locus-tag	class	description
E3T12_RS00020	COG4695	Portal protein
E3T12_RS00075	COG0739	heme binding
E3T12_RS00120	COG1388	LysM domain
E3T12_RS00120	COG5632	N-Acetylmuramoyl-L-alanine amidase
E3T12_RS00140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E3T12_RS00170	COG3037	sugar-specific permease SgaT UlaA
E3T12_RS00180	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3T12_RS00205	COG2271	Major facilitator Superfamily
E3T12_RS00210	COG0346	lactoylglutathione lyase activity
E3T12_RS00215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E3T12_RS00230	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E3T12_RS00235	COG2822	iron ion transport
E3T12_RS00240	COG2837	iron assimilation
E3T12_RS00245	COG0672	)-iron permease
E3T12_RS00250	COG0805	protein transport
E3T12_RS00255	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E3T12_RS00265	COG1476	TRANSCRIPTIONal
E3T12_RS00275	COG1131	(ABC) transporter
E3T12_RS00305	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E3T12_RS00305	COG0646	methionine synthase
E3T12_RS00310	COG0626	cystathionine gamma-synthase activity
E3T12_RS00315	COG0626	cystathionine gamma-synthase activity
E3T12_RS00320	COG1475	DNA binding
E3T12_RS00325	COG0668	transmembrane transport
E3T12_RS00330	COG4481	Protein conserved in bacteria
E3T12_RS00335	COG0012	GTP binding
E3T12_RS00445	COG5484	DNA packaging
E3T12_RS00445	COG3728	DNA packaging
E3T12_RS00535	COG1823	symporter activity
E3T12_RS00565	COG2233	PERMEase
E3T12_RS00600	COG3759	membrane
E3T12_RS00735	COG0523	cobalamin synthesis protein
E3T12_RS00760	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E3T12_RS00770	COG5609	conserved protein (DUF2294)
E3T12_RS00785	COG1647	Serine aminopeptidase, S33
E3T12_RS00795	COG0733	neurotransmitter:sodium symporter activity
E3T12_RS00800	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E3T12_RS00815	COG2011	ABC-type metal ion transport system permease component
E3T12_RS00820	COG1464	Belongs to the NlpA lipoprotein family
E3T12_RS00855	COG0583	DNA-binding transcription factor activity
E3T12_RS00860	COG0069	glutamate synthase activity
E3T12_RS00860	COG0070	glutamate synthase
E3T12_RS00860	COG0067	glutamate synthase
E3T12_RS00865	COG0493	'glutamate synthase
E3T12_RS00875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3T12_RS00875	COG1263	PTS System
E3T12_RS00880	COG0366	Alpha amylase catalytic
E3T12_RS00885	COG2188	Transcriptional regulator
E3T12_RS00905	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E3T12_RS00910	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E3T12_RS00940	COG1982	Orn Lys Arg decarboxylase major
E3T12_RS00950	COG3870	Protein conserved in bacteria
E3T12_RS00955	COG0470	DNA polymerase III
E3T12_RS00960	COG1774	PSP1 C-terminal conserved region
E3T12_RS00970	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E3T12_RS00980	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E3T12_RS00990	COG0084	hydrolase, TatD family'
E3T12_RS00995	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
E3T12_RS01005	COG4466	Protein conserved in bacteria
E3T12_RS01015	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E3T12_RS01020	COG0251	oxidation-reduction process
E3T12_RS01060	COG2244	polysaccharide biosynthetic process
E3T12_RS01065	COG3956	TIGRFAM MazG family protein
E3T12_RS01070	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E3T12_RS01080	COG1098	S1 RNA binding domain
E3T12_RS01095	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E3T12_RS01120	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E3T12_RS01215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E3T12_RS01230	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E3T12_RS01240	COG3880	PFAM UvrB UvrC protein
E3T12_RS01255	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E3T12_RS01260	COG4956	integral membrane protein (PIN domain superfamily)
E3T12_RS01280	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
E3T12_RS01305	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E3T12_RS01310	COG0250	Participates in transcription elongation, termination and antitermination
E3T12_RS01340	COG2813	Specifically methylates the guanine in position
E3T12_RS01380	COG1473	amidohydrolase
E3T12_RS01410	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E3T12_RS01415	COG1428	Deoxynucleoside kinase
E3T12_RS01420	COG1428	Deoxynucleoside kinase
E3T12_RS01430	COG0561	phosphatase activity
E3T12_RS01465	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E3T12_RS01570	COG0095	Lipoate-protein ligase
E3T12_RS01575	COG0083	homoserine kinase activity
E3T12_RS01595	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3T12_RS01635	COG0667	Aldo Keto reductase
E3T12_RS01640	COG0655	NAD(P)H dehydrogenase (quinone) activity
E3T12_RS01650	COG1078	dGTPase activity
E3T12_RS01685	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E3T12_RS01785	COG2814	Major facilitator Superfamily
E3T12_RS01795	COG0803	Belongs to the bacterial solute-binding protein 9 family
E3T12_RS01800	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E3T12_RS01805	COG1121	(ABC) transporter
E3T12_RS01810	COG1321	iron dependent repressor
E3T12_RS01830	COG1682	transport, permease protein
E3T12_RS01835	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E3T12_RS01845	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E3T12_RS01850	COG1686	Belongs to the peptidase S11 family
E3T12_RS01855	COG1132	(ABC) transporter
E3T12_RS01860	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E3T12_RS01870	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E3T12_RS01875	COG1120	ATPase activity
E3T12_RS01880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3T12_RS01885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3T12_RS01890	COG2376	Dihydroxyacetone kinase
E3T12_RS01910	COG3949	Membrane
E3T12_RS01945	COG1136	(ABC) transporter
E3T12_RS01950	COG0577	efflux transmembrane transporter activity
E3T12_RS01955	COG1392	Phosphate transport regulator
E3T12_RS01960	COG0306	phosphate transporter
E3T12_RS01965	COG1388	LysM domain
E3T12_RS01965	COG3942	CHAP domain
E3T12_RS01975	COG1917	Cupin 2, conserved barrel domain protein
E3T12_RS01975	COG4977	sequence-specific DNA binding
E3T12_RS02005	COG0583	DNA-binding transcription factor activity
E3T12_RS02010	COG2814	Major facilitator Superfamily
E3T12_RS02015	COG2839	Protein conserved in bacteria
E3T12_RS02025	COG3316	Transposase and inactivated derivatives
E3T12_RS02070	COG0577	efflux transmembrane transporter activity
E3T12_RS02070	COG1136	(ABC) transporter
E3T12_RS02140	COG0583	DNA-binding transcription factor activity
E3T12_RS02185	COG3316	Transposase and inactivated derivatives
E3T12_RS02220	COG1611	Belongs to the LOG family
E3T12_RS02240	COG4988	ABC transporter
E3T12_RS02245	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E3T12_RS02250	COG1846	Transcriptional regulator
E3T12_RS02255	COG0523	cobalamin synthesis protein
E3T12_RS02260	COG4989	oxidoreductase activity
E3T12_RS02270	COG0471	metal ion transport
E3T12_RS02305	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E3T12_RS02310	COG1349	DNA-binding transcription factor activity
E3T12_RS02315	COG1105	Belongs to the carbohydrate kinase PfkB family
E3T12_RS02320	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3T12_RS02320	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3T12_RS02320	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3T12_RS02325	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E3T12_RS02330	COG1253	flavin adenine dinucleotide binding
E3T12_RS02335	COG0656	L-ascorbic acid biosynthetic process
E3T12_RS02340	COG0463	Glycosyl transferase, family 2
E3T12_RS02375	COG0720	synthase
E3T12_RS02385	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E3T12_RS02385	COG0512	Glutamine amidotransferase of anthranilate synthase
E3T12_RS02390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E3T12_RS02420	COG0488	(ABC) transporter
E3T12_RS02425	COG0514	ATP-dependent DNA helicase (RecQ)
E3T12_RS02430	COG1125	glycine betaine transport
E3T12_RS02430	COG0517	IMP dehydrogenase activity
E3T12_RS02435	COG1174	glycine betaine transport
E3T12_RS02460	COG3104	oligopeptide transport
E3T12_RS02480	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E3T12_RS02485	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E3T12_RS02490	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3T12_RS02495	COG4605	iron ion homeostasis
E3T12_RS02500	COG4604	ABC transporter, ATP-binding protein
E3T12_RS02505	COG4607	ABC-type enterochelin transport system periplasmic component
E3T12_RS02560	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E3T12_RS02565	COG1739	Uncharacterized protein family UPF0029
E3T12_RS02575	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
E3T12_RS02580	COG1040	competence protein
E3T12_RS02605	COG3942	CHAP domain
E3T12_RS02605	COG1388	LysM domain
E3T12_RS02665	COG0391	Required for morphogenesis under gluconeogenic growth conditions
E3T12_RS02680	COG0281	malic enzyme
E3T12_RS02730	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E3T12_RS02735	COG1647	Serine aminopeptidase, S33
E3T12_RS02740	COG0557	exoribonuclease II activity
E3T12_RS02805	COG1278	Cold shock
E3T12_RS02845	COG0406	alpha-ribazole phosphatase activity
E3T12_RS02850	COG1279	arginine transmembrane transporter activity
E3T12_RS02875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E3T12_RS02880	COG1393	Belongs to the ArsC family
E3T12_RS02895	COG3878	Protein conserved in bacteria
E3T12_RS02900	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
E3T12_RS02915	COG2011	ABC-type metal ion transport system permease component
E3T12_RS02920	COG1464	Belongs to the NlpA lipoprotein family
E3T12_RS02935	COG0396	ATPase activity
E3T12_RS02940	COG0719	Fe-S assembly protein
E3T12_RS02950	COG0822	iron-sulfur transferase activity
E3T12_RS02970	COG1253	flavin adenine dinucleotide binding
E3T12_RS02980	COG1801	Protein of unknown function DUF72
E3T12_RS02985	COG0730	response to heat
E3T12_RS03000	COG4470	Protein conserved in bacteria
E3T12_RS03010	COG2445	Protein of unknown function DUF86
E3T12_RS03040	COG1696	Membrane protein involved in D-alanine export
E3T12_RS03050	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
E3T12_RS03055	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E3T12_RS03060	COG4837	Protein of unknown function (DUF1462)
E3T12_RS03065	COG1252	NADH dehydrogenase
E3T12_RS03075	COG0316	Belongs to the HesB IscA family
E3T12_RS03085	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E3T12_RS03090	COG2056	Na+-H+ antiporter family
E3T12_RS03095	COG2050	protein possibly involved in aromatic compounds catabolism
E3T12_RS03150	COG1098	S1 RNA binding domain
E3T12_RS03155	COG1902	pentaerythritol trinitrate reductase activity
E3T12_RS03170	COG0584	glycerophosphoryl diester phosphodiesterase
E3T12_RS03190	COG0398	Pfam SNARE associated Golgi protein
E3T12_RS03235	COG0561	phosphatase activity
E3T12_RS03275	COG1881	PFAM PEBP family protein
E3T12_RS03305	COG0601	transmembrane transport
E3T12_RS03310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3T12_RS03315	COG0444	Belongs to the ABC transporter superfamily
E3T12_RS03320	COG4608	Belongs to the ABC transporter superfamily
E3T12_RS03325	COG4166	transmembrane transport
E3T12_RS03335	COG2826	transposase and inactivated derivatives, IS30 family
E3T12_RS03340	COG0747	negative chemotaxis
E3T12_RS03345	COG0444	Belongs to the ABC transporter superfamily
E3T12_RS03350	COG4608	Belongs to the ABC transporter superfamily
E3T12_RS03360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3T12_RS03395	COG1164	Oligoendopeptidase f
E3T12_RS03405	COG2346	COG2346, Truncated hemoglobins
E3T12_RS03420	COG2357	RelA SpoT domain protein
E3T12_RS03430	COG0564	pseudouridine synthase activity
E3T12_RS03435	COG2239	Acts as a magnesium transporter
E3T12_RS03440	COG0569	domain protein
E3T12_RS03440	COG0475	glutathione-regulated potassium exporter activity
E3T12_RS03450	COG0628	permease
E3T12_RS03455	COG1115	amino acid carrier protein
E3T12_RS03505	COG0861	Integral membrane protein TerC family
E3T12_RS03515	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E3T12_RS03520	COG0737	Belongs to the 5'-nucleotidase family
E3T12_RS03535	COG4903	ComK protein
E3T12_RS03550	COG4873	Protein conserved in bacteria
E3T12_RS03610	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
E3T12_RS03620	COG2314	TM2 domain
E3T12_RS03625	COG0456	acetyltransferase
E3T12_RS03630	COG1575	Belongs to the MenA family. Type 1 subfamily
E3T12_RS03640	COG1169	isochorismate synthase
E3T12_RS03650	COG2267	carboxylic ester hydrolase activity
E3T12_RS03675	COG0436	Aminotransferase
E3T12_RS03680	COG3594	Acyltransferase
E3T12_RS03710	COG1316	TRANSCRIPTIONal
E3T12_RS03755	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E3T12_RS03770	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E3T12_RS03810	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
E3T12_RS03815	COG4172	Belongs to the ABC transporter superfamily
E3T12_RS03820	COG4721	ABC-type cobalt transport system, permease component
E3T12_RS03835	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E3T12_RS03860	COG1271	oxidase subunit
E3T12_RS03865	COG1294	oxidase, subunit
E3T12_RS03870	COG0569	domain protein
E3T12_RS03935	COG1176	ABC-type spermidine putrescine transport system, permease component I
E3T12_RS03940	COG1177	transmembrane transport
E3T12_RS03945	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E3T12_RS03970	COG0483	inositol monophosphate 1-phosphatase activity
E3T12_RS03990	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E3T12_RS04000	COG0772	Belongs to the SEDS family
E3T12_RS04005	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
E3T12_RS04025	COG2340	Cysteine-rich secretory protein family
E3T12_RS04030	COG3679	Belongs to the UPF0342 family
E3T12_RS04035	COG0584	glycerophosphoryl diester phosphodiesterase
E3T12_RS04050	COG0742	ribosomal rna small subunit methyltransferase
E3T12_RS04105	COG4509	Sortase family
E3T12_RS04120	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E3T12_RS04150	COG1796	DNA polymerase
E3T12_RS04150	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E3T12_RS04175	COG2009	succinate dehydrogenase
E3T12_RS04180	COG1053	succinate dehydrogenase
E3T12_RS04185	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E3T12_RS04295	COG1288	antiporter activity
E3T12_RS04325	COG1011	Hydrolase
E3T12_RS04350	COG4839	cell division protein FtsL
E3T12_RS04380	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E3T12_RS04390	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E3T12_RS04400	COG0762	integral membrane protein
E3T12_RS04405	COG2302	S4 RNA-binding domain
E3T12_RS04410	COG3599	regulation of cell shape
E3T12_RS04420	COG2826	transposase and inactivated derivatives, IS30 family
E3T12_RS04425	COG2514	catechol 2,3-dioxygenase activity
E3T12_RS04435	COG0564	pseudouridine synthase activity
E3T12_RS04445	COG2233	PERMEase
E3T12_RS04505	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E3T12_RS04510	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E3T12_RS04520	COG2314	TM2 domain
E3T12_RS04535	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E3T12_RS04535	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E3T12_RS04545	COG0631	protein serine/threonine phosphatase activity
E3T12_RS04560	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E3T12_RS04575	COG1302	Protein conserved in bacteria
E3T12_RS04620	COG1196	nuclear chromosome segregation
E3T12_RS04625	COG0552	protein localization to endoplasmic reticulum
E3T12_RS04635	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E3T12_RS04690	COG2348	transferase activity, transferring amino-acyl groups
E3T12_RS04695	COG0758	DNA mediated transformation
E3T12_RS04790	COG0195	Participates in both transcription termination and antitermination
E3T12_RS04795	COG2740	Nucleic-acid-binding protein implicated in transcription termination
E3T12_RS04820	COG0196	riboflavin kinase activity
E3T12_RS04845	COG2188	Transcriptional regulator
E3T12_RS04850	COG0612	Peptidase, M16
E3T12_RS04855	COG0612	Peptidase, M16
E3T12_RS04860	COG0300	oxidoreductase activity
E3T12_RS04880	COG1546	Belongs to the CinA family
E3T12_RS04880	COG1058	Belongs to the CinA family
E3T12_RS04900	COG1692	metallophosphoesterase
E3T12_RS04905	COG0674	pyruvate-flavodoxin oxidoreductase activity
E3T12_RS04905	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E3T12_RS04910	COG1013	pyruvate-flavodoxin oxidoreductase activity
E3T12_RS04945	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
E3T12_RS04950	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E3T12_RS04975	COG1923	regulation of RNA biosynthetic process
E3T12_RS04990	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
E3T12_RS04995	COG0789	Transcriptional regulator
E3T12_RS05010	COG2826	transposase and inactivated derivatives, IS30 family
E3T12_RS05040	COG1674	ftsk spoiiie
E3T12_RS05045	COG0433	COG0433 Predicted ATPase
E3T12_RS05105	COG2826	transposase and inactivated derivatives, IS30 family
E3T12_RS05205	COG1131	(ABC) transporter
E3T12_RS05220	COG2197	response regulator
E3T12_RS05230	COG1525	nuclease
E3T12_RS05245	COG0527	aspartate kinase activity
E3T12_RS05250	COG0460	homoserine dehydrogenase
E3T12_RS05255	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E3T12_RS05285	COG0833	amino acid
E3T12_RS05350	COG4846	Membrane protein involved in cytochrome C biogenesis
E3T12_RS05370	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E3T12_RS05380	COG0824	Thioesterase
E3T12_RS05395	COG0187	DNA topoisomerase II activity
E3T12_RS05405	COG1115	amino acid carrier protein
E3T12_RS05420	COG0628	permease
E3T12_RS05430	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E3T12_RS05435	COG1316	TRANSCRIPTIONal
E3T12_RS05450	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E3T12_RS05460	COG1363	Peptidase, m42
E3T12_RS05465	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E3T12_RS05470	COG0512	Glutamine amidotransferase of anthranilate synthase
E3T12_RS05505	COG2348	transferase activity, transferring amino-acyl groups
E3T12_RS05555	COG0704	Plays a role in the regulation of phosphate uptake
E3T12_RS05565	COG0581	inorganic phosphate transmembrane transporter activity
E3T12_RS05570	COG0573	inorganic phosphate transmembrane transporter activity
E3T12_RS05585	COG0488	(ABC) transporter
E3T12_RS05590	COG0527	aspartate kinase activity
E3T12_RS05595	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E3T12_RS05665	COG4548	von Willebrand factor, type A
E3T12_RS05715	COG0671	phosphoesterase, PA-phosphatase related
E3T12_RS05735	COG2826	transposase and inactivated derivatives, IS30 family
E3T12_RS05795	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E3T12_RS05815	COG0531	amino acid
E3T12_RS05830	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E3T12_RS05835	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
E3T12_RS05850	COG0116	Belongs to the methyltransferase superfamily
E3T12_RS05880	COG4499	WXG100 protein secretion system (Wss), protein YukC
E3T12_RS05880	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E3T12_RS05890	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E3T12_RS05895	COG3935	DnaD domain protein
E3T12_RS05920	COG0438	transferase activity, transferring glycosyl groups
E3T12_RS05925	COG1694	Mazg nucleotide pyrophosphohydrolase
E3T12_RS05930	COG2738	Putative neutral zinc metallopeptidase
E3T12_RS05935	COG4347	Protein of unknown function (DUF1405)
E3T12_RS05970	COG0142	geranyltranstransferase activity
E3T12_RS06025	COG0492	ferredoxin-NADP+ reductase activity
E3T12_RS06040	COG0514	ATP-dependent DNA helicase (RecQ)
E3T12_RS06050	COG1141	Ferredoxin
E3T12_RS06095	COG0745	RESPONSE REGULATOR receiver
E3T12_RS06100	COG1187	pseudouridine synthase activity
E3T12_RS06125	COG0735	belongs to the Fur family
E3T12_RS06130	COG0494	nUDIX hydrolase
E3T12_RS06135	COG0667	Aldo Keto reductase
E3T12_RS06145	COG4221	oxidoreductase activity
E3T12_RS06160	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E3T12_RS06170	COG0366	Alpha amylase catalytic
E3T12_RS06175	COG1609	Transcriptional regulator
E3T12_RS06205	COG2195	Cleaves the N-terminal amino acid of tripeptides
E3T12_RS06215	COG4129	membrane
E3T12_RS06225	COG0508	dehydrogenase complex catalyzes the overall conversion of
E3T12_RS06230	COG0022	dehydrogenase e1 component
E3T12_RS06235	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E3T12_RS06240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3T12_RS06245	COG0497	DNA recombination
E3T12_RS06275	COG1302	Protein conserved in bacteria
E3T12_RS06280	COG0439	Biotin carboxylase
E3T12_RS06285	COG0511	ligase activity, forming carbon-carbon bonds
E3T12_RS06295	COG0006	proline dipeptidase activity
E3T12_RS06310	COG0095	Lipoate-protein ligase
E3T12_RS06315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E3T12_RS06360	COG4537	Required for transformation and DNA binding
E3T12_RS06365	COG1459	type II secretion system
E3T12_RS06370	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E3T12_RS06375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E3T12_RS06380	COG0011	TIGRFAM Protein of
E3T12_RS06385	COG1940	carbohydrate kinase activity
E3T12_RS06390	COG4483	Protein conserved in bacteria
E3T12_RS06400	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E3T12_RS06420	COG0735	belongs to the Fur family
E3T12_RS06425	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E3T12_RS06430	COG1121	(ABC) transporter
E3T12_RS06440	COG0513	Belongs to the DEAD box helicase family
E3T12_RS06450	COG2384	SAM-dependent methyltransferase
E3T12_RS06455	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E3T12_RS06470	COG0517	IMP dehydrogenase activity
E3T12_RS06490	COG0295	cytidine deaminase activity
E3T12_RS06505	COG1702	phosphate starvation-inducible protein PhoH
E3T12_RS06520	COG1030	water channel activity
E3T12_RS06530	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E3T12_RS06535	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E3T12_RS06565	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E3T12_RS06580	COG1466	dna polymerase III delta subunit
E3T12_RS06585	COG2333	competence protein COMEC
E3T12_RS06585	COG0658	competence protein
E3T12_RS06590	COG2131	deaminase
E3T12_RS06600	COG2226	methyltransferase
E3T12_RS06605	COG0799	negative regulation of ribosome biogenesis
E3T12_RS06610	COG1713	HD superfamily hydrolase involved in NAD metabolism
E3T12_RS06620	COG1534	Rna-binding protein
E3T12_RS06630	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
E3T12_RS06635	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
E3T12_RS06660	COG1914	H( )-stimulated, divalent metal cation uptake system
E3T12_RS06670	COG0439	Biotin carboxylase
E3T12_RS06675	COG0511	ligase activity, forming carbon-carbon bonds
E3T12_RS06680	COG1984	allophanate hydrolase subunit 2
E3T12_RS06685	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E3T12_RS06735	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E3T12_RS06750	COG1104	cysteine desulfurase activity
E3T12_RS06755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E3T12_RS06770	COG1959	2 iron, 2 sulfur cluster binding
E3T12_RS06775	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E3T12_RS06780	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E3T12_RS06825	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E3T12_RS06825	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E3T12_RS06830	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E3T12_RS06830	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E3T12_RS06835	COG1862	Preprotein translocase
E3T12_RS06875	COG2868	ribosomal protein
E3T12_RS06920	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
E3T12_RS06925	COG0285	dihydrofolate synthase activity
E3T12_RS06935	COG2818	Glycosylase
E3T12_RS06955	COG0113	porphobilinogen synthase activity
E3T12_RS06970	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E3T12_RS07005	COG4112	unkown
E3T12_RS07025	COG0833	amino acid
E3T12_RS07040	COG1484	DNA-dependent DNA replication
E3T12_RS07065	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E3T12_RS07070	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E3T12_RS07070	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E3T12_RS07080	COG5002	protein histidine kinase activity
E3T12_RS07085	COG0745	RESPONSE REGULATOR receiver
E3T12_RS07095	COG0372	Belongs to the citrate synthase family
E3T12_RS07100	COG1113	amino acid transport
E3T12_RS07125	COG0281	malic enzyme
E3T12_RS07135	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E3T12_RS07140	COG4109	DRTGG domain
E3T12_RS07180	COG0827	DNA restriction-modification system
E3T12_RS07190	COG0730	response to heat
E3T12_RS07200	COG1104	cysteine desulfurase activity
E3T12_RS07215	COG1956	GAF domain-containing protein
E3T12_RS07230	COG0584	glycerophosphoryl diester phosphodiesterase
E3T12_RS07235	COG1764	response to oxidative stress
E3T12_RS07240	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E3T12_RS07245	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E3T12_RS07260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3T12_RS07260	COG1263	PTS System
E3T12_RS07265	COG0204	Acyl-transferase
E3T12_RS07270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E3T12_RS07300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E3T12_RS07305	COG0454	-acetyltransferase
E3T12_RS07325	COG1605	Chorismate mutase
E3T12_RS07325	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
E3T12_RS07350	COG1674	ftsk spoiiie
E3T12_RS07355	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E3T12_RS07365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E3T12_RS07370	COG1363	Peptidase, m42
E3T12_RS07380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E3T12_RS07420	COG0510	thiamine kinase activity
E3T12_RS07440	COG1187	pseudouridine synthase activity
E3T12_RS07445	COG2244	polysaccharide biosynthetic process
E3T12_RS07450	COG2081	HI0933 family
E3T12_RS07470	COG2814	Major facilitator Superfamily
E3T12_RS07475	COG1242	4 iron, 4 sulfur cluster binding
E3T12_RS07480	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
E3T12_RS07485	COG1846	Transcriptional regulator
E3T12_RS07490	COG2267	carboxylic ester hydrolase activity
E3T12_RS07520	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E3T12_RS07520	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E3T12_RS07540	COG3266	domain, Protein
E3T12_RS07540	COG4193	domain, Protein
E3T12_RS07540	COG5632	N-Acetylmuramoyl-L-alanine amidase
E3T12_RS07575	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E3T12_RS07585	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E3T12_RS07595	COG0656	L-ascorbic acid biosynthetic process
E3T12_RS07615	COG1506	peptidase
E3T12_RS07620	COG2816	NAD+ diphosphatase activity
E3T12_RS07710	COG5492	domain, Protein
E3T12_RS07920	COG1131	(ABC) transporter
E3T12_RS07925	COG0537	adenosine 5'-monophosphoramidase activity
E3T12_RS07955	COG0420	3'-5' exonuclease activity
E3T12_RS07975	COG2197	response regulator
E3T12_RS07980	COG2203	Gaf domain
E3T12_RS07980	COG4585	Histidine kinase
E3T12_RS07985	COG0564	pseudouridine synthase activity
E3T12_RS08015	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E3T12_RS08020	COG1126	abc transporter atp-binding protein
E3T12_RS08025	COG0765	amino acid transport
E3T12_RS08190	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E3T12_RS08195	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E3T12_RS08205	COG4129	membrane
E3T12_RS08220	COG1194	a g-specific adenine glycosylase
E3T12_RS08225	COG1988	membrane-bound metal-dependent
E3T12_RS08235	COG1388	LysM domain
E3T12_RS08235	COG1134	teichoic acid transport
E3T12_RS08275	COG5632	N-Acetylmuramoyl-L-alanine amidase
E3T12_RS08275	COG1388	LysM domain
E3T12_RS08475	COG1484	DNA-dependent DNA replication
E3T12_RS08550	COG1396	sequence-specific DNA binding
E3T12_RS08575	COG4974	Belongs to the 'phage' integrase family
E3T12_RS08580	COG0535	radical SAM domain protein
E3T12_RS08585	COG1607	acyl-coa hydrolase
E3T12_RS08590	COG2309	aminopeptidase activity
E3T12_RS08610	COG1295	ribonuclease BN
E3T12_RS08725	COG4851	CamS sex pheromone cAM373 precursor
E3T12_RS08745	COG4496	protein, YerC YecD
E3T12_RS08780	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E3T12_RS08790	COG0077	Prephenate dehydratase
E3T12_RS08810	COG1335	isochorismatase
E3T12_RS08825	COG1012	belongs to the aldehyde dehydrogenase family
E3T12_RS08875	COG1131	(ABC) transporter
E3T12_RS08890	COG1725	Transcriptional regulator
E3T12_RS08945	COG0860	N-Acetylmuramoyl-L-alanine amidase
E3T12_RS08945	COG1388	LysM domain
E3T12_RS08955	COG5632	N-Acetylmuramoyl-L-alanine amidase
E3T12_RS08955	COG1388	LysM domain
E3T12_RS09005	COG0739	heme binding
E3T12_RS09055	COG0740	serine-type endopeptidase activity
E3T12_RS09225	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E3T12_RS09275	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E3T12_RS09350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3T12_RS09355	COG1621	beta-fructofuranosidase activity
E3T12_RS09360	COG1609	Transcriptional regulator
E3T12_RS09365	COG0004	ammonium transporteR
E3T12_RS09370	COG0425	Belongs to the sulfur carrier protein TusA family
E3T12_RS09375	COG2391	methyltransferase activity
E3T12_RS09385	COG0488	(ABC) transporter
E3T12_RS09395	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E3T12_RS09405	COG0456	acetyltransferase
E3T12_RS09410	COG1214	PFAM Peptidase M22, glycoprotease
E3T12_RS09415	COG0802	atpase or kinase
E3T12_RS09430	COG0028	Belongs to the TPP enzyme family
E3T12_RS09505	COG2183	response to ionizing radiation
E3T12_RS09510	COG1191	sigma factor activity
E3T12_RS09520	COG1366	Belongs to the anti-sigma-factor antagonist family
E3T12_RS09525	COG2208	phosphoserine phosphatase activity
E3T12_RS09555	COG3428	Bacterial PH domain
E3T12_RS09585	COG2205	protein histidine kinase activity
E3T12_RS09590	COG0745	RESPONSE REGULATOR receiver
E3T12_RS09600	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E3T12_RS09610	COG0772	Belongs to the SEDS family
E3T12_RS09630	COG1937	Protein conserved in bacteria
E3T12_RS09640	COG1418	mRNA catabolic process
E3T12_RS09685	COG0629	single-stranded DNA binding
E3T12_RS09755	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E3T12_RS09780	COG0009	L-threonylcarbamoyladenylate synthase
E3T12_RS09785	COG2890	protein-(glutamine-N5) methyltransferase activity
E3T12_RS09805	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E3T12_RS09845	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E3T12_RS09890	COG0813	purine-nucleoside phosphorylase activity
E3T12_RS09895	COG0783	Belongs to the Dps family
E3T12_RS09915	COG1482	cell wall glycoprotein biosynthetic process
E3T12_RS09920	COG0702	epimerase
E3T12_RS09925	COG0640	Transcriptional regulator
E3T12_RS09955	COG0561	phosphatase activity
E3T12_RS09960	COG1119	ATPase activity
E3T12_RS09975	COG3711	transcriptional antiterminator
E3T12_RS10005	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
E3T12_RS10065	COG0489	protein tyrosine kinase activity
E3T12_RS10085	COG1272	protein, Hemolysin III
E3T12_RS10095	COG1988	membrane-bound metal-dependent
E3T12_RS10110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3T12_RS10115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3T12_RS10120	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
E3T12_RS10130	COG3457	Alanine racemase
E3T12_RS10135	COG4264	IucA IucC family
E3T12_RS10140	COG2814	Major facilitator Superfamily
E3T12_RS10165	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E3T12_RS10175	COG2130	NADP-dependent
E3T12_RS10245	COG0656	L-ascorbic acid biosynthetic process
E3T12_RS10250	COG0789	Transcriptional regulator
E3T12_RS10260	COG5492	domain, Protein
E3T12_RS10280	COG3527	Alpha-acetolactate decarboxylase
E3T12_RS10285	COG0028	Belongs to the TPP enzyme family
E3T12_RS10380	COG0201	protein transport
E3T12_RS10495	COG2252	PERMEase
E3T12_RS10540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E3T12_RS10600	COG1763	Mo-molybdopterin cofactor biosynthetic process
E3T12_RS10620	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E3T12_RS10625	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
E3T12_RS10630	COG4149	molybdate abc transporter
E3T12_RS10635	COG0725	ABC transporter, periplasmic molybdate-binding protein
E3T12_RS10650	COG1268	BioY protein
E3T12_RS10665	COG1960	acyl-CoA dehydrogenase activity
E3T12_RS10670	COG4413	Urea transporter
E3T12_RS10740	COG1757	Na H antiporter
E3T12_RS10820	COG1113	amino acid transport
E3T12_RS10840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E3T12_RS10855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3T12_RS10855	COG1263	PTS System
E3T12_RS10860	COG1737	Transcriptional regulator
E3T12_RS10880	COG1028	Short-chain dehydrogenase reductase Sdr
E3T12_RS10900	COG0583	DNA-binding transcription factor activity
E3T12_RS10925	COG2258	MOSC domain
E3T12_RS10945	COG1668	transmembrane transport
E3T12_RS10950	COG4152	abc transporter atp-binding protein
E3T12_RS10965	COG0786	glutamate:sodium symporter activity
E3T12_RS10975	COG0598	Magnesium transport protein CorA
E3T12_RS10990	COG0657	acetylesterase activity
E3T12_RS11000	COG2814	Major facilitator Superfamily
E3T12_RS11005	COG1566	PFAM secretion protein HlyD family protein
E3T12_RS11020	COG2814	Major facilitator Superfamily
E3T12_RS11080	COG1131	(ABC) transporter
E3T12_RS11095	COG1620	l-lactate permease
E3T12_RS11115	COG0604	alcohol dehydrogenase
E3T12_RS11140	COG1511	domain protein
E3T12_RS11155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3T12_RS11155	COG1263	PTS System
E3T12_RS11170	COG3871	stress protein (general stress protein 26)
E3T12_RS11235	COG2181	nitrate reductase activity
E3T12_RS11245	COG1140	nitrate reductase beta subunit
E3T12_RS11250	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
E3T12_RS11260	COG2146	nitrite reductase [NAD(P)H] activity
E3T12_RS11265	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E3T12_RS11275	COG0454	-acetyltransferase
E3T12_RS11280	COG2116	formate transmembrane transporter activity
E3T12_RS11295	COG3443	Belongs to the bacterial solute-binding protein 9 family
E3T12_RS11295	COG0803	Belongs to the bacterial solute-binding protein 9 family
E3T12_RS11330	COG1126	abc transporter atp-binding protein
E3T12_RS11335	COG0765	amino acid transport
E3T12_RS11340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3T12_RS11360	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E3T12_RS11400	COG0156	8-amino-7-oxononanoate synthase activity
E3T12_RS11410	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E3T12_RS11415	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E3T12_RS11425	COG1132	(ABC) transporter
E3T12_RS11445	COG1929	Belongs to the glycerate kinase type-1 family
E3T12_RS11455	COG2814	Major facilitator Superfamily
E3T12_RS11475	COG1113	amino acid transport
E3T12_RS11485	COG0531	amino acid
E3T12_RS11500	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E3T12_RS11510	COG1174	glycine betaine transport
E3T12_RS11520	COG1174	glycine betaine transport
E3T12_RS11540	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
E3T12_RS11545	COG0531	amino acid
E3T12_RS11550	COG2272	Belongs to the type-B carboxylesterase lipase family
E3T12_RS11555	COG2814	Major facilitator Superfamily
E3T12_RS11560	COG0390	transport system, permease component
E3T12_RS11565	COG4619	ABC transporter
E3T12_RS11570	COG1363	Peptidase, m42
E3T12_RS11575	COG4808	Protein conserved in bacteria
E3T12_RS11580	COG0069	glutamate synthase activity
E3T12_RS11595	COG1124	(ABC) transporter
E3T12_RS11605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3T12_RS11610	COG0601	transmembrane transport
E3T12_RS11615	COG0747	negative chemotaxis
E3T12_RS11635	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E3T12_RS11640	COG1028	Short-chain dehydrogenase reductase Sdr
E3T12_RS11645	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
E3T12_RS11650	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E3T12_RS11725	COG0494	nUDIX hydrolase
E3T12_RS11770	COG1070	Carbohydrate kinase
E3T12_RS11775	COG1802	Transcriptional regulator
E3T12_RS11780	COG0789	Transcriptional regulator
E3T12_RS11785	COG2357	RelA SpoT domain protein
E3T12_RS11790	COG4876	unkown
E3T12_RS11800	COG2271	Major facilitator Superfamily
E3T12_RS11805	COG0586	Pfam SNARE associated Golgi protein
E3T12_RS11810	COG1279	arginine transmembrane transporter activity
E3T12_RS11820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E3T12_RS11825	COG1131	(ABC) transporter
E3T12_RS11845	COG0400	carboxylic ester hydrolase activity
E3T12_RS11850	COG0346	lactoylglutathione lyase activity
E3T12_RS11855	COG1846	Transcriptional regulator
E3T12_RS11865	COG2514	catechol 2,3-dioxygenase activity
E3T12_RS11885	COG0561	phosphatase activity
E3T12_RS11890	COG3764	Sortase (surface protein transpeptidase)
E3T12_RS11910	COG1760	l-serine dehydratase
E3T12_RS11915	COG1760	l-serine dehydratase
E3T12_RS11930	COG0697	spore germination
E3T12_RS11935	COG0657	acetylesterase activity
E3T12_RS11955	COG0028	Belongs to the TPP enzyme family
E3T12_RS11970	COG0583	DNA-binding transcription factor activity
E3T12_RS11980	COG3942	CHAP domain
E3T12_RS11990	COG3425	synthase
E3T12_RS11995	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E3T12_RS12020	COG2409	Drug exporters of the RND superfamily
E3T12_RS12075	COG0436	Aminotransferase
E3T12_RS12215	COG0167	dihydroorotate dehydrogenase activity
E3T12_RS12265	COG3527	Alpha-acetolactate decarboxylase
E3T12_RS12275	COG0531	amino acid
E3T12_RS12305	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E3T12_RS12335	COG1510	regulation of RNA biosynthetic process
E3T12_RS12340	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E3T12_RS12365	COG2851	Citrate transporter
E3T12_RS12380	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E3T12_RS12390	COG0386	Belongs to the glutathione peroxidase family
E3T12_RS12410	COG1136	(ABC) transporter
E3T12_RS12415	COG2205	protein histidine kinase activity
E3T12_RS12420	COG0745	RESPONSE REGULATOR receiver
E3T12_RS12430	COG1785	Belongs to the alkaline phosphatase family
E3T12_RS12440	COG1846	Transcriptional regulator
E3T12_RS12485	COG1438	arginine binding
E3T12_RS12505	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3T12_RS12505	COG3711	transcriptional antiterminator
E3T12_RS12510	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3T12_RS12510	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3T12_RS12510	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3T12_RS12515	COG1482	cell wall glycoprotein biosynthetic process
E3T12_RS12525	COG3942	CHAP domain
E3T12_RS12525	COG1705	Flagellar rod assembly protein muramidase FlgJ
E3T12_RS12535	COG1535	isochorismatase
E3T12_RS12535	COG3433	isochorismatase activity
E3T12_RS12550	COG0438	transferase activity, transferring glycosyl groups
E3T12_RS12565	COG1073	alpha beta
E3T12_RS12575	COG0201	protein transport
E3T12_RS12585	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E3T12_RS12610	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E3T12_RS12640	COG1309	transcriptional regulator
E3T12_RS12695	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E3T12_RS12775	COG0471	metal ion transport
E3T12_RS12780	COG2962	Rard protein
E3T12_RS12790	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
E3T12_RS12805	COG1136	(ABC) transporter
E3T12_RS12810	COG0577	efflux transmembrane transporter activity
E3T12_RS12840	COG1278	Cold shock
E3T12_RS12860	COG1475	DNA binding
E3T12_RS12900	COG2501	S4 domain
E3T12_RS12920	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E3T12_RS12945	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E3T12_RS12955	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
E3T12_RS12965	COG0305	Participates in initiation and elongation during chromosome replication
E3T12_RS12995	COG4863	YycH protein
E3T12_RS13005	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E3T12_RS13010	COG0737	Belongs to the 5'-nucleotidase family
E3T12_RS13035	COG2826	transposase and inactivated derivatives, IS30 family
E3T12_RS13045	COG1401	restriction endodeoxyribonuclease activity
E3T12_RS13050	COG4268	DNA restriction-modification system
E3T12_RS13070	COG2814	Major facilitator Superfamily
E3T12_RS13090	COG0456	acetyltransferase
E3T12_RS13125	COG0823	Involved in the tonB-independent uptake of proteins
E3T12_RS13140	COG1473	amidohydrolase
E3T12_RS13150	COG1283	sodium-dependent phosphate transmembrane transporter activity
E3T12_RS13155	COG4716	Myosin-crossreactive antigen
E3T12_RS13165	COG1620	l-lactate permease
E3T12_RS13180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3T12_RS13185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3T12_RS13190	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E3T12_RS13200	COG2423	ornithine cyclodeaminase activity
E3T12_RS13205	COG4264	IucA IucC family
E3T12_RS13210	COG2814	Major facilitator Superfamily
E3T12_RS13215	COG4264	IucA IucC family
E3T12_RS13220	COG4264	IucA IucC family
E3T12_RS13230	COG0019	diaminopimelate decarboxylase activity
E3T12_RS13235	COG1475	DNA binding
E3T12_RS13255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3T12_RS13260	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E3T12_RS13265	COG0438	transferase activity, transferring glycosyl groups
E3T12_RS13295	COG0813	purine-nucleoside phosphorylase activity
E3T12_RS13300	COG2814	Major facilitator Superfamily
E3T12_RS13320	COG3639	organic phosphonate transmembrane transporter activity
E3T12_RS13340	COG0737	Belongs to the 5'-nucleotidase family
E3T12_RS13355	COG1012	belongs to the aldehyde dehydrogenase family
E3T12_RS13355	COG1454	alcohol dehydrogenase
E3T12_RS13385	COG1086	Polysaccharide biosynthesis protein
E3T12_RS13395	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E3T12_RS13425	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E3T12_RS13435	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E3T12_RS13440	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E3T12_RS13450	COG2832	Protein of unknown function (DUF454)
E3T12_RS13485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E3T12_RS13490	COG1960	acyl-CoA dehydrogenase activity
E3T12_RS13495	COG5609	conserved protein (DUF2294)
E3T12_RS13545	COG1114	Component of the transport system for branched-chain amino acids
E3T12_RS13550	COG1335	isochorismatase
E3T12_RS13555	COG3961	Belongs to the TPP enzyme family
E3T12_RS13585	COG1737	Transcriptional regulator
E3T12_RS13615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3T12_RS13625	COG0405	Gamma-glutamyltransferase
E3T12_RS13640	COG3842	ATPase activity
E3T12_RS13650	COG1175	transmembrane transport
E3T12_RS13655	COG3833	ABC-type maltose transport systems, permease component
E3T12_RS13660	COG0673	inositol 2-dehydrogenase activity
E3T12_RS13665	COG0673	inositol 2-dehydrogenase activity
E3T12_RS13675	COG1755	Isoprenylcysteine carboxyl methyltransferase
E3T12_RS13730	COG0183	Belongs to the thiolase family
E3T12_RS13740	COG1960	acyl-CoA dehydrogenase activity
E3T12_RS13745	COG0318	PFAM AMP-dependent synthetase and ligase
E3T12_RS13765	COG0747	negative chemotaxis
E3T12_RS13795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3T12_RS13795	COG2190	(PTS) system
E3T12_RS13795	COG1263	PTS System
E3T12_RS13800	COG1957	nucleoside hydrolase
E3T12_RS13820	COG3414	Phosphotransferase system galactitol-specific IIB component
E3T12_RS13825	COG3775	system Galactitol-specific IIC component
E3T12_RS13830	COG1063	alcohol dehydrogenase
E3T12_RS13840	COG1063	alcohol dehydrogenase
E3T12_RS13850	COG1063	alcohol dehydrogenase
E3T12_RS13855	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E3T12_RS13860	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E3T12_RS13870	COG1063	alcohol dehydrogenase
E3T12_RS13875	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E3T12_RS13915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E3T12_RS13920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3T12_RS13920	COG2190	(PTS) system
E3T12_RS13920	COG1263	PTS System
E3T12_RS13925	COG2723	6-phospho-beta-galactosidase activity
E3T12_RS13930	COG2226	methyltransferase
E3T12_RS14005	COG3942	CHAP domain
E3T12_RS14005	COG1388	LysM domain
E3T12_RS14115	COG1114	Component of the transport system for branched-chain amino acids
E3T12_RS14120	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
E3T12_RS14125	COG0577	efflux transmembrane transporter activity
E3T12_RS14155	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E3T12_RS14160	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E3T12_RS14195	COG0582	viral genome integration into host DNA
E3T12_RS14240	COG3645	SOS response
E3T12_RS14240	COG3646	Phage regulatory protein
E3T12_RS14320	COG1484	DNA-dependent DNA replication