locus-tag	class	description
HLB22_RS00015	COG2501	S4 domain
HLB22_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HLB22_RS00060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HLB22_RS00070	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HLB22_RS00080	COG0305	Participates in initiation and elongation during chromosome replication
HLB22_RS00110	COG4863	YycH protein
HLB22_RS00120	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HLB22_RS00125	COG0737	Belongs to the 5'-nucleotidase family
HLB22_RS00155	COG0584	glycerophosphoryl diester phosphodiesterase
HLB22_RS00160	COG2030	dehydratase
HLB22_RS00255	COG0583	DNA-binding transcription factor activity
HLB22_RS00270	COG0655	NAD(P)H dehydrogenase (quinone) activity
HLB22_RS00300	COG2814	Major facilitator Superfamily
HLB22_RS00320	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HLB22_RS00330	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HLB22_RS00375	COG0823	Involved in the tonB-independent uptake of proteins
HLB22_RS00395	COG1473	amidohydrolase
HLB22_RS00405	COG1283	sodium-dependent phosphate transmembrane transporter activity
HLB22_RS00410	COG4716	Myosin-crossreactive antigen
HLB22_RS00420	COG1620	l-lactate permease
HLB22_RS00435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLB22_RS00440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLB22_RS00445	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HLB22_RS00455	COG2423	ornithine cyclodeaminase activity
HLB22_RS00460	COG4264	IucA IucC family
HLB22_RS00465	COG2814	Major facilitator Superfamily
HLB22_RS00470	COG4264	IucA IucC family
HLB22_RS00475	COG4264	IucA IucC family
HLB22_RS00485	COG0019	diaminopimelate decarboxylase activity
HLB22_RS00490	COG1475	DNA binding
HLB22_RS00515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HLB22_RS00520	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HLB22_RS00525	COG0438	transferase activity, transferring glycosyl groups
HLB22_RS00550	COG0813	purine-nucleoside phosphorylase activity
HLB22_RS00555	COG2814	Major facilitator Superfamily
HLB22_RS00575	COG3639	organic phosphonate transmembrane transporter activity
HLB22_RS00595	COG0737	Belongs to the 5'-nucleotidase family
HLB22_RS00610	COG1012	belongs to the aldehyde dehydrogenase family
HLB22_RS00610	COG1454	alcohol dehydrogenase
HLB22_RS00640	COG1086	Polysaccharide biosynthesis protein
HLB22_RS00650	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HLB22_RS00680	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HLB22_RS00690	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HLB22_RS00695	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HLB22_RS00705	COG2832	Protein of unknown function (DUF454)
HLB22_RS00740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLB22_RS00750	COG5609	conserved protein (DUF2294)
HLB22_RS00800	COG1114	Component of the transport system for branched-chain amino acids
HLB22_RS00805	COG1335	isochorismatase
HLB22_RS00810	COG3961	Belongs to the TPP enzyme family
HLB22_RS00840	COG1737	Transcriptional regulator
HLB22_RS00880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLB22_RS00890	COG0405	Gamma-glutamyltransferase
HLB22_RS00910	COG3842	ATPase activity
HLB22_RS00920	COG1175	transmembrane transport
HLB22_RS00925	COG3833	ABC-type maltose transport systems, permease component
HLB22_RS00930	COG0673	inositol 2-dehydrogenase activity
HLB22_RS00935	COG0673	inositol 2-dehydrogenase activity
HLB22_RS00945	COG1755	Isoprenylcysteine carboxyl methyltransferase
HLB22_RS01000	COG0183	Belongs to the thiolase family
HLB22_RS01010	COG1960	acyl-CoA dehydrogenase activity
HLB22_RS01015	COG0318	PFAM AMP-dependent synthetase and ligase
HLB22_RS01035	COG0747	negative chemotaxis
HLB22_RS01040	COG3189	MarR family transcriptional regulator
HLB22_RS01065	COG2190	(PTS) system
HLB22_RS01065	COG1263	PTS System
HLB22_RS01065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLB22_RS01070	COG1957	nucleoside hydrolase
HLB22_RS01090	COG3414	Phosphotransferase system galactitol-specific IIB component
HLB22_RS01095	COG3775	system Galactitol-specific IIC component
HLB22_RS01100	COG1063	alcohol dehydrogenase
HLB22_RS01110	COG1063	alcohol dehydrogenase
HLB22_RS01120	COG1063	alcohol dehydrogenase
HLB22_RS01125	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HLB22_RS01130	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HLB22_RS01140	COG1063	alcohol dehydrogenase
HLB22_RS01145	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HLB22_RS01185	COG2188	Transcriptional regulator
HLB22_RS01190	COG1263	PTS System
HLB22_RS01190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLB22_RS01190	COG2190	(PTS) system
HLB22_RS01195	COG2723	6-phospho-beta-galactosidase activity
HLB22_RS01200	COG2226	methyltransferase
HLB22_RS01255	COG1131	(ABC) transporter
HLB22_RS01275	COG3942	CHAP domain
HLB22_RS01275	COG1388	LysM domain
HLB22_RS01385	COG1114	Component of the transport system for branched-chain amino acids
HLB22_RS01390	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HLB22_RS01395	COG0577	efflux transmembrane transporter activity
HLB22_RS01420	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HLB22_RS01425	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HLB22_RS01475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HLB22_RS01505	COG3037	sugar-specific permease SgaT UlaA
HLB22_RS01515	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLB22_RS01520	COG3711	transcriptional antiterminator
HLB22_RS01540	COG2271	Major facilitator Superfamily
HLB22_RS01545	COG0346	lactoylglutathione lyase activity
HLB22_RS01550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HLB22_RS01555	COG0431	NADPH-dependent FMN reductase
HLB22_RS01565	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLB22_RS01570	COG2822	iron ion transport
HLB22_RS01580	COG0672	)-iron permease
HLB22_RS01585	COG0805	protein transport
HLB22_RS01590	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HLB22_RS01600	COG1476	TRANSCRIPTIONal
HLB22_RS01610	COG1131	(ABC) transporter
HLB22_RS01640	COG0646	methionine synthase
HLB22_RS01640	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HLB22_RS01645	COG0626	cystathionine gamma-synthase activity
HLB22_RS01650	COG0626	cystathionine gamma-synthase activity
HLB22_RS01655	COG1475	DNA binding
HLB22_RS01660	COG0668	transmembrane transport
HLB22_RS01665	COG4481	Protein conserved in bacteria
HLB22_RS01670	COG0012	GTP binding
HLB22_RS01770	COG1823	symporter activity
HLB22_RS01800	COG2233	PERMEase
HLB22_RS01845	COG3759	membrane
HLB22_RS01960	COG0523	cobalamin synthesis protein
HLB22_RS01985	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HLB22_RS01995	COG5609	conserved protein (DUF2294)
HLB22_RS02010	COG1647	Serine aminopeptidase, S33
HLB22_RS02020	COG0733	neurotransmitter:sodium symporter activity
HLB22_RS02025	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HLB22_RS02030	COG0626	cystathionine gamma-synthase activity
HLB22_RS02040	COG2011	ABC-type metal ion transport system permease component
HLB22_RS02045	COG1464	Belongs to the NlpA lipoprotein family
HLB22_RS02060	COG0494	nUDIX hydrolase
HLB22_RS02080	COG0583	DNA-binding transcription factor activity
HLB22_RS02085	COG0067	glutamate synthase
HLB22_RS02085	COG0069	glutamate synthase activity
HLB22_RS02085	COG0070	glutamate synthase
HLB22_RS02090	COG0493	'glutamate synthase
HLB22_RS02100	COG1263	PTS System
HLB22_RS02100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLB22_RS02105	COG0366	Alpha amylase catalytic
HLB22_RS02110	COG2188	Transcriptional regulator
HLB22_RS02130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HLB22_RS02165	COG1982	Orn Lys Arg decarboxylase major
HLB22_RS02175	COG3870	Protein conserved in bacteria
HLB22_RS02180	COG0470	DNA polymerase III
HLB22_RS02185	COG1774	PSP1 C-terminal conserved region
HLB22_RS02195	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HLB22_RS02205	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HLB22_RS02215	COG0084	hydrolase, TatD family'
HLB22_RS02220	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HLB22_RS02230	COG4466	Protein conserved in bacteria
HLB22_RS02240	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HLB22_RS02245	COG0251	oxidation-reduction process
HLB22_RS02285	COG2244	polysaccharide biosynthetic process
HLB22_RS02290	COG3956	TIGRFAM MazG family protein
HLB22_RS02295	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HLB22_RS02305	COG1098	S1 RNA binding domain
HLB22_RS02320	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HLB22_RS02345	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HLB22_RS02440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLB22_RS02455	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HLB22_RS02465	COG3880	PFAM UvrB UvrC protein
HLB22_RS02480	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HLB22_RS02485	COG4956	integral membrane protein (PIN domain superfamily)
HLB22_RS02505	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HLB22_RS02560	COG2813	Specifically methylates the guanine in position
HLB22_RS02600	COG1473	amidohydrolase
HLB22_RS02630	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HLB22_RS02635	COG1428	Deoxynucleoside kinase
HLB22_RS02640	COG1428	Deoxynucleoside kinase
HLB22_RS02650	COG0561	phosphatase activity
HLB22_RS02690	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HLB22_RS02795	COG0095	Lipoate-protein ligase
HLB22_RS02800	COG0083	homoserine kinase activity
HLB22_RS02820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HLB22_RS02855	COG0667	Aldo Keto reductase
HLB22_RS02860	COG0655	NAD(P)H dehydrogenase (quinone) activity
HLB22_RS02870	COG1078	dGTPase activity
HLB22_RS02905	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HLB22_RS02910	COG4139	cobalamin transport
HLB22_RS03010	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HLB22_RS03015	COG1121	(ABC) transporter
HLB22_RS03020	COG1321	iron dependent repressor
HLB22_RS03030	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HLB22_RS03040	COG1682	transport, permease protein
HLB22_RS03045	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HLB22_RS03055	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HLB22_RS03060	COG1686	Belongs to the peptidase S11 family
HLB22_RS03065	COG1132	(ABC) transporter
HLB22_RS03070	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HLB22_RS03080	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLB22_RS03085	COG1120	ATPase activity
HLB22_RS03090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLB22_RS03095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLB22_RS03100	COG2376	Dihydroxyacetone kinase
HLB22_RS03120	COG3949	Membrane
HLB22_RS03140	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HLB22_RS03155	COG1136	(ABC) transporter
HLB22_RS03160	COG0577	efflux transmembrane transporter activity
HLB22_RS03165	COG1392	Phosphate transport regulator
HLB22_RS03170	COG0306	phosphate transporter
HLB22_RS03175	COG1388	LysM domain
HLB22_RS03175	COG3942	CHAP domain
HLB22_RS03185	COG4977	sequence-specific DNA binding
HLB22_RS03185	COG1917	Cupin 2, conserved barrel domain protein
HLB22_RS03215	COG0583	DNA-binding transcription factor activity
HLB22_RS03225	COG2814	Major facilitator Superfamily
HLB22_RS03230	COG2839	Protein conserved in bacteria
HLB22_RS03260	COG1611	Belongs to the LOG family
HLB22_RS03280	COG4988	ABC transporter
HLB22_RS03285	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HLB22_RS03295	COG0523	cobalamin synthesis protein
HLB22_RS03300	COG4989	oxidoreductase activity
HLB22_RS03310	COG0471	metal ion transport
HLB22_RS03345	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HLB22_RS03350	COG1349	DNA-binding transcription factor activity
HLB22_RS03355	COG1105	Belongs to the carbohydrate kinase PfkB family
HLB22_RS03360	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLB22_RS03360	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLB22_RS03360	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLB22_RS03365	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HLB22_RS03370	COG1253	flavin adenine dinucleotide binding
HLB22_RS03375	COG0656	L-ascorbic acid biosynthetic process
HLB22_RS03380	COG0463	Glycosyl transferase, family 2
HLB22_RS03415	COG0720	synthase
HLB22_RS03425	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HLB22_RS03425	COG0512	Glutamine amidotransferase of anthranilate synthase
HLB22_RS03430	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HLB22_RS03460	COG0488	(ABC) transporter
HLB22_RS03465	COG0514	ATP-dependent DNA helicase (RecQ)
HLB22_RS03470	COG1125	glycine betaine transport
HLB22_RS03470	COG0517	IMP dehydrogenase activity
HLB22_RS03475	COG1174	glycine betaine transport
HLB22_RS03500	COG3104	oligopeptide transport
HLB22_RS03520	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HLB22_RS03525	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HLB22_RS03530	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLB22_RS03535	COG4605	iron ion homeostasis
HLB22_RS03540	COG4604	ABC transporter, ATP-binding protein
HLB22_RS03545	COG4607	ABC-type enterochelin transport system periplasmic component
HLB22_RS03600	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HLB22_RS03605	COG1739	Uncharacterized protein family UPF0029
HLB22_RS03615	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HLB22_RS03620	COG1040	competence protein
HLB22_RS03650	COG1388	LysM domain
HLB22_RS03650	COG3942	CHAP domain
HLB22_RS03705	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HLB22_RS03720	COG0281	malic enzyme
HLB22_RS03770	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HLB22_RS03775	COG1647	Serine aminopeptidase, S33
HLB22_RS03780	COG0557	exoribonuclease II activity
HLB22_RS03840	COG1278	Cold shock
HLB22_RS03880	COG0406	alpha-ribazole phosphatase activity
HLB22_RS03885	COG1279	arginine transmembrane transporter activity
HLB22_RS03910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HLB22_RS03915	COG1393	Belongs to the ArsC family
HLB22_RS03925	COG3878	Protein conserved in bacteria
HLB22_RS03930	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HLB22_RS03945	COG2011	ABC-type metal ion transport system permease component
HLB22_RS03950	COG1464	Belongs to the NlpA lipoprotein family
HLB22_RS03965	COG0396	ATPase activity
HLB22_RS03970	COG0719	Fe-S assembly protein
HLB22_RS03980	COG0822	iron-sulfur transferase activity
HLB22_RS04000	COG1253	flavin adenine dinucleotide binding
HLB22_RS04015	COG1801	Protein of unknown function DUF72
HLB22_RS04020	COG0730	response to heat
HLB22_RS04035	COG4470	Protein conserved in bacteria
HLB22_RS04045	COG2445	Protein of unknown function DUF86
HLB22_RS04075	COG1696	Membrane protein involved in D-alanine export
HLB22_RS04085	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HLB22_RS04090	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HLB22_RS04095	COG4837	Protein of unknown function (DUF1462)
HLB22_RS04100	COG1252	NADH dehydrogenase
HLB22_RS04110	COG0316	Belongs to the HesB IscA family
HLB22_RS04120	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HLB22_RS04125	COG2056	Na+-H+ antiporter family
HLB22_RS04130	COG2050	protein possibly involved in aromatic compounds catabolism
HLB22_RS04185	COG1098	S1 RNA binding domain
HLB22_RS04190	COG1902	pentaerythritol trinitrate reductase activity
HLB22_RS04205	COG0584	glycerophosphoryl diester phosphodiesterase
HLB22_RS04225	COG0398	Pfam SNARE associated Golgi protein
HLB22_RS04265	COG0561	phosphatase activity
HLB22_RS04290	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HLB22_RS04305	COG1881	PFAM PEBP family protein
HLB22_RS04335	COG0601	transmembrane transport
HLB22_RS04340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLB22_RS04345	COG0444	Belongs to the ABC transporter superfamily
HLB22_RS04350	COG4608	Belongs to the ABC transporter superfamily
HLB22_RS04355	COG4166	transmembrane transport
HLB22_RS04360	COG0747	negative chemotaxis
HLB22_RS04365	COG0444	Belongs to the ABC transporter superfamily
HLB22_RS04370	COG4608	Belongs to the ABC transporter superfamily
HLB22_RS04375	COG0601	transmembrane transport
HLB22_RS04380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLB22_RS04415	COG1164	Oligoendopeptidase f
HLB22_RS04425	COG2346	COG2346, Truncated hemoglobins
HLB22_RS04440	COG2357	RelA SpoT domain protein
HLB22_RS04450	COG0564	pseudouridine synthase activity
HLB22_RS04455	COG2239	Acts as a magnesium transporter
HLB22_RS04460	COG0569	domain protein
HLB22_RS04460	COG0475	glutathione-regulated potassium exporter activity
HLB22_RS04470	COG0628	permease
HLB22_RS04475	COG1115	amino acid carrier protein
HLB22_RS04515	COG0861	Integral membrane protein TerC family
HLB22_RS04525	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HLB22_RS04530	COG0737	Belongs to the 5'-nucleotidase family
HLB22_RS04545	COG4903	ComK protein
HLB22_RS04560	COG4873	Protein conserved in bacteria
HLB22_RS04635	COG2314	TM2 domain
HLB22_RS04645	COG1575	Belongs to the MenA family. Type 1 subfamily
HLB22_RS04650	COG1169	isochorismate synthase
HLB22_RS04660	COG2267	carboxylic ester hydrolase activity
HLB22_RS04685	COG0436	Aminotransferase
HLB22_RS04690	COG3594	Acyltransferase
HLB22_RS04720	COG1316	TRANSCRIPTIONal
HLB22_RS04760	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HLB22_RS04775	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HLB22_RS04815	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HLB22_RS04820	COG4172	Belongs to the ABC transporter superfamily
HLB22_RS04825	COG4721	ABC-type cobalt transport system, permease component
HLB22_RS04840	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HLB22_RS04860	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HLB22_RS04865	COG1271	oxidase subunit
HLB22_RS04870	COG1294	oxidase, subunit
HLB22_RS04875	COG0569	domain protein
HLB22_RS04940	COG1176	ABC-type spermidine putrescine transport system, permease component I
HLB22_RS04945	COG1177	transmembrane transport
HLB22_RS04950	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HLB22_RS04975	COG0483	inositol monophosphate 1-phosphatase activity
HLB22_RS04995	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HLB22_RS05005	COG0772	Belongs to the SEDS family
HLB22_RS05035	COG3679	Belongs to the UPF0342 family
HLB22_RS05055	COG0742	ribosomal rna small subunit methyltransferase
HLB22_RS05110	COG4509	Sortase family
HLB22_RS05125	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HLB22_RS05155	COG1796	DNA polymerase
HLB22_RS05155	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HLB22_RS05180	COG2009	succinate dehydrogenase
HLB22_RS05185	COG1053	succinate dehydrogenase
HLB22_RS05190	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HLB22_RS05310	COG1288	antiporter activity
HLB22_RS05345	COG1011	Hydrolase
HLB22_RS05370	COG4839	cell division protein FtsL
HLB22_RS05390	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HLB22_RS05395	COG0849	cell division
HLB22_RS05410	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HLB22_RS05420	COG0762	integral membrane protein
HLB22_RS05425	COG2302	S4 RNA-binding domain
HLB22_RS05430	COG3599	regulation of cell shape
HLB22_RS05440	COG2514	catechol 2,3-dioxygenase activity
HLB22_RS05455	COG0564	pseudouridine synthase activity
HLB22_RS05465	COG2233	PERMEase
HLB22_RS05510	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HLB22_RS05525	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HLB22_RS05530	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HLB22_RS05555	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HLB22_RS05555	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HLB22_RS05565	COG0631	protein serine/threonine phosphatase activity
HLB22_RS05580	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HLB22_RS05595	COG1302	Protein conserved in bacteria
HLB22_RS05640	COG1196	nuclear chromosome segregation
HLB22_RS05645	COG0552	protein localization to endoplasmic reticulum
HLB22_RS05655	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HLB22_RS05715	COG0758	DNA mediated transformation
HLB22_RS05810	COG0195	Participates in both transcription termination and antitermination
HLB22_RS05815	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HLB22_RS05840	COG0196	riboflavin kinase activity
HLB22_RS05865	COG2188	Transcriptional regulator
HLB22_RS05870	COG0612	Peptidase, M16
HLB22_RS05875	COG0612	Peptidase, M16
HLB22_RS05880	COG0300	oxidoreductase activity
HLB22_RS05900	COG1546	Belongs to the CinA family
HLB22_RS05900	COG1058	Belongs to the CinA family
HLB22_RS05925	COG1692	metallophosphoesterase
HLB22_RS05930	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HLB22_RS05930	COG0674	pyruvate-flavodoxin oxidoreductase activity
HLB22_RS05935	COG1013	pyruvate-flavodoxin oxidoreductase activity
HLB22_RS05970	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HLB22_RS05975	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HLB22_RS06000	COG1923	regulation of RNA biosynthetic process
HLB22_RS06015	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HLB22_RS06020	COG0789	Transcriptional regulator
HLB22_RS06090	COG3344	reverse transcriptase
HLB22_RS06150	COG1131	(ABC) transporter
HLB22_RS06165	COG2197	response regulator
HLB22_RS06175	COG1525	nuclease
HLB22_RS06190	COG0527	aspartate kinase activity
HLB22_RS06195	COG0460	homoserine dehydrogenase
HLB22_RS06200	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HLB22_RS06225	COG0833	amino acid
HLB22_RS06250	COG2340	Cysteine-rich secretory protein family
HLB22_RS06285	COG4846	Membrane protein involved in cytochrome C biogenesis
HLB22_RS06305	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HLB22_RS06320	COG0824	Thioesterase
HLB22_RS06345	COG1115	amino acid carrier protein
HLB22_RS06360	COG0628	permease
HLB22_RS06385	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HLB22_RS06395	COG1363	Peptidase, m42
HLB22_RS06400	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HLB22_RS06405	COG0512	Glutamine amidotransferase of anthranilate synthase
HLB22_RS06465	COG2946	Replication initiation factor
HLB22_RS06485	COG0433	COG0433 Predicted ATPase
HLB22_RS06500	COG1674	ftsk spoiiie
HLB22_RS06530	COG2826	transposase and inactivated derivatives, IS30 family
HLB22_RS06540	COG0561	phosphatase activity
HLB22_RS06585	COG0704	Plays a role in the regulation of phosphate uptake
HLB22_RS06595	COG0581	inorganic phosphate transmembrane transporter activity
HLB22_RS06600	COG0573	inorganic phosphate transmembrane transporter activity
HLB22_RS06615	COG0488	(ABC) transporter
HLB22_RS06620	COG0527	aspartate kinase activity
HLB22_RS06625	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HLB22_RS06695	COG4548	von Willebrand factor, type A
HLB22_RS06700	COG0714	Associated with various cellular activities
HLB22_RS06745	COG0671	phosphoesterase, PA-phosphatase related
HLB22_RS06820	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HLB22_RS06840	COG0531	amino acid
HLB22_RS06855	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HLB22_RS06860	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HLB22_RS06875	COG0116	Belongs to the methyltransferase superfamily
HLB22_RS06905	COG4499	WXG100 protein secretion system (Wss), protein YukC
HLB22_RS06905	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HLB22_RS06915	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HLB22_RS06920	COG3935	DnaD domain protein
HLB22_RS06945	COG0438	transferase activity, transferring glycosyl groups
HLB22_RS06950	COG1694	Mazg nucleotide pyrophosphohydrolase
HLB22_RS06955	COG2738	Putative neutral zinc metallopeptidase
HLB22_RS06960	COG4347	Protein of unknown function (DUF1405)
HLB22_RS07000	COG0142	geranyltranstransferase activity
HLB22_RS07055	COG0492	ferredoxin-NADP+ reductase activity
HLB22_RS07070	COG0514	ATP-dependent DNA helicase (RecQ)
HLB22_RS07080	COG1141	Ferredoxin
HLB22_RS07125	COG5632	N-Acetylmuramoyl-L-alanine amidase
HLB22_RS07125	COG1388	LysM domain
HLB22_RS07185	COG5280	Phage tail tape measure protein TP901
HLB22_RS07185	COG3953	SLT domain
HLB22_RS07445	COG0582	viral genome integration into host DNA
HLB22_RS07475	COG5002	protein histidine kinase activity
HLB22_RS07480	COG0745	RESPONSE REGULATOR receiver
HLB22_RS07485	COG1187	pseudouridine synthase activity
HLB22_RS07510	COG0735	belongs to the Fur family
HLB22_RS07515	COG0494	nUDIX hydrolase
HLB22_RS07520	COG0667	Aldo Keto reductase
HLB22_RS07530	COG4221	oxidoreductase activity
HLB22_RS07545	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HLB22_RS07555	COG0366	Alpha amylase catalytic
HLB22_RS07560	COG1609	Transcriptional regulator
HLB22_RS07580	COG2195	Cleaves the N-terminal amino acid of tripeptides
HLB22_RS07590	COG4129	membrane
HLB22_RS07600	COG0508	dehydrogenase complex catalyzes the overall conversion of
HLB22_RS07605	COG0022	dehydrogenase e1 component
HLB22_RS07610	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HLB22_RS07615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HLB22_RS07620	COG0497	DNA recombination
HLB22_RS07650	COG1302	Protein conserved in bacteria
HLB22_RS07655	COG0439	Biotin carboxylase
HLB22_RS07660	COG0511	ligase activity, forming carbon-carbon bonds
HLB22_RS07670	COG0006	proline dipeptidase activity
HLB22_RS07685	COG0095	Lipoate-protein ligase
HLB22_RS07690	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HLB22_RS07735	COG4537	Required for transformation and DNA binding
HLB22_RS07740	COG1459	type II secretion system
HLB22_RS07745	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HLB22_RS07750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLB22_RS07755	COG0011	TIGRFAM Protein of
HLB22_RS07760	COG1940	carbohydrate kinase activity
HLB22_RS07765	COG4483	Protein conserved in bacteria
HLB22_RS07775	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HLB22_RS07800	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HLB22_RS07805	COG1121	(ABC) transporter
HLB22_RS07815	COG0513	Belongs to the DEAD box helicase family
HLB22_RS07825	COG2384	SAM-dependent methyltransferase
HLB22_RS07845	COG0517	IMP dehydrogenase activity
HLB22_RS07865	COG0295	cytidine deaminase activity
HLB22_RS07880	COG1702	phosphate starvation-inducible protein PhoH
HLB22_RS07895	COG1030	water channel activity
HLB22_RS07905	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HLB22_RS07910	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HLB22_RS07940	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HLB22_RS07955	COG1466	dna polymerase III delta subunit
HLB22_RS07960	COG2333	competence protein COMEC
HLB22_RS07960	COG0658	competence protein
HLB22_RS07965	COG2131	deaminase
HLB22_RS07970	COG2183	response to ionizing radiation
HLB22_RS07975	COG2226	methyltransferase
HLB22_RS07980	COG0799	negative regulation of ribosome biogenesis
HLB22_RS07985	COG1713	HD superfamily hydrolase involved in NAD metabolism
HLB22_RS07995	COG1534	Rna-binding protein
HLB22_RS08005	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HLB22_RS08010	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HLB22_RS08030	COG3177	Filamentation induced by cAMP protein fic
HLB22_RS08035	COG1914	H( )-stimulated, divalent metal cation uptake system
HLB22_RS08045	COG0439	Biotin carboxylase
HLB22_RS08050	COG0511	ligase activity, forming carbon-carbon bonds
HLB22_RS08055	COG1984	allophanate hydrolase subunit 2
HLB22_RS08060	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HLB22_RS08110	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HLB22_RS08125	COG1104	cysteine desulfurase activity
HLB22_RS08130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HLB22_RS08140	COG3237	CsbD-like
HLB22_RS08145	COG1959	2 iron, 2 sulfur cluster binding
HLB22_RS08150	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HLB22_RS08155	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HLB22_RS08200	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HLB22_RS08200	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HLB22_RS08205	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HLB22_RS08205	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HLB22_RS08210	COG1862	Preprotein translocase
HLB22_RS08250	COG2868	ribosomal protein
HLB22_RS08295	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HLB22_RS08300	COG0285	dihydrofolate synthase activity
HLB22_RS08310	COG2818	Glycosylase
HLB22_RS08345	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HLB22_RS08380	COG4112	unkown
HLB22_RS08400	COG0833	amino acid
HLB22_RS08415	COG1484	DNA-dependent DNA replication
HLB22_RS08445	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HLB22_RS08445	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HLB22_RS08455	COG5002	protein histidine kinase activity
HLB22_RS08460	COG0745	RESPONSE REGULATOR receiver
HLB22_RS08470	COG0372	Belongs to the citrate synthase family
HLB22_RS08475	COG1113	amino acid transport
HLB22_RS08500	COG0281	malic enzyme
HLB22_RS08510	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HLB22_RS08515	COG4109	DRTGG domain
HLB22_RS08555	COG0827	DNA restriction-modification system
HLB22_RS08565	COG0730	response to heat
HLB22_RS08575	COG1104	cysteine desulfurase activity
HLB22_RS08590	COG1956	GAF domain-containing protein
HLB22_RS08600	COG0584	glycerophosphoryl diester phosphodiesterase
HLB22_RS08605	COG1764	response to oxidative stress
HLB22_RS08610	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HLB22_RS08615	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HLB22_RS08630	COG1263	PTS System
HLB22_RS08630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLB22_RS08635	COG0204	Acyl-transferase
HLB22_RS08640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HLB22_RS08660	COG5386	Cell surface protein
HLB22_RS08675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HLB22_RS08680	COG0454	-acetyltransferase
HLB22_RS08700	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HLB22_RS08700	COG1605	Chorismate mutase
HLB22_RS08725	COG1674	ftsk spoiiie
HLB22_RS08730	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HLB22_RS08740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HLB22_RS08745	COG1363	Peptidase, m42
HLB22_RS08755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLB22_RS08765	COG0510	thiamine kinase activity
HLB22_RS08785	COG1187	pseudouridine synthase activity
HLB22_RS08790	COG2244	polysaccharide biosynthetic process
HLB22_RS08795	COG2081	HI0933 family
HLB22_RS08815	COG2814	Major facilitator Superfamily
HLB22_RS08820	COG1242	4 iron, 4 sulfur cluster binding
HLB22_RS08825	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HLB22_RS08840	COG2267	carboxylic ester hydrolase activity
HLB22_RS08870	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HLB22_RS08870	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HLB22_RS08905	COG4193	domain, Protein
HLB22_RS08905	COG5632	N-Acetylmuramoyl-L-alanine amidase
HLB22_RS08905	COG3266	domain, Protein
HLB22_RS08940	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HLB22_RS08965	COG0656	L-ascorbic acid biosynthetic process
HLB22_RS08985	COG1506	peptidase
HLB22_RS09110	COG0758	DNA mediated transformation
HLB22_RS09235	COG1131	(ABC) transporter
HLB22_RS09240	COG0537	adenosine 5'-monophosphoramidase activity
HLB22_RS09270	COG0420	3'-5' exonuclease activity
HLB22_RS09290	COG2197	response regulator
HLB22_RS09295	COG4585	Histidine kinase
HLB22_RS09295	COG2203	Gaf domain
HLB22_RS09300	COG0564	pseudouridine synthase activity
HLB22_RS09330	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HLB22_RS09335	COG1126	abc transporter atp-binding protein
HLB22_RS09340	COG0765	amino acid transport
HLB22_RS09525	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HLB22_RS09530	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HLB22_RS09540	COG4129	membrane
HLB22_RS09565	COG1988	membrane-bound metal-dependent
HLB22_RS09575	COG1134	teichoic acid transport
HLB22_RS09575	COG1388	LysM domain
HLB22_RS09605	COG0535	radical SAM domain protein
HLB22_RS09610	COG1607	acyl-coa hydrolase
HLB22_RS09615	COG2309	aminopeptidase activity
HLB22_RS09635	COG1295	ribonuclease BN
HLB22_RS09750	COG4851	CamS sex pheromone cAM373 precursor
HLB22_RS09770	COG4496	protein, YerC YecD
HLB22_RS09810	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HLB22_RS09820	COG0077	Prephenate dehydratase
HLB22_RS09830	COG0471	metal ion transport
HLB22_RS09840	COG1335	isochorismatase
HLB22_RS09855	COG1012	belongs to the aldehyde dehydrogenase family
HLB22_RS09865	COG3682	Transcriptional regulator
HLB22_RS09890	COG4974	Belongs to the 'phage' integrase family
HLB22_RS09940	COG1131	(ABC) transporter
HLB22_RS09955	COG1725	Transcriptional regulator
HLB22_RS10015	COG1388	LysM domain
HLB22_RS10015	COG5632	N-Acetylmuramoyl-L-alanine amidase
HLB22_RS10060	COG0739	heme binding
HLB22_RS10110	COG0740	serine-type endopeptidase activity
HLB22_RS10330	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HLB22_RS10335	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HLB22_RS10340	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HLB22_RS10355	COG3728	DNA packaging
HLB22_RS10355	COG5484	DNA packaging
HLB22_RS10430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLB22_RS10435	COG1621	beta-fructofuranosidase activity
HLB22_RS10440	COG1609	Transcriptional regulator
HLB22_RS10445	COG0004	ammonium transporteR
HLB22_RS10450	COG0425	Belongs to the sulfur carrier protein TusA family
HLB22_RS10455	COG2391	methyltransferase activity
HLB22_RS10465	COG0488	(ABC) transporter
HLB22_RS10480	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HLB22_RS10490	COG0456	acetyltransferase
HLB22_RS10495	COG1214	PFAM Peptidase M22, glycoprotease
HLB22_RS10500	COG0802	atpase or kinase
HLB22_RS10515	COG0028	Belongs to the TPP enzyme family
HLB22_RS10595	COG2183	response to ionizing radiation
HLB22_RS10600	COG1191	sigma factor activity
HLB22_RS10610	COG1366	Belongs to the anti-sigma-factor antagonist family
HLB22_RS10615	COG2208	phosphoserine phosphatase activity
HLB22_RS10645	COG3428	Bacterial PH domain
HLB22_RS10675	COG2205	protein histidine kinase activity
HLB22_RS10680	COG0745	RESPONSE REGULATOR receiver
HLB22_RS10690	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HLB22_RS10700	COG0772	Belongs to the SEDS family
HLB22_RS10715	COG1937	Protein conserved in bacteria
HLB22_RS10725	COG1418	mRNA catabolic process
HLB22_RS10760	COG0629	single-stranded DNA binding
HLB22_RS10835	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HLB22_RS10860	COG0009	L-threonylcarbamoyladenylate synthase
HLB22_RS10865	COG2890	protein-(glutamine-N5) methyltransferase activity
HLB22_RS10885	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HLB22_RS10925	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLB22_RS10970	COG0813	purine-nucleoside phosphorylase activity
HLB22_RS10975	COG0783	Belongs to the Dps family
HLB22_RS10995	COG1482	cell wall glycoprotein biosynthetic process
HLB22_RS11000	COG0702	epimerase
HLB22_RS11005	COG0640	Transcriptional regulator
HLB22_RS11035	COG0561	phosphatase activity
HLB22_RS11040	COG1119	ATPase activity
HLB22_RS11055	COG3711	transcriptional antiterminator
HLB22_RS11085	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HLB22_RS11145	COG0489	protein tyrosine kinase activity
HLB22_RS11150	COG2814	Major facilitator Superfamily
HLB22_RS11165	COG1272	protein, Hemolysin III
HLB22_RS11175	COG1988	membrane-bound metal-dependent
HLB22_RS11190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLB22_RS11195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLB22_RS11200	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HLB22_RS11210	COG3457	Alanine racemase
HLB22_RS11215	COG4264	IucA IucC family
HLB22_RS11220	COG2814	Major facilitator Superfamily
HLB22_RS11245	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HLB22_RS11255	COG2130	NADP-dependent
HLB22_RS11325	COG0656	L-ascorbic acid biosynthetic process
HLB22_RS11330	COG0789	Transcriptional regulator
HLB22_RS11340	COG5492	domain, Protein
HLB22_RS11355	COG0438	transferase activity, transferring glycosyl groups
HLB22_RS11370	COG3527	Alpha-acetolactate decarboxylase
HLB22_RS11375	COG0028	Belongs to the TPP enzyme family
HLB22_RS11460	COG0201	protein transport
HLB22_RS11575	COG2252	PERMEase
HLB22_RS11620	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HLB22_RS11680	COG1763	Mo-molybdopterin cofactor biosynthetic process
HLB22_RS11700	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HLB22_RS11705	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HLB22_RS11710	COG4149	molybdate abc transporter
HLB22_RS11715	COG0725	ABC transporter, periplasmic molybdate-binding protein
HLB22_RS11730	COG1268	BioY protein
HLB22_RS11745	COG1960	acyl-CoA dehydrogenase activity
HLB22_RS11750	COG4413	Urea transporter
HLB22_RS11820	COG1757	Na H antiporter
HLB22_RS11835	COG3942	CHAP domain
HLB22_RS11870	COG1316	TRANSCRIPTIONal
HLB22_RS11900	COG1113	amino acid transport
HLB22_RS11920	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HLB22_RS11925	COG0385	Bile acid
HLB22_RS11935	COG1263	PTS System
HLB22_RS11935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLB22_RS11940	COG1737	Transcriptional regulator
HLB22_RS11960	COG1028	Short-chain dehydrogenase reductase Sdr
HLB22_RS11965	COG1473	amidohydrolase
HLB22_RS11980	COG0583	DNA-binding transcription factor activity
HLB22_RS12000	COG2258	MOSC domain
HLB22_RS12020	COG1668	transmembrane transport
HLB22_RS12025	COG4152	abc transporter atp-binding protein
HLB22_RS12030	COG3152	Membrane
HLB22_RS12040	COG0786	glutamate:sodium symporter activity
HLB22_RS12050	COG0598	Magnesium transport protein CorA
HLB22_RS12065	COG0657	acetylesterase activity
HLB22_RS12075	COG2814	Major facilitator Superfamily
HLB22_RS12080	COG1566	PFAM secretion protein HlyD family protein
HLB22_RS12090	COG2814	Major facilitator Superfamily
HLB22_RS12150	COG1131	(ABC) transporter
HLB22_RS12165	COG1620	l-lactate permease
HLB22_RS12185	COG0604	alcohol dehydrogenase
HLB22_RS12215	COG1511	domain protein
HLB22_RS12230	COG1263	PTS System
HLB22_RS12230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLB22_RS12245	COG3871	stress protein (general stress protein 26)
HLB22_RS12285	COG0789	Transcriptional regulator
HLB22_RS12305	COG2181	nitrate reductase activity
HLB22_RS12315	COG1140	nitrate reductase beta subunit
HLB22_RS12320	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HLB22_RS12330	COG2146	nitrite reductase [NAD(P)H] activity
HLB22_RS12335	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HLB22_RS12345	COG0454	-acetyltransferase
HLB22_RS12350	COG2116	formate transmembrane transporter activity
HLB22_RS12365	COG3443	Belongs to the bacterial solute-binding protein 9 family
HLB22_RS12365	COG0803	Belongs to the bacterial solute-binding protein 9 family
HLB22_RS12400	COG1126	abc transporter atp-binding protein
HLB22_RS12405	COG0765	amino acid transport
HLB22_RS12410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLB22_RS12415	COG2814	Major facilitator Superfamily
HLB22_RS12430	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HLB22_RS12470	COG0156	8-amino-7-oxononanoate synthase activity
HLB22_RS12480	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HLB22_RS12485	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HLB22_RS12500	COG1132	(ABC) transporter
HLB22_RS12520	COG1929	Belongs to the glycerate kinase type-1 family
HLB22_RS12530	COG2814	Major facilitator Superfamily
HLB22_RS12550	COG1113	amino acid transport
HLB22_RS12560	COG0531	amino acid
HLB22_RS12575	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HLB22_RS12585	COG1174	glycine betaine transport
HLB22_RS12595	COG1174	glycine betaine transport
HLB22_RS12615	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
HLB22_RS12620	COG0531	amino acid
HLB22_RS12625	COG2272	Belongs to the type-B carboxylesterase lipase family
HLB22_RS12630	COG2814	Major facilitator Superfamily
HLB22_RS12635	COG0390	transport system, permease component
HLB22_RS12640	COG4619	ABC transporter
HLB22_RS12645	COG1363	Peptidase, m42
HLB22_RS12660	COG4808	Protein conserved in bacteria
HLB22_RS12665	COG0069	glutamate synthase activity
HLB22_RS12680	COG1124	(ABC) transporter
HLB22_RS12690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLB22_RS12700	COG0747	negative chemotaxis
HLB22_RS12725	COG1028	Short-chain dehydrogenase reductase Sdr
HLB22_RS12730	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HLB22_RS12735	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HLB22_RS12770	COG2946	Replication initiation factor
HLB22_RS12810	COG1674	ftsk spoiiie
HLB22_RS12820	COG3942	CHAP domain
HLB22_RS12820	COG1388	LysM domain
HLB22_RS12840	COG2826	transposase and inactivated derivatives, IS30 family
HLB22_RS12925	COG0494	nUDIX hydrolase
HLB22_RS12965	COG1846	Transcriptional regulator
HLB22_RS12990	COG1070	Carbohydrate kinase
HLB22_RS12995	COG1802	Transcriptional regulator
HLB22_RS13000	COG0789	Transcriptional regulator
HLB22_RS13005	COG2357	RelA SpoT domain protein
HLB22_RS13010	COG4876	unkown
HLB22_RS13020	COG2271	Major facilitator Superfamily
HLB22_RS13025	COG0586	Pfam SNARE associated Golgi protein
HLB22_RS13035	COG2814	Major facilitator Superfamily
HLB22_RS13045	COG1131	(ABC) transporter
HLB22_RS13060	COG3949	Membrane
HLB22_RS13065	COG0400	carboxylic ester hydrolase activity
HLB22_RS13070	COG0346	lactoylglutathione lyase activity
HLB22_RS13075	COG1846	Transcriptional regulator
HLB22_RS13080	COG2388	GCN5-related N-acetyl-transferase
HLB22_RS13085	COG2514	catechol 2,3-dioxygenase activity
HLB22_RS13105	COG0561	phosphatase activity
HLB22_RS13110	COG1131	(ABC) transporter
HLB22_RS13120	COG3764	Sortase (surface protein transpeptidase)
HLB22_RS13140	COG1760	l-serine dehydratase
HLB22_RS13145	COG1760	l-serine dehydratase
HLB22_RS13160	COG0697	spore germination
HLB22_RS13165	COG0657	acetylesterase activity
HLB22_RS13190	COG0028	Belongs to the TPP enzyme family
HLB22_RS13205	COG0583	DNA-binding transcription factor activity
HLB22_RS13215	COG3942	CHAP domain
HLB22_RS13225	COG3425	synthase
HLB22_RS13230	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HLB22_RS13255	COG2409	Drug exporters of the RND superfamily
HLB22_RS13300	COG0436	Aminotransferase
HLB22_RS13335	COG2755	lipolytic protein G-D-S-L family
HLB22_RS13335	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HLB22_RS13340	COG0456	acetyltransferase
HLB22_RS13405	COG0596	Alpha beta hydrolase
HLB22_RS13445	COG3001	Fructosamine kinase
HLB22_RS13450	COG0167	dihydroorotate dehydrogenase activity
HLB22_RS13505	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HLB22_RS13510	COG3527	Alpha-acetolactate decarboxylase
HLB22_RS13525	COG0531	amino acid
HLB22_RS13555	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HLB22_RS13575	COG1012	belongs to the aldehyde dehydrogenase family
HLB22_RS13585	COG1510	regulation of RNA biosynthetic process
HLB22_RS13590	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HLB22_RS13615	COG2851	Citrate transporter
HLB22_RS13630	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HLB22_RS13640	COG0386	Belongs to the glutathione peroxidase family
HLB22_RS13660	COG1136	(ABC) transporter
HLB22_RS13665	COG2205	protein histidine kinase activity
HLB22_RS13670	COG0745	RESPONSE REGULATOR receiver
HLB22_RS13680	COG1785	Belongs to the alkaline phosphatase family
HLB22_RS13690	COG1846	Transcriptional regulator
HLB22_RS13735	COG1438	arginine binding
HLB22_RS13755	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLB22_RS13755	COG3711	transcriptional antiterminator
HLB22_RS13760	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLB22_RS13760	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLB22_RS13760	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLB22_RS13765	COG1482	cell wall glycoprotein biosynthetic process
HLB22_RS13775	COG1705	Flagellar rod assembly protein muramidase FlgJ
HLB22_RS13775	COG3942	CHAP domain
HLB22_RS13780	COG3433	isochorismatase activity
HLB22_RS13780	COG1535	isochorismatase
HLB22_RS13795	COG0438	transferase activity, transferring glycosyl groups
HLB22_RS13810	COG1073	alpha beta
HLB22_RS13830	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HLB22_RS13850	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HLB22_RS13940	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HLB22_RS14000	COG0471	metal ion transport
HLB22_RS14005	COG2962	Rard protein
HLB22_RS14015	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HLB22_RS14030	COG1136	(ABC) transporter
HLB22_RS14035	COG0577	efflux transmembrane transporter activity
HLB22_RS14045	COG1278	Cold shock
HLB22_RS14070	COG1475	DNA binding