locus-tag	class	description
HUW54_RS00015	COG2501	S4 domain
HUW54_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HUW54_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HUW54_RS00060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HUW54_RS00070	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HUW54_RS00080	COG0305	Participates in initiation and elongation during chromosome replication
HUW54_RS00110	COG4863	YycH protein
HUW54_RS00120	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HUW54_RS00125	COG0737	Belongs to the 5'-nucleotidase family
HUW54_RS00135	COG1002	Type II restriction enzyme, methylase subunits
HUW54_RS00140	COG1061	Type III restriction enzyme res subunit
HUW54_RS00145	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HUW54_RS00340	COG0747	negative chemotaxis
HUW54_RS00350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUW54_RS00355	COG4172	Belongs to the ABC transporter superfamily
HUW54_RS00485	COG0823	Involved in the tonB-independent uptake of proteins
HUW54_RS00525	COG1473	amidohydrolase
HUW54_RS00535	COG1283	sodium-dependent phosphate transmembrane transporter activity
HUW54_RS00540	COG4716	Myosin-crossreactive antigen
HUW54_RS00550	COG1620	l-lactate permease
HUW54_RS00565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUW54_RS00570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUW54_RS00575	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUW54_RS00585	COG2423	ornithine cyclodeaminase activity
HUW54_RS00590	COG4264	IucA IucC family
HUW54_RS00595	COG2814	Major facilitator Superfamily
HUW54_RS00600	COG4264	IucA IucC family
HUW54_RS00605	COG4264	IucA IucC family
HUW54_RS00615	COG0019	diaminopimelate decarboxylase activity
HUW54_RS00620	COG1475	DNA binding
HUW54_RS00640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUW54_RS00645	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HUW54_RS00650	COG0438	transferase activity, transferring glycosyl groups
HUW54_RS00680	COG0813	purine-nucleoside phosphorylase activity
HUW54_RS00685	COG2814	Major facilitator Superfamily
HUW54_RS00705	COG3639	organic phosphonate transmembrane transporter activity
HUW54_RS00725	COG0737	Belongs to the 5'-nucleotidase family
HUW54_RS00755	COG1454	alcohol dehydrogenase
HUW54_RS00755	COG1012	belongs to the aldehyde dehydrogenase family
HUW54_RS00780	COG1086	Polysaccharide biosynthesis protein
HUW54_RS00790	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HUW54_RS00820	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HUW54_RS00830	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HUW54_RS00835	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HUW54_RS00845	COG2832	Protein of unknown function (DUF454)
HUW54_RS00880	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUW54_RS00885	COG1960	acyl-CoA dehydrogenase activity
HUW54_RS00890	COG5609	conserved protein (DUF2294)
HUW54_RS00940	COG1114	Component of the transport system for branched-chain amino acids
HUW54_RS00945	COG1335	isochorismatase
HUW54_RS00950	COG3961	Belongs to the TPP enzyme family
HUW54_RS00980	COG1737	Transcriptional regulator
HUW54_RS01020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUW54_RS01030	COG0405	Gamma-glutamyltransferase
HUW54_RS01050	COG3842	ATPase activity
HUW54_RS01060	COG1175	transmembrane transport
HUW54_RS01065	COG3833	ABC-type maltose transport systems, permease component
HUW54_RS01070	COG0673	inositol 2-dehydrogenase activity
HUW54_RS01075	COG0673	inositol 2-dehydrogenase activity
HUW54_RS01085	COG1755	Isoprenylcysteine carboxyl methyltransferase
HUW54_RS01140	COG0183	Belongs to the thiolase family
HUW54_RS01150	COG1960	acyl-CoA dehydrogenase activity
HUW54_RS01155	COG0318	PFAM AMP-dependent synthetase and ligase
HUW54_RS01170	COG0747	negative chemotaxis
HUW54_RS01175	COG3189	MarR family transcriptional regulator
HUW54_RS01200	COG1263	PTS System
HUW54_RS01200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUW54_RS01200	COG2190	(PTS) system
HUW54_RS01205	COG1957	nucleoside hydrolase
HUW54_RS01225	COG3414	Phosphotransferase system galactitol-specific IIB component
HUW54_RS01230	COG3775	system Galactitol-specific IIC component
HUW54_RS01235	COG1063	alcohol dehydrogenase
HUW54_RS01245	COG1063	alcohol dehydrogenase
HUW54_RS01255	COG1063	alcohol dehydrogenase
HUW54_RS01260	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HUW54_RS01265	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HUW54_RS01275	COG1063	alcohol dehydrogenase
HUW54_RS01280	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HUW54_RS01315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUW54_RS01320	COG2190	(PTS) system
HUW54_RS01320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUW54_RS01320	COG1263	PTS System
HUW54_RS01330	COG2226	methyltransferase
HUW54_RS01390	COG1131	(ABC) transporter
HUW54_RS01410	COG3942	CHAP domain
HUW54_RS01410	COG1388	LysM domain
HUW54_RS01540	COG1114	Component of the transport system for branched-chain amino acids
HUW54_RS01545	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HUW54_RS01550	COG0577	efflux transmembrane transporter activity
HUW54_RS01575	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HUW54_RS01580	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUW54_RS01630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUW54_RS01660	COG3037	sugar-specific permease SgaT UlaA
HUW54_RS01670	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUW54_RS01675	COG3711	transcriptional antiterminator
HUW54_RS01695	COG2271	Major facilitator Superfamily
HUW54_RS01700	COG0346	lactoylglutathione lyase activity
HUW54_RS01705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUW54_RS01710	COG0431	NADPH-dependent FMN reductase
HUW54_RS01725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUW54_RS01730	COG2822	iron ion transport
HUW54_RS01740	COG0672	)-iron permease
HUW54_RS01745	COG0805	protein transport
HUW54_RS01750	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUW54_RS01760	COG1476	TRANSCRIPTIONal
HUW54_RS01770	COG1131	(ABC) transporter
HUW54_RS01800	COG0646	methionine synthase
HUW54_RS01800	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HUW54_RS01805	COG0626	cystathionine gamma-synthase activity
HUW54_RS01810	COG0626	cystathionine gamma-synthase activity
HUW54_RS01815	COG1475	DNA binding
HUW54_RS01820	COG0668	transmembrane transport
HUW54_RS01825	COG4481	Protein conserved in bacteria
HUW54_RS01830	COG0012	GTP binding
HUW54_RS01915	COG3634	alkyl hydroperoxide reductase activity
HUW54_RS01930	COG1823	symporter activity
HUW54_RS01960	COG2233	PERMEase
HUW54_RS02020	COG1683	Conserved Protein
HUW54_RS02030	COG3759	membrane
HUW54_RS02185	COG0523	cobalamin synthesis protein
HUW54_RS02215	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUW54_RS02225	COG5609	conserved protein (DUF2294)
HUW54_RS02240	COG1647	Serine aminopeptidase, S33
HUW54_RS02250	COG0733	neurotransmitter:sodium symporter activity
HUW54_RS02255	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HUW54_RS02260	COG0626	cystathionine gamma-synthase activity
HUW54_RS02270	COG2011	ABC-type metal ion transport system permease component
HUW54_RS02275	COG1464	Belongs to the NlpA lipoprotein family
HUW54_RS02310	COG0583	DNA-binding transcription factor activity
HUW54_RS02315	COG0067	glutamate synthase
HUW54_RS02315	COG0069	glutamate synthase activity
HUW54_RS02315	COG0070	glutamate synthase
HUW54_RS02320	COG0493	'glutamate synthase
HUW54_RS02330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUW54_RS02330	COG1263	PTS System
HUW54_RS02335	COG0366	Alpha amylase catalytic
HUW54_RS02340	COG2188	Transcriptional regulator
HUW54_RS02360	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HUW54_RS02395	COG1982	Orn Lys Arg decarboxylase major
HUW54_RS02405	COG3870	Protein conserved in bacteria
HUW54_RS02410	COG0470	DNA polymerase III
HUW54_RS02415	COG1774	PSP1 C-terminal conserved region
HUW54_RS02425	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HUW54_RS02435	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HUW54_RS02445	COG0084	hydrolase, TatD family'
HUW54_RS02450	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HUW54_RS02460	COG4466	Protein conserved in bacteria
HUW54_RS02470	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HUW54_RS02475	COG0251	oxidation-reduction process
HUW54_RS02515	COG2244	polysaccharide biosynthetic process
HUW54_RS02520	COG3956	TIGRFAM MazG family protein
HUW54_RS02525	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HUW54_RS02535	COG1098	S1 RNA binding domain
HUW54_RS02550	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUW54_RS02575	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HUW54_RS02670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUW54_RS02685	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HUW54_RS02695	COG3880	PFAM UvrB UvrC protein
HUW54_RS02710	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HUW54_RS02715	COG4956	integral membrane protein (PIN domain superfamily)
HUW54_RS02735	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HUW54_RS02790	COG2813	Specifically methylates the guanine in position
HUW54_RS02830	COG1473	amidohydrolase
HUW54_RS02860	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HUW54_RS02865	COG1428	Deoxynucleoside kinase
HUW54_RS02870	COG1428	Deoxynucleoside kinase
HUW54_RS02880	COG0561	phosphatase activity
HUW54_RS02920	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HUW54_RS03025	COG0095	Lipoate-protein ligase
HUW54_RS03030	COG0083	homoserine kinase activity
HUW54_RS03050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUW54_RS03095	COG0667	Aldo Keto reductase
HUW54_RS03100	COG0655	NAD(P)H dehydrogenase (quinone) activity
HUW54_RS03110	COG1078	dGTPase activity
HUW54_RS03145	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUW54_RS03150	COG4139	cobalamin transport
HUW54_RS03200	COG4974	Belongs to the 'phage' integrase family
HUW54_RS03245	COG0803	Belongs to the bacterial solute-binding protein 9 family
HUW54_RS03250	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HUW54_RS03255	COG1121	(ABC) transporter
HUW54_RS03260	COG1321	iron dependent repressor
HUW54_RS03270	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HUW54_RS03280	COG1682	transport, permease protein
HUW54_RS03285	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HUW54_RS03290	COG1216	Glycosyl transferase, family 2
HUW54_RS03295	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HUW54_RS03300	COG1686	Belongs to the peptidase S11 family
HUW54_RS03305	COG1132	(ABC) transporter
HUW54_RS03310	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HUW54_RS03320	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HUW54_RS03325	COG1120	ATPase activity
HUW54_RS03330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUW54_RS03335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUW54_RS03340	COG2376	Dihydroxyacetone kinase
HUW54_RS03350	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HUW54_RS03360	COG3949	Membrane
HUW54_RS03380	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUW54_RS03395	COG1136	(ABC) transporter
HUW54_RS03400	COG0577	efflux transmembrane transporter activity
HUW54_RS03405	COG1392	Phosphate transport regulator
HUW54_RS03410	COG0306	phosphate transporter
HUW54_RS03415	COG3942	CHAP domain
HUW54_RS03415	COG1388	LysM domain
HUW54_RS03425	COG1917	Cupin 2, conserved barrel domain protein
HUW54_RS03425	COG4977	sequence-specific DNA binding
HUW54_RS03455	COG0583	DNA-binding transcription factor activity
HUW54_RS03465	COG2814	Major facilitator Superfamily
HUW54_RS03470	COG2839	Protein conserved in bacteria
HUW54_RS03500	COG1611	Belongs to the LOG family
HUW54_RS03520	COG4988	ABC transporter
HUW54_RS03525	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HUW54_RS03535	COG0523	cobalamin synthesis protein
HUW54_RS03540	COG4989	oxidoreductase activity
HUW54_RS03550	COG0471	metal ion transport
HUW54_RS03585	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HUW54_RS03590	COG1349	DNA-binding transcription factor activity
HUW54_RS03595	COG1105	Belongs to the carbohydrate kinase PfkB family
HUW54_RS03600	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HUW54_RS03600	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUW54_RS03600	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HUW54_RS03605	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HUW54_RS03610	COG1253	flavin adenine dinucleotide binding
HUW54_RS03615	COG0656	L-ascorbic acid biosynthetic process
HUW54_RS03620	COG0463	Glycosyl transferase, family 2
HUW54_RS03655	COG0720	synthase
HUW54_RS03665	COG0512	Glutamine amidotransferase of anthranilate synthase
HUW54_RS03665	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HUW54_RS03670	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HUW54_RS03700	COG0488	(ABC) transporter
HUW54_RS03705	COG0514	ATP-dependent DNA helicase (RecQ)
HUW54_RS03710	COG1125	glycine betaine transport
HUW54_RS03710	COG0517	IMP dehydrogenase activity
HUW54_RS03715	COG1174	glycine betaine transport
HUW54_RS03740	COG3104	oligopeptide transport
HUW54_RS03760	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUW54_RS03765	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUW54_RS03775	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUW54_RS03780	COG4605	iron ion homeostasis
HUW54_RS03785	COG4604	ABC transporter, ATP-binding protein
HUW54_RS03790	COG4607	ABC-type enterochelin transport system periplasmic component
HUW54_RS03845	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HUW54_RS03850	COG1739	Uncharacterized protein family UPF0029
HUW54_RS03860	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HUW54_RS03865	COG1040	competence protein
HUW54_RS03895	COG3942	CHAP domain
HUW54_RS03895	COG1388	LysM domain
HUW54_RS03950	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HUW54_RS04010	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HUW54_RS04015	COG1647	Serine aminopeptidase, S33
HUW54_RS04020	COG0557	exoribonuclease II activity
HUW54_RS04080	COG1278	Cold shock
HUW54_RS04120	COG0406	alpha-ribazole phosphatase activity
HUW54_RS04125	COG1279	arginine transmembrane transporter activity
HUW54_RS04150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUW54_RS04155	COG1393	Belongs to the ArsC family
HUW54_RS04165	COG3878	Protein conserved in bacteria
HUW54_RS04170	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HUW54_RS04185	COG2011	ABC-type metal ion transport system permease component
HUW54_RS04190	COG1464	Belongs to the NlpA lipoprotein family
HUW54_RS04205	COG0396	ATPase activity
HUW54_RS04210	COG0719	Fe-S assembly protein
HUW54_RS04220	COG0822	iron-sulfur transferase activity
HUW54_RS04240	COG1253	flavin adenine dinucleotide binding
HUW54_RS04250	COG1801	Protein of unknown function DUF72
HUW54_RS04255	COG0730	response to heat
HUW54_RS04270	COG4470	Protein conserved in bacteria
HUW54_RS04280	COG2445	Protein of unknown function DUF86
HUW54_RS04310	COG1696	Membrane protein involved in D-alanine export
HUW54_RS04320	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HUW54_RS04325	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HUW54_RS04330	COG4837	Protein of unknown function (DUF1462)
HUW54_RS04335	COG1252	NADH dehydrogenase
HUW54_RS04345	COG0316	Belongs to the HesB IscA family
HUW54_RS04355	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HUW54_RS04360	COG2056	Na+-H+ antiporter family
HUW54_RS04365	COG2050	protein possibly involved in aromatic compounds catabolism
HUW54_RS04420	COG1098	S1 RNA binding domain
HUW54_RS04425	COG1902	pentaerythritol trinitrate reductase activity
HUW54_RS04440	COG0584	glycerophosphoryl diester phosphodiesterase
HUW54_RS04460	COG0398	Pfam SNARE associated Golgi protein
HUW54_RS04505	COG0561	phosphatase activity
HUW54_RS04530	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUW54_RS04545	COG1881	PFAM PEBP family protein
HUW54_RS04575	COG0601	transmembrane transport
HUW54_RS04580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUW54_RS04585	COG0444	Belongs to the ABC transporter superfamily
HUW54_RS04590	COG4608	Belongs to the ABC transporter superfamily
HUW54_RS04595	COG4166	transmembrane transport
HUW54_RS04600	COG0747	negative chemotaxis
HUW54_RS04605	COG0444	Belongs to the ABC transporter superfamily
HUW54_RS04610	COG4608	Belongs to the ABC transporter superfamily
HUW54_RS04615	COG0601	transmembrane transport
HUW54_RS04620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUW54_RS04645	COG1164	Oligoendopeptidase f
HUW54_RS04655	COG2346	COG2346, Truncated hemoglobins
HUW54_RS04670	COG2357	RelA SpoT domain protein
HUW54_RS04680	COG0564	pseudouridine synthase activity
HUW54_RS04685	COG2239	Acts as a magnesium transporter
HUW54_RS04690	COG0475	glutathione-regulated potassium exporter activity
HUW54_RS04690	COG0569	domain protein
HUW54_RS04700	COG0628	permease
HUW54_RS04705	COG1115	amino acid carrier protein
HUW54_RS04745	COG0861	Integral membrane protein TerC family
HUW54_RS04755	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HUW54_RS04760	COG0737	Belongs to the 5'-nucleotidase family
HUW54_RS04775	COG4903	ComK protein
HUW54_RS04790	COG4873	Protein conserved in bacteria
HUW54_RS04850	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HUW54_RS04860	COG2314	TM2 domain
HUW54_RS04865	COG0456	acetyltransferase
HUW54_RS04870	COG1575	Belongs to the MenA family. Type 1 subfamily
HUW54_RS04875	COG1169	isochorismate synthase
HUW54_RS04885	COG2267	carboxylic ester hydrolase activity
HUW54_RS04910	COG0436	Aminotransferase
HUW54_RS04915	COG3594	Acyltransferase
HUW54_RS04945	COG1316	TRANSCRIPTIONal
HUW54_RS04950	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HUW54_RS04990	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HUW54_RS05005	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUW54_RS05045	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HUW54_RS05050	COG4172	Belongs to the ABC transporter superfamily
HUW54_RS05055	COG4721	ABC-type cobalt transport system, permease component
HUW54_RS05070	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HUW54_RS05095	COG1271	oxidase subunit
HUW54_RS05100	COG1294	oxidase, subunit
HUW54_RS05105	COG0569	domain protein
HUW54_RS05170	COG1176	ABC-type spermidine putrescine transport system, permease component I
HUW54_RS05175	COG1177	transmembrane transport
HUW54_RS05180	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HUW54_RS05205	COG0483	inositol monophosphate 1-phosphatase activity
HUW54_RS05225	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HUW54_RS05235	COG0772	Belongs to the SEDS family
HUW54_RS05265	COG3679	Belongs to the UPF0342 family
HUW54_RS05285	COG0742	ribosomal rna small subunit methyltransferase
HUW54_RS05340	COG4509	Sortase family
HUW54_RS05355	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUW54_RS05385	COG1796	DNA polymerase
HUW54_RS05385	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HUW54_RS05410	COG2009	succinate dehydrogenase
HUW54_RS05415	COG1053	succinate dehydrogenase
HUW54_RS05420	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HUW54_RS05540	COG1011	Hydrolase
HUW54_RS05565	COG4839	cell division protein FtsL
HUW54_RS05585	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HUW54_RS05590	COG0849	cell division
HUW54_RS05605	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HUW54_RS05615	COG0762	integral membrane protein
HUW54_RS05620	COG2302	S4 RNA-binding domain
HUW54_RS05625	COG3599	regulation of cell shape
HUW54_RS05635	COG2514	catechol 2,3-dioxygenase activity
HUW54_RS05650	COG0564	pseudouridine synthase activity
HUW54_RS05660	COG2233	PERMEase
HUW54_RS05705	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HUW54_RS05720	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HUW54_RS05735	COG2314	TM2 domain
HUW54_RS05750	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HUW54_RS05750	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HUW54_RS05760	COG0631	protein serine/threonine phosphatase activity
HUW54_RS05775	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HUW54_RS05790	COG1302	Protein conserved in bacteria
HUW54_RS05835	COG1196	nuclear chromosome segregation
HUW54_RS05840	COG0552	protein localization to endoplasmic reticulum
HUW54_RS05850	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HUW54_RS05880	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HUW54_RS05910	COG0758	DNA mediated transformation
HUW54_RS06005	COG0195	Participates in both transcription termination and antitermination
HUW54_RS06010	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HUW54_RS06035	COG0196	riboflavin kinase activity
HUW54_RS06060	COG2188	Transcriptional regulator
HUW54_RS06065	COG0612	Peptidase, M16
HUW54_RS06070	COG0612	Peptidase, M16
HUW54_RS06075	COG0300	oxidoreductase activity
HUW54_RS06095	COG1546	Belongs to the CinA family
HUW54_RS06095	COG1058	Belongs to the CinA family
HUW54_RS06115	COG1692	metallophosphoesterase
HUW54_RS06120	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HUW54_RS06120	COG0674	pyruvate-flavodoxin oxidoreductase activity
HUW54_RS06125	COG1013	pyruvate-flavodoxin oxidoreductase activity
HUW54_RS06160	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HUW54_RS06165	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HUW54_RS06190	COG1923	regulation of RNA biosynthetic process
HUW54_RS06205	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HUW54_RS06210	COG0789	Transcriptional regulator
HUW54_RS06310	COG1525	nuclease
HUW54_RS06325	COG0527	aspartate kinase activity
HUW54_RS06330	COG0460	homoserine dehydrogenase
HUW54_RS06335	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HUW54_RS06360	COG0833	amino acid
HUW54_RS06385	COG2340	Cysteine-rich secretory protein family
HUW54_RS06420	COG4846	Membrane protein involved in cytochrome C biogenesis
HUW54_RS06440	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HUW54_RS06450	COG0824	Thioesterase
HUW54_RS06470	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HUW54_RS06475	COG1115	amino acid carrier protein
HUW54_RS06490	COG0628	permease
HUW54_RS06515	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUW54_RS06525	COG1363	Peptidase, m42
HUW54_RS06530	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HUW54_RS06535	COG0512	Glutamine amidotransferase of anthranilate synthase
HUW54_RS06580	COG0561	phosphatase activity
HUW54_RS06625	COG0704	Plays a role in the regulation of phosphate uptake
HUW54_RS06635	COG0581	inorganic phosphate transmembrane transporter activity
HUW54_RS06640	COG0573	inorganic phosphate transmembrane transporter activity
HUW54_RS06660	COG0488	(ABC) transporter
HUW54_RS06665	COG0527	aspartate kinase activity
HUW54_RS06670	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HUW54_RS06740	COG4548	von Willebrand factor, type A
HUW54_RS06745	COG0714	Associated with various cellular activities
HUW54_RS06790	COG0671	phosphoesterase, PA-phosphatase related
HUW54_RS06870	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HUW54_RS06895	COG0531	amino acid
HUW54_RS06910	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUW54_RS06915	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HUW54_RS06930	COG0116	Belongs to the methyltransferase superfamily
HUW54_RS06965	COG4499	WXG100 protein secretion system (Wss), protein YukC
HUW54_RS06965	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUW54_RS06975	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HUW54_RS06980	COG3935	DnaD domain protein
HUW54_RS07005	COG0438	transferase activity, transferring glycosyl groups
HUW54_RS07010	COG1694	Mazg nucleotide pyrophosphohydrolase
HUW54_RS07015	COG2738	Putative neutral zinc metallopeptidase
HUW54_RS07020	COG4347	Protein of unknown function (DUF1405)
HUW54_RS07060	COG0142	geranyltranstransferase activity
HUW54_RS07105	COG0492	ferredoxin-NADP+ reductase activity
HUW54_RS07120	COG0514	ATP-dependent DNA helicase (RecQ)
HUW54_RS07130	COG1141	Ferredoxin
HUW54_RS07180	COG1388	LysM domain
HUW54_RS07180	COG0860	N-Acetylmuramoyl-L-alanine amidase
HUW54_RS07230	COG5412	phage tail tape measure protein
HUW54_RS07230	COG3953	SLT domain
HUW54_RS07500	COG5002	protein histidine kinase activity
HUW54_RS07505	COG0745	RESPONSE REGULATOR receiver
HUW54_RS07510	COG1187	pseudouridine synthase activity
HUW54_RS07535	COG0735	belongs to the Fur family
HUW54_RS07540	COG0494	nUDIX hydrolase
HUW54_RS07545	COG0667	Aldo Keto reductase
HUW54_RS07555	COG4221	oxidoreductase activity
HUW54_RS07570	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HUW54_RS07580	COG0366	Alpha amylase catalytic
HUW54_RS07585	COG1609	Transcriptional regulator
HUW54_RS07605	COG2195	Cleaves the N-terminal amino acid of tripeptides
HUW54_RS07615	COG4129	membrane
HUW54_RS07625	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUW54_RS07630	COG0022	dehydrogenase e1 component
HUW54_RS07635	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HUW54_RS07640	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUW54_RS07645	COG0497	DNA recombination
HUW54_RS07675	COG1302	Protein conserved in bacteria
HUW54_RS07680	COG0439	Biotin carboxylase
HUW54_RS07685	COG0511	ligase activity, forming carbon-carbon bonds
HUW54_RS07695	COG0006	proline dipeptidase activity
HUW54_RS07710	COG0095	Lipoate-protein ligase
HUW54_RS07715	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HUW54_RS07760	COG4537	Required for transformation and DNA binding
HUW54_RS07765	COG1459	type II secretion system
HUW54_RS07770	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HUW54_RS07775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUW54_RS07780	COG0011	TIGRFAM Protein of
HUW54_RS07785	COG1940	carbohydrate kinase activity
HUW54_RS07790	COG4483	Protein conserved in bacteria
HUW54_RS07800	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HUW54_RS07825	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HUW54_RS07830	COG1121	(ABC) transporter
HUW54_RS07840	COG0513	Belongs to the DEAD box helicase family
HUW54_RS07850	COG2384	SAM-dependent methyltransferase
HUW54_RS07870	COG0517	IMP dehydrogenase activity
HUW54_RS07890	COG0295	cytidine deaminase activity
HUW54_RS07905	COG1702	phosphate starvation-inducible protein PhoH
HUW54_RS07920	COG1030	water channel activity
HUW54_RS07930	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUW54_RS07935	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HUW54_RS07965	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HUW54_RS07980	COG1466	dna polymerase III delta subunit
HUW54_RS07985	COG2333	competence protein COMEC
HUW54_RS07985	COG0658	competence protein
HUW54_RS07990	COG2131	deaminase
HUW54_RS08000	COG2226	methyltransferase
HUW54_RS08005	COG0799	negative regulation of ribosome biogenesis
HUW54_RS08010	COG1713	HD superfamily hydrolase involved in NAD metabolism
HUW54_RS08020	COG1534	Rna-binding protein
HUW54_RS08030	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HUW54_RS08035	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HUW54_RS08055	COG3177	Filamentation induced by cAMP protein fic
HUW54_RS08060	COG1914	H( )-stimulated, divalent metal cation uptake system
HUW54_RS08070	COG0439	Biotin carboxylase
HUW54_RS08075	COG0511	ligase activity, forming carbon-carbon bonds
HUW54_RS08080	COG1984	allophanate hydrolase subunit 2
HUW54_RS08085	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HUW54_RS08135	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUW54_RS08150	COG1104	cysteine desulfurase activity
HUW54_RS08155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUW54_RS08165	COG3237	CsbD-like
HUW54_RS08170	COG1959	2 iron, 2 sulfur cluster binding
HUW54_RS08175	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HUW54_RS08180	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HUW54_RS08225	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HUW54_RS08225	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HUW54_RS08230	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUW54_RS08230	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUW54_RS08235	COG1862	Preprotein translocase
HUW54_RS08275	COG2868	ribosomal protein
HUW54_RS08320	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HUW54_RS08325	COG0285	dihydrofolate synthase activity
HUW54_RS08335	COG2818	Glycosylase
HUW54_RS08370	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HUW54_RS08405	COG4112	unkown
HUW54_RS08425	COG0833	amino acid
HUW54_RS08440	COG1484	DNA-dependent DNA replication
HUW54_RS08470	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUW54_RS08470	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUW54_RS08480	COG5002	protein histidine kinase activity
HUW54_RS08485	COG0745	RESPONSE REGULATOR receiver
HUW54_RS08495	COG0372	Belongs to the citrate synthase family
HUW54_RS08500	COG1113	amino acid transport
HUW54_RS08525	COG0281	malic enzyme
HUW54_RS08535	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HUW54_RS08540	COG4109	DRTGG domain
HUW54_RS08580	COG0827	DNA restriction-modification system
HUW54_RS08590	COG0730	response to heat
HUW54_RS08600	COG1104	cysteine desulfurase activity
HUW54_RS08615	COG1956	GAF domain-containing protein
HUW54_RS08625	COG0584	glycerophosphoryl diester phosphodiesterase
HUW54_RS08630	COG1764	response to oxidative stress
HUW54_RS08635	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HUW54_RS08640	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUW54_RS08655	COG1263	PTS System
HUW54_RS08655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUW54_RS08660	COG0204	Acyl-transferase
HUW54_RS08665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUW54_RS08695	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HUW54_RS08700	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUW54_RS08705	COG0454	-acetyltransferase
HUW54_RS08725	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HUW54_RS08725	COG1605	Chorismate mutase
HUW54_RS08750	COG1674	ftsk spoiiie
HUW54_RS08755	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUW54_RS08765	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUW54_RS08770	COG1363	Peptidase, m42
HUW54_RS08780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUW54_RS08790	COG0510	thiamine kinase activity
HUW54_RS08810	COG1187	pseudouridine synthase activity
HUW54_RS08815	COG2244	polysaccharide biosynthetic process
HUW54_RS08820	COG2081	HI0933 family
HUW54_RS08840	COG2814	Major facilitator Superfamily
HUW54_RS08845	COG1242	4 iron, 4 sulfur cluster binding
HUW54_RS08850	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HUW54_RS08860	COG2267	carboxylic ester hydrolase activity
HUW54_RS08890	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUW54_RS08890	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUW54_RS08910	COG5632	N-Acetylmuramoyl-L-alanine amidase
HUW54_RS08910	COG4193	domain, Protein
HUW54_RS08910	COG3266	domain, Protein
HUW54_RS08940	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HUW54_RS08960	COG0656	L-ascorbic acid biosynthetic process
HUW54_RS08980	COG1506	peptidase
HUW54_RS08985	COG2816	NAD+ diphosphatase activity
HUW54_RS09125	COG1131	(ABC) transporter
HUW54_RS09255	COG1131	(ABC) transporter
HUW54_RS09260	COG0537	adenosine 5'-monophosphoramidase activity
HUW54_RS09290	COG0420	3'-5' exonuclease activity
HUW54_RS09315	COG2197	response regulator
HUW54_RS09320	COG4585	Histidine kinase
HUW54_RS09320	COG2203	Gaf domain
HUW54_RS09325	COG0564	pseudouridine synthase activity
HUW54_RS09355	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HUW54_RS09360	COG1126	abc transporter atp-binding protein
HUW54_RS09365	COG0765	amino acid transport
HUW54_RS09535	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUW54_RS09540	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HUW54_RS09550	COG4129	membrane
HUW54_RS09570	COG1194	a g-specific adenine glycosylase
HUW54_RS09575	COG1988	membrane-bound metal-dependent
HUW54_RS09585	COG1134	teichoic acid transport
HUW54_RS09585	COG1388	LysM domain
HUW54_RS09615	COG0535	radical SAM domain protein
HUW54_RS09620	COG1607	acyl-coa hydrolase
HUW54_RS09625	COG2309	aminopeptidase activity
HUW54_RS09645	COG1295	ribonuclease BN
HUW54_RS09760	COG4851	CamS sex pheromone cAM373 precursor
HUW54_RS09780	COG4496	protein, YerC YecD
HUW54_RS09815	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HUW54_RS09825	COG0077	Prephenate dehydratase
HUW54_RS09835	COG0471	metal ion transport
HUW54_RS09845	COG1335	isochorismatase
HUW54_RS09860	COG1012	belongs to the aldehyde dehydrogenase family
HUW54_RS09925	COG1725	Transcriptional regulator
HUW54_RS09980	COG5632	N-Acetylmuramoyl-L-alanine amidase
HUW54_RS09980	COG1388	LysM domain
HUW54_RS10025	COG0739	heme binding
HUW54_RS10080	COG0740	serine-type endopeptidase activity
HUW54_RS10305	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HUW54_RS10370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUW54_RS10375	COG1621	beta-fructofuranosidase activity
HUW54_RS10380	COG1609	Transcriptional regulator
HUW54_RS10385	COG0004	ammonium transporteR
HUW54_RS10390	COG0425	Belongs to the sulfur carrier protein TusA family
HUW54_RS10395	COG2391	methyltransferase activity
HUW54_RS10405	COG0488	(ABC) transporter
HUW54_RS10420	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HUW54_RS10430	COG0456	acetyltransferase
HUW54_RS10435	COG1214	PFAM Peptidase M22, glycoprotease
HUW54_RS10440	COG0802	atpase or kinase
HUW54_RS10455	COG0028	Belongs to the TPP enzyme family
HUW54_RS10525	COG2183	response to ionizing radiation
HUW54_RS10530	COG1191	sigma factor activity
HUW54_RS10540	COG1366	Belongs to the anti-sigma-factor antagonist family
HUW54_RS10545	COG2208	phosphoserine phosphatase activity
HUW54_RS10575	COG3428	Bacterial PH domain
HUW54_RS10605	COG2205	protein histidine kinase activity
HUW54_RS10610	COG0745	RESPONSE REGULATOR receiver
HUW54_RS10620	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HUW54_RS10630	COG0772	Belongs to the SEDS family
HUW54_RS10645	COG1937	Protein conserved in bacteria
HUW54_RS10655	COG1418	mRNA catabolic process
HUW54_RS10690	COG0629	single-stranded DNA binding
HUW54_RS10765	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HUW54_RS10790	COG0009	L-threonylcarbamoyladenylate synthase
HUW54_RS10795	COG2890	protein-(glutamine-N5) methyltransferase activity
HUW54_RS10815	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HUW54_RS10860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUW54_RS10905	COG0813	purine-nucleoside phosphorylase activity
HUW54_RS10910	COG0783	Belongs to the Dps family
HUW54_RS10930	COG1482	cell wall glycoprotein biosynthetic process
HUW54_RS10935	COG0702	epimerase
HUW54_RS10940	COG0640	Transcriptional regulator
HUW54_RS10965	COG0561	phosphatase activity
HUW54_RS10970	COG1119	ATPase activity
HUW54_RS10985	COG3711	transcriptional antiterminator
HUW54_RS11015	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HUW54_RS11075	COG0489	protein tyrosine kinase activity
HUW54_RS11080	COG2814	Major facilitator Superfamily
HUW54_RS11095	COG1272	protein, Hemolysin III
HUW54_RS11105	COG1988	membrane-bound metal-dependent
HUW54_RS11120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUW54_RS11125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUW54_RS11130	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HUW54_RS11140	COG3457	Alanine racemase
HUW54_RS11145	COG4264	IucA IucC family
HUW54_RS11150	COG2814	Major facilitator Superfamily
HUW54_RS11175	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HUW54_RS11185	COG2130	NADP-dependent
HUW54_RS11255	COG0656	L-ascorbic acid biosynthetic process
HUW54_RS11260	COG0789	Transcriptional regulator
HUW54_RS11270	COG5492	domain, Protein
HUW54_RS11280	COG3527	Alpha-acetolactate decarboxylase
HUW54_RS11285	COG0028	Belongs to the TPP enzyme family
HUW54_RS11360	COG0201	protein transport
HUW54_RS11475	COG2252	PERMEase
HUW54_RS11520	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUW54_RS11580	COG1763	Mo-molybdopterin cofactor biosynthetic process
HUW54_RS11600	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HUW54_RS11605	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HUW54_RS11610	COG4149	molybdate abc transporter
HUW54_RS11615	COG0725	ABC transporter, periplasmic molybdate-binding protein
HUW54_RS11630	COG1268	BioY protein
HUW54_RS11645	COG1960	acyl-CoA dehydrogenase activity
HUW54_RS11650	COG4413	Urea transporter
HUW54_RS11720	COG1757	Na H antiporter
HUW54_RS11735	COG3942	CHAP domain
HUW54_RS11800	COG1113	amino acid transport
HUW54_RS11820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUW54_RS11825	COG0385	Bile acid
HUW54_RS11835	COG1263	PTS System
HUW54_RS11835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUW54_RS11840	COG1737	Transcriptional regulator
HUW54_RS11860	COG1028	Short-chain dehydrogenase reductase Sdr
HUW54_RS11865	COG1473	amidohydrolase
HUW54_RS11880	COG0583	DNA-binding transcription factor activity
HUW54_RS11900	COG2258	MOSC domain
HUW54_RS11920	COG1668	transmembrane transport
HUW54_RS11925	COG4152	abc transporter atp-binding protein
HUW54_RS11930	COG3152	Membrane
HUW54_RS11940	COG0786	glutamate:sodium symporter activity
HUW54_RS11950	COG0598	Magnesium transport protein CorA
HUW54_RS11965	COG0657	acetylesterase activity
HUW54_RS11975	COG2814	Major facilitator Superfamily
HUW54_RS11980	COG1566	PFAM secretion protein HlyD family protein
HUW54_RS11990	COG2814	Major facilitator Superfamily
HUW54_RS12050	COG1620	l-lactate permease
HUW54_RS12070	COG0604	alcohol dehydrogenase
HUW54_RS12095	COG1511	domain protein
HUW54_RS12110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUW54_RS12110	COG1263	PTS System
HUW54_RS12125	COG3871	stress protein (general stress protein 26)
HUW54_RS12175	COG2181	nitrate reductase activity
HUW54_RS12185	COG1140	nitrate reductase beta subunit
HUW54_RS12190	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HUW54_RS12200	COG2146	nitrite reductase [NAD(P)H] activity
HUW54_RS12205	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUW54_RS12215	COG0454	-acetyltransferase
HUW54_RS12220	COG2116	formate transmembrane transporter activity
HUW54_RS12235	COG3443	Belongs to the bacterial solute-binding protein 9 family
HUW54_RS12235	COG0803	Belongs to the bacterial solute-binding protein 9 family
HUW54_RS12275	COG1126	abc transporter atp-binding protein
HUW54_RS12280	COG0765	amino acid transport
HUW54_RS12285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUW54_RS12290	COG2814	Major facilitator Superfamily
HUW54_RS12305	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HUW54_RS12345	COG0156	8-amino-7-oxononanoate synthase activity
HUW54_RS12355	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HUW54_RS12360	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HUW54_RS12370	COG1132	(ABC) transporter
HUW54_RS12390	COG1929	Belongs to the glycerate kinase type-1 family
HUW54_RS12400	COG2814	Major facilitator Superfamily
HUW54_RS12420	COG1113	amino acid transport
HUW54_RS12430	COG0531	amino acid
HUW54_RS12445	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HUW54_RS12455	COG1174	glycine betaine transport
HUW54_RS12465	COG1174	glycine betaine transport
HUW54_RS12485	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
HUW54_RS12490	COG0531	amino acid
HUW54_RS12495	COG2272	Belongs to the type-B carboxylesterase lipase family
HUW54_RS12500	COG2814	Major facilitator Superfamily
HUW54_RS12505	COG0390	transport system, permease component
HUW54_RS12510	COG4619	ABC transporter
HUW54_RS12515	COG1363	Peptidase, m42
HUW54_RS12535	COG4808	Protein conserved in bacteria
HUW54_RS12540	COG0069	glutamate synthase activity
HUW54_RS12555	COG1124	(ABC) transporter
HUW54_RS12565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUW54_RS12595	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HUW54_RS12605	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HUW54_RS12610	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUW54_RS12665	COG0494	nUDIX hydrolase
HUW54_RS12750	COG1846	Transcriptional regulator
HUW54_RS12780	COG1070	Carbohydrate kinase
HUW54_RS12785	COG1802	Transcriptional regulator
HUW54_RS12790	COG0789	Transcriptional regulator
HUW54_RS12795	COG2357	RelA SpoT domain protein
HUW54_RS12800	COG4876	unkown
HUW54_RS12810	COG2271	Major facilitator Superfamily
HUW54_RS12815	COG0586	Pfam SNARE associated Golgi protein
HUW54_RS12825	COG2814	Major facilitator Superfamily
HUW54_RS12830	COG1846	Transcriptional regulator
HUW54_RS12835	COG1131	(ABC) transporter
HUW54_RS12850	COG3949	Membrane
HUW54_RS12855	COG0400	carboxylic ester hydrolase activity
HUW54_RS12865	COG1846	Transcriptional regulator
HUW54_RS12875	COG2514	catechol 2,3-dioxygenase activity
HUW54_RS12895	COG1131	(ABC) transporter
HUW54_RS12905	COG3764	Sortase (surface protein transpeptidase)
HUW54_RS12925	COG1760	l-serine dehydratase
HUW54_RS12930	COG1760	l-serine dehydratase
HUW54_RS12945	COG0697	spore germination
HUW54_RS12950	COG0657	acetylesterase activity
HUW54_RS12970	COG0028	Belongs to the TPP enzyme family
HUW54_RS12985	COG0583	DNA-binding transcription factor activity
HUW54_RS12995	COG3942	CHAP domain
HUW54_RS13005	COG3425	synthase
HUW54_RS13015	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HUW54_RS13040	COG2409	Drug exporters of the RND superfamily
HUW54_RS13085	COG0436	Aminotransferase
HUW54_RS13115	COG3942	CHAP domain
HUW54_RS13120	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HUW54_RS13120	COG2755	lipolytic protein G-D-S-L family
HUW54_RS13220	COG3001	Fructosamine kinase
HUW54_RS13225	COG0167	dihydroorotate dehydrogenase activity
HUW54_RS13275	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HUW54_RS13280	COG3527	Alpha-acetolactate decarboxylase
HUW54_RS13290	COG0531	amino acid
HUW54_RS13320	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUW54_RS13340	COG1012	belongs to the aldehyde dehydrogenase family
HUW54_RS13350	COG1510	regulation of RNA biosynthetic process
HUW54_RS13360	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HUW54_RS13385	COG2851	Citrate transporter
HUW54_RS13395	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HUW54_RS13405	COG0386	Belongs to the glutathione peroxidase family
HUW54_RS13425	COG1136	(ABC) transporter
HUW54_RS13430	COG2205	protein histidine kinase activity
HUW54_RS13435	COG0745	RESPONSE REGULATOR receiver
HUW54_RS13445	COG1785	Belongs to the alkaline phosphatase family
HUW54_RS13455	COG1846	Transcriptional regulator
HUW54_RS13500	COG1438	arginine binding
HUW54_RS13520	COG3711	transcriptional antiterminator
HUW54_RS13520	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUW54_RS13525	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HUW54_RS13525	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUW54_RS13525	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HUW54_RS13530	COG1482	cell wall glycoprotein biosynthetic process
HUW54_RS13540	COG1705	Flagellar rod assembly protein muramidase FlgJ
HUW54_RS13540	COG3942	CHAP domain
HUW54_RS13545	COG1535	isochorismatase
HUW54_RS13545	COG3433	isochorismatase activity
HUW54_RS13560	COG0438	transferase activity, transferring glycosyl groups
HUW54_RS13575	COG1073	alpha beta
HUW54_RS13595	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HUW54_RS13615	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HUW54_RS13705	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUW54_RS13790	COG0471	metal ion transport
HUW54_RS13795	COG2962	Rard protein
HUW54_RS13805	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HUW54_RS13820	COG1136	(ABC) transporter
HUW54_RS13825	COG0577	efflux transmembrane transporter activity
HUW54_RS13835	COG1278	Cold shock
HUW54_RS13855	COG1475	DNA binding