locus-tag	class	description
I1A60_RS00015	COG2501	S4 domain
I1A60_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I1A60_RS00060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I1A60_RS00070	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
I1A60_RS00080	COG0305	Participates in initiation and elongation during chromosome replication
I1A60_RS00110	COG4863	YycH protein
I1A60_RS00120	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I1A60_RS00125	COG0737	Belongs to the 5'-nucleotidase family
I1A60_RS00155	COG0584	glycerophosphoryl diester phosphodiesterase
I1A60_RS00160	COG2030	dehydratase
I1A60_RS00225	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I1A60_RS00225	COG1199	ATP-dependent helicase activity
I1A60_RS00300	COG1401	restriction endodeoxyribonuclease activity
I1A60_RS00305	COG4268	DNA restriction-modification system
I1A60_RS00310	COG0456	acetyltransferase
I1A60_RS00325	COG0730	response to heat
I1A60_RS00330	COG1937	Protein conserved in bacteria
I1A60_RS00335	COG2210	Belongs to the sulfur carrier protein TusA family
I1A60_RS00340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I1A60_RS00370	COG1073	alpha beta
I1A60_RS00435	COG1473	amidohydrolase
I1A60_RS00445	COG1283	sodium-dependent phosphate transmembrane transporter activity
I1A60_RS00450	COG4716	Myosin-crossreactive antigen
I1A60_RS00455	COG0697	spore germination
I1A60_RS00470	COG1620	l-lactate permease
I1A60_RS00485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I1A60_RS00490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I1A60_RS00495	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I1A60_RS00505	COG2423	ornithine cyclodeaminase activity
I1A60_RS00510	COG4264	IucA IucC family
I1A60_RS00515	COG2814	Major facilitator Superfamily
I1A60_RS00520	COG4264	IucA IucC family
I1A60_RS00525	COG4264	IucA IucC family
I1A60_RS00535	COG0019	diaminopimelate decarboxylase activity
I1A60_RS00540	COG1475	DNA binding
I1A60_RS00560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I1A60_RS00565	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I1A60_RS00570	COG0438	transferase activity, transferring glycosyl groups
I1A60_RS00600	COG0813	purine-nucleoside phosphorylase activity
I1A60_RS00605	COG2814	Major facilitator Superfamily
I1A60_RS00625	COG3639	organic phosphonate transmembrane transporter activity
I1A60_RS00645	COG0737	Belongs to the 5'-nucleotidase family
I1A60_RS00660	COG1454	alcohol dehydrogenase
I1A60_RS00660	COG1012	belongs to the aldehyde dehydrogenase family
I1A60_RS00685	COG1086	Polysaccharide biosynthesis protein
I1A60_RS00695	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I1A60_RS00725	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I1A60_RS00735	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I1A60_RS00740	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I1A60_RS00750	COG2832	Protein of unknown function (DUF454)
I1A60_RS00785	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I1A60_RS00790	COG1960	acyl-CoA dehydrogenase activity
I1A60_RS00795	COG5609	conserved protein (DUF2294)
I1A60_RS00845	COG1114	Component of the transport system for branched-chain amino acids
I1A60_RS00850	COG1335	isochorismatase
I1A60_RS00855	COG3961	Belongs to the TPP enzyme family
I1A60_RS00885	COG1737	Transcriptional regulator
I1A60_RS00910	COG1136	(ABC) transporter
I1A60_RS00915	COG0577	efflux transmembrane transporter activity
I1A60_RS00915	COG1136	(ABC) transporter
I1A60_RS00935	COG1131	(ABC) transporter
I1A60_RS00950	COG0601	transmembrane transport
I1A60_RS00955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I1A60_RS00965	COG0405	Gamma-glutamyltransferase
I1A60_RS00985	COG3842	ATPase activity
I1A60_RS00995	COG1175	transmembrane transport
I1A60_RS01000	COG3833	ABC-type maltose transport systems, permease component
I1A60_RS01005	COG0673	inositol 2-dehydrogenase activity
I1A60_RS01010	COG0673	inositol 2-dehydrogenase activity
I1A60_RS01020	COG1755	Isoprenylcysteine carboxyl methyltransferase
I1A60_RS01075	COG0183	Belongs to the thiolase family
I1A60_RS01085	COG1960	acyl-CoA dehydrogenase activity
I1A60_RS01090	COG0318	PFAM AMP-dependent synthetase and ligase
I1A60_RS01115	COG1073	alpha beta
I1A60_RS01120	COG0747	negative chemotaxis
I1A60_RS01125	COG3189	MarR family transcriptional regulator
I1A60_RS01150	COG2190	(PTS) system
I1A60_RS01150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I1A60_RS01150	COG1263	PTS System
I1A60_RS01155	COG1957	nucleoside hydrolase
I1A60_RS01175	COG3414	Phosphotransferase system galactitol-specific IIB component
I1A60_RS01180	COG3775	system Galactitol-specific IIC component
I1A60_RS01185	COG1063	alcohol dehydrogenase
I1A60_RS01195	COG1063	alcohol dehydrogenase
I1A60_RS01205	COG1063	alcohol dehydrogenase
I1A60_RS01210	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I1A60_RS01215	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I1A60_RS01225	COG1063	alcohol dehydrogenase
I1A60_RS01230	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I1A60_RS01265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I1A60_RS01270	COG1263	PTS System
I1A60_RS01270	COG2190	(PTS) system
I1A60_RS01270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I1A60_RS01275	COG2723	6-phospho-beta-galactosidase activity
I1A60_RS01285	COG2226	methyltransferase
I1A60_RS01345	COG1131	(ABC) transporter
I1A60_RS01365	COG1388	LysM domain
I1A60_RS01365	COG3942	CHAP domain
I1A60_RS01545	COG1114	Component of the transport system for branched-chain amino acids
I1A60_RS01550	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
I1A60_RS01555	COG0577	efflux transmembrane transporter activity
I1A60_RS01580	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I1A60_RS01585	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I1A60_RS01610	COG3314	Sporulation integral membrane protein YlbJ
I1A60_RS01635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I1A60_RS01665	COG3037	sugar-specific permease SgaT UlaA
I1A60_RS01675	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I1A60_RS01680	COG3711	transcriptional antiterminator
I1A60_RS01700	COG2271	Major facilitator Superfamily
I1A60_RS01705	COG0346	lactoylglutathione lyase activity
I1A60_RS01710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I1A60_RS01715	COG0431	NADPH-dependent FMN reductase
I1A60_RS01730	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I1A60_RS01735	COG2822	iron ion transport
I1A60_RS01745	COG0672	)-iron permease
I1A60_RS01750	COG0805	protein transport
I1A60_RS01755	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I1A60_RS01765	COG1476	TRANSCRIPTIONal
I1A60_RS01775	COG1131	(ABC) transporter
I1A60_RS01805	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I1A60_RS01805	COG0646	methionine synthase
I1A60_RS01810	COG0626	cystathionine gamma-synthase activity
I1A60_RS01815	COG0626	cystathionine gamma-synthase activity
I1A60_RS01820	COG1475	DNA binding
I1A60_RS01825	COG0668	transmembrane transport
I1A60_RS01830	COG4481	Protein conserved in bacteria
I1A60_RS01835	COG0012	GTP binding
I1A60_RS01920	COG3634	alkyl hydroperoxide reductase activity
I1A60_RS01935	COG1823	symporter activity
I1A60_RS01965	COG2233	PERMEase
I1A60_RS02005	COG1683	Conserved Protein
I1A60_RS02015	COG3759	membrane
I1A60_RS02160	COG0523	cobalamin synthesis protein
I1A60_RS02185	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I1A60_RS02195	COG5609	conserved protein (DUF2294)
I1A60_RS02210	COG1647	Serine aminopeptidase, S33
I1A60_RS02220	COG0733	neurotransmitter:sodium symporter activity
I1A60_RS02225	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I1A60_RS02230	COG0626	cystathionine gamma-synthase activity
I1A60_RS02240	COG2011	ABC-type metal ion transport system permease component
I1A60_RS02245	COG1464	Belongs to the NlpA lipoprotein family
I1A60_RS02280	COG0583	DNA-binding transcription factor activity
I1A60_RS02285	COG0067	glutamate synthase
I1A60_RS02285	COG0070	glutamate synthase
I1A60_RS02285	COG0069	glutamate synthase activity
I1A60_RS02290	COG0493	'glutamate synthase
I1A60_RS02300	COG1263	PTS System
I1A60_RS02300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I1A60_RS02305	COG0366	Alpha amylase catalytic
I1A60_RS02310	COG2188	Transcriptional regulator
I1A60_RS02330	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I1A60_RS02365	COG1982	Orn Lys Arg decarboxylase major
I1A60_RS02375	COG3870	Protein conserved in bacteria
I1A60_RS02380	COG0470	DNA polymerase III
I1A60_RS02385	COG1774	PSP1 C-terminal conserved region
I1A60_RS02395	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I1A60_RS02405	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I1A60_RS02415	COG0084	hydrolase, TatD family'
I1A60_RS02420	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I1A60_RS02430	COG4466	Protein conserved in bacteria
I1A60_RS02440	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I1A60_RS02445	COG0251	oxidation-reduction process
I1A60_RS02485	COG2244	polysaccharide biosynthetic process
I1A60_RS02490	COG3956	TIGRFAM MazG family protein
I1A60_RS02495	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I1A60_RS02505	COG1098	S1 RNA binding domain
I1A60_RS02520	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I1A60_RS02545	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I1A60_RS02640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I1A60_RS02655	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I1A60_RS02665	COG3880	PFAM UvrB UvrC protein
I1A60_RS02680	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I1A60_RS02685	COG4956	integral membrane protein (PIN domain superfamily)
I1A60_RS02705	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I1A60_RS02760	COG2813	Specifically methylates the guanine in position
I1A60_RS02800	COG1473	amidohydrolase
I1A60_RS02830	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I1A60_RS02835	COG1428	Deoxynucleoside kinase
I1A60_RS02840	COG1428	Deoxynucleoside kinase
I1A60_RS02850	COG0561	phosphatase activity
I1A60_RS02890	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I1A60_RS02995	COG0095	Lipoate-protein ligase
I1A60_RS03000	COG0083	homoserine kinase activity
I1A60_RS03020	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I1A60_RS03120	COG0667	Aldo Keto reductase
I1A60_RS03130	COG0655	NAD(P)H dehydrogenase (quinone) activity
I1A60_RS03140	COG1078	dGTPase activity
I1A60_RS03175	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I1A60_RS03180	COG4139	cobalamin transport
I1A60_RS03230	COG4974	Belongs to the 'phage' integrase family
I1A60_RS03275	COG0803	Belongs to the bacterial solute-binding protein 9 family
I1A60_RS03280	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I1A60_RS03285	COG1121	(ABC) transporter
I1A60_RS03290	COG1321	iron dependent repressor
I1A60_RS03300	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I1A60_RS03310	COG1682	transport, permease protein
I1A60_RS03315	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I1A60_RS03325	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I1A60_RS03330	COG1686	Belongs to the peptidase S11 family
I1A60_RS03335	COG1132	(ABC) transporter
I1A60_RS03340	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I1A60_RS03350	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I1A60_RS03355	COG1120	ATPase activity
I1A60_RS03360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I1A60_RS03365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I1A60_RS03370	COG2376	Dihydroxyacetone kinase
I1A60_RS03380	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I1A60_RS03390	COG3949	Membrane
I1A60_RS03410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I1A60_RS03425	COG1136	(ABC) transporter
I1A60_RS03430	COG0577	efflux transmembrane transporter activity
I1A60_RS03435	COG1392	Phosphate transport regulator
I1A60_RS03440	COG0306	phosphate transporter
I1A60_RS03445	COG3942	CHAP domain
I1A60_RS03445	COG1388	LysM domain
I1A60_RS03455	COG4977	sequence-specific DNA binding
I1A60_RS03455	COG1917	Cupin 2, conserved barrel domain protein
I1A60_RS03485	COG0583	DNA-binding transcription factor activity
I1A60_RS03490	COG2814	Major facilitator Superfamily
I1A60_RS03495	COG2839	Protein conserved in bacteria
I1A60_RS03525	COG1611	Belongs to the LOG family
I1A60_RS03545	COG4988	ABC transporter
I1A60_RS03550	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I1A60_RS03560	COG0523	cobalamin synthesis protein
I1A60_RS03565	COG4989	oxidoreductase activity
I1A60_RS03575	COG0471	metal ion transport
I1A60_RS03580	COG0415	Belongs to the DNA photolyase family
I1A60_RS03610	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I1A60_RS03615	COG1349	DNA-binding transcription factor activity
I1A60_RS03620	COG1105	Belongs to the carbohydrate kinase PfkB family
I1A60_RS03625	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I1A60_RS03625	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I1A60_RS03625	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I1A60_RS03630	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I1A60_RS03635	COG1253	flavin adenine dinucleotide binding
I1A60_RS03640	COG0656	L-ascorbic acid biosynthetic process
I1A60_RS03645	COG0463	Glycosyl transferase, family 2
I1A60_RS03680	COG0720	synthase
I1A60_RS03690	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I1A60_RS03690	COG0512	Glutamine amidotransferase of anthranilate synthase
I1A60_RS03695	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I1A60_RS03725	COG0488	(ABC) transporter
I1A60_RS03730	COG0514	ATP-dependent DNA helicase (RecQ)
I1A60_RS03735	COG0517	IMP dehydrogenase activity
I1A60_RS03735	COG1125	glycine betaine transport
I1A60_RS03740	COG1174	glycine betaine transport
I1A60_RS03765	COG3104	oligopeptide transport
I1A60_RS03785	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I1A60_RS03790	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I1A60_RS03800	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I1A60_RS03805	COG4605	iron ion homeostasis
I1A60_RS03810	COG4604	ABC transporter, ATP-binding protein
I1A60_RS03815	COG4607	ABC-type enterochelin transport system periplasmic component
I1A60_RS03870	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I1A60_RS03875	COG1739	Uncharacterized protein family UPF0029
I1A60_RS03885	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I1A60_RS03890	COG1040	competence protein
I1A60_RS03920	COG3942	CHAP domain
I1A60_RS03920	COG1388	LysM domain
I1A60_RS03980	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I1A60_RS04040	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I1A60_RS04045	COG1647	Serine aminopeptidase, S33
I1A60_RS04050	COG0557	exoribonuclease II activity
I1A60_RS04120	COG1278	Cold shock
I1A60_RS04160	COG0406	alpha-ribazole phosphatase activity
I1A60_RS04165	COG1279	arginine transmembrane transporter activity
I1A60_RS04190	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I1A60_RS04195	COG1393	Belongs to the ArsC family
I1A60_RS04210	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I1A60_RS04225	COG2011	ABC-type metal ion transport system permease component
I1A60_RS04230	COG1464	Belongs to the NlpA lipoprotein family
I1A60_RS04245	COG0396	ATPase activity
I1A60_RS04250	COG0719	Fe-S assembly protein
I1A60_RS04260	COG0822	iron-sulfur transferase activity
I1A60_RS04280	COG1253	flavin adenine dinucleotide binding
I1A60_RS04295	COG1801	Protein of unknown function DUF72
I1A60_RS04300	COG0730	response to heat
I1A60_RS04315	COG4470	Protein conserved in bacteria
I1A60_RS04325	COG2445	Protein of unknown function DUF86
I1A60_RS04355	COG1696	Membrane protein involved in D-alanine export
I1A60_RS04365	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I1A60_RS04370	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I1A60_RS04375	COG4837	Protein of unknown function (DUF1462)
I1A60_RS04380	COG1252	NADH dehydrogenase
I1A60_RS04390	COG0316	Belongs to the HesB IscA family
I1A60_RS04400	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I1A60_RS04405	COG2056	Na+-H+ antiporter family
I1A60_RS04410	COG2050	protein possibly involved in aromatic compounds catabolism
I1A60_RS04465	COG1098	S1 RNA binding domain
I1A60_RS04470	COG1902	pentaerythritol trinitrate reductase activity
I1A60_RS04485	COG0584	glycerophosphoryl diester phosphodiesterase
I1A60_RS04505	COG0398	Pfam SNARE associated Golgi protein
I1A60_RS04550	COG0561	phosphatase activity
I1A60_RS04590	COG1881	PFAM PEBP family protein
I1A60_RS04620	COG0601	transmembrane transport
I1A60_RS04625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I1A60_RS04630	COG0444	Belongs to the ABC transporter superfamily
I1A60_RS04635	COG4608	Belongs to the ABC transporter superfamily
I1A60_RS04640	COG4166	transmembrane transport
I1A60_RS04645	COG0747	negative chemotaxis
I1A60_RS04650	COG0444	Belongs to the ABC transporter superfamily
I1A60_RS04655	COG4608	Belongs to the ABC transporter superfamily
I1A60_RS04660	COG0601	transmembrane transport
I1A60_RS04665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I1A60_RS04690	COG1164	Oligoendopeptidase f
I1A60_RS04700	COG2346	COG2346, Truncated hemoglobins
I1A60_RS04715	COG2357	RelA SpoT domain protein
I1A60_RS04725	COG0564	pseudouridine synthase activity
I1A60_RS04730	COG2239	Acts as a magnesium transporter
I1A60_RS04735	COG0475	glutathione-regulated potassium exporter activity
I1A60_RS04735	COG0569	domain protein
I1A60_RS04745	COG0628	permease
I1A60_RS04750	COG1115	amino acid carrier protein
I1A60_RS04790	COG0861	Integral membrane protein TerC family
I1A60_RS04800	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I1A60_RS04805	COG0737	Belongs to the 5'-nucleotidase family
I1A60_RS04820	COG4903	ComK protein
I1A60_RS04835	COG4873	Protein conserved in bacteria
I1A60_RS04890	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I1A60_RS04900	COG2314	TM2 domain
I1A60_RS04905	COG0456	acetyltransferase
I1A60_RS04910	COG1575	Belongs to the MenA family. Type 1 subfamily
I1A60_RS04915	COG1169	isochorismate synthase
I1A60_RS04925	COG2267	carboxylic ester hydrolase activity
I1A60_RS04950	COG0436	Aminotransferase
I1A60_RS04955	COG3594	Acyltransferase
I1A60_RS04985	COG1316	TRANSCRIPTIONal
I1A60_RS04990	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I1A60_RS05030	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I1A60_RS05045	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I1A60_RS05085	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I1A60_RS05090	COG4172	Belongs to the ABC transporter superfamily
I1A60_RS05095	COG4721	ABC-type cobalt transport system, permease component
I1A60_RS05110	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I1A60_RS05130	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I1A60_RS05135	COG1271	oxidase subunit
I1A60_RS05140	COG1294	oxidase, subunit
I1A60_RS05145	COG0569	domain protein
I1A60_RS05210	COG1176	ABC-type spermidine putrescine transport system, permease component I
I1A60_RS05215	COG1177	transmembrane transport
I1A60_RS05220	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I1A60_RS05245	COG0483	inositol monophosphate 1-phosphatase activity
I1A60_RS05255	COG1217	gtp-binding protein TYPA
I1A60_RS05265	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I1A60_RS05275	COG0772	Belongs to the SEDS family
I1A60_RS05305	COG3679	Belongs to the UPF0342 family
I1A60_RS05325	COG0742	ribosomal rna small subunit methyltransferase
I1A60_RS05380	COG4509	Sortase family
I1A60_RS05395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I1A60_RS05425	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I1A60_RS05425	COG1796	DNA polymerase
I1A60_RS05450	COG2009	succinate dehydrogenase
I1A60_RS05455	COG1053	succinate dehydrogenase
I1A60_RS05460	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I1A60_RS05570	COG1288	antiporter activity
I1A60_RS05610	COG1011	Hydrolase
I1A60_RS05635	COG4839	cell division protein FtsL
I1A60_RS05640	COG0768	penicillin binding
I1A60_RS05655	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I1A60_RS05660	COG0849	cell division
I1A60_RS05675	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I1A60_RS05685	COG0762	integral membrane protein
I1A60_RS05695	COG3599	regulation of cell shape
I1A60_RS05705	COG2514	catechol 2,3-dioxygenase activity
I1A60_RS05720	COG0564	pseudouridine synthase activity
I1A60_RS05730	COG2233	PERMEase
I1A60_RS05775	COG1293	RNA-binding protein homologous to eukaryotic snRNP
I1A60_RS05790	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I1A60_RS05795	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I1A60_RS05805	COG2314	TM2 domain
I1A60_RS05820	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I1A60_RS05820	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I1A60_RS05830	COG0631	protein serine/threonine phosphatase activity
I1A60_RS05845	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I1A60_RS05860	COG1302	Protein conserved in bacteria
I1A60_RS05905	COG1196	nuclear chromosome segregation
I1A60_RS05910	COG0552	protein localization to endoplasmic reticulum
I1A60_RS05920	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I1A60_RS05970	COG0758	DNA mediated transformation
I1A60_RS06065	COG0195	Participates in both transcription termination and antitermination
I1A60_RS06070	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I1A60_RS06095	COG0196	riboflavin kinase activity
I1A60_RS06120	COG2188	Transcriptional regulator
I1A60_RS06125	COG0612	Peptidase, M16
I1A60_RS06130	COG0612	Peptidase, M16
I1A60_RS06135	COG0300	oxidoreductase activity
I1A60_RS06155	COG1058	Belongs to the CinA family
I1A60_RS06155	COG1546	Belongs to the CinA family
I1A60_RS06175	COG1692	metallophosphoesterase
I1A60_RS06180	COG0674	pyruvate-flavodoxin oxidoreductase activity
I1A60_RS06180	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I1A60_RS06185	COG1013	pyruvate-flavodoxin oxidoreductase activity
I1A60_RS06220	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I1A60_RS06225	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I1A60_RS06250	COG1923	regulation of RNA biosynthetic process
I1A60_RS06260	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I1A60_RS06265	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
I1A60_RS06270	COG0789	Transcriptional regulator
I1A60_RS06380	COG1131	(ABC) transporter
I1A60_RS06395	COG2197	response regulator
I1A60_RS06405	COG1525	nuclease
I1A60_RS06420	COG0527	aspartate kinase activity
I1A60_RS06425	COG0460	homoserine dehydrogenase
I1A60_RS06430	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I1A60_RS06455	COG0833	amino acid
I1A60_RS06480	COG2340	Cysteine-rich secretory protein family
I1A60_RS06515	COG4846	Membrane protein involved in cytochrome C biogenesis
I1A60_RS06535	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I1A60_RS06545	COG0824	Thioesterase
I1A60_RS06565	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I1A60_RS06570	COG1115	amino acid carrier protein
I1A60_RS06585	COG0628	permease
I1A60_RS06610	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I1A60_RS06620	COG1363	Peptidase, m42
I1A60_RS06625	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I1A60_RS06630	COG0512	Glutamine amidotransferase of anthranilate synthase
I1A60_RS06670	COG0561	phosphatase activity
I1A60_RS06715	COG0704	Plays a role in the regulation of phosphate uptake
I1A60_RS06725	COG0581	inorganic phosphate transmembrane transporter activity
I1A60_RS06730	COG0573	inorganic phosphate transmembrane transporter activity
I1A60_RS06750	COG0488	(ABC) transporter
I1A60_RS06755	COG0527	aspartate kinase activity
I1A60_RS06760	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I1A60_RS06835	COG4548	von Willebrand factor, type A
I1A60_RS06840	COG0714	Associated with various cellular activities
I1A60_RS06885	COG0671	phosphoesterase, PA-phosphatase related
I1A60_RS06945	COG1413	lyase activity
I1A60_RS06960	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I1A60_RS06985	COG0531	amino acid
I1A60_RS07000	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I1A60_RS07005	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I1A60_RS07020	COG0116	Belongs to the methyltransferase superfamily
I1A60_RS07055	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I1A60_RS07055	COG4499	WXG100 protein secretion system (Wss), protein YukC
I1A60_RS07065	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I1A60_RS07070	COG3935	DnaD domain protein
I1A60_RS07095	COG0438	transferase activity, transferring glycosyl groups
I1A60_RS07100	COG1694	Mazg nucleotide pyrophosphohydrolase
I1A60_RS07105	COG2738	Putative neutral zinc metallopeptidase
I1A60_RS07110	COG4347	Protein of unknown function (DUF1405)
I1A60_RS07115	COG5582	Belongs to the UPF0302 family
I1A60_RS07150	COG0142	geranyltranstransferase activity
I1A60_RS07205	COG0492	ferredoxin-NADP+ reductase activity
I1A60_RS07220	COG0514	ATP-dependent DNA helicase (RecQ)
I1A60_RS07230	COG1141	Ferredoxin
I1A60_RS07275	COG0860	N-Acetylmuramoyl-L-alanine amidase
I1A60_RS07275	COG1388	LysM domain
I1A60_RS07600	COG5002	protein histidine kinase activity
I1A60_RS07605	COG0745	RESPONSE REGULATOR receiver
I1A60_RS07610	COG1187	pseudouridine synthase activity
I1A60_RS07635	COG0735	belongs to the Fur family
I1A60_RS07640	COG0494	nUDIX hydrolase
I1A60_RS07645	COG0667	Aldo Keto reductase
I1A60_RS07655	COG4221	oxidoreductase activity
I1A60_RS07670	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I1A60_RS07680	COG0366	Alpha amylase catalytic
I1A60_RS07685	COG1609	Transcriptional regulator
I1A60_RS07710	COG2195	Cleaves the N-terminal amino acid of tripeptides
I1A60_RS07720	COG4129	membrane
I1A60_RS07730	COG0508	dehydrogenase complex catalyzes the overall conversion of
I1A60_RS07735	COG0022	dehydrogenase e1 component
I1A60_RS07740	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I1A60_RS07745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I1A60_RS07750	COG0497	DNA recombination
I1A60_RS07780	COG1302	Protein conserved in bacteria
I1A60_RS07785	COG0439	Biotin carboxylase
I1A60_RS07790	COG0511	ligase activity, forming carbon-carbon bonds
I1A60_RS07800	COG0006	proline dipeptidase activity
I1A60_RS07815	COG0095	Lipoate-protein ligase
I1A60_RS07820	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I1A60_RS07865	COG4537	Required for transformation and DNA binding
I1A60_RS07870	COG1459	type II secretion system
I1A60_RS07875	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I1A60_RS07880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I1A60_RS07885	COG0011	TIGRFAM Protein of
I1A60_RS07890	COG1940	carbohydrate kinase activity
I1A60_RS07895	COG4483	Protein conserved in bacteria
I1A60_RS07905	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I1A60_RS07915	COG0768	penicillin binding
I1A60_RS07930	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I1A60_RS07935	COG1121	(ABC) transporter
I1A60_RS07945	COG0513	Belongs to the DEAD box helicase family
I1A60_RS07955	COG2384	SAM-dependent methyltransferase
I1A60_RS07975	COG0517	IMP dehydrogenase activity
I1A60_RS07995	COG0295	cytidine deaminase activity
I1A60_RS08010	COG1702	phosphate starvation-inducible protein PhoH
I1A60_RS08025	COG1030	water channel activity
I1A60_RS08035	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I1A60_RS08040	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I1A60_RS08070	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I1A60_RS08085	COG1466	dna polymerase III delta subunit
I1A60_RS08090	COG0658	competence protein
I1A60_RS08090	COG2333	competence protein COMEC
I1A60_RS08095	COG2131	deaminase
I1A60_RS08105	COG2226	methyltransferase
I1A60_RS08110	COG0799	negative regulation of ribosome biogenesis
I1A60_RS08115	COG1713	HD superfamily hydrolase involved in NAD metabolism
I1A60_RS08125	COG1534	Rna-binding protein
I1A60_RS08135	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I1A60_RS08140	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I1A60_RS08165	COG1914	H( )-stimulated, divalent metal cation uptake system
I1A60_RS08175	COG0439	Biotin carboxylase
I1A60_RS08180	COG0511	ligase activity, forming carbon-carbon bonds
I1A60_RS08185	COG1984	allophanate hydrolase subunit 2
I1A60_RS08190	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I1A60_RS08205	COG0826	peptidase U32
I1A60_RS08210	COG0826	peptidase U32
I1A60_RS08240	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I1A60_RS08255	COG1104	cysteine desulfurase activity
I1A60_RS08260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I1A60_RS08270	COG3237	CsbD-like
I1A60_RS08275	COG1959	2 iron, 2 sulfur cluster binding
I1A60_RS08280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I1A60_RS08285	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I1A60_RS08330	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I1A60_RS08330	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I1A60_RS08335	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I1A60_RS08335	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I1A60_RS08340	COG1862	Preprotein translocase
I1A60_RS08380	COG2868	ribosomal protein
I1A60_RS08425	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I1A60_RS08430	COG0285	dihydrofolate synthase activity
I1A60_RS08440	COG2818	Glycosylase
I1A60_RS08475	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I1A60_RS08510	COG4112	unkown
I1A60_RS08530	COG0833	amino acid
I1A60_RS08545	COG1484	DNA-dependent DNA replication
I1A60_RS08575	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I1A60_RS08575	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I1A60_RS08585	COG5002	protein histidine kinase activity
I1A60_RS08590	COG0745	RESPONSE REGULATOR receiver
I1A60_RS08600	COG0372	Belongs to the citrate synthase family
I1A60_RS08605	COG1113	amino acid transport
I1A60_RS08630	COG0281	malic enzyme
I1A60_RS08640	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I1A60_RS08645	COG4109	DRTGG domain
I1A60_RS08685	COG0827	DNA restriction-modification system
I1A60_RS08705	COG1104	cysteine desulfurase activity
I1A60_RS08720	COG1956	GAF domain-containing protein
I1A60_RS08730	COG0584	glycerophosphoryl diester phosphodiesterase
I1A60_RS08735	COG1764	response to oxidative stress
I1A60_RS08740	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I1A60_RS08745	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I1A60_RS08760	COG1263	PTS System
I1A60_RS08760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I1A60_RS08765	COG0204	Acyl-transferase
I1A60_RS08770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I1A60_RS08790	COG5386	Cell surface protein
I1A60_RS08800	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I1A60_RS08805	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I1A60_RS08810	COG0454	-acetyltransferase
I1A60_RS08830	COG1605	Chorismate mutase
I1A60_RS08830	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I1A60_RS08855	COG1674	ftsk spoiiie
I1A60_RS08860	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I1A60_RS08870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I1A60_RS08875	COG1363	Peptidase, m42
I1A60_RS08885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I1A60_RS08895	COG0510	thiamine kinase activity
I1A60_RS08915	COG1187	pseudouridine synthase activity
I1A60_RS08920	COG2244	polysaccharide biosynthetic process
I1A60_RS08945	COG2814	Major facilitator Superfamily
I1A60_RS08950	COG1242	4 iron, 4 sulfur cluster binding
I1A60_RS08955	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I1A60_RS08970	COG2267	carboxylic ester hydrolase activity
I1A60_RS09000	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I1A60_RS09000	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I1A60_RS09025	COG3266	domain, Protein
I1A60_RS09025	COG5632	N-Acetylmuramoyl-L-alanine amidase
I1A60_RS09025	COG4193	domain, Protein
I1A60_RS09055	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I1A60_RS09075	COG0656	L-ascorbic acid biosynthetic process
I1A60_RS09095	COG1506	peptidase
I1A60_RS09100	COG2816	NAD+ diphosphatase activity
I1A60_RS09265	COG1131	(ABC) transporter
I1A60_RS09310	COG2856	Zn peptidase
I1A60_RS09340	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I1A60_RS09340	COG0551	DNA topoisomerase type I activity
I1A60_RS09520	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I1A60_RS09550	COG1131	(ABC) transporter
I1A60_RS09555	COG0537	adenosine 5'-monophosphoramidase activity
I1A60_RS09585	COG0420	3'-5' exonuclease activity
I1A60_RS09610	COG2197	response regulator
I1A60_RS09615	COG4585	Histidine kinase
I1A60_RS09615	COG2203	Gaf domain
I1A60_RS09620	COG0564	pseudouridine synthase activity
I1A60_RS09650	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I1A60_RS09655	COG1126	abc transporter atp-binding protein
I1A60_RS09660	COG0765	amino acid transport
I1A60_RS09835	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I1A60_RS09840	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I1A60_RS09850	COG4129	membrane
I1A60_RS09870	COG1194	a g-specific adenine glycosylase
I1A60_RS09875	COG1988	membrane-bound metal-dependent
I1A60_RS09885	COG1388	LysM domain
I1A60_RS09885	COG1134	teichoic acid transport
I1A60_RS09915	COG0535	radical SAM domain protein
I1A60_RS09920	COG1607	acyl-coa hydrolase
I1A60_RS09925	COG2309	aminopeptidase activity
I1A60_RS09945	COG1295	ribonuclease BN
I1A60_RS09950	COG2197	response regulator
I1A60_RS10060	COG4851	CamS sex pheromone cAM373 precursor
I1A60_RS10080	COG4496	protein, YerC YecD
I1A60_RS10115	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I1A60_RS10125	COG0077	Prephenate dehydratase
I1A60_RS10135	COG0471	metal ion transport
I1A60_RS10145	COG1335	isochorismatase
I1A60_RS10160	COG1012	belongs to the aldehyde dehydrogenase family
I1A60_RS10215	COG1131	(ABC) transporter
I1A60_RS10230	COG1725	Transcriptional regulator
I1A60_RS10290	COG5632	N-Acetylmuramoyl-L-alanine amidase
I1A60_RS10290	COG1388	LysM domain
I1A60_RS10350	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I1A60_RS10355	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I1A60_RS10360	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I1A60_RS10435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I1A60_RS10440	COG1621	beta-fructofuranosidase activity
I1A60_RS10445	COG1609	Transcriptional regulator
I1A60_RS10450	COG0004	ammonium transporteR
I1A60_RS10455	COG0425	Belongs to the sulfur carrier protein TusA family
I1A60_RS10460	COG2391	methyltransferase activity
I1A60_RS10470	COG0488	(ABC) transporter
I1A60_RS10480	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I1A60_RS10490	COG0456	acetyltransferase
I1A60_RS10495	COG1214	PFAM Peptidase M22, glycoprotease
I1A60_RS10500	COG0802	atpase or kinase
I1A60_RS10515	COG0028	Belongs to the TPP enzyme family
I1A60_RS10585	COG2183	response to ionizing radiation
I1A60_RS10590	COG1191	sigma factor activity
I1A60_RS10600	COG1366	Belongs to the anti-sigma-factor antagonist family
I1A60_RS10605	COG2208	phosphoserine phosphatase activity
I1A60_RS10635	COG3428	Bacterial PH domain
I1A60_RS10665	COG2205	protein histidine kinase activity
I1A60_RS10670	COG0745	RESPONSE REGULATOR receiver
I1A60_RS10680	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I1A60_RS10690	COG0772	Belongs to the SEDS family
I1A60_RS10705	COG1937	Protein conserved in bacteria
I1A60_RS10715	COG1418	mRNA catabolic process
I1A60_RS10750	COG0629	single-stranded DNA binding
I1A60_RS10825	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I1A60_RS10850	COG0009	L-threonylcarbamoyladenylate synthase
I1A60_RS10855	COG2890	protein-(glutamine-N5) methyltransferase activity
I1A60_RS10875	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I1A60_RS10915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I1A60_RS10960	COG0813	purine-nucleoside phosphorylase activity
I1A60_RS10965	COG0783	Belongs to the Dps family
I1A60_RS10985	COG1482	cell wall glycoprotein biosynthetic process
I1A60_RS10990	COG0702	epimerase
I1A60_RS10995	COG0640	Transcriptional regulator
I1A60_RS11025	COG0561	phosphatase activity
I1A60_RS11030	COG1119	ATPase activity
I1A60_RS11075	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I1A60_RS11145	COG0489	protein tyrosine kinase activity
I1A60_RS11150	COG2814	Major facilitator Superfamily
I1A60_RS11165	COG1272	protein, Hemolysin III
I1A60_RS11175	COG1988	membrane-bound metal-dependent
I1A60_RS11185	COG3314	Sporulation integral membrane protein YlbJ
I1A60_RS11190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I1A60_RS11195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I1A60_RS11200	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I1A60_RS11210	COG3457	Alanine racemase
I1A60_RS11215	COG4264	IucA IucC family
I1A60_RS11220	COG2814	Major facilitator Superfamily
I1A60_RS11245	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I1A60_RS11255	COG2130	NADP-dependent
I1A60_RS11320	COG0656	L-ascorbic acid biosynthetic process
I1A60_RS11325	COG0789	Transcriptional regulator
I1A60_RS11335	COG5492	domain, Protein
I1A60_RS11345	COG3527	Alpha-acetolactate decarboxylase
I1A60_RS11350	COG0028	Belongs to the TPP enzyme family
I1A60_RS11430	COG0201	protein transport
I1A60_RS11545	COG2252	PERMEase
I1A60_RS11590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I1A60_RS11650	COG1763	Mo-molybdopterin cofactor biosynthetic process
I1A60_RS11670	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I1A60_RS11675	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I1A60_RS11680	COG4149	molybdate abc transporter
I1A60_RS11685	COG0725	ABC transporter, periplasmic molybdate-binding protein
I1A60_RS11700	COG1268	BioY protein
I1A60_RS11715	COG1960	acyl-CoA dehydrogenase activity
I1A60_RS11720	COG4413	Urea transporter
I1A60_RS11790	COG1757	Na H antiporter
I1A60_RS11805	COG3942	CHAP domain
I1A60_RS11875	COG1113	amino acid transport
I1A60_RS11895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I1A60_RS11900	COG0385	Bile acid
I1A60_RS11910	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I1A60_RS11910	COG1263	PTS System
I1A60_RS11915	COG1737	Transcriptional regulator
I1A60_RS11935	COG1028	Short-chain dehydrogenase reductase Sdr
I1A60_RS11940	COG1473	amidohydrolase
I1A60_RS11955	COG0583	DNA-binding transcription factor activity
I1A60_RS11975	COG2258	MOSC domain
I1A60_RS11995	COG1668	transmembrane transport
I1A60_RS12000	COG4152	abc transporter atp-binding protein
I1A60_RS12005	COG3152	Membrane
I1A60_RS12015	COG0786	glutamate:sodium symporter activity
I1A60_RS12025	COG0598	Magnesium transport protein CorA
I1A60_RS12040	COG0657	acetylesterase activity
I1A60_RS12050	COG2814	Major facilitator Superfamily
I1A60_RS12055	COG1566	PFAM secretion protein HlyD family protein
I1A60_RS12065	COG2814	Major facilitator Superfamily
I1A60_RS12125	COG1620	l-lactate permease
I1A60_RS12145	COG0604	alcohol dehydrogenase
I1A60_RS12170	COG1511	domain protein
I1A60_RS12185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I1A60_RS12185	COG1263	PTS System
I1A60_RS12200	COG3871	stress protein (general stress protein 26)
I1A60_RS12250	COG2181	nitrate reductase activity
I1A60_RS12265	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I1A60_RS12275	COG2146	nitrite reductase [NAD(P)H] activity
I1A60_RS12280	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I1A60_RS12290	COG0454	-acetyltransferase
I1A60_RS12300	COG2116	formate transmembrane transporter activity
I1A60_RS12315	COG3443	Belongs to the bacterial solute-binding protein 9 family
I1A60_RS12315	COG0803	Belongs to the bacterial solute-binding protein 9 family
I1A60_RS12355	COG1126	abc transporter atp-binding protein
I1A60_RS12360	COG0765	amino acid transport
I1A60_RS12365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I1A60_RS12370	COG2814	Major facilitator Superfamily
I1A60_RS12385	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I1A60_RS12425	COG0156	8-amino-7-oxononanoate synthase activity
I1A60_RS12435	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I1A60_RS12440	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I1A60_RS12450	COG1132	(ABC) transporter
I1A60_RS12455	COG2375	cellular response to nickel ion
I1A60_RS12455	COG1132	(ABC) transporter
I1A60_RS12470	COG1929	Belongs to the glycerate kinase type-1 family
I1A60_RS12480	COG2814	Major facilitator Superfamily
I1A60_RS12500	COG1113	amino acid transport
I1A60_RS12510	COG0531	amino acid
I1A60_RS12525	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I1A60_RS12535	COG1174	glycine betaine transport
I1A60_RS12545	COG1174	glycine betaine transport
I1A60_RS12565	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
I1A60_RS12570	COG0531	amino acid
I1A60_RS12580	COG2272	Belongs to the type-B carboxylesterase lipase family
I1A60_RS12585	COG2814	Major facilitator Superfamily
I1A60_RS12590	COG0390	transport system, permease component
I1A60_RS12595	COG4619	ABC transporter
I1A60_RS12600	COG1363	Peptidase, m42
I1A60_RS12615	COG4808	Protein conserved in bacteria
I1A60_RS12620	COG0069	glutamate synthase activity
I1A60_RS12635	COG1124	(ABC) transporter
I1A60_RS12640	COG0444	Belongs to the ABC transporter superfamily
I1A60_RS12645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I1A60_RS12650	COG0601	transmembrane transport
I1A60_RS12680	COG1028	Short-chain dehydrogenase reductase Sdr
I1A60_RS12685	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I1A60_RS12690	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I1A60_RS12760	COG0494	nUDIX hydrolase
I1A60_RS12800	COG1846	Transcriptional regulator
I1A60_RS12830	COG1070	Carbohydrate kinase
I1A60_RS12835	COG1802	Transcriptional regulator
I1A60_RS12840	COG0789	Transcriptional regulator
I1A60_RS12845	COG2357	RelA SpoT domain protein
I1A60_RS12850	COG4876	unkown
I1A60_RS12860	COG2271	Major facilitator Superfamily
I1A60_RS12865	COG0586	Pfam SNARE associated Golgi protein
I1A60_RS12875	COG2814	Major facilitator Superfamily
I1A60_RS12880	COG1846	Transcriptional regulator
I1A60_RS12885	COG1131	(ABC) transporter
I1A60_RS12900	COG3949	Membrane
I1A60_RS12910	COG0346	lactoylglutathione lyase activity
I1A60_RS12915	COG1846	Transcriptional regulator
I1A60_RS12925	COG2514	catechol 2,3-dioxygenase activity
I1A60_RS12940	COG0561	phosphatase activity
I1A60_RS12945	COG1131	(ABC) transporter
I1A60_RS12955	COG3764	Sortase (surface protein transpeptidase)
I1A60_RS12970	COG1760	l-serine dehydratase
I1A60_RS12975	COG1760	l-serine dehydratase
I1A60_RS12990	COG0697	spore germination
I1A60_RS12995	COG0657	acetylesterase activity
I1A60_RS13015	COG0028	Belongs to the TPP enzyme family
I1A60_RS13030	COG0583	DNA-binding transcription factor activity
I1A60_RS13040	COG3942	CHAP domain
I1A60_RS13065	COG3425	synthase
I1A60_RS13070	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I1A60_RS13095	COG2409	Drug exporters of the RND superfamily
I1A60_RS13140	COG0436	Aminotransferase
I1A60_RS13170	COG3942	CHAP domain
I1A60_RS13175	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I1A60_RS13175	COG2755	lipolytic protein G-D-S-L family
I1A60_RS13240	COG0596	Alpha beta hydrolase
I1A60_RS13275	COG3001	Fructosamine kinase
I1A60_RS13280	COG0167	dihydroorotate dehydrogenase activity
I1A60_RS13330	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I1A60_RS13335	COG3527	Alpha-acetolactate decarboxylase
I1A60_RS13345	COG0531	amino acid
I1A60_RS13375	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I1A60_RS13395	COG1012	belongs to the aldehyde dehydrogenase family
I1A60_RS13405	COG1510	regulation of RNA biosynthetic process
I1A60_RS13415	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I1A60_RS13440	COG2851	Citrate transporter
I1A60_RS13455	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I1A60_RS13465	COG0386	Belongs to the glutathione peroxidase family
I1A60_RS13485	COG1136	(ABC) transporter
I1A60_RS13490	COG2205	protein histidine kinase activity
I1A60_RS13495	COG0745	RESPONSE REGULATOR receiver
I1A60_RS13515	COG1846	Transcriptional regulator
I1A60_RS13560	COG1438	arginine binding
I1A60_RS13580	COG3711	transcriptional antiterminator
I1A60_RS13580	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I1A60_RS13585	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I1A60_RS13585	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I1A60_RS13585	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I1A60_RS13590	COG1482	cell wall glycoprotein biosynthetic process
I1A60_RS13600	COG3942	CHAP domain
I1A60_RS13600	COG1705	Flagellar rod assembly protein muramidase FlgJ
I1A60_RS13605	COG1535	isochorismatase
I1A60_RS13605	COG3433	isochorismatase activity
I1A60_RS13620	COG0438	transferase activity, transferring glycosyl groups
I1A60_RS13635	COG1073	alpha beta
I1A60_RS13655	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I1A60_RS13675	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I1A60_RS13765	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I1A60_RS13850	COG0471	metal ion transport
I1A60_RS13855	COG2962	Rard protein
I1A60_RS13865	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
I1A60_RS13880	COG1136	(ABC) transporter
I1A60_RS13885	COG0577	efflux transmembrane transporter activity
I1A60_RS13895	COG1278	Cold shock
I1A60_RS13915	COG1475	DNA binding