locus-tag	class	description
LG33_RS00015	COG2501	S4 domain
LG33_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LG33_RS00065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LG33_RS00075	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
LG33_RS00085	COG0305	Participates in initiation and elongation during chromosome replication
LG33_RS00120	COG4863	YycH protein
LG33_RS00130	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LG33_RS00135	COG0737	Belongs to the 5'-nucleotidase family
LG33_RS00165	COG0584	glycerophosphoryl diester phosphodiesterase
LG33_RS00170	COG2030	dehydratase
LG33_RS00290	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LG33_RS00340	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LG33_RS00345	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LG33_RS00355	COG2235	arginine
LG33_RS00405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LG33_RS00410	COG4172	Belongs to the ABC transporter superfamily
LG33_RS00415	COG1124	(ABC) transporter
LG33_RS00425	COG1388	LysM domain
LG33_RS00455	COG0730	response to heat
LG33_RS00460	COG1937	Protein conserved in bacteria
LG33_RS00465	COG2210	Belongs to the sulfur carrier protein TusA family
LG33_RS00470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LG33_RS00530	COG0583	DNA-binding transcription factor activity
LG33_RS00550	COG0823	Involved in the tonB-independent uptake of proteins
LG33_RS00580	COG1473	amidohydrolase
LG33_RS00590	COG1283	sodium-dependent phosphate transmembrane transporter activity
LG33_RS00595	COG4716	Myosin-crossreactive antigen
LG33_RS00600	COG0697	spore germination
LG33_RS00615	COG1620	l-lactate permease
LG33_RS00635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LG33_RS00640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LG33_RS00645	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LG33_RS00655	COG2423	ornithine cyclodeaminase activity
LG33_RS00660	COG4264	IucA IucC family
LG33_RS00665	COG2814	Major facilitator Superfamily
LG33_RS00670	COG4264	IucA IucC family
LG33_RS00675	COG4264	IucA IucC family
LG33_RS00685	COG0019	diaminopimelate decarboxylase activity
LG33_RS00690	COG1475	DNA binding
LG33_RS00720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LG33_RS00725	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LG33_RS00730	COG0438	transferase activity, transferring glycosyl groups
LG33_RS00765	COG0813	purine-nucleoside phosphorylase activity
LG33_RS00770	COG2814	Major facilitator Superfamily
LG33_RS00790	COG3639	organic phosphonate transmembrane transporter activity
LG33_RS00810	COG0737	Belongs to the 5'-nucleotidase family
LG33_RS00850	COG1012	belongs to the aldehyde dehydrogenase family
LG33_RS00850	COG1454	alcohol dehydrogenase
LG33_RS00875	COG1086	Polysaccharide biosynthesis protein
LG33_RS00885	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LG33_RS00915	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LG33_RS00925	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LG33_RS00930	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LG33_RS00940	COG2832	Protein of unknown function (DUF454)
LG33_RS00975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LG33_RS00980	COG1960	acyl-CoA dehydrogenase activity
LG33_RS00985	COG5609	conserved protein (DUF2294)
LG33_RS01035	COG1114	Component of the transport system for branched-chain amino acids
LG33_RS01040	COG1335	isochorismatase
LG33_RS01045	COG3961	Belongs to the TPP enzyme family
LG33_RS01075	COG1737	Transcriptional regulator
LG33_RS01110	COG0601	transmembrane transport
LG33_RS01115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LG33_RS01125	COG0405	Gamma-glutamyltransferase
LG33_RS01145	COG3842	ATPase activity
LG33_RS01155	COG1175	transmembrane transport
LG33_RS01160	COG3833	ABC-type maltose transport systems, permease component
LG33_RS01165	COG0673	inositol 2-dehydrogenase activity
LG33_RS01170	COG0673	inositol 2-dehydrogenase activity
LG33_RS01180	COG1755	Isoprenylcysteine carboxyl methyltransferase
LG33_RS01240	COG0183	Belongs to the thiolase family
LG33_RS01250	COG1960	acyl-CoA dehydrogenase activity
LG33_RS01255	COG0318	PFAM AMP-dependent synthetase and ligase
LG33_RS01270	COG0747	negative chemotaxis
LG33_RS01275	COG3189	MarR family transcriptional regulator
LG33_RS01305	COG2190	(PTS) system
LG33_RS01305	COG1263	PTS System
LG33_RS01305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LG33_RS01310	COG1957	nucleoside hydrolase
LG33_RS01330	COG3414	Phosphotransferase system galactitol-specific IIB component
LG33_RS01335	COG3775	system Galactitol-specific IIC component
LG33_RS01340	COG1063	alcohol dehydrogenase
LG33_RS01350	COG1063	alcohol dehydrogenase
LG33_RS01360	COG1063	alcohol dehydrogenase
LG33_RS01365	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LG33_RS01370	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LG33_RS01380	COG1063	alcohol dehydrogenase
LG33_RS01385	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LG33_RS01420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LG33_RS01430	COG2190	(PTS) system
LG33_RS01430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LG33_RS01430	COG1263	PTS System
LG33_RS01435	COG2723	6-phospho-beta-galactosidase activity
LG33_RS01445	COG2226	methyltransferase
LG33_RS01505	COG1131	(ABC) transporter
LG33_RS01535	COG1388	LysM domain
LG33_RS01535	COG3942	CHAP domain
LG33_RS01680	COG1114	Component of the transport system for branched-chain amino acids
LG33_RS01690	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
LG33_RS01700	COG0577	efflux transmembrane transporter activity
LG33_RS01730	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LG33_RS01735	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LG33_RS01760	COG3314	Sporulation integral membrane protein YlbJ
LG33_RS01785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LG33_RS01815	COG3037	sugar-specific permease SgaT UlaA
LG33_RS01825	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LG33_RS01830	COG3711	transcriptional antiterminator
LG33_RS01855	COG2271	Major facilitator Superfamily
LG33_RS01860	COG0346	lactoylglutathione lyase activity
LG33_RS01865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LG33_RS01870	COG0431	NADPH-dependent FMN reductase
LG33_RS01885	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LG33_RS01900	COG0672	)-iron permease
LG33_RS01905	COG0805	protein transport
LG33_RS01910	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LG33_RS01920	COG1476	TRANSCRIPTIONal
LG33_RS01930	COG1131	(ABC) transporter
LG33_RS01960	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LG33_RS01960	COG0646	methionine synthase
LG33_RS01965	COG0626	cystathionine gamma-synthase activity
LG33_RS01970	COG0626	cystathionine gamma-synthase activity
LG33_RS01980	COG1475	DNA binding
LG33_RS01985	COG0668	transmembrane transport
LG33_RS01990	COG4481	Protein conserved in bacteria
LG33_RS01995	COG0012	GTP binding
LG33_RS02090	COG3634	alkyl hydroperoxide reductase activity
LG33_RS02105	COG1823	symporter activity
LG33_RS02140	COG2233	PERMEase
LG33_RS02180	COG3759	membrane
LG33_RS02350	COG0523	cobalamin synthesis protein
LG33_RS02365	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LG33_RS02375	COG5609	conserved protein (DUF2294)
LG33_RS02390	COG1647	Serine aminopeptidase, S33
LG33_RS02400	COG0733	neurotransmitter:sodium symporter activity
LG33_RS02405	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LG33_RS02410	COG0626	cystathionine gamma-synthase activity
LG33_RS02420	COG2011	ABC-type metal ion transport system permease component
LG33_RS02425	COG1464	Belongs to the NlpA lipoprotein family
LG33_RS02460	COG0583	DNA-binding transcription factor activity
LG33_RS02465	COG0070	glutamate synthase
LG33_RS02465	COG0069	glutamate synthase activity
LG33_RS02465	COG0067	glutamate synthase
LG33_RS02470	COG0493	'glutamate synthase
LG33_RS02480	COG1263	PTS System
LG33_RS02480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LG33_RS02485	COG0366	Alpha amylase catalytic
LG33_RS02490	COG2188	Transcriptional regulator
LG33_RS02510	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LG33_RS02550	COG1982	Orn Lys Arg decarboxylase major
LG33_RS02560	COG3870	Protein conserved in bacteria
LG33_RS02565	COG0470	DNA polymerase III
LG33_RS02570	COG1774	PSP1 C-terminal conserved region
LG33_RS02580	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LG33_RS02590	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LG33_RS02600	COG0084	hydrolase, TatD family'
LG33_RS02605	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
LG33_RS02615	COG4466	Protein conserved in bacteria
LG33_RS02625	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LG33_RS02630	COG0251	oxidation-reduction process
LG33_RS02675	COG2244	polysaccharide biosynthetic process
LG33_RS02680	COG3956	TIGRFAM MazG family protein
LG33_RS02685	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LG33_RS02695	COG1098	S1 RNA binding domain
LG33_RS02710	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LG33_RS02735	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LG33_RS02815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LG33_RS02830	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LG33_RS02840	COG3880	PFAM UvrB UvrC protein
LG33_RS02855	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LG33_RS02860	COG4956	integral membrane protein (PIN domain superfamily)
LG33_RS02885	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
LG33_RS02940	COG2813	Specifically methylates the guanine in position
LG33_RS02980	COG1473	amidohydrolase
LG33_RS03015	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LG33_RS03020	COG1428	Deoxynucleoside kinase
LG33_RS03025	COG1428	Deoxynucleoside kinase
LG33_RS03035	COG0561	phosphatase activity
LG33_RS03080	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LG33_RS03195	COG0095	Lipoate-protein ligase
LG33_RS03200	COG0083	homoserine kinase activity
LG33_RS03220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LG33_RS03315	COG0667	Aldo Keto reductase
LG33_RS03320	COG0655	NAD(P)H dehydrogenase (quinone) activity
LG33_RS03330	COG1078	dGTPase activity
LG33_RS03375	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LG33_RS03380	COG4139	cobalamin transport
LG33_RS03450	COG4974	Belongs to the 'phage' integrase family
LG33_RS03495	COG0803	Belongs to the bacterial solute-binding protein 9 family
LG33_RS03500	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LG33_RS03505	COG1121	(ABC) transporter
LG33_RS03510	COG1321	iron dependent repressor
LG33_RS03520	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
LG33_RS03530	COG1682	transport, permease protein
LG33_RS03535	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LG33_RS03540	COG1216	Glycosyl transferase, family 2
LG33_RS03545	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LG33_RS03550	COG1686	Belongs to the peptidase S11 family
LG33_RS03555	COG1132	(ABC) transporter
LG33_RS03560	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LG33_RS03570	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LG33_RS03575	COG1120	ATPase activity
LG33_RS03580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LG33_RS03585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LG33_RS03590	COG2376	Dihydroxyacetone kinase
LG33_RS03600	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
LG33_RS03610	COG3949	Membrane
LG33_RS03635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LG33_RS03650	COG1136	(ABC) transporter
LG33_RS03655	COG0577	efflux transmembrane transporter activity
LG33_RS03660	COG1392	Phosphate transport regulator
LG33_RS03665	COG0306	phosphate transporter
LG33_RS03670	COG1388	LysM domain
LG33_RS03670	COG3942	CHAP domain
LG33_RS03710	COG0583	DNA-binding transcription factor activity
LG33_RS03725	COG2814	Major facilitator Superfamily
LG33_RS03730	COG2839	Protein conserved in bacteria
LG33_RS03760	COG1611	Belongs to the LOG family
LG33_RS03780	COG4988	ABC transporter
LG33_RS03785	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LG33_RS03795	COG0523	cobalamin synthesis protein
LG33_RS03800	COG4989	oxidoreductase activity
LG33_RS03810	COG0471	metal ion transport
LG33_RS03815	COG0415	Belongs to the DNA photolyase family
LG33_RS03845	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LG33_RS03850	COG1349	DNA-binding transcription factor activity
LG33_RS03855	COG1105	Belongs to the carbohydrate kinase PfkB family
LG33_RS03860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LG33_RS03860	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LG33_RS03860	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LG33_RS03865	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LG33_RS03870	COG1253	flavin adenine dinucleotide binding
LG33_RS03875	COG0656	L-ascorbic acid biosynthetic process
LG33_RS03880	COG0463	Glycosyl transferase, family 2
LG33_RS03915	COG0720	synthase
LG33_RS03925	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LG33_RS03925	COG0512	Glutamine amidotransferase of anthranilate synthase
LG33_RS03930	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LG33_RS03960	COG0488	(ABC) transporter
LG33_RS03965	COG0514	ATP-dependent DNA helicase (RecQ)
LG33_RS03970	COG1125	glycine betaine transport
LG33_RS03970	COG0517	IMP dehydrogenase activity
LG33_RS03975	COG1174	glycine betaine transport
LG33_RS04010	COG3104	oligopeptide transport
LG33_RS04040	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LG33_RS04045	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LG33_RS04060	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LG33_RS04065	COG4605	iron ion homeostasis
LG33_RS04070	COG4604	ABC transporter, ATP-binding protein
LG33_RS04075	COG4607	ABC-type enterochelin transport system periplasmic component
LG33_RS04135	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LG33_RS04140	COG1739	Uncharacterized protein family UPF0029
LG33_RS04150	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
LG33_RS04155	COG1040	competence protein
LG33_RS04185	COG3942	CHAP domain
LG33_RS04185	COG1388	LysM domain
LG33_RS04255	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LG33_RS04325	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LG33_RS04330	COG1647	Serine aminopeptidase, S33
LG33_RS04335	COG0557	exoribonuclease II activity
LG33_RS04410	COG1278	Cold shock
LG33_RS04450	COG0406	alpha-ribazole phosphatase activity
LG33_RS04455	COG1279	arginine transmembrane transporter activity
LG33_RS04480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LG33_RS04485	COG1393	Belongs to the ArsC family
LG33_RS04500	COG3878	Protein conserved in bacteria
LG33_RS04515	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
LG33_RS04530	COG2011	ABC-type metal ion transport system permease component
LG33_RS04535	COG1464	Belongs to the NlpA lipoprotein family
LG33_RS04540	COG0582	viral genome integration into host DNA
LG33_RS04655	COG0396	ATPase activity
LG33_RS04660	COG0719	Fe-S assembly protein
LG33_RS04670	COG0822	iron-sulfur transferase activity
LG33_RS04695	COG1253	flavin adenine dinucleotide binding
LG33_RS04710	COG1801	Protein of unknown function DUF72
LG33_RS04715	COG0730	response to heat
LG33_RS04730	COG4470	Protein conserved in bacteria
LG33_RS04740	COG2445	Protein of unknown function DUF86
LG33_RS04770	COG1696	Membrane protein involved in D-alanine export
LG33_RS04780	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
LG33_RS04785	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LG33_RS04790	COG4837	Protein of unknown function (DUF1462)
LG33_RS04795	COG1252	NADH dehydrogenase
LG33_RS04805	COG0316	Belongs to the HesB IscA family
LG33_RS04815	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LG33_RS04820	COG2056	Na+-H+ antiporter family
LG33_RS04825	COG2050	protein possibly involved in aromatic compounds catabolism
LG33_RS04880	COG1098	S1 RNA binding domain
LG33_RS04885	COG1902	pentaerythritol trinitrate reductase activity
LG33_RS04910	COG0584	glycerophosphoryl diester phosphodiesterase
LG33_RS04930	COG0398	Pfam SNARE associated Golgi protein
LG33_RS04970	COG0561	phosphatase activity
LG33_RS04995	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LG33_RS05010	COG1881	PFAM PEBP family protein
LG33_RS05040	COG0601	transmembrane transport
LG33_RS05045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LG33_RS05050	COG0444	Belongs to the ABC transporter superfamily
LG33_RS05055	COG4608	Belongs to the ABC transporter superfamily
LG33_RS05060	COG4166	transmembrane transport
LG33_RS05065	COG0747	negative chemotaxis
LG33_RS05070	COG0444	Belongs to the ABC transporter superfamily
LG33_RS05075	COG4608	Belongs to the ABC transporter superfamily
LG33_RS05080	COG0601	transmembrane transport
LG33_RS05085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LG33_RS05115	COG1164	Oligoendopeptidase f
LG33_RS05125	COG2346	COG2346, Truncated hemoglobins
LG33_RS05140	COG2357	RelA SpoT domain protein
LG33_RS05150	COG0564	pseudouridine synthase activity
LG33_RS05155	COG2239	Acts as a magnesium transporter
LG33_RS05160	COG0569	domain protein
LG33_RS05160	COG0475	glutathione-regulated potassium exporter activity
LG33_RS05170	COG0628	permease
LG33_RS05175	COG1115	amino acid carrier protein
LG33_RS05215	COG0861	Integral membrane protein TerC family
LG33_RS05225	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LG33_RS05230	COG0737	Belongs to the 5'-nucleotidase family
LG33_RS05245	COG4903	ComK protein
LG33_RS05260	COG4873	Protein conserved in bacteria
LG33_RS05320	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
LG33_RS05330	COG2314	TM2 domain
LG33_RS05335	COG0456	acetyltransferase
LG33_RS05340	COG1575	Belongs to the MenA family. Type 1 subfamily
LG33_RS05350	COG1169	isochorismate synthase
LG33_RS05360	COG2267	carboxylic ester hydrolase activity
LG33_RS05385	COG0436	Aminotransferase
LG33_RS05390	COG3594	Acyltransferase
LG33_RS05420	COG1316	TRANSCRIPTIONal
LG33_RS05425	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LG33_RS05470	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LG33_RS05485	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LG33_RS05525	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
LG33_RS05530	COG4172	Belongs to the ABC transporter superfamily
LG33_RS05535	COG4721	ABC-type cobalt transport system, permease component
LG33_RS05560	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LG33_RS05585	COG1271	oxidase subunit
LG33_RS05590	COG1294	oxidase, subunit
LG33_RS05595	COG0569	domain protein
LG33_RS05665	COG1176	ABC-type spermidine putrescine transport system, permease component I
LG33_RS05670	COG1177	transmembrane transport
LG33_RS05675	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LG33_RS05700	COG0483	inositol monophosphate 1-phosphatase activity
LG33_RS05710	COG1217	gtp-binding protein TYPA
LG33_RS05720	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LG33_RS05730	COG0772	Belongs to the SEDS family
LG33_RS05765	COG3679	Belongs to the UPF0342 family
LG33_RS05785	COG0742	ribosomal rna small subunit methyltransferase
LG33_RS05845	COG4509	Sortase family
LG33_RS05860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LG33_RS05895	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LG33_RS05895	COG1796	DNA polymerase
LG33_RS05920	COG2009	succinate dehydrogenase
LG33_RS05925	COG1053	succinate dehydrogenase
LG33_RS05930	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LG33_RS06050	COG1288	antiporter activity
LG33_RS06085	COG1011	Hydrolase
LG33_RS06110	COG4839	cell division protein FtsL
LG33_RS06115	COG0768	penicillin binding
LG33_RS06130	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LG33_RS06135	COG0849	cell division
LG33_RS06150	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LG33_RS06160	COG0762	integral membrane protein
LG33_RS06165	COG2302	S4 RNA-binding domain
LG33_RS06170	COG3599	regulation of cell shape
LG33_RS06180	COG2514	catechol 2,3-dioxygenase activity
LG33_RS06195	COG0564	pseudouridine synthase activity
LG33_RS06205	COG2233	PERMEase
LG33_RS06250	COG1293	RNA-binding protein homologous to eukaryotic snRNP
LG33_RS06265	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LG33_RS06270	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LG33_RS06280	COG2314	TM2 domain
LG33_RS06295	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LG33_RS06295	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LG33_RS06305	COG0631	protein serine/threonine phosphatase activity
LG33_RS06320	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LG33_RS06335	COG1302	Protein conserved in bacteria
LG33_RS06345	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LG33_RS06385	COG1196	nuclear chromosome segregation
LG33_RS06390	COG0552	protein localization to endoplasmic reticulum
LG33_RS06400	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LG33_RS06460	COG0758	DNA mediated transformation
LG33_RS06560	COG0195	Participates in both transcription termination and antitermination
LG33_RS06565	COG2740	Nucleic-acid-binding protein implicated in transcription termination
LG33_RS06590	COG0196	riboflavin kinase activity
LG33_RS06620	COG2188	Transcriptional regulator
LG33_RS06625	COG0612	Peptidase, M16
LG33_RS06630	COG0612	Peptidase, M16
LG33_RS06635	COG0300	oxidoreductase activity
LG33_RS06655	COG1058	Belongs to the CinA family
LG33_RS06655	COG1546	Belongs to the CinA family
LG33_RS06675	COG1692	metallophosphoesterase
LG33_RS06680	COG0674	pyruvate-flavodoxin oxidoreductase activity
LG33_RS06680	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LG33_RS06685	COG1013	pyruvate-flavodoxin oxidoreductase activity
LG33_RS06720	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
LG33_RS06725	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LG33_RS06750	COG1923	regulation of RNA biosynthetic process
LG33_RS06760	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LG33_RS06765	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
LG33_RS06770	COG0789	Transcriptional regulator
LG33_RS06890	COG1131	(ABC) transporter
LG33_RS06905	COG2197	response regulator
LG33_RS06915	COG1525	nuclease
LG33_RS06930	COG0527	aspartate kinase activity
LG33_RS06935	COG0460	homoserine dehydrogenase
LG33_RS06940	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LG33_RS06965	COG0833	amino acid
LG33_RS06995	COG2340	Cysteine-rich secretory protein family
LG33_RS07030	COG4846	Membrane protein involved in cytochrome C biogenesis
LG33_RS07050	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LG33_RS07060	COG0824	Thioesterase
LG33_RS07100	COG1115	amino acid carrier protein
LG33_RS07115	COG0628	permease
LG33_RS07120	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LG33_RS07120	COG0392	lysyltransferase activity
LG33_RS07140	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LG33_RS07150	COG1363	Peptidase, m42
LG33_RS07155	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LG33_RS07160	COG0512	Glutamine amidotransferase of anthranilate synthase
LG33_RS07200	COG0561	phosphatase activity
LG33_RS07245	COG0704	Plays a role in the regulation of phosphate uptake
LG33_RS07255	COG0581	inorganic phosphate transmembrane transporter activity
LG33_RS07260	COG0573	inorganic phosphate transmembrane transporter activity
LG33_RS07280	COG0488	(ABC) transporter
LG33_RS07285	COG0527	aspartate kinase activity
LG33_RS07290	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LG33_RS07370	COG4548	von Willebrand factor, type A
LG33_RS07425	COG0671	phosphoesterase, PA-phosphatase related
LG33_RS07500	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LG33_RS07530	COG0531	amino acid
LG33_RS07545	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LG33_RS07550	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
LG33_RS07565	COG0116	Belongs to the methyltransferase superfamily
LG33_RS07600	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LG33_RS07600	COG4499	WXG100 protein secretion system (Wss), protein YukC
LG33_RS07610	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LG33_RS07615	COG3935	DnaD domain protein
LG33_RS07640	COG0438	transferase activity, transferring glycosyl groups
LG33_RS07645	COG1694	Mazg nucleotide pyrophosphohydrolase
LG33_RS07650	COG2738	Putative neutral zinc metallopeptidase
LG33_RS07655	COG4347	Protein of unknown function (DUF1405)
LG33_RS07695	COG0142	geranyltranstransferase activity
LG33_RS07760	COG0492	ferredoxin-NADP+ reductase activity
LG33_RS07775	COG0514	ATP-dependent DNA helicase (RecQ)
LG33_RS07785	COG1141	Ferredoxin
LG33_RS07835	COG0860	N-Acetylmuramoyl-L-alanine amidase
LG33_RS07835	COG1388	LysM domain
LG33_RS07885	COG5280	Phage tail tape measure protein TP901
LG33_RS07885	COG3953	SLT domain
LG33_RS08145	COG0582	viral genome integration into host DNA
LG33_RS08165	COG5002	protein histidine kinase activity
LG33_RS08170	COG0745	RESPONSE REGULATOR receiver
LG33_RS08175	COG1187	pseudouridine synthase activity
LG33_RS08200	COG0735	belongs to the Fur family
LG33_RS08205	COG0494	nUDIX hydrolase
LG33_RS08210	COG0667	Aldo Keto reductase
LG33_RS08220	COG4221	oxidoreductase activity
LG33_RS08235	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LG33_RS08245	COG0366	Alpha amylase catalytic
LG33_RS08250	COG1609	Transcriptional regulator
LG33_RS08270	COG2195	Cleaves the N-terminal amino acid of tripeptides
LG33_RS08280	COG4129	membrane
LG33_RS08290	COG0508	dehydrogenase complex catalyzes the overall conversion of
LG33_RS08295	COG0022	dehydrogenase e1 component
LG33_RS08300	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LG33_RS08305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LG33_RS08310	COG0497	DNA recombination
LG33_RS08340	COG1302	Protein conserved in bacteria
LG33_RS08345	COG0439	Biotin carboxylase
LG33_RS08350	COG0511	ligase activity, forming carbon-carbon bonds
LG33_RS08360	COG0006	proline dipeptidase activity
LG33_RS08375	COG0095	Lipoate-protein ligase
LG33_RS08380	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LG33_RS08425	COG4537	Required for transformation and DNA binding
LG33_RS08430	COG1459	type II secretion system
LG33_RS08435	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LG33_RS08440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LG33_RS08445	COG0011	TIGRFAM Protein of
LG33_RS08450	COG1940	carbohydrate kinase activity
LG33_RS08455	COG4483	Protein conserved in bacteria
LG33_RS08465	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LG33_RS08475	COG0768	penicillin binding
LG33_RS08490	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LG33_RS08495	COG1121	(ABC) transporter
LG33_RS08505	COG0513	Belongs to the DEAD box helicase family
LG33_RS08515	COG2384	SAM-dependent methyltransferase
LG33_RS08535	COG0517	IMP dehydrogenase activity
LG33_RS08555	COG0295	cytidine deaminase activity
LG33_RS08570	COG1702	phosphate starvation-inducible protein PhoH
LG33_RS08585	COG1030	water channel activity
LG33_RS08595	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LG33_RS08600	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LG33_RS08630	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LG33_RS08650	COG1466	dna polymerase III delta subunit
LG33_RS08655	COG2333	competence protein COMEC
LG33_RS08655	COG0658	competence protein
LG33_RS08660	COG2131	deaminase
LG33_RS08670	COG2226	methyltransferase
LG33_RS08675	COG0799	negative regulation of ribosome biogenesis
LG33_RS08680	COG1713	HD superfamily hydrolase involved in NAD metabolism
LG33_RS08690	COG1534	Rna-binding protein
LG33_RS08700	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LG33_RS08705	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
LG33_RS08725	COG3177	Filamentation induced by cAMP protein fic
LG33_RS08730	COG1914	H( )-stimulated, divalent metal cation uptake system
LG33_RS08740	COG0439	Biotin carboxylase
LG33_RS08745	COG0511	ligase activity, forming carbon-carbon bonds
LG33_RS08750	COG1984	allophanate hydrolase subunit 2
LG33_RS08770	COG0826	peptidase U32
LG33_RS08775	COG0826	peptidase U32
LG33_RS08805	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LG33_RS08825	COG1104	cysteine desulfurase activity
LG33_RS08830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LG33_RS08845	COG1959	2 iron, 2 sulfur cluster binding
LG33_RS08850	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LG33_RS08855	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LG33_RS08900	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LG33_RS08900	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LG33_RS08905	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LG33_RS08905	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LG33_RS08910	COG1862	Preprotein translocase
LG33_RS08950	COG2868	ribosomal protein
LG33_RS08995	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LG33_RS09005	COG0285	dihydrofolate synthase activity
LG33_RS09015	COG2818	Glycosylase
LG33_RS09050	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LG33_RS09085	COG4112	unkown
LG33_RS09110	COG0833	amino acid
LG33_RS09125	COG1484	DNA-dependent DNA replication
LG33_RS09155	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LG33_RS09155	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LG33_RS09165	COG5002	protein histidine kinase activity
LG33_RS09170	COG0745	RESPONSE REGULATOR receiver
LG33_RS09185	COG0372	Belongs to the citrate synthase family
LG33_RS09190	COG1113	amino acid transport
LG33_RS09225	COG0281	malic enzyme
LG33_RS09235	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LG33_RS09240	COG4109	DRTGG domain
LG33_RS09280	COG0827	DNA restriction-modification system
LG33_RS09300	COG1104	cysteine desulfurase activity
LG33_RS09315	COG1956	GAF domain-containing protein
LG33_RS09330	COG0584	glycerophosphoryl diester phosphodiesterase
LG33_RS09335	COG1764	response to oxidative stress
LG33_RS09340	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LG33_RS09345	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LG33_RS09360	COG1263	PTS System
LG33_RS09360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LG33_RS09365	COG0204	Acyl-transferase
LG33_RS09370	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LG33_RS09400	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LG33_RS09405	COG0454	-acetyltransferase
LG33_RS09425	COG1605	Chorismate mutase
LG33_RS09425	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
LG33_RS09450	COG1674	ftsk spoiiie
LG33_RS09455	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LG33_RS09465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LG33_RS09470	COG1363	Peptidase, m42
LG33_RS09480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LG33_RS09490	COG0510	thiamine kinase activity
LG33_RS09520	COG1187	pseudouridine synthase activity
LG33_RS09525	COG2244	polysaccharide biosynthetic process
LG33_RS09530	COG2081	HI0933 family
LG33_RS09545	COG1388	LysM domain
LG33_RS09545	COG5632	N-Acetylmuramoyl-L-alanine amidase
LG33_RS09675	COG1783	phage Terminase large subunit
LG33_RS09770	COG0305	Participates in initiation and elongation during chromosome replication
LG33_RS09885	COG2814	Major facilitator Superfamily
LG33_RS09890	COG1242	4 iron, 4 sulfur cluster binding
LG33_RS09895	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
LG33_RS09910	COG2267	carboxylic ester hydrolase activity
LG33_RS09945	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LG33_RS09945	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LG33_RS09970	COG3266	domain, Protein
LG33_RS09970	COG4193	domain, Protein
LG33_RS09970	COG5632	N-Acetylmuramoyl-L-alanine amidase
LG33_RS10000	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LG33_RS10030	COG0656	L-ascorbic acid biosynthetic process
LG33_RS10055	COG1506	peptidase
LG33_RS10225	COG1131	(ABC) transporter
LG33_RS10340	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
LG33_RS10370	COG1131	(ABC) transporter
LG33_RS10375	COG0537	adenosine 5'-monophosphoramidase activity
LG33_RS10410	COG0420	3'-5' exonuclease activity
LG33_RS10440	COG2197	response regulator
LG33_RS10445	COG2203	Gaf domain
LG33_RS10445	COG4585	Histidine kinase
LG33_RS10450	COG0564	pseudouridine synthase activity
LG33_RS10490	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LG33_RS10495	COG1126	abc transporter atp-binding protein
LG33_RS10500	COG0765	amino acid transport
LG33_RS10675	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LG33_RS10680	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LG33_RS10690	COG4129	membrane
LG33_RS10715	COG1988	membrane-bound metal-dependent
LG33_RS10730	COG1134	teichoic acid transport
LG33_RS10730	COG1388	LysM domain
LG33_RS10760	COG0535	radical SAM domain protein
LG33_RS10765	COG1607	acyl-coa hydrolase
LG33_RS10770	COG2309	aminopeptidase activity
LG33_RS10790	COG1295	ribonuclease BN
LG33_RS10795	COG2197	response regulator
LG33_RS10915	COG4851	CamS sex pheromone cAM373 precursor
LG33_RS10925	COG0210	DNA helicase
LG33_RS10935	COG4496	protein, YerC YecD
LG33_RS10975	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LG33_RS10985	COG0077	Prephenate dehydratase
LG33_RS11005	COG1335	isochorismatase
LG33_RS11020	COG1012	belongs to the aldehyde dehydrogenase family
LG33_RS11075	COG1131	(ABC) transporter
LG33_RS11090	COG1725	Transcriptional regulator
LG33_RS11175	COG5632	N-Acetylmuramoyl-L-alanine amidase
LG33_RS11175	COG1388	LysM domain
LG33_RS11220	COG0739	heme binding
LG33_RS11270	COG0740	serine-type endopeptidase activity
LG33_RS11445	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LG33_RS11500	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LG33_RS11505	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LG33_RS11510	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LG33_RS11530	COG5484	DNA packaging
LG33_RS11530	COG3728	DNA packaging
LG33_RS11610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LG33_RS11615	COG1621	beta-fructofuranosidase activity
LG33_RS11620	COG1609	Transcriptional regulator
LG33_RS11625	COG0004	ammonium transporteR
LG33_RS11630	COG0425	Belongs to the sulfur carrier protein TusA family
LG33_RS11635	COG2391	methyltransferase activity
LG33_RS11645	COG0488	(ABC) transporter
LG33_RS11655	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LG33_RS11665	COG0456	acetyltransferase
LG33_RS11670	COG1214	PFAM Peptidase M22, glycoprotease
LG33_RS11675	COG0802	atpase or kinase
LG33_RS11690	COG0028	Belongs to the TPP enzyme family
LG33_RS11775	COG2183	response to ionizing radiation
LG33_RS11780	COG1191	sigma factor activity
LG33_RS11790	COG1366	Belongs to the anti-sigma-factor antagonist family
LG33_RS11795	COG2208	phosphoserine phosphatase activity
LG33_RS11830	COG3428	Bacterial PH domain
LG33_RS11860	COG2205	protein histidine kinase activity
LG33_RS11865	COG0745	RESPONSE REGULATOR receiver
LG33_RS11875	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LG33_RS11885	COG0772	Belongs to the SEDS family
LG33_RS11900	COG1937	Protein conserved in bacteria
LG33_RS11910	COG1418	mRNA catabolic process
LG33_RS11960	COG0629	single-stranded DNA binding
LG33_RS12035	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LG33_RS12060	COG0009	L-threonylcarbamoyladenylate synthase
LG33_RS12065	COG2890	protein-(glutamine-N5) methyltransferase activity
LG33_RS12090	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LG33_RS12130	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LG33_RS12180	COG0813	purine-nucleoside phosphorylase activity
LG33_RS12185	COG0783	Belongs to the Dps family
LG33_RS12205	COG1482	cell wall glycoprotein biosynthetic process
LG33_RS12210	COG0702	epimerase
LG33_RS12215	COG0640	Transcriptional regulator
LG33_RS12250	COG0561	phosphatase activity
LG33_RS12255	COG1119	ATPase activity
LG33_RS12270	COG3711	transcriptional antiterminator
LG33_RS12300	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
LG33_RS12370	COG0489	protein tyrosine kinase activity
LG33_RS12375	COG2814	Major facilitator Superfamily
LG33_RS12390	COG1272	protein, Hemolysin III
LG33_RS12400	COG1988	membrane-bound metal-dependent
LG33_RS12410	COG3314	Sporulation integral membrane protein YlbJ
LG33_RS12415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LG33_RS12420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LG33_RS12425	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
LG33_RS12435	COG3457	Alanine racemase
LG33_RS12440	COG4264	IucA IucC family
LG33_RS12445	COG2814	Major facilitator Superfamily
LG33_RS12480	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LG33_RS12490	COG2130	NADP-dependent
LG33_RS12535	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LG33_RS12555	COG0656	L-ascorbic acid biosynthetic process
LG33_RS12560	COG0789	Transcriptional regulator
LG33_RS12570	COG5492	domain, Protein
LG33_RS12590	COG3527	Alpha-acetolactate decarboxylase
LG33_RS12595	COG0028	Belongs to the TPP enzyme family
LG33_RS12615	COG0542	response to heat
LG33_RS12700	COG0201	protein transport
LG33_RS12815	COG2252	PERMEase
LG33_RS12860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LG33_RS12935	COG1763	Mo-molybdopterin cofactor biosynthetic process
LG33_RS12955	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LG33_RS12960	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
LG33_RS12965	COG4149	molybdate abc transporter
LG33_RS12970	COG0725	ABC transporter, periplasmic molybdate-binding protein
LG33_RS12985	COG1268	BioY protein
LG33_RS13000	COG1960	acyl-CoA dehydrogenase activity
LG33_RS13005	COG4413	Urea transporter
LG33_RS13070	COG3942	CHAP domain
LG33_RS13080	COG1757	Na H antiporter
LG33_RS13095	COG3942	CHAP domain
LG33_RS13170	COG1113	amino acid transport
LG33_RS13190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LG33_RS13195	COG0385	Bile acid
LG33_RS13205	COG1263	PTS System
LG33_RS13205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LG33_RS13210	COG1737	Transcriptional regulator
LG33_RS13230	COG1028	Short-chain dehydrogenase reductase Sdr
LG33_RS13235	COG1473	amidohydrolase
LG33_RS13250	COG0583	DNA-binding transcription factor activity
LG33_RS13275	COG2258	MOSC domain
LG33_RS13295	COG1668	transmembrane transport
LG33_RS13300	COG4152	abc transporter atp-binding protein
LG33_RS13305	COG3152	Membrane
LG33_RS13320	COG0786	glutamate:sodium symporter activity
LG33_RS13330	COG0598	Magnesium transport protein CorA
LG33_RS13345	COG0657	acetylesterase activity
LG33_RS13355	COG2814	Major facilitator Superfamily
LG33_RS13360	COG1566	PFAM secretion protein HlyD family protein
LG33_RS13370	COG2814	Major facilitator Superfamily
LG33_RS13440	COG1620	l-lactate permease
LG33_RS13460	COG0604	alcohol dehydrogenase
LG33_RS13465	COG0456	acetyltransferase
LG33_RS13490	COG1511	domain protein
LG33_RS13505	COG1263	PTS System
LG33_RS13505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LG33_RS13520	COG3871	stress protein (general stress protein 26)
LG33_RS13565	COG0789	Transcriptional regulator
LG33_RS13585	COG2181	nitrate reductase activity
LG33_RS13595	COG1140	nitrate reductase beta subunit
LG33_RS13600	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
LG33_RS13610	COG2146	nitrite reductase [NAD(P)H] activity
LG33_RS13615	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LG33_RS13625	COG0454	-acetyltransferase
LG33_RS13630	COG2116	formate transmembrane transporter activity
LG33_RS13645	COG3443	Belongs to the bacterial solute-binding protein 9 family
LG33_RS13645	COG0803	Belongs to the bacterial solute-binding protein 9 family
LG33_RS13680	COG1126	abc transporter atp-binding protein
LG33_RS13685	COG0765	amino acid transport
LG33_RS13690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LG33_RS13695	COG2814	Major facilitator Superfamily
LG33_RS13715	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
LG33_RS13765	COG0156	8-amino-7-oxononanoate synthase activity
LG33_RS13775	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LG33_RS13780	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LG33_RS13795	COG1132	(ABC) transporter
LG33_RS13800	COG2375	cellular response to nickel ion
LG33_RS13800	COG1132	(ABC) transporter
LG33_RS13825	COG1929	Belongs to the glycerate kinase type-1 family
LG33_RS13835	COG2814	Major facilitator Superfamily
LG33_RS13855	COG1113	amino acid transport
LG33_RS13870	COG0531	amino acid
LG33_RS13895	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LG33_RS13905	COG1174	glycine betaine transport
LG33_RS13915	COG1174	glycine betaine transport
LG33_RS13935	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
LG33_RS13945	COG0531	amino acid
LG33_RS13955	COG2272	Belongs to the type-B carboxylesterase lipase family
LG33_RS13960	COG2814	Major facilitator Superfamily
LG33_RS13965	COG0390	transport system, permease component
LG33_RS13970	COG4619	ABC transporter
LG33_RS13975	COG1363	Peptidase, m42
LG33_RS13995	COG4808	Protein conserved in bacteria
LG33_RS14000	COG0069	glutamate synthase activity
LG33_RS14015	COG1124	(ABC) transporter
LG33_RS14020	COG0444	Belongs to the ABC transporter superfamily
LG33_RS14025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LG33_RS14030	COG0601	transmembrane transport
LG33_RS14035	COG0747	negative chemotaxis
LG33_RS14070	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
LG33_RS14075	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LG33_RS14160	COG0494	nUDIX hydrolase
LG33_RS14200	COG1846	Transcriptional regulator
LG33_RS14205	COG1846	Transcriptional regulator
LG33_RS14240	COG1070	Carbohydrate kinase
LG33_RS14245	COG1802	Transcriptional regulator
LG33_RS14250	COG0789	Transcriptional regulator
LG33_RS14255	COG2357	RelA SpoT domain protein
LG33_RS14260	COG4876	unkown
LG33_RS14270	COG2271	Major facilitator Superfamily
LG33_RS14275	COG0586	Pfam SNARE associated Golgi protein
LG33_RS14285	COG2814	Major facilitator Superfamily
LG33_RS14290	COG1846	Transcriptional regulator
LG33_RS14300	COG1131	(ABC) transporter
LG33_RS14315	COG3949	Membrane
LG33_RS14320	COG0400	carboxylic ester hydrolase activity
LG33_RS14325	COG0346	lactoylglutathione lyase activity
LG33_RS14330	COG1846	Transcriptional regulator
LG33_RS14340	COG2514	catechol 2,3-dioxygenase activity
LG33_RS14355	COG0561	phosphatase activity
LG33_RS14360	COG1131	(ABC) transporter
LG33_RS14370	COG3764	Sortase (surface protein transpeptidase)
LG33_RS14390	COG1760	l-serine dehydratase
LG33_RS14395	COG1760	l-serine dehydratase
LG33_RS14410	COG0697	spore germination
LG33_RS14415	COG0657	acetylesterase activity
LG33_RS14435	COG0028	Belongs to the TPP enzyme family
LG33_RS14450	COG0583	DNA-binding transcription factor activity
LG33_RS14460	COG3942	CHAP domain
LG33_RS14485	COG3425	synthase
LG33_RS14490	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LG33_RS14495	COG0542	response to heat
LG33_RS14515	COG2409	Drug exporters of the RND superfamily
LG33_RS14560	COG0436	Aminotransferase
LG33_RS14590	COG3942	CHAP domain
LG33_RS14595	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LG33_RS14595	COG2755	lipolytic protein G-D-S-L family
LG33_RS14710	COG3001	Fructosamine kinase
LG33_RS14715	COG0167	dihydroorotate dehydrogenase activity
LG33_RS14765	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LG33_RS14770	COG3527	Alpha-acetolactate decarboxylase
LG33_RS14785	COG0531	amino acid
LG33_RS14815	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LG33_RS14835	COG1012	belongs to the aldehyde dehydrogenase family
LG33_RS14845	COG1510	regulation of RNA biosynthetic process
LG33_RS14860	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LG33_RS14885	COG2851	Citrate transporter
LG33_RS14900	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LG33_RS14910	COG0386	Belongs to the glutathione peroxidase family
LG33_RS14935	COG1136	(ABC) transporter
LG33_RS14940	COG2205	protein histidine kinase activity
LG33_RS14945	COG0745	RESPONSE REGULATOR receiver
LG33_RS14955	COG1785	Belongs to the alkaline phosphatase family
LG33_RS14965	COG1846	Transcriptional regulator
LG33_RS15010	COG1438	arginine binding
LG33_RS15030	COG3711	transcriptional antiterminator
LG33_RS15030	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LG33_RS15035	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LG33_RS15035	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LG33_RS15035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LG33_RS15040	COG1482	cell wall glycoprotein biosynthetic process
LG33_RS15050	COG3942	CHAP domain
LG33_RS15050	COG1705	Flagellar rod assembly protein muramidase FlgJ
LG33_RS15055	COG3433	isochorismatase activity
LG33_RS15055	COG1535	isochorismatase
LG33_RS15070	COG0438	transferase activity, transferring glycosyl groups
LG33_RS15085	COG1073	alpha beta
LG33_RS15105	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LG33_RS15125	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LG33_RS15185	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
LG33_RS15220	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LG33_RS15305	COG0471	metal ion transport
LG33_RS15310	COG2962	Rard protein
LG33_RS15320	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
LG33_RS15335	COG1136	(ABC) transporter
LG33_RS15340	COG0577	efflux transmembrane transporter activity
LG33_RS15375	COG1278	Cold shock
LG33_RS15400	COG1475	DNA binding
LG33_RS15460	COG0456	acetyltransferase
LG33_RS15490	COG3682	Transcriptional regulator
LG33_RS15510	COG0604	alcohol dehydrogenase
LG33_RS15555	COG3093	addiction module antidote protein HigA
LG33_RS15570	COG3173	Aminoglycoside phosphotransferase
LG33_RS15605	COG1968	undecaprenyl-diphosphatase activity