locus-tag	class	description
E3S66_RS00020	COG0740	serine-type endopeptidase activity
E3S66_RS00070	COG0739	heme binding
E3S66_RS00120	COG5632	N-Acetylmuramoyl-L-alanine amidase
E3S66_RS00120	COG1388	LysM domain
E3S66_RS00185	COG1725	Transcriptional regulator
E3S66_RS00200	COG1131	(ABC) transporter
E3S66_RS00255	COG1012	belongs to the aldehyde dehydrogenase family
E3S66_RS00270	COG1335	isochorismatase
E3S66_RS00280	COG0471	metal ion transport
E3S66_RS00290	COG0077	Prephenate dehydratase
E3S66_RS00300	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E3S66_RS00335	COG4496	protein, YerC YecD
E3S66_RS00355	COG4851	CamS sex pheromone cAM373 precursor
E3S66_RS00470	COG1295	ribonuclease BN
E3S66_RS00490	COG2309	aminopeptidase activity
E3S66_RS00495	COG1607	acyl-coa hydrolase
E3S66_RS00500	COG0535	radical SAM domain protein
E3S66_RS00530	COG1388	LysM domain
E3S66_RS00530	COG1134	teichoic acid transport
E3S66_RS00540	COG1988	membrane-bound metal-dependent
E3S66_RS00565	COG4129	membrane
E3S66_RS00575	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E3S66_RS00580	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E3S66_RS00755	COG0765	amino acid transport
E3S66_RS00760	COG1126	abc transporter atp-binding protein
E3S66_RS00765	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E3S66_RS00795	COG0564	pseudouridine synthase activity
E3S66_RS00800	COG2203	Gaf domain
E3S66_RS00800	COG4585	Histidine kinase
E3S66_RS00805	COG2197	response regulator
E3S66_RS00830	COG0420	3'-5' exonuclease activity
E3S66_RS00860	COG0537	adenosine 5'-monophosphoramidase activity
E3S66_RS00865	COG1131	(ABC) transporter
E3S66_RS01140	COG2816	NAD+ diphosphatase activity
E3S66_RS01145	COG1506	peptidase
E3S66_RS01165	COG0656	L-ascorbic acid biosynthetic process
E3S66_RS01180	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E3S66_RS01190	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E3S66_RS01220	COG3266	domain, Protein
E3S66_RS01220	COG4193	domain, Protein
E3S66_RS01220	COG5632	N-Acetylmuramoyl-L-alanine amidase
E3S66_RS01240	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E3S66_RS01240	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E3S66_RS01270	COG2267	carboxylic ester hydrolase activity
E3S66_RS01275	COG1846	Transcriptional regulator
E3S66_RS01280	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
E3S66_RS01285	COG1242	4 iron, 4 sulfur cluster binding
E3S66_RS01290	COG2814	Major facilitator Superfamily
E3S66_RS01310	COG2081	HI0933 family
E3S66_RS01315	COG2244	polysaccharide biosynthetic process
E3S66_RS01320	COG1187	pseudouridine synthase activity
E3S66_RS01340	COG0510	thiamine kinase activity
E3S66_RS01350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E3S66_RS01360	COG1363	Peptidase, m42
E3S66_RS01365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E3S66_RS01375	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E3S66_RS01380	COG1674	ftsk spoiiie
E3S66_RS01405	COG1605	Chorismate mutase
E3S66_RS01405	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
E3S66_RS01425	COG0454	-acetyltransferase
E3S66_RS01430	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E3S66_RS01465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E3S66_RS01470	COG0204	Acyl-transferase
E3S66_RS01475	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3S66_RS01475	COG1263	PTS System
E3S66_RS01490	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E3S66_RS01495	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E3S66_RS01500	COG1764	response to oxidative stress
E3S66_RS01505	COG0584	glycerophosphoryl diester phosphodiesterase
E3S66_RS01520	COG1956	GAF domain-containing protein
E3S66_RS01535	COG1104	cysteine desulfurase activity
E3S66_RS01545	COG0730	response to heat
E3S66_RS01555	COG0827	DNA restriction-modification system
E3S66_RS01595	COG4109	DRTGG domain
E3S66_RS01600	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E3S66_RS01610	COG0281	malic enzyme
E3S66_RS01635	COG1113	amino acid transport
E3S66_RS01640	COG0372	Belongs to the citrate synthase family
E3S66_RS01650	COG0745	RESPONSE REGULATOR receiver
E3S66_RS01655	COG5002	protein histidine kinase activity
E3S66_RS01665	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E3S66_RS01665	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E3S66_RS01670	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E3S66_RS01695	COG1484	DNA-dependent DNA replication
E3S66_RS01710	COG0833	amino acid
E3S66_RS01730	COG4112	unkown
E3S66_RS01765	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E3S66_RS01780	COG0113	porphobilinogen synthase activity
E3S66_RS01800	COG2818	Glycosylase
E3S66_RS01810	COG0285	dihydrofolate synthase activity
E3S66_RS01815	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
E3S66_RS01855	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E3S66_RS01900	COG2868	ribosomal protein
E3S66_RS01940	COG1862	Preprotein translocase
E3S66_RS01945	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E3S66_RS01945	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E3S66_RS01950	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E3S66_RS01950	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E3S66_RS01995	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E3S66_RS02000	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E3S66_RS02005	COG1959	2 iron, 2 sulfur cluster binding
E3S66_RS02020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E3S66_RS02025	COG1104	cysteine desulfurase activity
E3S66_RS02040	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E3S66_RS02090	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E3S66_RS02095	COG1984	allophanate hydrolase subunit 2
E3S66_RS02100	COG0511	ligase activity, forming carbon-carbon bonds
E3S66_RS02105	COG0439	Biotin carboxylase
E3S66_RS02115	COG1914	H( )-stimulated, divalent metal cation uptake system
E3S66_RS02140	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
E3S66_RS02145	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
E3S66_RS02155	COG1534	Rna-binding protein
E3S66_RS02165	COG1713	HD superfamily hydrolase involved in NAD metabolism
E3S66_RS02170	COG0799	negative regulation of ribosome biogenesis
E3S66_RS02175	COG2226	methyltransferase
E3S66_RS02180	COG2183	response to ionizing radiation
E3S66_RS02185	COG2131	deaminase
E3S66_RS02190	COG2333	competence protein COMEC
E3S66_RS02190	COG0658	competence protein
E3S66_RS02195	COG1466	dna polymerase III delta subunit
E3S66_RS02210	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E3S66_RS02240	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E3S66_RS02245	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E3S66_RS02255	COG1030	water channel activity
E3S66_RS02270	COG1702	phosphate starvation-inducible protein PhoH
E3S66_RS02285	COG0295	cytidine deaminase activity
E3S66_RS02305	COG0517	IMP dehydrogenase activity
E3S66_RS02320	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E3S66_RS02325	COG2384	SAM-dependent methyltransferase
E3S66_RS02335	COG0513	Belongs to the DEAD box helicase family
E3S66_RS02345	COG1121	(ABC) transporter
E3S66_RS02350	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E3S66_RS02355	COG0735	belongs to the Fur family
E3S66_RS02375	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E3S66_RS02385	COG4483	Protein conserved in bacteria
E3S66_RS02390	COG1940	carbohydrate kinase activity
E3S66_RS02395	COG0011	TIGRFAM Protein of
E3S66_RS02400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E3S66_RS02405	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E3S66_RS02410	COG1459	type II secretion system
E3S66_RS02415	COG4537	Required for transformation and DNA binding
E3S66_RS02460	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E3S66_RS02465	COG0095	Lipoate-protein ligase
E3S66_RS02480	COG0006	proline dipeptidase activity
E3S66_RS02490	COG0511	ligase activity, forming carbon-carbon bonds
E3S66_RS02495	COG0439	Biotin carboxylase
E3S66_RS02500	COG1302	Protein conserved in bacteria
E3S66_RS02530	COG0497	DNA recombination
E3S66_RS02535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3S66_RS02540	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E3S66_RS02545	COG0022	dehydrogenase e1 component
E3S66_RS02550	COG0508	dehydrogenase complex catalyzes the overall conversion of
E3S66_RS02560	COG4129	membrane
E3S66_RS02570	COG2195	Cleaves the N-terminal amino acid of tripeptides
E3S66_RS02595	COG1609	Transcriptional regulator
E3S66_RS02600	COG0366	Alpha amylase catalytic
E3S66_RS02610	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E3S66_RS02625	COG4221	oxidoreductase activity
E3S66_RS02635	COG0667	Aldo Keto reductase
E3S66_RS02640	COG0494	nUDIX hydrolase
E3S66_RS02645	COG0735	belongs to the Fur family
E3S66_RS02670	COG1187	pseudouridine synthase activity
E3S66_RS02675	COG0745	RESPONSE REGULATOR receiver
E3S66_RS02720	COG1141	Ferredoxin
E3S66_RS02730	COG0514	ATP-dependent DNA helicase (RecQ)
E3S66_RS02745	COG0492	ferredoxin-NADP+ reductase activity
E3S66_RS02800	COG0142	geranyltranstransferase activity
E3S66_RS02840	COG4347	Protein of unknown function (DUF1405)
E3S66_RS02845	COG2738	Putative neutral zinc metallopeptidase
E3S66_RS02850	COG1694	Mazg nucleotide pyrophosphohydrolase
E3S66_RS02855	COG0438	transferase activity, transferring glycosyl groups
E3S66_RS02880	COG3935	DnaD domain protein
E3S66_RS02885	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E3S66_RS02895	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E3S66_RS02895	COG4499	WXG100 protein secretion system (Wss), protein YukC
E3S66_RS02930	COG0116	Belongs to the methyltransferase superfamily
E3S66_RS02945	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
E3S66_RS02950	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E3S66_RS02965	COG0531	amino acid
E3S66_RS02985	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E3S66_RS03060	COG0671	phosphoesterase, PA-phosphatase related
E3S66_RS03110	COG4548	von Willebrand factor, type A
E3S66_RS03180	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E3S66_RS03185	COG0527	aspartate kinase activity
E3S66_RS03190	COG0488	(ABC) transporter
E3S66_RS03210	COG0573	inorganic phosphate transmembrane transporter activity
E3S66_RS03215	COG0581	inorganic phosphate transmembrane transporter activity
E3S66_RS03225	COG0704	Plays a role in the regulation of phosphate uptake
E3S66_RS03280	COG2348	transferase activity, transferring amino-acyl groups
E3S66_RS03315	COG0512	Glutamine amidotransferase of anthranilate synthase
E3S66_RS03320	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E3S66_RS03325	COG1363	Peptidase, m42
E3S66_RS03335	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E3S66_RS03345	COG1316	TRANSCRIPTIONal
E3S66_RS03350	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E3S66_RS03360	COG0628	permease
E3S66_RS03375	COG1115	amino acid carrier protein
E3S66_RS03400	COG0824	Thioesterase
E3S66_RS03410	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E3S66_RS03430	COG4846	Membrane protein involved in cytochrome C biogenesis
E3S66_RS03465	COG2340	Cysteine-rich secretory protein family
E3S66_RS03495	COG0833	amino acid
E3S66_RS03520	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E3S66_RS03525	COG0460	homoserine dehydrogenase
E3S66_RS03530	COG0527	aspartate kinase activity
E3S66_RS03545	COG1525	nuclease
E3S66_RS03555	COG2197	response regulator
E3S66_RS03570	COG1131	(ABC) transporter
E3S66_RS03650	COG0789	Transcriptional regulator
E3S66_RS03655	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
E3S66_RS03660	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E3S66_RS03670	COG1923	regulation of RNA biosynthetic process
E3S66_RS03695	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E3S66_RS03700	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
E3S66_RS03735	COG1013	pyruvate-flavodoxin oxidoreductase activity
E3S66_RS03740	COG0674	pyruvate-flavodoxin oxidoreductase activity
E3S66_RS03740	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E3S66_RS03745	COG1692	metallophosphoesterase
E3S66_RS03765	COG1546	Belongs to the CinA family
E3S66_RS03765	COG1058	Belongs to the CinA family
E3S66_RS03785	COG0300	oxidoreductase activity
E3S66_RS03790	COG0612	Peptidase, M16
E3S66_RS03795	COG0612	Peptidase, M16
E3S66_RS03800	COG2188	Transcriptional regulator
E3S66_RS03825	COG0196	riboflavin kinase activity
E3S66_RS03850	COG2740	Nucleic-acid-binding protein implicated in transcription termination
E3S66_RS03855	COG0195	Participates in both transcription termination and antitermination
E3S66_RS03955	COG2348	transferase activity, transferring amino-acyl groups
E3S66_RS04010	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E3S66_RS04020	COG0552	protein localization to endoplasmic reticulum
E3S66_RS04025	COG1196	nuclear chromosome segregation
E3S66_RS04070	COG1302	Protein conserved in bacteria
E3S66_RS04085	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E3S66_RS04100	COG0631	protein serine/threonine phosphatase activity
E3S66_RS04110	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E3S66_RS04110	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E3S66_RS04125	COG2314	TM2 domain
E3S66_RS04135	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E3S66_RS04140	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E3S66_RS04200	COG2233	PERMEase
E3S66_RS04210	COG0564	pseudouridine synthase activity
E3S66_RS04225	COG2514	catechol 2,3-dioxygenase activity
E3S66_RS04235	COG3599	regulation of cell shape
E3S66_RS04240	COG2302	S4 RNA-binding domain
E3S66_RS04245	COG0762	integral membrane protein
E3S66_RS04255	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E3S66_RS04265	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E3S66_RS04270	COG0849	cell division
E3S66_RS04275	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E3S66_RS04295	COG4839	cell division protein FtsL
E3S66_RS04320	COG1011	Hydrolase
E3S66_RS04355	COG1288	antiporter activity
E3S66_RS04465	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E3S66_RS04470	COG1053	succinate dehydrogenase
E3S66_RS04475	COG2009	succinate dehydrogenase
E3S66_RS04500	COG1796	DNA polymerase
E3S66_RS04500	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E3S66_RS04530	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E3S66_RS04545	COG4509	Sortase family
E3S66_RS04600	COG0742	ribosomal rna small subunit methyltransferase
E3S66_RS04620	COG3679	Belongs to the UPF0342 family
E3S66_RS04645	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
E3S66_RS04650	COG0772	Belongs to the SEDS family
E3S66_RS04660	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E3S66_RS04680	COG0483	inositol monophosphate 1-phosphatase activity
E3S66_RS04705	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E3S66_RS04710	COG1177	transmembrane transport
E3S66_RS04715	COG1176	ABC-type spermidine putrescine transport system, permease component I
E3S66_RS04780	COG0569	domain protein
E3S66_RS04785	COG1294	oxidase, subunit
E3S66_RS04790	COG1271	oxidase subunit
E3S66_RS04795	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E3S66_RS04815	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E3S66_RS04835	COG4721	ABC-type cobalt transport system, permease component
E3S66_RS04840	COG4172	Belongs to the ABC transporter superfamily
E3S66_RS04845	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
E3S66_RS04885	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E3S66_RS04900	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E3S66_RS04945	COG1316	TRANSCRIPTIONal
E3S66_RS04955	COG2153	protein acetylation
E3S66_RS04975	COG3594	Acyltransferase
E3S66_RS04980	COG0436	Aminotransferase
E3S66_RS05005	COG2267	carboxylic ester hydrolase activity
E3S66_RS05015	COG1169	isochorismate synthase
E3S66_RS05025	COG1575	Belongs to the MenA family. Type 1 subfamily
E3S66_RS05030	COG0456	acetyltransferase
E3S66_RS05035	COG2314	TM2 domain
E3S66_RS05045	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
E3S66_RS05100	COG4873	Protein conserved in bacteria
E3S66_RS05115	COG4903	ComK protein
E3S66_RS05130	COG0737	Belongs to the 5'-nucleotidase family
E3S66_RS05135	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E3S66_RS05145	COG0861	Integral membrane protein TerC family
E3S66_RS05185	COG1115	amino acid carrier protein
E3S66_RS05190	COG0628	permease
E3S66_RS05200	COG0569	domain protein
E3S66_RS05200	COG0475	glutathione-regulated potassium exporter activity
E3S66_RS05205	COG2239	Acts as a magnesium transporter
E3S66_RS05210	COG0564	pseudouridine synthase activity
E3S66_RS05220	COG2357	RelA SpoT domain protein
E3S66_RS05235	COG2346	COG2346, Truncated hemoglobins
E3S66_RS05245	COG1164	Oligoendopeptidase f
E3S66_RS05270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3S66_RS05275	COG0601	transmembrane transport
E3S66_RS05280	COG4608	Belongs to the ABC transporter superfamily
E3S66_RS05285	COG0444	Belongs to the ABC transporter superfamily
E3S66_RS05290	COG0747	negative chemotaxis
E3S66_RS05295	COG4166	transmembrane transport
E3S66_RS05300	COG4608	Belongs to the ABC transporter superfamily
E3S66_RS05305	COG0444	Belongs to the ABC transporter superfamily
E3S66_RS05310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3S66_RS05315	COG0601	transmembrane transport
E3S66_RS05345	COG1881	PFAM PEBP family protein
E3S66_RS05385	COG0561	phosphatase activity
E3S66_RS05425	COG0398	Pfam SNARE associated Golgi protein
E3S66_RS05445	COG0584	glycerophosphoryl diester phosphodiesterase
E3S66_RS05460	COG1902	pentaerythritol trinitrate reductase activity
E3S66_RS05465	COG1098	S1 RNA binding domain
E3S66_RS05520	COG2050	protein possibly involved in aromatic compounds catabolism
E3S66_RS05525	COG2056	Na+-H+ antiporter family
E3S66_RS05530	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E3S66_RS05540	COG0316	Belongs to the HesB IscA family
E3S66_RS05550	COG1252	NADH dehydrogenase
E3S66_RS05555	COG4837	Protein of unknown function (DUF1462)
E3S66_RS05560	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E3S66_RS05565	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
E3S66_RS05575	COG1696	Membrane protein involved in D-alanine export
E3S66_RS05605	COG2445	Protein of unknown function DUF86
E3S66_RS05620	COG4470	Protein conserved in bacteria
E3S66_RS05635	COG0730	response to heat
E3S66_RS05640	COG1801	Protein of unknown function DUF72
E3S66_RS05655	COG1253	flavin adenine dinucleotide binding
E3S66_RS05690	COG1388	LysM domain
E3S66_RS05690	COG0860	N-Acetylmuramoyl-L-alanine amidase
E3S66_RS05920	COG1484	DNA-dependent DNA replication
E3S66_RS05995	COG1396	sequence-specific DNA binding
E3S66_RS06030	COG0822	iron-sulfur transferase activity
E3S66_RS06040	COG0719	Fe-S assembly protein
E3S66_RS06045	COG0396	ATPase activity
E3S66_RS06060	COG1464	Belongs to the NlpA lipoprotein family
E3S66_RS06065	COG2011	ABC-type metal ion transport system permease component
E3S66_RS06080	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
E3S66_RS06085	COG3878	Protein conserved in bacteria
E3S66_RS06100	COG1393	Belongs to the ArsC family
E3S66_RS06105	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E3S66_RS06130	COG1279	arginine transmembrane transporter activity
E3S66_RS06135	COG0406	alpha-ribazole phosphatase activity
E3S66_RS06175	COG1278	Cold shock
E3S66_RS06245	COG0557	exoribonuclease II activity
E3S66_RS06250	COG1647	Serine aminopeptidase, S33
E3S66_RS06255	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E3S66_RS06315	COG0391	Required for morphogenesis under gluconeogenic growth conditions
E3S66_RS06370	COG3942	CHAP domain
E3S66_RS06370	COG1388	LysM domain
E3S66_RS06400	COG1040	competence protein
E3S66_RS06405	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
E3S66_RS06415	COG1739	Uncharacterized protein family UPF0029
E3S66_RS06420	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E3S66_RS06480	COG4607	ABC-type enterochelin transport system periplasmic component
E3S66_RS06485	COG4604	ABC transporter, ATP-binding protein
E3S66_RS06490	COG4605	iron ion homeostasis
E3S66_RS06495	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3S66_RS06505	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E3S66_RS06510	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E3S66_RS06530	COG3104	oligopeptide transport
E3S66_RS06555	COG1174	glycine betaine transport
E3S66_RS06560	COG1125	glycine betaine transport
E3S66_RS06560	COG0517	IMP dehydrogenase activity
E3S66_RS06565	COG0514	ATP-dependent DNA helicase (RecQ)
E3S66_RS06570	COG0488	(ABC) transporter
E3S66_RS06600	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E3S66_RS06605	COG0512	Glutamine amidotransferase of anthranilate synthase
E3S66_RS06605	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E3S66_RS06615	COG0720	synthase
E3S66_RS06650	COG0463	Glycosyl transferase, family 2
E3S66_RS06655	COG0656	L-ascorbic acid biosynthetic process
E3S66_RS06660	COG1253	flavin adenine dinucleotide binding
E3S66_RS06665	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E3S66_RS06670	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3S66_RS06670	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3S66_RS06670	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3S66_RS06675	COG1105	Belongs to the carbohydrate kinase PfkB family
E3S66_RS06680	COG1349	DNA-binding transcription factor activity
E3S66_RS06685	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E3S66_RS06720	COG0471	metal ion transport
E3S66_RS06730	COG4989	oxidoreductase activity
E3S66_RS06735	COG0523	cobalamin synthesis protein
E3S66_RS06740	COG1846	Transcriptional regulator
E3S66_RS06745	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E3S66_RS06750	COG4988	ABC transporter
E3S66_RS06770	COG1611	Belongs to the LOG family
E3S66_RS06800	COG2839	Protein conserved in bacteria
E3S66_RS06805	COG2814	Major facilitator Superfamily
E3S66_RS06810	COG0583	DNA-binding transcription factor activity
E3S66_RS06850	COG1388	LysM domain
E3S66_RS06850	COG3942	CHAP domain
E3S66_RS06855	COG0306	phosphate transporter
E3S66_RS06860	COG1392	Phosphate transport regulator
E3S66_RS06865	COG0577	efflux transmembrane transporter activity
E3S66_RS06870	COG1136	(ABC) transporter
E3S66_RS06905	COG3949	Membrane
E3S66_RS06915	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
E3S66_RS06925	COG2376	Dihydroxyacetone kinase
E3S66_RS06930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3S66_RS06935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3S66_RS06940	COG1120	ATPase activity
E3S66_RS06945	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E3S66_RS06955	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E3S66_RS06960	COG1132	(ABC) transporter
E3S66_RS06965	COG1686	Belongs to the peptidase S11 family
E3S66_RS06970	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E3S66_RS06980	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E3S66_RS06985	COG1682	transport, permease protein
E3S66_RS06995	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
E3S66_RS07005	COG1321	iron dependent repressor
E3S66_RS07010	COG1121	(ABC) transporter
E3S66_RS07015	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E3S66_RS07020	COG0803	Belongs to the bacterial solute-binding protein 9 family
E3S66_RS07070	COG4974	Belongs to the 'phage' integrase family
E3S66_RS07125	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E3S66_RS07160	COG1078	dGTPase activity
E3S66_RS07170	COG0655	NAD(P)H dehydrogenase (quinone) activity
E3S66_RS07175	COG0667	Aldo Keto reductase
E3S66_RS07210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3S66_RS07230	COG0083	homoserine kinase activity
E3S66_RS07235	COG0095	Lipoate-protein ligase
E3S66_RS07325	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
E3S66_RS07340	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E3S66_RS07380	COG0561	phosphatase activity
E3S66_RS07390	COG1428	Deoxynucleoside kinase
E3S66_RS07395	COG1428	Deoxynucleoside kinase
E3S66_RS07400	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E3S66_RS07430	COG1473	amidohydrolase
E3S66_RS07460	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E3S66_RS07470	COG2813	Specifically methylates the guanine in position
E3S66_RS07500	COG0250	Participates in transcription elongation, termination and antitermination
E3S66_RS07505	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E3S66_RS07530	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
E3S66_RS07550	COG4956	integral membrane protein (PIN domain superfamily)
E3S66_RS07555	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E3S66_RS07570	COG3880	PFAM UvrB UvrC protein
E3S66_RS07580	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E3S66_RS07595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E3S66_RS07690	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E3S66_RS07715	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E3S66_RS07730	COG1098	S1 RNA binding domain
E3S66_RS07740	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E3S66_RS07745	COG3956	TIGRFAM MazG family protein
E3S66_RS07750	COG2244	polysaccharide biosynthetic process
E3S66_RS07790	COG0251	oxidation-reduction process
E3S66_RS07795	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E3S66_RS07805	COG4466	Protein conserved in bacteria
E3S66_RS07815	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
E3S66_RS07820	COG0084	hydrolase, TatD family'
E3S66_RS07830	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E3S66_RS07840	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E3S66_RS07850	COG1774	PSP1 C-terminal conserved region
E3S66_RS07855	COG0470	DNA polymerase III
E3S66_RS07860	COG3870	Protein conserved in bacteria
E3S66_RS07870	COG1982	Orn Lys Arg decarboxylase major
E3S66_RS07900	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E3S66_RS07905	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E3S66_RS07925	COG2188	Transcriptional regulator
E3S66_RS07930	COG0366	Alpha amylase catalytic
E3S66_RS07935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3S66_RS07935	COG1263	PTS System
E3S66_RS07945	COG0493	'glutamate synthase
E3S66_RS07950	COG0067	glutamate synthase
E3S66_RS07950	COG0070	glutamate synthase
E3S66_RS07950	COG0069	glutamate synthase activity
E3S66_RS07955	COG0583	DNA-binding transcription factor activity
E3S66_RS07990	COG1464	Belongs to the NlpA lipoprotein family
E3S66_RS07995	COG2011	ABC-type metal ion transport system permease component
E3S66_RS08005	COG0626	cystathionine gamma-synthase activity
E3S66_RS08010	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E3S66_RS08015	COG0733	neurotransmitter:sodium symporter activity
E3S66_RS08020	COG1647	Serine aminopeptidase, S33
E3S66_RS08035	COG5609	conserved protein (DUF2294)
E3S66_RS08045	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E3S66_RS08070	COG0523	cobalamin synthesis protein
E3S66_RS08230	COG3759	membrane
E3S66_RS08265	COG2233	PERMEase
E3S66_RS08295	COG1823	symporter activity
E3S66_RS08395	COG0012	GTP binding
E3S66_RS08400	COG4481	Protein conserved in bacteria
E3S66_RS08405	COG0668	transmembrane transport
E3S66_RS08410	COG1475	DNA binding
E3S66_RS08415	COG0626	cystathionine gamma-synthase activity
E3S66_RS08420	COG0626	cystathionine gamma-synthase activity
E3S66_RS08425	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E3S66_RS08425	COG0646	methionine synthase
E3S66_RS08455	COG1131	(ABC) transporter
E3S66_RS08465	COG1476	TRANSCRIPTIONal
E3S66_RS08475	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E3S66_RS08480	COG0805	protein transport
E3S66_RS08485	COG0672	)-iron permease
E3S66_RS08490	COG2837	iron assimilation
E3S66_RS08495	COG2822	iron ion transport
E3S66_RS08500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E3S66_RS08510	COG0431	NADPH-dependent FMN reductase
E3S66_RS08515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E3S66_RS08520	COG0346	lactoylglutathione lyase activity
E3S66_RS08525	COG2271	Major facilitator Superfamily
E3S66_RS08550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3S66_RS08560	COG3037	sugar-specific permease SgaT UlaA
E3S66_RS08590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E3S66_RS08610	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E3S66_RS08610	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
E3S66_RS08615	COG1388	LysM domain
E3S66_RS08615	COG0860	N-Acetylmuramoyl-L-alanine amidase
E3S66_RS08665	COG5412	phage tail tape measure protein
E3S66_RS08665	COG3953	SLT domain
E3S66_RS08890	COG3646	Phage regulatory protein
E3S66_RS08890	COG3645	SOS response
E3S66_RS08925	COG0582	viral genome integration into host DNA
E3S66_RS08960	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E3S66_RS08965	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E3S66_RS08995	COG0577	efflux transmembrane transporter activity
E3S66_RS09000	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
E3S66_RS09005	COG1114	Component of the transport system for branched-chain amino acids
E3S66_RS09125	COG3942	CHAP domain
E3S66_RS09125	COG1388	LysM domain
E3S66_RS09200	COG2226	methyltransferase
E3S66_RS09205	COG2723	6-phospho-beta-galactosidase activity
E3S66_RS09210	COG1263	PTS System
E3S66_RS09210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3S66_RS09210	COG2190	(PTS) system
E3S66_RS09215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E3S66_RS09250	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E3S66_RS09255	COG1063	alcohol dehydrogenase
E3S66_RS09265	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E3S66_RS09270	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E3S66_RS09275	COG1063	alcohol dehydrogenase
E3S66_RS09280	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E3S66_RS09285	COG1063	alcohol dehydrogenase
E3S66_RS09295	COG1063	alcohol dehydrogenase
E3S66_RS09300	COG3775	system Galactitol-specific IIC component
E3S66_RS09305	COG3414	Phosphotransferase system galactitol-specific IIB component
E3S66_RS09325	COG1957	nucleoside hydrolase
E3S66_RS09330	COG1263	PTS System
E3S66_RS09330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3S66_RS09330	COG2190	(PTS) system
E3S66_RS09355	COG3189	MarR family transcriptional regulator
E3S66_RS09360	COG0747	negative chemotaxis
E3S66_RS09375	COG0318	PFAM AMP-dependent synthetase and ligase
E3S66_RS09380	COG1960	acyl-CoA dehydrogenase activity
E3S66_RS09390	COG0183	Belongs to the thiolase family
E3S66_RS09445	COG1755	Isoprenylcysteine carboxyl methyltransferase
E3S66_RS09455	COG0673	inositol 2-dehydrogenase activity
E3S66_RS09460	COG0673	inositol 2-dehydrogenase activity
E3S66_RS09465	COG3833	ABC-type maltose transport systems, permease component
E3S66_RS09470	COG1175	transmembrane transport
E3S66_RS09480	COG3842	ATPase activity
E3S66_RS09500	COG0405	Gamma-glutamyltransferase
E3S66_RS09510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3S66_RS09555	COG1136	(ABC) transporter
E3S66_RS09580	COG1737	Transcriptional regulator
E3S66_RS09610	COG3961	Belongs to the TPP enzyme family
E3S66_RS09615	COG1335	isochorismatase
E3S66_RS09620	COG1114	Component of the transport system for branched-chain amino acids
E3S66_RS09670	COG5609	conserved protein (DUF2294)
E3S66_RS09675	COG1960	acyl-CoA dehydrogenase activity
E3S66_RS09680	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E3S66_RS09715	COG2832	Protein of unknown function (DUF454)
E3S66_RS09725	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E3S66_RS09730	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E3S66_RS09740	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E3S66_RS09770	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E3S66_RS09780	COG1086	Polysaccharide biosynthesis protein
E3S66_RS09805	COG1012	belongs to the aldehyde dehydrogenase family
E3S66_RS09805	COG1454	alcohol dehydrogenase
E3S66_RS09820	COG0737	Belongs to the 5'-nucleotidase family
E3S66_RS09840	COG3639	organic phosphonate transmembrane transporter activity
E3S66_RS09860	COG2814	Major facilitator Superfamily
E3S66_RS09865	COG0813	purine-nucleoside phosphorylase activity
E3S66_RS09895	COG0438	transferase activity, transferring glycosyl groups
E3S66_RS09900	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E3S66_RS09905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3S66_RS09925	COG1475	DNA binding
E3S66_RS09930	COG0019	diaminopimelate decarboxylase activity
E3S66_RS09940	COG4264	IucA IucC family
E3S66_RS09945	COG4264	IucA IucC family
E3S66_RS09950	COG2814	Major facilitator Superfamily
E3S66_RS09955	COG4264	IucA IucC family
E3S66_RS09960	COG2423	ornithine cyclodeaminase activity
E3S66_RS09970	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E3S66_RS09975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3S66_RS09980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3S66_RS09995	COG1620	l-lactate permease
E3S66_RS10010	COG0697	spore germination
E3S66_RS10015	COG4716	Myosin-crossreactive antigen
E3S66_RS10020	COG1283	sodium-dependent phosphate transmembrane transporter activity
E3S66_RS10030	COG1473	amidohydrolase
E3S66_RS10065	COG0823	Involved in the tonB-independent uptake of proteins
E3S66_RS10110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E3S66_RS10115	COG2210	Belongs to the sulfur carrier protein TusA family
E3S66_RS10120	COG1937	Protein conserved in bacteria
E3S66_RS10125	COG0730	response to heat
E3S66_RS10195	COG2205	protein histidine kinase activity
E3S66_RS10200	COG0745	RESPONSE REGULATOR receiver
E3S66_RS10255	COG2003	Belongs to the UPF0758 family
E3S66_RS10290	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E3S66_RS10300	COG0730	response to heat
E3S66_RS10305	COG1937	Protein conserved in bacteria
E3S66_RS10310	COG2210	Belongs to the sulfur carrier protein TusA family
E3S66_RS10315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E3S66_RS10325	COG1846	Transcriptional regulator
E3S66_RS10325	COG1940	carbohydrate kinase activity
E3S66_RS10340	COG4219	Peptidase M56
E3S66_RS10340	COG2602	Beta-lactamase
E3S66_RS10350	COG2030	dehydratase
E3S66_RS10355	COG0584	glycerophosphoryl diester phosphodiesterase
E3S66_RS10360	COG3316	Transposase and inactivated derivatives
E3S66_RS10375	COG3316	Transposase and inactivated derivatives
E3S66_RS10395	COG3316	Transposase and inactivated derivatives
E3S66_RS10415	COG0737	Belongs to the 5'-nucleotidase family
E3S66_RS10420	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E3S66_RS10430	COG4863	YycH protein
E3S66_RS10460	COG0305	Participates in initiation and elongation during chromosome replication
E3S66_RS10470	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
E3S66_RS10480	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E3S66_RS10505	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E3S66_RS10525	COG2501	S4 domain
E3S66_RS10565	COG1475	DNA binding
E3S66_RS10585	COG1278	Cold shock
E3S66_RS10595	COG0577	efflux transmembrane transporter activity
E3S66_RS10600	COG1136	(ABC) transporter
E3S66_RS10615	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
E3S66_RS10625	COG2962	Rard protein
E3S66_RS10630	COG0471	metal ion transport
E3S66_RS10715	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E3S66_RS10755	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
E3S66_RS10770	COG1215	transferase activity, transferring glycosyl groups
E3S66_RS10775	COG1309	transcriptional regulator
E3S66_RS10805	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E3S66_RS10825	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E3S66_RS10845	COG1073	alpha beta
E3S66_RS10860	COG0438	transferase activity, transferring glycosyl groups
E3S66_RS10875	COG1535	isochorismatase
E3S66_RS10875	COG3433	isochorismatase activity
E3S66_RS10880	COG3942	CHAP domain
E3S66_RS10880	COG1705	Flagellar rod assembly protein muramidase FlgJ
E3S66_RS10890	COG1482	cell wall glycoprotein biosynthetic process
E3S66_RS10895	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3S66_RS10895	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3S66_RS10895	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3S66_RS10900	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3S66_RS10900	COG3711	transcriptional antiterminator
E3S66_RS10955	COG4932	domain protein
E3S66_RS10955	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
E3S66_RS10965	COG1846	Transcriptional regulator
E3S66_RS10975	COG1785	Belongs to the alkaline phosphatase family
E3S66_RS10985	COG0745	RESPONSE REGULATOR receiver
E3S66_RS10990	COG2205	protein histidine kinase activity
E3S66_RS10995	COG1136	(ABC) transporter
E3S66_RS11015	COG0386	Belongs to the glutathione peroxidase family
E3S66_RS11025	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E3S66_RS11040	COG2851	Citrate transporter
E3S66_RS11065	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E3S66_RS11070	COG1510	regulation of RNA biosynthetic process
E3S66_RS11100	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E3S66_RS11130	COG0531	amino acid
E3S66_RS11140	COG3527	Alpha-acetolactate decarboxylase
E3S66_RS11145	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E3S66_RS11205	COG0167	dihydroorotate dehydrogenase activity
E3S66_RS11315	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E3S66_RS11315	COG2755	lipolytic protein G-D-S-L family
E3S66_RS11350	COG0436	Aminotransferase
E3S66_RS11395	COG2409	Drug exporters of the RND superfamily
E3S66_RS11420	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E3S66_RS11425	COG3425	synthase
E3S66_RS11435	COG3942	CHAP domain
E3S66_RS11445	COG0583	DNA-binding transcription factor activity
E3S66_RS11455	COG1346	cytolysis
E3S66_RS11460	COG0028	Belongs to the TPP enzyme family
E3S66_RS11480	COG0657	acetylesterase activity
E3S66_RS11485	COG0697	spore germination
E3S66_RS11500	COG1760	l-serine dehydratase
E3S66_RS11505	COG1760	l-serine dehydratase
E3S66_RS11525	COG3764	Sortase (surface protein transpeptidase)
E3S66_RS11535	COG1131	(ABC) transporter
E3S66_RS11540	COG0561	phosphatase activity
E3S66_RS11555	COG2514	catechol 2,3-dioxygenase activity
E3S66_RS11565	COG1846	Transcriptional regulator
E3S66_RS11570	COG0346	lactoylglutathione lyase activity
E3S66_RS11575	COG0400	carboxylic ester hydrolase activity
E3S66_RS11595	COG1131	(ABC) transporter
E3S66_RS11605	COG0586	Pfam SNARE associated Golgi protein
E3S66_RS11610	COG2271	Major facilitator Superfamily
E3S66_RS11620	COG4876	unkown
E3S66_RS11625	COG2357	RelA SpoT domain protein
E3S66_RS11630	COG0789	Transcriptional regulator
E3S66_RS11635	COG1802	Transcriptional regulator
E3S66_RS11640	COG1070	Carbohydrate kinase
E3S66_RS11675	COG1846	Transcriptional regulator
E3S66_RS11715	COG0494	nUDIX hydrolase
E3S66_RS11805	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E3S66_RS11810	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
E3S66_RS11815	COG1028	Short-chain dehydrogenase reductase Sdr
E3S66_RS11820	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E3S66_RS11875	COG0069	glutamate synthase activity
E3S66_RS11880	COG4808	Protein conserved in bacteria
E3S66_RS11895	COG1363	Peptidase, m42
E3S66_RS11900	COG4619	ABC transporter
E3S66_RS11905	COG0390	transport system, permease component
E3S66_RS11910	COG2814	Major facilitator Superfamily
E3S66_RS11915	COG2272	Belongs to the type-B carboxylesterase lipase family
E3S66_RS11920	COG0531	amino acid
E3S66_RS11925	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
E3S66_RS11945	COG1174	glycine betaine transport
E3S66_RS11955	COG1174	glycine betaine transport
E3S66_RS11965	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E3S66_RS11980	COG0531	amino acid
E3S66_RS11990	COG1113	amino acid transport
E3S66_RS12010	COG2814	Major facilitator Superfamily
E3S66_RS12020	COG1929	Belongs to the glycerate kinase type-1 family
E3S66_RS12040	COG1132	(ABC) transporter
E3S66_RS12050	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E3S66_RS12055	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E3S66_RS12065	COG0156	8-amino-7-oxononanoate synthase activity
E3S66_RS12105	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E3S66_RS12120	COG2814	Major facilitator Superfamily
E3S66_RS12125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3S66_RS12130	COG0765	amino acid transport
E3S66_RS12135	COG1126	abc transporter atp-binding protein
E3S66_RS12175	COG3443	Belongs to the bacterial solute-binding protein 9 family
E3S66_RS12175	COG0803	Belongs to the bacterial solute-binding protein 9 family
E3S66_RS12190	COG2116	formate transmembrane transporter activity
E3S66_RS12195	COG0454	-acetyltransferase
E3S66_RS12205	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E3S66_RS12210	COG2146	nitrite reductase [NAD(P)H] activity
E3S66_RS12220	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
E3S66_RS12225	COG1140	nitrate reductase beta subunit
E3S66_RS12235	COG2181	nitrate reductase activity
E3S66_RS12255	COG0789	Transcriptional regulator
E3S66_RS12295	COG3871	stress protein (general stress protein 26)
E3S66_RS12310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3S66_RS12310	COG1263	PTS System
E3S66_RS12325	COG1511	domain protein
E3S66_RS12350	COG0604	alcohol dehydrogenase
E3S66_RS12370	COG1620	l-lactate permease
E3S66_RS12430	COG2814	Major facilitator Superfamily
E3S66_RS12440	COG1566	PFAM secretion protein HlyD family protein
E3S66_RS12445	COG2814	Major facilitator Superfamily
E3S66_RS12455	COG0657	acetylesterase activity
E3S66_RS12470	COG0598	Magnesium transport protein CorA
E3S66_RS12480	COG0786	glutamate:sodium symporter activity
E3S66_RS12490	COG3152	Membrane
E3S66_RS12495	COG4152	abc transporter atp-binding protein
E3S66_RS12500	COG1668	transmembrane transport
E3S66_RS12520	COG2258	MOSC domain
E3S66_RS12545	COG0583	DNA-binding transcription factor activity
E3S66_RS12560	COG1473	amidohydrolase
E3S66_RS12565	COG1028	Short-chain dehydrogenase reductase Sdr
E3S66_RS12585	COG1737	Transcriptional regulator
E3S66_RS12590	COG1263	PTS System
E3S66_RS12590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3S66_RS12600	COG0385	Bile acid
E3S66_RS12605	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E3S66_RS12625	COG1113	amino acid transport
E3S66_RS12705	COG1757	Na H antiporter
E3S66_RS12715	COG3942	CHAP domain
E3S66_RS12775	COG4413	Urea transporter
E3S66_RS12780	COG1960	acyl-CoA dehydrogenase activity
E3S66_RS12795	COG1268	BioY protein
E3S66_RS12810	COG0725	ABC transporter, periplasmic molybdate-binding protein
E3S66_RS12815	COG4149	molybdate abc transporter
E3S66_RS12820	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
E3S66_RS12825	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E3S66_RS12845	COG1763	Mo-molybdopterin cofactor biosynthetic process
E3S66_RS12905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E3S66_RS12950	COG2252	PERMEase
E3S66_RS13065	COG0201	protein transport
E3S66_RS13175	COG0028	Belongs to the TPP enzyme family
E3S66_RS13180	COG3527	Alpha-acetolactate decarboxylase
E3S66_RS13200	COG5492	domain, Protein
E3S66_RS13210	COG0789	Transcriptional regulator
E3S66_RS13215	COG0656	L-ascorbic acid biosynthetic process
E3S66_RS13280	COG2130	NADP-dependent
E3S66_RS13290	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E3S66_RS13315	COG2814	Major facilitator Superfamily
E3S66_RS13320	COG4264	IucA IucC family
E3S66_RS13325	COG3457	Alanine racemase
E3S66_RS13335	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
E3S66_RS13340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3S66_RS13345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3S66_RS13360	COG1988	membrane-bound metal-dependent
E3S66_RS13370	COG1272	protein, Hemolysin III
E3S66_RS13385	COG2814	Major facilitator Superfamily
E3S66_RS13390	COG0489	protein tyrosine kinase activity
E3S66_RS13455	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
E3S66_RS13485	COG3711	transcriptional antiterminator
E3S66_RS13500	COG1119	ATPase activity
E3S66_RS13505	COG0561	phosphatase activity
E3S66_RS13530	COG0640	Transcriptional regulator
E3S66_RS13535	COG0702	epimerase
E3S66_RS13540	COG1482	cell wall glycoprotein biosynthetic process
E3S66_RS13560	COG0783	Belongs to the Dps family
E3S66_RS13565	COG0813	purine-nucleoside phosphorylase activity
E3S66_RS13610	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E3S66_RS13650	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E3S66_RS13670	COG2890	protein-(glutamine-N5) methyltransferase activity
E3S66_RS13675	COG0009	L-threonylcarbamoyladenylate synthase
E3S66_RS13700	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E3S66_RS13775	COG0629	single-stranded DNA binding
E3S66_RS13825	COG1418	mRNA catabolic process
E3S66_RS13835	COG1937	Protein conserved in bacteria
E3S66_RS13850	COG0772	Belongs to the SEDS family
E3S66_RS13860	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E3S66_RS13875	COG0745	RESPONSE REGULATOR receiver
E3S66_RS13880	COG2205	protein histidine kinase activity
E3S66_RS13910	COG3428	Bacterial PH domain
E3S66_RS13940	COG2208	phosphoserine phosphatase activity
E3S66_RS13945	COG1366	Belongs to the anti-sigma-factor antagonist family
E3S66_RS13955	COG1191	sigma factor activity
E3S66_RS13960	COG2183	response to ionizing radiation
E3S66_RS14030	COG0028	Belongs to the TPP enzyme family
E3S66_RS14045	COG0802	atpase or kinase
E3S66_RS14050	COG1214	PFAM Peptidase M22, glycoprotease
E3S66_RS14055	COG0456	acetyltransferase
E3S66_RS14065	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E3S66_RS14075	COG0488	(ABC) transporter
E3S66_RS14085	COG2391	methyltransferase activity
E3S66_RS14090	COG0425	Belongs to the sulfur carrier protein TusA family
E3S66_RS14095	COG0004	ammonium transporteR
E3S66_RS14100	COG1609	Transcriptional regulator
E3S66_RS14105	COG1621	beta-fructofuranosidase activity
E3S66_RS14110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3S66_RS14175	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E3S66_RS14230	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E3S66_RS14440	COG1192	Involved in chromosome partitioning
E3S66_RS14480	COG0629	single-stranded DNA binding
E3S66_RS14515	COG3942	CHAP domain
E3S66_RS14560	COG0551	DNA topoisomerase type I activity
E3S66_RS14560	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E3S66_RS14575	COG0551	DNA topoisomerase type I activity
E3S66_RS14660	COG0604	alcohol dehydrogenase