locus-tag	class	description
LR49_RS00025	COG1923	regulation of RNA biosynthetic process
LR49_RS00040	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
LR49_RS00045	COG0789	Transcriptional regulator
LR49_RS00190	COG1131	(ABC) transporter
LR49_RS00205	COG2197	response regulator
LR49_RS00215	COG1525	nuclease
LR49_RS00235	COG0527	aspartate kinase activity
LR49_RS00240	COG0460	homoserine dehydrogenase
LR49_RS00245	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LR49_RS00270	COG0833	amino acid
LR49_RS00300	COG2340	Cysteine-rich secretory protein family
LR49_RS00335	COG4846	Membrane protein involved in cytochrome C biogenesis
LR49_RS00355	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LR49_RS00370	COG0824	Thioesterase
LR49_RS00410	COG1115	amino acid carrier protein
LR49_RS00430	COG0628	permease
LR49_RS00435	COG0392	lysyltransferase activity
LR49_RS00435	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LR49_RS00455	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LR49_RS00465	COG1363	Peptidase, m42
LR49_RS00470	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LR49_RS00475	COG0512	Glutamine amidotransferase of anthranilate synthase
LR49_RS00515	COG0561	phosphatase activity
LR49_RS00560	COG0704	Plays a role in the regulation of phosphate uptake
LR49_RS00570	COG0581	inorganic phosphate transmembrane transporter activity
LR49_RS00575	COG0573	inorganic phosphate transmembrane transporter activity
LR49_RS00595	COG0488	(ABC) transporter
LR49_RS00600	COG0527	aspartate kinase activity
LR49_RS00605	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LR49_RS00685	COG4548	von Willebrand factor, type A
LR49_RS00690	COG0714	Associated with various cellular activities
LR49_RS00740	COG0671	phosphoesterase, PA-phosphatase related
LR49_RS00800	COG1413	lyase activity
LR49_RS00815	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LR49_RS00840	COG0531	amino acid
LR49_RS00855	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LR49_RS00860	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
LR49_RS00875	COG0116	Belongs to the methyltransferase superfamily
LR49_RS00915	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LR49_RS00915	COG4499	WXG100 protein secretion system (Wss), protein YukC
LR49_RS00925	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LR49_RS00930	COG3935	DnaD domain protein
LR49_RS00960	COG0438	transferase activity, transferring glycosyl groups
LR49_RS00965	COG1694	Mazg nucleotide pyrophosphohydrolase
LR49_RS00970	COG2738	Putative neutral zinc metallopeptidase
LR49_RS00975	COG4347	Protein of unknown function (DUF1405)
LR49_RS01015	COG0142	geranyltranstransferase activity
LR49_RS01080	COG0492	ferredoxin-NADP+ reductase activity
LR49_RS01095	COG0514	ATP-dependent DNA helicase (RecQ)
LR49_RS01105	COG1141	Ferredoxin
LR49_RS01150	COG5002	protein histidine kinase activity
LR49_RS01155	COG0745	RESPONSE REGULATOR receiver
LR49_RS01160	COG1187	pseudouridine synthase activity
LR49_RS01185	COG0735	belongs to the Fur family
LR49_RS01190	COG0494	nUDIX hydrolase
LR49_RS01195	COG0667	Aldo Keto reductase
LR49_RS01205	COG4221	oxidoreductase activity
LR49_RS01220	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LR49_RS01230	COG0366	Alpha amylase catalytic
LR49_RS01255	COG2195	Cleaves the N-terminal amino acid of tripeptides
LR49_RS01265	COG4129	membrane
LR49_RS01275	COG0508	dehydrogenase complex catalyzes the overall conversion of
LR49_RS01280	COG0022	dehydrogenase e1 component
LR49_RS01285	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LR49_RS01290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LR49_RS01295	COG0497	DNA recombination
LR49_RS01325	COG1302	Protein conserved in bacteria
LR49_RS01330	COG0439	Biotin carboxylase
LR49_RS01335	COG0511	ligase activity, forming carbon-carbon bonds
LR49_RS01345	COG0006	proline dipeptidase activity
LR49_RS01360	COG0095	Lipoate-protein ligase
LR49_RS01365	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LR49_RS01410	COG4537	Required for transformation and DNA binding
LR49_RS01415	COG1459	type II secretion system
LR49_RS01420	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LR49_RS01425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LR49_RS01430	COG0011	TIGRFAM Protein of
LR49_RS01435	COG1940	carbohydrate kinase activity
LR49_RS01440	COG4483	Protein conserved in bacteria
LR49_RS01450	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LR49_RS01460	COG0768	penicillin binding
LR49_RS01475	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LR49_RS01480	COG1121	(ABC) transporter
LR49_RS01490	COG0513	Belongs to the DEAD box helicase family
LR49_RS01500	COG2384	SAM-dependent methyltransferase
LR49_RS01520	COG0517	IMP dehydrogenase activity
LR49_RS01540	COG0295	cytidine deaminase activity
LR49_RS01555	COG1702	phosphate starvation-inducible protein PhoH
LR49_RS01570	COG1030	water channel activity
LR49_RS01580	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LR49_RS01585	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LR49_RS01615	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LR49_RS01635	COG1466	dna polymerase III delta subunit
LR49_RS01640	COG2333	competence protein COMEC
LR49_RS01640	COG0658	competence protein
LR49_RS01645	COG2131	deaminase
LR49_RS01655	COG2226	methyltransferase
LR49_RS01660	COG0799	negative regulation of ribosome biogenesis
LR49_RS01665	COG1713	HD superfamily hydrolase involved in NAD metabolism
LR49_RS01675	COG1534	Rna-binding protein
LR49_RS01685	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LR49_RS01690	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
LR49_RS01710	COG3177	Filamentation induced by cAMP protein fic
LR49_RS01715	COG1914	H( )-stimulated, divalent metal cation uptake system
LR49_RS01725	COG0439	Biotin carboxylase
LR49_RS01730	COG0511	ligase activity, forming carbon-carbon bonds
LR49_RS01735	COG1984	allophanate hydrolase subunit 2
LR49_RS01740	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LR49_RS01755	COG0826	peptidase U32
LR49_RS01760	COG0826	peptidase U32
LR49_RS01790	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LR49_RS01805	COG1104	cysteine desulfurase activity
LR49_RS01810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LR49_RS01825	COG1959	2 iron, 2 sulfur cluster binding
LR49_RS01830	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LR49_RS01835	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LR49_RS01880	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LR49_RS01880	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LR49_RS01885	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LR49_RS01885	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LR49_RS01890	COG1862	Preprotein translocase
LR49_RS01930	COG2868	ribosomal protein
LR49_RS01975	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LR49_RS02020	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LR49_RS02030	COG0285	dihydrofolate synthase activity
LR49_RS02040	COG2818	Glycosylase
LR49_RS02075	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LR49_RS02110	COG4112	unkown
LR49_RS02135	COG0833	amino acid
LR49_RS02150	COG1484	DNA-dependent DNA replication
LR49_RS02180	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LR49_RS02180	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LR49_RS02190	COG5002	protein histidine kinase activity
LR49_RS02195	COG0745	RESPONSE REGULATOR receiver
LR49_RS02210	COG0372	Belongs to the citrate synthase family
LR49_RS02215	COG1113	amino acid transport
LR49_RS02245	COG0281	malic enzyme
LR49_RS02255	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LR49_RS02265	COG4109	DRTGG domain
LR49_RS02315	COG0827	DNA restriction-modification system
LR49_RS02335	COG1104	cysteine desulfurase activity
LR49_RS02350	COG1956	GAF domain-containing protein
LR49_RS02370	COG0584	glycerophosphoryl diester phosphodiesterase
LR49_RS02375	COG1764	response to oxidative stress
LR49_RS02380	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LR49_RS02385	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LR49_RS02400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LR49_RS02400	COG1263	PTS System
LR49_RS02405	COG0204	Acyl-transferase
LR49_RS02410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LR49_RS02445	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LR49_RS02450	COG0454	-acetyltransferase
LR49_RS02470	COG1605	Chorismate mutase
LR49_RS02470	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
LR49_RS02505	COG1674	ftsk spoiiie
LR49_RS02510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LR49_RS02520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LR49_RS02525	COG1363	Peptidase, m42
LR49_RS02535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LR49_RS02550	COG0510	thiamine kinase activity
LR49_RS02575	COG1187	pseudouridine synthase activity
LR49_RS02580	COG2244	polysaccharide biosynthetic process
LR49_RS02585	COG2081	HI0933 family
LR49_RS02605	COG2814	Major facilitator Superfamily
LR49_RS02610	COG1242	4 iron, 4 sulfur cluster binding
LR49_RS02615	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
LR49_RS02630	COG2267	carboxylic ester hydrolase activity
LR49_RS02665	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LR49_RS02665	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LR49_RS02690	COG5632	N-Acetylmuramoyl-L-alanine amidase
LR49_RS02690	COG3266	domain, Protein
LR49_RS02690	COG4193	domain, Protein
LR49_RS02725	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LR49_RS02750	COG0656	L-ascorbic acid biosynthetic process
LR49_RS02775	COG1506	peptidase
LR49_RS02960	COG1131	(ABC) transporter
LR49_RS03080	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
LR49_RS03110	COG1131	(ABC) transporter
LR49_RS03115	COG0537	adenosine 5'-monophosphoramidase activity
LR49_RS03150	COG0420	3'-5' exonuclease activity
LR49_RS03180	COG2197	response regulator
LR49_RS03185	COG2203	Gaf domain
LR49_RS03185	COG4585	Histidine kinase
LR49_RS03190	COG0564	pseudouridine synthase activity
LR49_RS03230	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LR49_RS03235	COG1126	abc transporter atp-binding protein
LR49_RS03240	COG0765	amino acid transport
LR49_RS03410	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LR49_RS03415	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LR49_RS03425	COG4129	membrane
LR49_RS03450	COG1988	membrane-bound metal-dependent
LR49_RS03465	COG1388	LysM domain
LR49_RS03465	COG1134	teichoic acid transport
LR49_RS03495	COG0535	radical SAM domain protein
LR49_RS03500	COG1607	acyl-coa hydrolase
LR49_RS03505	COG2309	aminopeptidase activity
LR49_RS03525	COG1295	ribonuclease BN
LR49_RS03530	COG2197	response regulator
LR49_RS03650	COG4851	CamS sex pheromone cAM373 precursor
LR49_RS03660	COG0210	DNA helicase
LR49_RS03670	COG4496	protein, YerC YecD
LR49_RS03710	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LR49_RS03720	COG0077	Prephenate dehydratase
LR49_RS03730	COG0471	metal ion transport
LR49_RS03740	COG1335	isochorismatase
LR49_RS03755	COG1012	belongs to the aldehyde dehydrogenase family
LR49_RS03810	COG1131	(ABC) transporter
LR49_RS03825	COG1725	Transcriptional regulator
LR49_RS03890	COG1388	LysM domain
LR49_RS03890	COG0860	N-Acetylmuramoyl-L-alanine amidase
LR49_RS03910	COG5632	N-Acetylmuramoyl-L-alanine amidase
LR49_RS03910	COG1388	LysM domain
LR49_RS04010	COG0740	serine-type endopeptidase activity
LR49_RS04220	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LR49_RS04225	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LR49_RS04240	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LR49_RS04260	COG3728	DNA packaging
LR49_RS04260	COG5484	DNA packaging
LR49_RS04300	COG5484	DNA packaging
LR49_RS04300	COG3728	DNA packaging
LR49_RS04385	COG0582	viral genome integration into host DNA
LR49_RS04450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LR49_RS04455	COG1621	beta-fructofuranosidase activity
LR49_RS04460	COG1609	Transcriptional regulator
LR49_RS04465	COG0004	ammonium transporteR
LR49_RS04470	COG0425	Belongs to the sulfur carrier protein TusA family
LR49_RS04475	COG2391	methyltransferase activity
LR49_RS04485	COG0488	(ABC) transporter
LR49_RS04495	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LR49_RS04505	COG0456	acetyltransferase
LR49_RS04510	COG1214	PFAM Peptidase M22, glycoprotease
LR49_RS04515	COG0802	atpase or kinase
LR49_RS04530	COG0028	Belongs to the TPP enzyme family
LR49_RS04605	COG2183	response to ionizing radiation
LR49_RS04610	COG1191	sigma factor activity
LR49_RS04620	COG1366	Belongs to the anti-sigma-factor antagonist family
LR49_RS04625	COG2208	phosphoserine phosphatase activity
LR49_RS04660	COG3428	Bacterial PH domain
LR49_RS04690	COG2205	protein histidine kinase activity
LR49_RS04695	COG0745	RESPONSE REGULATOR receiver
LR49_RS04705	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LR49_RS04715	COG0772	Belongs to the SEDS family
LR49_RS04730	COG1937	Protein conserved in bacteria
LR49_RS04740	COG1418	mRNA catabolic process
LR49_RS04790	COG0629	single-stranded DNA binding
LR49_RS04865	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LR49_RS04890	COG0009	L-threonylcarbamoyladenylate synthase
LR49_RS04895	COG2890	protein-(glutamine-N5) methyltransferase activity
LR49_RS04920	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LR49_RS04960	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LR49_RS05010	COG0813	purine-nucleoside phosphorylase activity
LR49_RS05015	COG0783	Belongs to the Dps family
LR49_RS05035	COG1482	cell wall glycoprotein biosynthetic process
LR49_RS05040	COG0702	epimerase
LR49_RS05045	COG0640	Transcriptional regulator
LR49_RS05080	COG0561	phosphatase activity
LR49_RS05085	COG1119	ATPase activity
LR49_RS05100	COG3711	transcriptional antiterminator
LR49_RS05130	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
LR49_RS05205	COG0489	protein tyrosine kinase activity
LR49_RS05210	COG2814	Major facilitator Superfamily
LR49_RS05225	COG1272	protein, Hemolysin III
LR49_RS05235	COG1988	membrane-bound metal-dependent
LR49_RS05245	COG3314	Sporulation integral membrane protein YlbJ
LR49_RS05250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LR49_RS05255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LR49_RS05260	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
LR49_RS05270	COG3457	Alanine racemase
LR49_RS05275	COG4264	IucA IucC family
LR49_RS05280	COG2814	Major facilitator Superfamily
LR49_RS05310	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LR49_RS05320	COG2130	NADP-dependent
LR49_RS05365	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LR49_RS05390	COG0656	L-ascorbic acid biosynthetic process
LR49_RS05395	COG0789	Transcriptional regulator
LR49_RS05405	COG5492	domain, Protein
LR49_RS05425	COG3527	Alpha-acetolactate decarboxylase
LR49_RS05430	COG0028	Belongs to the TPP enzyme family
LR49_RS05450	COG0542	response to heat
LR49_RS05535	COG0201	protein transport
LR49_RS05650	COG2252	PERMEase
LR49_RS05695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LR49_RS05770	COG1763	Mo-molybdopterin cofactor biosynthetic process
LR49_RS05790	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LR49_RS05795	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
LR49_RS05800	COG4149	molybdate abc transporter
LR49_RS05805	COG0725	ABC transporter, periplasmic molybdate-binding protein
LR49_RS05820	COG1268	BioY protein
LR49_RS05835	COG1960	acyl-CoA dehydrogenase activity
LR49_RS05840	COG4413	Urea transporter
LR49_RS05905	COG3942	CHAP domain
LR49_RS05915	COG1757	Na H antiporter
LR49_RS05930	COG3942	CHAP domain
LR49_RS06005	COG1113	amino acid transport
LR49_RS06025	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LR49_RS06030	COG0385	Bile acid
LR49_RS06040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LR49_RS06040	COG1263	PTS System
LR49_RS06045	COG1737	Transcriptional regulator
LR49_RS06065	COG1028	Short-chain dehydrogenase reductase Sdr
LR49_RS06070	COG1473	amidohydrolase
LR49_RS06085	COG0583	DNA-binding transcription factor activity
LR49_RS06110	COG2258	MOSC domain
LR49_RS06130	COG1668	transmembrane transport
LR49_RS06135	COG4152	abc transporter atp-binding protein
LR49_RS06140	COG3152	Membrane
LR49_RS06155	COG0786	glutamate:sodium symporter activity
LR49_RS06165	COG0598	Magnesium transport protein CorA
LR49_RS06180	COG0657	acetylesterase activity
LR49_RS06190	COG2814	Major facilitator Superfamily
LR49_RS06195	COG1566	PFAM secretion protein HlyD family protein
LR49_RS06205	COG2814	Major facilitator Superfamily
LR49_RS06275	COG1620	l-lactate permease
LR49_RS06295	COG0604	alcohol dehydrogenase
LR49_RS06300	COG0456	acetyltransferase
LR49_RS06325	COG1511	domain protein
LR49_RS06340	COG1263	PTS System
LR49_RS06340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LR49_RS06355	COG3871	stress protein (general stress protein 26)
LR49_RS06400	COG0789	Transcriptional regulator
LR49_RS06420	COG2181	nitrate reductase activity
LR49_RS06430	COG1140	nitrate reductase beta subunit
LR49_RS06435	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
LR49_RS06445	COG2146	nitrite reductase [NAD(P)H] activity
LR49_RS06450	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LR49_RS06460	COG0454	-acetyltransferase
LR49_RS06465	COG2116	formate transmembrane transporter activity
LR49_RS06480	COG3443	Belongs to the bacterial solute-binding protein 9 family
LR49_RS06480	COG0803	Belongs to the bacterial solute-binding protein 9 family
LR49_RS06520	COG1126	abc transporter atp-binding protein
LR49_RS06525	COG0765	amino acid transport
LR49_RS06530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LR49_RS06535	COG2814	Major facilitator Superfamily
LR49_RS06555	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
LR49_RS06605	COG0156	8-amino-7-oxononanoate synthase activity
LR49_RS06615	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LR49_RS06620	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LR49_RS06635	COG1132	(ABC) transporter
LR49_RS06640	COG1132	(ABC) transporter
LR49_RS06640	COG2375	cellular response to nickel ion
LR49_RS06660	COG1929	Belongs to the glycerate kinase type-1 family
LR49_RS06670	COG2814	Major facilitator Superfamily
LR49_RS06690	COG1113	amino acid transport
LR49_RS06705	COG0531	amino acid
LR49_RS06730	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LR49_RS06740	COG1174	glycine betaine transport
LR49_RS06750	COG1174	glycine betaine transport
LR49_RS06770	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
LR49_RS06780	COG0531	amino acid
LR49_RS06785	COG2272	Belongs to the type-B carboxylesterase lipase family
LR49_RS06790	COG2814	Major facilitator Superfamily
LR49_RS06795	COG0390	transport system, permease component
LR49_RS06800	COG4619	ABC transporter
LR49_RS06805	COG1363	Peptidase, m42
LR49_RS06825	COG4808	Protein conserved in bacteria
LR49_RS06830	COG0069	glutamate synthase activity
LR49_RS06845	COG1124	(ABC) transporter
LR49_RS06850	COG0444	Belongs to the ABC transporter superfamily
LR49_RS06855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LR49_RS06860	COG0601	transmembrane transport
LR49_RS06865	COG0747	negative chemotaxis
LR49_RS06895	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
LR49_RS06900	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LR49_RS06965	COG0494	nUDIX hydrolase
LR49_RS07010	COG1846	Transcriptional regulator
LR49_RS07015	COG1846	Transcriptional regulator
LR49_RS07050	COG1070	Carbohydrate kinase
LR49_RS07055	COG1802	Transcriptional regulator
LR49_RS07060	COG0789	Transcriptional regulator
LR49_RS07065	COG2357	RelA SpoT domain protein
LR49_RS07070	COG4876	unkown
LR49_RS07080	COG2271	Major facilitator Superfamily
LR49_RS07085	COG0586	Pfam SNARE associated Golgi protein
LR49_RS07095	COG2814	Major facilitator Superfamily
LR49_RS07115	COG1131	(ABC) transporter
LR49_RS07135	COG0400	carboxylic ester hydrolase activity
LR49_RS07140	COG0346	lactoylglutathione lyase activity
LR49_RS07145	COG1846	Transcriptional regulator
LR49_RS07155	COG2514	catechol 2,3-dioxygenase activity
LR49_RS07170	COG0561	phosphatase activity
LR49_RS07175	COG1131	(ABC) transporter
LR49_RS07185	COG3764	Sortase (surface protein transpeptidase)
LR49_RS07205	COG1760	l-serine dehydratase
LR49_RS07210	COG1760	l-serine dehydratase
LR49_RS07225	COG0697	spore germination
LR49_RS07230	COG0657	acetylesterase activity
LR49_RS07250	COG0028	Belongs to the TPP enzyme family
LR49_RS07265	COG0583	DNA-binding transcription factor activity
LR49_RS07275	COG3942	CHAP domain
LR49_RS07300	COG3425	synthase
LR49_RS07305	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LR49_RS07310	COG0542	response to heat
LR49_RS07330	COG2409	Drug exporters of the RND superfamily
LR49_RS07375	COG0436	Aminotransferase
LR49_RS07495	COG2826	transposase and inactivated derivatives, IS30 family
LR49_RS07515	COG3682	Transcriptional regulator
LR49_RS07560	COG1674	ftsk spoiiie
LR49_RS07565	COG0433	COG0433 Predicted ATPase
LR49_RS07585	COG2946	Replication initiation factor
LR49_RS07620	COG3001	Fructosamine kinase
LR49_RS07625	COG0167	dihydroorotate dehydrogenase activity
LR49_RS07675	COG3527	Alpha-acetolactate decarboxylase
LR49_RS07690	COG0531	amino acid
LR49_RS07720	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LR49_RS07740	COG1012	belongs to the aldehyde dehydrogenase family
LR49_RS07750	COG1510	regulation of RNA biosynthetic process
LR49_RS07755	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LR49_RS07780	COG2851	Citrate transporter
LR49_RS07795	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LR49_RS07805	COG0386	Belongs to the glutathione peroxidase family
LR49_RS07830	COG1136	(ABC) transporter
LR49_RS07835	COG2205	protein histidine kinase activity
LR49_RS07840	COG0745	RESPONSE REGULATOR receiver
LR49_RS07850	COG1785	Belongs to the alkaline phosphatase family
LR49_RS07860	COG1846	Transcriptional regulator
LR49_RS07905	COG1438	arginine binding
LR49_RS07925	COG3711	transcriptional antiterminator
LR49_RS07925	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LR49_RS07930	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LR49_RS07930	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LR49_RS07930	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LR49_RS07935	COG1482	cell wall glycoprotein biosynthetic process
LR49_RS07945	COG3942	CHAP domain
LR49_RS07945	COG1705	Flagellar rod assembly protein muramidase FlgJ
LR49_RS07950	COG3433	isochorismatase activity
LR49_RS07950	COG1535	isochorismatase
LR49_RS07965	COG0438	transferase activity, transferring glycosyl groups
LR49_RS07980	COG1073	alpha beta
LR49_RS08000	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LR49_RS08025	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LR49_RS08120	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LR49_RS08200	COG0471	metal ion transport
LR49_RS08205	COG2962	Rard protein
LR49_RS08215	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
LR49_RS08230	COG1136	(ABC) transporter
LR49_RS08235	COG0577	efflux transmembrane transporter activity
LR49_RS08260	COG1404	Belongs to the peptidase S8 family
LR49_RS08265	COG1278	Cold shock
LR49_RS08285	COG1475	DNA binding
LR49_RS08325	COG2501	S4 domain
LR49_RS08345	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LR49_RS08375	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LR49_RS08385	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
LR49_RS08395	COG0305	Participates in initiation and elongation during chromosome replication
LR49_RS08430	COG4863	YycH protein
LR49_RS08440	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LR49_RS08445	COG0737	Belongs to the 5'-nucleotidase family
LR49_RS08500	COG3425	synthase
LR49_RS08510	COG0584	glycerophosphoryl diester phosphodiesterase
LR49_RS08515	COG2030	dehydratase
LR49_RS08540	COG1940	carbohydrate kinase activity
LR49_RS08540	COG1846	Transcriptional regulator
LR49_RS08550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LR49_RS08555	COG2210	Belongs to the sulfur carrier protein TusA family
LR49_RS08560	COG1937	Protein conserved in bacteria
LR49_RS08565	COG0730	response to heat
LR49_RS08600	COG2003	Belongs to the UPF0758 family
LR49_RS08665	COG1401	restriction endodeoxyribonuclease activity
LR49_RS08690	COG0456	acetyltransferase
LR49_RS08725	COG0823	Involved in the tonB-independent uptake of proteins
LR49_RS08740	COG1473	amidohydrolase
LR49_RS08750	COG1283	sodium-dependent phosphate transmembrane transporter activity
LR49_RS08755	COG4716	Myosin-crossreactive antigen
LR49_RS08765	COG1620	l-lactate permease
LR49_RS08785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LR49_RS08790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LR49_RS08795	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LR49_RS08805	COG2423	ornithine cyclodeaminase activity
LR49_RS08810	COG4264	IucA IucC family
LR49_RS08815	COG2814	Major facilitator Superfamily
LR49_RS08820	COG4264	IucA IucC family
LR49_RS08825	COG4264	IucA IucC family
LR49_RS08835	COG0019	diaminopimelate decarboxylase activity
LR49_RS08840	COG1475	DNA binding
LR49_RS08865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LR49_RS08870	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LR49_RS08875	COG0438	transferase activity, transferring glycosyl groups
LR49_RS08910	COG0813	purine-nucleoside phosphorylase activity
LR49_RS08915	COG2814	Major facilitator Superfamily
LR49_RS08935	COG3639	organic phosphonate transmembrane transporter activity
LR49_RS08955	COG0737	Belongs to the 5'-nucleotidase family
LR49_RS08970	COG1454	alcohol dehydrogenase
LR49_RS08970	COG1012	belongs to the aldehyde dehydrogenase family
LR49_RS09000	COG1086	Polysaccharide biosynthesis protein
LR49_RS09010	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LR49_RS09055	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LR49_RS09065	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LR49_RS09070	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LR49_RS09080	COG2832	Protein of unknown function (DUF454)
LR49_RS09115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LR49_RS09120	COG1960	acyl-CoA dehydrogenase activity
LR49_RS09125	COG5609	conserved protein (DUF2294)
LR49_RS09175	COG1114	Component of the transport system for branched-chain amino acids
LR49_RS09190	COG1335	isochorismatase
LR49_RS09195	COG3961	Belongs to the TPP enzyme family
LR49_RS09225	COG1737	Transcriptional regulator
LR49_RS09250	COG0601	transmembrane transport
LR49_RS09255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LR49_RS09265	COG0405	Gamma-glutamyltransferase
LR49_RS09280	COG3842	ATPase activity
LR49_RS09290	COG1175	transmembrane transport
LR49_RS09295	COG3833	ABC-type maltose transport systems, permease component
LR49_RS09300	COG0673	inositol 2-dehydrogenase activity
LR49_RS09305	COG0673	inositol 2-dehydrogenase activity
LR49_RS09315	COG1755	Isoprenylcysteine carboxyl methyltransferase
LR49_RS09370	COG0183	Belongs to the thiolase family
LR49_RS09380	COG1960	acyl-CoA dehydrogenase activity
LR49_RS09385	COG0318	PFAM AMP-dependent synthetase and ligase
LR49_RS09405	COG0747	negative chemotaxis
LR49_RS09410	COG3189	MarR family transcriptional regulator
LR49_RS09450	COG1957	nucleoside hydrolase
LR49_RS09470	COG3414	Phosphotransferase system galactitol-specific IIB component
LR49_RS09475	COG3775	system Galactitol-specific IIC component
LR49_RS09480	COG1063	alcohol dehydrogenase
LR49_RS09490	COG1063	alcohol dehydrogenase
LR49_RS09500	COG1063	alcohol dehydrogenase
LR49_RS09505	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LR49_RS09515	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LR49_RS09525	COG1063	alcohol dehydrogenase
LR49_RS09530	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LR49_RS09570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LR49_RS09580	COG2190	(PTS) system
LR49_RS09580	COG1263	PTS System
LR49_RS09580	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LR49_RS09585	COG2723	6-phospho-beta-galactosidase activity
LR49_RS09595	COG2226	methyltransferase
LR49_RS09645	COG1131	(ABC) transporter
LR49_RS09805	COG1114	Component of the transport system for branched-chain amino acids
LR49_RS09815	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
LR49_RS09825	COG0577	efflux transmembrane transporter activity
LR49_RS09855	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LR49_RS09860	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LR49_RS09885	COG3314	Sporulation integral membrane protein YlbJ
LR49_RS09910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LR49_RS09940	COG3037	sugar-specific permease SgaT UlaA
LR49_RS09950	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LR49_RS09955	COG3711	transcriptional antiterminator
LR49_RS09980	COG2271	Major facilitator Superfamily
LR49_RS09985	COG0346	lactoylglutathione lyase activity
LR49_RS09990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LR49_RS09995	COG0431	NADPH-dependent FMN reductase
LR49_RS10010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LR49_RS10015	COG2822	iron ion transport
LR49_RS10025	COG0672	)-iron permease
LR49_RS10030	COG0805	protein transport
LR49_RS10035	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LR49_RS10045	COG1476	TRANSCRIPTIONal
LR49_RS10055	COG1131	(ABC) transporter
LR49_RS10085	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LR49_RS10085	COG0646	methionine synthase
LR49_RS10090	COG0626	cystathionine gamma-synthase activity
LR49_RS10095	COG0626	cystathionine gamma-synthase activity
LR49_RS10105	COG1475	DNA binding
LR49_RS10110	COG0668	transmembrane transport
LR49_RS10115	COG4481	Protein conserved in bacteria
LR49_RS10120	COG0012	GTP binding
LR49_RS10155	COG4974	Belongs to the 'phage' integrase family
LR49_RS10215	COG3634	alkyl hydroperoxide reductase activity
LR49_RS10230	COG1823	symporter activity
LR49_RS10265	COG2233	PERMEase
LR49_RS10280	COG0582	viral genome integration into host DNA
LR49_RS10340	COG0791	NLP P60 protein
LR49_RS10340	COG0741	lytic transglycosylase activity
LR49_RS10395	COG2946	Replication initiation factor
LR49_RS10400	COG1674	ftsk spoiiie
LR49_RS10465	COG3759	membrane
LR49_RS10625	COG0523	cobalamin synthesis protein
LR49_RS10650	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LR49_RS10660	COG5609	conserved protein (DUF2294)
LR49_RS10675	COG1647	Serine aminopeptidase, S33
LR49_RS10685	COG0733	neurotransmitter:sodium symporter activity
LR49_RS10690	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LR49_RS10695	COG0626	cystathionine gamma-synthase activity
LR49_RS10705	COG2011	ABC-type metal ion transport system permease component
LR49_RS10710	COG1464	Belongs to the NlpA lipoprotein family
LR49_RS10745	COG0583	DNA-binding transcription factor activity
LR49_RS10750	COG0070	glutamate synthase
LR49_RS10750	COG0067	glutamate synthase
LR49_RS10750	COG0069	glutamate synthase activity
LR49_RS10755	COG0493	'glutamate synthase
LR49_RS10765	COG1263	PTS System
LR49_RS10765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LR49_RS10770	COG0366	Alpha amylase catalytic
LR49_RS10775	COG2188	Transcriptional regulator
LR49_RS10795	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LR49_RS10835	COG1982	Orn Lys Arg decarboxylase major
LR49_RS10845	COG3870	Protein conserved in bacteria
LR49_RS10850	COG0470	DNA polymerase III
LR49_RS10855	COG1774	PSP1 C-terminal conserved region
LR49_RS10865	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LR49_RS10875	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LR49_RS10885	COG0084	hydrolase, TatD family'
LR49_RS10890	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
LR49_RS10900	COG4466	Protein conserved in bacteria
LR49_RS10910	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LR49_RS10915	COG0251	oxidation-reduction process
LR49_RS10960	COG2244	polysaccharide biosynthetic process
LR49_RS10965	COG3956	TIGRFAM MazG family protein
LR49_RS10970	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LR49_RS10980	COG1098	S1 RNA binding domain
LR49_RS10995	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LR49_RS11020	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LR49_RS11100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LR49_RS11115	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LR49_RS11125	COG3880	PFAM UvrB UvrC protein
LR49_RS11140	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LR49_RS11145	COG4956	integral membrane protein (PIN domain superfamily)
LR49_RS11170	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
LR49_RS11230	COG2813	Specifically methylates the guanine in position
LR49_RS11270	COG1473	amidohydrolase
LR49_RS11305	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LR49_RS11310	COG1428	Deoxynucleoside kinase
LR49_RS11315	COG1428	Deoxynucleoside kinase
LR49_RS11325	COG0561	phosphatase activity
LR49_RS11370	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LR49_RS11385	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
LR49_RS11485	COG0095	Lipoate-protein ligase
LR49_RS11490	COG0083	homoserine kinase activity
LR49_RS11510	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LR49_RS11605	COG0667	Aldo Keto reductase
LR49_RS11610	COG0655	NAD(P)H dehydrogenase (quinone) activity
LR49_RS11620	COG1078	dGTPase activity
LR49_RS11660	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LR49_RS11665	COG4139	cobalamin transport
LR49_RS11715	COG4974	Belongs to the 'phage' integrase family
LR49_RS11760	COG0803	Belongs to the bacterial solute-binding protein 9 family
LR49_RS11765	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LR49_RS11770	COG1121	(ABC) transporter
LR49_RS11775	COG1321	iron dependent repressor
LR49_RS11785	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
LR49_RS11795	COG1682	transport, permease protein
LR49_RS11800	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LR49_RS11805	COG1216	Glycosyl transferase, family 2
LR49_RS11810	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LR49_RS11815	COG1686	Belongs to the peptidase S11 family
LR49_RS11820	COG1132	(ABC) transporter
LR49_RS11825	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LR49_RS11835	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LR49_RS11840	COG1120	ATPase activity
LR49_RS11845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LR49_RS11850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LR49_RS11855	COG2376	Dihydroxyacetone kinase
LR49_RS11865	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
LR49_RS11875	COG3949	Membrane
LR49_RS11900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LR49_RS11915	COG1136	(ABC) transporter
LR49_RS11920	COG0577	efflux transmembrane transporter activity
LR49_RS11925	COG1392	Phosphate transport regulator
LR49_RS11930	COG0306	phosphate transporter
LR49_RS11935	COG1388	LysM domain
LR49_RS11935	COG3942	CHAP domain
LR49_RS11945	COG4977	sequence-specific DNA binding
LR49_RS11945	COG1917	Cupin 2, conserved barrel domain protein
LR49_RS11975	COG0583	DNA-binding transcription factor activity
LR49_RS11985	COG2814	Major facilitator Superfamily
LR49_RS11990	COG2839	Protein conserved in bacteria
LR49_RS12020	COG1611	Belongs to the LOG family
LR49_RS12040	COG4988	ABC transporter
LR49_RS12045	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LR49_RS12055	COG0523	cobalamin synthesis protein
LR49_RS12060	COG4989	oxidoreductase activity
LR49_RS12070	COG0471	metal ion transport
LR49_RS12075	COG0415	Belongs to the DNA photolyase family
LR49_RS12105	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LR49_RS12110	COG1349	DNA-binding transcription factor activity
LR49_RS12115	COG1105	Belongs to the carbohydrate kinase PfkB family
LR49_RS12120	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LR49_RS12120	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LR49_RS12120	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LR49_RS12125	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LR49_RS12130	COG1253	flavin adenine dinucleotide binding
LR49_RS12135	COG0656	L-ascorbic acid biosynthetic process
LR49_RS12140	COG0463	Glycosyl transferase, family 2
LR49_RS12175	COG0720	synthase
LR49_RS12185	COG0512	Glutamine amidotransferase of anthranilate synthase
LR49_RS12185	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LR49_RS12190	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LR49_RS12220	COG0488	(ABC) transporter
LR49_RS12225	COG0514	ATP-dependent DNA helicase (RecQ)
LR49_RS12230	COG0517	IMP dehydrogenase activity
LR49_RS12230	COG1125	glycine betaine transport
LR49_RS12235	COG1174	glycine betaine transport
LR49_RS12265	COG3104	oligopeptide transport
LR49_RS12295	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LR49_RS12300	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LR49_RS12315	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LR49_RS12320	COG4605	iron ion homeostasis
LR49_RS12325	COG4604	ABC transporter, ATP-binding protein
LR49_RS12330	COG4607	ABC-type enterochelin transport system periplasmic component
LR49_RS12385	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LR49_RS12390	COG1739	Uncharacterized protein family UPF0029
LR49_RS12400	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
LR49_RS12405	COG1040	competence protein
LR49_RS12435	COG1388	LysM domain
LR49_RS12435	COG3942	CHAP domain
LR49_RS12495	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LR49_RS12565	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LR49_RS12570	COG1647	Serine aminopeptidase, S33
LR49_RS12575	COG0557	exoribonuclease II activity
LR49_RS12670	COG5484	DNA packaging
LR49_RS12670	COG3728	DNA packaging
LR49_RS12690	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LR49_RS12695	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LR49_RS12760	COG1278	Cold shock
LR49_RS12800	COG0406	alpha-ribazole phosphatase activity
LR49_RS12805	COG1279	arginine transmembrane transporter activity
LR49_RS12830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LR49_RS12835	COG1393	Belongs to the ArsC family
LR49_RS12885	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LR49_RS12900	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
LR49_RS12915	COG2011	ABC-type metal ion transport system permease component
LR49_RS12920	COG1464	Belongs to the NlpA lipoprotein family
LR49_RS12925	COG0582	viral genome integration into host DNA
LR49_RS13020	COG3728	DNA packaging
LR49_RS13020	COG5484	DNA packaging
LR49_RS13050	COG0396	ATPase activity
LR49_RS13055	COG0719	Fe-S assembly protein
LR49_RS13065	COG0822	iron-sulfur transferase activity
LR49_RS13090	COG1253	flavin adenine dinucleotide binding
LR49_RS13105	COG1801	Protein of unknown function DUF72
LR49_RS13110	COG0730	response to heat
LR49_RS13125	COG4470	Protein conserved in bacteria
LR49_RS13135	COG2445	Protein of unknown function DUF86
LR49_RS13165	COG1696	Membrane protein involved in D-alanine export
LR49_RS13175	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
LR49_RS13180	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LR49_RS13185	COG4837	Protein of unknown function (DUF1462)
LR49_RS13190	COG1252	NADH dehydrogenase
LR49_RS13200	COG0316	Belongs to the HesB IscA family
LR49_RS13215	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LR49_RS13220	COG2056	Na+-H+ antiporter family
LR49_RS13225	COG2050	protein possibly involved in aromatic compounds catabolism
LR49_RS13280	COG1098	S1 RNA binding domain
LR49_RS13285	COG1902	pentaerythritol trinitrate reductase activity
LR49_RS13305	COG0584	glycerophosphoryl diester phosphodiesterase
LR49_RS13325	COG0398	Pfam SNARE associated Golgi protein
LR49_RS13365	COG0561	phosphatase activity
LR49_RS13390	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LR49_RS13425	COG1881	PFAM PEBP family protein
LR49_RS13455	COG0601	transmembrane transport
LR49_RS13460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LR49_RS13465	COG0444	Belongs to the ABC transporter superfamily
LR49_RS13470	COG4608	Belongs to the ABC transporter superfamily
LR49_RS13475	COG4166	transmembrane transport
LR49_RS13480	COG0747	negative chemotaxis
LR49_RS13485	COG0444	Belongs to the ABC transporter superfamily
LR49_RS13490	COG4608	Belongs to the ABC transporter superfamily
LR49_RS13495	COG0601	transmembrane transport
LR49_RS13500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LR49_RS13530	COG1164	Oligoendopeptidase f
LR49_RS13540	COG2346	COG2346, Truncated hemoglobins
LR49_RS13555	COG2357	RelA SpoT domain protein
LR49_RS13565	COG0564	pseudouridine synthase activity
LR49_RS13570	COG2239	Acts as a magnesium transporter
LR49_RS13575	COG0475	glutathione-regulated potassium exporter activity
LR49_RS13575	COG0569	domain protein
LR49_RS13585	COG0628	permease
LR49_RS13590	COG1115	amino acid carrier protein
LR49_RS13630	COG0861	Integral membrane protein TerC family
LR49_RS13640	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LR49_RS13645	COG0737	Belongs to the 5'-nucleotidase family
LR49_RS13660	COG4903	ComK protein
LR49_RS13675	COG4873	Protein conserved in bacteria
LR49_RS13735	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
LR49_RS13745	COG2314	TM2 domain
LR49_RS13750	COG0456	acetyltransferase
LR49_RS13755	COG1575	Belongs to the MenA family. Type 1 subfamily
LR49_RS13765	COG1169	isochorismate synthase
LR49_RS13775	COG2267	carboxylic ester hydrolase activity
LR49_RS13800	COG0436	Aminotransferase
LR49_RS13805	COG3594	Acyltransferase
LR49_RS13840	COG1316	TRANSCRIPTIONal
LR49_RS13845	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LR49_RS13890	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LR49_RS13905	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LR49_RS13935	COG0138	bifunctional purine biosynthesis protein purh
LR49_RS13945	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
LR49_RS13950	COG4172	Belongs to the ABC transporter superfamily
LR49_RS13955	COG4721	ABC-type cobalt transport system, permease component
LR49_RS13980	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LR49_RS14005	COG1271	oxidase subunit
LR49_RS14010	COG1294	oxidase, subunit
LR49_RS14015	COG0569	domain protein
LR49_RS14085	COG1177	transmembrane transport
LR49_RS14090	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LR49_RS14115	COG0483	inositol monophosphate 1-phosphatase activity
LR49_RS14125	COG1217	gtp-binding protein TYPA
LR49_RS14135	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LR49_RS14145	COG0772	Belongs to the SEDS family
LR49_RS14180	COG3679	Belongs to the UPF0342 family
LR49_RS14200	COG0742	ribosomal rna small subunit methyltransferase
LR49_RS14260	COG4509	Sortase family
LR49_RS14275	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LR49_RS14310	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LR49_RS14310	COG1796	DNA polymerase
LR49_RS14335	COG2009	succinate dehydrogenase
LR49_RS14340	COG1053	succinate dehydrogenase
LR49_RS14345	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LR49_RS14475	COG1288	antiporter activity
LR49_RS14510	COG1011	Hydrolase
LR49_RS14535	COG4839	cell division protein FtsL
LR49_RS14540	COG0768	penicillin binding
LR49_RS14555	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LR49_RS14560	COG0849	cell division
LR49_RS14575	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LR49_RS14585	COG0762	integral membrane protein
LR49_RS14590	COG2302	S4 RNA-binding domain
LR49_RS14595	COG3599	regulation of cell shape
LR49_RS14605	COG2514	catechol 2,3-dioxygenase activity
LR49_RS14625	COG0564	pseudouridine synthase activity
LR49_RS14635	COG2233	PERMEase
LR49_RS14680	COG1293	RNA-binding protein homologous to eukaryotic snRNP
LR49_RS14695	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LR49_RS14700	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LR49_RS14715	COG2314	TM2 domain
LR49_RS14730	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LR49_RS14730	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LR49_RS14740	COG0631	protein serine/threonine phosphatase activity
LR49_RS14755	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LR49_RS14770	COG1302	Protein conserved in bacteria
LR49_RS14780	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LR49_RS14820	COG1196	nuclear chromosome segregation
LR49_RS14825	COG0552	protein localization to endoplasmic reticulum
LR49_RS14835	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LR49_RS14895	COG0758	DNA mediated transformation
LR49_RS14995	COG0195	Participates in both transcription termination and antitermination
LR49_RS15000	COG2740	Nucleic-acid-binding protein implicated in transcription termination
LR49_RS15025	COG0196	riboflavin kinase activity
LR49_RS15055	COG2188	Transcriptional regulator
LR49_RS15060	COG0612	Peptidase, M16
LR49_RS15065	COG0612	Peptidase, M16
LR49_RS15070	COG0300	oxidoreductase activity
LR49_RS15090	COG1058	Belongs to the CinA family
LR49_RS15090	COG1546	Belongs to the CinA family
LR49_RS15110	COG1692	metallophosphoesterase
LR49_RS15115	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LR49_RS15115	COG0674	pyruvate-flavodoxin oxidoreductase activity
LR49_RS15120	COG1013	pyruvate-flavodoxin oxidoreductase activity
LR49_RS15155	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
LR49_RS15160	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LR49_RS15185	COG1923	regulation of RNA biosynthetic process
LR49_RS15195	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LR49_RS15200	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
LR49_RS15205	COG0789	Transcriptional regulator