RS04390 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase E3S99_RS04405 ENOG4105F23 Fibronectin-binding protein E3S99_RS04420 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) E3S99_RS04435 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain E3S99_RS04440 ENOG4105CD3 dihydroorotase E3S99_RS04460 ENOG4105C34 Pseudouridine synthase E3S99_RS04470 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase E3S99_RS04490 ENOG41067XK integral membrane protein E3S99_RS04500 ENOG4105DFA alanine racemase domain protein E3S99_RS04510 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) E3S99_RS04515 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) E3S99_RS04535 ENOG4105CJN penicillin-binding protein E3S99_RS04540 ENOG41068DC Essential cell division protein (By similarity) E3S99_RS04600 ENOG4105CSX c4-dicarboxylate anaerobic carrier E3S99_RS04610 ENOG4105DBV ornithine carbamoyltransferase E3S99_RS04640 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity E3S99_RS04700 ENOG4105E33 succinate dehydrogenase E3S99_RS04710 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit E3S99_RS04735 ENOG4105DCG PHP domain protein E3S99_RS04765 ENOG4108RWN rrna methyltransferase E3S99_RS04780 ENOG4105KFN sortase, SrtB family E3S99_RS04835 ENOG4106H78 methyltransferase E3S99_RS04850 ENOG4107VXM glycerophosphoryl diester phosphodiesterase E3S99_RS04880 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) E3S99_RS04885 ENOG4105CNI cell division protein FtsW E3S99_RS04905 ENOG4105CI3 gtp-binding protein typa E3S99_RS04915 ENOG4105ECY inositol monophosphatase E3S99_RS04940 ENOG4107RUE extracellular solute-binding protein family 1 E3S99_RS04945 ENOG4105D38 putrescine abc transporter E3S99_RS04950 ENOG4105F38 ABC transporter, permease E3S99_RS04970 ENOG4107QN2 dihydrolipoyl dehydrogenase E3S99_RS04975 ENOG4105C7S Dehydrogenase E3S99_RS04980 ENOG4105CPP Dehydrogenase, E1 component E3S99_RS04995 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) E3S99_RS05015 ENOG4107ZYR domain protein E3S99_RS05030 ENOG41067VN Glutaredoxin E3S99_RS05040 ENOG4105KRI phosphocarrier protein (HPr E3S99_RS05050 ENOG4105DR4 Methyltransferase E3S99_RS05070 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein E3S99_RS05075 ENOG4108JJB ABC transporter E3S99_RS05080 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) E3S99_RS05095 ENOG4108V3E phosphoribosylglycinamide formyltransferase E3S99_RS05105 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase E3S99_RS05120 ENOG4105VR9 phosphoribosylformylglycinamidine synthase E3S99_RS05130 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit E3S99_RS05135 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) E3S99_RS05180 ENOG4108KGH TRANSCRIPTIONal E3S99_RS05190 ENOG41082BV acetyltransferase E3S99_RS05210 ENOG4108TGC Acyltransferase E3S99_RS05215 ENOG4105CHM Aminotransferase E3S99_RS05235 ENOG4108IPT Naphthoate synthase E3S99_RS05250 ENOG4105E4F Isochorismate synthase E3S99_RS05260 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase E3S99_RS05265 ENOG41080E2 ribosomal-protein-alanine acetyltransferase E3S99_RS05270 ENOG4105YB8 TM2 domain containing protein E3S99_RS05280 ENOG4108HUF Transporter E3S99_RS05295 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) E3S99_RS05345 ENOG4105XVF Competence transcription factor E3S99_RS05360 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic E3S99_RS05375 ENOG4107TS3 membrane protein, TerC E3S99_RS05415 ENOG4105BZG amino acid carrier protein E3S99_RS05420 ENOG4105C02 permease E3S99_RS05435 ENOG4105CJW magnesium transporter E3S99_RS05440 ENOG4105EMS pseudouridine synthase E3S99_RS05455 ENOG4106EFP UPF0738 protein E3S99_RS05465 ENOG4108Z18 K06886 hemoglobin E3S99_RS05470 ENOG4105T58 Dithiol-disulfide isomerase E3S99_RS05475 ENOG4105DPN Oligoendopeptidase f E3S99_RS05490 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) E3S99_RS05495 ENOG4105C31 Tryptophanyl-tRNA synthetase E3S99_RS05500 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component E3S99_RS05510 ENOG4108JQ7 (ABC) transporter E3S99_RS05520 ENOG4105DEF Extracellular solute-binding protein, family 5 E3S99_RS05530 ENOG4108JQ7 (ABC) transporter E3S99_RS05540 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component E3S99_RS05545 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component E3S99_RS05555 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) E3S99_RS05575 ENOG4105KIS phospholipid-binding protein E3S99_RS05585 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit E3S99_RS05590 ENOG4105EXC Acyl-transferase E3S99_RS05600 ENOG4108KP7 hydrolase E3S99_RS05620 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation E3S99_RS05660 ENOG4107VXM glycerophosphoryl diester phosphodiesterase E3S99_RS05665 ENOG4105D82 Glutamate dehydrogenase E3S99_RS05670 ENOG4105C8Y Acetylornithine aminotransferase E3S99_RS05675 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase E3S99_RS05680 ENOG41060GV RNA binding s1 domain protein E3S99_RS05735 ENOG4105KA0 thioesterase Superfamily protein E3S99_RS05745 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) E3S99_RS05755 ENOG4108YX9 iron--sulfur cluster insertion protein erpA E3S99_RS05775 ENOG41083MR nifu domain-containing protein E3S99_RS05780 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD E3S99_RS05790 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein E3S99_RS05830 ENOG4105MMD transcriptional regulator E3S99_RS05850 ENOG4105I3N Conserved Protein E3S99_RS05880 ENOG4108UNV SUF system FeS assembly protein, NifU family E3S99_RS05885 ENOG4105C9B Cysteine desulfurase E3S99_RS05890 ENOG4105JRK feS assembly protein SufD E3S99_RS05895 ENOG4105C3K feS assembly ATPase SufC E3S99_RS05910 ENOG4105D01 (LipO)protein E3S99_RS05915 ENOG4108UMI ABC transporter, permease E3S99_RS05920 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) E3S99_RS05935 ENOG4108XI2 Domain of unknown function (DUF1963) E3S99_RS05950 ENOG41080E8 Transcriptional regulator, Spx MgsR family E3S99_RS05955 ENOG4105SZ6 Thioredoxin E3S99_RS05980 ENOG4108ZUB Lysine exporter protein (Lyse ygga) E3S99_RS05985 ENOG4105CVJ phosphoglycerate mutase E3S99_RS06025 ENOG4105VEQ Cold shock protein E3S99_RS06090 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) E3S99_RS06100 ENOG4105XZU Preprotein translocase, subunit SecG E3S99_RS06130 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase E3S99_RS06150 ENOG4105C6K Malic enzyme E3S99_RS06165 ENOG4105CHW UPF0052 protein E3S99_RS06175 ENOG4105C3M thioredoxin reductase E3S99_RS06185 ENOG4108S4C acetyltransferase E3S99_RS06205 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) E3S99_RS06220 ENOG41068JE domain protein E3S99_RS06245 ENOG41081UC Inherit from COG: Competence protein E3S99_RS06260 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein E3S99_RS06265 ENOG4105ESV Glycosyl transferase, family 4 E3S99_RS06325 ENOG4108IPW abc transporter atp-binding protein E3S99_RS06330 ENOG4105CM4 permease protein E3S99_RS06335 ENOG4105DHS permease protein E3S99_RS06340 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) E3S99_RS06345 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) E3S99_RS06365 ENOG4105DUX Transporter E3S99_RS06380 ENOG4108ZIE 5 nucleotidase deoxy cytosolic type C E3S99_RS06390 ENOG4105E90 ABC transporter E3S99_RS06395 ENOG4108IJ8 ABC transporter E3S99_RS06400 ENOG4105C9U ATP-dependent DNA helicase RecQ E3S99_RS06405 ENOG4105C5H ABC transporter E3S99_RS06435 ENOG4105CRQ synthase (Component I) E3S99_RS06440 ENOG4105DDQ anthranilate synthase E3S99_RS06450 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase E3S99_RS06455 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) E3S99_RS06485 ENOG4105CKK Glycosyl transferase, family 2 E3S99_RS06495 ENOG4105C37 (CBS) domain E3S99_RS06500 ENOG4105CE4 GlcNAc 6-P deacetylase E3S99_RS06505 ENOG4105DM4 PTS System E3S99_RS06510 ENOG4105DE4 1-phosphofructokinase E3S99_RS06515 ENOG4105E98 transcriptional regulator DeoR family E3S99_RS06520 ENOG4108Z66 YbaK ebsC protein E3S99_RS06550 ENOG4105CVP deoxyribo-dipyrimidine photolyase E3S99_RS06555 ENOG4107QPK )-transporter E3S99_RS06565 ENOG4107QM2 Aldo Keto reductase E3S99_RS06570 ENOG4105CKI cobalamin synthesis protein E3S99_RS06575 ENOG41083AI transcriptional regulator), MarR family E3S99_RS06580 ENOG4108JJ8 (ABC) transporter E3S99_RS06585 ENOG4108JJ9 ABC, transporter E3S99_RS06605 ENOG4108URH decarboxylase E3S99_RS06610 ENOG4108YYQ gCN5-related N-acetyltransferase E3S99_RS06635 ENOG4105SXS Protein of unknown function (DUF456) E3S99_RS06640 ENOG4105S8Q sugar efflux transporter E3S99_RS06675 ENOG4105ID8 Transcriptional regulator, ARAC family E3S99_RS06685 ENOG4105VRS hydrolase family 18 E3S99_RS06690 ENOG4105CJ3 phosphate transporter E3S99_RS06695 ENOG4107GRR phosphate transport regulator E3S99_RS06705 ENOG4105C19 ABC transporter E3S99_RS06740 ENOG4108K88 Membrane E3S99_RS06750 ENOG4105VDH Dihydroxyacetone kinase E3S99_RS06760 ENOG4105CMT Dihydroxyacetone kinase E3S99_RS06765 ENOG4105EHG Permease protein E3S99_RS06770 ENOG4105DQ5 transport system permease protein E3S99_RS06775 ENOG4105E0A ABC, transporter E3S99_RS06780 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) E3S99_RS06795 ENOG4105BZ1 (ABC) transporter E3S99_RS06805 ENOG4107YSK Glycerol-3-phosphate cytidylyltransferase E3S99_RS06830 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family E3S99_RS06840 ENOG4107R5H iron (metal) dependent repressor, dtxr family E3S99_RS06845 ENOG4105DIK (ABC) transporter E3S99_RS06850 ENOG4105CC5 ABC transporter E3S99_RS06855 ENOG4105DSE periplasmic solute binding protein E3S99_RS06860 ENOG4105EEQ Na H antiporter E3S99_RS06900 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) E3S99_RS06940 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) E3S99_RS06950 ENOG4105EHG Permease protein E3S99_RS06955 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) E3S99_RS06985 ENOG4108XFG YwhD family E3S99_RS06990 ENOG4105DCI Phosphohydrolase E3S99_RS07000 ENOG4108WS4 fmn reductase E3S99_RS07005 ENOG4105CPC Aldo Keto reductase E3S99_RS07050 ENOG4107QN2 dihydrolipoyl dehydrogenase E3S99_RS07070 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) E3S99_RS07075 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) E3S99_RS07080 ENOG4108IJ2 phosphate acetyltransferase E3S99_RS07120 ENOG4105DWF phosphomethylpyrimidine kinase E3S99_RS07180 ENOG4107YEI lmbE family E3S99_RS07200 ENOG4105DUY Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein E3S99_RS07205 ENOG4105DUY Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein E3S99_RS07220 ENOG410667J hydrolase E3S99_RS07225 ENOG4108Z6B deaminase E3S99_RS07235 ENOG4105ZMH deoxynucleoside kinase E3S99_RS07265 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) E3S99_RS07300 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) E3S99_RS07310 ENOG4107Y49 methyltransferase E3S99_RS07340 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) E3S99_RS07345 ENOG410683Z Preprotein translocase SecE subunit E3S99_RS07365 ENOG4105C2N RNA methyltransferase TrmH family group 3 E3S99_RS07370 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) E3S99_RS07390 ENOG4105CTP PilT protein domain protein E3S99_RS07395 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) E3S99_RS07410 ENOG4108Z0C Uvrb UvrC protein E3S99_RS07420 ENOG4105D9N nucleoside E3S99_RS07435 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family E3S99_RS07535 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase E3S99_RS07550 ENOG4105C6T cysteine synthase E3S99_RS07560 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) E3S99_RS07565 ENOG4108UGV hypoxanthine phosphoribosyltransferase E3S99_RS07575 ENOG41060GV RNA binding s1 domain protein E3S99_RS07585 ENOG41082I2 s4 domain protein E3S99_RS07590 ENOG4108IY2 MazG family E3S99_RS07615 ENOG4105C5T Phosphoribosyl pyrophosphate synthase E3S99_RS07635 ENOG4105KME endoribonuclease L-psp E3S99_RS07640 ENOG4105DFT pur operon repressor E3S99_RS07650 ENOG4105W42 Veg protein E3S99_RS07660 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) E3S99_RS07665 ENOG4105F8V Hydrolase, tatD family E3S99_RS07675 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) E3S99_RS07685 ENOG41060K3 Methyltransferase E3S99_RS07695 ENOG4105MA4 psp1 domain protein E3S99_RS07700 ENOG4105FA2 dna polymerase iii E3S99_RS07705 ENOG4105X0R protein from nitrogen regulatory protein P-II E3S99_RS07715 ENOG4105CXN decarboxylase E3S99_RS07745 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) E3S99_RS07750 ENOG4105C6E dna polymerase iii E3S99_RS07770 ENOG4107414 GntR family transcriptional regulator E3S99_RS07775 ENOG4105CG3 alpha amylase, catalytic region E3S99_RS07780 ENOG4105C5Y PTS System E3S99_RS07790 ENOG4105BZ8 glutamate synthase E3S99_RS07795 ENOG4105CBC glutamate synthase E3S99_RS07800 ENOG4105C5Q Transcriptional regulator E3S99_RS07835 ENOG4105D01 (LipO)protein E3S99_RS07840 ENOG4108UMI ABC transporter, permease E3S99_RS07850 ENOG4105C28 cystathionine E3S99_RS07860 ENOG4105C8J )-transporter E3S99_RS07885 ENOG4105GPN Uncharacterized conserved protein (DUF2294) E3S99_RS07895 ENOG4108TWJ NADH dehydrogenase subunit 5 E3S99_RS07920 ENOG4105CKI cobalamin synthesis protein E3S99_RS08035 ENOG4105KA3 membrAne E3S99_RS08040 ENOG4105EWC Purine nucleoside phosphorylase E3S99_RS08045 ENOG4105G7B Protein of unknown function (DUF2992) E3S99_RS08115 ENOG4105C2W permease E3S99_RS08145 ENOG4107R6U sodium dicarboxylate symporter E3S99_RS08160 ENOG4108JU3 Alkyl hydroperoxide reductase E3S99_RS08235 ENOG4108UUM single-stranded DNA-binding protein E3S99_RS08250 ENOG4105C3G gtp-binding protein E3S99_RS08255 ENOG4105VDK protein, conserved in bacteria E3S99_RS08260 ENOG4105D8X mechanosensitive ion channel E3S99_RS08265 ENOG4105FA0 parb-like partition protein E3S99_RS08270 ENOG4105C28 cystathionine E3S99_RS08275 ENOG4105C28 cystathionine E3S99_RS08310 ENOG4105CJ1 ABC, transporter E3S99_RS08320 ENOG4105VZ8 Transcriptional regulator E3S99_RS08330 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) E3S99_RS08340 ENOG4107SJW iron permease, FTR1 E3S99_RS08345 ENOG4105DBE peroxidase E3S99_RS08350 ENOG410650H (LipO)protein E3S99_RS08360 ENOG4105HMI Membrane E3S99_RS08365 ENOG4107V0Z fmn reductase E3S99_RS08380 ENOG4105CXY transporter E3S99_RS08400 ENOG4105ETD TRANSCRIPTIONal E3S99_RS08405 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia E3S99_RS08415 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC E3S99_RS08440 ENOG4105DEN Luciferase family E3S99_RS08465 ENOG4105DWD nucleoside recognition domain protein E3S99_RS08475 ENOG4106KNT transcriptional regulator E3S99_RS08480 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) E3S99_RS08490 ENOG4107RJ1 sodium solute E3S99_RS08520 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) E3S99_RS08525 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) E3S99_RS08530 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family E3S99_RS08590 ENOG4108Q9H CobQ/CobB/MinD/ParA nucleotide binding domain E3S99_RS08615 ENOG4108U7W acetyltransferase E3S99_RS08620 ENOG41075D4 Aminoglycoside 6-adenylyltransferase E3S99_RS08625 ENOG4105DMQ Methyltransferase E3S99_RS08640 ENOG4105MKU Transcriptional regulator E3S99_RS08660 ENOG4108BUD transposase E3S99_RS08735 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) E3S99_RS08875 ENOG4105EC2 ftsk spoIIIe E3S99_RS08885 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) E3S99_RS08905 ENOG4105VRS hydrolase family 18 E3S99_RS08935 ENOG4108M15 ABC transporter E3S99_RS08940 ENOG41061JJ Peptidase family M23 E3S99_RS08965 ENOG4105EV1 Ribose uptake protein RbsU E3S99_RS08985 ENOG4105DVA methyltransferase E3S99_RS08990 ENOG4105CS2 ec 3.2.1.21 E3S99_RS08995 ENOG4105CI1 PTS System E3S99_RS09035 ENOG4107RZX Teichoic acid biosynthesis protein E3S99_RS09040 ENOG4105EJJ Dehydrogenase E3S99_RS09050 ENOG4107SJB teichoic acid biosynthesis E3S99_RS09055 ENOG4107RZX Teichoic acid biosynthesis protein E3S99_RS09060 ENOG4105EJJ Dehydrogenase E3S99_RS09065 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) E3S99_RS09070 ENOG4105CPQ Dehydrogenase E3S99_RS09080 ENOG4105CPQ Dehydrogenase E3S99_RS09085 ENOG4105DT3 PTS system, galactitol-specific IIc component E3S99_RS09090 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) E3S99_RS09105 ENOG4105DU0 nucleoside hydrolase E3S99_RS09110 ENOG4105CI1 PTS System E3S99_RS09135 ENOG4105K78 MarR family Transcriptional regulator E3S99_RS09140 ENOG4107RRN ABC transporter substrate-binding protein E3S99_RS09145 ENOG4105ENX hydrolase E3S99_RS09170 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) E3S99_RS09175 ENOG4105CEY Amp-dependent synthetase and ligase E3S99_RS09180 ENOG4105C1G acyl-Coa dehydrogenase E3S99_RS09185 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase E3S99_RS09190 ENOG4105CHU acetyl-coa acetyltransferase E3S99_RS09230 ENOG4105C2F Histidine kinase E3S99_RS09235 ENOG4107VQW regulatoR E3S99_RS09240 ENOG4105CXY transporter E3S99_RS09245 ENOG4108WWS isoprenylcysteine carboxyl methyltransferase E3S99_RS09255 ENOG4105CK5 oxidoreductase E3S99_RS09265 ENOG4105EG2 ABC transporter, permease E3S99_RS09300 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) E3S99_RS09310 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component E3S99_RS09315 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component E3S99_RS09340 ENOG4105QEK Transcriptional regulator E3S99_RS09370 ENOG4107RA9 decarboxylase E3S99_RS09375 ENOG4105D3W isochorismatase E3S99_RS09380 ENOG4105CWM branched-chain amino acid transport system II carrier protein E3S99_RS09390 ENOG4105C8Y Acetylornithine aminotransferase E3S99_RS09430 ENOG4105C1G acyl-Coa dehydrogenase E3S99_RS09460 ENOG4105PGM cation diffusion facilitator family transporter E3S99_RS09465 ENOG4105C26 Dehydrogenase E3S99_RS09470 ENOG4105WD1 Membrane E3S99_RS09480 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase E3S99_RS09495 ENOG4105D3Q Sugar transferase E3S99_RS09525 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase E3S99_RS09535 ENOG4105C5E polysaccharide biosynthesis protein E3S99_RS09555 ENOG4105HTX biosynthesis protein E3S99_RS09560 ENOG4108EKI Dehydrogenase E3S99_RS09570 ENOG4105CGH 5'-nucleotidase E3S99_RS09605 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) E3S99_RS09610 ENOG4108J8C transporter major facilitator family protein E3S99_RS09615 ENOG4105D3A purine nucleoside phosphorylase DeoD-type E3S99_RS09645 ENOG4105CPK Glycosyl transferase (Group 1 E3S99_RS09655 ENOG4108IAJ Nad-dependent epimerase dehydratase E3S99_RS09665 ENOG4105CHR reductase E3S99_RS09685 ENOG41067FT ParB-like nuclease domain E3S99_RS09690 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) E3S99_RS09700 ENOG4105DUU IucA IucC family protein E3S99_RS09705 ENOG4105DBM Siderophore biosynthesis protein E3S99_RS09710 ENOG4105C6X Major Facilitator E3S99_RS09715 ENOG4105DJU Siderophore biosynthesis protein E3S99_RS09720 ENOG4105CIF Ornithine Cyclodeaminase E3S99_RS09730 ENOG4108MES Periplasmic binding protein E3S99_RS09735 ENOG4105DQ5 transport system permease protein E3S99_RS09740 ENOG4108IHU transport system permease protein E3S99_RS09770 ENOG4107Y9U Membrane E3S99_RS09775 ENOG4105CCI Myosin-Cross-Reactive Antigen E3S99_RS09785 ENOG4105C57 major facilitator superfamily E3S99_RS09805 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C E3S99_RS09815 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) E3S99_RS09825 ENOG4105ENX hydrolase E3S99_RS09840 ENOG4108WS4 fmn reductase E3S99_RS09885 ENOG4107TJV N-acetylglutamate semialdehyde dehydrogenase E3S99_RS09890 ENOG4108KB0 deacetylase E3S99_RS09895 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) E3S99_RS09900 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) E3S99_RS09905 ENOG4105C12 Phosphoribosylglycinamide synthetase E3S99_RS09940 ENOG4108YM7 Gcn5-related n-acetyltransferase E3S99_RS09965 ENOG4105CGH 5'-nucleotidase E3S99_RS09970 ENOG4105Q2H domain protein E3S99_RS10005 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis E3S99_RS10010 ENOG4105CDU Replicative dna helicase E3S99_RS10020 ENOG4105BZR domain protein E3S99_RS10030 ENOG4105DWV Homoserine O-trans-acetylase E3S99_RS10055 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) E3S99_RS10060 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E3S99_RS10075 ENOG410848D S4 domain protein YaaA E3S99_RS10080 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) E3S99_RS10115 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) E3S99_RS10155 ENOG4105C19 ABC transporter E3S99_RS10170 ENOG4105D9G High-affinity E3S99_RS10180 ENOG4105FR1 rard protein E3S99_RS10185 ENOG4107QPK )-transporter E3S99_RS10245 ENOG4105CIH Imidazole acetol-phosphate transaminase E3S99_RS10270 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase E3S99_RS10280 ENOG4105J1V Triacylglycerol lipase E3S99_RS10300 ENOG4107QJZ Glycosyl transferase, family 2 E3S99_RS10305 ENOG4108IG5 Transcriptional regulator E3S99_RS10330 ENOG4108F19 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) E3S99_RS10335 ENOG4107XC4 flavin reductase domain protein, FMN-binding E3S99_RS10360 ENOG4105EW6 flavin reductase domain protein, FMN-binding E3S99_RS10365 ENOG4106432 Mediates binding to human platelets, possibly through a receptor-ligand interaction. Probably associated with virulence in endovascular infection (By similarity) E3S99_RS10370 ENOG4106YAG Part of the accessory SecA2 SecY2 system specifically required for export of E3S99_RS10375 ENOG4108XJK accessory Sec system protein Asp1 E3S99_RS10380 ENOG41089G2 accessory Sec system protein Asp2 E3S99_RS10385 ENOG4106E62 Accessory Sec system protein Asp3 E3S99_RS10410 ENOG4105WQI isochorismatase E3S99_RS10415 ENOG4108S4A n-acetylmuramoyl-l-alanine amidase E3S99_RS10425 ENOG4105DG6 mannose-6-phosphate isomerase E3S99_RS10430 ENOG4105DM4 PTS System E3S99_RS10455 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) E3S99_RS10465 ENOG4105CEU Arginine dihydrolase E3S99_RS10470 ENOG4105DBV ornithine carbamoyltransferase E3S99_RS10480 ENOG4105C5B carbamate kinase E3S99_RS10490 ENOG4105T6C Cell surface-associated protein implicated in virulence by promoting bacterial attachment to both alpha- and beta-chains of human fibrinogen and inducing the formation of bacterial clumps E3S99_RS10490 ENOG4105T6C Cell surface-associated protein implicated in virulence by promoting bacterial attachment to both alpha- and beta-chains of human fibrinogen and inducing the formation of bacterial clumps E3S99_RS10500 ENOG4108U05 Transcriptional regulator E3S99_RS10510 ENOG4105G6Z alkaline phosphatase E3S99_RS10560 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) E3S99_RS10565 ENOG4108Z73 Siroheme synthase E3S99_RS10575 ENOG4105D4T Citrate transporter E3S99_RS10580 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase E3S99_RS10585 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) E3S99_RS10600 ENOG4105C94 Transporter E3S99_RS10605 ENOG4105TRT Transcriptional regulator E3S99_RS10615 ENOG4105C26 Dehydrogenase E3S99_RS10635 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) E3S99_RS10645 ENOG4105DWT malate dehydrogenase (quinone) E3S99_RS10660 ENOG4108JPW Aminotransferase E3S99_RS10665 ENOG4105CUB amino acid E3S99_RS10675 ENOG4107FQX Alpha-acetolactate decarboxylase E3S99_RS10680 ENOG4108NKJ Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) E3S99_RS10730 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) E3S99_RS10735 ENOG4105FGM Fructosamine kinase E3S99_RS10755 ENOG4107T5J pyridine nucleotide-disulfide oxidoreductase E3S99_RS10770 ENOG4108SXP alpha beta E3S99_RS10780 ENOG4105CHR reductase E3S99_RS10835 ENOG4105KY5 gCN5-related N-acetyltransferase E3S99_RS10840 ENOG4105EXC Acyl-transferase E3S99_RS10890 ENOG4105C59 p-type ATPase E3S99_RS10920 ENOG4105EYF MMPL domain protein E3S99_RS10945 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) E3S99_RS10950 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase E3S99_RS10960 ENOG41068JE domain protein E3S99_RS10970 ENOG4105CMU LysR family (Transcriptional regulator E3S99_RS11010 ENOG4108UZ3 Transporter E3S99_RS11030 ENOG4105EJQ L-serine dehydratase E3S99_RS11045 ENOG4108Z7F N-acetyltransferase E3S99_RS11050 ENOG4108Z6X (sortase) family E3S99_RS11055 ENOG4106KKU E3S99_RS11060 ENOG4108Z15 abc transporter atp-binding protein E3S99_RS11065 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) E3S99_RS11070 ENOG4105C5I Dehydrogenase E3S99_RS11080 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase E3S99_RS11090 ENOG41090MY MarR family Transcriptional regulator E3S99_RS11100 ENOG4105FBA Phospholipase Carboxylesterase E3S99_RS11120 ENOG4105CJ1 ABC, transporter E3S99_RS11130 ENOG4107T5V SNARE associated Golgi E3S99_RS11135 ENOG4105DJB Major Facilitator Superfamily E3S99_RS11145 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) E3S99_RS11160 ENOG4105G3Z GntR family transcriptional regulator E3S99_RS11165 ENOG4105CMG Carbohydrate kinase E3S99_RS11210 ENOG4105M6F mutator MutT protein E3S99_RS11305 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) E3S99_RS11310 ENOG4105CFC Transporter E3S99_RS11315 ENOG41061TZ Short-chain dehydrogenase reductase Sdr E3S99_RS11320 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein E3S99_RS11340 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein E3S99_RS11345 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component E3S99_RS11350 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component E3S99_RS11360 ENOG4108S9F abc transporter, atp-binding protein E3S99_RS11375 ENOG4105CBC glutamate synthase E3S99_RS11380 ENOG4105PQ4 (LipO)protein E3S99_RS11385 ENOG4105CN9 Peptidase m42 family protein E3S99_RS11390 ENOG41083J0 (ABC) transporter E3S99_RS11395 ENOG4105C4B ABC transporter, permease E3S99_RS11400 ENOG4105F27 Major Facilitator E3S99_RS11405 ENOG4105EBR Carboxylesterase E3S99_RS11415 ENOG4105CZ9 Domain of unknown function (DU1801) E3S99_RS11435 ENOG4105E90 ABC transporter E3S99_RS11445 ENOG4105R40 Glycine betaine carnitine choline E3S99_RS11450 ENOG4105C57 major facilitator superfamily E3S99_RS11455 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) E3S99_RS11470 ENOG4105C0X amino acid E3S99_RS11475 ENOG4105EEQ Na H antiporter E3S99_RS11480 ENOG4105C85 amino acid E3S99_RS11500 ENOG4105C2C drug resistance transporter, Bcr CflA E3S99_RS11510 ENOG4105BZW Glycerate kinase E3S99_RS11535 ENOG4105BZ1 (ABC) transporter E3S99_RS11545 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) E3S99_RS11550 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) E3S99_RS11560 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) E3S99_RS11620 ENOG4105EAB amino acid AbC transporter E3S99_RS11625 ENOG4105DRP amino acid AbC transporter E3S99_RS11630 ENOG4105CDA abc transporter atp-binding protein E3S99_RS11650 ENOG4105DSE periplasmic solute binding protein E3S99_RS11665 ENOG4105TMB Formate nitrite transporter E3S99_RS11670 ENOG4108XSB acetyltransferase, (GNAT) family E3S99_RS11680 ENOG4108IFG nitrite reductase, (NAD(P)H) E3S99_RS11685 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit E3S99_RS11690 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) E3S99_RS11700 ENOG4108IUE nitrate reductase beta subunit E3S99_RS11730 ENOG4107TXC Transcriptional regulator E3S99_RS11770 ENOG410606W general stress protein E3S99_RS11800 ENOG4105ECB domain protein E3S99_RS11850 ENOG4105DWT malate dehydrogenase (quinone) E3S99_RS11860 ENOG4105CJ1 ABC, transporter E3S99_RS11905 ENOG41062A4 Transcriptional regulator E3S99_RS11930 ENOG4105CW7 secretion protein, HlyD family E3S99_RS11935 ENOG4105C0R drug resistance transporter emrb qaca subfamily E3S99_RS11960 ENOG4105D7N magnesium and cobalt transport protein CorA E3S99_RS11970 ENOG4105D6U Sodium Glutamate Symporter E3S99_RS11980 ENOG4105KAF membrAne E3S99_RS11985 ENOG4108IUX (ABC) transporter E3S99_RS11990 ENOG4105RHA ABC transporter, permease E3S99_RS12010 ENOG4108RPX mosc domain containing protein E3S99_RS12030 ENOG4105C5Q Transcriptional regulator E3S99_RS12035 ENOG4105CGP Urocanate hydratase E3S99_RS12045 ENOG4105CH2 amidohydrolase E3S99_RS12050 ENOG4105CYX Short-chain dehydrogenase reductase Sdr E3S99_RS12070 ENOG4108Q3X Transcriptional regulator E3S99_RS12075 ENOG4105CI1 PTS System E3S99_RS12085 ENOG4105C09 Bile acid E3S99_RS12090 ENOG4107YBY Hydrolase E3S99_RS12165 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis E3S99_RS12195 ENOG4105DFD Na H antiporter E3S99_RS12270 ENOG4105FDT acyl-CoA dehydrogenase E3S99_RS12285 ENOG4107ZYJ bioY protein E3S99_RS12300 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein E3S99_RS12305 ENOG4105E0C molybdate abc transporter E3S99_RS12310 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) E3S99_RS12315 ENOG4105D06 uba thif-type nad fad binding protein E3S99_RS12320 ENOG4105EPU Molybdenum cofactor synthesis domain protein E3S99_RS12335 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein E3S99_RS12340 ENOG4108ZAF Molybdopterin E3S99_RS12420 ENOG4105CSC Glucose uptake protein E3S99_RS12440 ENOG4105C7N Xanthine uracil vitamin C permease E3S99_RS12555 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) E3S99_RS12560 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) E3S99_RS12625 ENOG4105CB5 ATP-dependent DNA helicase recG E3S99_RS12645 ENOG4107FQX Alpha-acetolactate decarboxylase E3S99_RS12660 ENOG4105CG5 Glycosyl transferase (Group 1 E3S99_RS12675 ENOG4106AM8 polysaccharide lyase family 8 E3S99_RS12685 ENOG4105VUF Transcriptional regulator E3S99_RS12730 ENOG4105VCP PTS System E3S99_RS12735 ENOG4105CK1 PTS System E3S99_RS12750 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein E3S99_RS12765 ENOG4105C94 Transporter E3S99_RS12790 ENOG4107SFI Major Facilitator superfamily E3S99_RS12800 ENOG4106M28 alanine racemase domain protein E3S99_RS12810 ENOG4108HUF Transporter E3S99_RS12815 ENOG4105DQ5 transport system permease protein E3S99_RS12820 ENOG4108U1V ABC transporter, permease E3S99_RS12825 ENOG4105DWD nucleoside recognition domain protein E3S99_RS12835 ENOG4107K5X Membrane-bound metal-dependent hydrolase E3S99_RS12845 ENOG4108UT2 hemolysin iii E3S99_RS12865 ENOG4105D1F ATP-binding protein E3S99_RS12925 ENOG4105C8B TIGR00159 family E3S99_RS12950 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein E3S99_RS12955 ENOG4105ETD TRANSCRIPTIONal E3S99_RS12965 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) E3S99_RS12970 ENOG4105DKW ABC transporter E3S99_RS12990 ENOG4105PGM cation diffusion facilitator family transporter E3S99_RS13005 ENOG4105DG6 mannose-6-phosphate isomerase E3S99_RS13025 ENOG4108RMU ferritin dps family protein E3S99_RS13030 ENOG4105D3A purine nucleoside phosphorylase DeoD-type E3S99_RS13095 ENOG4105D2N Aldolase E3S99_RS13115 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) E3S99_RS13135 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) E3S99_RS13140 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) E3S99_RS13165 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase E3S99_RS13255 ENOG4105DWF phosphomethylpyrimidine kinase E3S99_RS13280 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) E3S99_RS13285 ENOG4105VPX protein, conserved in bacteria E3S99_RS13310 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) E3S99_RS13320 ENOG4105EEX Two component transcriptional regulator (Winged helix family E3S99_RS13325 ENOG4105C08 Histidine kinase E3S99_RS13355 ENOG4105CKV Membrane E3S99_RS13385 ENOG4107SGM protein serine threonine phosphatase E3S99_RS13390 ENOG4105WN5 stage II sporulation protein E3S99_RS13460 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) E3S99_RS13480 ENOG4105C7K acetolactate synthase E3S99_RS13495 ENOG4105K8N protein family UPF0079, ATPase E3S99_RS13500 ENOG41072GX Peptidase M22 Glycoprotease E3S99_RS13505 ENOG410801F ribosomal-protein-alanine acetyltransferase E3S99_RS13515 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) E3S99_RS13525 ENOG4105C5H ABC transporter E3S99_RS13535 ENOG4105CUC YeeE YedE family protein E3S99_RS13545 ENOG4105BZU Histidine kinase E3S99_RS13570 ENOG4108WCX response regulator E3S99_RS13630 ENOG4105CZN Potassium uptake protein E3S99_RS13680 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) E3S99_RS13760 ENOG4108UUM single-stranded DNA-binding protein