locus-tag	class	description
CFN12_RS00015	COG2501	S4 domain
CFN12_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CFN12_RS00065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CFN12_RS00075	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CFN12_RS00085	COG0305	Participates in initiation and elongation during chromosome replication
CFN12_RS00120	COG4863	YycH protein
CFN12_RS00130	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CFN12_RS00135	COG0737	Belongs to the 5'-nucleotidase family
CFN12_RS00170	COG0730	response to heat
CFN12_RS00175	COG1937	Protein conserved in bacteria
CFN12_RS00180	COG2210	Belongs to the sulfur carrier protein TusA family
CFN12_RS00185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CFN12_RS00225	COG0655	NAD(P)H dehydrogenase (quinone) activity
CFN12_RS00240	COG0583	DNA-binding transcription factor activity
CFN12_RS00260	COG0823	Involved in the tonB-independent uptake of proteins
CFN12_RS00280	COG1473	amidohydrolase
CFN12_RS00290	COG1283	sodium-dependent phosphate transmembrane transporter activity
CFN12_RS00295	COG4716	Myosin-crossreactive antigen
CFN12_RS00300	COG0697	spore germination
CFN12_RS00315	COG1620	l-lactate permease
CFN12_RS00335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CFN12_RS00340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CFN12_RS00345	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CFN12_RS00355	COG2423	ornithine cyclodeaminase activity
CFN12_RS00360	COG4264	IucA IucC family
CFN12_RS00365	COG2814	Major facilitator Superfamily
CFN12_RS00370	COG4264	IucA IucC family
CFN12_RS00375	COG4264	IucA IucC family
CFN12_RS00385	COG0019	diaminopimelate decarboxylase activity
CFN12_RS00390	COG1475	DNA binding
CFN12_RS00420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CFN12_RS00425	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CFN12_RS00430	COG0438	transferase activity, transferring glycosyl groups
CFN12_RS00465	COG0813	purine-nucleoside phosphorylase activity
CFN12_RS00470	COG2814	Major facilitator Superfamily
CFN12_RS00490	COG3639	organic phosphonate transmembrane transporter activity
CFN12_RS00510	COG0737	Belongs to the 5'-nucleotidase family
CFN12_RS00540	COG1454	alcohol dehydrogenase
CFN12_RS00540	COG1012	belongs to the aldehyde dehydrogenase family
CFN12_RS00565	COG1086	Polysaccharide biosynthesis protein
CFN12_RS00575	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CFN12_RS00605	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CFN12_RS00615	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CFN12_RS00620	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CFN12_RS00630	COG2832	Protein of unknown function (DUF454)
CFN12_RS00665	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CFN12_RS00670	COG1960	acyl-CoA dehydrogenase activity
CFN12_RS00675	COG5609	conserved protein (DUF2294)
CFN12_RS00725	COG1114	Component of the transport system for branched-chain amino acids
CFN12_RS00730	COG1335	isochorismatase
CFN12_RS00735	COG3961	Belongs to the TPP enzyme family
CFN12_RS00765	COG1737	Transcriptional regulator
CFN12_RS00800	COG0601	transmembrane transport
CFN12_RS00805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CFN12_RS00815	COG0405	Gamma-glutamyltransferase
CFN12_RS00835	COG3842	ATPase activity
CFN12_RS00845	COG1175	transmembrane transport
CFN12_RS00850	COG3833	ABC-type maltose transport systems, permease component
CFN12_RS00855	COG0673	inositol 2-dehydrogenase activity
CFN12_RS00860	COG0673	inositol 2-dehydrogenase activity
CFN12_RS00870	COG1755	Isoprenylcysteine carboxyl methyltransferase
CFN12_RS00930	COG0183	Belongs to the thiolase family
CFN12_RS00940	COG1960	acyl-CoA dehydrogenase activity
CFN12_RS00945	COG0318	PFAM AMP-dependent synthetase and ligase
CFN12_RS00960	COG0747	negative chemotaxis
CFN12_RS00965	COG3189	MarR family transcriptional regulator
CFN12_RS01000	COG2190	(PTS) system
CFN12_RS01000	COG1263	PTS System
CFN12_RS01000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CFN12_RS01005	COG1957	nucleoside hydrolase
CFN12_RS01025	COG3414	Phosphotransferase system galactitol-specific IIB component
CFN12_RS01030	COG3775	system Galactitol-specific IIC component
CFN12_RS01035	COG1063	alcohol dehydrogenase
CFN12_RS01055	COG1063	alcohol dehydrogenase
CFN12_RS01060	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CFN12_RS01065	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CFN12_RS01075	COG1063	alcohol dehydrogenase
CFN12_RS01080	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CFN12_RS01115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CFN12_RS01125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CFN12_RS01125	COG2190	(PTS) system
CFN12_RS01125	COG1263	PTS System
CFN12_RS01130	COG2723	6-phospho-beta-galactosidase activity
CFN12_RS01140	COG2226	methyltransferase
CFN12_RS01200	COG1131	(ABC) transporter
CFN12_RS01230	COG3942	CHAP domain
CFN12_RS01230	COG1388	LysM domain
CFN12_RS01380	COG1114	Component of the transport system for branched-chain amino acids
CFN12_RS01390	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
CFN12_RS01400	COG0577	efflux transmembrane transporter activity
CFN12_RS01430	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CFN12_RS01435	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CFN12_RS01460	COG3314	Sporulation integral membrane protein YlbJ
CFN12_RS01485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFN12_RS01515	COG3037	sugar-specific permease SgaT UlaA
CFN12_RS01525	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFN12_RS01530	COG3711	transcriptional antiterminator
CFN12_RS01555	COG2271	Major facilitator Superfamily
CFN12_RS01560	COG0346	lactoylglutathione lyase activity
CFN12_RS01565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFN12_RS01570	COG0431	NADPH-dependent FMN reductase
CFN12_RS01585	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CFN12_RS01590	COG2822	iron ion transport
CFN12_RS01600	COG0672	)-iron permease
CFN12_RS01605	COG0805	protein transport
CFN12_RS01610	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CFN12_RS01620	COG1476	TRANSCRIPTIONal
CFN12_RS01630	COG1131	(ABC) transporter
CFN12_RS01660	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CFN12_RS01660	COG0646	methionine synthase
CFN12_RS01665	COG0626	cystathionine gamma-synthase activity
CFN12_RS01670	COG0626	cystathionine gamma-synthase activity
CFN12_RS01680	COG1475	DNA binding
CFN12_RS01685	COG0668	transmembrane transport
CFN12_RS01690	COG4481	Protein conserved in bacteria
CFN12_RS01695	COG0012	GTP binding
CFN12_RS01730	COG4974	Belongs to the 'phage' integrase family
CFN12_RS01790	COG3634	alkyl hydroperoxide reductase activity
CFN12_RS01805	COG1823	symporter activity
CFN12_RS01840	COG2233	PERMEase
CFN12_RS01880	COG3759	membrane
CFN12_RS02045	COG0523	cobalamin synthesis protein
CFN12_RS02075	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CFN12_RS02085	COG5609	conserved protein (DUF2294)
CFN12_RS02100	COG1647	Serine aminopeptidase, S33
CFN12_RS02110	COG0733	neurotransmitter:sodium symporter activity
CFN12_RS02115	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CFN12_RS02120	COG0626	cystathionine gamma-synthase activity
CFN12_RS02130	COG2011	ABC-type metal ion transport system permease component
CFN12_RS02135	COG1464	Belongs to the NlpA lipoprotein family
CFN12_RS02170	COG0583	DNA-binding transcription factor activity
CFN12_RS02175	COG0067	glutamate synthase
CFN12_RS02175	COG0070	glutamate synthase
CFN12_RS02175	COG0069	glutamate synthase activity
CFN12_RS02180	COG0493	'glutamate synthase
CFN12_RS02190	COG1263	PTS System
CFN12_RS02190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CFN12_RS02195	COG0366	Alpha amylase catalytic
CFN12_RS02200	COG2188	Transcriptional regulator
CFN12_RS02220	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CFN12_RS02260	COG1982	Orn Lys Arg decarboxylase major
CFN12_RS02270	COG3870	Protein conserved in bacteria
CFN12_RS02275	COG0470	DNA polymerase III
CFN12_RS02280	COG1774	PSP1 C-terminal conserved region
CFN12_RS02290	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CFN12_RS02300	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CFN12_RS02310	COG0084	hydrolase, TatD family'
CFN12_RS02315	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CFN12_RS02325	COG4466	Protein conserved in bacteria
CFN12_RS02335	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CFN12_RS02340	COG0251	oxidation-reduction process
CFN12_RS02385	COG2244	polysaccharide biosynthetic process
CFN12_RS02390	COG3956	TIGRFAM MazG family protein
CFN12_RS02395	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CFN12_RS02405	COG1098	S1 RNA binding domain
CFN12_RS02420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CFN12_RS02445	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CFN12_RS02540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CFN12_RS02555	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CFN12_RS02565	COG3880	PFAM UvrB UvrC protein
CFN12_RS02580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CFN12_RS02585	COG4956	integral membrane protein (PIN domain superfamily)
CFN12_RS02610	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CFN12_RS02670	COG2813	Specifically methylates the guanine in position
CFN12_RS02710	COG1473	amidohydrolase
CFN12_RS02745	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CFN12_RS02750	COG1428	Deoxynucleoside kinase
CFN12_RS02755	COG1428	Deoxynucleoside kinase
CFN12_RS02765	COG0561	phosphatase activity
CFN12_RS02810	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CFN12_RS02825	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CFN12_RS02925	COG0095	Lipoate-protein ligase
CFN12_RS02930	COG0083	homoserine kinase activity
CFN12_RS02950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CFN12_RS03045	COG0667	Aldo Keto reductase
CFN12_RS03050	COG0655	NAD(P)H dehydrogenase (quinone) activity
CFN12_RS03060	COG1078	dGTPase activity
CFN12_RS03100	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CFN12_RS03105	COG4139	cobalamin transport
CFN12_RS03155	COG4974	Belongs to the 'phage' integrase family
CFN12_RS03200	COG0803	Belongs to the bacterial solute-binding protein 9 family
CFN12_RS03205	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CFN12_RS03210	COG1121	(ABC) transporter
CFN12_RS03215	COG1321	iron dependent repressor
CFN12_RS03225	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CFN12_RS03235	COG1682	transport, permease protein
CFN12_RS03240	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CFN12_RS03245	COG1216	Glycosyl transferase, family 2
CFN12_RS03250	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CFN12_RS03255	COG1686	Belongs to the peptidase S11 family
CFN12_RS03260	COG1132	(ABC) transporter
CFN12_RS03265	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CFN12_RS03275	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CFN12_RS03280	COG1120	ATPase activity
CFN12_RS03285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CFN12_RS03290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CFN12_RS03295	COG2376	Dihydroxyacetone kinase
CFN12_RS03305	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CFN12_RS03315	COG3949	Membrane
CFN12_RS03340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CFN12_RS03355	COG1136	(ABC) transporter
CFN12_RS03360	COG0577	efflux transmembrane transporter activity
CFN12_RS03365	COG1392	Phosphate transport regulator
CFN12_RS03370	COG0306	phosphate transporter
CFN12_RS03375	COG1388	LysM domain
CFN12_RS03375	COG3942	CHAP domain
CFN12_RS03385	COG4977	sequence-specific DNA binding
CFN12_RS03385	COG1917	Cupin 2, conserved barrel domain protein
CFN12_RS03415	COG0583	DNA-binding transcription factor activity
CFN12_RS03420	COG2814	Major facilitator Superfamily
CFN12_RS03425	COG2839	Protein conserved in bacteria
CFN12_RS03455	COG1611	Belongs to the LOG family
CFN12_RS03475	COG4988	ABC transporter
CFN12_RS03480	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CFN12_RS03490	COG0523	cobalamin synthesis protein
CFN12_RS03495	COG4989	oxidoreductase activity
CFN12_RS03505	COG0471	metal ion transport
CFN12_RS03510	COG0415	Belongs to the DNA photolyase family
CFN12_RS03540	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CFN12_RS03545	COG1349	DNA-binding transcription factor activity
CFN12_RS03550	COG1105	Belongs to the carbohydrate kinase PfkB family
CFN12_RS03555	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CFN12_RS03555	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFN12_RS03555	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CFN12_RS03560	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CFN12_RS03565	COG1253	flavin adenine dinucleotide binding
CFN12_RS03570	COG0656	L-ascorbic acid biosynthetic process
CFN12_RS03575	COG0463	Glycosyl transferase, family 2
CFN12_RS03610	COG0720	synthase
CFN12_RS03620	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CFN12_RS03620	COG0512	Glutamine amidotransferase of anthranilate synthase
CFN12_RS03625	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CFN12_RS03655	COG0488	(ABC) transporter
CFN12_RS03660	COG0514	ATP-dependent DNA helicase (RecQ)
CFN12_RS03665	COG1125	glycine betaine transport
CFN12_RS03665	COG0517	IMP dehydrogenase activity
CFN12_RS03670	COG1174	glycine betaine transport
CFN12_RS03700	COG3104	oligopeptide transport
CFN12_RS03730	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CFN12_RS03735	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CFN12_RS03750	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CFN12_RS03755	COG4605	iron ion homeostasis
CFN12_RS03760	COG4604	ABC transporter, ATP-binding protein
CFN12_RS03765	COG4607	ABC-type enterochelin transport system periplasmic component
CFN12_RS03820	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CFN12_RS03825	COG1739	Uncharacterized protein family UPF0029
CFN12_RS03835	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CFN12_RS03840	COG1040	competence protein
CFN12_RS03870	COG1388	LysM domain
CFN12_RS03870	COG3942	CHAP domain
CFN12_RS03930	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CFN12_RS03995	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CFN12_RS04000	COG1647	Serine aminopeptidase, S33
CFN12_RS04005	COG0557	exoribonuclease II activity
CFN12_RS04080	COG1278	Cold shock
CFN12_RS04120	COG0406	alpha-ribazole phosphatase activity
CFN12_RS04125	COG1279	arginine transmembrane transporter activity
CFN12_RS04150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CFN12_RS04155	COG1393	Belongs to the ArsC family
CFN12_RS04170	COG3878	Protein conserved in bacteria
CFN12_RS04180	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CFN12_RS04195	COG2011	ABC-type metal ion transport system permease component
CFN12_RS04200	COG1464	Belongs to the NlpA lipoprotein family
CFN12_RS04215	COG0396	ATPase activity
CFN12_RS04220	COG0719	Fe-S assembly protein
CFN12_RS04230	COG0822	iron-sulfur transferase activity
CFN12_RS04255	COG1253	flavin adenine dinucleotide binding
CFN12_RS04270	COG1801	Protein of unknown function DUF72
CFN12_RS04275	COG0730	response to heat
CFN12_RS04290	COG4470	Protein conserved in bacteria
CFN12_RS04300	COG2445	Protein of unknown function DUF86
CFN12_RS04330	COG1696	Membrane protein involved in D-alanine export
CFN12_RS04340	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CFN12_RS04345	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CFN12_RS04350	COG4837	Protein of unknown function (DUF1462)
CFN12_RS04355	COG1252	NADH dehydrogenase
CFN12_RS04365	COG0316	Belongs to the HesB IscA family
CFN12_RS04375	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CFN12_RS04380	COG2056	Na+-H+ antiporter family
CFN12_RS04385	COG2050	protein possibly involved in aromatic compounds catabolism
CFN12_RS04440	COG1098	S1 RNA binding domain
CFN12_RS04445	COG1902	pentaerythritol trinitrate reductase activity
CFN12_RS04465	COG0584	glycerophosphoryl diester phosphodiesterase
CFN12_RS04485	COG0398	Pfam SNARE associated Golgi protein
CFN12_RS04525	COG0561	phosphatase activity
CFN12_RS04565	COG1881	PFAM PEBP family protein
CFN12_RS04595	COG0601	transmembrane transport
CFN12_RS04600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CFN12_RS04605	COG0444	Belongs to the ABC transporter superfamily
CFN12_RS04610	COG4608	Belongs to the ABC transporter superfamily
CFN12_RS04615	COG4166	transmembrane transport
CFN12_RS04620	COG0747	negative chemotaxis
CFN12_RS04625	COG0444	Belongs to the ABC transporter superfamily
CFN12_RS04630	COG4608	Belongs to the ABC transporter superfamily
CFN12_RS04635	COG0601	transmembrane transport
CFN12_RS04640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CFN12_RS04670	COG1164	Oligoendopeptidase f
CFN12_RS04680	COG2346	COG2346, Truncated hemoglobins
CFN12_RS04695	COG2357	RelA SpoT domain protein
CFN12_RS04705	COG0564	pseudouridine synthase activity
CFN12_RS04710	COG2239	Acts as a magnesium transporter
CFN12_RS04715	COG0475	glutathione-regulated potassium exporter activity
CFN12_RS04715	COG0569	domain protein
CFN12_RS04725	COG0628	permease
CFN12_RS04730	COG1115	amino acid carrier protein
CFN12_RS04770	COG0861	Integral membrane protein TerC family
CFN12_RS04780	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CFN12_RS04785	COG0737	Belongs to the 5'-nucleotidase family
CFN12_RS04800	COG4903	ComK protein
CFN12_RS04815	COG4873	Protein conserved in bacteria
CFN12_RS04875	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CFN12_RS04885	COG2314	TM2 domain
CFN12_RS04890	COG0456	acetyltransferase
CFN12_RS04895	COG1575	Belongs to the MenA family. Type 1 subfamily
CFN12_RS04905	COG1169	isochorismate synthase
CFN12_RS04915	COG2267	carboxylic ester hydrolase activity
CFN12_RS04940	COG0436	Aminotransferase
CFN12_RS04945	COG3594	Acyltransferase
CFN12_RS04975	COG1316	TRANSCRIPTIONal
CFN12_RS04980	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CFN12_RS05025	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CFN12_RS05040	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CFN12_RS05070	COG0138	bifunctional purine biosynthesis protein purh
CFN12_RS05080	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CFN12_RS05085	COG4172	Belongs to the ABC transporter superfamily
CFN12_RS05090	COG4721	ABC-type cobalt transport system, permease component
CFN12_RS05115	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CFN12_RS05140	COG1271	oxidase subunit
CFN12_RS05145	COG1294	oxidase, subunit
CFN12_RS05150	COG0569	domain protein
CFN12_RS05215	COG1176	ABC-type spermidine putrescine transport system, permease component I
CFN12_RS05220	COG1177	transmembrane transport
CFN12_RS05225	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CFN12_RS05250	COG0483	inositol monophosphate 1-phosphatase activity
CFN12_RS05260	COG1217	gtp-binding protein TYPA
CFN12_RS05270	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CFN12_RS05280	COG0772	Belongs to the SEDS family
CFN12_RS05315	COG3679	Belongs to the UPF0342 family
CFN12_RS05335	COG0742	ribosomal rna small subunit methyltransferase
CFN12_RS05420	COG0629	single-stranded DNA binding
CFN12_RS05440	COG1484	DNA-dependent DNA replication
CFN12_RS05550	COG1783	phage Terminase large subunit
CFN12_RS05680	COG1388	LysM domain
CFN12_RS05680	COG5632	N-Acetylmuramoyl-L-alanine amidase
CFN12_RS05725	COG4509	Sortase family
CFN12_RS05740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CFN12_RS05775	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CFN12_RS05775	COG1796	DNA polymerase
CFN12_RS05800	COG2009	succinate dehydrogenase
CFN12_RS05805	COG1053	succinate dehydrogenase
CFN12_RS05810	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CFN12_RS05925	COG1288	antiporter activity
CFN12_RS05960	COG1011	Hydrolase
CFN12_RS05985	COG4839	cell division protein FtsL
CFN12_RS05990	COG0768	penicillin binding
CFN12_RS06005	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CFN12_RS06010	COG0849	cell division
CFN12_RS06025	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CFN12_RS06035	COG0762	integral membrane protein
CFN12_RS06040	COG2302	S4 RNA-binding domain
CFN12_RS06045	COG3599	regulation of cell shape
CFN12_RS06055	COG2514	catechol 2,3-dioxygenase activity
CFN12_RS06075	COG0564	pseudouridine synthase activity
CFN12_RS06085	COG2233	PERMEase
CFN12_RS06130	COG1293	RNA-binding protein homologous to eukaryotic snRNP
CFN12_RS06145	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CFN12_RS06150	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CFN12_RS06160	COG2314	TM2 domain
CFN12_RS06175	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CFN12_RS06175	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CFN12_RS06185	COG0631	protein serine/threonine phosphatase activity
CFN12_RS06200	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CFN12_RS06215	COG1302	Protein conserved in bacteria
CFN12_RS06225	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CFN12_RS06265	COG1196	nuclear chromosome segregation
CFN12_RS06270	COG0552	protein localization to endoplasmic reticulum
CFN12_RS06280	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CFN12_RS06340	COG0758	DNA mediated transformation
CFN12_RS06440	COG0195	Participates in both transcription termination and antitermination
CFN12_RS06445	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CFN12_RS06470	COG0196	riboflavin kinase activity
CFN12_RS06500	COG2188	Transcriptional regulator
CFN12_RS06505	COG0612	Peptidase, M16
CFN12_RS06510	COG0612	Peptidase, M16
CFN12_RS06515	COG0300	oxidoreductase activity
CFN12_RS06535	COG1058	Belongs to the CinA family
CFN12_RS06535	COG1546	Belongs to the CinA family
CFN12_RS06555	COG1692	metallophosphoesterase
CFN12_RS06560	COG0674	pyruvate-flavodoxin oxidoreductase activity
CFN12_RS06560	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CFN12_RS06565	COG1013	pyruvate-flavodoxin oxidoreductase activity
CFN12_RS06600	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CFN12_RS06605	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CFN12_RS06630	COG1923	regulation of RNA biosynthetic process
CFN12_RS06640	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CFN12_RS06645	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CFN12_RS06650	COG0789	Transcriptional regulator
CFN12_RS06745	COG1131	(ABC) transporter
CFN12_RS06760	COG2197	response regulator
CFN12_RS06770	COG1525	nuclease
CFN12_RS06785	COG0527	aspartate kinase activity
CFN12_RS06790	COG0460	homoserine dehydrogenase
CFN12_RS06795	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CFN12_RS06820	COG0833	amino acid
CFN12_RS06850	COG2340	Cysteine-rich secretory protein family
CFN12_RS06885	COG4846	Membrane protein involved in cytochrome C biogenesis
CFN12_RS06905	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CFN12_RS06920	COG0824	Thioesterase
CFN12_RS06960	COG1115	amino acid carrier protein
CFN12_RS06975	COG0628	permease
CFN12_RS06980	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CFN12_RS06980	COG0392	lysyltransferase activity
CFN12_RS07000	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CFN12_RS07010	COG1363	Peptidase, m42
CFN12_RS07015	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CFN12_RS07020	COG0512	Glutamine amidotransferase of anthranilate synthase
CFN12_RS07060	COG0561	phosphatase activity
CFN12_RS07105	COG0704	Plays a role in the regulation of phosphate uptake
CFN12_RS07115	COG0581	inorganic phosphate transmembrane transporter activity
CFN12_RS07120	COG0573	inorganic phosphate transmembrane transporter activity
CFN12_RS07140	COG0488	(ABC) transporter
CFN12_RS07145	COG0527	aspartate kinase activity
CFN12_RS07150	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CFN12_RS07230	COG4548	von Willebrand factor, type A
CFN12_RS07235	COG0714	Associated with various cellular activities
CFN12_RS07285	COG0671	phosphoesterase, PA-phosphatase related
CFN12_RS07360	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CFN12_RS07385	COG0531	amino acid
CFN12_RS07400	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CFN12_RS07405	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CFN12_RS07420	COG0116	Belongs to the methyltransferase superfamily
CFN12_RS07460	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CFN12_RS07460	COG4499	WXG100 protein secretion system (Wss), protein YukC
CFN12_RS07470	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CFN12_RS07475	COG3935	DnaD domain protein
CFN12_RS07500	COG0438	transferase activity, transferring glycosyl groups
CFN12_RS07505	COG1694	Mazg nucleotide pyrophosphohydrolase
CFN12_RS07510	COG2738	Putative neutral zinc metallopeptidase
CFN12_RS07515	COG4347	Protein of unknown function (DUF1405)
CFN12_RS07555	COG0142	geranyltranstransferase activity
CFN12_RS07620	COG0492	ferredoxin-NADP+ reductase activity
CFN12_RS07635	COG0514	ATP-dependent DNA helicase (RecQ)
CFN12_RS07645	COG1141	Ferredoxin
CFN12_RS07695	COG1388	LysM domain
CFN12_RS07695	COG0860	N-Acetylmuramoyl-L-alanine amidase
CFN12_RS07745	COG3953	SLT domain
CFN12_RS07745	COG5280	Phage tail tape measure protein TP901
CFN12_RS07830	COG2826	transposase and inactivated derivatives, IS30 family
CFN12_RS07860	COG1674	ftsk spoiiie
CFN12_RS07875	COG0433	COG0433 Predicted ATPase
CFN12_RS07895	COG2946	Replication initiation factor
CFN12_RS07955	COG0756	dUTP diphosphatase activity
CFN12_RS08090	COG0582	viral genome integration into host DNA
CFN12_RS08105	COG5002	protein histidine kinase activity
CFN12_RS08110	COG0745	RESPONSE REGULATOR receiver
CFN12_RS08115	COG1187	pseudouridine synthase activity
CFN12_RS08140	COG0735	belongs to the Fur family
CFN12_RS08145	COG0494	nUDIX hydrolase
CFN12_RS08150	COG0667	Aldo Keto reductase
CFN12_RS08160	COG4221	oxidoreductase activity
CFN12_RS08175	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CFN12_RS08185	COG0366	Alpha amylase catalytic
CFN12_RS08190	COG1609	Transcriptional regulator
CFN12_RS08210	COG2195	Cleaves the N-terminal amino acid of tripeptides
CFN12_RS08220	COG4129	membrane
CFN12_RS08230	COG0508	dehydrogenase complex catalyzes the overall conversion of
CFN12_RS08235	COG0022	dehydrogenase e1 component
CFN12_RS08240	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CFN12_RS08245	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CFN12_RS08250	COG0497	DNA recombination
CFN12_RS08280	COG1302	Protein conserved in bacteria
CFN12_RS08285	COG0439	Biotin carboxylase
CFN12_RS08290	COG0511	ligase activity, forming carbon-carbon bonds
CFN12_RS08300	COG0006	proline dipeptidase activity
CFN12_RS08315	COG0095	Lipoate-protein ligase
CFN12_RS08320	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CFN12_RS08365	COG4537	Required for transformation and DNA binding
CFN12_RS08370	COG1459	type II secretion system
CFN12_RS08375	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CFN12_RS08380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CFN12_RS08385	COG0011	TIGRFAM Protein of
CFN12_RS08390	COG1940	carbohydrate kinase activity
CFN12_RS08395	COG4483	Protein conserved in bacteria
CFN12_RS08405	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CFN12_RS08415	COG0768	penicillin binding
CFN12_RS08430	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CFN12_RS08435	COG1121	(ABC) transporter
CFN12_RS08445	COG0513	Belongs to the DEAD box helicase family
CFN12_RS08455	COG2384	SAM-dependent methyltransferase
CFN12_RS08475	COG0517	IMP dehydrogenase activity
CFN12_RS08495	COG0295	cytidine deaminase activity
CFN12_RS08510	COG1702	phosphate starvation-inducible protein PhoH
CFN12_RS08525	COG1030	water channel activity
CFN12_RS08535	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CFN12_RS08540	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CFN12_RS08570	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CFN12_RS08590	COG1466	dna polymerase III delta subunit
CFN12_RS08595	COG2333	competence protein COMEC
CFN12_RS08595	COG0658	competence protein
CFN12_RS08600	COG2131	deaminase
CFN12_RS08610	COG2226	methyltransferase
CFN12_RS08615	COG0799	negative regulation of ribosome biogenesis
CFN12_RS08620	COG1713	HD superfamily hydrolase involved in NAD metabolism
CFN12_RS08630	COG1534	Rna-binding protein
CFN12_RS08640	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CFN12_RS08645	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CFN12_RS08665	COG3177	Filamentation induced by cAMP protein fic
CFN12_RS08670	COG1914	H( )-stimulated, divalent metal cation uptake system
CFN12_RS08680	COG0439	Biotin carboxylase
CFN12_RS08685	COG0511	ligase activity, forming carbon-carbon bonds
CFN12_RS08690	COG1984	allophanate hydrolase subunit 2
CFN12_RS08695	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CFN12_RS08710	COG0826	peptidase U32
CFN12_RS08715	COG0826	peptidase U32
CFN12_RS08745	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CFN12_RS08760	COG1104	cysteine desulfurase activity
CFN12_RS08765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFN12_RS08780	COG1959	2 iron, 2 sulfur cluster binding
CFN12_RS08785	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CFN12_RS08790	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CFN12_RS08835	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CFN12_RS08835	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CFN12_RS08840	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CFN12_RS08840	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CFN12_RS08845	COG1862	Preprotein translocase
CFN12_RS08885	COG2868	ribosomal protein
CFN12_RS08930	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CFN12_RS08940	COG0285	dihydrofolate synthase activity
CFN12_RS08950	COG2818	Glycosylase
CFN12_RS08985	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CFN12_RS09020	COG4112	unkown
CFN12_RS09045	COG0833	amino acid
CFN12_RS09060	COG1484	DNA-dependent DNA replication
CFN12_RS09090	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CFN12_RS09090	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CFN12_RS09100	COG5002	protein histidine kinase activity
CFN12_RS09105	COG0745	RESPONSE REGULATOR receiver
CFN12_RS09120	COG0372	Belongs to the citrate synthase family
CFN12_RS09125	COG1113	amino acid transport
CFN12_RS09155	COG0281	malic enzyme
CFN12_RS09165	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CFN12_RS09175	COG4109	DRTGG domain
CFN12_RS09215	COG0827	DNA restriction-modification system
CFN12_RS09235	COG1104	cysteine desulfurase activity
CFN12_RS09250	COG1956	GAF domain-containing protein
CFN12_RS09270	COG0584	glycerophosphoryl diester phosphodiesterase
CFN12_RS09275	COG1764	response to oxidative stress
CFN12_RS09280	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CFN12_RS09285	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CFN12_RS09300	COG1263	PTS System
CFN12_RS09300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CFN12_RS09305	COG0204	Acyl-transferase
CFN12_RS09310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CFN12_RS09345	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CFN12_RS09350	COG0454	-acetyltransferase
CFN12_RS09370	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CFN12_RS09370	COG1605	Chorismate mutase
CFN12_RS09395	COG1674	ftsk spoiiie
CFN12_RS09400	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CFN12_RS09410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CFN12_RS09415	COG1363	Peptidase, m42
CFN12_RS09425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CFN12_RS09435	COG0510	thiamine kinase activity
CFN12_RS09455	COG1187	pseudouridine synthase activity
CFN12_RS09460	COG2244	polysaccharide biosynthetic process
CFN12_RS09465	COG2081	HI0933 family
CFN12_RS09485	COG2814	Major facilitator Superfamily
CFN12_RS09490	COG1242	4 iron, 4 sulfur cluster binding
CFN12_RS09495	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CFN12_RS09510	COG2267	carboxylic ester hydrolase activity
CFN12_RS09545	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CFN12_RS09545	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CFN12_RS09570	COG5632	N-Acetylmuramoyl-L-alanine amidase
CFN12_RS09570	COG3266	domain, Protein
CFN12_RS09570	COG4193	domain, Protein
CFN12_RS09600	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CFN12_RS09625	COG0656	L-ascorbic acid biosynthetic process
CFN12_RS09650	COG1506	peptidase
CFN12_RS09815	COG1131	(ABC) transporter
CFN12_RS09935	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CFN12_RS09965	COG1131	(ABC) transporter
CFN12_RS09970	COG0537	adenosine 5'-monophosphoramidase activity
CFN12_RS10005	COG0420	3'-5' exonuclease activity
CFN12_RS10035	COG2197	response regulator
CFN12_RS10040	COG2203	Gaf domain
CFN12_RS10040	COG4585	Histidine kinase
CFN12_RS10045	COG0564	pseudouridine synthase activity
CFN12_RS10085	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CFN12_RS10090	COG1126	abc transporter atp-binding protein
CFN12_RS10095	COG0765	amino acid transport
CFN12_RS10275	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CFN12_RS10280	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CFN12_RS10290	COG4129	membrane
CFN12_RS10315	COG1988	membrane-bound metal-dependent
CFN12_RS10330	COG1388	LysM domain
CFN12_RS10330	COG1134	teichoic acid transport
CFN12_RS10360	COG0535	radical SAM domain protein
CFN12_RS10365	COG1607	acyl-coa hydrolase
CFN12_RS10370	COG2309	aminopeptidase activity
CFN12_RS10390	COG1295	ribonuclease BN
CFN12_RS10395	COG2197	response regulator
CFN12_RS10520	COG4851	CamS sex pheromone cAM373 precursor
CFN12_RS10530	COG0210	DNA helicase
CFN12_RS10540	COG4496	protein, YerC YecD
CFN12_RS10580	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CFN12_RS10590	COG0077	Prephenate dehydratase
CFN12_RS10600	COG0471	metal ion transport
CFN12_RS10610	COG1335	isochorismatase
CFN12_RS10625	COG1012	belongs to the aldehyde dehydrogenase family
CFN12_RS10680	COG1131	(ABC) transporter
CFN12_RS10695	COG1725	Transcriptional regulator
CFN12_RS10750	COG0860	N-Acetylmuramoyl-L-alanine amidase
CFN12_RS10750	COG1388	LysM domain
CFN12_RS10775	COG1388	LysM domain
CFN12_RS10775	COG5632	N-Acetylmuramoyl-L-alanine amidase
CFN12_RS10820	COG0739	heme binding
CFN12_RS10870	COG0740	serine-type endopeptidase activity
CFN12_RS11085	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CFN12_RS11090	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CFN12_RS11095	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CFN12_RS11115	COG5484	DNA packaging
CFN12_RS11115	COG3728	DNA packaging
CFN12_RS11195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CFN12_RS11200	COG1621	beta-fructofuranosidase activity
CFN12_RS11205	COG1609	Transcriptional regulator
CFN12_RS11210	COG0004	ammonium transporteR
CFN12_RS11215	COG0425	Belongs to the sulfur carrier protein TusA family
CFN12_RS11220	COG2391	methyltransferase activity
CFN12_RS11230	COG0488	(ABC) transporter
CFN12_RS11240	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CFN12_RS11250	COG0456	acetyltransferase
CFN12_RS11255	COG1214	PFAM Peptidase M22, glycoprotease
CFN12_RS11260	COG0802	atpase or kinase
CFN12_RS11275	COG0028	Belongs to the TPP enzyme family
CFN12_RS11350	COG2183	response to ionizing radiation
CFN12_RS11355	COG1191	sigma factor activity
CFN12_RS11365	COG1366	Belongs to the anti-sigma-factor antagonist family
CFN12_RS11370	COG2208	phosphoserine phosphatase activity
CFN12_RS11405	COG3428	Bacterial PH domain
CFN12_RS11435	COG2205	protein histidine kinase activity
CFN12_RS11440	COG0745	RESPONSE REGULATOR receiver
CFN12_RS11450	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CFN12_RS11460	COG0772	Belongs to the SEDS family
CFN12_RS11475	COG1937	Protein conserved in bacteria
CFN12_RS11485	COG1418	mRNA catabolic process
CFN12_RS11535	COG0629	single-stranded DNA binding
CFN12_RS11610	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CFN12_RS11635	COG0009	L-threonylcarbamoyladenylate synthase
CFN12_RS11640	COG2890	protein-(glutamine-N5) methyltransferase activity
CFN12_RS11665	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CFN12_RS11705	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CFN12_RS11755	COG0813	purine-nucleoside phosphorylase activity
CFN12_RS11760	COG0783	Belongs to the Dps family
CFN12_RS11780	COG1482	cell wall glycoprotein biosynthetic process
CFN12_RS11785	COG0702	epimerase
CFN12_RS11790	COG0640	Transcriptional regulator
CFN12_RS11825	COG0561	phosphatase activity
CFN12_RS11830	COG1119	ATPase activity
CFN12_RS11845	COG3711	transcriptional antiterminator
CFN12_RS11875	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CFN12_RS11950	COG0489	protein tyrosine kinase activity
CFN12_RS11955	COG2814	Major facilitator Superfamily
CFN12_RS11970	COG1272	protein, Hemolysin III
CFN12_RS11980	COG1988	membrane-bound metal-dependent
CFN12_RS11990	COG3314	Sporulation integral membrane protein YlbJ
CFN12_RS11995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CFN12_RS12000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CFN12_RS12005	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CFN12_RS12015	COG3457	Alanine racemase
CFN12_RS12020	COG4264	IucA IucC family
CFN12_RS12025	COG2814	Major facilitator Superfamily
CFN12_RS12055	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CFN12_RS12065	COG2130	NADP-dependent
CFN12_RS12110	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CFN12_RS12130	COG0656	L-ascorbic acid biosynthetic process
CFN12_RS12135	COG0789	Transcriptional regulator
CFN12_RS12145	COG5492	domain, Protein
CFN12_RS12165	COG3527	Alpha-acetolactate decarboxylase
CFN12_RS12170	COG0028	Belongs to the TPP enzyme family
CFN12_RS12190	COG0542	response to heat
CFN12_RS12275	COG0201	protein transport
CFN12_RS12390	COG2252	PERMEase
CFN12_RS12435	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CFN12_RS12505	COG1763	Mo-molybdopterin cofactor biosynthetic process
CFN12_RS12525	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CFN12_RS12530	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CFN12_RS12535	COG4149	molybdate abc transporter
CFN12_RS12540	COG0725	ABC transporter, periplasmic molybdate-binding protein
CFN12_RS12555	COG1268	BioY protein
CFN12_RS12570	COG1960	acyl-CoA dehydrogenase activity
CFN12_RS12575	COG4413	Urea transporter
CFN12_RS12640	COG3942	CHAP domain
CFN12_RS12650	COG1757	Na H antiporter
CFN12_RS12665	COG3942	CHAP domain
CFN12_RS12740	COG1113	amino acid transport
CFN12_RS12760	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CFN12_RS12765	COG0385	Bile acid
CFN12_RS12775	COG1263	PTS System
CFN12_RS12775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CFN12_RS12780	COG1737	Transcriptional regulator
CFN12_RS12800	COG1028	Short-chain dehydrogenase reductase Sdr
CFN12_RS12805	COG1473	amidohydrolase
CFN12_RS12820	COG0583	DNA-binding transcription factor activity
CFN12_RS12845	COG2258	MOSC domain
CFN12_RS12865	COG1668	transmembrane transport
CFN12_RS12870	COG4152	abc transporter atp-binding protein
CFN12_RS12875	COG3152	Membrane
CFN12_RS12890	COG0786	glutamate:sodium symporter activity
CFN12_RS12900	COG0598	Magnesium transport protein CorA
CFN12_RS12915	COG0657	acetylesterase activity
CFN12_RS12925	COG2814	Major facilitator Superfamily
CFN12_RS12930	COG1566	PFAM secretion protein HlyD family protein
CFN12_RS12940	COG2814	Major facilitator Superfamily
CFN12_RS13010	COG1620	l-lactate permease
CFN12_RS13030	COG0604	alcohol dehydrogenase
CFN12_RS13035	COG0456	acetyltransferase
CFN12_RS13060	COG1511	domain protein
CFN12_RS13075	COG1263	PTS System
CFN12_RS13075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CFN12_RS13090	COG3871	stress protein (general stress protein 26)
CFN12_RS13135	COG0789	Transcriptional regulator
CFN12_RS13155	COG2181	nitrate reductase activity
CFN12_RS13165	COG1140	nitrate reductase beta subunit
CFN12_RS13170	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CFN12_RS13180	COG2146	nitrite reductase [NAD(P)H] activity
CFN12_RS13185	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CFN12_RS13195	COG0454	-acetyltransferase
CFN12_RS13200	COG2116	formate transmembrane transporter activity
CFN12_RS13215	COG0803	Belongs to the bacterial solute-binding protein 9 family
CFN12_RS13215	COG3443	Belongs to the bacterial solute-binding protein 9 family
CFN12_RS13255	COG1126	abc transporter atp-binding protein
CFN12_RS13260	COG0765	amino acid transport
CFN12_RS13265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CFN12_RS13270	COG2814	Major facilitator Superfamily
CFN12_RS13290	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CFN12_RS13340	COG0156	8-amino-7-oxononanoate synthase activity
CFN12_RS13355	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CFN12_RS13370	COG1132	(ABC) transporter
CFN12_RS13375	COG2375	cellular response to nickel ion
CFN12_RS13375	COG1132	(ABC) transporter
CFN12_RS13395	COG1929	Belongs to the glycerate kinase type-1 family
CFN12_RS13405	COG2814	Major facilitator Superfamily
CFN12_RS13425	COG1113	amino acid transport
CFN12_RS13440	COG0531	amino acid
CFN12_RS13465	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CFN12_RS13475	COG1174	glycine betaine transport
CFN12_RS13485	COG1174	glycine betaine transport
CFN12_RS13505	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
CFN12_RS13515	COG0531	amino acid
CFN12_RS13520	COG2272	Belongs to the type-B carboxylesterase lipase family
CFN12_RS13525	COG2814	Major facilitator Superfamily
CFN12_RS13530	COG0390	transport system, permease component
CFN12_RS13535	COG4619	ABC transporter
CFN12_RS13540	COG1363	Peptidase, m42
CFN12_RS13560	COG4808	Protein conserved in bacteria
CFN12_RS13565	COG0069	glutamate synthase activity
CFN12_RS13580	COG1124	(ABC) transporter
CFN12_RS13585	COG0444	Belongs to the ABC transporter superfamily
CFN12_RS13590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CFN12_RS13595	COG0601	transmembrane transport
CFN12_RS13600	COG0747	negative chemotaxis
CFN12_RS13630	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CFN12_RS13635	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CFN12_RS13725	COG0494	nUDIX hydrolase
CFN12_RS13765	COG1846	Transcriptional regulator
CFN12_RS13770	COG1846	Transcriptional regulator
CFN12_RS13805	COG1070	Carbohydrate kinase
CFN12_RS13810	COG1802	Transcriptional regulator
CFN12_RS13815	COG0789	Transcriptional regulator
CFN12_RS13820	COG2357	RelA SpoT domain protein
CFN12_RS13825	COG4876	unkown
CFN12_RS13835	COG2271	Major facilitator Superfamily
CFN12_RS13840	COG0586	Pfam SNARE associated Golgi protein
CFN12_RS13850	COG2814	Major facilitator Superfamily
CFN12_RS13855	COG1846	Transcriptional regulator
CFN12_RS13870	COG1131	(ABC) transporter
CFN12_RS13890	COG0400	carboxylic ester hydrolase activity
CFN12_RS13895	COG0346	lactoylglutathione lyase activity
CFN12_RS13900	COG1846	Transcriptional regulator
CFN12_RS13910	COG2514	catechol 2,3-dioxygenase activity
CFN12_RS13925	COG0561	phosphatase activity
CFN12_RS13930	COG1131	(ABC) transporter
CFN12_RS13940	COG3764	Sortase (surface protein transpeptidase)
CFN12_RS13960	COG1760	l-serine dehydratase
CFN12_RS13965	COG1760	l-serine dehydratase
CFN12_RS13980	COG0697	spore germination
CFN12_RS13985	COG0657	acetylesterase activity
CFN12_RS14005	COG0028	Belongs to the TPP enzyme family
CFN12_RS14020	COG0583	DNA-binding transcription factor activity
CFN12_RS14030	COG3942	CHAP domain
CFN12_RS14055	COG3425	synthase
CFN12_RS14060	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CFN12_RS14065	COG0542	response to heat
CFN12_RS14085	COG2409	Drug exporters of the RND superfamily
CFN12_RS14130	COG0436	Aminotransferase
CFN12_RS14160	COG3942	CHAP domain
CFN12_RS14165	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CFN12_RS14165	COG2755	lipolytic protein G-D-S-L family
CFN12_RS14235	COG0596	Alpha beta hydrolase
CFN12_RS14275	COG3001	Fructosamine kinase
CFN12_RS14280	COG0167	dihydroorotate dehydrogenase activity
CFN12_RS14330	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CFN12_RS14335	COG3527	Alpha-acetolactate decarboxylase
CFN12_RS14350	COG0531	amino acid
CFN12_RS14380	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CFN12_RS14400	COG1012	belongs to the aldehyde dehydrogenase family
CFN12_RS14410	COG1510	regulation of RNA biosynthetic process
CFN12_RS14420	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CFN12_RS14445	COG2851	Citrate transporter
CFN12_RS14460	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CFN12_RS14470	COG0386	Belongs to the glutathione peroxidase family
CFN12_RS14495	COG1136	(ABC) transporter
CFN12_RS14500	COG2205	protein histidine kinase activity
CFN12_RS14505	COG0745	RESPONSE REGULATOR receiver
CFN12_RS14515	COG1785	Belongs to the alkaline phosphatase family
CFN12_RS14525	COG1846	Transcriptional regulator
CFN12_RS14570	COG1438	arginine binding
CFN12_RS14590	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFN12_RS14590	COG3711	transcriptional antiterminator
CFN12_RS14595	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFN12_RS14595	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CFN12_RS14595	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CFN12_RS14600	COG1482	cell wall glycoprotein biosynthetic process
CFN12_RS14610	COG3942	CHAP domain
CFN12_RS14610	COG1705	Flagellar rod assembly protein muramidase FlgJ
CFN12_RS14615	COG3433	isochorismatase activity
CFN12_RS14615	COG1535	isochorismatase
CFN12_RS14630	COG0438	transferase activity, transferring glycosyl groups
CFN12_RS14645	COG1073	alpha beta
CFN12_RS14665	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CFN12_RS14685	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CFN12_RS14745	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CFN12_RS14780	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CFN12_RS14865	COG0471	metal ion transport
CFN12_RS14870	COG2962	Rard protein
CFN12_RS14880	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
CFN12_RS14895	COG1136	(ABC) transporter
CFN12_RS14900	COG0577	efflux transmembrane transporter activity
CFN12_RS14930	COG1278	Cold shock
CFN12_RS14950	COG1475	DNA binding