locus-tag	class	description
HTZ90_RS00015	COG2501	S4 domain
HTZ90_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HTZ90_RS00060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HTZ90_RS00070	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HTZ90_RS00080	COG0305	Participates in initiation and elongation during chromosome replication
HTZ90_RS00110	COG4863	YycH protein
HTZ90_RS00120	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HTZ90_RS00125	COG0737	Belongs to the 5'-nucleotidase family
HTZ90_RS00150	COG2826	transposase and inactivated derivatives, IS30 family
HTZ90_RS00160	COG1401	restriction endodeoxyribonuclease activity
HTZ90_RS00165	COG4268	DNA restriction-modification system
HTZ90_RS00190	COG2814	Major facilitator Superfamily
HTZ90_RS00210	COG0456	acetyltransferase
HTZ90_RS00245	COG0823	Involved in the tonB-independent uptake of proteins
HTZ90_RS00260	COG1473	amidohydrolase
HTZ90_RS00270	COG1283	sodium-dependent phosphate transmembrane transporter activity
HTZ90_RS00275	COG4716	Myosin-crossreactive antigen
HTZ90_RS00285	COG1620	l-lactate permease
HTZ90_RS00300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HTZ90_RS00305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HTZ90_RS00310	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HTZ90_RS00320	COG2423	ornithine cyclodeaminase activity
HTZ90_RS00325	COG4264	IucA IucC family
HTZ90_RS00330	COG2814	Major facilitator Superfamily
HTZ90_RS00335	COG4264	IucA IucC family
HTZ90_RS00340	COG4264	IucA IucC family
HTZ90_RS00350	COG0019	diaminopimelate decarboxylase activity
HTZ90_RS00355	COG1475	DNA binding
HTZ90_RS00375	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HTZ90_RS00380	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HTZ90_RS00385	COG0438	transferase activity, transferring glycosyl groups
HTZ90_RS00415	COG0813	purine-nucleoside phosphorylase activity
HTZ90_RS00420	COG2814	Major facilitator Superfamily
HTZ90_RS00440	COG3639	organic phosphonate transmembrane transporter activity
HTZ90_RS00460	COG0737	Belongs to the 5'-nucleotidase family
HTZ90_RS00475	COG1454	alcohol dehydrogenase
HTZ90_RS00475	COG1012	belongs to the aldehyde dehydrogenase family
HTZ90_RS00500	COG1086	Polysaccharide biosynthesis protein
HTZ90_RS00510	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HTZ90_RS00540	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HTZ90_RS00550	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HTZ90_RS00555	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HTZ90_RS00565	COG2832	Protein of unknown function (DUF454)
HTZ90_RS00600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HTZ90_RS00605	COG1960	acyl-CoA dehydrogenase activity
HTZ90_RS00610	COG5609	conserved protein (DUF2294)
HTZ90_RS00660	COG1114	Component of the transport system for branched-chain amino acids
HTZ90_RS00665	COG1335	isochorismatase
HTZ90_RS00670	COG3961	Belongs to the TPP enzyme family
HTZ90_RS00700	COG1737	Transcriptional regulator
HTZ90_RS00730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HTZ90_RS00740	COG0405	Gamma-glutamyltransferase
HTZ90_RS00755	COG3842	ATPase activity
HTZ90_RS00765	COG1175	transmembrane transport
HTZ90_RS00770	COG3833	ABC-type maltose transport systems, permease component
HTZ90_RS00775	COG0673	inositol 2-dehydrogenase activity
HTZ90_RS00780	COG0673	inositol 2-dehydrogenase activity
HTZ90_RS00790	COG1755	Isoprenylcysteine carboxyl methyltransferase
HTZ90_RS00850	COG0183	Belongs to the thiolase family
HTZ90_RS00860	COG1960	acyl-CoA dehydrogenase activity
HTZ90_RS00865	COG0318	PFAM AMP-dependent synthetase and ligase
HTZ90_RS00885	COG0747	negative chemotaxis
HTZ90_RS00890	COG3189	MarR family transcriptional regulator
HTZ90_RS00915	COG1263	PTS System
HTZ90_RS00915	COG2190	(PTS) system
HTZ90_RS00915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HTZ90_RS00920	COG1957	nucleoside hydrolase
HTZ90_RS00940	COG3414	Phosphotransferase system galactitol-specific IIB component
HTZ90_RS00945	COG3775	system Galactitol-specific IIC component
HTZ90_RS00950	COG1063	alcohol dehydrogenase
HTZ90_RS00960	COG1063	alcohol dehydrogenase
HTZ90_RS00970	COG1063	alcohol dehydrogenase
HTZ90_RS00975	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HTZ90_RS00980	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HTZ90_RS00990	COG1063	alcohol dehydrogenase
HTZ90_RS00995	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HTZ90_RS01035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HTZ90_RS01040	COG1263	PTS System
HTZ90_RS01040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HTZ90_RS01040	COG2190	(PTS) system
HTZ90_RS01045	COG2723	6-phospho-beta-galactosidase activity
HTZ90_RS01050	COG2226	methyltransferase
HTZ90_RS01105	COG1131	(ABC) transporter
HTZ90_RS01125	COG3942	CHAP domain
HTZ90_RS01125	COG1388	LysM domain
HTZ90_RS01235	COG1114	Component of the transport system for branched-chain amino acids
HTZ90_RS01240	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HTZ90_RS01245	COG0577	efflux transmembrane transporter activity
HTZ90_RS01270	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HTZ90_RS01275	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HTZ90_RS01325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HTZ90_RS01355	COG3037	sugar-specific permease SgaT UlaA
HTZ90_RS01365	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HTZ90_RS01370	COG3711	transcriptional antiterminator
HTZ90_RS01390	COG2271	Major facilitator Superfamily
HTZ90_RS01395	COG0346	lactoylglutathione lyase activity
HTZ90_RS01400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HTZ90_RS01415	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HTZ90_RS01420	COG2822	iron ion transport
HTZ90_RS01430	COG0672	)-iron permease
HTZ90_RS01435	COG0805	protein transport
HTZ90_RS01440	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HTZ90_RS01450	COG1476	TRANSCRIPTIONal
HTZ90_RS01460	COG1131	(ABC) transporter
HTZ90_RS01490	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HTZ90_RS01490	COG0646	methionine synthase
HTZ90_RS01495	COG0626	cystathionine gamma-synthase activity
HTZ90_RS01500	COG0626	cystathionine gamma-synthase activity
HTZ90_RS01505	COG1475	DNA binding
HTZ90_RS01510	COG0668	transmembrane transport
HTZ90_RS01515	COG4481	Protein conserved in bacteria
HTZ90_RS01520	COG0012	GTP binding
HTZ90_RS01630	COG5484	DNA packaging
HTZ90_RS01630	COG3728	DNA packaging
HTZ90_RS01720	COG1823	symporter activity
HTZ90_RS01750	COG2233	PERMEase
HTZ90_RS01785	COG3759	membrane
HTZ90_RS01920	COG0523	cobalamin synthesis protein
HTZ90_RS01945	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HTZ90_RS01955	COG5609	conserved protein (DUF2294)
HTZ90_RS01970	COG1647	Serine aminopeptidase, S33
HTZ90_RS01980	COG0733	neurotransmitter:sodium symporter activity
HTZ90_RS01985	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HTZ90_RS01990	COG0626	cystathionine gamma-synthase activity
HTZ90_RS02000	COG2011	ABC-type metal ion transport system permease component
HTZ90_RS02005	COG1464	Belongs to the NlpA lipoprotein family
HTZ90_RS02040	COG0583	DNA-binding transcription factor activity
HTZ90_RS02045	COG0070	glutamate synthase
HTZ90_RS02045	COG0069	glutamate synthase activity
HTZ90_RS02045	COG0067	glutamate synthase
HTZ90_RS02050	COG0493	'glutamate synthase
HTZ90_RS02060	COG1263	PTS System
HTZ90_RS02060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HTZ90_RS02065	COG0366	Alpha amylase catalytic
HTZ90_RS02070	COG2188	Transcriptional regulator
HTZ90_RS02090	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HTZ90_RS02125	COG1982	Orn Lys Arg decarboxylase major
HTZ90_RS02135	COG3870	Protein conserved in bacteria
HTZ90_RS02140	COG0470	DNA polymerase III
HTZ90_RS02145	COG1774	PSP1 C-terminal conserved region
HTZ90_RS02155	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HTZ90_RS02165	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HTZ90_RS02175	COG0084	hydrolase, TatD family'
HTZ90_RS02180	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HTZ90_RS02190	COG4466	Protein conserved in bacteria
HTZ90_RS02200	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HTZ90_RS02205	COG0251	oxidation-reduction process
HTZ90_RS02245	COG2244	polysaccharide biosynthetic process
HTZ90_RS02250	COG3956	TIGRFAM MazG family protein
HTZ90_RS02255	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HTZ90_RS02265	COG1098	S1 RNA binding domain
HTZ90_RS02280	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HTZ90_RS02305	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HTZ90_RS02385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HTZ90_RS02400	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HTZ90_RS02410	COG3880	PFAM UvrB UvrC protein
HTZ90_RS02425	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HTZ90_RS02430	COG4956	integral membrane protein (PIN domain superfamily)
HTZ90_RS02450	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HTZ90_RS02505	COG2813	Specifically methylates the guanine in position
HTZ90_RS02545	COG1473	amidohydrolase
HTZ90_RS02575	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HTZ90_RS02580	COG1428	Deoxynucleoside kinase
HTZ90_RS02585	COG1428	Deoxynucleoside kinase
HTZ90_RS02595	COG0561	phosphatase activity
HTZ90_RS02635	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HTZ90_RS02740	COG0095	Lipoate-protein ligase
HTZ90_RS02745	COG0083	homoserine kinase activity
HTZ90_RS02765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HTZ90_RS02805	COG0667	Aldo Keto reductase
HTZ90_RS02810	COG0655	NAD(P)H dehydrogenase (quinone) activity
HTZ90_RS02820	COG1078	dGTPase activity
HTZ90_RS02855	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HTZ90_RS02860	COG4139	cobalamin transport
HTZ90_RS02965	COG0803	Belongs to the bacterial solute-binding protein 9 family
HTZ90_RS02970	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HTZ90_RS02975	COG1121	(ABC) transporter
HTZ90_RS02980	COG1321	iron dependent repressor
HTZ90_RS03000	COG1682	transport, permease protein
HTZ90_RS03005	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HTZ90_RS03015	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HTZ90_RS03020	COG1686	Belongs to the peptidase S11 family
HTZ90_RS03025	COG1132	(ABC) transporter
HTZ90_RS03030	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HTZ90_RS03040	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HTZ90_RS03045	COG1120	ATPase activity
HTZ90_RS03050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HTZ90_RS03055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HTZ90_RS03060	COG2376	Dihydroxyacetone kinase
HTZ90_RS03080	COG3949	Membrane
HTZ90_RS03100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HTZ90_RS03115	COG1136	(ABC) transporter
HTZ90_RS03120	COG0577	efflux transmembrane transporter activity
HTZ90_RS03125	COG1392	Phosphate transport regulator
HTZ90_RS03130	COG0306	phosphate transporter
HTZ90_RS03135	COG1388	LysM domain
HTZ90_RS03135	COG3942	CHAP domain
HTZ90_RS03175	COG0583	DNA-binding transcription factor activity
HTZ90_RS03180	COG2814	Major facilitator Superfamily
HTZ90_RS03185	COG2839	Protein conserved in bacteria
HTZ90_RS03240	COG1136	(ABC) transporter
HTZ90_RS03240	COG0577	efflux transmembrane transporter activity
HTZ90_RS03315	COG0583	DNA-binding transcription factor activity
HTZ90_RS03395	COG1611	Belongs to the LOG family
HTZ90_RS03415	COG4988	ABC transporter
HTZ90_RS03420	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HTZ90_RS03430	COG0523	cobalamin synthesis protein
HTZ90_RS03435	COG4989	oxidoreductase activity
HTZ90_RS03445	COG2826	transposase and inactivated derivatives, IS30 family
HTZ90_RS03450	COG0471	metal ion transport
HTZ90_RS03485	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HTZ90_RS03490	COG1349	DNA-binding transcription factor activity
HTZ90_RS03495	COG1105	Belongs to the carbohydrate kinase PfkB family
HTZ90_RS03500	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HTZ90_RS03500	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HTZ90_RS03500	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HTZ90_RS03505	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HTZ90_RS03510	COG1253	flavin adenine dinucleotide binding
HTZ90_RS03515	COG0656	L-ascorbic acid biosynthetic process
HTZ90_RS03520	COG0463	Glycosyl transferase, family 2
HTZ90_RS03555	COG0720	synthase
HTZ90_RS03565	COG0512	Glutamine amidotransferase of anthranilate synthase
HTZ90_RS03565	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HTZ90_RS03570	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HTZ90_RS03600	COG0488	(ABC) transporter
HTZ90_RS03605	COG0514	ATP-dependent DNA helicase (RecQ)
HTZ90_RS03610	COG1125	glycine betaine transport
HTZ90_RS03610	COG0517	IMP dehydrogenase activity
HTZ90_RS03615	COG1174	glycine betaine transport
HTZ90_RS03640	COG3104	oligopeptide transport
HTZ90_RS03660	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HTZ90_RS03665	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HTZ90_RS03670	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HTZ90_RS03675	COG4605	iron ion homeostasis
HTZ90_RS03680	COG4604	ABC transporter, ATP-binding protein
HTZ90_RS03685	COG4607	ABC-type enterochelin transport system periplasmic component
HTZ90_RS03740	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HTZ90_RS03745	COG1739	Uncharacterized protein family UPF0029
HTZ90_RS03755	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HTZ90_RS03760	COG1040	competence protein
HTZ90_RS03785	COG3942	CHAP domain
HTZ90_RS03785	COG1388	LysM domain
HTZ90_RS03840	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HTZ90_RS03855	COG0281	malic enzyme
HTZ90_RS03905	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HTZ90_RS03910	COG1647	Serine aminopeptidase, S33
HTZ90_RS03915	COG0557	exoribonuclease II activity
HTZ90_RS03980	COG1278	Cold shock
HTZ90_RS04020	COG0406	alpha-ribazole phosphatase activity
HTZ90_RS04025	COG1279	arginine transmembrane transporter activity
HTZ90_RS04050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HTZ90_RS04055	COG1393	Belongs to the ArsC family
HTZ90_RS04065	COG3878	Protein conserved in bacteria
HTZ90_RS04085	COG2011	ABC-type metal ion transport system permease component
HTZ90_RS04090	COG1464	Belongs to the NlpA lipoprotein family
HTZ90_RS04105	COG0396	ATPase activity
HTZ90_RS04110	COG0719	Fe-S assembly protein
HTZ90_RS04120	COG0822	iron-sulfur transferase activity
HTZ90_RS04140	COG1253	flavin adenine dinucleotide binding
HTZ90_RS04150	COG1801	Protein of unknown function DUF72
HTZ90_RS04155	COG0730	response to heat
HTZ90_RS04170	COG4470	Protein conserved in bacteria
HTZ90_RS04180	COG2445	Protein of unknown function DUF86
HTZ90_RS04210	COG1696	Membrane protein involved in D-alanine export
HTZ90_RS04220	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HTZ90_RS04225	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HTZ90_RS04230	COG4837	Protein of unknown function (DUF1462)
HTZ90_RS04235	COG1252	NADH dehydrogenase
HTZ90_RS04245	COG0316	Belongs to the HesB IscA family
HTZ90_RS04255	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HTZ90_RS04260	COG2056	Na+-H+ antiporter family
HTZ90_RS04265	COG2050	protein possibly involved in aromatic compounds catabolism
HTZ90_RS04320	COG1098	S1 RNA binding domain
HTZ90_RS04325	COG1902	pentaerythritol trinitrate reductase activity
HTZ90_RS04340	COG0584	glycerophosphoryl diester phosphodiesterase
HTZ90_RS04360	COG0398	Pfam SNARE associated Golgi protein
HTZ90_RS04405	COG0561	phosphatase activity
HTZ90_RS04430	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HTZ90_RS04445	COG1881	PFAM PEBP family protein
HTZ90_RS04475	COG0601	transmembrane transport
HTZ90_RS04480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HTZ90_RS04485	COG0444	Belongs to the ABC transporter superfamily
HTZ90_RS04490	COG4608	Belongs to the ABC transporter superfamily
HTZ90_RS04495	COG4166	transmembrane transport
HTZ90_RS04505	COG2826	transposase and inactivated derivatives, IS30 family
HTZ90_RS04515	COG0444	Belongs to the ABC transporter superfamily
HTZ90_RS04520	COG4608	Belongs to the ABC transporter superfamily
HTZ90_RS04530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HTZ90_RS04565	COG1164	Oligoendopeptidase f
HTZ90_RS04575	COG2346	COG2346, Truncated hemoglobins
HTZ90_RS04590	COG2357	RelA SpoT domain protein
HTZ90_RS04600	COG0564	pseudouridine synthase activity
HTZ90_RS04605	COG2239	Acts as a magnesium transporter
HTZ90_RS04610	COG0569	domain protein
HTZ90_RS04610	COG0475	glutathione-regulated potassium exporter activity
HTZ90_RS04620	COG0628	permease
HTZ90_RS04625	COG1115	amino acid carrier protein
HTZ90_RS04675	COG0861	Integral membrane protein TerC family
HTZ90_RS04685	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HTZ90_RS04690	COG0737	Belongs to the 5'-nucleotidase family
HTZ90_RS04705	COG4903	ComK protein
HTZ90_RS04720	COG4873	Protein conserved in bacteria
HTZ90_RS04780	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HTZ90_RS04790	COG2314	TM2 domain
HTZ90_RS04795	COG0456	acetyltransferase
HTZ90_RS04800	COG1575	Belongs to the MenA family. Type 1 subfamily
HTZ90_RS04805	COG1169	isochorismate synthase
HTZ90_RS04815	COG2267	carboxylic ester hydrolase activity
HTZ90_RS04840	COG0436	Aminotransferase
HTZ90_RS04845	COG3594	Acyltransferase
HTZ90_RS04875	COG1316	TRANSCRIPTIONal
HTZ90_RS04920	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HTZ90_RS04935	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HTZ90_RS04975	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HTZ90_RS04980	COG4172	Belongs to the ABC transporter superfamily
HTZ90_RS04985	COG4721	ABC-type cobalt transport system, permease component
HTZ90_RS05000	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HTZ90_RS05025	COG1271	oxidase subunit
HTZ90_RS05030	COG1294	oxidase, subunit
HTZ90_RS05035	COG0569	domain protein
HTZ90_RS05100	COG1176	ABC-type spermidine putrescine transport system, permease component I
HTZ90_RS05105	COG1177	transmembrane transport
HTZ90_RS05110	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HTZ90_RS05135	COG0483	inositol monophosphate 1-phosphatase activity
HTZ90_RS05155	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HTZ90_RS05165	COG0772	Belongs to the SEDS family
HTZ90_RS05190	COG2340	Cysteine-rich secretory protein family
HTZ90_RS05195	COG3679	Belongs to the UPF0342 family
HTZ90_RS05200	COG0584	glycerophosphoryl diester phosphodiesterase
HTZ90_RS05215	COG0742	ribosomal rna small subunit methyltransferase
HTZ90_RS05270	COG4509	Sortase family
HTZ90_RS05285	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HTZ90_RS05315	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HTZ90_RS05315	COG1796	DNA polymerase
HTZ90_RS05340	COG2009	succinate dehydrogenase
HTZ90_RS05345	COG1053	succinate dehydrogenase
HTZ90_RS05350	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HTZ90_RS05460	COG1288	antiporter activity
HTZ90_RS05515	COG4839	cell division protein FtsL
HTZ90_RS05555	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HTZ90_RS05565	COG0762	integral membrane protein
HTZ90_RS05570	COG2302	S4 RNA-binding domain
HTZ90_RS05575	COG3599	regulation of cell shape
HTZ90_RS05590	COG2514	catechol 2,3-dioxygenase activity
HTZ90_RS05600	COG0564	pseudouridine synthase activity
HTZ90_RS05610	COG2233	PERMEase
HTZ90_RS05655	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HTZ90_RS05670	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HTZ90_RS05675	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HTZ90_RS05685	COG2314	TM2 domain
HTZ90_RS05700	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HTZ90_RS05700	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HTZ90_RS05710	COG0631	protein serine/threonine phosphatase activity
HTZ90_RS05725	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HTZ90_RS05740	COG1302	Protein conserved in bacteria
HTZ90_RS05785	COG1196	nuclear chromosome segregation
HTZ90_RS05790	COG0552	protein localization to endoplasmic reticulum
HTZ90_RS05800	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HTZ90_RS05855	COG2348	transferase activity, transferring amino-acyl groups
HTZ90_RS05860	COG0758	DNA mediated transformation
HTZ90_RS05955	COG0195	Participates in both transcription termination and antitermination
HTZ90_RS05960	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HTZ90_RS05985	COG0196	riboflavin kinase activity
HTZ90_RS06010	COG2188	Transcriptional regulator
HTZ90_RS06015	COG0612	Peptidase, M16
HTZ90_RS06020	COG0612	Peptidase, M16
HTZ90_RS06025	COG0300	oxidoreductase activity
HTZ90_RS06045	COG1058	Belongs to the CinA family
HTZ90_RS06045	COG1546	Belongs to the CinA family
HTZ90_RS06065	COG1692	metallophosphoesterase
HTZ90_RS06070	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HTZ90_RS06070	COG0674	pyruvate-flavodoxin oxidoreductase activity
HTZ90_RS06075	COG1013	pyruvate-flavodoxin oxidoreductase activity
HTZ90_RS06110	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HTZ90_RS06115	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HTZ90_RS06140	COG1923	regulation of RNA biosynthetic process
HTZ90_RS06155	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HTZ90_RS06160	COG0789	Transcriptional regulator
HTZ90_RS06175	COG2826	transposase and inactivated derivatives, IS30 family
HTZ90_RS06205	COG1674	ftsk spoiiie
HTZ90_RS06210	COG0433	COG0433 Predicted ATPase
HTZ90_RS06230	COG2946	Replication initiation factor
HTZ90_RS06375	COG1131	(ABC) transporter
HTZ90_RS06390	COG2197	response regulator
HTZ90_RS06400	COG1525	nuclease
HTZ90_RS06415	COG0527	aspartate kinase activity
HTZ90_RS06420	COG0460	homoserine dehydrogenase
HTZ90_RS06425	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HTZ90_RS06450	COG0833	amino acid
HTZ90_RS06510	COG4846	Membrane protein involved in cytochrome C biogenesis
HTZ90_RS06530	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HTZ90_RS06540	COG0824	Thioesterase
HTZ90_RS06565	COG1115	amino acid carrier protein
HTZ90_RS06580	COG0628	permease
HTZ90_RS06610	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HTZ90_RS06620	COG1363	Peptidase, m42
HTZ90_RS06625	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HTZ90_RS06630	COG0512	Glutamine amidotransferase of anthranilate synthase
HTZ90_RS06715	COG0704	Plays a role in the regulation of phosphate uptake
HTZ90_RS06725	COG0581	inorganic phosphate transmembrane transporter activity
HTZ90_RS06730	COG0573	inorganic phosphate transmembrane transporter activity
HTZ90_RS06745	COG0488	(ABC) transporter
HTZ90_RS06750	COG0527	aspartate kinase activity
HTZ90_RS06755	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HTZ90_RS06825	COG4548	von Willebrand factor, type A
HTZ90_RS06830	COG0714	Associated with various cellular activities
HTZ90_RS06875	COG0671	phosphoesterase, PA-phosphatase related
HTZ90_RS06895	COG2826	transposase and inactivated derivatives, IS30 family
HTZ90_RS06955	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HTZ90_RS06975	COG0531	amino acid
HTZ90_RS06990	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HTZ90_RS06995	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HTZ90_RS07010	COG0116	Belongs to the methyltransferase superfamily
HTZ90_RS07040	COG4499	WXG100 protein secretion system (Wss), protein YukC
HTZ90_RS07040	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HTZ90_RS07050	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HTZ90_RS07055	COG3935	DnaD domain protein
HTZ90_RS07080	COG0438	transferase activity, transferring glycosyl groups
HTZ90_RS07085	COG1694	Mazg nucleotide pyrophosphohydrolase
HTZ90_RS07090	COG2738	Putative neutral zinc metallopeptidase
HTZ90_RS07095	COG4347	Protein of unknown function (DUF1405)
HTZ90_RS07130	COG0142	geranyltranstransferase activity
HTZ90_RS07185	COG0492	ferredoxin-NADP+ reductase activity
HTZ90_RS07200	COG0514	ATP-dependent DNA helicase (RecQ)
HTZ90_RS07210	COG1141	Ferredoxin
HTZ90_RS07240	COG0860	N-Acetylmuramoyl-L-alanine amidase
HTZ90_RS07240	COG1388	LysM domain
HTZ90_RS07290	COG3953	SLT domain
HTZ90_RS07290	COG5280	Phage tail tape measure protein TP901
HTZ90_RS07520	COG2176	DNA-directed DNA polymerase activity
HTZ90_RS07540	COG0582	viral genome integration into host DNA
HTZ90_RS07560	COG0745	RESPONSE REGULATOR receiver
HTZ90_RS07565	COG1187	pseudouridine synthase activity
HTZ90_RS07590	COG0735	belongs to the Fur family
HTZ90_RS07595	COG0494	nUDIX hydrolase
HTZ90_RS07600	COG0667	Aldo Keto reductase
HTZ90_RS07610	COG4221	oxidoreductase activity
HTZ90_RS07625	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HTZ90_RS07635	COG0366	Alpha amylase catalytic
HTZ90_RS07640	COG1609	Transcriptional regulator
HTZ90_RS07675	COG2195	Cleaves the N-terminal amino acid of tripeptides
HTZ90_RS07685	COG4129	membrane
HTZ90_RS07695	COG0508	dehydrogenase complex catalyzes the overall conversion of
HTZ90_RS07700	COG0022	dehydrogenase e1 component
HTZ90_RS07705	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HTZ90_RS07710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HTZ90_RS07715	COG0497	DNA recombination
HTZ90_RS07745	COG1302	Protein conserved in bacteria
HTZ90_RS07750	COG0439	Biotin carboxylase
HTZ90_RS07755	COG0511	ligase activity, forming carbon-carbon bonds
HTZ90_RS07765	COG0006	proline dipeptidase activity
HTZ90_RS07780	COG0095	Lipoate-protein ligase
HTZ90_RS07785	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HTZ90_RS07830	COG4537	Required for transformation and DNA binding
HTZ90_RS07835	COG1459	type II secretion system
HTZ90_RS07840	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HTZ90_RS07845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HTZ90_RS07850	COG0011	TIGRFAM Protein of
HTZ90_RS07855	COG1940	carbohydrate kinase activity
HTZ90_RS07860	COG4483	Protein conserved in bacteria
HTZ90_RS07870	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HTZ90_RS07895	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HTZ90_RS07900	COG1121	(ABC) transporter
HTZ90_RS07910	COG0513	Belongs to the DEAD box helicase family
HTZ90_RS07920	COG2384	SAM-dependent methyltransferase
HTZ90_RS07940	COG0517	IMP dehydrogenase activity
HTZ90_RS07960	COG0295	cytidine deaminase activity
HTZ90_RS07975	COG1702	phosphate starvation-inducible protein PhoH
HTZ90_RS07990	COG1030	water channel activity
HTZ90_RS08000	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HTZ90_RS08005	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HTZ90_RS08035	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HTZ90_RS08050	COG1466	dna polymerase III delta subunit
HTZ90_RS08055	COG0658	competence protein
HTZ90_RS08055	COG2333	competence protein COMEC
HTZ90_RS08060	COG2131	deaminase
HTZ90_RS08070	COG2226	methyltransferase
HTZ90_RS08075	COG0799	negative regulation of ribosome biogenesis
HTZ90_RS08080	COG1713	HD superfamily hydrolase involved in NAD metabolism
HTZ90_RS08090	COG1534	Rna-binding protein
HTZ90_RS08100	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HTZ90_RS08105	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HTZ90_RS08130	COG1914	H( )-stimulated, divalent metal cation uptake system
HTZ90_RS08145	COG0511	ligase activity, forming carbon-carbon bonds
HTZ90_RS08150	COG1984	allophanate hydrolase subunit 2
HTZ90_RS08155	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HTZ90_RS08205	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HTZ90_RS08220	COG1104	cysteine desulfurase activity
HTZ90_RS08225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HTZ90_RS08235	COG3237	CsbD-like
HTZ90_RS08240	COG1959	2 iron, 2 sulfur cluster binding
HTZ90_RS08245	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HTZ90_RS08250	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HTZ90_RS08295	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HTZ90_RS08295	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HTZ90_RS08300	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HTZ90_RS08300	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HTZ90_RS08305	COG1862	Preprotein translocase
HTZ90_RS08345	COG2868	ribosomal protein
HTZ90_RS08390	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HTZ90_RS08395	COG0285	dihydrofolate synthase activity
HTZ90_RS08405	COG2818	Glycosylase
HTZ90_RS08440	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HTZ90_RS08475	COG4112	unkown
HTZ90_RS08495	COG0833	amino acid
HTZ90_RS08510	COG1484	DNA-dependent DNA replication
HTZ90_RS08540	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HTZ90_RS08540	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HTZ90_RS08550	COG5002	protein histidine kinase activity
HTZ90_RS08555	COG0745	RESPONSE REGULATOR receiver
HTZ90_RS08565	COG0372	Belongs to the citrate synthase family
HTZ90_RS08570	COG1113	amino acid transport
HTZ90_RS08595	COG0281	malic enzyme
HTZ90_RS08605	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HTZ90_RS08610	COG4109	DRTGG domain
HTZ90_RS08650	COG0827	DNA restriction-modification system
HTZ90_RS08660	COG0730	response to heat
HTZ90_RS08670	COG1104	cysteine desulfurase activity
HTZ90_RS08685	COG1956	GAF domain-containing protein
HTZ90_RS08695	COG0584	glycerophosphoryl diester phosphodiesterase
HTZ90_RS08700	COG1764	response to oxidative stress
HTZ90_RS08705	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HTZ90_RS08710	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HTZ90_RS08725	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HTZ90_RS08725	COG1263	PTS System
HTZ90_RS08730	COG0204	Acyl-transferase
HTZ90_RS08735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HTZ90_RS08765	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HTZ90_RS08790	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HTZ90_RS08790	COG1605	Chorismate mutase
HTZ90_RS08815	COG1674	ftsk spoiiie
HTZ90_RS08820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HTZ90_RS08830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HTZ90_RS08835	COG1363	Peptidase, m42
HTZ90_RS08845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HTZ90_RS08865	COG3682	Transcriptional regulator
HTZ90_RS08885	COG0510	thiamine kinase activity
HTZ90_RS08905	COG1187	pseudouridine synthase activity
HTZ90_RS08910	COG2244	polysaccharide biosynthetic process
HTZ90_RS08915	COG2081	HI0933 family
HTZ90_RS08935	COG2814	Major facilitator Superfamily
HTZ90_RS08940	COG1242	4 iron, 4 sulfur cluster binding
HTZ90_RS08945	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HTZ90_RS08955	COG2267	carboxylic ester hydrolase activity
HTZ90_RS08985	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HTZ90_RS08985	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HTZ90_RS09005	COG5632	N-Acetylmuramoyl-L-alanine amidase
HTZ90_RS09005	COG4193	domain, Protein
HTZ90_RS09005	COG3266	domain, Protein
HTZ90_RS09040	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HTZ90_RS09060	COG0656	L-ascorbic acid biosynthetic process
HTZ90_RS09080	COG1506	peptidase
HTZ90_RS09085	COG2816	NAD+ diphosphatase activity
HTZ90_RS09175	COG5492	domain, Protein
HTZ90_RS09385	COG1131	(ABC) transporter
HTZ90_RS09390	COG0537	adenosine 5'-monophosphoramidase activity
HTZ90_RS09420	COG0420	3'-5' exonuclease activity
HTZ90_RS09440	COG2197	response regulator
HTZ90_RS09445	COG2203	Gaf domain
HTZ90_RS09445	COG4585	Histidine kinase
HTZ90_RS09450	COG0564	pseudouridine synthase activity
HTZ90_RS09480	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HTZ90_RS09485	COG1126	abc transporter atp-binding protein
HTZ90_RS09490	COG0765	amino acid transport
HTZ90_RS09660	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HTZ90_RS09670	COG4129	membrane
HTZ90_RS09685	COG1194	a g-specific adenine glycosylase
HTZ90_RS09690	COG1988	membrane-bound metal-dependent
HTZ90_RS09700	COG1134	teichoic acid transport
HTZ90_RS09700	COG1388	LysM domain
HTZ90_RS09730	COG0535	radical SAM domain protein
HTZ90_RS09735	COG1607	acyl-coa hydrolase
HTZ90_RS09740	COG2309	aminopeptidase activity
HTZ90_RS09760	COG1295	ribonuclease BN
HTZ90_RS09875	COG4851	CamS sex pheromone cAM373 precursor
HTZ90_RS09895	COG4496	protein, YerC YecD
HTZ90_RS09930	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HTZ90_RS09940	COG0077	Prephenate dehydratase
HTZ90_RS09960	COG1335	isochorismatase
HTZ90_RS09975	COG1012	belongs to the aldehyde dehydrogenase family
HTZ90_RS10025	COG1131	(ABC) transporter
HTZ90_RS10040	COG1725	Transcriptional regulator
HTZ90_RS10105	COG1388	LysM domain
HTZ90_RS10105	COG5632	N-Acetylmuramoyl-L-alanine amidase
HTZ90_RS10155	COG0739	heme binding
HTZ90_RS10210	COG0740	serine-type endopeptidase activity
HTZ90_RS10390	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HTZ90_RS10440	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HTZ90_RS10475	COG3728	DNA packaging
HTZ90_RS10475	COG5484	DNA packaging
HTZ90_RS10560	COG0582	viral genome integration into host DNA
HTZ90_RS10620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HTZ90_RS10625	COG1621	beta-fructofuranosidase activity
HTZ90_RS10630	COG1609	Transcriptional regulator
HTZ90_RS10635	COG0004	ammonium transporteR
HTZ90_RS10640	COG0425	Belongs to the sulfur carrier protein TusA family
HTZ90_RS10645	COG2391	methyltransferase activity
HTZ90_RS10655	COG0488	(ABC) transporter
HTZ90_RS10665	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HTZ90_RS10675	COG0456	acetyltransferase
HTZ90_RS10680	COG1214	PFAM Peptidase M22, glycoprotease
HTZ90_RS10685	COG0802	atpase or kinase
HTZ90_RS10700	COG0028	Belongs to the TPP enzyme family
HTZ90_RS10775	COG2183	response to ionizing radiation
HTZ90_RS10780	COG1191	sigma factor activity
HTZ90_RS10790	COG1366	Belongs to the anti-sigma-factor antagonist family
HTZ90_RS10795	COG2208	phosphoserine phosphatase activity
HTZ90_RS10825	COG3428	Bacterial PH domain
HTZ90_RS10855	COG2205	protein histidine kinase activity
HTZ90_RS10860	COG0745	RESPONSE REGULATOR receiver
HTZ90_RS10870	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HTZ90_RS10880	COG0772	Belongs to the SEDS family
HTZ90_RS10900	COG1937	Protein conserved in bacteria
HTZ90_RS10910	COG1418	mRNA catabolic process
HTZ90_RS10945	COG0629	single-stranded DNA binding
HTZ90_RS11020	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HTZ90_RS11045	COG0009	L-threonylcarbamoyladenylate synthase
HTZ90_RS11050	COG2890	protein-(glutamine-N5) methyltransferase activity
HTZ90_RS11070	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HTZ90_RS11110	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HTZ90_RS11155	COG0813	purine-nucleoside phosphorylase activity
HTZ90_RS11160	COG0783	Belongs to the Dps family
HTZ90_RS11180	COG1482	cell wall glycoprotein biosynthetic process
HTZ90_RS11185	COG0702	epimerase
HTZ90_RS11190	COG0640	Transcriptional regulator
HTZ90_RS11220	COG0561	phosphatase activity
HTZ90_RS11225	COG1119	ATPase activity
HTZ90_RS11240	COG3711	transcriptional antiterminator
HTZ90_RS11270	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HTZ90_RS11330	COG0489	protein tyrosine kinase activity
HTZ90_RS11350	COG1272	protein, Hemolysin III
HTZ90_RS11360	COG1988	membrane-bound metal-dependent
HTZ90_RS11375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HTZ90_RS11380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HTZ90_RS11385	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HTZ90_RS11395	COG3457	Alanine racemase
HTZ90_RS11400	COG4264	IucA IucC family
HTZ90_RS11405	COG2814	Major facilitator Superfamily
HTZ90_RS11430	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HTZ90_RS11440	COG2130	NADP-dependent
HTZ90_RS11515	COG0656	L-ascorbic acid biosynthetic process
HTZ90_RS11520	COG0789	Transcriptional regulator
HTZ90_RS11530	COG5492	domain, Protein
HTZ90_RS11550	COG3527	Alpha-acetolactate decarboxylase
HTZ90_RS11555	COG0028	Belongs to the TPP enzyme family
HTZ90_RS11650	COG0201	protein transport
HTZ90_RS11765	COG2252	PERMEase
HTZ90_RS11810	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HTZ90_RS11870	COG1763	Mo-molybdopterin cofactor biosynthetic process
HTZ90_RS11890	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HTZ90_RS11895	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HTZ90_RS11900	COG4149	molybdate abc transporter
HTZ90_RS11905	COG0725	ABC transporter, periplasmic molybdate-binding protein
HTZ90_RS11920	COG1268	BioY protein
HTZ90_RS11935	COG1960	acyl-CoA dehydrogenase activity
HTZ90_RS11940	COG4413	Urea transporter
HTZ90_RS12010	COG1757	Na H antiporter
HTZ90_RS12025	COG3942	CHAP domain
HTZ90_RS12090	COG1113	amino acid transport
HTZ90_RS12110	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HTZ90_RS12125	COG1263	PTS System
HTZ90_RS12125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HTZ90_RS12130	COG1737	Transcriptional regulator
HTZ90_RS12150	COG1028	Short-chain dehydrogenase reductase Sdr
HTZ90_RS12170	COG0583	DNA-binding transcription factor activity
HTZ90_RS12195	COG2258	MOSC domain
HTZ90_RS12215	COG1668	transmembrane transport
HTZ90_RS12220	COG4152	abc transporter atp-binding protein
HTZ90_RS12235	COG0786	glutamate:sodium symporter activity
HTZ90_RS12245	COG0598	Magnesium transport protein CorA
HTZ90_RS12260	COG0657	acetylesterase activity
HTZ90_RS12270	COG2814	Major facilitator Superfamily
HTZ90_RS12275	COG1566	PFAM secretion protein HlyD family protein
HTZ90_RS12290	COG2814	Major facilitator Superfamily
HTZ90_RS12350	COG1131	(ABC) transporter
HTZ90_RS12365	COG1620	l-lactate permease
HTZ90_RS12385	COG0604	alcohol dehydrogenase
HTZ90_RS12415	COG1511	domain protein
HTZ90_RS12430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HTZ90_RS12430	COG1263	PTS System
HTZ90_RS12445	COG3871	stress protein (general stress protein 26)
HTZ90_RS12510	COG2181	nitrate reductase activity
HTZ90_RS12520	COG1140	nitrate reductase beta subunit
HTZ90_RS12525	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HTZ90_RS12535	COG2146	nitrite reductase [NAD(P)H] activity
HTZ90_RS12540	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HTZ90_RS12550	COG0454	-acetyltransferase
HTZ90_RS12555	COG2116	formate transmembrane transporter activity
HTZ90_RS12570	COG3443	Belongs to the bacterial solute-binding protein 9 family
HTZ90_RS12570	COG0803	Belongs to the bacterial solute-binding protein 9 family
HTZ90_RS12605	COG1126	abc transporter atp-binding protein
HTZ90_RS12610	COG0765	amino acid transport
HTZ90_RS12615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HTZ90_RS12620	COG2814	Major facilitator Superfamily
HTZ90_RS12635	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HTZ90_RS12675	COG0156	8-amino-7-oxononanoate synthase activity
HTZ90_RS12685	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HTZ90_RS12690	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HTZ90_RS12700	COG1132	(ABC) transporter
HTZ90_RS12720	COG1929	Belongs to the glycerate kinase type-1 family
HTZ90_RS12730	COG2814	Major facilitator Superfamily
HTZ90_RS12750	COG1113	amino acid transport
HTZ90_RS12760	COG0531	amino acid
HTZ90_RS12775	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HTZ90_RS12785	COG1174	glycine betaine transport
HTZ90_RS12795	COG1174	glycine betaine transport
HTZ90_RS12815	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
HTZ90_RS12820	COG0531	amino acid
HTZ90_RS12825	COG2272	Belongs to the type-B carboxylesterase lipase family
HTZ90_RS12830	COG2814	Major facilitator Superfamily
HTZ90_RS12835	COG0390	transport system, permease component
HTZ90_RS12840	COG4619	ABC transporter
HTZ90_RS12845	COG1363	Peptidase, m42
HTZ90_RS12850	COG4808	Protein conserved in bacteria
HTZ90_RS12855	COG0069	glutamate synthase activity
HTZ90_RS12870	COG1124	(ABC) transporter
HTZ90_RS12880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HTZ90_RS12885	COG0601	transmembrane transport
HTZ90_RS12890	COG0747	negative chemotaxis
HTZ90_RS12910	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HTZ90_RS12915	COG1028	Short-chain dehydrogenase reductase Sdr
HTZ90_RS12920	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HTZ90_RS12925	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HTZ90_RS13000	COG0494	nUDIX hydrolase
HTZ90_RS13040	COG1070	Carbohydrate kinase
HTZ90_RS13045	COG1802	Transcriptional regulator
HTZ90_RS13050	COG0789	Transcriptional regulator
HTZ90_RS13055	COG2357	RelA SpoT domain protein
HTZ90_RS13060	COG4876	unkown
HTZ90_RS13070	COG2271	Major facilitator Superfamily
HTZ90_RS13075	COG0586	Pfam SNARE associated Golgi protein
HTZ90_RS13080	COG1279	arginine transmembrane transporter activity
HTZ90_RS13090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HTZ90_RS13095	COG1131	(ABC) transporter
HTZ90_RS13110	COG3949	Membrane
HTZ90_RS13115	COG0400	carboxylic ester hydrolase activity
HTZ90_RS13120	COG0346	lactoylglutathione lyase activity
HTZ90_RS13125	COG1846	Transcriptional regulator
HTZ90_RS13135	COG2514	catechol 2,3-dioxygenase activity
HTZ90_RS13155	COG0561	phosphatase activity
HTZ90_RS13160	COG3764	Sortase (surface protein transpeptidase)
HTZ90_RS13180	COG1760	l-serine dehydratase
HTZ90_RS13185	COG1760	l-serine dehydratase
HTZ90_RS13200	COG0697	spore germination
HTZ90_RS13205	COG0657	acetylesterase activity
HTZ90_RS13225	COG0028	Belongs to the TPP enzyme family
HTZ90_RS13240	COG0583	DNA-binding transcription factor activity
HTZ90_RS13250	COG3942	CHAP domain
HTZ90_RS13260	COG3425	synthase
HTZ90_RS13265	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HTZ90_RS13290	COG2409	Drug exporters of the RND superfamily
HTZ90_RS13335	COG0436	Aminotransferase
HTZ90_RS13470	COG3001	Fructosamine kinase
HTZ90_RS13475	COG0167	dihydroorotate dehydrogenase activity
HTZ90_RS13525	COG3527	Alpha-acetolactate decarboxylase
HTZ90_RS13535	COG0531	amino acid
HTZ90_RS13565	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HTZ90_RS13585	COG1012	belongs to the aldehyde dehydrogenase family
HTZ90_RS13595	COG1510	regulation of RNA biosynthetic process
HTZ90_RS13600	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HTZ90_RS13625	COG2851	Citrate transporter
HTZ90_RS13640	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HTZ90_RS13650	COG0386	Belongs to the glutathione peroxidase family
HTZ90_RS13670	COG1136	(ABC) transporter
HTZ90_RS13675	COG2205	protein histidine kinase activity
HTZ90_RS13680	COG0745	RESPONSE REGULATOR receiver
HTZ90_RS13690	COG1785	Belongs to the alkaline phosphatase family
HTZ90_RS13700	COG1846	Transcriptional regulator
HTZ90_RS13745	COG1438	arginine binding
HTZ90_RS13765	COG3711	transcriptional antiterminator
HTZ90_RS13765	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HTZ90_RS13770	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HTZ90_RS13770	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HTZ90_RS13770	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HTZ90_RS13775	COG1482	cell wall glycoprotein biosynthetic process
HTZ90_RS13785	COG3942	CHAP domain
HTZ90_RS13785	COG1705	Flagellar rod assembly protein muramidase FlgJ
HTZ90_RS13790	COG3433	isochorismatase activity
HTZ90_RS13790	COG1535	isochorismatase
HTZ90_RS13805	COG0438	transferase activity, transferring glycosyl groups
HTZ90_RS13820	COG1073	alpha beta
HTZ90_RS13840	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HTZ90_RS13860	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HTZ90_RS13945	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HTZ90_RS14025	COG0471	metal ion transport
HTZ90_RS14030	COG2962	Rard protein
HTZ90_RS14040	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HTZ90_RS14055	COG1136	(ABC) transporter
HTZ90_RS14060	COG0577	efflux transmembrane transporter activity
HTZ90_RS14085	COG1404	Belongs to the peptidase S8 family
HTZ90_RS14090	COG1278	Cold shock
HTZ90_RS14110	COG1475	DNA binding