locus-tag	class	description
HH313_RS00020	COG2501	S4 domain
HH313_RS00040	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HH313_RS00065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HH313_RS00075	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HH313_RS00085	COG0305	Participates in initiation and elongation during chromosome replication
HH313_RS00115	COG4863	YycH protein
HH313_RS00125	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HH313_RS00130	COG0737	Belongs to the 5'-nucleotidase family
HH313_RS00155	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HH313_RS00155	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HH313_RS00200	COG0584	glycerophosphoryl diester phosphodiesterase
HH313_RS00205	COG2030	dehydratase
HH313_RS00265	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HH313_RS00290	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HH313_RS00300	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HH313_RS00305	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HH313_RS00310	COG0210	DNA helicase
HH313_RS00320	COG0076	glutamate decarboxylase activity
HH313_RS00360	COG1522	sequence-specific DNA binding
HH313_RS00365	COG0456	acetyltransferase
HH313_RS00390	COG0655	NAD(P)H dehydrogenase (quinone) activity
HH313_RS00425	COG0823	Involved in the tonB-independent uptake of proteins
HH313_RS00440	COG1473	amidohydrolase
HH313_RS00450	COG1283	sodium-dependent phosphate transmembrane transporter activity
HH313_RS00455	COG4716	Myosin-crossreactive antigen
HH313_RS00460	COG0697	spore germination
HH313_RS00475	COG1620	l-lactate permease
HH313_RS00495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HH313_RS00500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HH313_RS00505	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HH313_RS00515	COG2423	ornithine cyclodeaminase activity
HH313_RS00520	COG4264	IucA IucC family
HH313_RS00525	COG2814	Major facilitator Superfamily
HH313_RS00530	COG4264	IucA IucC family
HH313_RS00535	COG4264	IucA IucC family
HH313_RS00545	COG0019	diaminopimelate decarboxylase activity
HH313_RS00550	COG1475	DNA binding
HH313_RS00575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HH313_RS00580	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HH313_RS00585	COG0438	transferase activity, transferring glycosyl groups
HH313_RS00615	COG0813	purine-nucleoside phosphorylase activity
HH313_RS00620	COG2814	Major facilitator Superfamily
HH313_RS00640	COG3639	organic phosphonate transmembrane transporter activity
HH313_RS00660	COG0737	Belongs to the 5'-nucleotidase family
HH313_RS00675	COG1454	alcohol dehydrogenase
HH313_RS00675	COG1012	belongs to the aldehyde dehydrogenase family
HH313_RS00700	COG1086	Polysaccharide biosynthesis protein
HH313_RS00710	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HH313_RS00740	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HH313_RS00750	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HH313_RS00755	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HH313_RS00765	COG2832	Protein of unknown function (DUF454)
HH313_RS00800	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HH313_RS00805	COG1960	acyl-CoA dehydrogenase activity
HH313_RS00825	COG3477	response to acidic pH
HH313_RS00850	COG1114	Component of the transport system for branched-chain amino acids
HH313_RS00855	COG1335	isochorismatase
HH313_RS00860	COG3961	Belongs to the TPP enzyme family
HH313_RS00890	COG1737	Transcriptional regulator
HH313_RS00920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HH313_RS00930	COG0405	Gamma-glutamyltransferase
HH313_RS00950	COG3842	ATPase activity
HH313_RS00960	COG1175	transmembrane transport
HH313_RS00965	COG3833	ABC-type maltose transport systems, permease component
HH313_RS00970	COG0673	inositol 2-dehydrogenase activity
HH313_RS00975	COG0673	inositol 2-dehydrogenase activity
HH313_RS00985	COG1755	Isoprenylcysteine carboxyl methyltransferase
HH313_RS01040	COG0183	Belongs to the thiolase family
HH313_RS01050	COG1960	acyl-CoA dehydrogenase activity
HH313_RS01055	COG0318	PFAM AMP-dependent synthetase and ligase
HH313_RS01070	COG0747	negative chemotaxis
HH313_RS01075	COG3189	MarR family transcriptional regulator
HH313_RS01100	COG2190	(PTS) system
HH313_RS01100	COG1263	PTS System
HH313_RS01100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HH313_RS01105	COG1957	nucleoside hydrolase
HH313_RS01125	COG3414	Phosphotransferase system galactitol-specific IIB component
HH313_RS01130	COG3775	system Galactitol-specific IIC component
HH313_RS01135	COG1063	alcohol dehydrogenase
HH313_RS01145	COG1063	alcohol dehydrogenase
HH313_RS01155	COG1063	alcohol dehydrogenase
HH313_RS01160	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HH313_RS01165	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HH313_RS01175	COG1063	alcohol dehydrogenase
HH313_RS01180	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HH313_RS01215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HH313_RS01220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HH313_RS01220	COG2190	(PTS) system
HH313_RS01220	COG1263	PTS System
HH313_RS01230	COG2226	methyltransferase
HH313_RS01285	COG1131	(ABC) transporter
HH313_RS01305	COG3942	CHAP domain
HH313_RS01305	COG1388	LysM domain
HH313_RS01430	COG1114	Component of the transport system for branched-chain amino acids
HH313_RS01435	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HH313_RS01440	COG0577	efflux transmembrane transporter activity
HH313_RS01465	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HH313_RS01470	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HH313_RS01520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HH313_RS01545	COG3037	sugar-specific permease SgaT UlaA
HH313_RS01555	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HH313_RS01560	COG3711	transcriptional antiterminator
HH313_RS01580	COG2271	Major facilitator Superfamily
HH313_RS01585	COG0346	lactoylglutathione lyase activity
HH313_RS01590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HH313_RS01595	COG0431	NADPH-dependent FMN reductase
HH313_RS01605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HH313_RS01610	COG2822	iron ion transport
HH313_RS01620	COG0672	)-iron permease
HH313_RS01625	COG0805	protein transport
HH313_RS01630	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HH313_RS01640	COG1476	TRANSCRIPTIONal
HH313_RS01650	COG1131	(ABC) transporter
HH313_RS01680	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HH313_RS01680	COG0646	methionine synthase
HH313_RS01685	COG0626	cystathionine gamma-synthase activity
HH313_RS01690	COG0626	cystathionine gamma-synthase activity
HH313_RS01695	COG1475	DNA binding
HH313_RS01700	COG0668	transmembrane transport
HH313_RS01705	COG4481	Protein conserved in bacteria
HH313_RS01710	COG0012	GTP binding
HH313_RS01820	COG1823	symporter activity
HH313_RS01850	COG2233	PERMEase
HH313_RS01900	COG1683	Conserved Protein
HH313_RS01910	COG3759	membrane
HH313_RS02070	COG0523	cobalamin synthesis protein
HH313_RS02095	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HH313_RS02105	COG5609	conserved protein (DUF2294)
HH313_RS02120	COG1647	Serine aminopeptidase, S33
HH313_RS02125	COG0733	neurotransmitter:sodium symporter activity
HH313_RS02130	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HH313_RS02135	COG0626	cystathionine gamma-synthase activity
HH313_RS02145	COG2011	ABC-type metal ion transport system permease component
HH313_RS02150	COG1464	Belongs to the NlpA lipoprotein family
HH313_RS02165	COG0494	nUDIX hydrolase
HH313_RS02185	COG0583	DNA-binding transcription factor activity
HH313_RS02190	COG0067	glutamate synthase
HH313_RS02190	COG0069	glutamate synthase activity
HH313_RS02190	COG0070	glutamate synthase
HH313_RS02195	COG0493	'glutamate synthase
HH313_RS02205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HH313_RS02205	COG1263	PTS System
HH313_RS02210	COG0366	Alpha amylase catalytic
HH313_RS02215	COG2188	Transcriptional regulator
HH313_RS02235	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HH313_RS02270	COG1982	Orn Lys Arg decarboxylase major
HH313_RS02280	COG3870	Protein conserved in bacteria
HH313_RS02285	COG0470	DNA polymerase III
HH313_RS02290	COG1774	PSP1 C-terminal conserved region
HH313_RS02300	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HH313_RS02310	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HH313_RS02320	COG0084	hydrolase, TatD family'
HH313_RS02325	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HH313_RS02335	COG4466	Protein conserved in bacteria
HH313_RS02345	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HH313_RS02350	COG0251	oxidation-reduction process
HH313_RS02395	COG2244	polysaccharide biosynthetic process
HH313_RS02400	COG3956	TIGRFAM MazG family protein
HH313_RS02405	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HH313_RS02415	COG1098	S1 RNA binding domain
HH313_RS02430	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HH313_RS02455	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HH313_RS02550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HH313_RS02565	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HH313_RS02575	COG3880	PFAM UvrB UvrC protein
HH313_RS02590	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HH313_RS02595	COG4956	integral membrane protein (PIN domain superfamily)
HH313_RS02615	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HH313_RS02670	COG2813	Specifically methylates the guanine in position
HH313_RS02710	COG1473	amidohydrolase
HH313_RS02740	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HH313_RS02745	COG1428	Deoxynucleoside kinase
HH313_RS02750	COG1428	Deoxynucleoside kinase
HH313_RS02760	COG0561	phosphatase activity
HH313_RS02805	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HH313_RS02915	COG0095	Lipoate-protein ligase
HH313_RS02920	COG0083	homoserine kinase activity
HH313_RS02940	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HH313_RS02990	COG0667	Aldo Keto reductase
HH313_RS02995	COG0655	NAD(P)H dehydrogenase (quinone) activity
HH313_RS03005	COG1078	dGTPase activity
HH313_RS03035	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HH313_RS03040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HH313_RS03090	COG4974	Belongs to the 'phage' integrase family
HH313_RS03135	COG0803	Belongs to the bacterial solute-binding protein 9 family
HH313_RS03140	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HH313_RS03145	COG1121	(ABC) transporter
HH313_RS03150	COG1321	iron dependent repressor
HH313_RS03160	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HH313_RS03170	COG1682	transport, permease protein
HH313_RS03175	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HH313_RS03185	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HH313_RS03190	COG1686	Belongs to the peptidase S11 family
HH313_RS03195	COG1132	(ABC) transporter
HH313_RS03200	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HH313_RS03210	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HH313_RS03215	COG1120	ATPase activity
HH313_RS03220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HH313_RS03225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HH313_RS03230	COG2376	Dihydroxyacetone kinase
HH313_RS03240	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HH313_RS03250	COG3949	Membrane
HH313_RS03270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HH313_RS03285	COG1136	(ABC) transporter
HH313_RS03290	COG0577	efflux transmembrane transporter activity
HH313_RS03295	COG1392	Phosphate transport regulator
HH313_RS03300	COG0306	phosphate transporter
HH313_RS03305	COG3942	CHAP domain
HH313_RS03305	COG1388	LysM domain
HH313_RS03315	COG4977	sequence-specific DNA binding
HH313_RS03315	COG1917	Cupin 2, conserved barrel domain protein
HH313_RS03345	COG0583	DNA-binding transcription factor activity
HH313_RS03355	COG2839	Protein conserved in bacteria
HH313_RS03385	COG1611	Belongs to the LOG family
HH313_RS03405	COG4988	ABC transporter
HH313_RS03410	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HH313_RS03420	COG0523	cobalamin synthesis protein
HH313_RS03425	COG4989	oxidoreductase activity
HH313_RS03435	COG0471	metal ion transport
HH313_RS03470	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HH313_RS03475	COG1349	DNA-binding transcription factor activity
HH313_RS03480	COG1105	Belongs to the carbohydrate kinase PfkB family
HH313_RS03485	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HH313_RS03485	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HH313_RS03485	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HH313_RS03490	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HH313_RS03495	COG1253	flavin adenine dinucleotide binding
HH313_RS03500	COG0656	L-ascorbic acid biosynthetic process
HH313_RS03505	COG0463	Glycosyl transferase, family 2
HH313_RS03540	COG0720	synthase
HH313_RS03550	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HH313_RS03550	COG0512	Glutamine amidotransferase of anthranilate synthase
HH313_RS03555	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HH313_RS03585	COG0488	(ABC) transporter
HH313_RS03590	COG0514	ATP-dependent DNA helicase (RecQ)
HH313_RS03595	COG0517	IMP dehydrogenase activity
HH313_RS03595	COG1125	glycine betaine transport
HH313_RS03600	COG1174	glycine betaine transport
HH313_RS03625	COG3104	oligopeptide transport
HH313_RS03645	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HH313_RS03650	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HH313_RS03660	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HH313_RS03665	COG4605	iron ion homeostasis
HH313_RS03670	COG4604	ABC transporter, ATP-binding protein
HH313_RS03675	COG4607	ABC-type enterochelin transport system periplasmic component
HH313_RS03730	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HH313_RS03735	COG1739	Uncharacterized protein family UPF0029
HH313_RS03745	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HH313_RS03750	COG1040	competence protein
HH313_RS03780	COG1388	LysM domain
HH313_RS03780	COG3942	CHAP domain
HH313_RS03835	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HH313_RS03850	COG0281	malic enzyme
HH313_RS03900	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HH313_RS03905	COG1647	Serine aminopeptidase, S33
HH313_RS03910	COG0557	exoribonuclease II activity
HH313_RS03975	COG1278	Cold shock
HH313_RS04015	COG0406	alpha-ribazole phosphatase activity
HH313_RS04020	COG1279	arginine transmembrane transporter activity
HH313_RS04045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HH313_RS04050	COG1393	Belongs to the ArsC family
HH313_RS04060	COG3878	Protein conserved in bacteria
HH313_RS04065	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HH313_RS04080	COG2011	ABC-type metal ion transport system permease component
HH313_RS04085	COG1464	Belongs to the NlpA lipoprotein family
HH313_RS04090	COG0582	viral genome integration into host DNA
HH313_RS04195	COG5484	DNA packaging
HH313_RS04195	COG3728	DNA packaging
HH313_RS04235	COG0396	ATPase activity
HH313_RS04240	COG0719	Fe-S assembly protein
HH313_RS04250	COG0822	iron-sulfur transferase activity
HH313_RS04270	COG1253	flavin adenine dinucleotide binding
HH313_RS04285	COG1801	Protein of unknown function DUF72
HH313_RS04290	COG0730	response to heat
HH313_RS04305	COG4470	Protein conserved in bacteria
HH313_RS04315	COG2445	Protein of unknown function DUF86
HH313_RS04345	COG1696	Membrane protein involved in D-alanine export
HH313_RS04355	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HH313_RS04360	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HH313_RS04365	COG4837	Protein of unknown function (DUF1462)
HH313_RS04370	COG1252	NADH dehydrogenase
HH313_RS04380	COG0316	Belongs to the HesB IscA family
HH313_RS04390	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HH313_RS04395	COG2056	Na+-H+ antiporter family
HH313_RS04400	COG2050	protein possibly involved in aromatic compounds catabolism
HH313_RS04455	COG1098	S1 RNA binding domain
HH313_RS04460	COG1902	pentaerythritol trinitrate reductase activity
HH313_RS04475	COG0584	glycerophosphoryl diester phosphodiesterase
HH313_RS04495	COG0398	Pfam SNARE associated Golgi protein
HH313_RS04535	COG0561	phosphatase activity
HH313_RS04560	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HH313_RS04575	COG1881	PFAM PEBP family protein
HH313_RS04605	COG0601	transmembrane transport
HH313_RS04610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HH313_RS04615	COG0444	Belongs to the ABC transporter superfamily
HH313_RS04620	COG4608	Belongs to the ABC transporter superfamily
HH313_RS04625	COG4166	transmembrane transport
HH313_RS04630	COG0747	negative chemotaxis
HH313_RS04635	COG0444	Belongs to the ABC transporter superfamily
HH313_RS04640	COG4608	Belongs to the ABC transporter superfamily
HH313_RS04645	COG0601	transmembrane transport
HH313_RS04650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HH313_RS04680	COG1164	Oligoendopeptidase f
HH313_RS04690	COG2346	COG2346, Truncated hemoglobins
HH313_RS04705	COG2357	RelA SpoT domain protein
HH313_RS04715	COG0564	pseudouridine synthase activity
HH313_RS04720	COG2239	Acts as a magnesium transporter
HH313_RS04725	COG0475	glutathione-regulated potassium exporter activity
HH313_RS04725	COG0569	domain protein
HH313_RS04735	COG0628	permease
HH313_RS04740	COG1115	amino acid carrier protein
HH313_RS04790	COG0861	Integral membrane protein TerC family
HH313_RS04800	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HH313_RS04805	COG0737	Belongs to the 5'-nucleotidase family
HH313_RS04820	COG4903	ComK protein
HH313_RS04835	COG4873	Protein conserved in bacteria
HH313_RS04895	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HH313_RS04905	COG2314	TM2 domain
HH313_RS04910	COG0456	acetyltransferase
HH313_RS04915	COG1575	Belongs to the MenA family. Type 1 subfamily
HH313_RS04920	COG1169	isochorismate synthase
HH313_RS04930	COG2267	carboxylic ester hydrolase activity
HH313_RS04955	COG0436	Aminotransferase
HH313_RS04960	COG3594	Acyltransferase
HH313_RS04990	COG1316	TRANSCRIPTIONal
HH313_RS05035	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HH313_RS05050	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HH313_RS05090	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HH313_RS05095	COG4172	Belongs to the ABC transporter superfamily
HH313_RS05100	COG4721	ABC-type cobalt transport system, permease component
HH313_RS05115	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HH313_RS05135	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HH313_RS05140	COG1271	oxidase subunit
HH313_RS05145	COG1294	oxidase, subunit
HH313_RS05150	COG0569	domain protein
HH313_RS05215	COG1176	ABC-type spermidine putrescine transport system, permease component I
HH313_RS05220	COG1177	transmembrane transport
HH313_RS05225	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HH313_RS05250	COG0483	inositol monophosphate 1-phosphatase activity
HH313_RS05270	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HH313_RS05280	COG0772	Belongs to the SEDS family
HH313_RS05310	COG3679	Belongs to the UPF0342 family
HH313_RS05330	COG0742	ribosomal rna small subunit methyltransferase
HH313_RS05385	COG4509	Sortase family
HH313_RS05400	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HH313_RS05430	COG1796	DNA polymerase
HH313_RS05430	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HH313_RS05455	COG2009	succinate dehydrogenase
HH313_RS05460	COG1053	succinate dehydrogenase
HH313_RS05465	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HH313_RS05570	COG1288	antiporter activity
HH313_RS05605	COG1011	Hydrolase
HH313_RS05630	COG4839	cell division protein FtsL
HH313_RS05650	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HH313_RS05655	COG0849	cell division
HH313_RS05670	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HH313_RS05680	COG0762	integral membrane protein
HH313_RS05685	COG2302	S4 RNA-binding domain
HH313_RS05690	COG3599	regulation of cell shape
HH313_RS05700	COG2514	catechol 2,3-dioxygenase activity
HH313_RS05715	COG0564	pseudouridine synthase activity
HH313_RS05725	COG2233	PERMEase
HH313_RS05770	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HH313_RS05785	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HH313_RS05790	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HH313_RS05800	COG2314	TM2 domain
HH313_RS05815	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HH313_RS05815	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HH313_RS05825	COG0631	protein serine/threonine phosphatase activity
HH313_RS05840	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HH313_RS05855	COG1302	Protein conserved in bacteria
HH313_RS05900	COG1196	nuclear chromosome segregation
HH313_RS05905	COG0552	protein localization to endoplasmic reticulum
HH313_RS05915	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HH313_RS05970	COG2348	transferase activity, transferring amino-acyl groups
HH313_RS05975	COG0758	DNA mediated transformation
HH313_RS06070	COG0195	Participates in both transcription termination and antitermination
HH313_RS06075	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HH313_RS06100	COG0196	riboflavin kinase activity
HH313_RS06125	COG2188	Transcriptional regulator
HH313_RS06130	COG0612	Peptidase, M16
HH313_RS06135	COG0612	Peptidase, M16
HH313_RS06140	COG0300	oxidoreductase activity
HH313_RS06160	COG1546	Belongs to the CinA family
HH313_RS06160	COG1058	Belongs to the CinA family
HH313_RS06180	COG1692	metallophosphoesterase
HH313_RS06185	COG0674	pyruvate-flavodoxin oxidoreductase activity
HH313_RS06185	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HH313_RS06190	COG1013	pyruvate-flavodoxin oxidoreductase activity
HH313_RS06225	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HH313_RS06230	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HH313_RS06255	COG1923	regulation of RNA biosynthetic process
HH313_RS06270	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HH313_RS06275	COG0789	Transcriptional regulator
HH313_RS06405	COG1525	nuclease
HH313_RS06420	COG0527	aspartate kinase activity
HH313_RS06425	COG0460	homoserine dehydrogenase
HH313_RS06430	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HH313_RS06455	COG0833	amino acid
HH313_RS06480	COG2340	Cysteine-rich secretory protein family
HH313_RS06515	COG4846	Membrane protein involved in cytochrome C biogenesis
HH313_RS06535	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HH313_RS06545	COG0824	Thioesterase
HH313_RS06565	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HH313_RS06570	COG1115	amino acid carrier protein
HH313_RS06585	COG0628	permease
HH313_RS06610	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HH313_RS06620	COG1363	Peptidase, m42
HH313_RS06625	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HH313_RS06630	COG0512	Glutamine amidotransferase of anthranilate synthase
HH313_RS06670	COG0561	phosphatase activity
HH313_RS06715	COG0704	Plays a role in the regulation of phosphate uptake
HH313_RS06725	COG0581	inorganic phosphate transmembrane transporter activity
HH313_RS06730	COG0573	inorganic phosphate transmembrane transporter activity
HH313_RS06745	COG0488	(ABC) transporter
HH313_RS06750	COG0527	aspartate kinase activity
HH313_RS06755	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HH313_RS06790	COG2808	Putative FMN-binding domain
HH313_RS06830	COG4548	von Willebrand factor, type A
HH313_RS06835	COG0714	Associated with various cellular activities
HH313_RS06875	COG0671	phosphoesterase, PA-phosphatase related
HH313_RS06950	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HH313_RS06970	COG0531	amino acid
HH313_RS06985	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HH313_RS06990	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HH313_RS07005	COG0116	Belongs to the methyltransferase superfamily
HH313_RS07040	COG4499	WXG100 protein secretion system (Wss), protein YukC
HH313_RS07040	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HH313_RS07050	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HH313_RS07055	COG3935	DnaD domain protein
HH313_RS07080	COG0438	transferase activity, transferring glycosyl groups
HH313_RS07085	COG1694	Mazg nucleotide pyrophosphohydrolase
HH313_RS07090	COG2738	Putative neutral zinc metallopeptidase
HH313_RS07095	COG4347	Protein of unknown function (DUF1405)
HH313_RS07135	COG0142	geranyltranstransferase activity
HH313_RS07190	COG0492	ferredoxin-NADP+ reductase activity
HH313_RS07205	COG0514	ATP-dependent DNA helicase (RecQ)
HH313_RS07215	COG1141	Ferredoxin
HH313_RS07255	COG0860	N-Acetylmuramoyl-L-alanine amidase
HH313_RS07255	COG1388	LysM domain
HH313_RS07340	COG0740	serine-type endopeptidase activity
HH313_RS07455	COG1484	DNA-dependent DNA replication
HH313_RS07480	COG0629	single-stranded DNA binding
HH313_RS07600	COG0582	viral genome integration into host DNA
HH313_RS07615	COG5002	protein histidine kinase activity
HH313_RS07620	COG0745	RESPONSE REGULATOR receiver
HH313_RS07625	COG1187	pseudouridine synthase activity
HH313_RS07650	COG0735	belongs to the Fur family
HH313_RS07655	COG0494	nUDIX hydrolase
HH313_RS07660	COG0667	Aldo Keto reductase
HH313_RS07670	COG4221	oxidoreductase activity
HH313_RS07685	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HH313_RS07695	COG0366	Alpha amylase catalytic
HH313_RS07700	COG1609	Transcriptional regulator
HH313_RS07720	COG2195	Cleaves the N-terminal amino acid of tripeptides
HH313_RS07730	COG4129	membrane
HH313_RS07740	COG0508	dehydrogenase complex catalyzes the overall conversion of
HH313_RS07745	COG0022	dehydrogenase e1 component
HH313_RS07750	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HH313_RS07755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HH313_RS07760	COG0497	DNA recombination
HH313_RS07790	COG1302	Protein conserved in bacteria
HH313_RS07795	COG0439	Biotin carboxylase
HH313_RS07800	COG0511	ligase activity, forming carbon-carbon bonds
HH313_RS07810	COG0006	proline dipeptidase activity
HH313_RS07825	COG0095	Lipoate-protein ligase
HH313_RS07830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HH313_RS07875	COG4537	Required for transformation and DNA binding
HH313_RS07880	COG1459	type II secretion system
HH313_RS07885	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HH313_RS07890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HH313_RS07895	COG0011	TIGRFAM Protein of
HH313_RS07900	COG1940	carbohydrate kinase activity
HH313_RS07905	COG4483	Protein conserved in bacteria
HH313_RS07915	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HH313_RS07940	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HH313_RS07945	COG1121	(ABC) transporter
HH313_RS07955	COG0513	Belongs to the DEAD box helicase family
HH313_RS07965	COG2384	SAM-dependent methyltransferase
HH313_RS07985	COG0517	IMP dehydrogenase activity
HH313_RS08005	COG0295	cytidine deaminase activity
HH313_RS08010	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HH313_RS08020	COG1702	phosphate starvation-inducible protein PhoH
HH313_RS08035	COG1030	water channel activity
HH313_RS08045	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HH313_RS08050	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HH313_RS08080	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HH313_RS08095	COG1466	dna polymerase III delta subunit
HH313_RS08100	COG2333	competence protein COMEC
HH313_RS08100	COG0658	competence protein
HH313_RS08105	COG2131	deaminase
HH313_RS08115	COG2226	methyltransferase
HH313_RS08120	COG0799	negative regulation of ribosome biogenesis
HH313_RS08125	COG1713	HD superfamily hydrolase involved in NAD metabolism
HH313_RS08135	COG1534	Rna-binding protein
HH313_RS08145	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HH313_RS08150	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HH313_RS08175	COG3177	Filamentation induced by cAMP protein fic
HH313_RS08180	COG1914	H( )-stimulated, divalent metal cation uptake system
HH313_RS08190	COG0439	Biotin carboxylase
HH313_RS08195	COG0511	ligase activity, forming carbon-carbon bonds
HH313_RS08200	COG1984	allophanate hydrolase subunit 2
HH313_RS08205	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HH313_RS08255	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HH313_RS08270	COG1104	cysteine desulfurase activity
HH313_RS08275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HH313_RS08285	COG3237	CsbD-like
HH313_RS08290	COG1959	2 iron, 2 sulfur cluster binding
HH313_RS08295	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HH313_RS08300	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HH313_RS08345	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HH313_RS08345	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HH313_RS08350	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HH313_RS08350	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HH313_RS08355	COG1862	Preprotein translocase
HH313_RS08395	COG2868	ribosomal protein
HH313_RS08440	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HH313_RS08445	COG0285	dihydrofolate synthase activity
HH313_RS08455	COG2818	Glycosylase
HH313_RS08490	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HH313_RS08525	COG4112	unkown
HH313_RS08545	COG0833	amino acid
HH313_RS08560	COG1484	DNA-dependent DNA replication
HH313_RS08590	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HH313_RS08590	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HH313_RS08600	COG5002	protein histidine kinase activity
HH313_RS08605	COG0745	RESPONSE REGULATOR receiver
HH313_RS08615	COG0372	Belongs to the citrate synthase family
HH313_RS08620	COG1113	amino acid transport
HH313_RS08645	COG0281	malic enzyme
HH313_RS08655	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HH313_RS08660	COG4109	DRTGG domain
HH313_RS08700	COG0827	DNA restriction-modification system
HH313_RS08710	COG0730	response to heat
HH313_RS08720	COG1104	cysteine desulfurase activity
HH313_RS08730	COG1956	GAF domain-containing protein
HH313_RS08740	COG0584	glycerophosphoryl diester phosphodiesterase
HH313_RS08745	COG1764	response to oxidative stress
HH313_RS08750	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HH313_RS08755	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HH313_RS08775	COG1263	PTS System
HH313_RS08775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HH313_RS08780	COG0204	Acyl-transferase
HH313_RS08785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HH313_RS08820	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HH313_RS08825	COG0454	-acetyltransferase
HH313_RS08845	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HH313_RS08845	COG1605	Chorismate mutase
HH313_RS08870	COG1674	ftsk spoiiie
HH313_RS08875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HH313_RS08885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HH313_RS08890	COG1363	Peptidase, m42
HH313_RS08900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HH313_RS08910	COG0510	thiamine kinase activity
HH313_RS08930	COG1187	pseudouridine synthase activity
HH313_RS08935	COG2244	polysaccharide biosynthetic process
HH313_RS08940	COG2081	HI0933 family
HH313_RS08960	COG2814	Major facilitator Superfamily
HH313_RS08965	COG1242	4 iron, 4 sulfur cluster binding
HH313_RS08970	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HH313_RS08980	COG2267	carboxylic ester hydrolase activity
HH313_RS09010	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HH313_RS09010	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HH313_RS09035	COG4193	domain, Protein
HH313_RS09035	COG5632	N-Acetylmuramoyl-L-alanine amidase
HH313_RS09035	COG3266	domain, Protein
HH313_RS09070	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HH313_RS09090	COG0656	L-ascorbic acid biosynthetic process
HH313_RS09110	COG1506	peptidase
HH313_RS09115	COG2816	NAD+ diphosphatase activity
HH313_RS09310	COG1131	(ABC) transporter
HH313_RS09315	COG0537	adenosine 5'-monophosphoramidase activity
HH313_RS09345	COG0420	3'-5' exonuclease activity
HH313_RS09365	COG2197	response regulator
HH313_RS09370	COG2203	Gaf domain
HH313_RS09370	COG4585	Histidine kinase
HH313_RS09375	COG0564	pseudouridine synthase activity
HH313_RS09405	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HH313_RS09410	COG1126	abc transporter atp-binding protein
HH313_RS09415	COG0765	amino acid transport
HH313_RS09585	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HH313_RS09590	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HH313_RS09600	COG4129	membrane
HH313_RS09615	COG1194	a g-specific adenine glycosylase
HH313_RS09620	COG1988	membrane-bound metal-dependent
HH313_RS09630	COG1388	LysM domain
HH313_RS09630	COG1134	teichoic acid transport
HH313_RS09680	COG5632	N-Acetylmuramoyl-L-alanine amidase
HH313_RS09680	COG1388	LysM domain
HH313_RS09905	COG1484	DNA-dependent DNA replication
HH313_RS10005	COG4974	Belongs to the 'phage' integrase family
HH313_RS10010	COG0535	radical SAM domain protein
HH313_RS10015	COG1607	acyl-coa hydrolase
HH313_RS10020	COG2309	aminopeptidase activity
HH313_RS10040	COG1295	ribonuclease BN
HH313_RS10155	COG4851	CamS sex pheromone cAM373 precursor
HH313_RS10175	COG4496	protein, YerC YecD
HH313_RS10210	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HH313_RS10220	COG0077	Prephenate dehydratase
HH313_RS10235	COG0471	metal ion transport
HH313_RS10245	COG1335	isochorismatase
HH313_RS10260	COG1012	belongs to the aldehyde dehydrogenase family
HH313_RS10310	COG1131	(ABC) transporter
HH313_RS10325	COG1725	Transcriptional regulator
HH313_RS10370	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HH313_RS10435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HH313_RS10440	COG1621	beta-fructofuranosidase activity
HH313_RS10445	COG1609	Transcriptional regulator
HH313_RS10450	COG0004	ammonium transporteR
HH313_RS10455	COG0425	Belongs to the sulfur carrier protein TusA family
HH313_RS10460	COG2391	methyltransferase activity
HH313_RS10470	COG0488	(ABC) transporter
HH313_RS10485	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HH313_RS10495	COG0456	acetyltransferase
HH313_RS10500	COG1214	PFAM Peptidase M22, glycoprotease
HH313_RS10505	COG0802	atpase or kinase
HH313_RS10520	COG0028	Belongs to the TPP enzyme family
HH313_RS10595	COG2183	response to ionizing radiation
HH313_RS10600	COG1191	sigma factor activity
HH313_RS10610	COG1366	Belongs to the anti-sigma-factor antagonist family
HH313_RS10615	COG2208	phosphoserine phosphatase activity
HH313_RS10645	COG3428	Bacterial PH domain
HH313_RS10675	COG2205	protein histidine kinase activity
HH313_RS10680	COG0745	RESPONSE REGULATOR receiver
HH313_RS10690	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HH313_RS10700	COG0772	Belongs to the SEDS family
HH313_RS10715	COG1937	Protein conserved in bacteria
HH313_RS10725	COG1418	mRNA catabolic process
HH313_RS10760	COG0629	single-stranded DNA binding
HH313_RS10845	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HH313_RS10870	COG0009	L-threonylcarbamoyladenylate synthase
HH313_RS10875	COG2890	protein-(glutamine-N5) methyltransferase activity
HH313_RS10895	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HH313_RS10935	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HH313_RS10980	COG0813	purine-nucleoside phosphorylase activity
HH313_RS10985	COG0783	Belongs to the Dps family
HH313_RS11005	COG1482	cell wall glycoprotein biosynthetic process
HH313_RS11010	COG0702	epimerase
HH313_RS11015	COG0640	Transcriptional regulator
HH313_RS11050	COG0561	phosphatase activity
HH313_RS11055	COG1119	ATPase activity
HH313_RS11070	COG3711	transcriptional antiterminator
HH313_RS11100	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HH313_RS11160	COG0489	protein tyrosine kinase activity
HH313_RS11165	COG2814	Major facilitator Superfamily
HH313_RS11180	COG1272	protein, Hemolysin III
HH313_RS11190	COG1988	membrane-bound metal-dependent
HH313_RS11205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HH313_RS11210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HH313_RS11215	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HH313_RS11225	COG3457	Alanine racemase
HH313_RS11230	COG4264	IucA IucC family
HH313_RS11235	COG2814	Major facilitator Superfamily
HH313_RS11260	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HH313_RS11270	COG2130	NADP-dependent
HH313_RS11335	COG0656	L-ascorbic acid biosynthetic process
HH313_RS11340	COG0789	Transcriptional regulator
HH313_RS11350	COG5492	domain, Protein
HH313_RS11355	COG2378	regulation of single-species biofilm formation
HH313_RS11360	COG0693	protein deglycase activity
HH313_RS11370	COG3527	Alpha-acetolactate decarboxylase
HH313_RS11375	COG0028	Belongs to the TPP enzyme family
HH313_RS11460	COG0201	protein transport
HH313_RS11575	COG2252	PERMEase
HH313_RS11620	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HH313_RS11680	COG1763	Mo-molybdopterin cofactor biosynthetic process
HH313_RS11700	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HH313_RS11705	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HH313_RS11710	COG4149	molybdate abc transporter
HH313_RS11715	COG0725	ABC transporter, periplasmic molybdate-binding protein
HH313_RS11730	COG1268	BioY protein
HH313_RS11745	COG1960	acyl-CoA dehydrogenase activity
HH313_RS11750	COG4413	Urea transporter
HH313_RS11820	COG1757	Na H antiporter
HH313_RS11835	COG3942	CHAP domain
HH313_RS11870	COG1316	TRANSCRIPTIONal
HH313_RS11900	COG1113	amino acid transport
HH313_RS11920	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HH313_RS11925	COG0385	Bile acid
HH313_RS11935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HH313_RS11935	COG1263	PTS System
HH313_RS11940	COG1737	Transcriptional regulator
HH313_RS11960	COG1028	Short-chain dehydrogenase reductase Sdr
HH313_RS11965	COG1473	amidohydrolase
HH313_RS11980	COG0583	DNA-binding transcription factor activity
HH313_RS12000	COG2258	MOSC domain
HH313_RS12020	COG1668	transmembrane transport
HH313_RS12025	COG4152	abc transporter atp-binding protein
HH313_RS12030	COG3152	Membrane
HH313_RS12040	COG0786	glutamate:sodium symporter activity
HH313_RS12050	COG0598	Magnesium transport protein CorA
HH313_RS12065	COG0657	acetylesterase activity
HH313_RS12075	COG2814	Major facilitator Superfamily
HH313_RS12080	COG1566	PFAM secretion protein HlyD family protein
HH313_RS12095	COG2814	Major facilitator Superfamily
HH313_RS12155	COG1131	(ABC) transporter
HH313_RS12170	COG1620	l-lactate permease
HH313_RS12190	COG0604	alcohol dehydrogenase
HH313_RS12215	COG1511	domain protein
HH313_RS12230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HH313_RS12230	COG1263	PTS System
HH313_RS12245	COG3871	stress protein (general stress protein 26)
HH313_RS12285	COG0789	Transcriptional regulator
HH313_RS12305	COG2181	nitrate reductase activity
HH313_RS12315	COG1140	nitrate reductase beta subunit
HH313_RS12320	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HH313_RS12330	COG2146	nitrite reductase [NAD(P)H] activity
HH313_RS12335	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HH313_RS12345	COG0454	-acetyltransferase
HH313_RS12350	COG2116	formate transmembrane transporter activity
HH313_RS12365	COG0803	Belongs to the bacterial solute-binding protein 9 family
HH313_RS12365	COG3443	Belongs to the bacterial solute-binding protein 9 family
HH313_RS12400	COG1126	abc transporter atp-binding protein
HH313_RS12405	COG0765	amino acid transport
HH313_RS12410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HH313_RS12415	COG2814	Major facilitator Superfamily
HH313_RS12430	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HH313_RS12470	COG0156	8-amino-7-oxononanoate synthase activity
HH313_RS12480	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HH313_RS12485	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HH313_RS12495	COG1132	(ABC) transporter
HH313_RS12515	COG1929	Belongs to the glycerate kinase type-1 family
HH313_RS12525	COG2814	Major facilitator Superfamily
HH313_RS12540	COG1408	metallophosphoesterase
HH313_RS12545	COG1113	amino acid transport
HH313_RS12555	COG0531	amino acid
HH313_RS12570	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HH313_RS12580	COG1174	glycine betaine transport
HH313_RS12590	COG1174	glycine betaine transport
HH313_RS12610	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
HH313_RS12615	COG0531	amino acid
HH313_RS12620	COG2272	Belongs to the type-B carboxylesterase lipase family
HH313_RS12625	COG2814	Major facilitator Superfamily
HH313_RS12630	COG0390	transport system, permease component
HH313_RS12635	COG4619	ABC transporter
HH313_RS12640	COG1363	Peptidase, m42
HH313_RS12645	COG4808	Protein conserved in bacteria
HH313_RS12650	COG0069	glutamate synthase activity
HH313_RS12665	COG1124	(ABC) transporter
HH313_RS12675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HH313_RS12680	COG0601	transmembrane transport
HH313_RS12685	COG0747	negative chemotaxis
HH313_RS12710	COG1028	Short-chain dehydrogenase reductase Sdr
HH313_RS12715	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HH313_RS12720	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HH313_RS12820	COG0494	nUDIX hydrolase
HH313_RS12860	COG1846	Transcriptional regulator
HH313_RS12890	COG1070	Carbohydrate kinase
HH313_RS12895	COG1802	Transcriptional regulator
HH313_RS12900	COG0789	Transcriptional regulator
HH313_RS12905	COG2357	RelA SpoT domain protein
HH313_RS12910	COG4876	unkown
HH313_RS12920	COG2271	Major facilitator Superfamily
HH313_RS12925	COG0586	Pfam SNARE associated Golgi protein
HH313_RS12935	COG1131	(ABC) transporter
HH313_RS12945	COG1073	alpha beta
HH313_RS12955	COG1073	alpha beta
HH313_RS12980	COG3949	Membrane
HH313_RS12985	COG0400	carboxylic ester hydrolase activity
HH313_RS12990	COG0346	lactoylglutathione lyase activity
HH313_RS12995	COG1846	Transcriptional regulator
HH313_RS13010	COG2514	catechol 2,3-dioxygenase activity
HH313_RS13025	COG0561	phosphatase activity
HH313_RS13030	COG1131	(ABC) transporter
HH313_RS13040	COG3764	Sortase (surface protein transpeptidase)
HH313_RS13060	COG1760	l-serine dehydratase
HH313_RS13065	COG1760	l-serine dehydratase
HH313_RS13080	COG0697	spore germination
HH313_RS13085	COG0657	acetylesterase activity
HH313_RS13105	COG0028	Belongs to the TPP enzyme family
HH313_RS13120	COG0583	DNA-binding transcription factor activity
HH313_RS13130	COG3942	CHAP domain
HH313_RS13140	COG3425	synthase
HH313_RS13150	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HH313_RS13175	COG2409	Drug exporters of the RND superfamily
HH313_RS13220	COG0436	Aminotransferase
HH313_RS13260	COG0456	acetyltransferase
HH313_RS13325	COG0596	Alpha beta hydrolase
HH313_RS13360	COG3001	Fructosamine kinase
HH313_RS13365	COG0167	dihydroorotate dehydrogenase activity
HH313_RS13450	COG2226	methyltransferase
HH313_RS13485	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HH313_RS13570	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HH313_RS13575	COG3527	Alpha-acetolactate decarboxylase
HH313_RS13585	COG0531	amino acid
HH313_RS13615	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HH313_RS13635	COG1012	belongs to the aldehyde dehydrogenase family
HH313_RS13645	COG1510	regulation of RNA biosynthetic process
HH313_RS13650	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HH313_RS13675	COG2851	Citrate transporter
HH313_RS13685	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HH313_RS13695	COG0386	Belongs to the glutathione peroxidase family
HH313_RS13715	COG1136	(ABC) transporter
HH313_RS13720	COG2205	protein histidine kinase activity
HH313_RS13725	COG0745	RESPONSE REGULATOR receiver
HH313_RS13735	COG1785	Belongs to the alkaline phosphatase family
HH313_RS13745	COG1846	Transcriptional regulator
HH313_RS13790	COG1438	arginine binding
HH313_RS13810	COG3711	transcriptional antiterminator
HH313_RS13810	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HH313_RS13815	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HH313_RS13815	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HH313_RS13815	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HH313_RS13820	COG1482	cell wall glycoprotein biosynthetic process
HH313_RS13830	COG1705	Flagellar rod assembly protein muramidase FlgJ
HH313_RS13830	COG3942	CHAP domain
HH313_RS13835	COG3433	isochorismatase activity
HH313_RS13835	COG1535	isochorismatase
HH313_RS13850	COG0438	transferase activity, transferring glycosyl groups
HH313_RS13865	COG1073	alpha beta
HH313_RS13885	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HH313_RS13915	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HH313_RS14000	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HH313_RS14085	COG0471	metal ion transport
HH313_RS14090	COG2962	Rard protein
HH313_RS14100	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HH313_RS14120	COG1136	(ABC) transporter
HH313_RS14125	COG0577	efflux transmembrane transporter activity
HH313_RS14160	COG1278	Cold shock
HH313_RS14180	COG1475	DNA binding