locus-tag	class	description
MKI63_RS00015	COG2501	S4 domain
MKI63_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MKI63_RS00060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MKI63_RS00070	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
MKI63_RS00080	COG0305	Participates in initiation and elongation during chromosome replication
MKI63_RS00110	COG4863	YycH protein
MKI63_RS00120	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MKI63_RS00125	COG0737	Belongs to the 5'-nucleotidase family
MKI63_RS00150	COG3425	synthase
MKI63_RS00155	COG0584	glycerophosphoryl diester phosphodiesterase
MKI63_RS00160	COG2030	dehydratase
MKI63_RS00230	COG3732	PTS system glucitol sorbitol-specific
MKI63_RS00235	COG3730	PTS system glucitol sorbitol-specific
MKI63_RS00310	COG0730	response to heat
MKI63_RS00315	COG1937	Protein conserved in bacteria
MKI63_RS00320	COG2210	Belongs to the sulfur carrier protein TusA family
MKI63_RS00325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MKI63_RS00365	COG0823	Involved in the tonB-independent uptake of proteins
MKI63_RS00400	COG1473	amidohydrolase
MKI63_RS00410	COG1283	sodium-dependent phosphate transmembrane transporter activity
MKI63_RS00415	COG4716	Myosin-crossreactive antigen
MKI63_RS00420	COG0697	spore germination
MKI63_RS00435	COG1620	l-lactate permease
MKI63_RS00450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MKI63_RS00455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MKI63_RS00460	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MKI63_RS00470	COG2423	ornithine cyclodeaminase activity
MKI63_RS00475	COG4264	IucA IucC family
MKI63_RS00480	COG2814	Major facilitator Superfamily
MKI63_RS00485	COG4264	IucA IucC family
MKI63_RS00490	COG4264	IucA IucC family
MKI63_RS00500	COG0019	diaminopimelate decarboxylase activity
MKI63_RS00505	COG1475	DNA binding
MKI63_RS00525	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MKI63_RS00530	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MKI63_RS00535	COG0438	transferase activity, transferring glycosyl groups
MKI63_RS00570	COG0813	purine-nucleoside phosphorylase activity
MKI63_RS00575	COG2814	Major facilitator Superfamily
MKI63_RS00595	COG3639	organic phosphonate transmembrane transporter activity
MKI63_RS00615	COG0737	Belongs to the 5'-nucleotidase family
MKI63_RS00630	COG1454	alcohol dehydrogenase
MKI63_RS00630	COG1012	belongs to the aldehyde dehydrogenase family
MKI63_RS00655	COG1086	Polysaccharide biosynthesis protein
MKI63_RS00665	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MKI63_RS00695	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MKI63_RS00705	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
MKI63_RS00710	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MKI63_RS00720	COG2832	Protein of unknown function (DUF454)
MKI63_RS00755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MKI63_RS00760	COG1960	acyl-CoA dehydrogenase activity
MKI63_RS00765	COG5609	conserved protein (DUF2294)
MKI63_RS00815	COG1114	Component of the transport system for branched-chain amino acids
MKI63_RS00820	COG1335	isochorismatase
MKI63_RS00825	COG3961	Belongs to the TPP enzyme family
MKI63_RS00855	COG1737	Transcriptional regulator
MKI63_RS00880	COG1136	(ABC) transporter
MKI63_RS00885	COG1136	(ABC) transporter
MKI63_RS00885	COG0577	efflux transmembrane transporter activity
MKI63_RS00905	COG1131	(ABC) transporter
MKI63_RS00925	COG0601	transmembrane transport
MKI63_RS00930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MKI63_RS00940	COG0405	Gamma-glutamyltransferase
MKI63_RS00960	COG3842	ATPase activity
MKI63_RS00970	COG1175	transmembrane transport
MKI63_RS00975	COG3833	ABC-type maltose transport systems, permease component
MKI63_RS00980	COG0673	inositol 2-dehydrogenase activity
MKI63_RS00985	COG0673	inositol 2-dehydrogenase activity
MKI63_RS00995	COG1755	Isoprenylcysteine carboxyl methyltransferase
MKI63_RS01050	COG0183	Belongs to the thiolase family
MKI63_RS01060	COG1960	acyl-CoA dehydrogenase activity
MKI63_RS01065	COG0318	PFAM AMP-dependent synthetase and ligase
MKI63_RS01080	COG0747	negative chemotaxis
MKI63_RS01085	COG3189	MarR family transcriptional regulator
MKI63_RS01110	COG1263	PTS System
MKI63_RS01110	COG2190	(PTS) system
MKI63_RS01110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MKI63_RS01115	COG1957	nucleoside hydrolase
MKI63_RS01135	COG3414	Phosphotransferase system galactitol-specific IIB component
MKI63_RS01140	COG3775	system Galactitol-specific IIC component
MKI63_RS01145	COG1063	alcohol dehydrogenase
MKI63_RS01155	COG1063	alcohol dehydrogenase
MKI63_RS01165	COG1063	alcohol dehydrogenase
MKI63_RS01170	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MKI63_RS01175	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MKI63_RS01185	COG1063	alcohol dehydrogenase
MKI63_RS01190	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MKI63_RS01225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MKI63_RS01230	COG2190	(PTS) system
MKI63_RS01230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MKI63_RS01230	COG1263	PTS System
MKI63_RS01235	COG2723	6-phospho-beta-galactosidase activity
MKI63_RS01240	COG2226	methyltransferase
MKI63_RS01295	COG1131	(ABC) transporter
MKI63_RS01315	COG1388	LysM domain
MKI63_RS01315	COG3942	CHAP domain
MKI63_RS01435	COG1114	Component of the transport system for branched-chain amino acids
MKI63_RS01440	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
MKI63_RS01445	COG0577	efflux transmembrane transporter activity
MKI63_RS01475	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MKI63_RS01480	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MKI63_RS01505	COG3314	Sporulation integral membrane protein YlbJ
MKI63_RS01530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MKI63_RS01560	COG3037	sugar-specific permease SgaT UlaA
MKI63_RS01570	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MKI63_RS01575	COG3711	transcriptional antiterminator
MKI63_RS01595	COG2271	Major facilitator Superfamily
MKI63_RS01600	COG0346	lactoylglutathione lyase activity
MKI63_RS01605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MKI63_RS01610	COG0431	NADPH-dependent FMN reductase
MKI63_RS01620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MKI63_RS01625	COG2822	iron ion transport
MKI63_RS01635	COG0672	)-iron permease
MKI63_RS01640	COG0805	protein transport
MKI63_RS01645	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MKI63_RS01655	COG1476	TRANSCRIPTIONal
MKI63_RS01695	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MKI63_RS01695	COG0646	methionine synthase
MKI63_RS01700	COG0626	cystathionine gamma-synthase activity
MKI63_RS01705	COG0626	cystathionine gamma-synthase activity
MKI63_RS01710	COG1475	DNA binding
MKI63_RS01715	COG0668	transmembrane transport
MKI63_RS01720	COG4481	Protein conserved in bacteria
MKI63_RS01725	COG0012	GTP binding
MKI63_RS01835	COG1823	symporter activity
MKI63_RS01865	COG2233	PERMEase
MKI63_RS01900	COG3759	membrane
MKI63_RS02060	COG0523	cobalamin synthesis protein
MKI63_RS02085	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MKI63_RS02095	COG5609	conserved protein (DUF2294)
MKI63_RS02110	COG1647	Serine aminopeptidase, S33
MKI63_RS02115	COG0733	neurotransmitter:sodium symporter activity
MKI63_RS02120	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MKI63_RS02125	COG0626	cystathionine gamma-synthase activity
MKI63_RS02135	COG2011	ABC-type metal ion transport system permease component
MKI63_RS02140	COG1464	Belongs to the NlpA lipoprotein family
MKI63_RS02175	COG0583	DNA-binding transcription factor activity
MKI63_RS02180	COG0070	glutamate synthase
MKI63_RS02180	COG0069	glutamate synthase activity
MKI63_RS02180	COG0067	glutamate synthase
MKI63_RS02185	COG0493	'glutamate synthase
MKI63_RS02195	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MKI63_RS02195	COG1263	PTS System
MKI63_RS02200	COG0366	Alpha amylase catalytic
MKI63_RS02205	COG2188	Transcriptional regulator
MKI63_RS02225	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MKI63_RS02260	COG1982	Orn Lys Arg decarboxylase major
MKI63_RS02270	COG3870	Protein conserved in bacteria
MKI63_RS02275	COG0470	DNA polymerase III
MKI63_RS02280	COG1774	PSP1 C-terminal conserved region
MKI63_RS02290	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MKI63_RS02300	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MKI63_RS02310	COG0084	hydrolase, TatD family'
MKI63_RS02315	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
MKI63_RS02325	COG4466	Protein conserved in bacteria
MKI63_RS02335	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MKI63_RS02340	COG0251	oxidation-reduction process
MKI63_RS02380	COG2244	polysaccharide biosynthetic process
MKI63_RS02385	COG3956	TIGRFAM MazG family protein
MKI63_RS02390	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MKI63_RS02400	COG1098	S1 RNA binding domain
MKI63_RS02415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MKI63_RS02440	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MKI63_RS02535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MKI63_RS02550	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MKI63_RS02560	COG3880	PFAM UvrB UvrC protein
MKI63_RS02575	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MKI63_RS02580	COG4956	integral membrane protein (PIN domain superfamily)
MKI63_RS02600	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
MKI63_RS02655	COG2813	Specifically methylates the guanine in position
MKI63_RS02695	COG1473	amidohydrolase
MKI63_RS02725	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MKI63_RS02730	COG1428	Deoxynucleoside kinase
MKI63_RS02735	COG1428	Deoxynucleoside kinase
MKI63_RS02745	COG0561	phosphatase activity
MKI63_RS02785	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MKI63_RS02800	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
MKI63_RS02890	COG0095	Lipoate-protein ligase
MKI63_RS02895	COG0083	homoserine kinase activity
MKI63_RS02915	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MKI63_RS02950	COG0667	Aldo Keto reductase
MKI63_RS02955	COG0655	NAD(P)H dehydrogenase (quinone) activity
MKI63_RS02965	COG1078	dGTPase activity
MKI63_RS03000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MKI63_RS03005	COG4139	cobalamin transport
MKI63_RS03055	COG4974	Belongs to the 'phage' integrase family
MKI63_RS03110	COG0803	Belongs to the bacterial solute-binding protein 9 family
MKI63_RS03115	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MKI63_RS03120	COG1121	(ABC) transporter
MKI63_RS03125	COG1321	iron dependent repressor
MKI63_RS03135	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
MKI63_RS03145	COG1682	transport, permease protein
MKI63_RS03150	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MKI63_RS03160	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MKI63_RS03165	COG1686	Belongs to the peptidase S11 family
MKI63_RS03170	COG1132	(ABC) transporter
MKI63_RS03175	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MKI63_RS03185	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MKI63_RS03190	COG1120	ATPase activity
MKI63_RS03195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MKI63_RS03200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MKI63_RS03205	COG2376	Dihydroxyacetone kinase
MKI63_RS03215	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
MKI63_RS03225	COG3949	Membrane
MKI63_RS03245	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MKI63_RS03260	COG1136	(ABC) transporter
MKI63_RS03265	COG0577	efflux transmembrane transporter activity
MKI63_RS03270	COG1392	Phosphate transport regulator
MKI63_RS03275	COG0306	phosphate transporter
MKI63_RS03280	COG1388	LysM domain
MKI63_RS03280	COG3942	CHAP domain
MKI63_RS03290	COG4977	sequence-specific DNA binding
MKI63_RS03290	COG1917	Cupin 2, conserved barrel domain protein
MKI63_RS03320	COG0583	DNA-binding transcription factor activity
MKI63_RS03325	COG2814	Major facilitator Superfamily
MKI63_RS03330	COG2839	Protein conserved in bacteria
MKI63_RS03360	COG1611	Belongs to the LOG family
MKI63_RS03380	COG4988	ABC transporter
MKI63_RS03385	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MKI63_RS03395	COG0523	cobalamin synthesis protein
MKI63_RS03400	COG4989	oxidoreductase activity
MKI63_RS03410	COG0471	metal ion transport
MKI63_RS03415	COG0415	Belongs to the DNA photolyase family
MKI63_RS03445	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MKI63_RS03450	COG1349	DNA-binding transcription factor activity
MKI63_RS03455	COG1105	Belongs to the carbohydrate kinase PfkB family
MKI63_RS03465	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MKI63_RS03470	COG1253	flavin adenine dinucleotide binding
MKI63_RS03475	COG0656	L-ascorbic acid biosynthetic process
MKI63_RS03480	COG0463	Glycosyl transferase, family 2
MKI63_RS03515	COG0720	synthase
MKI63_RS03525	COG0512	Glutamine amidotransferase of anthranilate synthase
MKI63_RS03525	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MKI63_RS03530	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MKI63_RS03560	COG0488	(ABC) transporter
MKI63_RS03565	COG0514	ATP-dependent DNA helicase (RecQ)
MKI63_RS03570	COG0517	IMP dehydrogenase activity
MKI63_RS03570	COG1125	glycine betaine transport
MKI63_RS03575	COG1174	glycine betaine transport
MKI63_RS03600	COG3104	oligopeptide transport
MKI63_RS03625	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MKI63_RS03630	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MKI63_RS03640	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MKI63_RS03645	COG4605	iron ion homeostasis
MKI63_RS03650	COG4604	ABC transporter, ATP-binding protein
MKI63_RS03655	COG4607	ABC-type enterochelin transport system periplasmic component
MKI63_RS03710	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MKI63_RS03715	COG1739	Uncharacterized protein family UPF0029
MKI63_RS03725	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
MKI63_RS03730	COG1040	competence protein
MKI63_RS03760	COG3942	CHAP domain
MKI63_RS03760	COG1388	LysM domain
MKI63_RS03815	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MKI63_RS03875	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MKI63_RS03880	COG1647	Serine aminopeptidase, S33
MKI63_RS03885	COG0557	exoribonuclease II activity
MKI63_RS03985	COG3728	DNA packaging
MKI63_RS03985	COG5484	DNA packaging
MKI63_RS04020	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MKI63_RS04025	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MKI63_RS04085	COG1278	Cold shock
MKI63_RS04125	COG0406	alpha-ribazole phosphatase activity
MKI63_RS04130	COG1279	arginine transmembrane transporter activity
MKI63_RS04155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MKI63_RS04160	COG1393	Belongs to the ArsC family
MKI63_RS04170	COG3878	Protein conserved in bacteria
MKI63_RS04175	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
MKI63_RS04190	COG2011	ABC-type metal ion transport system permease component
MKI63_RS04195	COG1464	Belongs to the NlpA lipoprotein family
MKI63_RS04210	COG0396	ATPase activity
MKI63_RS04215	COG0719	Fe-S assembly protein
MKI63_RS04225	COG0822	iron-sulfur transferase activity
MKI63_RS04245	COG1253	flavin adenine dinucleotide binding
MKI63_RS04260	COG1801	Protein of unknown function DUF72
MKI63_RS04265	COG0730	response to heat
MKI63_RS04280	COG4470	Protein conserved in bacteria
MKI63_RS04300	COG2445	Protein of unknown function DUF86
MKI63_RS04330	COG1696	Membrane protein involved in D-alanine export
MKI63_RS04340	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
MKI63_RS04345	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
MKI63_RS04350	COG4837	Protein of unknown function (DUF1462)
MKI63_RS04355	COG1252	NADH dehydrogenase
MKI63_RS04365	COG0316	Belongs to the HesB IscA family
MKI63_RS04375	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MKI63_RS04380	COG2056	Na+-H+ antiporter family
MKI63_RS04385	COG2050	protein possibly involved in aromatic compounds catabolism
MKI63_RS04440	COG1098	S1 RNA binding domain
MKI63_RS04445	COG1902	pentaerythritol trinitrate reductase activity
MKI63_RS04460	COG0584	glycerophosphoryl diester phosphodiesterase
MKI63_RS04480	COG0398	Pfam SNARE associated Golgi protein
MKI63_RS04520	COG0561	phosphatase activity
MKI63_RS04560	COG1881	PFAM PEBP family protein
MKI63_RS04590	COG0601	transmembrane transport
MKI63_RS04595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MKI63_RS04600	COG0444	Belongs to the ABC transporter superfamily
MKI63_RS04605	COG4608	Belongs to the ABC transporter superfamily
MKI63_RS04610	COG4166	transmembrane transport
MKI63_RS04615	COG0747	negative chemotaxis
MKI63_RS04620	COG0444	Belongs to the ABC transporter superfamily
MKI63_RS04625	COG4608	Belongs to the ABC transporter superfamily
MKI63_RS04630	COG0601	transmembrane transport
MKI63_RS04635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MKI63_RS04660	COG1164	Oligoendopeptidase f
MKI63_RS04670	COG2346	COG2346, Truncated hemoglobins
MKI63_RS04685	COG2357	RelA SpoT domain protein
MKI63_RS04695	COG0564	pseudouridine synthase activity
MKI63_RS04700	COG2239	Acts as a magnesium transporter
MKI63_RS04705	COG0475	glutathione-regulated potassium exporter activity
MKI63_RS04705	COG0569	domain protein
MKI63_RS04725	COG0628	permease
MKI63_RS04730	COG1115	amino acid carrier protein
MKI63_RS04770	COG0861	Integral membrane protein TerC family
MKI63_RS04790	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MKI63_RS04795	COG0737	Belongs to the 5'-nucleotidase family
MKI63_RS04810	COG4903	ComK protein
MKI63_RS04825	COG4873	Protein conserved in bacteria
MKI63_RS04880	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
MKI63_RS04890	COG2314	TM2 domain
MKI63_RS04895	COG0456	acetyltransferase
MKI63_RS04900	COG1575	Belongs to the MenA family. Type 1 subfamily
MKI63_RS04910	COG1169	isochorismate synthase
MKI63_RS04920	COG2267	carboxylic ester hydrolase activity
MKI63_RS04945	COG0436	Aminotransferase
MKI63_RS04950	COG3594	Acyltransferase
MKI63_RS04980	COG1316	TRANSCRIPTIONal
MKI63_RS05025	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MKI63_RS05040	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MKI63_RS05080	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MKI63_RS05085	COG4172	Belongs to the ABC transporter superfamily
MKI63_RS05090	COG4721	ABC-type cobalt transport system, permease component
MKI63_RS05105	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MKI63_RS05125	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MKI63_RS05130	COG1271	oxidase subunit
MKI63_RS05135	COG1294	oxidase, subunit
MKI63_RS05140	COG0569	domain protein
MKI63_RS05205	COG1176	ABC-type spermidine putrescine transport system, permease component I
MKI63_RS05210	COG1177	transmembrane transport
MKI63_RS05215	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
MKI63_RS05240	COG0483	inositol monophosphate 1-phosphatase activity
MKI63_RS05250	COG1217	gtp-binding protein TYPA
MKI63_RS05260	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MKI63_RS05270	COG0772	Belongs to the SEDS family
MKI63_RS05300	COG3679	Belongs to the UPF0342 family
MKI63_RS05320	COG0742	ribosomal rna small subunit methyltransferase
MKI63_RS05375	COG4509	Sortase family
MKI63_RS05390	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MKI63_RS05420	COG1796	DNA polymerase
MKI63_RS05420	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MKI63_RS05445	COG2009	succinate dehydrogenase
MKI63_RS05450	COG1053	succinate dehydrogenase
MKI63_RS05455	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MKI63_RS05570	COG1288	antiporter activity
MKI63_RS05605	COG1011	Hydrolase
MKI63_RS05630	COG4839	cell division protein FtsL
MKI63_RS05635	COG0768	penicillin binding
MKI63_RS05650	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MKI63_RS05655	COG0849	cell division
MKI63_RS05670	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MKI63_RS05680	COG0762	integral membrane protein
MKI63_RS05685	COG2302	S4 RNA-binding domain
MKI63_RS05690	COG3599	regulation of cell shape
MKI63_RS05700	COG2514	catechol 2,3-dioxygenase activity
MKI63_RS05715	COG0564	pseudouridine synthase activity
MKI63_RS05725	COG2233	PERMEase
MKI63_RS05770	COG1293	RNA-binding protein homologous to eukaryotic snRNP
MKI63_RS05785	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MKI63_RS05790	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MKI63_RS05800	COG2314	TM2 domain
MKI63_RS05815	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MKI63_RS05815	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MKI63_RS05825	COG0631	protein serine/threonine phosphatase activity
MKI63_RS05840	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MKI63_RS05855	COG1302	Protein conserved in bacteria
MKI63_RS05900	COG1196	nuclear chromosome segregation
MKI63_RS05905	COG0552	protein localization to endoplasmic reticulum
MKI63_RS05915	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MKI63_RS05970	COG2348	transferase activity, transferring amino-acyl groups
MKI63_RS05975	COG0758	DNA mediated transformation
MKI63_RS06070	COG0195	Participates in both transcription termination and antitermination
MKI63_RS06075	COG2740	Nucleic-acid-binding protein implicated in transcription termination
MKI63_RS06100	COG0196	riboflavin kinase activity
MKI63_RS06125	COG2188	Transcriptional regulator
MKI63_RS06130	COG0612	Peptidase, M16
MKI63_RS06135	COG0612	Peptidase, M16
MKI63_RS06140	COG0300	oxidoreductase activity
MKI63_RS06160	COG1058	Belongs to the CinA family
MKI63_RS06160	COG1546	Belongs to the CinA family
MKI63_RS06180	COG1692	metallophosphoesterase
MKI63_RS06185	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MKI63_RS06185	COG0674	pyruvate-flavodoxin oxidoreductase activity
MKI63_RS06190	COG1013	pyruvate-flavodoxin oxidoreductase activity
MKI63_RS06225	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
MKI63_RS06230	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MKI63_RS06255	COG1923	regulation of RNA biosynthetic process
MKI63_RS06265	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MKI63_RS06270	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
MKI63_RS06275	COG0789	Transcriptional regulator
MKI63_RS06345	COG1131	(ABC) transporter
MKI63_RS06360	COG2197	response regulator
MKI63_RS06370	COG1525	nuclease
MKI63_RS06385	COG0527	aspartate kinase activity
MKI63_RS06390	COG0460	homoserine dehydrogenase
MKI63_RS06395	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MKI63_RS06420	COG0833	amino acid
MKI63_RS06450	COG2340	Cysteine-rich secretory protein family
MKI63_RS06485	COG4846	Membrane protein involved in cytochrome C biogenesis
MKI63_RS06505	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MKI63_RS06515	COG0824	Thioesterase
MKI63_RS06540	COG1115	amino acid carrier protein
MKI63_RS06555	COG0628	permease
MKI63_RS06580	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MKI63_RS06590	COG1363	Peptidase, m42
MKI63_RS06595	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MKI63_RS06600	COG0512	Glutamine amidotransferase of anthranilate synthase
MKI63_RS06645	COG0561	phosphatase activity
MKI63_RS06690	COG0704	Plays a role in the regulation of phosphate uptake
MKI63_RS06700	COG0581	inorganic phosphate transmembrane transporter activity
MKI63_RS06705	COG0573	inorganic phosphate transmembrane transporter activity
MKI63_RS06725	COG0488	(ABC) transporter
MKI63_RS06730	COG0527	aspartate kinase activity
MKI63_RS06735	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MKI63_RS06805	COG4548	von Willebrand factor, type A
MKI63_RS06810	COG0714	Associated with various cellular activities
MKI63_RS06855	COG0671	phosphoesterase, PA-phosphatase related
MKI63_RS06930	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
MKI63_RS06950	COG0531	amino acid
MKI63_RS06965	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MKI63_RS06970	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
MKI63_RS06985	COG0116	Belongs to the methyltransferase superfamily
MKI63_RS07020	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MKI63_RS07020	COG4499	WXG100 protein secretion system (Wss), protein YukC
MKI63_RS07030	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MKI63_RS07035	COG3935	DnaD domain protein
MKI63_RS07060	COG0438	transferase activity, transferring glycosyl groups
MKI63_RS07065	COG1694	Mazg nucleotide pyrophosphohydrolase
MKI63_RS07070	COG2738	Putative neutral zinc metallopeptidase
MKI63_RS07075	COG4347	Protein of unknown function (DUF1405)
MKI63_RS07115	COG0142	geranyltranstransferase activity
MKI63_RS07170	COG0492	ferredoxin-NADP+ reductase activity
MKI63_RS07185	COG0514	ATP-dependent DNA helicase (RecQ)
MKI63_RS07195	COG1141	Ferredoxin
MKI63_RS07240	COG0745	RESPONSE REGULATOR receiver
MKI63_RS07245	COG1187	pseudouridine synthase activity
MKI63_RS07270	COG0735	belongs to the Fur family
MKI63_RS07275	COG0494	nUDIX hydrolase
MKI63_RS07280	COG0667	Aldo Keto reductase
MKI63_RS07290	COG4221	oxidoreductase activity
MKI63_RS07305	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MKI63_RS07315	COG0366	Alpha amylase catalytic
MKI63_RS07320	COG1609	Transcriptional regulator
MKI63_RS07345	COG2195	Cleaves the N-terminal amino acid of tripeptides
MKI63_RS07355	COG4129	membrane
MKI63_RS07365	COG0508	dehydrogenase complex catalyzes the overall conversion of
MKI63_RS07370	COG0022	dehydrogenase e1 component
MKI63_RS07375	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MKI63_RS07380	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MKI63_RS07385	COG0497	DNA recombination
MKI63_RS07415	COG1302	Protein conserved in bacteria
MKI63_RS07420	COG0439	Biotin carboxylase
MKI63_RS07425	COG0511	ligase activity, forming carbon-carbon bonds
MKI63_RS07435	COG0006	proline dipeptidase activity
MKI63_RS07450	COG0095	Lipoate-protein ligase
MKI63_RS07455	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MKI63_RS07500	COG4537	Required for transformation and DNA binding
MKI63_RS07505	COG1459	type II secretion system
MKI63_RS07510	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MKI63_RS07515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MKI63_RS07520	COG0011	TIGRFAM Protein of
MKI63_RS07525	COG1940	carbohydrate kinase activity
MKI63_RS07530	COG4483	Protein conserved in bacteria
MKI63_RS07540	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MKI63_RS07550	COG0768	penicillin binding
MKI63_RS07565	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MKI63_RS07570	COG1121	(ABC) transporter
MKI63_RS07580	COG0513	Belongs to the DEAD box helicase family
MKI63_RS07590	COG2384	SAM-dependent methyltransferase
MKI63_RS07610	COG0517	IMP dehydrogenase activity
MKI63_RS07630	COG0295	cytidine deaminase activity
MKI63_RS07645	COG1702	phosphate starvation-inducible protein PhoH
MKI63_RS07660	COG1030	water channel activity
MKI63_RS07670	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MKI63_RS07675	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MKI63_RS07705	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MKI63_RS07720	COG1466	dna polymerase III delta subunit
MKI63_RS07725	COG2333	competence protein COMEC
MKI63_RS07725	COG0658	competence protein
MKI63_RS07730	COG2131	deaminase
MKI63_RS07735	COG2183	response to ionizing radiation
MKI63_RS07740	COG2226	methyltransferase
MKI63_RS07745	COG0799	negative regulation of ribosome biogenesis
MKI63_RS07750	COG1713	HD superfamily hydrolase involved in NAD metabolism
MKI63_RS07760	COG1534	Rna-binding protein
MKI63_RS07770	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MKI63_RS07775	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
MKI63_RS07795	COG3177	Filamentation induced by cAMP protein fic
MKI63_RS07800	COG1914	H( )-stimulated, divalent metal cation uptake system
MKI63_RS07810	COG0439	Biotin carboxylase
MKI63_RS07815	COG0511	ligase activity, forming carbon-carbon bonds
MKI63_RS07820	COG1984	allophanate hydrolase subunit 2
MKI63_RS07825	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MKI63_RS07840	COG0826	peptidase U32
MKI63_RS07845	COG0826	peptidase U32
MKI63_RS07875	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MKI63_RS07890	COG1104	cysteine desulfurase activity
MKI63_RS07895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MKI63_RS07905	COG3237	CsbD-like
MKI63_RS07910	COG1959	2 iron, 2 sulfur cluster binding
MKI63_RS07915	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MKI63_RS07920	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MKI63_RS07965	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
MKI63_RS07965	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MKI63_RS07970	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MKI63_RS07970	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MKI63_RS07975	COG1862	Preprotein translocase
MKI63_RS08015	COG2868	ribosomal protein
MKI63_RS08060	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
MKI63_RS08065	COG0285	dihydrofolate synthase activity
MKI63_RS08075	COG2818	Glycosylase
MKI63_RS08110	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MKI63_RS08145	COG4112	unkown
MKI63_RS08165	COG0833	amino acid
MKI63_RS08180	COG1484	DNA-dependent DNA replication
MKI63_RS08210	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MKI63_RS08210	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MKI63_RS08220	COG5002	protein histidine kinase activity
MKI63_RS08225	COG0745	RESPONSE REGULATOR receiver
MKI63_RS08235	COG0372	Belongs to the citrate synthase family
MKI63_RS08240	COG1113	amino acid transport
MKI63_RS08265	COG0281	malic enzyme
MKI63_RS08275	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MKI63_RS08280	COG4109	DRTGG domain
MKI63_RS08320	COG0827	DNA restriction-modification system
MKI63_RS08330	COG0730	response to heat
MKI63_RS08340	COG1104	cysteine desulfurase activity
MKI63_RS08355	COG1956	GAF domain-containing protein
MKI63_RS08365	COG0584	glycerophosphoryl diester phosphodiesterase
MKI63_RS08370	COG1764	response to oxidative stress
MKI63_RS08375	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MKI63_RS08380	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MKI63_RS08395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MKI63_RS08395	COG1263	PTS System
MKI63_RS08400	COG0204	Acyl-transferase
MKI63_RS08405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MKI63_RS08440	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MKI63_RS08445	COG0454	-acetyltransferase
MKI63_RS08465	COG1605	Chorismate mutase
MKI63_RS08465	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MKI63_RS08490	COG1674	ftsk spoiiie
MKI63_RS08495	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MKI63_RS08505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MKI63_RS08510	COG1363	Peptidase, m42
MKI63_RS08520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MKI63_RS08530	COG0510	thiamine kinase activity
MKI63_RS08550	COG1187	pseudouridine synthase activity
MKI63_RS08555	COG2244	polysaccharide biosynthetic process
MKI63_RS08560	COG2081	HI0933 family
MKI63_RS08580	COG2814	Major facilitator Superfamily
MKI63_RS08585	COG1242	4 iron, 4 sulfur cluster binding
MKI63_RS08590	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MKI63_RS08600	COG2267	carboxylic ester hydrolase activity
MKI63_RS08630	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MKI63_RS08630	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MKI63_RS08650	COG3266	domain, Protein
MKI63_RS08650	COG5632	N-Acetylmuramoyl-L-alanine amidase
MKI63_RS08650	COG4193	domain, Protein
MKI63_RS08680	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MKI63_RS08705	COG0656	L-ascorbic acid biosynthetic process
MKI63_RS08725	COG1506	peptidase
MKI63_RS08730	COG2816	NAD+ diphosphatase activity
MKI63_RS08975	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
MKI63_RS09005	COG1131	(ABC) transporter
MKI63_RS09010	COG0537	adenosine 5'-monophosphoramidase activity
MKI63_RS09040	COG0420	3'-5' exonuclease activity
MKI63_RS09065	COG2197	response regulator
MKI63_RS09070	COG2203	Gaf domain
MKI63_RS09070	COG4585	Histidine kinase
MKI63_RS09075	COG0564	pseudouridine synthase activity
MKI63_RS09105	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MKI63_RS09110	COG1126	abc transporter atp-binding protein
MKI63_RS09115	COG0765	amino acid transport
MKI63_RS09295	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MKI63_RS09300	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MKI63_RS09310	COG4129	membrane
MKI63_RS09335	COG1988	membrane-bound metal-dependent
MKI63_RS09345	COG1134	teichoic acid transport
MKI63_RS09345	COG1388	LysM domain
MKI63_RS09390	COG1388	LysM domain
MKI63_RS09390	COG5632	N-Acetylmuramoyl-L-alanine amidase
MKI63_RS09600	COG1484	DNA-dependent DNA replication
MKI63_RS09710	COG4974	Belongs to the 'phage' integrase family
MKI63_RS09715	COG0535	radical SAM domain protein
MKI63_RS09720	COG1607	acyl-coa hydrolase
MKI63_RS09725	COG2309	aminopeptidase activity
MKI63_RS09745	COG1295	ribonuclease BN
MKI63_RS09860	COG4851	CamS sex pheromone cAM373 precursor
MKI63_RS09880	COG4496	protein, YerC YecD
MKI63_RS09915	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MKI63_RS09925	COG0077	Prephenate dehydratase
MKI63_RS09945	COG1335	isochorismatase
MKI63_RS09960	COG1012	belongs to the aldehyde dehydrogenase family
MKI63_RS10015	COG1131	(ABC) transporter
MKI63_RS10030	COG1725	Transcriptional regulator
MKI63_RS10080	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MKI63_RS10125	COG5484	DNA packaging
MKI63_RS10125	COG3728	DNA packaging
MKI63_RS10210	COG0582	viral genome integration into host DNA
MKI63_RS10275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MKI63_RS10280	COG1621	beta-fructofuranosidase activity
MKI63_RS10285	COG1609	Transcriptional regulator
MKI63_RS10290	COG0004	ammonium transporteR
MKI63_RS10295	COG0425	Belongs to the sulfur carrier protein TusA family
MKI63_RS10300	COG2391	methyltransferase activity
MKI63_RS10310	COG0488	(ABC) transporter
MKI63_RS10320	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MKI63_RS10330	COG0456	acetyltransferase
MKI63_RS10335	COG1214	PFAM Peptidase M22, glycoprotease
MKI63_RS10340	COG0802	atpase or kinase
MKI63_RS10355	COG0028	Belongs to the TPP enzyme family
MKI63_RS10425	COG2183	response to ionizing radiation
MKI63_RS10430	COG1191	sigma factor activity
MKI63_RS10440	COG1366	Belongs to the anti-sigma-factor antagonist family
MKI63_RS10445	COG2208	phosphoserine phosphatase activity
MKI63_RS10475	COG3428	Bacterial PH domain
MKI63_RS10505	COG2205	protein histidine kinase activity
MKI63_RS10510	COG0745	RESPONSE REGULATOR receiver
MKI63_RS10530	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MKI63_RS10540	COG0772	Belongs to the SEDS family
MKI63_RS10555	COG1937	Protein conserved in bacteria
MKI63_RS10565	COG1418	mRNA catabolic process
MKI63_RS10600	COG0629	single-stranded DNA binding
MKI63_RS10675	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MKI63_RS10700	COG0009	L-threonylcarbamoyladenylate synthase
MKI63_RS10705	COG2890	protein-(glutamine-N5) methyltransferase activity
MKI63_RS10725	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MKI63_RS10765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MKI63_RS10810	COG0813	purine-nucleoside phosphorylase activity
MKI63_RS10815	COG0783	Belongs to the Dps family
MKI63_RS10835	COG1482	cell wall glycoprotein biosynthetic process
MKI63_RS10840	COG0702	epimerase
MKI63_RS10845	COG0640	Transcriptional regulator
MKI63_RS10875	COG0561	phosphatase activity
MKI63_RS10880	COG1119	ATPase activity
MKI63_RS10895	COG3711	transcriptional antiterminator
MKI63_RS10925	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MKI63_RS10995	COG0489	protein tyrosine kinase activity
MKI63_RS11000	COG2814	Major facilitator Superfamily
MKI63_RS11015	COG1272	protein, Hemolysin III
MKI63_RS11025	COG1988	membrane-bound metal-dependent
MKI63_RS11035	COG3314	Sporulation integral membrane protein YlbJ
MKI63_RS11040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MKI63_RS11045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MKI63_RS11050	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
MKI63_RS11060	COG3457	Alanine racemase
MKI63_RS11065	COG4264	IucA IucC family
MKI63_RS11070	COG2814	Major facilitator Superfamily
MKI63_RS11095	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MKI63_RS11105	COG2130	NADP-dependent
MKI63_RS11170	COG0656	L-ascorbic acid biosynthetic process
MKI63_RS11175	COG0789	Transcriptional regulator
MKI63_RS11185	COG5492	domain, Protein
MKI63_RS11205	COG3527	Alpha-acetolactate decarboxylase
MKI63_RS11210	COG0028	Belongs to the TPP enzyme family
MKI63_RS11330	COG0201	protein transport
MKI63_RS11445	COG2252	PERMEase
MKI63_RS11490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MKI63_RS11550	COG1763	Mo-molybdopterin cofactor biosynthetic process
MKI63_RS11570	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MKI63_RS11575	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
MKI63_RS11580	COG4149	molybdate abc transporter
MKI63_RS11585	COG0725	ABC transporter, periplasmic molybdate-binding protein
MKI63_RS11600	COG1268	BioY protein
MKI63_RS11615	COG1960	acyl-CoA dehydrogenase activity
MKI63_RS11620	COG4413	Urea transporter
MKI63_RS11680	COG3942	CHAP domain
MKI63_RS11690	COG1757	Na H antiporter
MKI63_RS11705	COG3942	CHAP domain
MKI63_RS11770	COG1113	amino acid transport
MKI63_RS11790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MKI63_RS11795	COG0385	Bile acid
MKI63_RS11805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MKI63_RS11805	COG1263	PTS System
MKI63_RS11810	COG1737	Transcriptional regulator
MKI63_RS11830	COG1028	Short-chain dehydrogenase reductase Sdr
MKI63_RS11835	COG1473	amidohydrolase
MKI63_RS11850	COG0583	DNA-binding transcription factor activity
MKI63_RS11875	COG2258	MOSC domain
MKI63_RS11895	COG1668	transmembrane transport
MKI63_RS11905	COG3152	Membrane
MKI63_RS11915	COG0786	glutamate:sodium symporter activity
MKI63_RS11925	COG0598	Magnesium transport protein CorA
MKI63_RS11940	COG0657	acetylesterase activity
MKI63_RS11950	COG2814	Major facilitator Superfamily
MKI63_RS11955	COG1566	PFAM secretion protein HlyD family protein
MKI63_RS11965	COG2814	Major facilitator Superfamily
MKI63_RS12025	COG1620	l-lactate permease
MKI63_RS12045	COG0604	alcohol dehydrogenase
MKI63_RS12070	COG1511	domain protein
MKI63_RS12085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MKI63_RS12085	COG1263	PTS System
MKI63_RS12100	COG3871	stress protein (general stress protein 26)
MKI63_RS12140	COG0789	Transcriptional regulator
MKI63_RS12160	COG2181	nitrate reductase activity
MKI63_RS12170	COG1140	nitrate reductase beta subunit
MKI63_RS12175	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
MKI63_RS12185	COG2146	nitrite reductase [NAD(P)H] activity
MKI63_RS12190	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MKI63_RS12200	COG0454	-acetyltransferase
MKI63_RS12205	COG2116	formate transmembrane transporter activity
MKI63_RS12220	COG3443	Belongs to the bacterial solute-binding protein 9 family
MKI63_RS12220	COG0803	Belongs to the bacterial solute-binding protein 9 family
MKI63_RS12260	COG1126	abc transporter atp-binding protein
MKI63_RS12265	COG0765	amino acid transport
MKI63_RS12270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MKI63_RS12275	COG2814	Major facilitator Superfamily
MKI63_RS12290	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MKI63_RS12330	COG0156	8-amino-7-oxononanoate synthase activity
MKI63_RS12340	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MKI63_RS12345	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
MKI63_RS12355	COG1132	(ABC) transporter
MKI63_RS12360	COG1132	(ABC) transporter
MKI63_RS12360	COG2375	cellular response to nickel ion
MKI63_RS12375	COG1929	Belongs to the glycerate kinase type-1 family
MKI63_RS12385	COG2814	Major facilitator Superfamily
MKI63_RS12405	COG1113	amino acid transport
MKI63_RS12415	COG0531	amino acid
MKI63_RS12430	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MKI63_RS12440	COG1174	glycine betaine transport
MKI63_RS12450	COG1174	glycine betaine transport
MKI63_RS12470	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
MKI63_RS12475	COG0531	amino acid
MKI63_RS12480	COG2272	Belongs to the type-B carboxylesterase lipase family
MKI63_RS12485	COG2814	Major facilitator Superfamily
MKI63_RS12490	COG0390	transport system, permease component
MKI63_RS12495	COG4619	ABC transporter
MKI63_RS12500	COG1363	Peptidase, m42
MKI63_RS12515	COG4808	Protein conserved in bacteria
MKI63_RS12520	COG0069	glutamate synthase activity
MKI63_RS12575	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MKI63_RS12580	COG1028	Short-chain dehydrogenase reductase Sdr
MKI63_RS12585	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
MKI63_RS12590	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MKI63_RS12680	COG0494	nUDIX hydrolase
MKI63_RS12720	COG1846	Transcriptional regulator
MKI63_RS12750	COG1070	Carbohydrate kinase
MKI63_RS12755	COG1802	Transcriptional regulator
MKI63_RS12760	COG0789	Transcriptional regulator
MKI63_RS12765	COG2357	RelA SpoT domain protein
MKI63_RS12770	COG4876	unkown
MKI63_RS12780	COG2271	Major facilitator Superfamily
MKI63_RS12785	COG0586	Pfam SNARE associated Golgi protein
MKI63_RS12795	COG1131	(ABC) transporter
MKI63_RS12810	COG3949	Membrane
MKI63_RS12815	COG0400	carboxylic ester hydrolase activity
MKI63_RS12820	COG0346	lactoylglutathione lyase activity
MKI63_RS12825	COG1846	Transcriptional regulator
MKI63_RS12835	COG2514	catechol 2,3-dioxygenase activity
MKI63_RS12850	COG0561	phosphatase activity
MKI63_RS12855	COG1131	(ABC) transporter
MKI63_RS12865	COG3764	Sortase (surface protein transpeptidase)
MKI63_RS12885	COG1760	l-serine dehydratase
MKI63_RS12890	COG1760	l-serine dehydratase
MKI63_RS12905	COG0697	spore germination
MKI63_RS12910	COG0657	acetylesterase activity
MKI63_RS12930	COG0028	Belongs to the TPP enzyme family
MKI63_RS12945	COG0583	DNA-binding transcription factor activity
MKI63_RS12955	COG3942	CHAP domain
MKI63_RS12965	COG3425	synthase
MKI63_RS12970	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MKI63_RS12995	COG2409	Drug exporters of the RND superfamily
MKI63_RS13050	COG0436	Aminotransferase
MKI63_RS13080	COG3942	CHAP domain
MKI63_RS13085	COG2755	lipolytic protein G-D-S-L family
MKI63_RS13085	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MKI63_RS13200	COG0456	acetyltransferase
MKI63_RS13245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MKI63_RS13255	COG1279	arginine transmembrane transporter activity
MKI63_RS13275	COG3173	Aminoglycoside phosphotransferase
MKI63_RS13335	COG2801	Transposase and inactivated derivatives
MKI63_RS13340	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MKI63_RS13425	COG2378	regulation of single-species biofilm formation
MKI63_RS13435	COG0456	acetyltransferase
MKI63_RS13445	COG2226	methyltransferase
MKI63_RS13495	COG1192	Involved in chromosome partitioning
MKI63_RS13515	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MKI63_RS13530	COG4115	mRNA cleavage
MKI63_RS13565	COG0456	acetyltransferase
MKI63_RS13610	COG3409	Peptidoglycan-binding domain 1 protein
MKI63_RS13625	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MKI63_RS13790	COG0456	acetyltransferase
MKI63_RS13860	COG3001	Fructosamine kinase
MKI63_RS13865	COG0167	dihydroorotate dehydrogenase activity
MKI63_RS13920	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MKI63_RS13925	COG3527	Alpha-acetolactate decarboxylase
MKI63_RS13935	COG0531	amino acid
MKI63_RS13965	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MKI63_RS13985	COG1012	belongs to the aldehyde dehydrogenase family
MKI63_RS13995	COG1510	regulation of RNA biosynthetic process
MKI63_RS14000	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MKI63_RS14025	COG2851	Citrate transporter
MKI63_RS14040	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MKI63_RS14050	COG0386	Belongs to the glutathione peroxidase family
MKI63_RS14070	COG1136	(ABC) transporter
MKI63_RS14075	COG2205	protein histidine kinase activity
MKI63_RS14080	COG0745	RESPONSE REGULATOR receiver
MKI63_RS14090	COG1785	Belongs to the alkaline phosphatase family
MKI63_RS14100	COG1846	Transcriptional regulator
MKI63_RS14145	COG1438	arginine binding
MKI63_RS14165	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MKI63_RS14165	COG3711	transcriptional antiterminator
MKI63_RS14170	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MKI63_RS14170	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MKI63_RS14170	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MKI63_RS14175	COG1482	cell wall glycoprotein biosynthetic process
MKI63_RS14185	COG1705	Flagellar rod assembly protein muramidase FlgJ
MKI63_RS14185	COG3942	CHAP domain
MKI63_RS14190	COG1535	isochorismatase
MKI63_RS14190	COG3433	isochorismatase activity
MKI63_RS14205	COG0438	transferase activity, transferring glycosyl groups
MKI63_RS14220	COG1073	alpha beta
MKI63_RS14240	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MKI63_RS14260	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MKI63_RS14345	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MKI63_RS14430	COG0471	metal ion transport
MKI63_RS14435	COG2962	Rard protein
MKI63_RS14445	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
MKI63_RS14460	COG1136	(ABC) transporter
MKI63_RS14465	COG0577	efflux transmembrane transporter activity
MKI63_RS14475	COG1278	Cold shock
MKI63_RS14495	COG1475	DNA binding
MKI63_RS14565	COG0604	alcohol dehydrogenase
MKI63_RS14585	COG3682	Transcriptional regulator
MKI63_RS14635	COG0577	efflux transmembrane transporter activity
MKI63_RS14635	COG1136	(ABC) transporter