locus-tag	class	description
X998_RS00010	COG1473	amidohydrolase
X998_RS00015	COG1028	Short-chain dehydrogenase reductase Sdr
X998_RS00035	COG1737	Transcriptional regulator
X998_RS00040	COG1263	PTS System
X998_RS00040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
X998_RS00050	COG0385	Bile acid
X998_RS00055	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
X998_RS00075	COG1113	amino acid transport
X998_RS00150	COG3942	CHAP domain
X998_RS00165	COG1757	Na H antiporter
X998_RS00175	COG3942	CHAP domain
X998_RS00240	COG4413	Urea transporter
X998_RS00245	COG1960	acyl-CoA dehydrogenase activity
X998_RS00260	COG1268	BioY protein
X998_RS00275	COG0725	ABC transporter, periplasmic molybdate-binding protein
X998_RS00280	COG4149	molybdate abc transporter
X998_RS00285	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
X998_RS00290	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
X998_RS00310	COG1763	Mo-molybdopterin cofactor biosynthetic process
X998_RS00385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
X998_RS00430	COG2252	PERMEase
X998_RS00545	COG0201	protein transport
X998_RS00630	COG0542	response to heat
X998_RS00650	COG0028	Belongs to the TPP enzyme family
X998_RS00655	COG3527	Alpha-acetolactate decarboxylase
X998_RS00675	COG5492	domain, Protein
X998_RS00685	COG0789	Transcriptional regulator
X998_RS00690	COG0656	L-ascorbic acid biosynthetic process
X998_RS00760	COG2130	NADP-dependent
X998_RS00770	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
X998_RS00800	COG2814	Major facilitator Superfamily
X998_RS00805	COG4264	IucA IucC family
X998_RS00810	COG3457	Alanine racemase
X998_RS00820	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
X998_RS00825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
X998_RS00830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
X998_RS00835	COG3314	Sporulation integral membrane protein YlbJ
X998_RS00845	COG1988	membrane-bound metal-dependent
X998_RS00855	COG1272	protein, Hemolysin III
X998_RS00870	COG2814	Major facilitator Superfamily
X998_RS00875	COG0489	protein tyrosine kinase activity
X998_RS00950	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
X998_RS00980	COG3711	transcriptional antiterminator
X998_RS00995	COG1119	ATPase activity
X998_RS01000	COG0561	phosphatase activity
X998_RS01035	COG0640	Transcriptional regulator
X998_RS01040	COG0702	epimerase
X998_RS01045	COG1482	cell wall glycoprotein biosynthetic process
X998_RS01065	COG0783	Belongs to the Dps family
X998_RS01070	COG0813	purine-nucleoside phosphorylase activity
X998_RS01120	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
X998_RS01160	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
X998_RS01185	COG2890	protein-(glutamine-N5) methyltransferase activity
X998_RS01190	COG0009	L-threonylcarbamoyladenylate synthase
X998_RS01215	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
X998_RS01290	COG0629	single-stranded DNA binding
X998_RS01340	COG1418	mRNA catabolic process
X998_RS01350	COG1937	Protein conserved in bacteria
X998_RS01365	COG0772	Belongs to the SEDS family
X998_RS01375	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
X998_RS01385	COG0745	RESPONSE REGULATOR receiver
X998_RS01390	COG2205	protein histidine kinase activity
X998_RS01420	COG3428	Bacterial PH domain
X998_RS01455	COG2208	phosphoserine phosphatase activity
X998_RS01460	COG1366	Belongs to the anti-sigma-factor antagonist family
X998_RS01470	COG1191	sigma factor activity
X998_RS01475	COG2183	response to ionizing radiation
X998_RS01550	COG0028	Belongs to the TPP enzyme family
X998_RS01565	COG0802	atpase or kinase
X998_RS01570	COG1214	PFAM Peptidase M22, glycoprotease
X998_RS01575	COG0456	acetyltransferase
X998_RS01585	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
X998_RS01595	COG0488	(ABC) transporter
X998_RS01605	COG2391	methyltransferase activity
X998_RS01610	COG0425	Belongs to the sulfur carrier protein TusA family
X998_RS01615	COG0004	ammonium transporteR
X998_RS01620	COG1609	Transcriptional regulator
X998_RS01625	COG1621	beta-fructofuranosidase activity
X998_RS01630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
X998_RS01705	COG5484	DNA packaging
X998_RS01705	COG3728	DNA packaging
X998_RS01725	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
X998_RS01730	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
X998_RS01735	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
X998_RS01785	COG1725	Transcriptional regulator
X998_RS01800	COG1131	(ABC) transporter
X998_RS01855	COG1012	belongs to the aldehyde dehydrogenase family
X998_RS01870	COG1335	isochorismatase
X998_RS01880	COG0471	metal ion transport
X998_RS01890	COG0077	Prephenate dehydratase
X998_RS01900	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
X998_RS01940	COG4496	protein, YerC YecD
X998_RS01950	COG0210	DNA helicase
X998_RS01960	COG4851	CamS sex pheromone cAM373 precursor
X998_RS02090	COG2197	response regulator
X998_RS02095	COG1295	ribonuclease BN
X998_RS02115	COG2309	aminopeptidase activity
X998_RS02120	COG1607	acyl-coa hydrolase
X998_RS02125	COG0535	radical SAM domain protein
X998_RS02155	COG1388	LysM domain
X998_RS02155	COG1134	teichoic acid transport
X998_RS02170	COG1988	membrane-bound metal-dependent
X998_RS02195	COG4129	membrane
X998_RS02205	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
X998_RS02210	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
X998_RS02385	COG0765	amino acid transport
X998_RS02390	COG1126	abc transporter atp-binding protein
X998_RS02395	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
X998_RS02435	COG0564	pseudouridine synthase activity
X998_RS02440	COG4585	Histidine kinase
X998_RS02440	COG2203	Gaf domain
X998_RS02445	COG2197	response regulator
X998_RS02475	COG0420	3'-5' exonuclease activity
X998_RS02510	COG0537	adenosine 5'-monophosphoramidase activity
X998_RS02515	COG1131	(ABC) transporter
X998_RS02545	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
X998_RS02675	COG1131	(ABC) transporter
X998_RS02860	COG1506	peptidase
X998_RS02885	COG0656	L-ascorbic acid biosynthetic process
X998_RS02910	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
X998_RS02940	COG5632	N-Acetylmuramoyl-L-alanine amidase
X998_RS02940	COG4193	domain, Protein
X998_RS02940	COG3266	domain, Protein
X998_RS02965	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
X998_RS02965	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
X998_RS03000	COG2267	carboxylic ester hydrolase activity
X998_RS03015	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
X998_RS03020	COG1242	4 iron, 4 sulfur cluster binding
X998_RS03025	COG2814	Major facilitator Superfamily
X998_RS03045	COG2081	HI0933 family
X998_RS03050	COG2244	polysaccharide biosynthetic process
X998_RS03055	COG1187	pseudouridine synthase activity
X998_RS03080	COG0510	thiamine kinase activity
X998_RS03090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
X998_RS03100	COG1363	Peptidase, m42
X998_RS03105	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
X998_RS03115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
X998_RS03120	COG1674	ftsk spoiiie
X998_RS03145	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
X998_RS03145	COG1605	Chorismate mutase
X998_RS03165	COG0454	-acetyltransferase
X998_RS03170	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
X998_RS03205	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
X998_RS03210	COG0204	Acyl-transferase
X998_RS03215	COG1263	PTS System
X998_RS03215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
X998_RS03230	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
X998_RS03235	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
X998_RS03240	COG1764	response to oxidative stress
X998_RS03245	COG0584	glycerophosphoryl diester phosphodiesterase
X998_RS03265	COG1956	GAF domain-containing protein
X998_RS03280	COG1104	cysteine desulfurase activity
X998_RS03300	COG0827	DNA restriction-modification system
X998_RS03340	COG4109	DRTGG domain
X998_RS03350	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
X998_RS03360	COG0281	malic enzyme
X998_RS03390	COG1113	amino acid transport
X998_RS03395	COG0372	Belongs to the citrate synthase family
X998_RS03410	COG0745	RESPONSE REGULATOR receiver
X998_RS03415	COG5002	protein histidine kinase activity
X998_RS03425	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
X998_RS03425	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
X998_RS03455	COG1484	DNA-dependent DNA replication
X998_RS03470	COG0833	amino acid
X998_RS03495	COG4112	unkown
X998_RS03530	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
X998_RS03565	COG2818	Glycosylase
X998_RS03575	COG0285	dihydrofolate synthase activity
X998_RS03585	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
X998_RS03630	COG2868	ribosomal protein
X998_RS03670	COG1862	Preprotein translocase
X998_RS03675	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
X998_RS03675	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
X998_RS03680	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
X998_RS03680	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
X998_RS03725	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
X998_RS03730	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
X998_RS03735	COG1959	2 iron, 2 sulfur cluster binding
X998_RS03750	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
X998_RS03755	COG1104	cysteine desulfurase activity
X998_RS03770	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
X998_RS03800	COG0826	peptidase U32
X998_RS03805	COG0826	peptidase U32
X998_RS03820	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
X998_RS03825	COG1984	allophanate hydrolase subunit 2
X998_RS03830	COG0511	ligase activity, forming carbon-carbon bonds
X998_RS03835	COG0439	Biotin carboxylase
X998_RS03845	COG1914	H( )-stimulated, divalent metal cation uptake system
X998_RS03850	COG3177	Filamentation induced by cAMP protein fic
X998_RS03870	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
X998_RS03875	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
X998_RS03885	COG1534	Rna-binding protein
X998_RS03895	COG1713	HD superfamily hydrolase involved in NAD metabolism
X998_RS03900	COG0799	negative regulation of ribosome biogenesis
X998_RS03905	COG2226	methyltransferase
X998_RS03915	COG2131	deaminase
X998_RS03920	COG2333	competence protein COMEC
X998_RS03920	COG0658	competence protein
X998_RS03925	COG1466	dna polymerase III delta subunit
X998_RS03945	COG0635	Involved in the biosynthesis of porphyrin-containing compound
X998_RS03975	COG1385	rRNA (uridine-N3-)-methyltransferase activity
X998_RS03980	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
X998_RS03990	COG1030	water channel activity
X998_RS04005	COG1702	phosphate starvation-inducible protein PhoH
X998_RS04020	COG0295	cytidine deaminase activity
X998_RS04040	COG0517	IMP dehydrogenase activity
X998_RS04060	COG2384	SAM-dependent methyltransferase
X998_RS04070	COG0513	Belongs to the DEAD box helicase family
X998_RS04080	COG1121	(ABC) transporter
X998_RS04085	COG1108	ABC-type Mn2 Zn2 transport systems permease components
X998_RS04100	COG0768	penicillin binding
X998_RS04110	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
X998_RS04120	COG4483	Protein conserved in bacteria
X998_RS04125	COG1940	carbohydrate kinase activity
X998_RS04130	COG0011	TIGRFAM Protein of
X998_RS04135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
X998_RS04140	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
X998_RS04145	COG1459	type II secretion system
X998_RS04150	COG4537	Required for transformation and DNA binding
X998_RS04195	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
X998_RS04200	COG0095	Lipoate-protein ligase
X998_RS04215	COG0006	proline dipeptidase activity
X998_RS04240	COG2946	Replication initiation factor
X998_RS04260	COG0433	COG0433 Predicted ATPase
X998_RS04265	COG1674	ftsk spoiiie
X998_RS04295	COG0511	ligase activity, forming carbon-carbon bonds
X998_RS04300	COG0439	Biotin carboxylase
X998_RS04305	COG1302	Protein conserved in bacteria
X998_RS04335	COG0497	DNA recombination
X998_RS04340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
X998_RS04345	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
X998_RS04350	COG0022	dehydrogenase e1 component
X998_RS04355	COG0508	dehydrogenase complex catalyzes the overall conversion of
X998_RS04365	COG4129	membrane
X998_RS04375	COG2195	Cleaves the N-terminal amino acid of tripeptides
X998_RS04395	COG1609	Transcriptional regulator
X998_RS04400	COG0366	Alpha amylase catalytic
X998_RS04410	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
X998_RS04425	COG4221	oxidoreductase activity
X998_RS04435	COG0667	Aldo Keto reductase
X998_RS04440	COG0494	nUDIX hydrolase
X998_RS04445	COG0735	belongs to the Fur family
X998_RS04470	COG1187	pseudouridine synthase activity
X998_RS04475	COG0745	RESPONSE REGULATOR receiver
X998_RS04480	COG5002	protein histidine kinase activity
X998_RS04525	COG1141	Ferredoxin
X998_RS04535	COG0514	ATP-dependent DNA helicase (RecQ)
X998_RS04550	COG0492	ferredoxin-NADP+ reductase activity
X998_RS04615	COG0142	geranyltranstransferase activity
X998_RS04655	COG4347	Protein of unknown function (DUF1405)
X998_RS04660	COG2738	Putative neutral zinc metallopeptidase
X998_RS04665	COG1694	Mazg nucleotide pyrophosphohydrolase
X998_RS04670	COG0438	transferase activity, transferring glycosyl groups
X998_RS04695	COG3935	DnaD domain protein
X998_RS04700	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
X998_RS04710	COG4499	WXG100 protein secretion system (Wss), protein YukC
X998_RS04710	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
X998_RS04750	COG0116	Belongs to the methyltransferase superfamily
X998_RS04765	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
X998_RS04770	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
X998_RS04785	COG0531	amino acid
X998_RS04810	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
X998_RS04825	COG1413	lyase activity
X998_RS04885	COG0671	phosphoesterase, PA-phosphatase related
X998_RS04930	COG0714	Associated with various cellular activities
X998_RS04935	COG4548	von Willebrand factor, type A
X998_RS05015	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
X998_RS05020	COG0527	aspartate kinase activity
X998_RS05025	COG0488	(ABC) transporter
X998_RS05045	COG0573	inorganic phosphate transmembrane transporter activity
X998_RS05050	COG0581	inorganic phosphate transmembrane transporter activity
X998_RS05060	COG0704	Plays a role in the regulation of phosphate uptake
X998_RS05105	COG0561	phosphatase activity
X998_RS05145	COG0512	Glutamine amidotransferase of anthranilate synthase
X998_RS05150	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
X998_RS05155	COG1363	Peptidase, m42
X998_RS05165	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
X998_RS05185	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
X998_RS05185	COG0392	lysyltransferase activity
X998_RS05190	COG0628	permease
X998_RS05205	COG1115	amino acid carrier protein
X998_RS05215	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
X998_RS05245	COG0824	Thioesterase
X998_RS05260	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
X998_RS05280	COG4846	Membrane protein involved in cytochrome C biogenesis
X998_RS05315	COG2340	Cysteine-rich secretory protein family
X998_RS05345	COG0833	amino acid
X998_RS05370	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
X998_RS05375	COG0460	homoserine dehydrogenase
X998_RS05380	COG0527	aspartate kinase activity
X998_RS05395	COG1525	nuclease
X998_RS05405	COG2197	response regulator
X998_RS05420	COG1131	(ABC) transporter
X998_RS05540	COG0789	Transcriptional regulator
X998_RS05545	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
X998_RS05550	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
X998_RS05560	COG1923	regulation of RNA biosynthetic process
X998_RS05585	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
X998_RS05590	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
X998_RS05625	COG1013	pyruvate-flavodoxin oxidoreductase activity
X998_RS05630	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
X998_RS05630	COG0674	pyruvate-flavodoxin oxidoreductase activity
X998_RS05635	COG1692	metallophosphoesterase
X998_RS05655	COG1058	Belongs to the CinA family
X998_RS05655	COG1546	Belongs to the CinA family
X998_RS05675	COG0300	oxidoreductase activity
X998_RS05680	COG0612	Peptidase, M16
X998_RS05685	COG0612	Peptidase, M16
X998_RS05690	COG2188	Transcriptional regulator
X998_RS05720	COG0196	riboflavin kinase activity
X998_RS05745	COG2740	Nucleic-acid-binding protein implicated in transcription termination
X998_RS05750	COG0195	Participates in both transcription termination and antitermination
X998_RS05850	COG0758	DNA mediated transformation
X998_RS05910	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
X998_RS05920	COG0552	protein localization to endoplasmic reticulum
X998_RS05925	COG1196	nuclear chromosome segregation
X998_RS05965	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
X998_RS05975	COG1302	Protein conserved in bacteria
X998_RS05990	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
X998_RS06005	COG0631	protein serine/threonine phosphatase activity
X998_RS06015	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
X998_RS06015	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
X998_RS06030	COG2314	TM2 domain
X998_RS06040	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
X998_RS06045	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
X998_RS06060	COG1293	RNA-binding protein homologous to eukaryotic snRNP
X998_RS06105	COG2233	PERMEase
X998_RS06115	COG0564	pseudouridine synthase activity
X998_RS06135	COG2514	catechol 2,3-dioxygenase activity
X998_RS06145	COG3599	regulation of cell shape
X998_RS06150	COG2302	S4 RNA-binding domain
X998_RS06155	COG0762	integral membrane protein
X998_RS06165	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
X998_RS06180	COG0849	cell division
X998_RS06185	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
X998_RS06200	COG0768	penicillin binding
X998_RS06205	COG4839	cell division protein FtsL
X998_RS06230	COG1011	Hydrolase
X998_RS06265	COG1288	antiporter activity
X998_RS06380	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
X998_RS06385	COG1053	succinate dehydrogenase
X998_RS06390	COG2009	succinate dehydrogenase
X998_RS06415	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
X998_RS06415	COG1796	DNA polymerase
X998_RS06450	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
X998_RS06465	COG4509	Sortase family
X998_RS06525	COG0742	ribosomal rna small subunit methyltransferase
X998_RS06545	COG3679	Belongs to the UPF0342 family
X998_RS06580	COG0772	Belongs to the SEDS family
X998_RS06590	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
X998_RS06600	COG1217	gtp-binding protein TYPA
X998_RS06610	COG0483	inositol monophosphate 1-phosphatase activity
X998_RS06635	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
X998_RS06640	COG1177	transmembrane transport
X998_RS06645	COG1176	ABC-type spermidine putrescine transport system, permease component I
X998_RS06710	COG0569	domain protein
X998_RS06715	COG1294	oxidase, subunit
X998_RS06720	COG1271	oxidase subunit
X998_RS06745	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
X998_RS06770	COG4721	ABC-type cobalt transport system, permease component
X998_RS06775	COG4172	Belongs to the ABC transporter superfamily
X998_RS06780	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
X998_RS06790	COG0138	bifunctional purine biosynthesis protein purh
X998_RS06820	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
X998_RS06835	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
X998_RS06875	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
X998_RS06880	COG1316	TRANSCRIPTIONal
X998_RS06910	COG3594	Acyltransferase
X998_RS06915	COG0436	Aminotransferase
X998_RS06940	COG2267	carboxylic ester hydrolase activity
X998_RS06950	COG1169	isochorismate synthase
X998_RS06960	COG1575	Belongs to the MenA family. Type 1 subfamily
X998_RS06965	COG0456	acetyltransferase
X998_RS06970	COG2314	TM2 domain
X998_RS06980	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
X998_RS07040	COG4873	Protein conserved in bacteria
X998_RS07055	COG4903	ComK protein
X998_RS07070	COG0737	Belongs to the 5'-nucleotidase family
X998_RS07075	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
X998_RS07085	COG0861	Integral membrane protein TerC family
X998_RS07125	COG1115	amino acid carrier protein
X998_RS07130	COG0628	permease
X998_RS07140	COG0475	glutathione-regulated potassium exporter activity
X998_RS07140	COG0569	domain protein
X998_RS07145	COG2239	Acts as a magnesium transporter
X998_RS07150	COG0564	pseudouridine synthase activity
X998_RS07160	COG2357	RelA SpoT domain protein
X998_RS07175	COG2346	COG2346, Truncated hemoglobins
X998_RS07185	COG1164	Oligoendopeptidase f
X998_RS07210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
X998_RS07215	COG0601	transmembrane transport
X998_RS07220	COG4608	Belongs to the ABC transporter superfamily
X998_RS07225	COG0444	Belongs to the ABC transporter superfamily
X998_RS07230	COG0747	negative chemotaxis
X998_RS07235	COG4166	transmembrane transport
X998_RS07240	COG4608	Belongs to the ABC transporter superfamily
X998_RS07245	COG0444	Belongs to the ABC transporter superfamily
X998_RS07250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
X998_RS07255	COG0601	transmembrane transport
X998_RS07285	COG1881	PFAM PEBP family protein
X998_RS07300	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
X998_RS07325	COG0561	phosphatase activity
X998_RS07365	COG0398	Pfam SNARE associated Golgi protein
X998_RS07385	COG0584	glycerophosphoryl diester phosphodiesterase
X998_RS07405	COG1902	pentaerythritol trinitrate reductase activity
X998_RS07410	COG1098	S1 RNA binding domain
X998_RS07465	COG2050	protein possibly involved in aromatic compounds catabolism
X998_RS07470	COG2056	Na+-H+ antiporter family
X998_RS07475	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
X998_RS07485	COG0316	Belongs to the HesB IscA family
X998_RS07495	COG1252	NADH dehydrogenase
X998_RS07500	COG4837	Protein of unknown function (DUF1462)
X998_RS07505	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
X998_RS07510	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
X998_RS07520	COG1696	Membrane protein involved in D-alanine export
X998_RS07550	COG2445	Protein of unknown function DUF86
X998_RS07560	COG4470	Protein conserved in bacteria
X998_RS07575	COG0730	response to heat
X998_RS07580	COG1801	Protein of unknown function DUF72
X998_RS07595	COG1253	flavin adenine dinucleotide binding
X998_RS07620	COG0822	iron-sulfur transferase activity
X998_RS07630	COG0719	Fe-S assembly protein
X998_RS07635	COG0396	ATPase activity
X998_RS07675	COG3728	DNA packaging
X998_RS07675	COG5484	DNA packaging
X998_RS07780	COG0582	viral genome integration into host DNA
X998_RS07785	COG1464	Belongs to the NlpA lipoprotein family
X998_RS07790	COG2011	ABC-type metal ion transport system permease component
X998_RS07805	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
X998_RS07815	COG3878	Protein conserved in bacteria
X998_RS07830	COG1393	Belongs to the ArsC family
X998_RS07835	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
X998_RS07860	COG1279	arginine transmembrane transporter activity
X998_RS07865	COG0406	alpha-ribazole phosphatase activity
X998_RS07905	COG1278	Cold shock
X998_RS07980	COG0557	exoribonuclease II activity
X998_RS07985	COG1647	Serine aminopeptidase, S33
X998_RS07990	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
X998_RS08055	COG0391	Required for morphogenesis under gluconeogenic growth conditions
X998_RS08115	COG1388	LysM domain
X998_RS08115	COG3942	CHAP domain
X998_RS08145	COG1040	competence protein
X998_RS08150	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
X998_RS08160	COG1739	Uncharacterized protein family UPF0029
X998_RS08165	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
X998_RS08220	COG4607	ABC-type enterochelin transport system periplasmic component
X998_RS08225	COG4604	ABC transporter, ATP-binding protein
X998_RS08230	COG4605	iron ion homeostasis
X998_RS08235	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
X998_RS08250	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
X998_RS08255	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
X998_RS08285	COG3104	oligopeptide transport
X998_RS08315	COG1174	glycine betaine transport
X998_RS08320	COG1125	glycine betaine transport
X998_RS08320	COG0517	IMP dehydrogenase activity
X998_RS08325	COG0514	ATP-dependent DNA helicase (RecQ)
X998_RS08330	COG0488	(ABC) transporter
X998_RS08360	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
X998_RS08365	COG0512	Glutamine amidotransferase of anthranilate synthase
X998_RS08365	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
X998_RS08375	COG0720	synthase
X998_RS08410	COG0463	Glycosyl transferase, family 2
X998_RS08415	COG0656	L-ascorbic acid biosynthetic process
X998_RS08420	COG1253	flavin adenine dinucleotide binding
X998_RS08425	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
X998_RS08435	COG1105	Belongs to the carbohydrate kinase PfkB family
X998_RS08440	COG1349	DNA-binding transcription factor activity
X998_RS08445	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
X998_RS08475	COG0415	Belongs to the DNA photolyase family
X998_RS08480	COG0471	metal ion transport
X998_RS08490	COG4989	oxidoreductase activity
X998_RS08495	COG0523	cobalamin synthesis protein
X998_RS08505	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
X998_RS08510	COG4988	ABC transporter
X998_RS08530	COG1611	Belongs to the LOG family
X998_RS08560	COG2839	Protein conserved in bacteria
X998_RS08565	COG2814	Major facilitator Superfamily
X998_RS08575	COG0583	DNA-binding transcription factor activity
X998_RS08605	COG1917	Cupin 2, conserved barrel domain protein
X998_RS08605	COG4977	sequence-specific DNA binding
X998_RS08615	COG1388	LysM domain
X998_RS08615	COG3942	CHAP domain
X998_RS08620	COG0306	phosphate transporter
X998_RS08625	COG1392	Phosphate transport regulator
X998_RS08630	COG0577	efflux transmembrane transporter activity
X998_RS08635	COG1136	(ABC) transporter
X998_RS08650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
X998_RS08675	COG3949	Membrane
X998_RS08685	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
X998_RS08695	COG2376	Dihydroxyacetone kinase
X998_RS08700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
X998_RS08705	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
X998_RS08710	COG1120	ATPase activity
X998_RS08715	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
X998_RS08725	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
X998_RS08730	COG1132	(ABC) transporter
X998_RS08735	COG1686	Belongs to the peptidase S11 family
X998_RS08740	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
X998_RS08745	COG1216	Glycosyl transferase, family 2
X998_RS08750	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
X998_RS08755	COG1682	transport, permease protein
X998_RS08765	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
X998_RS08775	COG1321	iron dependent repressor
X998_RS08780	COG1121	(ABC) transporter
X998_RS08785	COG1108	ABC-type Mn2 Zn2 transport systems permease components
X998_RS08790	COG0803	Belongs to the bacterial solute-binding protein 9 family
X998_RS08835	COG4974	Belongs to the 'phage' integrase family
X998_RS08885	COG4139	cobalamin transport
X998_RS08890	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
X998_RS08930	COG1078	dGTPase activity
X998_RS08940	COG0655	NAD(P)H dehydrogenase (quinone) activity
X998_RS08945	COG0667	Aldo Keto reductase
X998_RS09035	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
X998_RS09055	COG0083	homoserine kinase activity
X998_RS09060	COG0095	Lipoate-protein ligase
X998_RS09160	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
X998_RS09175	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
X998_RS09220	COG0561	phosphatase activity
X998_RS09230	COG1428	Deoxynucleoside kinase
X998_RS09235	COG1428	Deoxynucleoside kinase
X998_RS09240	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
X998_RS09275	COG1473	amidohydrolase
X998_RS09315	COG2813	Specifically methylates the guanine in position
X998_RS09375	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
X998_RS09400	COG4956	integral membrane protein (PIN domain superfamily)
X998_RS09405	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
X998_RS09420	COG3880	PFAM UvrB UvrC protein
X998_RS09430	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
X998_RS09445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
X998_RS09505	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
X998_RS09530	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
X998_RS09545	COG1098	S1 RNA binding domain
X998_RS09555	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
X998_RS09560	COG3956	TIGRFAM MazG family protein
X998_RS09565	COG2244	polysaccharide biosynthetic process
X998_RS09610	COG0251	oxidation-reduction process
X998_RS09615	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
X998_RS09625	COG4466	Protein conserved in bacteria
X998_RS09635	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
X998_RS09640	COG0084	hydrolase, TatD family'
X998_RS09650	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
X998_RS09660	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
X998_RS09670	COG1774	PSP1 C-terminal conserved region
X998_RS09675	COG0470	DNA polymerase III
X998_RS09680	COG3870	Protein conserved in bacteria
X998_RS09690	COG1982	Orn Lys Arg decarboxylase major
X998_RS09730	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
X998_RS09750	COG2188	Transcriptional regulator
X998_RS09755	COG0366	Alpha amylase catalytic
X998_RS09760	COG1263	PTS System
X998_RS09760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
X998_RS09770	COG0493	'glutamate synthase
X998_RS09775	COG0069	glutamate synthase activity
X998_RS09775	COG0067	glutamate synthase
X998_RS09775	COG0070	glutamate synthase
X998_RS09780	COG0583	DNA-binding transcription factor activity
X998_RS09815	COG1464	Belongs to the NlpA lipoprotein family
X998_RS09820	COG2011	ABC-type metal ion transport system permease component
X998_RS09830	COG0626	cystathionine gamma-synthase activity
X998_RS09835	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
X998_RS09840	COG0733	neurotransmitter:sodium symporter activity
X998_RS09850	COG1647	Serine aminopeptidase, S33
X998_RS09865	COG5609	conserved protein (DUF2294)
X998_RS09875	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
X998_RS09900	COG0523	cobalamin synthesis protein
X998_RS10025	COG3759	membrane
X998_RS10065	COG2233	PERMEase
X998_RS10100	COG1823	symporter activity
X998_RS10115	COG3634	alkyl hydroperoxide reductase activity
X998_RS10175	COG4974	Belongs to the 'phage' integrase family
X998_RS10210	COG0012	GTP binding
X998_RS10215	COG4481	Protein conserved in bacteria
X998_RS10220	COG0668	transmembrane transport
X998_RS10225	COG1475	DNA binding
X998_RS10235	COG0626	cystathionine gamma-synthase activity
X998_RS10240	COG0626	cystathionine gamma-synthase activity
X998_RS10245	COG0646	methionine synthase
X998_RS10245	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
X998_RS10275	COG1131	(ABC) transporter
X998_RS10285	COG1476	TRANSCRIPTIONal
X998_RS10295	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
X998_RS10300	COG0805	protein transport
X998_RS10305	COG0672	)-iron permease
X998_RS10315	COG2822	iron ion transport
X998_RS10320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
X998_RS10335	COG0431	NADPH-dependent FMN reductase
X998_RS10340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
X998_RS10350	COG2271	Major facilitator Superfamily
X998_RS10375	COG3711	transcriptional antiterminator
X998_RS10380	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
X998_RS10390	COG3037	sugar-specific permease SgaT UlaA
X998_RS10420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
X998_RS10450	COG0860	N-Acetylmuramoyl-L-alanine amidase
X998_RS10450	COG1388	LysM domain
X998_RS10500	COG3953	SLT domain
X998_RS10500	COG5280	Phage tail tape measure protein TP901
X998_RS10610	COG0756	dUTP diphosphatase activity
X998_RS10680	COG0305	Participates in initiation and elongation during chromosome replication
X998_RS10800	COG0582	viral genome integration into host DNA
X998_RS10810	COG3314	Sporulation integral membrane protein YlbJ
X998_RS10835	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
X998_RS10840	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
X998_RS10870	COG0577	efflux transmembrane transporter activity
X998_RS10880	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
X998_RS10890	COG1114	Component of the transport system for branched-chain amino acids
X998_RS11050	COG1388	LysM domain
X998_RS11050	COG3942	CHAP domain
X998_RS11080	COG1131	(ABC) transporter
X998_RS11140	COG2226	methyltransferase
X998_RS11150	COG2723	6-phospho-beta-galactosidase activity
X998_RS11155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
X998_RS11155	COG2190	(PTS) system
X998_RS11155	COG1263	PTS System
X998_RS11165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
X998_RS11200	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
X998_RS11205	COG1063	alcohol dehydrogenase
X998_RS11215	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
X998_RS11220	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
X998_RS11225	COG1063	alcohol dehydrogenase
X998_RS11235	COG1063	alcohol dehydrogenase
X998_RS11245	COG1063	alcohol dehydrogenase
X998_RS11250	COG3775	system Galactitol-specific IIC component
X998_RS11255	COG3414	Phosphotransferase system galactitol-specific IIB component
X998_RS11275	COG1957	nucleoside hydrolase
X998_RS11280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
X998_RS11280	COG2190	(PTS) system
X998_RS11280	COG1263	PTS System
X998_RS11315	COG3189	MarR family transcriptional regulator
X998_RS11320	COG0747	negative chemotaxis
X998_RS11335	COG0318	PFAM AMP-dependent synthetase and ligase
X998_RS11340	COG1960	acyl-CoA dehydrogenase activity
X998_RS11350	COG0183	Belongs to the thiolase family
X998_RS11410	COG1755	Isoprenylcysteine carboxyl methyltransferase
X998_RS11420	COG0673	inositol 2-dehydrogenase activity
X998_RS11425	COG0673	inositol 2-dehydrogenase activity
X998_RS11430	COG3833	ABC-type maltose transport systems, permease component
X998_RS11435	COG1175	transmembrane transport
X998_RS11445	COG3842	ATPase activity
X998_RS11465	COG0405	Gamma-glutamyltransferase
X998_RS11475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
X998_RS11480	COG0601	transmembrane transport
X998_RS11515	COG1737	Transcriptional regulator
X998_RS11545	COG3961	Belongs to the TPP enzyme family
X998_RS11550	COG1335	isochorismatase
X998_RS11555	COG1114	Component of the transport system for branched-chain amino acids
X998_RS11605	COG5609	conserved protein (DUF2294)
X998_RS11610	COG1960	acyl-CoA dehydrogenase activity
X998_RS11615	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
X998_RS11650	COG2832	Protein of unknown function (DUF454)
X998_RS11660	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
X998_RS11665	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
X998_RS11675	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
X998_RS11705	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
X998_RS11715	COG1086	Polysaccharide biosynthesis protein
X998_RS11740	COG1454	alcohol dehydrogenase
X998_RS11740	COG1012	belongs to the aldehyde dehydrogenase family
X998_RS11765	COG0737	Belongs to the 5'-nucleotidase family
X998_RS11785	COG3639	organic phosphonate transmembrane transporter activity
X998_RS11805	COG2814	Major facilitator Superfamily
X998_RS11810	COG0813	purine-nucleoside phosphorylase activity
X998_RS11845	COG0438	transferase activity, transferring glycosyl groups
X998_RS11850	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
X998_RS11855	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
X998_RS11885	COG1475	DNA binding
X998_RS11890	COG0019	diaminopimelate decarboxylase activity
X998_RS11900	COG4264	IucA IucC family
X998_RS11905	COG4264	IucA IucC family
X998_RS11910	COG2814	Major facilitator Superfamily
X998_RS11915	COG4264	IucA IucC family
X998_RS11920	COG2423	ornithine cyclodeaminase activity
X998_RS11930	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
X998_RS11935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
X998_RS11940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
X998_RS11960	COG1620	l-lactate permease
X998_RS11975	COG0697	spore germination
X998_RS11980	COG4716	Myosin-crossreactive antigen
X998_RS11985	COG1283	sodium-dependent phosphate transmembrane transporter activity
X998_RS11995	COG1473	amidohydrolase
X998_RS12025	COG0823	Involved in the tonB-independent uptake of proteins
X998_RS12045	COG0583	DNA-binding transcription factor activity
X998_RS12060	COG0655	NAD(P)H dehydrogenase (quinone) activity
X998_RS12100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
X998_RS12105	COG2210	Belongs to the sulfur carrier protein TusA family
X998_RS12110	COG1937	Protein conserved in bacteria
X998_RS12115	COG0730	response to heat
X998_RS12185	COG0730	response to heat
X998_RS12190	COG1937	Protein conserved in bacteria
X998_RS12195	COG2210	Belongs to the sulfur carrier protein TusA family
X998_RS12200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
X998_RS12270	COG2030	dehydratase
X998_RS12275	COG0584	glycerophosphoryl diester phosphodiesterase
X998_RS12285	COG3425	synthase
X998_RS12310	COG0737	Belongs to the 5'-nucleotidase family
X998_RS12315	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
X998_RS12325	COG4863	YycH protein
X998_RS12360	COG0305	Participates in initiation and elongation during chromosome replication
X998_RS12370	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
X998_RS12380	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
X998_RS12410	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
X998_RS12430	COG2501	S4 domain
X998_RS12470	COG1475	DNA binding
X998_RS12495	COG1278	Cold shock
X998_RS12525	COG0577	efflux transmembrane transporter activity
X998_RS12530	COG1136	(ABC) transporter
X998_RS12545	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
X998_RS12555	COG2962	Rard protein
X998_RS12560	COG0471	metal ion transport
X998_RS12645	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
X998_RS12680	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
X998_RS12740	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
X998_RS12760	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
X998_RS12780	COG1073	alpha beta
X998_RS12795	COG0438	transferase activity, transferring glycosyl groups
X998_RS12810	COG3433	isochorismatase activity
X998_RS12810	COG1535	isochorismatase
X998_RS12815	COG3942	CHAP domain
X998_RS12815	COG1705	Flagellar rod assembly protein muramidase FlgJ
X998_RS12825	COG1482	cell wall glycoprotein biosynthetic process
X998_RS12830	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
X998_RS12830	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
X998_RS12830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
X998_RS12835	COG3711	transcriptional antiterminator
X998_RS12835	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
X998_RS12855	COG1438	arginine binding
X998_RS12900	COG1846	Transcriptional regulator
X998_RS12910	COG1785	Belongs to the alkaline phosphatase family
X998_RS12920	COG0745	RESPONSE REGULATOR receiver
X998_RS12925	COG2205	protein histidine kinase activity
X998_RS12930	COG1136	(ABC) transporter
X998_RS12955	COG0386	Belongs to the glutathione peroxidase family
X998_RS12965	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
X998_RS12980	COG2851	Citrate transporter
X998_RS13005	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
X998_RS13015	COG1510	regulation of RNA biosynthetic process
X998_RS13025	COG1012	belongs to the aldehyde dehydrogenase family
X998_RS13045	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
X998_RS13075	COG0531	amino acid
X998_RS13090	COG3527	Alpha-acetolactate decarboxylase
X998_RS13095	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
X998_RS13145	COG0167	dihydroorotate dehydrogenase activity
X998_RS13150	COG3001	Fructosamine kinase
X998_RS13190	COG0596	Alpha beta hydrolase
X998_RS13260	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
X998_RS13260	COG2755	lipolytic protein G-D-S-L family
X998_RS13265	COG3942	CHAP domain
X998_RS13295	COG0436	Aminotransferase
X998_RS13340	COG2409	Drug exporters of the RND superfamily
X998_RS13360	COG0542	response to heat
X998_RS13365	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
X998_RS13370	COG3425	synthase
X998_RS13395	COG3942	CHAP domain
X998_RS13405	COG0583	DNA-binding transcription factor activity
X998_RS13420	COG0028	Belongs to the TPP enzyme family
X998_RS13440	COG0657	acetylesterase activity
X998_RS13445	COG0697	spore germination
X998_RS13460	COG1760	l-serine dehydratase
X998_RS13465	COG1760	l-serine dehydratase
X998_RS13485	COG3764	Sortase (surface protein transpeptidase)
X998_RS13495	COG1131	(ABC) transporter
X998_RS13500	COG0561	phosphatase activity
X998_RS13515	COG2514	catechol 2,3-dioxygenase activity
X998_RS13525	COG1846	Transcriptional regulator
X998_RS13530	COG0346	lactoylglutathione lyase activity
X998_RS13535	COG0400	carboxylic ester hydrolase activity
X998_RS13555	COG1131	(ABC) transporter
X998_RS13570	COG1846	Transcriptional regulator
X998_RS13575	COG2814	Major facilitator Superfamily
X998_RS13585	COG0586	Pfam SNARE associated Golgi protein
X998_RS13590	COG2271	Major facilitator Superfamily
X998_RS13600	COG4876	unkown
X998_RS13605	COG2357	RelA SpoT domain protein
X998_RS13610	COG0789	Transcriptional regulator
X998_RS13615	COG1802	Transcriptional regulator
X998_RS13620	COG1070	Carbohydrate kinase
X998_RS13660	COG1846	Transcriptional regulator
X998_RS13665	COG3583	domain protein
X998_RS13700	COG0494	nUDIX hydrolase
X998_RS13790	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
X998_RS13795	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
X998_RS13825	COG0747	negative chemotaxis
X998_RS13830	COG0601	transmembrane transport
X998_RS13835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
X998_RS13840	COG0444	Belongs to the ABC transporter superfamily
X998_RS13845	COG1124	(ABC) transporter
X998_RS13860	COG0069	glutamate synthase activity
X998_RS13865	COG4808	Protein conserved in bacteria
X998_RS13885	COG1363	Peptidase, m42
X998_RS13890	COG4619	ABC transporter
X998_RS13895	COG0390	transport system, permease component
X998_RS13900	COG2814	Major facilitator Superfamily
X998_RS13905	COG2272	Belongs to the type-B carboxylesterase lipase family
X998_RS13910	COG0531	amino acid
X998_RS13920	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
X998_RS13940	COG1174	glycine betaine transport
X998_RS13950	COG1174	glycine betaine transport
X998_RS13960	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
X998_RS13985	COG0531	amino acid
X998_RS14000	COG1113	amino acid transport
X998_RS14020	COG2814	Major facilitator Superfamily
X998_RS14030	COG1929	Belongs to the glycerate kinase type-1 family
X998_RS14050	COG1132	(ABC) transporter
X998_RS14050	COG2375	cellular response to nickel ion
X998_RS14055	COG1132	(ABC) transporter
X998_RS14070	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
X998_RS14075	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
X998_RS14085	COG0156	8-amino-7-oxononanoate synthase activity
X998_RS14135	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
X998_RS14155	COG2814	Major facilitator Superfamily
X998_RS14160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
X998_RS14165	COG0765	amino acid transport
X998_RS14170	COG1126	abc transporter atp-binding protein
X998_RS14210	COG3443	Belongs to the bacterial solute-binding protein 9 family
X998_RS14210	COG0803	Belongs to the bacterial solute-binding protein 9 family
X998_RS14225	COG2116	formate transmembrane transporter activity
X998_RS14230	COG0454	-acetyltransferase
X998_RS14240	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
X998_RS14245	COG2146	nitrite reductase [NAD(P)H] activity
X998_RS14255	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
X998_RS14260	COG1140	nitrate reductase beta subunit
X998_RS14270	COG2181	nitrate reductase activity
X998_RS14290	COG0789	Transcriptional regulator
X998_RS14330	COG3871	stress protein (general stress protein 26)
X998_RS14345	COG1263	PTS System
X998_RS14345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
X998_RS14360	COG1511	domain protein
X998_RS14385	COG0456	acetyltransferase
X998_RS14390	COG0604	alcohol dehydrogenase
X998_RS14410	COG1620	l-lactate permease
X998_RS14480	COG2814	Major facilitator Superfamily
X998_RS14490	COG1566	PFAM secretion protein HlyD family protein
X998_RS14495	COG2814	Major facilitator Superfamily
X998_RS14505	COG0657	acetylesterase activity
X998_RS14520	COG0598	Magnesium transport protein CorA
X998_RS14530	COG0786	glutamate:sodium symporter activity
X998_RS14545	COG3152	Membrane
X998_RS14550	COG4152	abc transporter atp-binding protein
X998_RS14555	COG1668	transmembrane transport
X998_RS14575	COG2258	MOSC domain
X998_RS14600	COG0583	DNA-binding transcription factor activity