locus-tag	class	description
JYH18_RS00015	COG2501	S4 domain
JYH18_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
JYH18_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
JYH18_RS00060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
JYH18_RS00070	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
JYH18_RS00080	COG0305	Participates in initiation and elongation during chromosome replication
JYH18_RS00110	COG4863	YycH protein
JYH18_RS00120	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
JYH18_RS00125	COG0737	Belongs to the 5'-nucleotidase family
JYH18_RS00150	COG0584	glycerophosphoryl diester phosphodiesterase
JYH18_RS00155	COG2030	dehydratase
JYH18_RS00360	COG2801	Transposase and inactivated derivatives
JYH18_RS00380	COG0456	acetyltransferase
JYH18_RS00395	COG0730	response to heat
JYH18_RS00400	COG1937	Protein conserved in bacteria
JYH18_RS00405	COG2210	Belongs to the sulfur carrier protein TusA family
JYH18_RS00410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JYH18_RS00440	COG0655	NAD(P)H dehydrogenase (quinone) activity
JYH18_RS00455	COG0583	DNA-binding transcription factor activity
JYH18_RS00475	COG0823	Involved in the tonB-independent uptake of proteins
JYH18_RS00515	COG1473	amidohydrolase
JYH18_RS00525	COG1283	sodium-dependent phosphate transmembrane transporter activity
JYH18_RS00530	COG4716	Myosin-crossreactive antigen
JYH18_RS00540	COG1620	l-lactate permease
JYH18_RS00555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JYH18_RS00560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JYH18_RS00565	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JYH18_RS00575	COG2423	ornithine cyclodeaminase activity
JYH18_RS00580	COG4264	IucA IucC family
JYH18_RS00585	COG2814	Major facilitator Superfamily
JYH18_RS00590	COG4264	IucA IucC family
JYH18_RS00595	COG4264	IucA IucC family
JYH18_RS00605	COG0019	diaminopimelate decarboxylase activity
JYH18_RS00610	COG1475	DNA binding
JYH18_RS00635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JYH18_RS00640	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JYH18_RS00645	COG0438	transferase activity, transferring glycosyl groups
JYH18_RS00675	COG0813	purine-nucleoside phosphorylase activity
JYH18_RS00680	COG2814	Major facilitator Superfamily
JYH18_RS00700	COG3639	organic phosphonate transmembrane transporter activity
JYH18_RS00720	COG0737	Belongs to the 5'-nucleotidase family
JYH18_RS00745	COG1454	alcohol dehydrogenase
JYH18_RS00745	COG1012	belongs to the aldehyde dehydrogenase family
JYH18_RS00770	COG1086	Polysaccharide biosynthesis protein
JYH18_RS00780	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
JYH18_RS00810	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JYH18_RS00820	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
JYH18_RS00825	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
JYH18_RS00835	COG2832	Protein of unknown function (DUF454)
JYH18_RS00870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JYH18_RS00875	COG1960	acyl-CoA dehydrogenase activity
JYH18_RS00880	COG5609	conserved protein (DUF2294)
JYH18_RS00930	COG1114	Component of the transport system for branched-chain amino acids
JYH18_RS00935	COG1335	isochorismatase
JYH18_RS00940	COG3961	Belongs to the TPP enzyme family
JYH18_RS00965	COG1737	Transcriptional regulator
JYH18_RS00990	COG1136	(ABC) transporter
JYH18_RS00995	COG0577	efflux transmembrane transporter activity
JYH18_RS00995	COG1136	(ABC) transporter
JYH18_RS01015	COG1131	(ABC) transporter
JYH18_RS01030	COG0601	transmembrane transport
JYH18_RS01035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JYH18_RS01045	COG0405	Gamma-glutamyltransferase
JYH18_RS01065	COG3842	ATPase activity
JYH18_RS01075	COG1175	transmembrane transport
JYH18_RS01080	COG3833	ABC-type maltose transport systems, permease component
JYH18_RS01085	COG0673	inositol 2-dehydrogenase activity
JYH18_RS01090	COG0673	inositol 2-dehydrogenase activity
JYH18_RS01100	COG1755	Isoprenylcysteine carboxyl methyltransferase
JYH18_RS01155	COG0183	Belongs to the thiolase family
JYH18_RS01165	COG1960	acyl-CoA dehydrogenase activity
JYH18_RS01170	COG0318	PFAM AMP-dependent synthetase and ligase
JYH18_RS01185	COG0747	negative chemotaxis
JYH18_RS01190	COG3189	MarR family transcriptional regulator
JYH18_RS01215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JYH18_RS01215	COG1263	PTS System
JYH18_RS01215	COG2190	(PTS) system
JYH18_RS01220	COG1957	nucleoside hydrolase
JYH18_RS01240	COG3414	Phosphotransferase system galactitol-specific IIB component
JYH18_RS01245	COG3775	system Galactitol-specific IIC component
JYH18_RS01250	COG1063	alcohol dehydrogenase
JYH18_RS01260	COG1063	alcohol dehydrogenase
JYH18_RS01270	COG1063	alcohol dehydrogenase
JYH18_RS01275	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JYH18_RS01280	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JYH18_RS01290	COG1063	alcohol dehydrogenase
JYH18_RS01295	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JYH18_RS01330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JYH18_RS01335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JYH18_RS01335	COG1263	PTS System
JYH18_RS01335	COG2190	(PTS) system
JYH18_RS01340	COG2723	6-phospho-beta-galactosidase activity
JYH18_RS01345	COG2226	methyltransferase
JYH18_RS01400	COG1131	(ABC) transporter
JYH18_RS01420	COG3942	CHAP domain
JYH18_RS01420	COG1388	LysM domain
JYH18_RS01545	COG1114	Component of the transport system for branched-chain amino acids
JYH18_RS01550	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
JYH18_RS01555	COG0577	efflux transmembrane transporter activity
JYH18_RS01580	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JYH18_RS01585	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JYH18_RS01610	COG3314	Sporulation integral membrane protein YlbJ
JYH18_RS01635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JYH18_RS01665	COG3037	sugar-specific permease SgaT UlaA
JYH18_RS01675	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JYH18_RS01680	COG3711	transcriptional antiterminator
JYH18_RS01700	COG2271	Major facilitator Superfamily
JYH18_RS01705	COG0346	lactoylglutathione lyase activity
JYH18_RS01710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JYH18_RS01715	COG0431	NADPH-dependent FMN reductase
JYH18_RS01725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JYH18_RS01740	COG0672	)-iron permease
JYH18_RS01745	COG0805	protein transport
JYH18_RS01750	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JYH18_RS01760	COG1476	TRANSCRIPTIONal
JYH18_RS01770	COG1131	(ABC) transporter
JYH18_RS01800	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
JYH18_RS01800	COG0646	methionine synthase
JYH18_RS01805	COG0626	cystathionine gamma-synthase activity
JYH18_RS01815	COG1475	DNA binding
JYH18_RS01820	COG0668	transmembrane transport
JYH18_RS01825	COG4481	Protein conserved in bacteria
JYH18_RS01830	COG0012	GTP binding
JYH18_RS01930	COG1823	symporter activity
JYH18_RS01960	COG2233	PERMEase
JYH18_RS02020	COG1683	Conserved Protein
JYH18_RS02030	COG3759	membrane
JYH18_RS02165	COG0523	cobalamin synthesis protein
JYH18_RS02190	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JYH18_RS02200	COG5609	conserved protein (DUF2294)
JYH18_RS02215	COG1647	Serine aminopeptidase, S33
JYH18_RS02225	COG0733	neurotransmitter:sodium symporter activity
JYH18_RS02230	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JYH18_RS02235	COG0626	cystathionine gamma-synthase activity
JYH18_RS02245	COG2011	ABC-type metal ion transport system permease component
JYH18_RS02250	COG1464	Belongs to the NlpA lipoprotein family
JYH18_RS02285	COG0583	DNA-binding transcription factor activity
JYH18_RS02290	COG0067	glutamate synthase
JYH18_RS02290	COG0069	glutamate synthase activity
JYH18_RS02290	COG0070	glutamate synthase
JYH18_RS02295	COG0493	'glutamate synthase
JYH18_RS02305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JYH18_RS02305	COG1263	PTS System
JYH18_RS02310	COG0366	Alpha amylase catalytic
JYH18_RS02315	COG2188	Transcriptional regulator
JYH18_RS02335	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
JYH18_RS02365	COG1982	Orn Lys Arg decarboxylase major
JYH18_RS02375	COG3870	Protein conserved in bacteria
JYH18_RS02380	COG0470	DNA polymerase III
JYH18_RS02385	COG1774	PSP1 C-terminal conserved region
JYH18_RS02395	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
JYH18_RS02405	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
JYH18_RS02415	COG0084	hydrolase, TatD family'
JYH18_RS02420	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
JYH18_RS02430	COG4466	Protein conserved in bacteria
JYH18_RS02440	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JYH18_RS02445	COG0251	oxidation-reduction process
JYH18_RS02485	COG2244	polysaccharide biosynthetic process
JYH18_RS02490	COG3956	TIGRFAM MazG family protein
JYH18_RS02495	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
JYH18_RS02505	COG1098	S1 RNA binding domain
JYH18_RS02520	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JYH18_RS02545	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
JYH18_RS02640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JYH18_RS02655	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JYH18_RS02665	COG3880	PFAM UvrB UvrC protein
JYH18_RS02680	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
JYH18_RS02685	COG4956	integral membrane protein (PIN domain superfamily)
JYH18_RS02705	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
JYH18_RS02760	COG2813	Specifically methylates the guanine in position
JYH18_RS02800	COG1473	amidohydrolase
JYH18_RS02830	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
JYH18_RS02835	COG1428	Deoxynucleoside kinase
JYH18_RS02840	COG1428	Deoxynucleoside kinase
JYH18_RS02850	COG0561	phosphatase activity
JYH18_RS02890	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
JYH18_RS02995	COG0095	Lipoate-protein ligase
JYH18_RS03000	COG0083	homoserine kinase activity
JYH18_RS03020	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JYH18_RS03105	COG0667	Aldo Keto reductase
JYH18_RS03110	COG0655	NAD(P)H dehydrogenase (quinone) activity
JYH18_RS03120	COG1078	dGTPase activity
JYH18_RS03155	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JYH18_RS03160	COG4139	cobalamin transport
JYH18_RS03210	COG4974	Belongs to the 'phage' integrase family
JYH18_RS03255	COG0803	Belongs to the bacterial solute-binding protein 9 family
JYH18_RS03260	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JYH18_RS03265	COG1121	(ABC) transporter
JYH18_RS03270	COG1321	iron dependent repressor
JYH18_RS03280	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
JYH18_RS03290	COG1682	transport, permease protein
JYH18_RS03295	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JYH18_RS03305	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
JYH18_RS03310	COG1686	Belongs to the peptidase S11 family
JYH18_RS03315	COG1132	(ABC) transporter
JYH18_RS03320	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JYH18_RS03330	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JYH18_RS03335	COG1120	ATPase activity
JYH18_RS03340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JYH18_RS03345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JYH18_RS03350	COG2376	Dihydroxyacetone kinase
JYH18_RS03360	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
JYH18_RS03370	COG3949	Membrane
JYH18_RS03390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JYH18_RS03405	COG1136	(ABC) transporter
JYH18_RS03410	COG0577	efflux transmembrane transporter activity
JYH18_RS03415	COG1392	Phosphate transport regulator
JYH18_RS03420	COG0306	phosphate transporter
JYH18_RS03425	COG1388	LysM domain
JYH18_RS03425	COG3942	CHAP domain
JYH18_RS03435	COG4977	sequence-specific DNA binding
JYH18_RS03435	COG1917	Cupin 2, conserved barrel domain protein
JYH18_RS03465	COG0583	DNA-binding transcription factor activity
JYH18_RS03470	COG2814	Major facilitator Superfamily
JYH18_RS03475	COG2839	Protein conserved in bacteria
JYH18_RS03505	COG1611	Belongs to the LOG family
JYH18_RS03525	COG4988	ABC transporter
JYH18_RS03530	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
JYH18_RS03545	COG4989	oxidoreductase activity
JYH18_RS03555	COG0471	metal ion transport
JYH18_RS03560	COG0415	Belongs to the DNA photolyase family
JYH18_RS03590	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
JYH18_RS03595	COG1349	DNA-binding transcription factor activity
JYH18_RS03600	COG1105	Belongs to the carbohydrate kinase PfkB family
JYH18_RS03605	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JYH18_RS03605	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JYH18_RS03605	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JYH18_RS03610	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
JYH18_RS03615	COG1253	flavin adenine dinucleotide binding
JYH18_RS03620	COG0656	L-ascorbic acid biosynthetic process
JYH18_RS03625	COG0463	Glycosyl transferase, family 2
JYH18_RS03660	COG0720	synthase
JYH18_RS03670	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
JYH18_RS03670	COG0512	Glutamine amidotransferase of anthranilate synthase
JYH18_RS03675	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JYH18_RS03705	COG0488	(ABC) transporter
JYH18_RS03710	COG0514	ATP-dependent DNA helicase (RecQ)
JYH18_RS03715	COG1125	glycine betaine transport
JYH18_RS03715	COG0517	IMP dehydrogenase activity
JYH18_RS03720	COG1174	glycine betaine transport
JYH18_RS03745	COG3104	oligopeptide transport
JYH18_RS03765	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JYH18_RS03770	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JYH18_RS03780	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JYH18_RS03785	COG4605	iron ion homeostasis
JYH18_RS03790	COG4604	ABC transporter, ATP-binding protein
JYH18_RS03795	COG4607	ABC-type enterochelin transport system periplasmic component
JYH18_RS03850	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JYH18_RS03855	COG1739	Uncharacterized protein family UPF0029
JYH18_RS03865	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
JYH18_RS03870	COG1040	competence protein
JYH18_RS03900	COG3942	CHAP domain
JYH18_RS03900	COG1388	LysM domain
JYH18_RS03955	COG0391	Required for morphogenesis under gluconeogenic growth conditions
JYH18_RS04015	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JYH18_RS04020	COG1647	Serine aminopeptidase, S33
JYH18_RS04025	COG0557	exoribonuclease II activity
JYH18_RS04085	COG1278	Cold shock
JYH18_RS04125	COG0406	alpha-ribazole phosphatase activity
JYH18_RS04130	COG1279	arginine transmembrane transporter activity
JYH18_RS04155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JYH18_RS04160	COG1393	Belongs to the ArsC family
JYH18_RS04170	COG3878	Protein conserved in bacteria
JYH18_RS04175	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
JYH18_RS04190	COG2011	ABC-type metal ion transport system permease component
JYH18_RS04195	COG1464	Belongs to the NlpA lipoprotein family
JYH18_RS04210	COG0396	ATPase activity
JYH18_RS04215	COG0719	Fe-S assembly protein
JYH18_RS04225	COG0822	iron-sulfur transferase activity
JYH18_RS04245	COG1253	flavin adenine dinucleotide binding
JYH18_RS04255	COG1801	Protein of unknown function DUF72
JYH18_RS04260	COG0730	response to heat
JYH18_RS04275	COG4470	Protein conserved in bacteria
JYH18_RS04285	COG2445	Protein of unknown function DUF86
JYH18_RS04315	COG1696	Membrane protein involved in D-alanine export
JYH18_RS04325	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
JYH18_RS04330	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
JYH18_RS04335	COG4837	Protein of unknown function (DUF1462)
JYH18_RS04340	COG1252	NADH dehydrogenase
JYH18_RS04350	COG0316	Belongs to the HesB IscA family
JYH18_RS04360	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
JYH18_RS04365	COG2056	Na+-H+ antiporter family
JYH18_RS04370	COG2050	protein possibly involved in aromatic compounds catabolism
JYH18_RS04425	COG1098	S1 RNA binding domain
JYH18_RS04430	COG1902	pentaerythritol trinitrate reductase activity
JYH18_RS04445	COG0584	glycerophosphoryl diester phosphodiesterase
JYH18_RS04465	COG0398	Pfam SNARE associated Golgi protein
JYH18_RS04505	COG0561	phosphatase activity
JYH18_RS04530	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JYH18_RS04545	COG1881	PFAM PEBP family protein
JYH18_RS04575	COG0601	transmembrane transport
JYH18_RS04580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JYH18_RS04585	COG0444	Belongs to the ABC transporter superfamily
JYH18_RS04590	COG4608	Belongs to the ABC transporter superfamily
JYH18_RS04595	COG4166	transmembrane transport
JYH18_RS04600	COG0747	negative chemotaxis
JYH18_RS04605	COG0444	Belongs to the ABC transporter superfamily
JYH18_RS04610	COG4608	Belongs to the ABC transporter superfamily
JYH18_RS04615	COG0601	transmembrane transport
JYH18_RS04620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JYH18_RS04645	COG1164	Oligoendopeptidase f
JYH18_RS04655	COG2346	COG2346, Truncated hemoglobins
JYH18_RS04670	COG2357	RelA SpoT domain protein
JYH18_RS04680	COG0564	pseudouridine synthase activity
JYH18_RS04685	COG2239	Acts as a magnesium transporter
JYH18_RS04690	COG0569	domain protein
JYH18_RS04690	COG0475	glutathione-regulated potassium exporter activity
JYH18_RS04700	COG0628	permease
JYH18_RS04705	COG1115	amino acid carrier protein
JYH18_RS04745	COG0861	Integral membrane protein TerC family
JYH18_RS04755	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JYH18_RS04760	COG0737	Belongs to the 5'-nucleotidase family
JYH18_RS04775	COG4903	ComK protein
JYH18_RS04790	COG4873	Protein conserved in bacteria
JYH18_RS04850	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
JYH18_RS04860	COG2314	TM2 domain
JYH18_RS04865	COG0456	acetyltransferase
JYH18_RS04870	COG1575	Belongs to the MenA family. Type 1 subfamily
JYH18_RS04875	COG1169	isochorismate synthase
JYH18_RS04885	COG2267	carboxylic ester hydrolase activity
JYH18_RS04910	COG0436	Aminotransferase
JYH18_RS04915	COG3594	Acyltransferase
JYH18_RS04945	COG1316	TRANSCRIPTIONal
JYH18_RS04990	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
JYH18_RS05005	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JYH18_RS05035	COG0138	bifunctional purine biosynthesis protein purh
JYH18_RS05045	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
JYH18_RS05050	COG4172	Belongs to the ABC transporter superfamily
JYH18_RS05055	COG4721	ABC-type cobalt transport system, permease component
JYH18_RS05070	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
JYH18_RS05090	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
JYH18_RS05095	COG1271	oxidase subunit
JYH18_RS05100	COG1294	oxidase, subunit
JYH18_RS05105	COG0569	domain protein
JYH18_RS05170	COG1176	ABC-type spermidine putrescine transport system, permease component I
JYH18_RS05175	COG1177	transmembrane transport
JYH18_RS05180	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
JYH18_RS05205	COG0483	inositol monophosphate 1-phosphatase activity
JYH18_RS05215	COG1217	gtp-binding protein TYPA
JYH18_RS05225	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
JYH18_RS05235	COG0772	Belongs to the SEDS family
JYH18_RS05265	COG3679	Belongs to the UPF0342 family
JYH18_RS05285	COG0742	ribosomal rna small subunit methyltransferase
JYH18_RS05340	COG4509	Sortase family
JYH18_RS05355	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JYH18_RS05385	COG1796	DNA polymerase
JYH18_RS05385	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JYH18_RS05410	COG2009	succinate dehydrogenase
JYH18_RS05415	COG1053	succinate dehydrogenase
JYH18_RS05420	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JYH18_RS05525	COG1288	antiporter activity
JYH18_RS05560	COG1011	Hydrolase
JYH18_RS05585	COG4839	cell division protein FtsL
JYH18_RS05590	COG0768	penicillin binding
JYH18_RS05605	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
JYH18_RS05625	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
JYH18_RS05635	COG0762	integral membrane protein
JYH18_RS05640	COG2302	S4 RNA-binding domain
JYH18_RS05645	COG3599	regulation of cell shape
JYH18_RS05655	COG2514	catechol 2,3-dioxygenase activity
JYH18_RS05670	COG0564	pseudouridine synthase activity
JYH18_RS05680	COG2233	PERMEase
JYH18_RS05725	COG1293	RNA-binding protein homologous to eukaryotic snRNP
JYH18_RS05740	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
JYH18_RS05745	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
JYH18_RS05755	COG2314	TM2 domain
JYH18_RS05770	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JYH18_RS05770	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JYH18_RS05780	COG0631	protein serine/threonine phosphatase activity
JYH18_RS05795	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JYH18_RS05810	COG1302	Protein conserved in bacteria
JYH18_RS05855	COG1196	nuclear chromosome segregation
JYH18_RS05860	COG0552	protein localization to endoplasmic reticulum
JYH18_RS05870	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
JYH18_RS05930	COG0758	DNA mediated transformation
JYH18_RS06025	COG0195	Participates in both transcription termination and antitermination
JYH18_RS06030	COG2740	Nucleic-acid-binding protein implicated in transcription termination
JYH18_RS06055	COG0196	riboflavin kinase activity
JYH18_RS06080	COG2188	Transcriptional regulator
JYH18_RS06085	COG0612	Peptidase, M16
JYH18_RS06090	COG0612	Peptidase, M16
JYH18_RS06095	COG0300	oxidoreductase activity
JYH18_RS06115	COG1546	Belongs to the CinA family
JYH18_RS06115	COG1058	Belongs to the CinA family
JYH18_RS06135	COG1692	metallophosphoesterase
JYH18_RS06140	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
JYH18_RS06140	COG0674	pyruvate-flavodoxin oxidoreductase activity
JYH18_RS06145	COG1013	pyruvate-flavodoxin oxidoreductase activity
JYH18_RS06180	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
JYH18_RS06185	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
JYH18_RS06210	COG1923	regulation of RNA biosynthetic process
JYH18_RS06220	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JYH18_RS06225	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
JYH18_RS06230	COG0789	Transcriptional regulator
JYH18_RS06320	COG1131	(ABC) transporter
JYH18_RS06335	COG2197	response regulator
JYH18_RS06345	COG1525	nuclease
JYH18_RS06360	COG0527	aspartate kinase activity
JYH18_RS06365	COG0460	homoserine dehydrogenase
JYH18_RS06370	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
JYH18_RS06395	COG0833	amino acid
JYH18_RS06420	COG2340	Cysteine-rich secretory protein family
JYH18_RS06455	COG4846	Membrane protein involved in cytochrome C biogenesis
JYH18_RS06475	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JYH18_RS06485	COG0824	Thioesterase
JYH18_RS06510	COG1115	amino acid carrier protein
JYH18_RS06525	COG0628	permease
JYH18_RS06550	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JYH18_RS06560	COG1363	Peptidase, m42
JYH18_RS06565	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JYH18_RS06570	COG0512	Glutamine amidotransferase of anthranilate synthase
JYH18_RS06660	COG0704	Plays a role in the regulation of phosphate uptake
JYH18_RS06670	COG0581	inorganic phosphate transmembrane transporter activity
JYH18_RS06675	COG0573	inorganic phosphate transmembrane transporter activity
JYH18_RS06695	COG0488	(ABC) transporter
JYH18_RS06700	COG0527	aspartate kinase activity
JYH18_RS06705	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
JYH18_RS06780	COG4548	von Willebrand factor, type A
JYH18_RS06785	COG0714	Associated with various cellular activities
JYH18_RS06830	COG0671	phosphoesterase, PA-phosphatase related
JYH18_RS06910	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
JYH18_RS06930	COG0531	amino acid
JYH18_RS06945	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JYH18_RS06950	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
JYH18_RS06965	COG0116	Belongs to the methyltransferase superfamily
JYH18_RS07000	COG4499	WXG100 protein secretion system (Wss), protein YukC
JYH18_RS07000	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JYH18_RS07010	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
JYH18_RS07015	COG3935	DnaD domain protein
JYH18_RS07040	COG0438	transferase activity, transferring glycosyl groups
JYH18_RS07045	COG1694	Mazg nucleotide pyrophosphohydrolase
JYH18_RS07050	COG2738	Putative neutral zinc metallopeptidase
JYH18_RS07055	COG4347	Protein of unknown function (DUF1405)
JYH18_RS07095	COG0142	geranyltranstransferase activity
JYH18_RS07140	COG0492	ferredoxin-NADP+ reductase activity
JYH18_RS07155	COG0514	ATP-dependent DNA helicase (RecQ)
JYH18_RS07165	COG1141	Ferredoxin
JYH18_RS07200	COG5002	protein histidine kinase activity
JYH18_RS07205	COG0745	RESPONSE REGULATOR receiver
JYH18_RS07210	COG1187	pseudouridine synthase activity
JYH18_RS07235	COG0735	belongs to the Fur family
JYH18_RS07240	COG0494	nUDIX hydrolase
JYH18_RS07245	COG0667	Aldo Keto reductase
JYH18_RS07255	COG4221	oxidoreductase activity
JYH18_RS07270	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
JYH18_RS07280	COG0366	Alpha amylase catalytic
JYH18_RS07285	COG1609	Transcriptional regulator
JYH18_RS07305	COG2195	Cleaves the N-terminal amino acid of tripeptides
JYH18_RS07315	COG4129	membrane
JYH18_RS07325	COG0508	dehydrogenase complex catalyzes the overall conversion of
JYH18_RS07330	COG0022	dehydrogenase e1 component
JYH18_RS07335	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
JYH18_RS07340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JYH18_RS07345	COG0497	DNA recombination
JYH18_RS07375	COG1302	Protein conserved in bacteria
JYH18_RS07380	COG0439	Biotin carboxylase
JYH18_RS07385	COG0511	ligase activity, forming carbon-carbon bonds
JYH18_RS07395	COG0006	proline dipeptidase activity
JYH18_RS07410	COG0095	Lipoate-protein ligase
JYH18_RS07415	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JYH18_RS07460	COG4537	Required for transformation and DNA binding
JYH18_RS07465	COG1459	type II secretion system
JYH18_RS07470	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JYH18_RS07475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JYH18_RS07480	COG0011	TIGRFAM Protein of
JYH18_RS07485	COG1940	carbohydrate kinase activity
JYH18_RS07490	COG4483	Protein conserved in bacteria
JYH18_RS07500	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
JYH18_RS07510	COG0768	penicillin binding
JYH18_RS07525	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JYH18_RS07530	COG1121	(ABC) transporter
JYH18_RS07540	COG0513	Belongs to the DEAD box helicase family
JYH18_RS07550	COG2384	SAM-dependent methyltransferase
JYH18_RS07570	COG0517	IMP dehydrogenase activity
JYH18_RS07590	COG0295	cytidine deaminase activity
JYH18_RS07605	COG1702	phosphate starvation-inducible protein PhoH
JYH18_RS07620	COG1030	water channel activity
JYH18_RS07630	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JYH18_RS07635	COG1385	rRNA (uridine-N3-)-methyltransferase activity
JYH18_RS07665	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JYH18_RS07680	COG1466	dna polymerase III delta subunit
JYH18_RS07685	COG0658	competence protein
JYH18_RS07685	COG2333	competence protein COMEC
JYH18_RS07690	COG2131	deaminase
JYH18_RS07695	COG2183	response to ionizing radiation
JYH18_RS07700	COG2226	methyltransferase
JYH18_RS07705	COG0799	negative regulation of ribosome biogenesis
JYH18_RS07710	COG1713	HD superfamily hydrolase involved in NAD metabolism
JYH18_RS07720	COG1534	Rna-binding protein
JYH18_RS07730	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
JYH18_RS07735	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
JYH18_RS07755	COG3177	Filamentation induced by cAMP protein fic
JYH18_RS07760	COG1914	H( )-stimulated, divalent metal cation uptake system
JYH18_RS07770	COG0439	Biotin carboxylase
JYH18_RS07775	COG0511	ligase activity, forming carbon-carbon bonds
JYH18_RS07780	COG1984	allophanate hydrolase subunit 2
JYH18_RS07785	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
JYH18_RS07800	COG0826	peptidase U32
JYH18_RS07805	COG0826	peptidase U32
JYH18_RS07835	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JYH18_RS07850	COG1104	cysteine desulfurase activity
JYH18_RS07855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JYH18_RS07865	COG3237	CsbD-like
JYH18_RS07870	COG1959	2 iron, 2 sulfur cluster binding
JYH18_RS07875	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
JYH18_RS07880	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
JYH18_RS07925	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
JYH18_RS07925	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
JYH18_RS07930	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JYH18_RS07930	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JYH18_RS07935	COG1862	Preprotein translocase
JYH18_RS07975	COG2868	ribosomal protein
JYH18_RS08020	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
JYH18_RS08025	COG0285	dihydrofolate synthase activity
JYH18_RS08035	COG2818	Glycosylase
JYH18_RS08070	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JYH18_RS08105	COG4112	unkown
JYH18_RS08140	COG1484	DNA-dependent DNA replication
JYH18_RS08170	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JYH18_RS08170	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JYH18_RS08180	COG5002	protein histidine kinase activity
JYH18_RS08185	COG0745	RESPONSE REGULATOR receiver
JYH18_RS08195	COG0372	Belongs to the citrate synthase family
JYH18_RS08200	COG1113	amino acid transport
JYH18_RS08225	COG0281	malic enzyme
JYH18_RS08235	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
JYH18_RS08240	COG4109	DRTGG domain
JYH18_RS08280	COG0827	DNA restriction-modification system
JYH18_RS08290	COG0730	response to heat
JYH18_RS08300	COG1104	cysteine desulfurase activity
JYH18_RS08315	COG1956	GAF domain-containing protein
JYH18_RS08325	COG0584	glycerophosphoryl diester phosphodiesterase
JYH18_RS08330	COG1764	response to oxidative stress
JYH18_RS08335	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
JYH18_RS08340	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JYH18_RS08355	COG1263	PTS System
JYH18_RS08355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JYH18_RS08360	COG0204	Acyl-transferase
JYH18_RS08365	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JYH18_RS08400	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JYH18_RS08405	COG0454	-acetyltransferase
JYH18_RS08425	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
JYH18_RS08425	COG1605	Chorismate mutase
JYH18_RS08450	COG1674	ftsk spoiiie
JYH18_RS08455	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JYH18_RS08465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JYH18_RS08470	COG1363	Peptidase, m42
JYH18_RS08480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JYH18_RS08490	COG0510	thiamine kinase activity
JYH18_RS08510	COG1187	pseudouridine synthase activity
JYH18_RS08515	COG2244	polysaccharide biosynthetic process
JYH18_RS08520	COG2081	HI0933 family
JYH18_RS08540	COG2814	Major facilitator Superfamily
JYH18_RS08545	COG1242	4 iron, 4 sulfur cluster binding
JYH18_RS08550	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
JYH18_RS08560	COG2267	carboxylic ester hydrolase activity
JYH18_RS08590	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JYH18_RS08590	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JYH18_RS08610	COG3266	domain, Protein
JYH18_RS08610	COG4193	domain, Protein
JYH18_RS08610	COG5632	N-Acetylmuramoyl-L-alanine amidase
JYH18_RS08640	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JYH18_RS08660	COG0656	L-ascorbic acid biosynthetic process
JYH18_RS08680	COG1506	peptidase
JYH18_RS08685	COG2816	NAD+ diphosphatase activity
JYH18_RS08845	COG1131	(ABC) transporter
JYH18_RS08945	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
JYH18_RS08975	COG1131	(ABC) transporter
JYH18_RS08980	COG0537	adenosine 5'-monophosphoramidase activity
JYH18_RS09010	COG0420	3'-5' exonuclease activity
JYH18_RS09035	COG2197	response regulator
JYH18_RS09040	COG2203	Gaf domain
JYH18_RS09040	COG4585	Histidine kinase
JYH18_RS09045	COG0564	pseudouridine synthase activity
JYH18_RS09075	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
JYH18_RS09080	COG1126	abc transporter atp-binding protein
JYH18_RS09085	COG0765	amino acid transport
JYH18_RS09250	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JYH18_RS09255	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
JYH18_RS09265	COG4129	membrane
JYH18_RS09290	COG1988	membrane-bound metal-dependent
JYH18_RS09300	COG1134	teichoic acid transport
JYH18_RS09300	COG1388	LysM domain
JYH18_RS09330	COG0535	radical SAM domain protein
JYH18_RS09335	COG1607	acyl-coa hydrolase
JYH18_RS09340	COG2309	aminopeptidase activity
JYH18_RS09360	COG1295	ribonuclease BN
JYH18_RS09475	COG4851	CamS sex pheromone cAM373 precursor
JYH18_RS09485	COG0210	DNA helicase
JYH18_RS09495	COG4496	protein, YerC YecD
JYH18_RS09530	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
JYH18_RS09540	COG0077	Prephenate dehydratase
JYH18_RS09560	COG1335	isochorismatase
JYH18_RS09575	COG1012	belongs to the aldehyde dehydrogenase family
JYH18_RS09630	COG1131	(ABC) transporter
JYH18_RS09645	COG1725	Transcriptional regulator
JYH18_RS09705	COG1388	LysM domain
JYH18_RS09705	COG5632	N-Acetylmuramoyl-L-alanine amidase
JYH18_RS09755	COG0739	heme binding
JYH18_RS09810	COG4695	Portal protein
JYH18_RS10000	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
JYH18_RS10005	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JYH18_RS10010	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JYH18_RS10025	COG5484	DNA packaging
JYH18_RS10025	COG3728	DNA packaging
JYH18_RS10100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JYH18_RS10105	COG1621	beta-fructofuranosidase activity
JYH18_RS10110	COG1609	Transcriptional regulator
JYH18_RS10115	COG0004	ammonium transporteR
JYH18_RS10120	COG0425	Belongs to the sulfur carrier protein TusA family
JYH18_RS10125	COG2391	methyltransferase activity
JYH18_RS10135	COG0488	(ABC) transporter
JYH18_RS10145	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
JYH18_RS10155	COG0456	acetyltransferase
JYH18_RS10160	COG1214	PFAM Peptidase M22, glycoprotease
JYH18_RS10165	COG0802	atpase or kinase
JYH18_RS10180	COG0028	Belongs to the TPP enzyme family
JYH18_RS10250	COG2183	response to ionizing radiation
JYH18_RS10255	COG1191	sigma factor activity
JYH18_RS10265	COG1366	Belongs to the anti-sigma-factor antagonist family
JYH18_RS10270	COG2208	phosphoserine phosphatase activity
JYH18_RS10300	COG3428	Bacterial PH domain
JYH18_RS10330	COG2205	protein histidine kinase activity
JYH18_RS10335	COG0745	RESPONSE REGULATOR receiver
JYH18_RS10345	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JYH18_RS10355	COG0772	Belongs to the SEDS family
JYH18_RS10370	COG1937	Protein conserved in bacteria
JYH18_RS10380	COG1418	mRNA catabolic process
JYH18_RS10415	COG0629	single-stranded DNA binding
JYH18_RS10490	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
JYH18_RS10515	COG0009	L-threonylcarbamoyladenylate synthase
JYH18_RS10520	COG2890	protein-(glutamine-N5) methyltransferase activity
JYH18_RS10540	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
JYH18_RS10580	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JYH18_RS10625	COG0813	purine-nucleoside phosphorylase activity
JYH18_RS10630	COG0783	Belongs to the Dps family
JYH18_RS10650	COG1482	cell wall glycoprotein biosynthetic process
JYH18_RS10655	COG0702	epimerase
JYH18_RS10660	COG0640	Transcriptional regulator
JYH18_RS10685	COG0561	phosphatase activity
JYH18_RS10690	COG1119	ATPase activity
JYH18_RS10705	COG3711	transcriptional antiterminator
JYH18_RS10735	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
JYH18_RS10795	COG0489	protein tyrosine kinase activity
JYH18_RS10800	COG2814	Major facilitator Superfamily
JYH18_RS10815	COG1272	protein, Hemolysin III
JYH18_RS10825	COG1988	membrane-bound metal-dependent
JYH18_RS10835	COG3314	Sporulation integral membrane protein YlbJ
JYH18_RS10840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JYH18_RS10845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JYH18_RS10850	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
JYH18_RS10860	COG3457	Alanine racemase
JYH18_RS10865	COG4264	IucA IucC family
JYH18_RS10870	COG2814	Major facilitator Superfamily
JYH18_RS10895	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JYH18_RS10905	COG2130	NADP-dependent
JYH18_RS10975	COG0656	L-ascorbic acid biosynthetic process
JYH18_RS10980	COG0789	Transcriptional regulator
JYH18_RS10990	COG5492	domain, Protein
JYH18_RS11000	COG3527	Alpha-acetolactate decarboxylase
JYH18_RS11005	COG0028	Belongs to the TPP enzyme family
JYH18_RS11080	COG0201	protein transport
JYH18_RS11195	COG2252	PERMEase
JYH18_RS11240	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JYH18_RS11300	COG1763	Mo-molybdopterin cofactor biosynthetic process
JYH18_RS11320	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
JYH18_RS11325	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
JYH18_RS11330	COG4149	molybdate abc transporter
JYH18_RS11335	COG0725	ABC transporter, periplasmic molybdate-binding protein
JYH18_RS11350	COG1268	BioY protein
JYH18_RS11365	COG1960	acyl-CoA dehydrogenase activity
JYH18_RS11370	COG4413	Urea transporter
JYH18_RS11440	COG1757	Na H antiporter
JYH18_RS11455	COG3942	CHAP domain
JYH18_RS11525	COG1113	amino acid transport
JYH18_RS11545	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JYH18_RS11550	COG0385	Bile acid
JYH18_RS11560	COG1263	PTS System
JYH18_RS11560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JYH18_RS11565	COG1737	Transcriptional regulator
JYH18_RS11585	COG1028	Short-chain dehydrogenase reductase Sdr
JYH18_RS11590	COG1473	amidohydrolase
JYH18_RS11605	COG0583	DNA-binding transcription factor activity
JYH18_RS11625	COG2258	MOSC domain
JYH18_RS11645	COG1668	transmembrane transport
JYH18_RS11650	COG4152	abc transporter atp-binding protein
JYH18_RS11655	COG3152	Membrane
JYH18_RS11665	COG0786	glutamate:sodium symporter activity
JYH18_RS11675	COG0598	Magnesium transport protein CorA
JYH18_RS11690	COG0657	acetylesterase activity
JYH18_RS11700	COG2814	Major facilitator Superfamily
JYH18_RS11705	COG1566	PFAM secretion protein HlyD family protein
JYH18_RS11715	COG2814	Major facilitator Superfamily
JYH18_RS11775	COG1620	l-lactate permease
JYH18_RS11795	COG0604	alcohol dehydrogenase
JYH18_RS11825	COG1511	domain protein
JYH18_RS11840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JYH18_RS11840	COG1263	PTS System
JYH18_RS11855	COG3871	stress protein (general stress protein 26)
JYH18_RS11895	COG0789	Transcriptional regulator
JYH18_RS11915	COG2181	nitrate reductase activity
JYH18_RS11925	COG1140	nitrate reductase beta subunit
JYH18_RS11930	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
JYH18_RS11940	COG2146	nitrite reductase [NAD(P)H] activity
JYH18_RS11945	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JYH18_RS11955	COG0454	-acetyltransferase
JYH18_RS11960	COG2116	formate transmembrane transporter activity
JYH18_RS11975	COG0803	Belongs to the bacterial solute-binding protein 9 family
JYH18_RS11975	COG3443	Belongs to the bacterial solute-binding protein 9 family
JYH18_RS12010	COG1126	abc transporter atp-binding protein
JYH18_RS12015	COG0765	amino acid transport
JYH18_RS12020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JYH18_RS12025	COG2814	Major facilitator Superfamily
JYH18_RS12040	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
JYH18_RS12080	COG0156	8-amino-7-oxononanoate synthase activity
JYH18_RS12090	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
JYH18_RS12095	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
JYH18_RS12105	COG1132	(ABC) transporter
JYH18_RS12110	COG2375	cellular response to nickel ion
JYH18_RS12110	COG1132	(ABC) transporter
JYH18_RS12125	COG1929	Belongs to the glycerate kinase type-1 family
JYH18_RS12135	COG2814	Major facilitator Superfamily
JYH18_RS12155	COG1113	amino acid transport
JYH18_RS12165	COG0531	amino acid
JYH18_RS12180	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
JYH18_RS12190	COG1174	glycine betaine transport
JYH18_RS12200	COG1174	glycine betaine transport
JYH18_RS12220	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
JYH18_RS12225	COG0531	amino acid
JYH18_RS12230	COG2272	Belongs to the type-B carboxylesterase lipase family
JYH18_RS12235	COG2814	Major facilitator Superfamily
JYH18_RS12240	COG0390	transport system, permease component
JYH18_RS12245	COG4619	ABC transporter
JYH18_RS12250	COG1363	Peptidase, m42
JYH18_RS12265	COG4808	Protein conserved in bacteria
JYH18_RS12270	COG0069	glutamate synthase activity
JYH18_RS12285	COG1124	(ABC) transporter
JYH18_RS12290	COG0444	Belongs to the ABC transporter superfamily
JYH18_RS12295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JYH18_RS12330	COG1028	Short-chain dehydrogenase reductase Sdr
JYH18_RS12335	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
JYH18_RS12340	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
JYH18_RS12410	COG0494	nUDIX hydrolase
JYH18_RS12450	COG1846	Transcriptional regulator
JYH18_RS12480	COG1070	Carbohydrate kinase
JYH18_RS12485	COG1802	Transcriptional regulator
JYH18_RS12490	COG0789	Transcriptional regulator
JYH18_RS12495	COG2357	RelA SpoT domain protein
JYH18_RS12500	COG4876	unkown
JYH18_RS12510	COG2271	Major facilitator Superfamily
JYH18_RS12515	COG0586	Pfam SNARE associated Golgi protein
JYH18_RS12520	COG1131	(ABC) transporter
JYH18_RS12535	COG3949	Membrane
JYH18_RS12540	COG0400	carboxylic ester hydrolase activity
JYH18_RS12545	COG0346	lactoylglutathione lyase activity
JYH18_RS12550	COG1846	Transcriptional regulator
JYH18_RS12575	COG0561	phosphatase activity
JYH18_RS12580	COG1131	(ABC) transporter
JYH18_RS12590	COG3764	Sortase (surface protein transpeptidase)
JYH18_RS12610	COG1760	l-serine dehydratase
JYH18_RS12615	COG1760	l-serine dehydratase
JYH18_RS12630	COG0697	spore germination
JYH18_RS12635	COG0657	acetylesterase activity
JYH18_RS12655	COG0028	Belongs to the TPP enzyme family
JYH18_RS12670	COG0583	DNA-binding transcription factor activity
JYH18_RS12680	COG3942	CHAP domain
JYH18_RS12690	COG3425	synthase
JYH18_RS12695	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JYH18_RS12720	COG2409	Drug exporters of the RND superfamily
JYH18_RS12765	COG0436	Aminotransferase
JYH18_RS12795	COG3942	CHAP domain
JYH18_RS12800	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
JYH18_RS12800	COG2755	lipolytic protein G-D-S-L family
JYH18_RS12905	COG3001	Fructosamine kinase
JYH18_RS12910	COG0167	dihydroorotate dehydrogenase activity
JYH18_RS12960	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
JYH18_RS12965	COG3527	Alpha-acetolactate decarboxylase
JYH18_RS12975	COG0531	amino acid
JYH18_RS13005	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JYH18_RS13025	COG1012	belongs to the aldehyde dehydrogenase family
JYH18_RS13035	COG1510	regulation of RNA biosynthetic process
JYH18_RS13045	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JYH18_RS13070	COG2851	Citrate transporter
JYH18_RS13080	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
JYH18_RS13090	COG0386	Belongs to the glutathione peroxidase family
JYH18_RS13110	COG1136	(ABC) transporter
JYH18_RS13115	COG2205	protein histidine kinase activity
JYH18_RS13120	COG0745	RESPONSE REGULATOR receiver
JYH18_RS13130	COG1785	Belongs to the alkaline phosphatase family
JYH18_RS13140	COG1846	Transcriptional regulator
JYH18_RS13185	COG1438	arginine binding
JYH18_RS13205	COG3711	transcriptional antiterminator
JYH18_RS13205	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JYH18_RS13210	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JYH18_RS13210	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JYH18_RS13210	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JYH18_RS13215	COG1482	cell wall glycoprotein biosynthetic process
JYH18_RS13225	COG1705	Flagellar rod assembly protein muramidase FlgJ
JYH18_RS13225	COG3942	CHAP domain
JYH18_RS13230	COG1535	isochorismatase
JYH18_RS13230	COG3433	isochorismatase activity
JYH18_RS13245	COG0438	transferase activity, transferring glycosyl groups
JYH18_RS13260	COG1073	alpha beta
JYH18_RS13280	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JYH18_RS13300	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JYH18_RS13355	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
JYH18_RS13390	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JYH18_RS13470	COG0471	metal ion transport
JYH18_RS13475	COG2962	Rard protein
JYH18_RS13485	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
JYH18_RS13500	COG1136	(ABC) transporter
JYH18_RS13505	COG0577	efflux transmembrane transporter activity
JYH18_RS13515	COG1278	Cold shock
JYH18_RS13535	COG1475	DNA binding
JYH18_RS13615	COG3682	Transcriptional regulator
JYH18_RS13650	COG0577	efflux transmembrane transporter activity
JYH18_RS13650	COG1136	(ABC) transporter