locus-tag	class	description
E5491_RS00015	COG2501	S4 domain
E5491_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E5491_RS00065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E5491_RS00075	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
E5491_RS00085	COG0305	Participates in initiation and elongation during chromosome replication
E5491_RS00120	COG4863	YycH protein
E5491_RS00130	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E5491_RS00135	COG0737	Belongs to the 5'-nucleotidase family
E5491_RS00195	COG0584	glycerophosphoryl diester phosphodiesterase
E5491_RS00200	COG2030	dehydratase
E5491_RS00310	COG0730	response to heat
E5491_RS00315	COG1937	Protein conserved in bacteria
E5491_RS00320	COG2210	Belongs to the sulfur carrier protein TusA family
E5491_RS00325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5491_RS00375	COG0823	Involved in the tonB-independent uptake of proteins
E5491_RS00410	COG1473	amidohydrolase
E5491_RS00420	COG1283	sodium-dependent phosphate transmembrane transporter activity
E5491_RS00425	COG4716	Myosin-crossreactive antigen
E5491_RS00430	COG0697	spore germination
E5491_RS00445	COG1620	l-lactate permease
E5491_RS00465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5491_RS00470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5491_RS00475	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E5491_RS00485	COG2423	ornithine cyclodeaminase activity
E5491_RS00490	COG4264	IucA IucC family
E5491_RS00495	COG2814	Major facilitator Superfamily
E5491_RS00500	COG4264	IucA IucC family
E5491_RS00505	COG4264	IucA IucC family
E5491_RS00515	COG0019	diaminopimelate decarboxylase activity
E5491_RS00520	COG1475	DNA binding
E5491_RS00545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E5491_RS00550	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E5491_RS00555	COG0438	transferase activity, transferring glycosyl groups
E5491_RS00590	COG0813	purine-nucleoside phosphorylase activity
E5491_RS00595	COG2814	Major facilitator Superfamily
E5491_RS00615	COG3639	organic phosphonate transmembrane transporter activity
E5491_RS00635	COG0737	Belongs to the 5'-nucleotidase family
E5491_RS00650	COG1012	belongs to the aldehyde dehydrogenase family
E5491_RS00650	COG1454	alcohol dehydrogenase
E5491_RS00675	COG1086	Polysaccharide biosynthesis protein
E5491_RS00685	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E5491_RS00715	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E5491_RS00725	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E5491_RS00730	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E5491_RS00740	COG2832	Protein of unknown function (DUF454)
E5491_RS00780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5491_RS00785	COG1960	acyl-CoA dehydrogenase activity
E5491_RS00790	COG5609	conserved protein (DUF2294)
E5491_RS00840	COG1114	Component of the transport system for branched-chain amino acids
E5491_RS00845	COG1335	isochorismatase
E5491_RS00850	COG3961	Belongs to the TPP enzyme family
E5491_RS00880	COG1737	Transcriptional regulator
E5491_RS00905	COG1136	(ABC) transporter
E5491_RS00930	COG1131	(ABC) transporter
E5491_RS00950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5491_RS00960	COG0405	Gamma-glutamyltransferase
E5491_RS00980	COG3842	ATPase activity
E5491_RS00990	COG1175	transmembrane transport
E5491_RS00995	COG3833	ABC-type maltose transport systems, permease component
E5491_RS01000	COG0673	inositol 2-dehydrogenase activity
E5491_RS01005	COG0673	inositol 2-dehydrogenase activity
E5491_RS01015	COG1755	Isoprenylcysteine carboxyl methyltransferase
E5491_RS01070	COG0183	Belongs to the thiolase family
E5491_RS01080	COG1960	acyl-CoA dehydrogenase activity
E5491_RS01085	COG0318	PFAM AMP-dependent synthetase and ligase
E5491_RS01100	COG0747	negative chemotaxis
E5491_RS01105	COG3189	MarR family transcriptional regulator
E5491_RS01130	COG1263	PTS System
E5491_RS01130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5491_RS01130	COG2190	(PTS) system
E5491_RS01135	COG1957	nucleoside hydrolase
E5491_RS01155	COG3414	Phosphotransferase system galactitol-specific IIB component
E5491_RS01160	COG3775	system Galactitol-specific IIC component
E5491_RS01165	COG1063	alcohol dehydrogenase
E5491_RS01185	COG1063	alcohol dehydrogenase
E5491_RS01190	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E5491_RS01195	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E5491_RS01205	COG1063	alcohol dehydrogenase
E5491_RS01210	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E5491_RS01245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5491_RS01250	COG2190	(PTS) system
E5491_RS01250	COG1263	PTS System
E5491_RS01250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5491_RS01255	COG2723	6-phospho-beta-galactosidase activity
E5491_RS01260	COG2226	methyltransferase
E5491_RS01315	COG1131	(ABC) transporter
E5491_RS01335	COG3942	CHAP domain
E5491_RS01335	COG1388	LysM domain
E5491_RS01455	COG1114	Component of the transport system for branched-chain amino acids
E5491_RS01465	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
E5491_RS01475	COG0577	efflux transmembrane transporter activity
E5491_RS01505	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E5491_RS01510	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E5491_RS01535	COG3314	Sporulation integral membrane protein YlbJ
E5491_RS01560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5491_RS01590	COG3037	sugar-specific permease SgaT UlaA
E5491_RS01600	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5491_RS01605	COG3711	transcriptional antiterminator
E5491_RS01630	COG2271	Major facilitator Superfamily
E5491_RS01635	COG0346	lactoylglutathione lyase activity
E5491_RS01640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5491_RS01645	COG0431	NADPH-dependent FMN reductase
E5491_RS01660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E5491_RS01665	COG2822	iron ion transport
E5491_RS01675	COG0672	)-iron permease
E5491_RS01680	COG0805	protein transport
E5491_RS01685	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E5491_RS01695	COG1476	TRANSCRIPTIONal
E5491_RS01705	COG1131	(ABC) transporter
E5491_RS01735	COG0646	methionine synthase
E5491_RS01735	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E5491_RS01740	COG0626	cystathionine gamma-synthase activity
E5491_RS01745	COG0626	cystathionine gamma-synthase activity
E5491_RS01755	COG1475	DNA binding
E5491_RS01760	COG0668	transmembrane transport
E5491_RS01765	COG4481	Protein conserved in bacteria
E5491_RS01770	COG0012	GTP binding
E5491_RS01885	COG5484	DNA packaging
E5491_RS01885	COG3728	DNA packaging
E5491_RS02000	COG1823	symporter activity
E5491_RS02035	COG2233	PERMEase
E5491_RS02070	COG3759	membrane
E5491_RS02230	COG0523	cobalamin synthesis protein
E5491_RS02255	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E5491_RS02265	COG5609	conserved protein (DUF2294)
E5491_RS02280	COG1647	Serine aminopeptidase, S33
E5491_RS02285	COG0733	neurotransmitter:sodium symporter activity
E5491_RS02290	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E5491_RS02295	COG0626	cystathionine gamma-synthase activity
E5491_RS02305	COG2011	ABC-type metal ion transport system permease component
E5491_RS02310	COG1464	Belongs to the NlpA lipoprotein family
E5491_RS02345	COG0583	DNA-binding transcription factor activity
E5491_RS02350	COG0070	glutamate synthase
E5491_RS02350	COG0069	glutamate synthase activity
E5491_RS02350	COG0067	glutamate synthase
E5491_RS02355	COG0493	'glutamate synthase
E5491_RS02365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5491_RS02365	COG1263	PTS System
E5491_RS02370	COG0366	Alpha amylase catalytic
E5491_RS02375	COG2188	Transcriptional regulator
E5491_RS02395	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E5491_RS02435	COG1982	Orn Lys Arg decarboxylase major
E5491_RS02445	COG3870	Protein conserved in bacteria
E5491_RS02450	COG0470	DNA polymerase III
E5491_RS02455	COG1774	PSP1 C-terminal conserved region
E5491_RS02465	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E5491_RS02475	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E5491_RS02485	COG0084	hydrolase, TatD family'
E5491_RS02490	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
E5491_RS02500	COG4466	Protein conserved in bacteria
E5491_RS02510	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E5491_RS02515	COG0251	oxidation-reduction process
E5491_RS02560	COG2244	polysaccharide biosynthetic process
E5491_RS02565	COG3956	TIGRFAM MazG family protein
E5491_RS02570	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E5491_RS02580	COG1098	S1 RNA binding domain
E5491_RS02595	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E5491_RS02620	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E5491_RS02715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5491_RS02730	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E5491_RS02740	COG3880	PFAM UvrB UvrC protein
E5491_RS02755	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E5491_RS02760	COG4956	integral membrane protein (PIN domain superfamily)
E5491_RS02785	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
E5491_RS02845	COG2813	Specifically methylates the guanine in position
E5491_RS02885	COG1473	amidohydrolase
E5491_RS02915	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E5491_RS02920	COG1428	Deoxynucleoside kinase
E5491_RS02925	COG1428	Deoxynucleoside kinase
E5491_RS02935	COG0561	phosphatase activity
E5491_RS02980	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E5491_RS02995	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
E5491_RS03095	COG0095	Lipoate-protein ligase
E5491_RS03100	COG0083	homoserine kinase activity
E5491_RS03120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E5491_RS03155	COG0667	Aldo Keto reductase
E5491_RS03165	COG0655	NAD(P)H dehydrogenase (quinone) activity
E5491_RS03175	COG1078	dGTPase activity
E5491_RS03210	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E5491_RS03215	COG4139	cobalamin transport
E5491_RS03265	COG4974	Belongs to the 'phage' integrase family
E5491_RS03310	COG0803	Belongs to the bacterial solute-binding protein 9 family
E5491_RS03315	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E5491_RS03320	COG1121	(ABC) transporter
E5491_RS03325	COG1321	iron dependent repressor
E5491_RS03335	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
E5491_RS03345	COG1682	transport, permease protein
E5491_RS03350	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E5491_RS03360	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E5491_RS03365	COG1686	Belongs to the peptidase S11 family
E5491_RS03370	COG1132	(ABC) transporter
E5491_RS03375	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E5491_RS03385	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E5491_RS03390	COG1120	ATPase activity
E5491_RS03395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5491_RS03400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5491_RS03405	COG2376	Dihydroxyacetone kinase
E5491_RS03415	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
E5491_RS03425	COG3949	Membrane
E5491_RS03450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E5491_RS03465	COG1136	(ABC) transporter
E5491_RS03470	COG0577	efflux transmembrane transporter activity
E5491_RS03475	COG1392	Phosphate transport regulator
E5491_RS03480	COG0306	phosphate transporter
E5491_RS03485	COG3942	CHAP domain
E5491_RS03485	COG1388	LysM domain
E5491_RS03495	COG1917	Cupin 2, conserved barrel domain protein
E5491_RS03495	COG4977	sequence-specific DNA binding
E5491_RS03525	COG0583	DNA-binding transcription factor activity
E5491_RS03530	COG2814	Major facilitator Superfamily
E5491_RS03535	COG2839	Protein conserved in bacteria
E5491_RS03565	COG1611	Belongs to the LOG family
E5491_RS03585	COG4988	ABC transporter
E5491_RS03590	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E5491_RS03600	COG0523	cobalamin synthesis protein
E5491_RS03605	COG4989	oxidoreductase activity
E5491_RS03615	COG0471	metal ion transport
E5491_RS03620	COG0415	Belongs to the DNA photolyase family
E5491_RS03650	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E5491_RS03655	COG1349	DNA-binding transcription factor activity
E5491_RS03660	COG1105	Belongs to the carbohydrate kinase PfkB family
E5491_RS03665	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5491_RS03665	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E5491_RS03665	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E5491_RS03670	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E5491_RS03675	COG1253	flavin adenine dinucleotide binding
E5491_RS03680	COG0656	L-ascorbic acid biosynthetic process
E5491_RS03685	COG0463	Glycosyl transferase, family 2
E5491_RS03720	COG0720	synthase
E5491_RS03730	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E5491_RS03730	COG0512	Glutamine amidotransferase of anthranilate synthase
E5491_RS03735	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E5491_RS03765	COG0488	(ABC) transporter
E5491_RS03770	COG0514	ATP-dependent DNA helicase (RecQ)
E5491_RS03775	COG1125	glycine betaine transport
E5491_RS03775	COG0517	IMP dehydrogenase activity
E5491_RS03780	COG1174	glycine betaine transport
E5491_RS03810	COG3104	oligopeptide transport
E5491_RS03840	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E5491_RS03845	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E5491_RS03855	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5491_RS03860	COG4605	iron ion homeostasis
E5491_RS03865	COG4604	ABC transporter, ATP-binding protein
E5491_RS03870	COG4607	ABC-type enterochelin transport system periplasmic component
E5491_RS03925	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E5491_RS03930	COG1739	Uncharacterized protein family UPF0029
E5491_RS03940	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
E5491_RS03945	COG1040	competence protein
E5491_RS03975	COG1388	LysM domain
E5491_RS03975	COG3942	CHAP domain
E5491_RS04035	COG0391	Required for morphogenesis under gluconeogenic growth conditions
E5491_RS04105	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E5491_RS04110	COG1647	Serine aminopeptidase, S33
E5491_RS04115	COG0557	exoribonuclease II activity
E5491_RS04190	COG1278	Cold shock
E5491_RS04230	COG0406	alpha-ribazole phosphatase activity
E5491_RS04235	COG1279	arginine transmembrane transporter activity
E5491_RS04260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E5491_RS04265	COG1393	Belongs to the ArsC family
E5491_RS04280	COG3878	Protein conserved in bacteria
E5491_RS04285	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
E5491_RS04300	COG2011	ABC-type metal ion transport system permease component
E5491_RS04305	COG1464	Belongs to the NlpA lipoprotein family
E5491_RS04320	COG0396	ATPase activity
E5491_RS04325	COG0719	Fe-S assembly protein
E5491_RS04335	COG0822	iron-sulfur transferase activity
E5491_RS04360	COG1253	flavin adenine dinucleotide binding
E5491_RS04375	COG1801	Protein of unknown function DUF72
E5491_RS04380	COG0730	response to heat
E5491_RS04395	COG4470	Protein conserved in bacteria
E5491_RS04410	COG2445	Protein of unknown function DUF86
E5491_RS04440	COG1696	Membrane protein involved in D-alanine export
E5491_RS04450	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
E5491_RS04455	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E5491_RS04460	COG4837	Protein of unknown function (DUF1462)
E5491_RS04465	COG1252	NADH dehydrogenase
E5491_RS04475	COG0316	Belongs to the HesB IscA family
E5491_RS04485	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E5491_RS04490	COG2056	Na+-H+ antiporter family
E5491_RS04495	COG2050	protein possibly involved in aromatic compounds catabolism
E5491_RS04550	COG1098	S1 RNA binding domain
E5491_RS04555	COG1902	pentaerythritol trinitrate reductase activity
E5491_RS04570	COG0584	glycerophosphoryl diester phosphodiesterase
E5491_RS04590	COG0398	Pfam SNARE associated Golgi protein
E5491_RS04630	COG0561	phosphatase activity
E5491_RS04655	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E5491_RS04670	COG1881	PFAM PEBP family protein
E5491_RS04700	COG0601	transmembrane transport
E5491_RS04705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5491_RS04710	COG0444	Belongs to the ABC transporter superfamily
E5491_RS04715	COG4608	Belongs to the ABC transporter superfamily
E5491_RS04720	COG4166	transmembrane transport
E5491_RS04725	COG0747	negative chemotaxis
E5491_RS04730	COG0444	Belongs to the ABC transporter superfamily
E5491_RS04735	COG4608	Belongs to the ABC transporter superfamily
E5491_RS04740	COG0601	transmembrane transport
E5491_RS04745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5491_RS04775	COG1164	Oligoendopeptidase f
E5491_RS04785	COG2346	COG2346, Truncated hemoglobins
E5491_RS04800	COG2357	RelA SpoT domain protein
E5491_RS04810	COG0564	pseudouridine synthase activity
E5491_RS04815	COG2239	Acts as a magnesium transporter
E5491_RS04820	COG0569	domain protein
E5491_RS04820	COG0475	glutathione-regulated potassium exporter activity
E5491_RS04830	COG0628	permease
E5491_RS04835	COG1115	amino acid carrier protein
E5491_RS04875	COG0861	Integral membrane protein TerC family
E5491_RS04885	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E5491_RS04890	COG0737	Belongs to the 5'-nucleotidase family
E5491_RS04905	COG4903	ComK protein
E5491_RS04920	COG4873	Protein conserved in bacteria
E5491_RS04975	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
E5491_RS04985	COG2314	TM2 domain
E5491_RS04990	COG0456	acetyltransferase
E5491_RS04995	COG1575	Belongs to the MenA family. Type 1 subfamily
E5491_RS05005	COG1169	isochorismate synthase
E5491_RS05015	COG2267	carboxylic ester hydrolase activity
E5491_RS05040	COG0436	Aminotransferase
E5491_RS05045	COG3594	Acyltransferase
E5491_RS05075	COG1316	TRANSCRIPTIONal
E5491_RS05120	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E5491_RS05135	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E5491_RS05175	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
E5491_RS05180	COG4172	Belongs to the ABC transporter superfamily
E5491_RS05185	COG4721	ABC-type cobalt transport system, permease component
E5491_RS05210	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E5491_RS05230	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E5491_RS05235	COG1271	oxidase subunit
E5491_RS05240	COG1294	oxidase, subunit
E5491_RS05245	COG0569	domain protein
E5491_RS05310	COG1176	ABC-type spermidine putrescine transport system, permease component I
E5491_RS05315	COG1177	transmembrane transport
E5491_RS05320	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E5491_RS05350	COG0483	inositol monophosphate 1-phosphatase activity
E5491_RS05360	COG1217	gtp-binding protein TYPA
E5491_RS05370	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E5491_RS05380	COG0772	Belongs to the SEDS family
E5491_RS05415	COG3679	Belongs to the UPF0342 family
E5491_RS05435	COG0742	ribosomal rna small subunit methyltransferase
E5491_RS05495	COG4509	Sortase family
E5491_RS05510	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E5491_RS05550	COG1796	DNA polymerase
E5491_RS05550	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E5491_RS05575	COG2009	succinate dehydrogenase
E5491_RS05580	COG1053	succinate dehydrogenase
E5491_RS05585	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E5491_RS05710	COG1288	antiporter activity
E5491_RS05750	COG1011	Hydrolase
E5491_RS05775	COG4839	cell division protein FtsL
E5491_RS05780	COG0768	penicillin binding
E5491_RS05795	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E5491_RS05800	COG0849	cell division
E5491_RS05815	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E5491_RS05825	COG0762	integral membrane protein
E5491_RS05830	COG2302	S4 RNA-binding domain
E5491_RS05835	COG3599	regulation of cell shape
E5491_RS05845	COG2514	catechol 2,3-dioxygenase activity
E5491_RS05865	COG0564	pseudouridine synthase activity
E5491_RS05875	COG2233	PERMEase
E5491_RS05920	COG1293	RNA-binding protein homologous to eukaryotic snRNP
E5491_RS05935	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E5491_RS05940	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E5491_RS05950	COG2314	TM2 domain
E5491_RS05965	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E5491_RS05965	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E5491_RS05975	COG0631	protein serine/threonine phosphatase activity
E5491_RS05990	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E5491_RS06005	COG1302	Protein conserved in bacteria
E5491_RS06055	COG1196	nuclear chromosome segregation
E5491_RS06060	COG0552	protein localization to endoplasmic reticulum
E5491_RS06070	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E5491_RS06145	COG1484	DNA-dependent DNA replication
E5491_RS06205	COG0756	dUTP diphosphatase activity
E5491_RS06240	COG1783	phage Terminase large subunit
E5491_RS06370	COG1388	LysM domain
E5491_RS06370	COG0860	N-Acetylmuramoyl-L-alanine amidase
E5491_RS06445	COG2348	transferase activity, transferring amino-acyl groups
E5491_RS06550	COG0195	Participates in both transcription termination and antitermination
E5491_RS06555	COG2740	Nucleic-acid-binding protein implicated in transcription termination
E5491_RS06580	COG0196	riboflavin kinase activity
E5491_RS06610	COG2188	Transcriptional regulator
E5491_RS06615	COG0612	Peptidase, M16
E5491_RS06620	COG0612	Peptidase, M16
E5491_RS06625	COG0300	oxidoreductase activity
E5491_RS06645	COG1058	Belongs to the CinA family
E5491_RS06645	COG1546	Belongs to the CinA family
E5491_RS06665	COG1692	metallophosphoesterase
E5491_RS06670	COG0674	pyruvate-flavodoxin oxidoreductase activity
E5491_RS06670	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E5491_RS06675	COG1013	pyruvate-flavodoxin oxidoreductase activity
E5491_RS06710	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
E5491_RS06715	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E5491_RS06740	COG1923	regulation of RNA biosynthetic process
E5491_RS06750	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E5491_RS06755	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
E5491_RS06760	COG0789	Transcriptional regulator
E5491_RS06845	COG1131	(ABC) transporter
E5491_RS06860	COG2197	response regulator
E5491_RS06870	COG1525	nuclease
E5491_RS06885	COG0527	aspartate kinase activity
E5491_RS06890	COG0460	homoserine dehydrogenase
E5491_RS06895	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E5491_RS06920	COG0833	amino acid
E5491_RS06950	COG2340	Cysteine-rich secretory protein family
E5491_RS06985	COG4846	Membrane protein involved in cytochrome C biogenesis
E5491_RS07005	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E5491_RS07020	COG0824	Thioesterase
E5491_RS07055	COG1115	amino acid carrier protein
E5491_RS07070	COG0628	permease
E5491_RS07095	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E5491_RS07105	COG1363	Peptidase, m42
E5491_RS07110	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E5491_RS07115	COG0512	Glutamine amidotransferase of anthranilate synthase
E5491_RS07205	COG0704	Plays a role in the regulation of phosphate uptake
E5491_RS07215	COG0581	inorganic phosphate transmembrane transporter activity
E5491_RS07220	COG0573	inorganic phosphate transmembrane transporter activity
E5491_RS07240	COG0488	(ABC) transporter
E5491_RS07250	COG0527	aspartate kinase activity
E5491_RS07255	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E5491_RS07330	COG4548	von Willebrand factor, type A
E5491_RS07335	COG0714	Associated with various cellular activities
E5491_RS07380	COG0671	phosphoesterase, PA-phosphatase related
E5491_RS07455	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E5491_RS07480	COG0531	amino acid
E5491_RS07495	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E5491_RS07500	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
E5491_RS07515	COG0116	Belongs to the methyltransferase superfamily
E5491_RS07555	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E5491_RS07555	COG4499	WXG100 protein secretion system (Wss), protein YukC
E5491_RS07565	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E5491_RS07570	COG3935	DnaD domain protein
E5491_RS07595	COG0438	transferase activity, transferring glycosyl groups
E5491_RS07600	COG1694	Mazg nucleotide pyrophosphohydrolase
E5491_RS07605	COG2738	Putative neutral zinc metallopeptidase
E5491_RS07610	COG4347	Protein of unknown function (DUF1405)
E5491_RS07650	COG0142	geranyltranstransferase activity
E5491_RS07715	COG0492	ferredoxin-NADP+ reductase activity
E5491_RS07730	COG0514	ATP-dependent DNA helicase (RecQ)
E5491_RS07740	COG1141	Ferredoxin
E5491_RS07785	COG1388	LysM domain
E5491_RS07785	COG0860	N-Acetylmuramoyl-L-alanine amidase
E5491_RS07835	COG3953	SLT domain
E5491_RS07835	COG5280	Phage tail tape measure protein TP901
E5491_RS07955	COG0756	dUTP diphosphatase activity
E5491_RS08095	COG0582	viral genome integration into host DNA
E5491_RS08115	COG0745	RESPONSE REGULATOR receiver
E5491_RS08120	COG1187	pseudouridine synthase activity
E5491_RS08145	COG0735	belongs to the Fur family
E5491_RS08150	COG0494	nUDIX hydrolase
E5491_RS08155	COG0667	Aldo Keto reductase
E5491_RS08165	COG4221	oxidoreductase activity
E5491_RS08180	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E5491_RS08190	COG0366	Alpha amylase catalytic
E5491_RS08195	COG1609	Transcriptional regulator
E5491_RS08220	COG2195	Cleaves the N-terminal amino acid of tripeptides
E5491_RS08230	COG4129	membrane
E5491_RS08240	COG0508	dehydrogenase complex catalyzes the overall conversion of
E5491_RS08245	COG0022	dehydrogenase e1 component
E5491_RS08250	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E5491_RS08255	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E5491_RS08260	COG0497	DNA recombination
E5491_RS08290	COG1302	Protein conserved in bacteria
E5491_RS08295	COG0439	Biotin carboxylase
E5491_RS08300	COG0511	ligase activity, forming carbon-carbon bonds
E5491_RS08310	COG0006	proline dipeptidase activity
E5491_RS08325	COG0095	Lipoate-protein ligase
E5491_RS08330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E5491_RS08375	COG4537	Required for transformation and DNA binding
E5491_RS08380	COG1459	type II secretion system
E5491_RS08385	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E5491_RS08390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5491_RS08395	COG0011	TIGRFAM Protein of
E5491_RS08400	COG1940	carbohydrate kinase activity
E5491_RS08405	COG4483	Protein conserved in bacteria
E5491_RS08415	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E5491_RS08425	COG0768	penicillin binding
E5491_RS08440	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E5491_RS08445	COG1121	(ABC) transporter
E5491_RS08455	COG0513	Belongs to the DEAD box helicase family
E5491_RS08465	COG2384	SAM-dependent methyltransferase
E5491_RS08485	COG0517	IMP dehydrogenase activity
E5491_RS08505	COG0295	cytidine deaminase activity
E5491_RS08520	COG1702	phosphate starvation-inducible protein PhoH
E5491_RS08535	COG1030	water channel activity
E5491_RS08545	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E5491_RS08550	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E5491_RS08580	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E5491_RS08595	COG1466	dna polymerase III delta subunit
E5491_RS08600	COG2333	competence protein COMEC
E5491_RS08600	COG0658	competence protein
E5491_RS08605	COG2131	deaminase
E5491_RS08610	COG2183	response to ionizing radiation
E5491_RS08615	COG2226	methyltransferase
E5491_RS08620	COG0799	negative regulation of ribosome biogenesis
E5491_RS08625	COG1713	HD superfamily hydrolase involved in NAD metabolism
E5491_RS08635	COG1534	Rna-binding protein
E5491_RS08645	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
E5491_RS08650	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
E5491_RS08685	COG3177	Filamentation induced by cAMP protein fic
E5491_RS08690	COG1914	H( )-stimulated, divalent metal cation uptake system
E5491_RS08700	COG0439	Biotin carboxylase
E5491_RS08705	COG0511	ligase activity, forming carbon-carbon bonds
E5491_RS08710	COG1984	allophanate hydrolase subunit 2
E5491_RS08715	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E5491_RS08730	COG0826	peptidase U32
E5491_RS08735	COG0826	peptidase U32
E5491_RS08765	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E5491_RS08780	COG1104	cysteine desulfurase activity
E5491_RS08785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5491_RS08795	COG3237	CsbD-like
E5491_RS08800	COG1959	2 iron, 2 sulfur cluster binding
E5491_RS08805	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E5491_RS08810	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E5491_RS08855	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E5491_RS08855	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E5491_RS08860	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E5491_RS08860	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E5491_RS08865	COG1862	Preprotein translocase
E5491_RS08905	COG2868	ribosomal protein
E5491_RS08950	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
E5491_RS08960	COG0285	dihydrofolate synthase activity
E5491_RS08970	COG2818	Glycosylase
E5491_RS09005	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E5491_RS09040	COG4112	unkown
E5491_RS09065	COG0833	amino acid
E5491_RS09080	COG1484	DNA-dependent DNA replication
E5491_RS09110	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E5491_RS09110	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E5491_RS09120	COG5002	protein histidine kinase activity
E5491_RS09125	COG0745	RESPONSE REGULATOR receiver
E5491_RS09140	COG0372	Belongs to the citrate synthase family
E5491_RS09145	COG1113	amino acid transport
E5491_RS09170	COG0281	malic enzyme
E5491_RS09180	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E5491_RS09190	COG4109	DRTGG domain
E5491_RS09230	COG0827	DNA restriction-modification system
E5491_RS09240	COG0730	response to heat
E5491_RS09250	COG1104	cysteine desulfurase activity
E5491_RS09265	COG1956	GAF domain-containing protein
E5491_RS09285	COG0584	glycerophosphoryl diester phosphodiesterase
E5491_RS09290	COG1764	response to oxidative stress
E5491_RS09295	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E5491_RS09300	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E5491_RS09315	COG1263	PTS System
E5491_RS09315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5491_RS09320	COG0204	Acyl-transferase
E5491_RS09325	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5491_RS09360	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5491_RS09365	COG0454	-acetyltransferase
E5491_RS09385	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
E5491_RS09385	COG1605	Chorismate mutase
E5491_RS09410	COG1674	ftsk spoiiie
E5491_RS09415	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5491_RS09425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E5491_RS09430	COG1363	Peptidase, m42
E5491_RS09440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5491_RS09450	COG0510	thiamine kinase activity
E5491_RS09470	COG1187	pseudouridine synthase activity
E5491_RS09475	COG2244	polysaccharide biosynthetic process
E5491_RS09480	COG2081	HI0933 family
E5491_RS09500	COG2814	Major facilitator Superfamily
E5491_RS09505	COG1242	4 iron, 4 sulfur cluster binding
E5491_RS09510	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
E5491_RS09520	COG2267	carboxylic ester hydrolase activity
E5491_RS09550	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E5491_RS09550	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E5491_RS09570	COG3266	domain, Protein
E5491_RS09570	COG4193	domain, Protein
E5491_RS09570	COG5632	N-Acetylmuramoyl-L-alanine amidase
E5491_RS09600	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E5491_RS09625	COG0656	L-ascorbic acid biosynthetic process
E5491_RS09645	COG1506	peptidase
E5491_RS09650	COG2816	NAD+ diphosphatase activity
E5491_RS09885	COG1388	LysM domain
E5491_RS09885	COG0860	N-Acetylmuramoyl-L-alanine amidase
E5491_RS10050	COG0756	dUTP diphosphatase activity
E5491_RS10110	COG0305	Participates in initiation and elongation during chromosome replication
E5491_RS10255	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
E5491_RS10285	COG1131	(ABC) transporter
E5491_RS10290	COG0537	adenosine 5'-monophosphoramidase activity
E5491_RS10320	COG0420	3'-5' exonuclease activity
E5491_RS10350	COG2197	response regulator
E5491_RS10355	COG2203	Gaf domain
E5491_RS10355	COG4585	Histidine kinase
E5491_RS10360	COG0564	pseudouridine synthase activity
E5491_RS10390	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E5491_RS10395	COG1126	abc transporter atp-binding protein
E5491_RS10400	COG0765	amino acid transport
E5491_RS10570	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E5491_RS10575	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E5491_RS10585	COG4129	membrane
E5491_RS10610	COG1988	membrane-bound metal-dependent
E5491_RS10625	COG1388	LysM domain
E5491_RS10625	COG1134	teichoic acid transport
E5491_RS10655	COG0535	radical SAM domain protein
E5491_RS10660	COG1607	acyl-coa hydrolase
E5491_RS10665	COG2309	aminopeptidase activity
E5491_RS10685	COG1295	ribonuclease BN
E5491_RS10810	COG4851	CamS sex pheromone cAM373 precursor
E5491_RS10830	COG4496	protein, YerC YecD
E5491_RS10870	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E5491_RS10880	COG0077	Prephenate dehydratase
E5491_RS10890	COG0471	metal ion transport
E5491_RS10900	COG1335	isochorismatase
E5491_RS10915	COG1012	belongs to the aldehyde dehydrogenase family
E5491_RS10970	COG1131	(ABC) transporter
E5491_RS10985	COG1725	Transcriptional regulator
E5491_RS11065	COG1388	LysM domain
E5491_RS11065	COG5632	N-Acetylmuramoyl-L-alanine amidase
E5491_RS11165	COG0740	serine-type endopeptidase activity
E5491_RS11370	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E5491_RS11440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E5491_RS11445	COG1621	beta-fructofuranosidase activity
E5491_RS11450	COG1609	Transcriptional regulator
E5491_RS11455	COG0004	ammonium transporteR
E5491_RS11460	COG0425	Belongs to the sulfur carrier protein TusA family
E5491_RS11465	COG2391	methyltransferase activity
E5491_RS11475	COG0488	(ABC) transporter
E5491_RS11485	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E5491_RS11495	COG0456	acetyltransferase
E5491_RS11500	COG1214	PFAM Peptidase M22, glycoprotease
E5491_RS11505	COG0802	atpase or kinase
E5491_RS11520	COG0028	Belongs to the TPP enzyme family
E5491_RS11595	COG2183	response to ionizing radiation
E5491_RS11600	COG1191	sigma factor activity
E5491_RS11610	COG1366	Belongs to the anti-sigma-factor antagonist family
E5491_RS11615	COG2208	phosphoserine phosphatase activity
E5491_RS11650	COG3428	Bacterial PH domain
E5491_RS11680	COG2205	protein histidine kinase activity
E5491_RS11685	COG0745	RESPONSE REGULATOR receiver
E5491_RS11695	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E5491_RS11705	COG0772	Belongs to the SEDS family
E5491_RS11720	COG1937	Protein conserved in bacteria
E5491_RS11730	COG1418	mRNA catabolic process
E5491_RS11785	COG0629	single-stranded DNA binding
E5491_RS11860	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E5491_RS11885	COG0009	L-threonylcarbamoyladenylate synthase
E5491_RS11890	COG2890	protein-(glutamine-N5) methyltransferase activity
E5491_RS11915	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E5491_RS11955	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E5491_RS12005	COG0813	purine-nucleoside phosphorylase activity
E5491_RS12010	COG0783	Belongs to the Dps family
E5491_RS12030	COG1482	cell wall glycoprotein biosynthetic process
E5491_RS12035	COG0702	epimerase
E5491_RS12040	COG0640	Transcriptional regulator
E5491_RS12075	COG0561	phosphatase activity
E5491_RS12080	COG1119	ATPase activity
E5491_RS12095	COG3711	transcriptional antiterminator
E5491_RS12125	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
E5491_RS12185	COG0489	protein tyrosine kinase activity
E5491_RS12190	COG2814	Major facilitator Superfamily
E5491_RS12205	COG1272	protein, Hemolysin III
E5491_RS12215	COG1988	membrane-bound metal-dependent
E5491_RS12225	COG3314	Sporulation integral membrane protein YlbJ
E5491_RS12230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5491_RS12235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5491_RS12240	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
E5491_RS12250	COG3457	Alanine racemase
E5491_RS12255	COG4264	IucA IucC family
E5491_RS12260	COG2814	Major facilitator Superfamily
E5491_RS12285	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E5491_RS12295	COG2130	NADP-dependent
E5491_RS12360	COG0656	L-ascorbic acid biosynthetic process
E5491_RS12365	COG0789	Transcriptional regulator
E5491_RS12375	COG5492	domain, Protein
E5491_RS12395	COG3527	Alpha-acetolactate decarboxylase
E5491_RS12400	COG0028	Belongs to the TPP enzyme family
E5491_RS12515	COG0201	protein transport
E5491_RS12630	COG2252	PERMEase
E5491_RS12735	COG1763	Mo-molybdopterin cofactor biosynthetic process
E5491_RS12755	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E5491_RS12760	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
E5491_RS12765	COG4149	molybdate abc transporter
E5491_RS12770	COG0725	ABC transporter, periplasmic molybdate-binding protein
E5491_RS12785	COG1268	BioY protein
E5491_RS12800	COG1960	acyl-CoA dehydrogenase activity
E5491_RS12805	COG4413	Urea transporter
E5491_RS12870	COG3942	CHAP domain
E5491_RS12880	COG1757	Na H antiporter
E5491_RS12895	COG3942	CHAP domain
E5491_RS12965	COG1113	amino acid transport
E5491_RS12985	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E5491_RS12990	COG0385	Bile acid
E5491_RS13000	COG1263	PTS System
E5491_RS13000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5491_RS13005	COG1737	Transcriptional regulator
E5491_RS13025	COG1028	Short-chain dehydrogenase reductase Sdr
E5491_RS13030	COG1473	amidohydrolase
E5491_RS13045	COG0583	DNA-binding transcription factor activity
E5491_RS13070	COG2258	MOSC domain
E5491_RS13090	COG1668	transmembrane transport
E5491_RS13095	COG4152	abc transporter atp-binding protein
E5491_RS13100	COG3152	Membrane
E5491_RS13120	COG0786	glutamate:sodium symporter activity
E5491_RS13130	COG0598	Magnesium transport protein CorA
E5491_RS13145	COG0657	acetylesterase activity
E5491_RS13155	COG2814	Major facilitator Superfamily
E5491_RS13160	COG1566	PFAM secretion protein HlyD family protein
E5491_RS13170	COG2814	Major facilitator Superfamily
E5491_RS13235	COG1620	l-lactate permease
E5491_RS13255	COG0604	alcohol dehydrogenase
E5491_RS13285	COG1511	domain protein
E5491_RS13300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5491_RS13300	COG1263	PTS System
E5491_RS13315	COG3871	stress protein (general stress protein 26)
E5491_RS13355	COG0789	Transcriptional regulator
E5491_RS13375	COG2181	nitrate reductase activity
E5491_RS13385	COG1140	nitrate reductase beta subunit
E5491_RS13390	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
E5491_RS13400	COG2146	nitrite reductase [NAD(P)H] activity
E5491_RS13405	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E5491_RS13415	COG0454	-acetyltransferase
E5491_RS13420	COG2116	formate transmembrane transporter activity
E5491_RS13435	COG0803	Belongs to the bacterial solute-binding protein 9 family
E5491_RS13435	COG3443	Belongs to the bacterial solute-binding protein 9 family
E5491_RS13475	COG1126	abc transporter atp-binding protein
E5491_RS13480	COG0765	amino acid transport
E5491_RS13485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5491_RS13490	COG2814	Major facilitator Superfamily
E5491_RS13510	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E5491_RS13560	COG0156	8-amino-7-oxononanoate synthase activity
E5491_RS13570	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E5491_RS13575	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E5491_RS13590	COG1132	(ABC) transporter
E5491_RS13595	COG1132	(ABC) transporter
E5491_RS13595	COG2375	cellular response to nickel ion
E5491_RS13615	COG1929	Belongs to the glycerate kinase type-1 family
E5491_RS13625	COG2814	Major facilitator Superfamily
E5491_RS13645	COG1113	amino acid transport
E5491_RS13660	COG0531	amino acid
E5491_RS13685	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E5491_RS13695	COG1174	glycine betaine transport
E5491_RS13705	COG1174	glycine betaine transport
E5491_RS13725	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
E5491_RS13730	COG0531	amino acid
E5491_RS13735	COG2272	Belongs to the type-B carboxylesterase lipase family
E5491_RS13740	COG2814	Major facilitator Superfamily
E5491_RS13745	COG0390	transport system, permease component
E5491_RS13750	COG4619	ABC transporter
E5491_RS13755	COG1363	Peptidase, m42
E5491_RS13775	COG4808	Protein conserved in bacteria
E5491_RS13780	COG0069	glutamate synthase activity
E5491_RS13835	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E5491_RS13840	COG1028	Short-chain dehydrogenase reductase Sdr
E5491_RS13845	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
E5491_RS13850	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E5491_RS13950	COG0494	nUDIX hydrolase
E5491_RS13995	COG1846	Transcriptional regulator
E5491_RS14030	COG1070	Carbohydrate kinase
E5491_RS14035	COG1802	Transcriptional regulator
E5491_RS14040	COG0789	Transcriptional regulator
E5491_RS14045	COG2357	RelA SpoT domain protein
E5491_RS14050	COG4876	unkown
E5491_RS14060	COG2271	Major facilitator Superfamily
E5491_RS14065	COG0586	Pfam SNARE associated Golgi protein
E5491_RS14085	COG1131	(ABC) transporter
E5491_RS14100	COG3949	Membrane
E5491_RS14105	COG0400	carboxylic ester hydrolase activity
E5491_RS14110	COG0346	lactoylglutathione lyase activity
E5491_RS14115	COG1846	Transcriptional regulator
E5491_RS14125	COG2514	catechol 2,3-dioxygenase activity
E5491_RS14140	COG0561	phosphatase activity
E5491_RS14145	COG1131	(ABC) transporter
E5491_RS14155	COG3764	Sortase (surface protein transpeptidase)
E5491_RS14175	COG1760	l-serine dehydratase
E5491_RS14180	COG1760	l-serine dehydratase
E5491_RS14195	COG0697	spore germination
E5491_RS14200	COG0657	acetylesterase activity
E5491_RS14220	COG0028	Belongs to the TPP enzyme family
E5491_RS14235	COG0583	DNA-binding transcription factor activity
E5491_RS14245	COG3942	CHAP domain
E5491_RS14255	COG3425	synthase
E5491_RS14260	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E5491_RS14285	COG2409	Drug exporters of the RND superfamily
E5491_RS14330	COG0436	Aminotransferase
E5491_RS14360	COG3942	CHAP domain
E5491_RS14365	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E5491_RS14365	COG2755	lipolytic protein G-D-S-L family
E5491_RS14475	COG3001	Fructosamine kinase
E5491_RS14480	COG0167	dihydroorotate dehydrogenase activity
E5491_RS14535	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E5491_RS14540	COG3527	Alpha-acetolactate decarboxylase
E5491_RS14555	COG0531	amino acid
E5491_RS14590	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5491_RS14610	COG1012	belongs to the aldehyde dehydrogenase family
E5491_RS14620	COG1510	regulation of RNA biosynthetic process
E5491_RS14625	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E5491_RS14650	COG2851	Citrate transporter
E5491_RS14665	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E5491_RS14675	COG0386	Belongs to the glutathione peroxidase family
E5491_RS14700	COG1136	(ABC) transporter
E5491_RS14705	COG2205	protein histidine kinase activity
E5491_RS14710	COG0745	RESPONSE REGULATOR receiver
E5491_RS14720	COG1785	Belongs to the alkaline phosphatase family
E5491_RS14730	COG1846	Transcriptional regulator
E5491_RS14775	COG1438	arginine binding
E5491_RS14795	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5491_RS14795	COG3711	transcriptional antiterminator
E5491_RS14800	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5491_RS14800	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E5491_RS14800	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E5491_RS14805	COG1482	cell wall glycoprotein biosynthetic process
E5491_RS14815	COG1705	Flagellar rod assembly protein muramidase FlgJ
E5491_RS14815	COG3942	CHAP domain
E5491_RS14820	COG1535	isochorismatase
E5491_RS14820	COG3433	isochorismatase activity
E5491_RS14835	COG0438	transferase activity, transferring glycosyl groups
E5491_RS14850	COG1073	alpha beta
E5491_RS14870	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E5491_RS14890	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E5491_RS14980	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E5491_RS15060	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E5491_RS15145	COG0471	metal ion transport
E5491_RS15150	COG2962	Rard protein
E5491_RS15160	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
E5491_RS15175	COG1136	(ABC) transporter
E5491_RS15180	COG0577	efflux transmembrane transporter activity
E5491_RS15190	COG1278	Cold shock
E5491_RS15215	COG1475	DNA binding