locus-tag	class	description
B4602_RS00015	COG2501	S4 domain
B4602_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B4602_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B4602_RS00065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B4602_RS00075	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
B4602_RS00085	COG0305	Participates in initiation and elongation during chromosome replication
B4602_RS00120	COG4863	YycH protein
B4602_RS00130	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B4602_RS00135	COG0737	Belongs to the 5'-nucleotidase family
B4602_RS00155	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
B4602_RS00165	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
B4602_RS00190	COG0730	response to heat
B4602_RS00195	COG1937	Protein conserved in bacteria
B4602_RS00200	COG2210	Belongs to the sulfur carrier protein TusA family
B4602_RS00205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4602_RS00255	COG0823	Involved in the tonB-independent uptake of proteins
B4602_RS00300	COG1473	amidohydrolase
B4602_RS00315	COG1283	sodium-dependent phosphate transmembrane transporter activity
B4602_RS00320	COG4716	Myosin-crossreactive antigen
B4602_RS00325	COG0697	spore germination
B4602_RS00340	COG1620	l-lactate permease
B4602_RS00360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4602_RS00365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4602_RS00370	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B4602_RS00380	COG2423	ornithine cyclodeaminase activity
B4602_RS00385	COG4264	IucA IucC family
B4602_RS00390	COG2814	Major facilitator Superfamily
B4602_RS00395	COG4264	IucA IucC family
B4602_RS00400	COG4264	IucA IucC family
B4602_RS00410	COG0019	diaminopimelate decarboxylase activity
B4602_RS00415	COG1475	DNA binding
B4602_RS00445	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B4602_RS00450	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B4602_RS00455	COG0438	transferase activity, transferring glycosyl groups
B4602_RS00485	COG0813	purine-nucleoside phosphorylase activity
B4602_RS00490	COG2814	Major facilitator Superfamily
B4602_RS00510	COG3639	organic phosphonate transmembrane transporter activity
B4602_RS00530	COG0737	Belongs to the 5'-nucleotidase family
B4602_RS00545	COG1012	belongs to the aldehyde dehydrogenase family
B4602_RS00545	COG1454	alcohol dehydrogenase
B4602_RS00570	COG1086	Polysaccharide biosynthesis protein
B4602_RS00580	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B4602_RS00610	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B4602_RS00620	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
B4602_RS00625	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B4602_RS00635	COG2832	Protein of unknown function (DUF454)
B4602_RS00675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B4602_RS00680	COG1960	acyl-CoA dehydrogenase activity
B4602_RS00685	COG5609	conserved protein (DUF2294)
B4602_RS00735	COG1114	Component of the transport system for branched-chain amino acids
B4602_RS00740	COG1335	isochorismatase
B4602_RS00745	COG3961	Belongs to the TPP enzyme family
B4602_RS00775	COG1737	Transcriptional regulator
B4602_RS00800	COG1136	(ABC) transporter
B4602_RS00805	COG0577	efflux transmembrane transporter activity
B4602_RS00805	COG1136	(ABC) transporter
B4602_RS00825	COG1131	(ABC) transporter
B4602_RS00840	COG0601	transmembrane transport
B4602_RS00845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B4602_RS00855	COG0405	Gamma-glutamyltransferase
B4602_RS00875	COG3842	ATPase activity
B4602_RS00885	COG1175	transmembrane transport
B4602_RS00890	COG3833	ABC-type maltose transport systems, permease component
B4602_RS00895	COG0673	inositol 2-dehydrogenase activity
B4602_RS00900	COG0673	inositol 2-dehydrogenase activity
B4602_RS00910	COG1755	Isoprenylcysteine carboxyl methyltransferase
B4602_RS00970	COG0183	Belongs to the thiolase family
B4602_RS00980	COG1960	acyl-CoA dehydrogenase activity
B4602_RS00985	COG0318	PFAM AMP-dependent synthetase and ligase
B4602_RS01000	COG0747	negative chemotaxis
B4602_RS01005	COG3189	MarR family transcriptional regulator
B4602_RS01035	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4602_RS01035	COG1263	PTS System
B4602_RS01035	COG2190	(PTS) system
B4602_RS01040	COG1957	nucleoside hydrolase
B4602_RS01060	COG3414	Phosphotransferase system galactitol-specific IIB component
B4602_RS01065	COG3775	system Galactitol-specific IIC component
B4602_RS01070	COG1063	alcohol dehydrogenase
B4602_RS01080	COG1063	alcohol dehydrogenase
B4602_RS01090	COG1063	alcohol dehydrogenase
B4602_RS01095	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B4602_RS01100	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B4602_RS01110	COG1063	alcohol dehydrogenase
B4602_RS01115	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B4602_RS01150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4602_RS01160	COG1263	PTS System
B4602_RS01160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4602_RS01160	COG2190	(PTS) system
B4602_RS01165	COG2723	6-phospho-beta-galactosidase activity
B4602_RS01175	COG2226	methyltransferase
B4602_RS01225	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
B4602_RS01260	COG3942	CHAP domain
B4602_RS01260	COG1388	LysM domain
B4602_RS01395	COG1114	Component of the transport system for branched-chain amino acids
B4602_RS01405	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
B4602_RS01415	COG0577	efflux transmembrane transporter activity
B4602_RS01445	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B4602_RS01450	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B4602_RS01475	COG3314	Sporulation integral membrane protein YlbJ
B4602_RS01500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4602_RS01525	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B4602_RS01530	COG3037	sugar-specific permease SgaT UlaA
B4602_RS01540	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4602_RS01545	COG3711	transcriptional antiterminator
B4602_RS01570	COG2271	Major facilitator Superfamily
B4602_RS01575	COG0346	lactoylglutathione lyase activity
B4602_RS01580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4602_RS01585	COG0431	NADPH-dependent FMN reductase
B4602_RS01600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4602_RS01605	COG2822	iron ion transport
B4602_RS01615	COG0672	)-iron permease
B4602_RS01620	COG0805	protein transport
B4602_RS01625	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B4602_RS01635	COG1476	TRANSCRIPTIONal
B4602_RS01645	COG1131	(ABC) transporter
B4602_RS01675	COG0646	methionine synthase
B4602_RS01675	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B4602_RS01680	COG0626	cystathionine gamma-synthase activity
B4602_RS01685	COG0626	cystathionine gamma-synthase activity
B4602_RS01695	COG1475	DNA binding
B4602_RS01700	COG0668	transmembrane transport
B4602_RS01705	COG4481	Protein conserved in bacteria
B4602_RS01710	COG0012	GTP binding
B4602_RS01820	COG1823	symporter activity
B4602_RS01855	COG2233	PERMEase
B4602_RS01905	COG1683	Conserved Protein
B4602_RS01910	COG3759	membrane
B4602_RS02080	COG0523	cobalamin synthesis protein
B4602_RS02095	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B4602_RS02105	COG5609	conserved protein (DUF2294)
B4602_RS02120	COG1647	Serine aminopeptidase, S33
B4602_RS02130	COG0733	neurotransmitter:sodium symporter activity
B4602_RS02135	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B4602_RS02140	COG0626	cystathionine gamma-synthase activity
B4602_RS02150	COG2011	ABC-type metal ion transport system permease component
B4602_RS02155	COG1464	Belongs to the NlpA lipoprotein family
B4602_RS02190	COG0583	DNA-binding transcription factor activity
B4602_RS02195	COG0069	glutamate synthase activity
B4602_RS02195	COG0070	glutamate synthase
B4602_RS02195	COG0067	glutamate synthase
B4602_RS02200	COG0493	'glutamate synthase
B4602_RS02210	COG1263	PTS System
B4602_RS02210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4602_RS02215	COG0366	Alpha amylase catalytic
B4602_RS02220	COG2188	Transcriptional regulator
B4602_RS02240	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B4602_RS02280	COG1982	Orn Lys Arg decarboxylase major
B4602_RS02290	COG3870	Protein conserved in bacteria
B4602_RS02295	COG0470	DNA polymerase III
B4602_RS02300	COG1774	PSP1 C-terminal conserved region
B4602_RS02310	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
B4602_RS02320	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
B4602_RS02330	COG0084	hydrolase, TatD family'
B4602_RS02335	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
B4602_RS02345	COG4466	Protein conserved in bacteria
B4602_RS02355	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B4602_RS02360	COG0251	oxidation-reduction process
B4602_RS02405	COG2244	polysaccharide biosynthetic process
B4602_RS02410	COG3956	TIGRFAM MazG family protein
B4602_RS02415	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
B4602_RS02425	COG1098	S1 RNA binding domain
B4602_RS02440	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B4602_RS02465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B4602_RS02560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4602_RS02575	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B4602_RS02585	COG3880	PFAM UvrB UvrC protein
B4602_RS02600	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
B4602_RS02605	COG4956	integral membrane protein (PIN domain superfamily)
B4602_RS02630	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
B4602_RS02685	COG2813	Specifically methylates the guanine in position
B4602_RS02725	COG1473	amidohydrolase
B4602_RS02755	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
B4602_RS02760	COG1428	Deoxynucleoside kinase
B4602_RS02765	COG1428	Deoxynucleoside kinase
B4602_RS02775	COG0561	phosphatase activity
B4602_RS02820	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B4602_RS02835	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
B4602_RS02935	COG0095	Lipoate-protein ligase
B4602_RS02940	COG0083	homoserine kinase activity
B4602_RS02960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B4602_RS03045	COG0667	Aldo Keto reductase
B4602_RS03050	COG0655	NAD(P)H dehydrogenase (quinone) activity
B4602_RS03060	COG1078	dGTPase activity
B4602_RS03100	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B4602_RS03105	COG4139	cobalamin transport
B4602_RS03155	COG4974	Belongs to the 'phage' integrase family
B4602_RS03200	COG0803	Belongs to the bacterial solute-binding protein 9 family
B4602_RS03205	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B4602_RS03210	COG1121	(ABC) transporter
B4602_RS03215	COG1321	iron dependent repressor
B4602_RS03225	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
B4602_RS03235	COG1682	transport, permease protein
B4602_RS03240	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B4602_RS03245	COG1216	Glycosyl transferase, family 2
B4602_RS03250	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B4602_RS03260	COG1132	(ABC) transporter
B4602_RS03265	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B4602_RS03275	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4602_RS03280	COG1120	ATPase activity
B4602_RS03285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4602_RS03290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4602_RS03295	COG2376	Dihydroxyacetone kinase
B4602_RS03305	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
B4602_RS03315	COG3949	Membrane
B4602_RS03340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B4602_RS03355	COG1136	(ABC) transporter
B4602_RS03360	COG0577	efflux transmembrane transporter activity
B4602_RS03365	COG1392	Phosphate transport regulator
B4602_RS03370	COG0306	phosphate transporter
B4602_RS03375	COG3942	CHAP domain
B4602_RS03375	COG1388	LysM domain
B4602_RS03385	COG1917	Cupin 2, conserved barrel domain protein
B4602_RS03385	COG4977	sequence-specific DNA binding
B4602_RS03415	COG0583	DNA-binding transcription factor activity
B4602_RS03425	COG2814	Major facilitator Superfamily
B4602_RS03430	COG2839	Protein conserved in bacteria
B4602_RS03460	COG1611	Belongs to the LOG family
B4602_RS03480	COG4988	ABC transporter
B4602_RS03485	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B4602_RS03495	COG0523	cobalamin synthesis protein
B4602_RS03500	COG4989	oxidoreductase activity
B4602_RS03510	COG0471	metal ion transport
B4602_RS03515	COG0415	Belongs to the DNA photolyase family
B4602_RS03545	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B4602_RS03550	COG1349	DNA-binding transcription factor activity
B4602_RS03555	COG1105	Belongs to the carbohydrate kinase PfkB family
B4602_RS03560	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B4602_RS03560	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4602_RS03560	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B4602_RS03565	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B4602_RS03570	COG1253	flavin adenine dinucleotide binding
B4602_RS03575	COG0656	L-ascorbic acid biosynthetic process
B4602_RS03580	COG0463	Glycosyl transferase, family 2
B4602_RS03615	COG0720	synthase
B4602_RS03625	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B4602_RS03625	COG0512	Glutamine amidotransferase of anthranilate synthase
B4602_RS03630	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B4602_RS03660	COG0488	(ABC) transporter
B4602_RS03665	COG0514	ATP-dependent DNA helicase (RecQ)
B4602_RS03670	COG0517	IMP dehydrogenase activity
B4602_RS03670	COG1125	glycine betaine transport
B4602_RS03675	COG1174	glycine betaine transport
B4602_RS03710	COG3104	oligopeptide transport
B4602_RS03740	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B4602_RS03745	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B4602_RS03765	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4602_RS03770	COG4605	iron ion homeostasis
B4602_RS03775	COG4604	ABC transporter, ATP-binding protein
B4602_RS03780	COG4607	ABC-type enterochelin transport system periplasmic component
B4602_RS03840	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B4602_RS03845	COG1739	Uncharacterized protein family UPF0029
B4602_RS03855	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
B4602_RS03860	COG1040	competence protein
B4602_RS03890	COG1388	LysM domain
B4602_RS03890	COG3942	CHAP domain
B4602_RS03955	COG0391	Required for morphogenesis under gluconeogenic growth conditions
B4602_RS04025	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B4602_RS04030	COG1647	Serine aminopeptidase, S33
B4602_RS04035	COG0557	exoribonuclease II activity
B4602_RS04085	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
B4602_RS04085	COG3266	domain, Protein
B4602_RS04110	COG1278	Cold shock
B4602_RS04150	COG0406	alpha-ribazole phosphatase activity
B4602_RS04155	COG1279	arginine transmembrane transporter activity
B4602_RS04180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4602_RS04185	COG1393	Belongs to the ArsC family
B4602_RS04200	COG3878	Protein conserved in bacteria
B4602_RS04220	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
B4602_RS04235	COG2011	ABC-type metal ion transport system permease component
B4602_RS04240	COG1464	Belongs to the NlpA lipoprotein family
B4602_RS04245	COG0582	viral genome integration into host DNA
B4602_RS04340	COG5484	DNA packaging
B4602_RS04340	COG3728	DNA packaging
B4602_RS04365	COG0396	ATPase activity
B4602_RS04370	COG0719	Fe-S assembly protein
B4602_RS04380	COG0822	iron-sulfur transferase activity
B4602_RS04405	COG1253	flavin adenine dinucleotide binding
B4602_RS04420	COG1801	Protein of unknown function DUF72
B4602_RS04425	COG0730	response to heat
B4602_RS04440	COG4470	Protein conserved in bacteria
B4602_RS04450	COG2445	Protein of unknown function DUF86
B4602_RS04480	COG1696	Membrane protein involved in D-alanine export
B4602_RS04490	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
B4602_RS04495	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
B4602_RS04500	COG4837	Protein of unknown function (DUF1462)
B4602_RS04505	COG1252	NADH dehydrogenase
B4602_RS04515	COG0316	Belongs to the HesB IscA family
B4602_RS04525	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B4602_RS04530	COG2056	Na+-H+ antiporter family
B4602_RS04535	COG2050	protein possibly involved in aromatic compounds catabolism
B4602_RS04590	COG1098	S1 RNA binding domain
B4602_RS04595	COG1902	pentaerythritol trinitrate reductase activity
B4602_RS04615	COG0584	glycerophosphoryl diester phosphodiesterase
B4602_RS04635	COG0398	Pfam SNARE associated Golgi protein
B4602_RS04680	COG0561	phosphatase activity
B4602_RS04705	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B4602_RS04720	COG1881	PFAM PEBP family protein
B4602_RS04750	COG0601	transmembrane transport
B4602_RS04755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B4602_RS04760	COG0444	Belongs to the ABC transporter superfamily
B4602_RS04765	COG4608	Belongs to the ABC transporter superfamily
B4602_RS04770	COG4166	transmembrane transport
B4602_RS04775	COG0747	negative chemotaxis
B4602_RS04780	COG0444	Belongs to the ABC transporter superfamily
B4602_RS04785	COG4608	Belongs to the ABC transporter superfamily
B4602_RS04790	COG0601	transmembrane transport
B4602_RS04795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B4602_RS04820	COG1164	Oligoendopeptidase f
B4602_RS04830	COG2346	COG2346, Truncated hemoglobins
B4602_RS04845	COG2357	RelA SpoT domain protein
B4602_RS04855	COG0564	pseudouridine synthase activity
B4602_RS04860	COG2239	Acts as a magnesium transporter
B4602_RS04865	COG0569	domain protein
B4602_RS04865	COG0475	glutathione-regulated potassium exporter activity
B4602_RS04875	COG0628	permease
B4602_RS04880	COG1115	amino acid carrier protein
B4602_RS04920	COG0861	Integral membrane protein TerC family
B4602_RS04935	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B4602_RS04940	COG0737	Belongs to the 5'-nucleotidase family
B4602_RS04955	COG4903	ComK protein
B4602_RS04970	COG4873	Protein conserved in bacteria
B4602_RS05025	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
B4602_RS05035	COG2314	TM2 domain
B4602_RS05040	COG0456	acetyltransferase
B4602_RS05045	COG1575	Belongs to the MenA family. Type 1 subfamily
B4602_RS05055	COG1169	isochorismate synthase
B4602_RS05065	COG2267	carboxylic ester hydrolase activity
B4602_RS05090	COG0436	Aminotransferase
B4602_RS05095	COG3594	Acyltransferase
B4602_RS05125	COG1316	TRANSCRIPTIONal
B4602_RS05130	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B4602_RS05180	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B4602_RS05195	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B4602_RS05235	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
B4602_RS05240	COG4172	Belongs to the ABC transporter superfamily
B4602_RS05245	COG4721	ABC-type cobalt transport system, permease component
B4602_RS05270	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B4602_RS05290	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B4602_RS05295	COG1271	oxidase subunit
B4602_RS05300	COG1294	oxidase, subunit
B4602_RS05305	COG0569	domain protein
B4602_RS05380	COG1176	ABC-type spermidine putrescine transport system, permease component I
B4602_RS05385	COG1177	transmembrane transport
B4602_RS05390	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B4602_RS05415	COG0483	inositol monophosphate 1-phosphatase activity
B4602_RS05425	COG1217	gtp-binding protein TYPA
B4602_RS05435	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B4602_RS05445	COG0772	Belongs to the SEDS family
B4602_RS05480	COG3679	Belongs to the UPF0342 family
B4602_RS05500	COG0742	ribosomal rna small subunit methyltransferase
B4602_RS05560	COG4509	Sortase family
B4602_RS05575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B4602_RS05610	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B4602_RS05610	COG1796	DNA polymerase
B4602_RS05635	COG2009	succinate dehydrogenase
B4602_RS05640	COG1053	succinate dehydrogenase
B4602_RS05645	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B4602_RS05760	COG1288	antiporter activity
B4602_RS05795	COG1011	Hydrolase
B4602_RS05820	COG4839	cell division protein FtsL
B4602_RS05825	COG0768	penicillin binding
B4602_RS05840	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B4602_RS05845	COG0849	cell division
B4602_RS05860	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B4602_RS05870	COG0762	integral membrane protein
B4602_RS05875	COG2302	S4 RNA-binding domain
B4602_RS05880	COG3599	regulation of cell shape
B4602_RS05890	COG2514	catechol 2,3-dioxygenase activity
B4602_RS05905	COG0564	pseudouridine synthase activity
B4602_RS05915	COG2233	PERMEase
B4602_RS05960	COG1293	RNA-binding protein homologous to eukaryotic snRNP
B4602_RS05975	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B4602_RS05980	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B4602_RS05990	COG2314	TM2 domain
B4602_RS06005	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B4602_RS06005	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B4602_RS06015	COG0631	protein serine/threonine phosphatase activity
B4602_RS06030	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B4602_RS06045	COG1302	Protein conserved in bacteria
B4602_RS06095	COG1196	nuclear chromosome segregation
B4602_RS06100	COG0552	protein localization to endoplasmic reticulum
B4602_RS06110	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B4602_RS06165	COG0758	DNA mediated transformation
B4602_RS06265	COG0195	Participates in both transcription termination and antitermination
B4602_RS06270	COG2740	Nucleic-acid-binding protein implicated in transcription termination
B4602_RS06295	COG0196	riboflavin kinase activity
B4602_RS06325	COG2188	Transcriptional regulator
B4602_RS06330	COG0612	Peptidase, M16
B4602_RS06335	COG0612	Peptidase, M16
B4602_RS06340	COG0300	oxidoreductase activity
B4602_RS06360	COG1058	Belongs to the CinA family
B4602_RS06360	COG1546	Belongs to the CinA family
B4602_RS06380	COG1692	metallophosphoesterase
B4602_RS06385	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
B4602_RS06385	COG0674	pyruvate-flavodoxin oxidoreductase activity
B4602_RS06390	COG1013	pyruvate-flavodoxin oxidoreductase activity
B4602_RS06425	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
B4602_RS06430	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B4602_RS06455	COG1923	regulation of RNA biosynthetic process
B4602_RS06465	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B4602_RS06470	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
B4602_RS06475	COG0789	Transcriptional regulator
B4602_RS06485	COG0582	viral genome integration into host DNA
B4602_RS06600	COG1783	phage Terminase large subunit
B4602_RS06660	COG1131	(ABC) transporter
B4602_RS06675	COG2197	response regulator
B4602_RS06685	COG1525	nuclease
B4602_RS06700	COG0527	aspartate kinase activity
B4602_RS06705	COG0460	homoserine dehydrogenase
B4602_RS06710	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B4602_RS06735	COG0833	amino acid
B4602_RS06765	COG2340	Cysteine-rich secretory protein family
B4602_RS06800	COG4846	Membrane protein involved in cytochrome C biogenesis
B4602_RS06820	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B4602_RS06840	COG0824	Thioesterase
B4602_RS06880	COG1115	amino acid carrier protein
B4602_RS06895	COG0628	permease
B4602_RS06925	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B4602_RS06935	COG1363	Peptidase, m42
B4602_RS06940	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B4602_RS06945	COG0512	Glutamine amidotransferase of anthranilate synthase
B4602_RS06985	COG0561	phosphatase activity
B4602_RS07030	COG0704	Plays a role in the regulation of phosphate uptake
B4602_RS07040	COG0581	inorganic phosphate transmembrane transporter activity
B4602_RS07045	COG0573	inorganic phosphate transmembrane transporter activity
B4602_RS07065	COG0488	(ABC) transporter
B4602_RS07075	COG0527	aspartate kinase activity
B4602_RS07080	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B4602_RS07155	COG4548	von Willebrand factor, type A
B4602_RS07160	COG0714	Associated with various cellular activities
B4602_RS07205	COG0671	phosphoesterase, PA-phosphatase related
B4602_RS07280	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
B4602_RS07305	COG0531	amino acid
B4602_RS07320	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4602_RS07325	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
B4602_RS07345	COG0116	Belongs to the methyltransferase superfamily
B4602_RS07380	COG4499	WXG100 protein secretion system (Wss), protein YukC
B4602_RS07380	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B4602_RS07390	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B4602_RS07395	COG3935	DnaD domain protein
B4602_RS07420	COG0438	transferase activity, transferring glycosyl groups
B4602_RS07425	COG1694	Mazg nucleotide pyrophosphohydrolase
B4602_RS07430	COG2738	Putative neutral zinc metallopeptidase
B4602_RS07435	COG4347	Protein of unknown function (DUF1405)
B4602_RS07475	COG0142	geranyltranstransferase activity
B4602_RS07525	COG0492	ferredoxin-NADP+ reductase activity
B4602_RS07540	COG0514	ATP-dependent DNA helicase (RecQ)
B4602_RS07550	COG1141	Ferredoxin
B4602_RS07595	COG5002	protein histidine kinase activity
B4602_RS07600	COG0745	RESPONSE REGULATOR receiver
B4602_RS07605	COG1187	pseudouridine synthase activity
B4602_RS07630	COG0735	belongs to the Fur family
B4602_RS07635	COG0494	nUDIX hydrolase
B4602_RS07640	COG0667	Aldo Keto reductase
B4602_RS07650	COG4221	oxidoreductase activity
B4602_RS07665	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B4602_RS07675	COG0366	Alpha amylase catalytic
B4602_RS07680	COG1609	Transcriptional regulator
B4602_RS07705	COG2195	Cleaves the N-terminal amino acid of tripeptides
B4602_RS07715	COG4129	membrane
B4602_RS07725	COG0508	dehydrogenase complex catalyzes the overall conversion of
B4602_RS07730	COG0022	dehydrogenase e1 component
B4602_RS07735	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B4602_RS07740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B4602_RS07745	COG0497	DNA recombination
B4602_RS07775	COG1302	Protein conserved in bacteria
B4602_RS07780	COG0439	Biotin carboxylase
B4602_RS07785	COG0511	ligase activity, forming carbon-carbon bonds
B4602_RS07795	COG0006	proline dipeptidase activity
B4602_RS07820	COG0095	Lipoate-protein ligase
B4602_RS07825	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B4602_RS07870	COG4537	Required for transformation and DNA binding
B4602_RS07875	COG1459	type II secretion system
B4602_RS07880	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B4602_RS07885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4602_RS07890	COG0011	TIGRFAM Protein of
B4602_RS07895	COG1940	carbohydrate kinase activity
B4602_RS07900	COG4483	Protein conserved in bacteria
B4602_RS07910	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B4602_RS07920	COG0768	penicillin binding
B4602_RS07935	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B4602_RS07940	COG1121	(ABC) transporter
B4602_RS07950	COG0513	Belongs to the DEAD box helicase family
B4602_RS07960	COG2384	SAM-dependent methyltransferase
B4602_RS08000	COG0295	cytidine deaminase activity
B4602_RS08015	COG1702	phosphate starvation-inducible protein PhoH
B4602_RS08030	COG1030	water channel activity
B4602_RS08040	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B4602_RS08045	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B4602_RS08075	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B4602_RS08095	COG1466	dna polymerase III delta subunit
B4602_RS08100	COG2333	competence protein COMEC
B4602_RS08100	COG0658	competence protein
B4602_RS08105	COG2131	deaminase
B4602_RS08110	COG2183	response to ionizing radiation
B4602_RS08115	COG2226	methyltransferase
B4602_RS08120	COG0799	negative regulation of ribosome biogenesis
B4602_RS08125	COG1713	HD superfamily hydrolase involved in NAD metabolism
B4602_RS08135	COG1534	Rna-binding protein
B4602_RS08145	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B4602_RS08150	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
B4602_RS08170	COG1914	H( )-stimulated, divalent metal cation uptake system
B4602_RS08180	COG0439	Biotin carboxylase
B4602_RS08185	COG0511	ligase activity, forming carbon-carbon bonds
B4602_RS08190	COG1984	allophanate hydrolase subunit 2
B4602_RS08195	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
B4602_RS08210	COG0826	peptidase U32
B4602_RS08215	COG0826	peptidase U32
B4602_RS08245	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B4602_RS08265	COG1104	cysteine desulfurase activity
B4602_RS08270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4602_RS08280	COG3237	CsbD-like
B4602_RS08285	COG1959	2 iron, 2 sulfur cluster binding
B4602_RS08290	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B4602_RS08295	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B4602_RS08340	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
B4602_RS08340	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B4602_RS08345	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B4602_RS08345	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B4602_RS08350	COG1862	Preprotein translocase
B4602_RS08390	COG2868	ribosomal protein
B4602_RS08445	COG0285	dihydrofolate synthase activity
B4602_RS08455	COG2818	Glycosylase
B4602_RS08490	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B4602_RS08525	COG4112	unkown
B4602_RS08550	COG0833	amino acid
B4602_RS08565	COG1484	DNA-dependent DNA replication
B4602_RS08595	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4602_RS08595	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4602_RS08605	COG5002	protein histidine kinase activity
B4602_RS08610	COG0745	RESPONSE REGULATOR receiver
B4602_RS08625	COG0372	Belongs to the citrate synthase family
B4602_RS08630	COG1113	amino acid transport
B4602_RS08660	COG0281	malic enzyme
B4602_RS08670	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
B4602_RS08680	COG4109	DRTGG domain
B4602_RS08720	COG0827	DNA restriction-modification system
B4602_RS08740	COG1104	cysteine desulfurase activity
B4602_RS08755	COG1956	GAF domain-containing protein
B4602_RS08770	COG0584	glycerophosphoryl diester phosphodiesterase
B4602_RS08775	COG1764	response to oxidative stress
B4602_RS08780	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B4602_RS08785	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B4602_RS08800	COG1263	PTS System
B4602_RS08800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4602_RS08805	COG0204	Acyl-transferase
B4602_RS08810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B4602_RS08830	COG5386	Cell surface protein
B4602_RS08840	COG2759	Belongs to the formate--tetrahydrofolate ligase family
B4602_RS08845	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B4602_RS08850	COG0454	-acetyltransferase
B4602_RS08870	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
B4602_RS08870	COG1605	Chorismate mutase
B4602_RS08895	COG1674	ftsk spoiiie
B4602_RS08900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B4602_RS08910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4602_RS08915	COG1363	Peptidase, m42
B4602_RS08925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4602_RS08935	COG0510	thiamine kinase activity
B4602_RS08955	COG1187	pseudouridine synthase activity
B4602_RS08960	COG2244	polysaccharide biosynthetic process
B4602_RS08965	COG2081	HI0933 family
B4602_RS08985	COG2814	Major facilitator Superfamily
B4602_RS08990	COG1242	4 iron, 4 sulfur cluster binding
B4602_RS08995	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
B4602_RS09005	COG2267	carboxylic ester hydrolase activity
B4602_RS09040	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B4602_RS09040	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B4602_RS09060	COG4193	domain, Protein
B4602_RS09060	COG5632	N-Acetylmuramoyl-L-alanine amidase
B4602_RS09060	COG3266	domain, Protein
B4602_RS09090	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B4602_RS09115	COG0656	L-ascorbic acid biosynthetic process
B4602_RS09135	COG1506	peptidase
B4602_RS09225	COG5492	domain, Protein
B4602_RS09420	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
B4602_RS09450	COG1131	(ABC) transporter
B4602_RS09455	COG0537	adenosine 5'-monophosphoramidase activity
B4602_RS09490	COG0420	3'-5' exonuclease activity
B4602_RS09520	COG2197	response regulator
B4602_RS09525	COG4585	Histidine kinase
B4602_RS09525	COG2203	Gaf domain
B4602_RS09530	COG0564	pseudouridine synthase activity
B4602_RS09565	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B4602_RS09570	COG1126	abc transporter atp-binding protein
B4602_RS09575	COG0765	amino acid transport
B4602_RS09745	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B4602_RS09750	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B4602_RS09760	COG4129	membrane
B4602_RS09785	COG1988	membrane-bound metal-dependent
B4602_RS09800	COG1388	LysM domain
B4602_RS09800	COG1134	teichoic acid transport
B4602_RS09830	COG0535	radical SAM domain protein
B4602_RS09835	COG1607	acyl-coa hydrolase
B4602_RS09840	COG2309	aminopeptidase activity
B4602_RS09860	COG1295	ribonuclease BN
B4602_RS09985	COG4851	CamS sex pheromone cAM373 precursor
B4602_RS09995	COG0210	DNA helicase
B4602_RS10005	COG4496	protein, YerC YecD
B4602_RS10045	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B4602_RS10055	COG0077	Prephenate dehydratase
B4602_RS10075	COG1335	isochorismatase
B4602_RS10095	COG1012	belongs to the aldehyde dehydrogenase family
B4602_RS10150	COG1131	(ABC) transporter
B4602_RS10165	COG1725	Transcriptional regulator
B4602_RS10220	COG1388	LysM domain
B4602_RS10220	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4602_RS10245	COG1388	LysM domain
B4602_RS10245	COG5632	N-Acetylmuramoyl-L-alanine amidase
B4602_RS10290	COG0739	heme binding
B4602_RS10345	COG4695	Portal protein
B4602_RS10530	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B4602_RS10585	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
B4602_RS10590	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B4602_RS10595	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B4602_RS10680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B4602_RS10685	COG1621	beta-fructofuranosidase activity
B4602_RS10690	COG1609	Transcriptional regulator
B4602_RS10695	COG0004	ammonium transporteR
B4602_RS10700	COG0425	Belongs to the sulfur carrier protein TusA family
B4602_RS10705	COG2391	methyltransferase activity
B4602_RS10715	COG0488	(ABC) transporter
B4602_RS10730	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B4602_RS10740	COG0456	acetyltransferase
B4602_RS10745	COG1214	PFAM Peptidase M22, glycoprotease
B4602_RS10750	COG0802	atpase or kinase
B4602_RS10765	COG0028	Belongs to the TPP enzyme family
B4602_RS10850	COG2183	response to ionizing radiation
B4602_RS10855	COG1191	sigma factor activity
B4602_RS10865	COG1366	Belongs to the anti-sigma-factor antagonist family
B4602_RS10870	COG2208	phosphoserine phosphatase activity
B4602_RS10905	COG3428	Bacterial PH domain
B4602_RS10935	COG2205	protein histidine kinase activity
B4602_RS10940	COG0745	RESPONSE REGULATOR receiver
B4602_RS10950	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B4602_RS10960	COG0772	Belongs to the SEDS family
B4602_RS10975	COG1937	Protein conserved in bacteria
B4602_RS10985	COG1418	mRNA catabolic process
B4602_RS11030	COG0629	single-stranded DNA binding
B4602_RS11105	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B4602_RS11130	COG0009	L-threonylcarbamoyladenylate synthase
B4602_RS11135	COG2890	protein-(glutamine-N5) methyltransferase activity
B4602_RS11160	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B4602_RS11200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4602_RS11250	COG0813	purine-nucleoside phosphorylase activity
B4602_RS11255	COG0783	Belongs to the Dps family
B4602_RS11275	COG1482	cell wall glycoprotein biosynthetic process
B4602_RS11280	COG0702	epimerase
B4602_RS11285	COG0640	Transcriptional regulator
B4602_RS11320	COG0561	phosphatase activity
B4602_RS11325	COG1119	ATPase activity
B4602_RS11340	COG3711	transcriptional antiterminator
B4602_RS11370	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
B4602_RS11435	COG0489	protein tyrosine kinase activity
B4602_RS11440	COG2814	Major facilitator Superfamily
B4602_RS11455	COG1272	protein, Hemolysin III
B4602_RS11465	COG1988	membrane-bound metal-dependent
B4602_RS11475	COG3314	Sporulation integral membrane protein YlbJ
B4602_RS11480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4602_RS11485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4602_RS11490	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
B4602_RS11500	COG3457	Alanine racemase
B4602_RS11505	COG4264	IucA IucC family
B4602_RS11510	COG2814	Major facilitator Superfamily
B4602_RS11535	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B4602_RS11545	COG2130	NADP-dependent
B4602_RS11615	COG0656	L-ascorbic acid biosynthetic process
B4602_RS11620	COG0789	Transcriptional regulator
B4602_RS11630	COG5492	domain, Protein
B4602_RS11640	COG3527	Alpha-acetolactate decarboxylase
B4602_RS11645	COG0028	Belongs to the TPP enzyme family
B4602_RS11725	COG0201	protein transport
B4602_RS11840	COG2252	PERMEase
B4602_RS11890	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B4602_RS11960	COG1763	Mo-molybdopterin cofactor biosynthetic process
B4602_RS11980	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B4602_RS11985	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
B4602_RS11990	COG4149	molybdate abc transporter
B4602_RS11995	COG0725	ABC transporter, periplasmic molybdate-binding protein
B4602_RS12010	COG1268	BioY protein
B4602_RS12025	COG1960	acyl-CoA dehydrogenase activity
B4602_RS12030	COG4413	Urea transporter
B4602_RS12095	COG3942	CHAP domain
B4602_RS12105	COG1757	Na H antiporter
B4602_RS12120	COG3942	CHAP domain
B4602_RS12205	COG1113	amino acid transport
B4602_RS12225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B4602_RS12230	COG0385	Bile acid
B4602_RS12245	COG1737	Transcriptional regulator
B4602_RS12265	COG1028	Short-chain dehydrogenase reductase Sdr
B4602_RS12270	COG1473	amidohydrolase
B4602_RS12285	COG0583	DNA-binding transcription factor activity
B4602_RS12305	COG2258	MOSC domain
B4602_RS12325	COG1668	transmembrane transport
B4602_RS12330	COG4152	abc transporter atp-binding protein
B4602_RS12335	COG3152	Membrane
B4602_RS12355	COG0786	glutamate:sodium symporter activity
B4602_RS12365	COG0598	Magnesium transport protein CorA
B4602_RS12380	COG0657	acetylesterase activity
B4602_RS12390	COG2814	Major facilitator Superfamily
B4602_RS12395	COG1566	PFAM secretion protein HlyD family protein
B4602_RS12405	COG2814	Major facilitator Superfamily
B4602_RS12470	COG1620	l-lactate permease
B4602_RS12490	COG0604	alcohol dehydrogenase
B4602_RS12495	COG0456	acetyltransferase
B4602_RS12520	COG1511	domain protein
B4602_RS12535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4602_RS12535	COG1263	PTS System
B4602_RS12550	COG3871	stress protein (general stress protein 26)
B4602_RS12600	COG2181	nitrate reductase activity
B4602_RS12610	COG1140	nitrate reductase beta subunit
B4602_RS12615	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
B4602_RS12625	COG2146	nitrite reductase [NAD(P)H] activity
B4602_RS12630	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B4602_RS12640	COG0454	-acetyltransferase
B4602_RS12645	COG2116	formate transmembrane transporter activity
B4602_RS12660	COG0803	Belongs to the bacterial solute-binding protein 9 family
B4602_RS12660	COG3443	Belongs to the bacterial solute-binding protein 9 family
B4602_RS12700	COG1126	abc transporter atp-binding protein
B4602_RS12705	COG0765	amino acid transport
B4602_RS12710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4602_RS12715	COG2814	Major facilitator Superfamily
B4602_RS12735	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B4602_RS12785	COG0156	8-amino-7-oxononanoate synthase activity
B4602_RS12795	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B4602_RS12800	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
B4602_RS12815	COG1132	(ABC) transporter
B4602_RS12820	COG2375	cellular response to nickel ion
B4602_RS12820	COG1132	(ABC) transporter
B4602_RS12840	COG1929	Belongs to the glycerate kinase type-1 family
B4602_RS12850	COG2814	Major facilitator Superfamily
B4602_RS12870	COG1113	amino acid transport
B4602_RS12885	COG0531	amino acid
B4602_RS12910	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B4602_RS12920	COG1174	glycine betaine transport
B4602_RS12930	COG1174	glycine betaine transport
B4602_RS12940	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
B4602_RS12950	COG0531	amino acid
B4602_RS12960	COG2272	Belongs to the type-B carboxylesterase lipase family
B4602_RS12965	COG2814	Major facilitator Superfamily
B4602_RS12970	COG0390	transport system, permease component
B4602_RS12975	COG4619	ABC transporter
B4602_RS12980	COG1363	Peptidase, m42
B4602_RS13000	COG4808	Protein conserved in bacteria
B4602_RS13005	COG0069	glutamate synthase activity
B4602_RS13020	COG1124	(ABC) transporter
B4602_RS13025	COG0444	Belongs to the ABC transporter superfamily
B4602_RS13030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B4602_RS13035	COG0601	transmembrane transport
B4602_RS13065	COG1028	Short-chain dehydrogenase reductase Sdr
B4602_RS13070	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
B4602_RS13075	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B4602_RS13130	COG0494	nUDIX hydrolase
B4602_RS13170	COG1846	Transcriptional regulator
B4602_RS13205	COG1070	Carbohydrate kinase
B4602_RS13210	COG1802	Transcriptional regulator
B4602_RS13215	COG0789	Transcriptional regulator
B4602_RS13220	COG2357	RelA SpoT domain protein
B4602_RS13225	COG4876	unkown
B4602_RS13240	COG2271	Major facilitator Superfamily
B4602_RS13245	COG0586	Pfam SNARE associated Golgi protein
B4602_RS13255	COG2814	Major facilitator Superfamily
B4602_RS13260	COG1846	Transcriptional regulator
B4602_RS13270	COG1131	(ABC) transporter
B4602_RS13290	COG0400	carboxylic ester hydrolase activity
B4602_RS13295	COG0346	lactoylglutathione lyase activity
B4602_RS13300	COG1846	Transcriptional regulator
B4602_RS13310	COG2514	catechol 2,3-dioxygenase activity
B4602_RS13325	COG0561	phosphatase activity
B4602_RS13330	COG1131	(ABC) transporter
B4602_RS13340	COG3764	Sortase (surface protein transpeptidase)
B4602_RS13370	COG1760	l-serine dehydratase
B4602_RS13375	COG1760	l-serine dehydratase
B4602_RS13390	COG0697	spore germination
B4602_RS13395	COG0657	acetylesterase activity
B4602_RS13415	COG0028	Belongs to the TPP enzyme family
B4602_RS13430	COG0583	DNA-binding transcription factor activity
B4602_RS13440	COG3942	CHAP domain
B4602_RS13450	COG3425	synthase
B4602_RS13455	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B4602_RS13480	COG2409	Drug exporters of the RND superfamily
B4602_RS13525	COG0436	Aminotransferase
B4602_RS13555	COG3942	CHAP domain
B4602_RS13560	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B4602_RS13560	COG2755	lipolytic protein G-D-S-L family
B4602_RS13635	COG0596	Alpha beta hydrolase
B4602_RS13675	COG3001	Fructosamine kinase
B4602_RS13680	COG0167	dihydroorotate dehydrogenase activity
B4602_RS13735	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B4602_RS13740	COG3527	Alpha-acetolactate decarboxylase
B4602_RS13755	COG0531	amino acid
B4602_RS13785	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B4602_RS13805	COG1012	belongs to the aldehyde dehydrogenase family
B4602_RS13815	COG1510	regulation of RNA biosynthetic process
B4602_RS13830	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B4602_RS13855	COG2851	Citrate transporter
B4602_RS13870	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B4602_RS13880	COG0386	Belongs to the glutathione peroxidase family
B4602_RS13905	COG1136	(ABC) transporter
B4602_RS13910	COG2205	protein histidine kinase activity
B4602_RS13915	COG0745	RESPONSE REGULATOR receiver
B4602_RS13925	COG1785	Belongs to the alkaline phosphatase family
B4602_RS13935	COG1846	Transcriptional regulator
B4602_RS13980	COG1438	arginine binding
B4602_RS14000	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4602_RS14000	COG3711	transcriptional antiterminator
B4602_RS14005	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B4602_RS14005	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4602_RS14005	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B4602_RS14010	COG1482	cell wall glycoprotein biosynthetic process
B4602_RS14020	COG1705	Flagellar rod assembly protein muramidase FlgJ
B4602_RS14020	COG3942	CHAP domain
B4602_RS14025	COG3433	isochorismatase activity
B4602_RS14025	COG1535	isochorismatase
B4602_RS14040	COG0438	transferase activity, transferring glycosyl groups
B4602_RS14075	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B4602_RS14095	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B4602_RS14195	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B4602_RS14270	COG0471	metal ion transport
B4602_RS14275	COG2962	Rard protein
B4602_RS14285	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
B4602_RS14300	COG1136	(ABC) transporter
B4602_RS14305	COG0577	efflux transmembrane transporter activity
B4602_RS14335	COG1278	Cold shock
B4602_RS14360	COG1475	DNA binding
B4602_RS14425	COG0583	DNA-binding transcription factor activity
B4602_RS14490	COG1136	(ABC) transporter
B4602_RS14490	COG0577	efflux transmembrane transporter activity