locus-tag	class	description
E3S78_RS00065	COG5280	Phage tail tape measure protein TP901
E3S78_RS00065	COG3953	SLT domain
E3S78_RS00115	COG1388	LysM domain
E3S78_RS00115	COG0860	N-Acetylmuramoyl-L-alanine amidase
E3S78_RS00145	COG1141	Ferredoxin
E3S78_RS00155	COG0514	ATP-dependent DNA helicase (RecQ)
E3S78_RS00170	COG0492	ferredoxin-NADP+ reductase activity
E3S78_RS00225	COG0142	geranyltranstransferase activity
E3S78_RS00260	COG4347	Protein of unknown function (DUF1405)
E3S78_RS00265	COG2738	Putative neutral zinc metallopeptidase
E3S78_RS00270	COG1694	Mazg nucleotide pyrophosphohydrolase
E3S78_RS00275	COG0438	transferase activity, transferring glycosyl groups
E3S78_RS00300	COG3935	DnaD domain protein
E3S78_RS00305	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E3S78_RS00315	COG4499	WXG100 protein secretion system (Wss), protein YukC
E3S78_RS00315	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E3S78_RS00345	COG0116	Belongs to the methyltransferase superfamily
E3S78_RS00360	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
E3S78_RS00365	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E3S78_RS00380	COG0531	amino acid
E3S78_RS00400	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E3S78_RS00460	COG2826	transposase and inactivated derivatives, IS30 family
E3S78_RS00480	COG0671	phosphoesterase, PA-phosphatase related
E3S78_RS00530	COG4548	von Willebrand factor, type A
E3S78_RS00600	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E3S78_RS00605	COG0527	aspartate kinase activity
E3S78_RS00610	COG0488	(ABC) transporter
E3S78_RS00625	COG0573	inorganic phosphate transmembrane transporter activity
E3S78_RS00630	COG0581	inorganic phosphate transmembrane transporter activity
E3S78_RS00640	COG0704	Plays a role in the regulation of phosphate uptake
E3S78_RS00690	COG2348	transferase activity, transferring amino-acyl groups
E3S78_RS00725	COG0512	Glutamine amidotransferase of anthranilate synthase
E3S78_RS00730	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E3S78_RS00735	COG1363	Peptidase, m42
E3S78_RS00745	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E3S78_RS00760	COG1316	TRANSCRIPTIONal
E3S78_RS00765	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E3S78_RS00775	COG0628	permease
E3S78_RS00790	COG1115	amino acid carrier protein
E3S78_RS00800	COG0187	DNA topoisomerase II activity
E3S78_RS00815	COG0824	Thioesterase
E3S78_RS00825	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E3S78_RS00845	COG4846	Membrane protein involved in cytochrome C biogenesis
E3S78_RS00910	COG0833	amino acid
E3S78_RS00935	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E3S78_RS00940	COG0460	homoserine dehydrogenase
E3S78_RS00945	COG0527	aspartate kinase activity
E3S78_RS00960	COG1525	nuclease
E3S78_RS00970	COG2197	response regulator
E3S78_RS00985	COG1131	(ABC) transporter
E3S78_RS01100	COG2826	transposase and inactivated derivatives, IS30 family
E3S78_RS01140	COG2946	Replication initiation factor
E3S78_RS01160	COG0433	COG0433 Predicted ATPase
E3S78_RS01165	COG1674	ftsk spoiiie
E3S78_RS01195	COG2826	transposase and inactivated derivatives, IS30 family
E3S78_RS01210	COG0789	Transcriptional regulator
E3S78_RS01215	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
E3S78_RS01230	COG1923	regulation of RNA biosynthetic process
E3S78_RS01255	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E3S78_RS01260	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
E3S78_RS01295	COG1013	pyruvate-flavodoxin oxidoreductase activity
E3S78_RS01300	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E3S78_RS01300	COG0674	pyruvate-flavodoxin oxidoreductase activity
E3S78_RS01305	COG1692	metallophosphoesterase
E3S78_RS01325	COG1546	Belongs to the CinA family
E3S78_RS01325	COG1058	Belongs to the CinA family
E3S78_RS01345	COG0300	oxidoreductase activity
E3S78_RS01350	COG0612	Peptidase, M16
E3S78_RS01355	COG0612	Peptidase, M16
E3S78_RS01360	COG2188	Transcriptional regulator
E3S78_RS01385	COG0196	riboflavin kinase activity
E3S78_RS01410	COG2740	Nucleic-acid-binding protein implicated in transcription termination
E3S78_RS01415	COG0195	Participates in both transcription termination and antitermination
E3S78_RS01510	COG0758	DNA mediated transformation
E3S78_RS01570	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E3S78_RS01580	COG0552	protein localization to endoplasmic reticulum
E3S78_RS01585	COG1196	nuclear chromosome segregation
E3S78_RS01630	COG1302	Protein conserved in bacteria
E3S78_RS01645	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E3S78_RS01660	COG0631	protein serine/threonine phosphatase activity
E3S78_RS01670	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E3S78_RS01670	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E3S78_RS01685	COG2314	TM2 domain
E3S78_RS01695	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E3S78_RS01700	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E3S78_RS01760	COG2233	PERMEase
E3S78_RS01770	COG0564	pseudouridine synthase activity
E3S78_RS01780	COG2514	catechol 2,3-dioxygenase activity
E3S78_RS01795	COG3599	regulation of cell shape
E3S78_RS01800	COG2302	S4 RNA-binding domain
E3S78_RS01805	COG0762	integral membrane protein
E3S78_RS01815	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E3S78_RS01825	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E3S78_RS01855	COG4839	cell division protein FtsL
E3S78_RS01880	COG1011	Hydrolase
E3S78_RS01910	COG1288	antiporter activity
E3S78_RS02020	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E3S78_RS02025	COG1053	succinate dehydrogenase
E3S78_RS02030	COG2009	succinate dehydrogenase
E3S78_RS02055	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E3S78_RS02055	COG1796	DNA polymerase
E3S78_RS02085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E3S78_RS02100	COG4509	Sortase family
E3S78_RS02155	COG0742	ribosomal rna small subunit methyltransferase
E3S78_RS02170	COG0584	glycerophosphoryl diester phosphodiesterase
E3S78_RS02175	COG3679	Belongs to the UPF0342 family
E3S78_RS02180	COG2340	Cysteine-rich secretory protein family
E3S78_RS02200	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
E3S78_RS02205	COG0772	Belongs to the SEDS family
E3S78_RS02215	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E3S78_RS02235	COG0483	inositol monophosphate 1-phosphatase activity
E3S78_RS02260	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E3S78_RS02265	COG1177	transmembrane transport
E3S78_RS02270	COG1176	ABC-type spermidine putrescine transport system, permease component I
E3S78_RS02335	COG0569	domain protein
E3S78_RS02340	COG1294	oxidase, subunit
E3S78_RS02345	COG1271	oxidase subunit
E3S78_RS02370	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E3S78_RS02385	COG4721	ABC-type cobalt transport system, permease component
E3S78_RS02390	COG4172	Belongs to the ABC transporter superfamily
E3S78_RS02395	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
E3S78_RS02435	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E3S78_RS02450	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E3S78_RS02495	COG1316	TRANSCRIPTIONal
E3S78_RS02525	COG3594	Acyltransferase
E3S78_RS02530	COG0436	Aminotransferase
E3S78_RS02555	COG2267	carboxylic ester hydrolase activity
E3S78_RS02565	COG1169	isochorismate synthase
E3S78_RS02575	COG1575	Belongs to the MenA family. Type 1 subfamily
E3S78_RS02580	COG0456	acetyltransferase
E3S78_RS02585	COG2314	TM2 domain
E3S78_RS02595	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
E3S78_RS02655	COG4873	Protein conserved in bacteria
E3S78_RS02670	COG4903	ComK protein
E3S78_RS02685	COG0737	Belongs to the 5'-nucleotidase family
E3S78_RS02690	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E3S78_RS02700	COG0861	Integral membrane protein TerC family
E3S78_RS02750	COG1115	amino acid carrier protein
E3S78_RS02755	COG0628	permease
E3S78_RS02765	COG0569	domain protein
E3S78_RS02765	COG0475	glutathione-regulated potassium exporter activity
E3S78_RS02770	COG2239	Acts as a magnesium transporter
E3S78_RS02775	COG0564	pseudouridine synthase activity
E3S78_RS02785	COG2357	RelA SpoT domain protein
E3S78_RS02800	COG2346	COG2346, Truncated hemoglobins
E3S78_RS02810	COG1164	Oligoendopeptidase f
E3S78_RS02845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3S78_RS02855	COG4608	Belongs to the ABC transporter superfamily
E3S78_RS02860	COG0444	Belongs to the ABC transporter superfamily
E3S78_RS02865	COG0747	negative chemotaxis
E3S78_RS02870	COG2826	transposase and inactivated derivatives, IS30 family
E3S78_RS02880	COG4166	transmembrane transport
E3S78_RS02885	COG4608	Belongs to the ABC transporter superfamily
E3S78_RS02890	COG0444	Belongs to the ABC transporter superfamily
E3S78_RS02895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3S78_RS02900	COG0601	transmembrane transport
E3S78_RS02930	COG1881	PFAM PEBP family protein
E3S78_RS02970	COG0561	phosphatase activity
E3S78_RS03015	COG0398	Pfam SNARE associated Golgi protein
E3S78_RS03035	COG0584	glycerophosphoryl diester phosphodiesterase
E3S78_RS03050	COG1902	pentaerythritol trinitrate reductase activity
E3S78_RS03055	COG1098	S1 RNA binding domain
E3S78_RS03110	COG2050	protein possibly involved in aromatic compounds catabolism
E3S78_RS03115	COG2056	Na+-H+ antiporter family
E3S78_RS03120	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E3S78_RS03130	COG0316	Belongs to the HesB IscA family
E3S78_RS03140	COG1252	NADH dehydrogenase
E3S78_RS03145	COG4837	Protein of unknown function (DUF1462)
E3S78_RS03150	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E3S78_RS03155	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
E3S78_RS03165	COG1696	Membrane protein involved in D-alanine export
E3S78_RS03195	COG2445	Protein of unknown function DUF86
E3S78_RS03205	COG4470	Protein conserved in bacteria
E3S78_RS03220	COG0730	response to heat
E3S78_RS03225	COG1801	Protein of unknown function DUF72
E3S78_RS03235	COG1253	flavin adenine dinucleotide binding
E3S78_RS03260	COG0822	iron-sulfur transferase activity
E3S78_RS03270	COG0719	Fe-S assembly protein
E3S78_RS03275	COG0396	ATPase activity
E3S78_RS03290	COG1464	Belongs to the NlpA lipoprotein family
E3S78_RS03295	COG2011	ABC-type metal ion transport system permease component
E3S78_RS03310	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
E3S78_RS03315	COG3878	Protein conserved in bacteria
E3S78_RS03330	COG1393	Belongs to the ArsC family
E3S78_RS03335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E3S78_RS03360	COG1279	arginine transmembrane transporter activity
E3S78_RS03365	COG0406	alpha-ribazole phosphatase activity
E3S78_RS03405	COG1278	Cold shock
E3S78_RS03470	COG0557	exoribonuclease II activity
E3S78_RS03475	COG1647	Serine aminopeptidase, S33
E3S78_RS03480	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E3S78_RS03530	COG0281	malic enzyme
E3S78_RS03545	COG0391	Required for morphogenesis under gluconeogenic growth conditions
E3S78_RS03600	COG1388	LysM domain
E3S78_RS03600	COG3942	CHAP domain
E3S78_RS03625	COG1040	competence protein
E3S78_RS03640	COG1739	Uncharacterized protein family UPF0029
E3S78_RS03645	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E3S78_RS03700	COG4607	ABC-type enterochelin transport system periplasmic component
E3S78_RS03705	COG4604	ABC transporter, ATP-binding protein
E3S78_RS03710	COG4605	iron ion homeostasis
E3S78_RS03715	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3S78_RS03720	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E3S78_RS03725	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E3S78_RS03745	COG3104	oligopeptide transport
E3S78_RS03770	COG1174	glycine betaine transport
E3S78_RS03775	COG1125	glycine betaine transport
E3S78_RS03775	COG0517	IMP dehydrogenase activity
E3S78_RS03780	COG0514	ATP-dependent DNA helicase (RecQ)
E3S78_RS03785	COG0488	(ABC) transporter
E3S78_RS03815	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E3S78_RS03820	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E3S78_RS03820	COG0512	Glutamine amidotransferase of anthranilate synthase
E3S78_RS03830	COG0720	synthase
E3S78_RS03865	COG0463	Glycosyl transferase, family 2
E3S78_RS03870	COG0656	L-ascorbic acid biosynthetic process
E3S78_RS03875	COG1253	flavin adenine dinucleotide binding
E3S78_RS03880	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E3S78_RS03885	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3S78_RS03885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3S78_RS03885	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3S78_RS03890	COG1105	Belongs to the carbohydrate kinase PfkB family
E3S78_RS03895	COG1349	DNA-binding transcription factor activity
E3S78_RS03900	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E3S78_RS03935	COG0471	metal ion transport
E3S78_RS03945	COG4989	oxidoreductase activity
E3S78_RS03950	COG0523	cobalamin synthesis protein
E3S78_RS03955	COG1846	Transcriptional regulator
E3S78_RS03960	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E3S78_RS03965	COG4988	ABC transporter
E3S78_RS03985	COG1611	Belongs to the LOG family
E3S78_RS04020	COG3316	Transposase and inactivated derivatives
E3S78_RS04065	COG0583	DNA-binding transcription factor activity
E3S78_RS04135	COG1136	(ABC) transporter
E3S78_RS04135	COG0577	efflux transmembrane transporter activity
E3S78_RS04180	COG3316	Transposase and inactivated derivatives
E3S78_RS04190	COG2839	Protein conserved in bacteria
E3S78_RS04195	COG2814	Major facilitator Superfamily
E3S78_RS04200	COG0583	DNA-binding transcription factor activity
E3S78_RS04240	COG1388	LysM domain
E3S78_RS04240	COG3942	CHAP domain
E3S78_RS04245	COG0306	phosphate transporter
E3S78_RS04250	COG1392	Phosphate transport regulator
E3S78_RS04255	COG0577	efflux transmembrane transporter activity
E3S78_RS04260	COG1136	(ABC) transporter
E3S78_RS04295	COG3949	Membrane
E3S78_RS04315	COG2376	Dihydroxyacetone kinase
E3S78_RS04320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3S78_RS04325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3S78_RS04330	COG1120	ATPase activity
E3S78_RS04335	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E3S78_RS04345	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E3S78_RS04350	COG1132	(ABC) transporter
E3S78_RS04355	COG1686	Belongs to the peptidase S11 family
E3S78_RS04360	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E3S78_RS04370	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E3S78_RS04375	COG1682	transport, permease protein
E3S78_RS04395	COG1321	iron dependent repressor
E3S78_RS04400	COG1121	(ABC) transporter
E3S78_RS04405	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E3S78_RS04410	COG0803	Belongs to the bacterial solute-binding protein 9 family
E3S78_RS04420	COG2814	Major facilitator Superfamily
E3S78_RS04520	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E3S78_RS04555	COG1078	dGTPase activity
E3S78_RS04565	COG0655	NAD(P)H dehydrogenase (quinone) activity
E3S78_RS04570	COG0667	Aldo Keto reductase
E3S78_RS04610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3S78_RS04630	COG0083	homoserine kinase activity
E3S78_RS04635	COG0095	Lipoate-protein ligase
E3S78_RS04740	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E3S78_RS04765	COG4932	domain protein
E3S78_RS04780	COG0561	phosphatase activity
E3S78_RS04790	COG1428	Deoxynucleoside kinase
E3S78_RS04795	COG1428	Deoxynucleoside kinase
E3S78_RS04800	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E3S78_RS04830	COG1473	amidohydrolase
E3S78_RS04870	COG2813	Specifically methylates the guanine in position
E3S78_RS04900	COG0250	Participates in transcription elongation, termination and antitermination
E3S78_RS04905	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E3S78_RS04930	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
E3S78_RS04950	COG4956	integral membrane protein (PIN domain superfamily)
E3S78_RS04955	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E3S78_RS04970	COG3880	PFAM UvrB UvrC protein
E3S78_RS04980	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E3S78_RS04995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E3S78_RS05090	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E3S78_RS05115	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E3S78_RS05130	COG1098	S1 RNA binding domain
E3S78_RS05140	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E3S78_RS05145	COG3956	TIGRFAM MazG family protein
E3S78_RS05150	COG2244	polysaccharide biosynthetic process
E3S78_RS05190	COG0251	oxidation-reduction process
E3S78_RS05195	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E3S78_RS05205	COG4466	Protein conserved in bacteria
E3S78_RS05215	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
E3S78_RS05220	COG0084	hydrolase, TatD family'
E3S78_RS05230	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E3S78_RS05240	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E3S78_RS05250	COG1774	PSP1 C-terminal conserved region
E3S78_RS05255	COG0470	DNA polymerase III
E3S78_RS05260	COG3870	Protein conserved in bacteria
E3S78_RS05270	COG1982	Orn Lys Arg decarboxylase major
E3S78_RS05300	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E3S78_RS05305	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E3S78_RS05325	COG2188	Transcriptional regulator
E3S78_RS05330	COG0366	Alpha amylase catalytic
E3S78_RS05335	COG1263	PTS System
E3S78_RS05335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3S78_RS05345	COG0493	'glutamate synthase
E3S78_RS05350	COG0067	glutamate synthase
E3S78_RS05350	COG0069	glutamate synthase activity
E3S78_RS05350	COG0070	glutamate synthase
E3S78_RS05355	COG0583	DNA-binding transcription factor activity
E3S78_RS05390	COG1464	Belongs to the NlpA lipoprotein family
E3S78_RS05395	COG2011	ABC-type metal ion transport system permease component
E3S78_RS05405	COG0626	cystathionine gamma-synthase activity
E3S78_RS05410	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E3S78_RS05415	COG0733	neurotransmitter:sodium symporter activity
E3S78_RS05425	COG1647	Serine aminopeptidase, S33
E3S78_RS05440	COG5609	conserved protein (DUF2294)
E3S78_RS05450	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E3S78_RS05475	COG0523	cobalamin synthesis protein
E3S78_RS05610	COG3759	membrane
E3S78_RS05645	COG2233	PERMEase
E3S78_RS05675	COG1823	symporter activity
E3S78_RS05765	COG5484	DNA packaging
E3S78_RS05765	COG3728	DNA packaging
E3S78_RS05880	COG0012	GTP binding
E3S78_RS05885	COG4481	Protein conserved in bacteria
E3S78_RS05890	COG0668	transmembrane transport
E3S78_RS05895	COG1475	DNA binding
E3S78_RS05900	COG0626	cystathionine gamma-synthase activity
E3S78_RS05905	COG0626	cystathionine gamma-synthase activity
E3S78_RS05910	COG0646	methionine synthase
E3S78_RS05910	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E3S78_RS05940	COG1131	(ABC) transporter
E3S78_RS05950	COG1476	TRANSCRIPTIONal
E3S78_RS05960	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E3S78_RS05965	COG0805	protein transport
E3S78_RS05970	COG0672	)-iron permease
E3S78_RS05975	COG2837	iron assimilation
E3S78_RS05980	COG2822	iron ion transport
E3S78_RS05985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E3S78_RS06000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E3S78_RS06005	COG0346	lactoylglutathione lyase activity
E3S78_RS06010	COG2271	Major facilitator Superfamily
E3S78_RS06035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3S78_RS06045	COG3037	sugar-specific permease SgaT UlaA
E3S78_RS06075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E3S78_RS06125	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E3S78_RS06130	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E3S78_RS06160	COG0577	efflux transmembrane transporter activity
E3S78_RS06165	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
E3S78_RS06170	COG1114	Component of the transport system for branched-chain amino acids
E3S78_RS06280	COG3942	CHAP domain
E3S78_RS06280	COG1388	LysM domain
E3S78_RS06355	COG2226	methyltransferase
E3S78_RS06360	COG2723	6-phospho-beta-galactosidase activity
E3S78_RS06365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3S78_RS06365	COG1263	PTS System
E3S78_RS06365	COG2190	(PTS) system
E3S78_RS06370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E3S78_RS06410	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E3S78_RS06415	COG1063	alcohol dehydrogenase
E3S78_RS06425	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E3S78_RS06430	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E3S78_RS06435	COG1063	alcohol dehydrogenase
E3S78_RS06445	COG1063	alcohol dehydrogenase
E3S78_RS06455	COG1063	alcohol dehydrogenase
E3S78_RS06460	COG3775	system Galactitol-specific IIC component
E3S78_RS06465	COG3414	Phosphotransferase system galactitol-specific IIB component
E3S78_RS06485	COG1957	nucleoside hydrolase
E3S78_RS06490	COG1263	PTS System
E3S78_RS06490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3S78_RS06490	COG2190	(PTS) system
E3S78_RS06515	COG3189	MarR family transcriptional regulator
E3S78_RS06520	COG0747	negative chemotaxis
E3S78_RS06540	COG0318	PFAM AMP-dependent synthetase and ligase
E3S78_RS06545	COG1960	acyl-CoA dehydrogenase activity
E3S78_RS06555	COG0183	Belongs to the thiolase family
E3S78_RS06610	COG1755	Isoprenylcysteine carboxyl methyltransferase
E3S78_RS06620	COG0673	inositol 2-dehydrogenase activity
E3S78_RS06625	COG0673	inositol 2-dehydrogenase activity
E3S78_RS06630	COG3833	ABC-type maltose transport systems, permease component
E3S78_RS06635	COG1175	transmembrane transport
E3S78_RS06645	COG3842	ATPase activity
E3S78_RS06660	COG0405	Gamma-glutamyltransferase
E3S78_RS06670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3S78_RS06700	COG1737	Transcriptional regulator
E3S78_RS06730	COG3961	Belongs to the TPP enzyme family
E3S78_RS06735	COG1335	isochorismatase
E3S78_RS06740	COG1114	Component of the transport system for branched-chain amino acids
E3S78_RS06790	COG5609	conserved protein (DUF2294)
E3S78_RS06795	COG1960	acyl-CoA dehydrogenase activity
E3S78_RS06800	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E3S78_RS06835	COG2832	Protein of unknown function (DUF454)
E3S78_RS06845	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E3S78_RS06850	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E3S78_RS06860	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E3S78_RS06890	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E3S78_RS06900	COG1086	Polysaccharide biosynthesis protein
E3S78_RS06925	COG1012	belongs to the aldehyde dehydrogenase family
E3S78_RS06925	COG1454	alcohol dehydrogenase
E3S78_RS06940	COG0737	Belongs to the 5'-nucleotidase family
E3S78_RS06960	COG3639	organic phosphonate transmembrane transporter activity
E3S78_RS06980	COG2814	Major facilitator Superfamily
E3S78_RS06985	COG0813	purine-nucleoside phosphorylase activity
E3S78_RS07015	COG0438	transferase activity, transferring glycosyl groups
E3S78_RS07020	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E3S78_RS07025	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3S78_RS07045	COG1475	DNA binding
E3S78_RS07050	COG0019	diaminopimelate decarboxylase activity
E3S78_RS07060	COG4264	IucA IucC family
E3S78_RS07065	COG4264	IucA IucC family
E3S78_RS07070	COG2814	Major facilitator Superfamily
E3S78_RS07075	COG4264	IucA IucC family
E3S78_RS07080	COG2423	ornithine cyclodeaminase activity
E3S78_RS07090	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E3S78_RS07095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3S78_RS07100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3S78_RS07115	COG1620	l-lactate permease
E3S78_RS07125	COG4716	Myosin-crossreactive antigen
E3S78_RS07130	COG1283	sodium-dependent phosphate transmembrane transporter activity
E3S78_RS07135	COG2826	transposase and inactivated derivatives, IS30 family
E3S78_RS07145	COG1473	amidohydrolase
E3S78_RS07160	COG0823	Involved in the tonB-independent uptake of proteins
E3S78_RS07195	COG0456	acetyltransferase
E3S78_RS07215	COG2814	Major facilitator Superfamily
E3S78_RS07235	COG4268	DNA restriction-modification system
E3S78_RS07240	COG1401	restriction endodeoxyribonuclease activity
E3S78_RS07250	COG2826	transposase and inactivated derivatives, IS30 family
E3S78_RS07275	COG0737	Belongs to the 5'-nucleotidase family
E3S78_RS07280	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E3S78_RS07290	COG4863	YycH protein
E3S78_RS07320	COG0305	Participates in initiation and elongation during chromosome replication
E3S78_RS07330	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
E3S78_RS07340	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E3S78_RS07365	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E3S78_RS07385	COG2501	S4 domain
E3S78_RS07425	COG1475	DNA binding
E3S78_RS07445	COG1278	Cold shock
E3S78_RS07475	COG0577	efflux transmembrane transporter activity
E3S78_RS07480	COG1136	(ABC) transporter
E3S78_RS07495	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
E3S78_RS07505	COG2962	Rard protein
E3S78_RS07510	COG0471	metal ion transport
E3S78_RS07590	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E3S78_RS07640	COG1215	transferase activity, transferring glycosyl groups
E3S78_RS07645	COG1309	transcriptional regulator
E3S78_RS07675	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E3S78_RS07700	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E3S78_RS07710	COG0201	protein transport
E3S78_RS07725	COG1073	alpha beta
E3S78_RS07740	COG0438	transferase activity, transferring glycosyl groups
E3S78_RS07755	COG1535	isochorismatase
E3S78_RS07755	COG3433	isochorismatase activity
E3S78_RS07760	COG3942	CHAP domain
E3S78_RS07760	COG1705	Flagellar rod assembly protein muramidase FlgJ
E3S78_RS07770	COG1482	cell wall glycoprotein biosynthetic process
E3S78_RS07775	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3S78_RS07775	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3S78_RS07775	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3S78_RS07780	COG3711	transcriptional antiterminator
E3S78_RS07780	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3S78_RS07800	COG1438	arginine binding
E3S78_RS07845	COG1846	Transcriptional regulator
E3S78_RS07855	COG1785	Belongs to the alkaline phosphatase family
E3S78_RS07865	COG0745	RESPONSE REGULATOR receiver
E3S78_RS07870	COG2205	protein histidine kinase activity
E3S78_RS07875	COG1136	(ABC) transporter
E3S78_RS07895	COG0386	Belongs to the glutathione peroxidase family
E3S78_RS07905	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E3S78_RS07920	COG2851	Citrate transporter
E3S78_RS07945	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E3S78_RS07950	COG1510	regulation of RNA biosynthetic process
E3S78_RS07980	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E3S78_RS08010	COG0531	amino acid
E3S78_RS08020	COG3527	Alpha-acetolactate decarboxylase
E3S78_RS08075	COG0167	dihydroorotate dehydrogenase activity
E3S78_RS08215	COG0436	Aminotransferase
E3S78_RS08260	COG2409	Drug exporters of the RND superfamily
E3S78_RS08285	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E3S78_RS08290	COG3425	synthase
E3S78_RS08300	COG3942	CHAP domain
E3S78_RS08310	COG0583	DNA-binding transcription factor activity
E3S78_RS08325	COG0028	Belongs to the TPP enzyme family
E3S78_RS08345	COG0657	acetylesterase activity
E3S78_RS08350	COG0697	spore germination
E3S78_RS08365	COG1760	l-serine dehydratase
E3S78_RS08370	COG1760	l-serine dehydratase
E3S78_RS08390	COG3764	Sortase (surface protein transpeptidase)
E3S78_RS08395	COG0561	phosphatase activity
E3S78_RS08415	COG2514	catechol 2,3-dioxygenase activity
E3S78_RS08425	COG1846	Transcriptional regulator
E3S78_RS08430	COG0346	lactoylglutathione lyase activity
E3S78_RS08435	COG0400	carboxylic ester hydrolase activity
E3S78_RS08455	COG1131	(ABC) transporter
E3S78_RS08460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E3S78_RS08470	COG1279	arginine transmembrane transporter activity
E3S78_RS08475	COG0586	Pfam SNARE associated Golgi protein
E3S78_RS08480	COG2271	Major facilitator Superfamily
E3S78_RS08490	COG4876	unkown
E3S78_RS08495	COG2357	RelA SpoT domain protein
E3S78_RS08500	COG0789	Transcriptional regulator
E3S78_RS08505	COG1802	Transcriptional regulator
E3S78_RS08510	COG1070	Carbohydrate kinase
E3S78_RS08555	COG0494	nUDIX hydrolase
E3S78_RS08630	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E3S78_RS08635	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
E3S78_RS08640	COG1028	Short-chain dehydrogenase reductase Sdr
E3S78_RS08645	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E3S78_RS08665	COG0747	negative chemotaxis
E3S78_RS08670	COG0601	transmembrane transport
E3S78_RS08675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3S78_RS08685	COG1124	(ABC) transporter
E3S78_RS08700	COG0069	glutamate synthase activity
E3S78_RS08705	COG4808	Protein conserved in bacteria
E3S78_RS08710	COG1363	Peptidase, m42
E3S78_RS08715	COG4619	ABC transporter
E3S78_RS08720	COG0390	transport system, permease component
E3S78_RS08725	COG2814	Major facilitator Superfamily
E3S78_RS08730	COG2272	Belongs to the type-B carboxylesterase lipase family
E3S78_RS08735	COG0531	amino acid
E3S78_RS08740	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
E3S78_RS08760	COG1174	glycine betaine transport
E3S78_RS08770	COG1174	glycine betaine transport
E3S78_RS08780	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E3S78_RS08795	COG0531	amino acid
E3S78_RS08805	COG1113	amino acid transport
E3S78_RS08825	COG2814	Major facilitator Superfamily
E3S78_RS08835	COG1929	Belongs to the glycerate kinase type-1 family
E3S78_RS08855	COG1132	(ABC) transporter
E3S78_RS08865	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E3S78_RS08870	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E3S78_RS08880	COG0156	8-amino-7-oxononanoate synthase activity
E3S78_RS08920	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E3S78_RS08935	COG2814	Major facilitator Superfamily
E3S78_RS08940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3S78_RS08945	COG0765	amino acid transport
E3S78_RS08950	COG1126	abc transporter atp-binding protein
E3S78_RS08985	COG3443	Belongs to the bacterial solute-binding protein 9 family
E3S78_RS08985	COG0803	Belongs to the bacterial solute-binding protein 9 family
E3S78_RS09000	COG2116	formate transmembrane transporter activity
E3S78_RS09005	COG0454	-acetyltransferase
E3S78_RS09015	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E3S78_RS09020	COG2146	nitrite reductase [NAD(P)H] activity
E3S78_RS09030	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
E3S78_RS09035	COG1140	nitrate reductase beta subunit
E3S78_RS09045	COG2181	nitrate reductase activity
E3S78_RS09110	COG3871	stress protein (general stress protein 26)
E3S78_RS09125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3S78_RS09125	COG1263	PTS System
E3S78_RS09140	COG1511	domain protein
E3S78_RS09165	COG0604	alcohol dehydrogenase
E3S78_RS09185	COG1620	l-lactate permease
E3S78_RS09200	COG1131	(ABC) transporter
E3S78_RS09260	COG2814	Major facilitator Superfamily
E3S78_RS09275	COG1566	PFAM secretion protein HlyD family protein
E3S78_RS09280	COG2814	Major facilitator Superfamily
E3S78_RS09290	COG0657	acetylesterase activity
E3S78_RS09305	COG0598	Magnesium transport protein CorA
E3S78_RS09315	COG0786	glutamate:sodium symporter activity
E3S78_RS09330	COG4152	abc transporter atp-binding protein
E3S78_RS09335	COG1668	transmembrane transport
E3S78_RS09355	COG2258	MOSC domain
E3S78_RS09380	COG0583	DNA-binding transcription factor activity
E3S78_RS09400	COG1028	Short-chain dehydrogenase reductase Sdr
E3S78_RS09420	COG1737	Transcriptional regulator
E3S78_RS09425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3S78_RS09425	COG1263	PTS System
E3S78_RS09440	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E3S78_RS09460	COG1113	amino acid transport
E3S78_RS09540	COG1757	Na H antiporter
E3S78_RS09610	COG4413	Urea transporter
E3S78_RS09615	COG1960	acyl-CoA dehydrogenase activity
E3S78_RS09630	COG1268	BioY protein
E3S78_RS09645	COG0725	ABC transporter, periplasmic molybdate-binding protein
E3S78_RS09650	COG4149	molybdate abc transporter
E3S78_RS09655	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
E3S78_RS09660	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E3S78_RS09680	COG1763	Mo-molybdopterin cofactor biosynthetic process
E3S78_RS09740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E3S78_RS09785	COG2252	PERMEase
E3S78_RS09900	COG0201	protein transport
E3S78_RS09995	COG0028	Belongs to the TPP enzyme family
E3S78_RS10000	COG3527	Alpha-acetolactate decarboxylase
E3S78_RS10020	COG5492	domain, Protein
E3S78_RS10030	COG0789	Transcriptional regulator
E3S78_RS10035	COG0656	L-ascorbic acid biosynthetic process
E3S78_RS10110	COG2130	NADP-dependent
E3S78_RS10120	COG2826	transposase and inactivated derivatives, IS30 family
E3S78_RS10125	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E3S78_RS10150	COG2814	Major facilitator Superfamily
E3S78_RS10155	COG4264	IucA IucC family
E3S78_RS10160	COG3457	Alanine racemase
E3S78_RS10170	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
E3S78_RS10175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3S78_RS10180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3S78_RS10195	COG1988	membrane-bound metal-dependent
E3S78_RS10205	COG1272	protein, Hemolysin III
E3S78_RS10225	COG0489	protein tyrosine kinase activity
E3S78_RS10285	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
E3S78_RS10315	COG3711	transcriptional antiterminator
E3S78_RS10330	COG1119	ATPase activity
E3S78_RS10335	COG0561	phosphatase activity
E3S78_RS10365	COG0640	Transcriptional regulator
E3S78_RS10370	COG0702	epimerase
E3S78_RS10375	COG1482	cell wall glycoprotein biosynthetic process
E3S78_RS10395	COG0783	Belongs to the Dps family
E3S78_RS10400	COG0813	purine-nucleoside phosphorylase activity
E3S78_RS10450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E3S78_RS10490	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E3S78_RS10510	COG2890	protein-(glutamine-N5) methyltransferase activity
E3S78_RS10515	COG0009	L-threonylcarbamoyladenylate synthase
E3S78_RS10540	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E3S78_RS10615	COG0629	single-stranded DNA binding
E3S78_RS10660	COG1418	mRNA catabolic process
E3S78_RS10670	COG1937	Protein conserved in bacteria
E3S78_RS10690	COG0772	Belongs to the SEDS family
E3S78_RS10700	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E3S78_RS10710	COG0745	RESPONSE REGULATOR receiver
E3S78_RS10715	COG2205	protein histidine kinase activity
E3S78_RS10745	COG3428	Bacterial PH domain
E3S78_RS10775	COG2208	phosphoserine phosphatase activity
E3S78_RS10780	COG1366	Belongs to the anti-sigma-factor antagonist family
E3S78_RS10790	COG1191	sigma factor activity
E3S78_RS10795	COG2183	response to ionizing radiation
E3S78_RS10870	COG0028	Belongs to the TPP enzyme family
E3S78_RS10885	COG0802	atpase or kinase
E3S78_RS10890	COG1214	PFAM Peptidase M22, glycoprotease
E3S78_RS10895	COG0456	acetyltransferase
E3S78_RS10905	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E3S78_RS10915	COG0488	(ABC) transporter
E3S78_RS10925	COG2391	methyltransferase activity
E3S78_RS10930	COG0425	Belongs to the sulfur carrier protein TusA family
E3S78_RS10935	COG0004	ammonium transporteR
E3S78_RS10940	COG1609	Transcriptional regulator
E3S78_RS10945	COG1621	beta-fructofuranosidase activity
E3S78_RS10950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3S78_RS11025	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E3S78_RS11075	COG1725	Transcriptional regulator
E3S78_RS11090	COG1131	(ABC) transporter
E3S78_RS11140	COG1012	belongs to the aldehyde dehydrogenase family
E3S78_RS11155	COG1335	isochorismatase
E3S78_RS11175	COG0077	Prephenate dehydratase
E3S78_RS11185	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E3S78_RS11220	COG4496	protein, YerC YecD
E3S78_RS11240	COG4851	CamS sex pheromone cAM373 precursor
E3S78_RS11355	COG1295	ribonuclease BN
E3S78_RS11375	COG2309	aminopeptidase activity
E3S78_RS11380	COG1607	acyl-coa hydrolase
E3S78_RS11385	COG0535	radical SAM domain protein
E3S78_RS11390	COG4974	Belongs to the 'phage' integrase family
E3S78_RS11485	COG1484	DNA-dependent DNA replication
E3S78_RS11685	COG1388	LysM domain
E3S78_RS11685	COG5632	N-Acetylmuramoyl-L-alanine amidase
E3S78_RS11720	COG1388	LysM domain
E3S78_RS11720	COG1134	teichoic acid transport
E3S78_RS11730	COG1988	membrane-bound metal-dependent
E3S78_RS11735	COG1194	a g-specific adenine glycosylase
E3S78_RS11750	COG4129	membrane
E3S78_RS11760	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E3S78_RS11765	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E3S78_RS11930	COG0765	amino acid transport
E3S78_RS11935	COG1126	abc transporter atp-binding protein
E3S78_RS11940	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E3S78_RS11970	COG0564	pseudouridine synthase activity
E3S78_RS11975	COG4585	Histidine kinase
E3S78_RS11975	COG2203	Gaf domain
E3S78_RS11980	COG2197	response regulator
E3S78_RS12000	COG0420	3'-5' exonuclease activity
E3S78_RS12030	COG0537	adenosine 5'-monophosphoramidase activity
E3S78_RS12035	COG1131	(ABC) transporter
E3S78_RS12245	COG5492	domain, Protein
E3S78_RS12335	COG2816	NAD+ diphosphatase activity
E3S78_RS12340	COG1506	peptidase
E3S78_RS12360	COG0656	L-ascorbic acid biosynthetic process
E3S78_RS12370	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E3S78_RS12380	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E3S78_RS12415	COG3266	domain, Protein
E3S78_RS12415	COG5632	N-Acetylmuramoyl-L-alanine amidase
E3S78_RS12415	COG4193	domain, Protein
E3S78_RS12435	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E3S78_RS12435	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E3S78_RS12465	COG2267	carboxylic ester hydrolase activity
E3S78_RS12470	COG1846	Transcriptional regulator
E3S78_RS12475	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
E3S78_RS12480	COG1242	4 iron, 4 sulfur cluster binding
E3S78_RS12485	COG2814	Major facilitator Superfamily
E3S78_RS12505	COG2081	HI0933 family
E3S78_RS12510	COG2244	polysaccharide biosynthetic process
E3S78_RS12515	COG1187	pseudouridine synthase activity
E3S78_RS12535	COG0510	thiamine kinase activity
E3S78_RS12580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E3S78_RS12590	COG1363	Peptidase, m42
E3S78_RS12595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E3S78_RS12605	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E3S78_RS12610	COG1674	ftsk spoiiie
E3S78_RS12635	COG1605	Chorismate mutase
E3S78_RS12635	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
E3S78_RS12655	COG0454	-acetyltransferase
E3S78_RS12660	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E3S78_RS12690	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E3S78_RS12695	COG0204	Acyl-transferase
E3S78_RS12700	COG1263	PTS System
E3S78_RS12700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3S78_RS12715	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E3S78_RS12720	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E3S78_RS12725	COG1764	response to oxidative stress
E3S78_RS12730	COG0584	glycerophosphoryl diester phosphodiesterase
E3S78_RS12745	COG1956	GAF domain-containing protein
E3S78_RS12760	COG1104	cysteine desulfurase activity
E3S78_RS12770	COG0730	response to heat
E3S78_RS12780	COG0827	DNA restriction-modification system
E3S78_RS12820	COG4109	DRTGG domain
E3S78_RS12825	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E3S78_RS12835	COG0281	malic enzyme
E3S78_RS12860	COG1113	amino acid transport
E3S78_RS12865	COG0372	Belongs to the citrate synthase family
E3S78_RS12875	COG0745	RESPONSE REGULATOR receiver
E3S78_RS12880	COG5002	protein histidine kinase activity
E3S78_RS12890	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E3S78_RS12890	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E3S78_RS12895	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E3S78_RS12920	COG1484	DNA-dependent DNA replication
E3S78_RS12935	COG0833	amino acid
E3S78_RS12955	COG4112	unkown
E3S78_RS12990	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E3S78_RS13005	COG0113	porphobilinogen synthase activity
E3S78_RS13025	COG2818	Glycosylase
E3S78_RS13035	COG0285	dihydrofolate synthase activity
E3S78_RS13040	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
E3S78_RS13085	COG2868	ribosomal protein
E3S78_RS13125	COG1862	Preprotein translocase
E3S78_RS13130	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E3S78_RS13130	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E3S78_RS13135	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E3S78_RS13135	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E3S78_RS13180	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E3S78_RS13185	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E3S78_RS13190	COG1959	2 iron, 2 sulfur cluster binding
E3S78_RS13205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E3S78_RS13210	COG1104	cysteine desulfurase activity
E3S78_RS13225	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E3S78_RS13275	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E3S78_RS13280	COG1984	allophanate hydrolase subunit 2
E3S78_RS13285	COG0511	ligase activity, forming carbon-carbon bonds
E3S78_RS13290	COG0439	Biotin carboxylase
E3S78_RS13300	COG1914	H( )-stimulated, divalent metal cation uptake system
E3S78_RS13325	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
E3S78_RS13330	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
E3S78_RS13340	COG1534	Rna-binding protein
E3S78_RS13350	COG1713	HD superfamily hydrolase involved in NAD metabolism
E3S78_RS13355	COG0799	negative regulation of ribosome biogenesis
E3S78_RS13360	COG2226	methyltransferase
E3S78_RS13370	COG2131	deaminase
E3S78_RS13375	COG0658	competence protein
E3S78_RS13375	COG2333	competence protein COMEC
E3S78_RS13380	COG1466	dna polymerase III delta subunit
E3S78_RS13395	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E3S78_RS13425	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E3S78_RS13430	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E3S78_RS13440	COG1030	water channel activity
E3S78_RS13455	COG1702	phosphate starvation-inducible protein PhoH
E3S78_RS13470	COG0295	cytidine deaminase activity
E3S78_RS13490	COG0517	IMP dehydrogenase activity
E3S78_RS13505	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E3S78_RS13510	COG2384	SAM-dependent methyltransferase
E3S78_RS13520	COG0513	Belongs to the DEAD box helicase family
E3S78_RS13530	COG1121	(ABC) transporter
E3S78_RS13535	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E3S78_RS13540	COG0735	belongs to the Fur family
E3S78_RS13560	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E3S78_RS13570	COG4483	Protein conserved in bacteria
E3S78_RS13575	COG1940	carbohydrate kinase activity
E3S78_RS13580	COG0011	TIGRFAM Protein of
E3S78_RS13585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E3S78_RS13590	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E3S78_RS13595	COG1459	type II secretion system
E3S78_RS13600	COG4537	Required for transformation and DNA binding
E3S78_RS13645	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E3S78_RS13650	COG0095	Lipoate-protein ligase
E3S78_RS13665	COG0006	proline dipeptidase activity
E3S78_RS13675	COG0511	ligase activity, forming carbon-carbon bonds
E3S78_RS13680	COG0439	Biotin carboxylase
E3S78_RS13685	COG1302	Protein conserved in bacteria
E3S78_RS13715	COG0497	DNA recombination
E3S78_RS13720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3S78_RS13725	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E3S78_RS13730	COG0022	dehydrogenase e1 component
E3S78_RS13735	COG0508	dehydrogenase complex catalyzes the overall conversion of
E3S78_RS13745	COG4129	membrane
E3S78_RS13755	COG2195	Cleaves the N-terminal amino acid of tripeptides
E3S78_RS13795	COG1609	Transcriptional regulator
E3S78_RS13800	COG0366	Alpha amylase catalytic
E3S78_RS13810	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E3S78_RS13825	COG4221	oxidoreductase activity
E3S78_RS13835	COG0667	Aldo Keto reductase
E3S78_RS13840	COG0494	nUDIX hydrolase
E3S78_RS13845	COG0735	belongs to the Fur family
E3S78_RS13870	COG1187	pseudouridine synthase activity
E3S78_RS13875	COG0745	RESPONSE REGULATOR receiver
E3S78_RS13895	COG0582	viral genome integration into host DNA