locus-tag	class	description
A2U18_RS00015	COG2501	S4 domain
A2U18_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A2U18_RS00065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A2U18_RS00075	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
A2U18_RS00085	COG0305	Participates in initiation and elongation during chromosome replication
A2U18_RS00120	COG4863	YycH protein
A2U18_RS00130	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A2U18_RS00135	COG0737	Belongs to the 5'-nucleotidase family
A2U18_RS00160	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A2U18_RS00160	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A2U18_RS00200	COG3425	synthase
A2U18_RS00210	COG0584	glycerophosphoryl diester phosphodiesterase
A2U18_RS00215	COG2030	dehydratase
A2U18_RS00310	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A2U18_RS00335	COG0640	Transcriptional regulator
A2U18_RS00345	COG2217	Heavy metal translocating P-type atpase
A2U18_RS00350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A2U18_RS00355	COG2210	Belongs to the sulfur carrier protein TusA family
A2U18_RS00360	COG1937	Protein conserved in bacteria
A2U18_RS00365	COG0730	response to heat
A2U18_RS00370	COG2217	Heavy metal translocating P-type atpase
A2U18_RS00375	COG1388	LysM domain
A2U18_RS00445	COG2814	Major facilitator Superfamily
A2U18_RS00470	COG0456	acetyltransferase
A2U18_RS00495	COG0655	NAD(P)H dehydrogenase (quinone) activity
A2U18_RS00510	COG1073	alpha beta
A2U18_RS00520	COG2226	methyltransferase
A2U18_RS00530	COG0823	Involved in the tonB-independent uptake of proteins
A2U18_RS00545	COG1473	amidohydrolase
A2U18_RS00555	COG1283	sodium-dependent phosphate transmembrane transporter activity
A2U18_RS00560	COG4716	Myosin-crossreactive antigen
A2U18_RS00570	COG1620	l-lactate permease
A2U18_RS00590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A2U18_RS00595	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A2U18_RS00600	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A2U18_RS00610	COG2423	ornithine cyclodeaminase activity
A2U18_RS00615	COG4264	IucA IucC family
A2U18_RS00620	COG2814	Major facilitator Superfamily
A2U18_RS00625	COG4264	IucA IucC family
A2U18_RS00630	COG4264	IucA IucC family
A2U18_RS00640	COG0019	diaminopimelate decarboxylase activity
A2U18_RS00645	COG1475	DNA binding
A2U18_RS00680	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A2U18_RS00685	COG0438	transferase activity, transferring glycosyl groups
A2U18_RS00715	COG0813	purine-nucleoside phosphorylase activity
A2U18_RS00720	COG2814	Major facilitator Superfamily
A2U18_RS00740	COG3639	organic phosphonate transmembrane transporter activity
A2U18_RS00760	COG0737	Belongs to the 5'-nucleotidase family
A2U18_RS00775	COG1012	belongs to the aldehyde dehydrogenase family
A2U18_RS00775	COG1454	alcohol dehydrogenase
A2U18_RS00800	COG1086	Polysaccharide biosynthesis protein
A2U18_RS00810	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A2U18_RS00840	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A2U18_RS00850	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A2U18_RS00855	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A2U18_RS00865	COG2832	Protein of unknown function (DUF454)
A2U18_RS00900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A2U18_RS00905	COG1960	acyl-CoA dehydrogenase activity
A2U18_RS00910	COG5609	conserved protein (DUF2294)
A2U18_RS00965	COG1309	transcriptional regulator
A2U18_RS00970	COG1114	Component of the transport system for branched-chain amino acids
A2U18_RS00975	COG1335	isochorismatase
A2U18_RS00980	COG3961	Belongs to the TPP enzyme family
A2U18_RS01010	COG1737	Transcriptional regulator
A2U18_RS01035	COG0601	transmembrane transport
A2U18_RS01040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A2U18_RS01050	COG0405	Gamma-glutamyltransferase
A2U18_RS01070	COG3842	ATPase activity
A2U18_RS01080	COG1175	transmembrane transport
A2U18_RS01085	COG3833	ABC-type maltose transport systems, permease component
A2U18_RS01090	COG0673	inositol 2-dehydrogenase activity
A2U18_RS01095	COG0673	inositol 2-dehydrogenase activity
A2U18_RS01105	COG1755	Isoprenylcysteine carboxyl methyltransferase
A2U18_RS01165	COG0183	Belongs to the thiolase family
A2U18_RS01175	COG1960	acyl-CoA dehydrogenase activity
A2U18_RS01180	COG0318	PFAM AMP-dependent synthetase and ligase
A2U18_RS01200	COG0747	negative chemotaxis
A2U18_RS01205	COG3189	MarR family transcriptional regulator
A2U18_RS01240	COG2190	(PTS) system
A2U18_RS01240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A2U18_RS01240	COG1263	PTS System
A2U18_RS01245	COG1957	nucleoside hydrolase
A2U18_RS01265	COG3414	Phosphotransferase system galactitol-specific IIB component
A2U18_RS01270	COG3775	system Galactitol-specific IIC component
A2U18_RS01275	COG1063	alcohol dehydrogenase
A2U18_RS01285	COG1063	alcohol dehydrogenase
A2U18_RS01295	COG1063	alcohol dehydrogenase
A2U18_RS01300	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A2U18_RS01310	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A2U18_RS01320	COG1063	alcohol dehydrogenase
A2U18_RS01325	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A2U18_RS01365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A2U18_RS01375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A2U18_RS01375	COG1263	PTS System
A2U18_RS01375	COG2190	(PTS) system
A2U18_RS01380	COG2723	6-phospho-beta-galactosidase activity
A2U18_RS01390	COG2226	methyltransferase
A2U18_RS01440	COG1131	(ABC) transporter
A2U18_RS01460	COG1388	LysM domain
A2U18_RS01460	COG3942	CHAP domain
A2U18_RS01570	COG1114	Component of the transport system for branched-chain amino acids
A2U18_RS01580	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
A2U18_RS01590	COG0577	efflux transmembrane transporter activity
A2U18_RS01620	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A2U18_RS01625	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A2U18_RS01650	COG3314	Sporulation integral membrane protein YlbJ
A2U18_RS01675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A2U18_RS01710	COG3037	sugar-specific permease SgaT UlaA
A2U18_RS01720	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A2U18_RS01725	COG3711	transcriptional antiterminator
A2U18_RS01750	COG2271	Major facilitator Superfamily
A2U18_RS01755	COG0346	lactoylglutathione lyase activity
A2U18_RS01760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A2U18_RS01765	COG0431	NADPH-dependent FMN reductase
A2U18_RS01780	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A2U18_RS01785	COG2822	iron ion transport
A2U18_RS01795	COG0672	)-iron permease
A2U18_RS01800	COG0805	protein transport
A2U18_RS01805	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A2U18_RS01815	COG1476	TRANSCRIPTIONal
A2U18_RS01825	COG1131	(ABC) transporter
A2U18_RS01855	COG0646	methionine synthase
A2U18_RS01855	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A2U18_RS01860	COG0626	cystathionine gamma-synthase activity
A2U18_RS01865	COG0626	cystathionine gamma-synthase activity
A2U18_RS01875	COG1475	DNA binding
A2U18_RS01880	COG0668	transmembrane transport
A2U18_RS01885	COG4481	Protein conserved in bacteria
A2U18_RS01890	COG0012	GTP binding
A2U18_RS01995	COG1823	symporter activity
A2U18_RS02030	COG2233	PERMEase
A2U18_RS02070	COG3759	membrane
A2U18_RS02215	COG0523	cobalamin synthesis protein
A2U18_RS02230	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A2U18_RS02240	COG5609	conserved protein (DUF2294)
A2U18_RS02255	COG1647	Serine aminopeptidase, S33
A2U18_RS02260	COG0733	neurotransmitter:sodium symporter activity
A2U18_RS02265	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A2U18_RS02270	COG0626	cystathionine gamma-synthase activity
A2U18_RS02280	COG2011	ABC-type metal ion transport system permease component
A2U18_RS02285	COG1464	Belongs to the NlpA lipoprotein family
A2U18_RS02320	COG0583	DNA-binding transcription factor activity
A2U18_RS02325	COG0067	glutamate synthase
A2U18_RS02325	COG0070	glutamate synthase
A2U18_RS02325	COG0069	glutamate synthase activity
A2U18_RS02330	COG0493	'glutamate synthase
A2U18_RS02345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A2U18_RS02345	COG1263	PTS System
A2U18_RS02350	COG0366	Alpha amylase catalytic
A2U18_RS02355	COG2188	Transcriptional regulator
A2U18_RS02375	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A2U18_RS02410	COG1982	Orn Lys Arg decarboxylase major
A2U18_RS02420	COG3870	Protein conserved in bacteria
A2U18_RS02425	COG0470	DNA polymerase III
A2U18_RS02430	COG1774	PSP1 C-terminal conserved region
A2U18_RS02440	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A2U18_RS02450	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A2U18_RS02460	COG0084	hydrolase, TatD family'
A2U18_RS02465	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
A2U18_RS02475	COG4466	Protein conserved in bacteria
A2U18_RS02485	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A2U18_RS02490	COG0251	oxidation-reduction process
A2U18_RS02535	COG2244	polysaccharide biosynthetic process
A2U18_RS02540	COG3956	TIGRFAM MazG family protein
A2U18_RS02545	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A2U18_RS02555	COG1098	S1 RNA binding domain
A2U18_RS02570	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A2U18_RS02595	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A2U18_RS02690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A2U18_RS02710	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A2U18_RS02720	COG3880	PFAM UvrB UvrC protein
A2U18_RS02735	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A2U18_RS02740	COG4956	integral membrane protein (PIN domain superfamily)
A2U18_RS02765	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
A2U18_RS02825	COG2813	Specifically methylates the guanine in position
A2U18_RS02865	COG1473	amidohydrolase
A2U18_RS02900	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A2U18_RS02905	COG1428	Deoxynucleoside kinase
A2U18_RS02910	COG1428	Deoxynucleoside kinase
A2U18_RS02920	COG0561	phosphatase activity
A2U18_RS02965	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A2U18_RS03080	COG0095	Lipoate-protein ligase
A2U18_RS03085	COG0083	homoserine kinase activity
A2U18_RS03105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A2U18_RS03185	COG0667	Aldo Keto reductase
A2U18_RS03190	COG0655	NAD(P)H dehydrogenase (quinone) activity
A2U18_RS03200	COG1078	dGTPase activity
A2U18_RS03235	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A2U18_RS03240	COG4139	cobalamin transport
A2U18_RS03335	COG0803	Belongs to the bacterial solute-binding protein 9 family
A2U18_RS03340	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A2U18_RS03345	COG1121	(ABC) transporter
A2U18_RS03350	COG1321	iron dependent repressor
A2U18_RS03360	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
A2U18_RS03370	COG1682	transport, permease protein
A2U18_RS03375	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A2U18_RS03385	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A2U18_RS03390	COG1686	Belongs to the peptidase S11 family
A2U18_RS03395	COG1132	(ABC) transporter
A2U18_RS03400	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A2U18_RS03410	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A2U18_RS03415	COG1120	ATPase activity
A2U18_RS03420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A2U18_RS03425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A2U18_RS03430	COG2376	Dihydroxyacetone kinase
A2U18_RS03450	COG3949	Membrane
A2U18_RS03475	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A2U18_RS03490	COG1136	(ABC) transporter
A2U18_RS03495	COG0577	efflux transmembrane transporter activity
A2U18_RS03500	COG1392	Phosphate transport regulator
A2U18_RS03505	COG0306	phosphate transporter
A2U18_RS03510	COG1388	LysM domain
A2U18_RS03510	COG3942	CHAP domain
A2U18_RS03520	COG4977	sequence-specific DNA binding
A2U18_RS03520	COG1917	Cupin 2, conserved barrel domain protein
A2U18_RS03550	COG0583	DNA-binding transcription factor activity
A2U18_RS03565	COG2814	Major facilitator Superfamily
A2U18_RS03570	COG2839	Protein conserved in bacteria
A2U18_RS03600	COG1611	Belongs to the LOG family
A2U18_RS03620	COG4988	ABC transporter
A2U18_RS03625	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A2U18_RS03635	COG0523	cobalamin synthesis protein
A2U18_RS03640	COG4989	oxidoreductase activity
A2U18_RS03650	COG0471	metal ion transport
A2U18_RS03655	COG0415	Belongs to the DNA photolyase family
A2U18_RS03685	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A2U18_RS03690	COG1349	DNA-binding transcription factor activity
A2U18_RS03695	COG1105	Belongs to the carbohydrate kinase PfkB family
A2U18_RS03700	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A2U18_RS03700	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A2U18_RS03700	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A2U18_RS03705	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A2U18_RS03710	COG1253	flavin adenine dinucleotide binding
A2U18_RS03715	COG0656	L-ascorbic acid biosynthetic process
A2U18_RS03720	COG0463	Glycosyl transferase, family 2
A2U18_RS03755	COG0720	synthase
A2U18_RS03765	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A2U18_RS03765	COG0512	Glutamine amidotransferase of anthranilate synthase
A2U18_RS03770	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A2U18_RS03800	COG0488	(ABC) transporter
A2U18_RS03805	COG0514	ATP-dependent DNA helicase (RecQ)
A2U18_RS03810	COG1125	glycine betaine transport
A2U18_RS03810	COG0517	IMP dehydrogenase activity
A2U18_RS03815	COG1174	glycine betaine transport
A2U18_RS03845	COG3104	oligopeptide transport
A2U18_RS03875	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A2U18_RS03880	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A2U18_RS03895	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A2U18_RS03900	COG4605	iron ion homeostasis
A2U18_RS03905	COG4604	ABC transporter, ATP-binding protein
A2U18_RS03910	COG4607	ABC-type enterochelin transport system periplasmic component
A2U18_RS03970	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A2U18_RS03975	COG1739	Uncharacterized protein family UPF0029
A2U18_RS03985	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
A2U18_RS03990	COG1040	competence protein
A2U18_RS04015	COG3942	CHAP domain
A2U18_RS04015	COG1388	LysM domain
A2U18_RS04085	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A2U18_RS04105	COG0281	malic enzyme
A2U18_RS04155	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A2U18_RS04160	COG1647	Serine aminopeptidase, S33
A2U18_RS04165	COG0557	exoribonuclease II activity
A2U18_RS04230	COG1278	Cold shock
A2U18_RS04270	COG0406	alpha-ribazole phosphatase activity
A2U18_RS04275	COG1279	arginine transmembrane transporter activity
A2U18_RS04300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A2U18_RS04305	COG1393	Belongs to the ArsC family
A2U18_RS04320	COG3878	Protein conserved in bacteria
A2U18_RS04330	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
A2U18_RS04345	COG2011	ABC-type metal ion transport system permease component
A2U18_RS04350	COG1464	Belongs to the NlpA lipoprotein family
A2U18_RS04365	COG0396	ATPase activity
A2U18_RS04370	COG0719	Fe-S assembly protein
A2U18_RS04380	COG0822	iron-sulfur transferase activity
A2U18_RS04400	COG1253	flavin adenine dinucleotide binding
A2U18_RS04410	COG1801	Protein of unknown function DUF72
A2U18_RS04415	COG0730	response to heat
A2U18_RS04430	COG4470	Protein conserved in bacteria
A2U18_RS04440	COG2445	Protein of unknown function DUF86
A2U18_RS04470	COG1696	Membrane protein involved in D-alanine export
A2U18_RS04480	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
A2U18_RS04485	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A2U18_RS04490	COG4837	Protein of unknown function (DUF1462)
A2U18_RS04495	COG1252	NADH dehydrogenase
A2U18_RS04505	COG0316	Belongs to the HesB IscA family
A2U18_RS04515	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A2U18_RS04520	COG2056	Na+-H+ antiporter family
A2U18_RS04525	COG2050	protein possibly involved in aromatic compounds catabolism
A2U18_RS04580	COG1098	S1 RNA binding domain
A2U18_RS04585	COG1902	pentaerythritol trinitrate reductase activity
A2U18_RS04610	COG0584	glycerophosphoryl diester phosphodiesterase
A2U18_RS04630	COG0398	Pfam SNARE associated Golgi protein
A2U18_RS04715	COG0741	lytic transglycosylase activity
A2U18_RS04715	COG0791	NLP P60 protein
A2U18_RS04745	COG2946	Replication initiation factor
A2U18_RS04755	COG1674	ftsk spoiiie
A2U18_RS04785	COG0561	phosphatase activity
A2U18_RS04810	COG1881	PFAM PEBP family protein
A2U18_RS04840	COG0601	transmembrane transport
A2U18_RS04845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A2U18_RS04850	COG0444	Belongs to the ABC transporter superfamily
A2U18_RS04855	COG4608	Belongs to the ABC transporter superfamily
A2U18_RS04860	COG4166	transmembrane transport
A2U18_RS04865	COG0601	transmembrane transport
A2U18_RS04870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A2U18_RS04875	COG0444	Belongs to the ABC transporter superfamily
A2U18_RS04880	COG4608	Belongs to the ABC transporter superfamily
A2U18_RS04885	COG4166	transmembrane transport
A2U18_RS04910	COG1164	Oligoendopeptidase f
A2U18_RS04920	COG2346	COG2346, Truncated hemoglobins
A2U18_RS04935	COG2357	RelA SpoT domain protein
A2U18_RS04945	COG0564	pseudouridine synthase activity
A2U18_RS04950	COG2239	Acts as a magnesium transporter
A2U18_RS04955	COG0475	glutathione-regulated potassium exporter activity
A2U18_RS04955	COG0569	domain protein
A2U18_RS04965	COG0628	permease
A2U18_RS05010	COG0861	Integral membrane protein TerC family
A2U18_RS05020	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A2U18_RS05025	COG0737	Belongs to the 5'-nucleotidase family
A2U18_RS05040	COG4903	ComK protein
A2U18_RS05055	COG4873	Protein conserved in bacteria
A2U18_RS05105	COG3682	Transcriptional regulator
A2U18_RS05135	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
A2U18_RS05145	COG2314	TM2 domain
A2U18_RS05150	COG0456	acetyltransferase
A2U18_RS05155	COG1575	Belongs to the MenA family. Type 1 subfamily
A2U18_RS05165	COG1169	isochorismate synthase
A2U18_RS05205	COG0436	Aminotransferase
A2U18_RS05210	COG3594	Acyltransferase
A2U18_RS05240	COG1316	TRANSCRIPTIONal
A2U18_RS05290	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A2U18_RS05305	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A2U18_RS05350	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A2U18_RS05355	COG4172	Belongs to the ABC transporter superfamily
A2U18_RS05360	COG4721	ABC-type cobalt transport system, permease component
A2U18_RS05385	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A2U18_RS05410	COG1271	oxidase subunit
A2U18_RS05415	COG1294	oxidase, subunit
A2U18_RS05420	COG0569	domain protein
A2U18_RS05490	COG1176	ABC-type spermidine putrescine transport system, permease component I
A2U18_RS05495	COG1177	transmembrane transport
A2U18_RS05500	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A2U18_RS05525	COG0483	inositol monophosphate 1-phosphatase activity
A2U18_RS05535	COG1217	gtp-binding protein TYPA
A2U18_RS05545	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A2U18_RS05555	COG0772	Belongs to the SEDS family
A2U18_RS05590	COG3679	Belongs to the UPF0342 family
A2U18_RS05595	COG0584	glycerophosphoryl diester phosphodiesterase
A2U18_RS05610	COG0742	ribosomal rna small subunit methyltransferase
A2U18_RS05670	COG4509	Sortase family
A2U18_RS05685	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A2U18_RS05720	COG1796	DNA polymerase
A2U18_RS05720	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A2U18_RS05745	COG2009	succinate dehydrogenase
A2U18_RS05750	COG1053	succinate dehydrogenase
A2U18_RS05755	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A2U18_RS05810	COG2801	Transposase and inactivated derivatives
A2U18_RS05880	COG1288	antiporter activity
A2U18_RS05915	COG1011	Hydrolase
A2U18_RS05940	COG4839	cell division protein FtsL
A2U18_RS05945	COG0768	penicillin binding
A2U18_RS05960	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A2U18_RS05965	COG0849	cell division
A2U18_RS05980	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A2U18_RS05990	COG0762	integral membrane protein
A2U18_RS05995	COG2302	S4 RNA-binding domain
A2U18_RS06000	COG3599	regulation of cell shape
A2U18_RS06010	COG2826	transposase and inactivated derivatives, IS30 family
A2U18_RS06015	COG2514	catechol 2,3-dioxygenase activity
A2U18_RS06025	COG0564	pseudouridine synthase activity
A2U18_RS06035	COG2233	PERMEase
A2U18_RS06080	COG1293	RNA-binding protein homologous to eukaryotic snRNP
A2U18_RS06095	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A2U18_RS06100	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A2U18_RS06110	COG2314	TM2 domain
A2U18_RS06125	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A2U18_RS06125	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A2U18_RS06135	COG0631	protein serine/threonine phosphatase activity
A2U18_RS06150	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A2U18_RS06165	COG1302	Protein conserved in bacteria
A2U18_RS06215	COG1196	nuclear chromosome segregation
A2U18_RS06220	COG0552	protein localization to endoplasmic reticulum
A2U18_RS06230	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A2U18_RS06295	COG0758	DNA mediated transformation
A2U18_RS06395	COG0195	Participates in both transcription termination and antitermination
A2U18_RS06400	COG2740	Nucleic-acid-binding protein implicated in transcription termination
A2U18_RS06425	COG0196	riboflavin kinase activity
A2U18_RS06455	COG2188	Transcriptional regulator
A2U18_RS06460	COG0612	Peptidase, M16
A2U18_RS06465	COG0612	Peptidase, M16
A2U18_RS06470	COG0300	oxidoreductase activity
A2U18_RS06490	COG1546	Belongs to the CinA family
A2U18_RS06490	COG1058	Belongs to the CinA family
A2U18_RS06510	COG1692	metallophosphoesterase
A2U18_RS06515	COG0674	pyruvate-flavodoxin oxidoreductase activity
A2U18_RS06515	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A2U18_RS06520	COG1013	pyruvate-flavodoxin oxidoreductase activity
A2U18_RS06525	COG2826	transposase and inactivated derivatives, IS30 family
A2U18_RS06560	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
A2U18_RS06565	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A2U18_RS06590	COG1923	regulation of RNA biosynthetic process
A2U18_RS06600	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A2U18_RS06605	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
A2U18_RS06610	COG0789	Transcriptional regulator
A2U18_RS06695	COG1525	nuclease
A2U18_RS06710	COG0527	aspartate kinase activity
A2U18_RS06715	COG0460	homoserine dehydrogenase
A2U18_RS06720	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A2U18_RS06745	COG0833	amino acid
A2U18_RS06775	COG2340	Cysteine-rich secretory protein family
A2U18_RS06810	COG4846	Membrane protein involved in cytochrome C biogenesis
A2U18_RS06830	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A2U18_RS06845	COG0824	Thioesterase
A2U18_RS06875	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A2U18_RS06885	COG1115	amino acid carrier protein
A2U18_RS06900	COG0628	permease
A2U18_RS06925	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A2U18_RS06935	COG1363	Peptidase, m42
A2U18_RS06940	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A2U18_RS06945	COG0512	Glutamine amidotransferase of anthranilate synthase
A2U18_RS06985	COG0561	phosphatase activity
A2U18_RS07035	COG0704	Plays a role in the regulation of phosphate uptake
A2U18_RS07045	COG0581	inorganic phosphate transmembrane transporter activity
A2U18_RS07050	COG0573	inorganic phosphate transmembrane transporter activity
A2U18_RS07070	COG0488	(ABC) transporter
A2U18_RS07080	COG0527	aspartate kinase activity
A2U18_RS07085	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A2U18_RS07120	COG2808	Putative FMN-binding domain
A2U18_RS07165	COG4548	von Willebrand factor, type A
A2U18_RS07170	COG0714	Associated with various cellular activities
A2U18_RS07215	COG0671	phosphoesterase, PA-phosphatase related
A2U18_RS07290	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A2U18_RS07310	COG0531	amino acid
A2U18_RS07325	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A2U18_RS07330	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A2U18_RS07345	COG0116	Belongs to the methyltransferase superfamily
A2U18_RS07380	COG4499	WXG100 protein secretion system (Wss), protein YukC
A2U18_RS07380	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A2U18_RS07390	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A2U18_RS07395	COG3935	DnaD domain protein
A2U18_RS07420	COG0438	transferase activity, transferring glycosyl groups
A2U18_RS07425	COG1694	Mazg nucleotide pyrophosphohydrolase
A2U18_RS07430	COG2738	Putative neutral zinc metallopeptidase
A2U18_RS07435	COG4347	Protein of unknown function (DUF1405)
A2U18_RS07475	COG0142	geranyltranstransferase activity
A2U18_RS07540	COG0492	ferredoxin-NADP+ reductase activity
A2U18_RS07555	COG0514	ATP-dependent DNA helicase (RecQ)
A2U18_RS07565	COG1141	Ferredoxin
A2U18_RS07610	COG1388	LysM domain
A2U18_RS07610	COG0860	N-Acetylmuramoyl-L-alanine amidase
A2U18_RS07660	COG3953	SLT domain
A2U18_RS07660	COG5280	Phage tail tape measure protein TP901
A2U18_RS07950	COG0582	viral genome integration into host DNA
A2U18_RS07965	COG5002	protein histidine kinase activity
A2U18_RS07970	COG0745	RESPONSE REGULATOR receiver
A2U18_RS07975	COG1187	pseudouridine synthase activity
A2U18_RS08000	COG0735	belongs to the Fur family
A2U18_RS08005	COG0494	nUDIX hydrolase
A2U18_RS08010	COG0667	Aldo Keto reductase
A2U18_RS08035	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A2U18_RS08045	COG0366	Alpha amylase catalytic
A2U18_RS08050	COG1609	Transcriptional regulator
A2U18_RS08070	COG2195	Cleaves the N-terminal amino acid of tripeptides
A2U18_RS08080	COG4129	membrane
A2U18_RS08090	COG0508	dehydrogenase complex catalyzes the overall conversion of
A2U18_RS08095	COG0022	dehydrogenase e1 component
A2U18_RS08100	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A2U18_RS08105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A2U18_RS08110	COG0497	DNA recombination
A2U18_RS08140	COG1302	Protein conserved in bacteria
A2U18_RS08145	COG0439	Biotin carboxylase
A2U18_RS08150	COG0511	ligase activity, forming carbon-carbon bonds
A2U18_RS08160	COG0006	proline dipeptidase activity
A2U18_RS08175	COG0095	Lipoate-protein ligase
A2U18_RS08180	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A2U18_RS08225	COG4537	Required for transformation and DNA binding
A2U18_RS08230	COG1459	type II secretion system
A2U18_RS08235	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A2U18_RS08240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A2U18_RS08245	COG0011	TIGRFAM Protein of
A2U18_RS08250	COG1940	carbohydrate kinase activity
A2U18_RS08255	COG4483	Protein conserved in bacteria
A2U18_RS08265	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A2U18_RS08275	COG0768	penicillin binding
A2U18_RS08290	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A2U18_RS08295	COG1121	(ABC) transporter
A2U18_RS08305	COG0513	Belongs to the DEAD box helicase family
A2U18_RS08315	COG2384	SAM-dependent methyltransferase
A2U18_RS08335	COG0517	IMP dehydrogenase activity
A2U18_RS08355	COG0295	cytidine deaminase activity
A2U18_RS08370	COG1702	phosphate starvation-inducible protein PhoH
A2U18_RS08385	COG1030	water channel activity
A2U18_RS08395	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A2U18_RS08400	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A2U18_RS08430	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A2U18_RS08450	COG1466	dna polymerase III delta subunit
A2U18_RS08455	COG2333	competence protein COMEC
A2U18_RS08455	COG0658	competence protein
A2U18_RS08460	COG2131	deaminase
A2U18_RS08470	COG2226	methyltransferase
A2U18_RS08475	COG0799	negative regulation of ribosome biogenesis
A2U18_RS08480	COG1713	HD superfamily hydrolase involved in NAD metabolism
A2U18_RS08490	COG1534	Rna-binding protein
A2U18_RS08500	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A2U18_RS08505	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
A2U18_RS08525	COG3177	Filamentation induced by cAMP protein fic
A2U18_RS08530	COG1914	H( )-stimulated, divalent metal cation uptake system
A2U18_RS08540	COG0439	Biotin carboxylase
A2U18_RS08545	COG0511	ligase activity, forming carbon-carbon bonds
A2U18_RS08550	COG1984	allophanate hydrolase subunit 2
A2U18_RS08555	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A2U18_RS08570	COG0826	peptidase U32
A2U18_RS08575	COG0826	peptidase U32
A2U18_RS08605	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A2U18_RS08625	COG1104	cysteine desulfurase activity
A2U18_RS08630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A2U18_RS08640	COG3237	CsbD-like
A2U18_RS08645	COG1959	2 iron, 2 sulfur cluster binding
A2U18_RS08650	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A2U18_RS08655	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A2U18_RS08700	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A2U18_RS08700	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A2U18_RS08705	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A2U18_RS08705	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A2U18_RS08710	COG1862	Preprotein translocase
A2U18_RS08750	COG2868	ribosomal protein
A2U18_RS08795	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A2U18_RS08830	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A2U18_RS08840	COG0285	dihydrofolate synthase activity
A2U18_RS08850	COG2818	Glycosylase
A2U18_RS08885	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A2U18_RS08920	COG4112	unkown
A2U18_RS08945	COG0833	amino acid
A2U18_RS08960	COG1484	DNA-dependent DNA replication
A2U18_RS08990	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A2U18_RS08990	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A2U18_RS09000	COG5002	protein histidine kinase activity
A2U18_RS09005	COG0745	RESPONSE REGULATOR receiver
A2U18_RS09020	COG0372	Belongs to the citrate synthase family
A2U18_RS09025	COG1113	amino acid transport
A2U18_RS09050	COG0281	malic enzyme
A2U18_RS09060	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A2U18_RS09070	COG4109	DRTGG domain
A2U18_RS09110	COG0827	DNA restriction-modification system
A2U18_RS09120	COG0730	response to heat
A2U18_RS09130	COG1104	cysteine desulfurase activity
A2U18_RS09140	COG1956	GAF domain-containing protein
A2U18_RS09160	COG0584	glycerophosphoryl diester phosphodiesterase
A2U18_RS09165	COG1764	response to oxidative stress
A2U18_RS09170	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A2U18_RS09175	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A2U18_RS09200	COG0204	Acyl-transferase
A2U18_RS09205	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A2U18_RS09225	COG5386	Cell surface protein
A2U18_RS09240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A2U18_RS09245	COG0454	-acetyltransferase
A2U18_RS09265	COG1605	Chorismate mutase
A2U18_RS09265	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A2U18_RS09290	COG1674	ftsk spoiiie
A2U18_RS09295	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A2U18_RS09305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A2U18_RS09310	COG1363	Peptidase, m42
A2U18_RS09320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A2U18_RS09330	COG0510	thiamine kinase activity
A2U18_RS09350	COG1187	pseudouridine synthase activity
A2U18_RS09355	COG2244	polysaccharide biosynthetic process
A2U18_RS09360	COG2081	HI0933 family
A2U18_RS09380	COG2814	Major facilitator Superfamily
A2U18_RS09385	COG1242	4 iron, 4 sulfur cluster binding
A2U18_RS09390	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A2U18_RS09400	COG2267	carboxylic ester hydrolase activity
A2U18_RS09435	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A2U18_RS09435	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A2U18_RS09455	COG3266	domain, Protein
A2U18_RS09455	COG4193	domain, Protein
A2U18_RS09455	COG5632	N-Acetylmuramoyl-L-alanine amidase
A2U18_RS09495	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A2U18_RS09515	COG0656	L-ascorbic acid biosynthetic process
A2U18_RS09535	COG1506	peptidase
A2U18_RS09540	COG2816	NAD+ diphosphatase activity
A2U18_RS09630	COG5492	domain, Protein
A2U18_RS09690	COG5632	N-Acetylmuramoyl-L-alanine amidase
A2U18_RS09690	COG1388	LysM domain
A2U18_RS09925	COG0305	Participates in initiation and elongation during chromosome replication
A2U18_RS10070	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
A2U18_RS10100	COG1131	(ABC) transporter
A2U18_RS10105	COG0537	adenosine 5'-monophosphoramidase activity
A2U18_RS10135	COG0420	3'-5' exonuclease activity
A2U18_RS10165	COG2197	response regulator
A2U18_RS10170	COG2203	Gaf domain
A2U18_RS10170	COG4585	Histidine kinase
A2U18_RS10175	COG0564	pseudouridine synthase activity
A2U18_RS10210	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A2U18_RS10215	COG1126	abc transporter atp-binding protein
A2U18_RS10220	COG0765	amino acid transport
A2U18_RS10385	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A2U18_RS10390	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A2U18_RS10400	COG4129	membrane
A2U18_RS10420	COG1194	a g-specific adenine glycosylase
A2U18_RS10425	COG1988	membrane-bound metal-dependent
A2U18_RS10440	COG1134	teichoic acid transport
A2U18_RS10440	COG1388	LysM domain
A2U18_RS10470	COG0535	radical SAM domain protein
A2U18_RS10475	COG1607	acyl-coa hydrolase
A2U18_RS10480	COG2309	aminopeptidase activity
A2U18_RS10500	COG1295	ribonuclease BN
A2U18_RS10620	COG4851	CamS sex pheromone cAM373 precursor
A2U18_RS10640	COG4496	protein, YerC YecD
A2U18_RS10675	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A2U18_RS10685	COG0077	Prephenate dehydratase
A2U18_RS10705	COG1335	isochorismatase
A2U18_RS10720	COG1012	belongs to the aldehyde dehydrogenase family
A2U18_RS10770	COG1131	(ABC) transporter
A2U18_RS10785	COG1725	Transcriptional regulator
A2U18_RS10830	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A2U18_RS10910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A2U18_RS10915	COG1621	beta-fructofuranosidase activity
A2U18_RS10920	COG1609	Transcriptional regulator
A2U18_RS10925	COG0004	ammonium transporteR
A2U18_RS10930	COG0425	Belongs to the sulfur carrier protein TusA family
A2U18_RS10935	COG2391	methyltransferase activity
A2U18_RS10945	COG0488	(ABC) transporter
A2U18_RS10955	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A2U18_RS10965	COG0456	acetyltransferase
A2U18_RS10970	COG1214	PFAM Peptidase M22, glycoprotease
A2U18_RS10975	COG0802	atpase or kinase
A2U18_RS10990	COG0028	Belongs to the TPP enzyme family
A2U18_RS11065	COG2183	response to ionizing radiation
A2U18_RS11070	COG1191	sigma factor activity
A2U18_RS11080	COG1366	Belongs to the anti-sigma-factor antagonist family
A2U18_RS11085	COG2208	phosphoserine phosphatase activity
A2U18_RS11120	COG3428	Bacterial PH domain
A2U18_RS11150	COG2205	protein histidine kinase activity
A2U18_RS11155	COG0745	RESPONSE REGULATOR receiver
A2U18_RS11165	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A2U18_RS11175	COG0772	Belongs to the SEDS family
A2U18_RS11190	COG1937	Protein conserved in bacteria
A2U18_RS11200	COG1418	mRNA catabolic process
A2U18_RS11245	COG0629	single-stranded DNA binding
A2U18_RS11325	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A2U18_RS11350	COG0009	L-threonylcarbamoyladenylate synthase
A2U18_RS11355	COG2890	protein-(glutamine-N5) methyltransferase activity
A2U18_RS11380	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A2U18_RS11420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A2U18_RS11470	COG0813	purine-nucleoside phosphorylase activity
A2U18_RS11475	COG0783	Belongs to the Dps family
A2U18_RS11495	COG1482	cell wall glycoprotein biosynthetic process
A2U18_RS11500	COG0702	epimerase
A2U18_RS11505	COG0640	Transcriptional regulator
A2U18_RS11540	COG0561	phosphatase activity
A2U18_RS11545	COG1119	ATPase activity
A2U18_RS11570	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A2U18_RS11635	COG3711	transcriptional antiterminator
A2U18_RS11665	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A2U18_RS11725	COG0489	protein tyrosine kinase activity
A2U18_RS11730	COG2814	Major facilitator Superfamily
A2U18_RS11745	COG1272	protein, Hemolysin III
A2U18_RS11755	COG1988	membrane-bound metal-dependent
A2U18_RS11765	COG3314	Sporulation integral membrane protein YlbJ
A2U18_RS11770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A2U18_RS11775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A2U18_RS11780	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
A2U18_RS11790	COG3457	Alanine racemase
A2U18_RS11795	COG4264	IucA IucC family
A2U18_RS11800	COG2814	Major facilitator Superfamily
A2U18_RS11825	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A2U18_RS11835	COG2130	NADP-dependent
A2U18_RS11900	COG0656	L-ascorbic acid biosynthetic process
A2U18_RS11905	COG0789	Transcriptional regulator
A2U18_RS11915	COG5492	domain, Protein
A2U18_RS11930	COG0438	transferase activity, transferring glycosyl groups
A2U18_RS11945	COG3527	Alpha-acetolactate decarboxylase
A2U18_RS11950	COG0028	Belongs to the TPP enzyme family
A2U18_RS11960	COG2826	transposase and inactivated derivatives, IS30 family
A2U18_RS12035	COG0201	protein transport
A2U18_RS12150	COG2252	PERMEase
A2U18_RS12195	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A2U18_RS12260	COG1763	Mo-molybdopterin cofactor biosynthetic process
A2U18_RS12280	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A2U18_RS12285	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A2U18_RS12290	COG4149	molybdate abc transporter
A2U18_RS12295	COG0725	ABC transporter, periplasmic molybdate-binding protein
A2U18_RS12310	COG1268	BioY protein
A2U18_RS12325	COG1960	acyl-CoA dehydrogenase activity
A2U18_RS12330	COG4413	Urea transporter
A2U18_RS12405	COG1757	Na H antiporter
A2U18_RS12420	COG3942	CHAP domain
A2U18_RS12485	COG1266	CAAX protease self-immunity
A2U18_RS12500	COG1113	amino acid transport
A2U18_RS12520	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A2U18_RS12525	COG0385	Bile acid
A2U18_RS12535	COG1263	PTS System
A2U18_RS12535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A2U18_RS12540	COG1737	Transcriptional regulator
A2U18_RS12560	COG1028	Short-chain dehydrogenase reductase Sdr
A2U18_RS12565	COG1473	amidohydrolase
A2U18_RS12580	COG0583	DNA-binding transcription factor activity
A2U18_RS12600	COG2258	MOSC domain
A2U18_RS12620	COG1668	transmembrane transport
A2U18_RS12625	COG4152	abc transporter atp-binding protein
A2U18_RS12630	COG3152	Membrane
A2U18_RS12645	COG0786	glutamate:sodium symporter activity
A2U18_RS12655	COG0598	Magnesium transport protein CorA
A2U18_RS12670	COG0657	acetylesterase activity
A2U18_RS12680	COG2814	Major facilitator Superfamily
A2U18_RS12685	COG1566	PFAM secretion protein HlyD family protein
A2U18_RS12700	COG2814	Major facilitator Superfamily
A2U18_RS12765	COG1620	l-lactate permease
A2U18_RS12775	COG2826	transposase and inactivated derivatives, IS30 family
A2U18_RS12790	COG0604	alcohol dehydrogenase
A2U18_RS12820	COG1511	domain protein
A2U18_RS12835	COG1263	PTS System
A2U18_RS12835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A2U18_RS12850	COG3871	stress protein (general stress protein 26)
A2U18_RS12895	COG0789	Transcriptional regulator
A2U18_RS12915	COG2181	nitrate reductase activity
A2U18_RS12925	COG1140	nitrate reductase beta subunit
A2U18_RS12930	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
A2U18_RS12940	COG2146	nitrite reductase [NAD(P)H] activity
A2U18_RS12945	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A2U18_RS12955	COG0454	-acetyltransferase
A2U18_RS12965	COG2116	formate transmembrane transporter activity
A2U18_RS12980	COG0803	Belongs to the bacterial solute-binding protein 9 family
A2U18_RS12980	COG3443	Belongs to the bacterial solute-binding protein 9 family
A2U18_RS13005	COG1126	abc transporter atp-binding protein
A2U18_RS13010	COG0765	amino acid transport
A2U18_RS13015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A2U18_RS13020	COG2814	Major facilitator Superfamily
A2U18_RS13040	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A2U18_RS13090	COG0156	8-amino-7-oxononanoate synthase activity
A2U18_RS13100	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A2U18_RS13105	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A2U18_RS13120	COG1132	(ABC) transporter
A2U18_RS13125	COG1132	(ABC) transporter
A2U18_RS13125	COG2375	cellular response to nickel ion
A2U18_RS13145	COG1929	Belongs to the glycerate kinase type-1 family
A2U18_RS13155	COG2814	Major facilitator Superfamily
A2U18_RS13175	COG1113	amino acid transport
A2U18_RS13185	COG0531	amino acid
A2U18_RS13205	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A2U18_RS13215	COG1174	glycine betaine transport
A2U18_RS13225	COG1174	glycine betaine transport
A2U18_RS13240	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
A2U18_RS13245	COG0531	amino acid
A2U18_RS13250	COG2272	Belongs to the type-B carboxylesterase lipase family
A2U18_RS13255	COG2814	Major facilitator Superfamily
A2U18_RS13260	COG0390	transport system, permease component
A2U18_RS13265	COG4619	ABC transporter
A2U18_RS13270	COG1363	Peptidase, m42
A2U18_RS13275	COG4808	Protein conserved in bacteria
A2U18_RS13280	COG0069	glutamate synthase activity
A2U18_RS13295	COG1124	(ABC) transporter
A2U18_RS13305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A2U18_RS13310	COG0601	transmembrane transport
A2U18_RS13315	COG0747	negative chemotaxis
A2U18_RS13340	COG1028	Short-chain dehydrogenase reductase Sdr
A2U18_RS13345	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A2U18_RS13350	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A2U18_RS13500	COG1070	Carbohydrate kinase
A2U18_RS13505	COG1802	Transcriptional regulator
A2U18_RS13510	COG0789	Transcriptional regulator
A2U18_RS13515	COG2357	RelA SpoT domain protein
A2U18_RS13520	COG4876	unkown
A2U18_RS13535	COG2271	Major facilitator Superfamily
A2U18_RS13540	COG0586	Pfam SNARE associated Golgi protein
A2U18_RS13550	COG2814	Major facilitator Superfamily
A2U18_RS13555	COG1846	Transcriptional regulator
A2U18_RS13565	COG1131	(ABC) transporter
A2U18_RS13585	COG0400	carboxylic ester hydrolase activity
A2U18_RS13590	COG0346	lactoylglutathione lyase activity
A2U18_RS13595	COG1846	Transcriptional regulator
A2U18_RS13605	COG2514	catechol 2,3-dioxygenase activity
A2U18_RS13620	COG0561	phosphatase activity
A2U18_RS13625	COG3764	Sortase (surface protein transpeptidase)
A2U18_RS13645	COG1760	l-serine dehydratase
A2U18_RS13650	COG1760	l-serine dehydratase
A2U18_RS13665	COG0697	spore germination
A2U18_RS13670	COG0657	acetylesterase activity
A2U18_RS13690	COG0028	Belongs to the TPP enzyme family
A2U18_RS13705	COG0583	DNA-binding transcription factor activity
A2U18_RS13715	COG3942	CHAP domain
A2U18_RS13725	COG3425	synthase
A2U18_RS13730	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A2U18_RS13755	COG2409	Drug exporters of the RND superfamily
A2U18_RS13800	COG0436	Aminotransferase
A2U18_RS13900	COG0596	Alpha beta hydrolase
A2U18_RS13935	COG3001	Fructosamine kinase
A2U18_RS13940	COG0167	dihydroorotate dehydrogenase activity
A2U18_RS13990	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A2U18_RS13995	COG3527	Alpha-acetolactate decarboxylase
A2U18_RS14010	COG0531	amino acid
A2U18_RS14040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A2U18_RS14060	COG1012	belongs to the aldehyde dehydrogenase family
A2U18_RS14070	COG1510	regulation of RNA biosynthetic process
A2U18_RS14075	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A2U18_RS14100	COG2851	Citrate transporter
A2U18_RS14115	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A2U18_RS14125	COG0386	Belongs to the glutathione peroxidase family
A2U18_RS14150	COG1136	(ABC) transporter
A2U18_RS14155	COG2205	protein histidine kinase activity
A2U18_RS14160	COG0745	RESPONSE REGULATOR receiver
A2U18_RS14170	COG1785	Belongs to the alkaline phosphatase family
A2U18_RS14180	COG1846	Transcriptional regulator
A2U18_RS14225	COG1438	arginine binding
A2U18_RS14245	COG3711	transcriptional antiterminator
A2U18_RS14245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A2U18_RS14250	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A2U18_RS14250	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A2U18_RS14250	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A2U18_RS14255	COG1482	cell wall glycoprotein biosynthetic process
A2U18_RS14265	COG1705	Flagellar rod assembly protein muramidase FlgJ
A2U18_RS14265	COG3942	CHAP domain
A2U18_RS14270	COG3433	isochorismatase activity
A2U18_RS14270	COG1535	isochorismatase
A2U18_RS14285	COG0438	transferase activity, transferring glycosyl groups
A2U18_RS14300	COG1073	alpha beta
A2U18_RS14320	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A2U18_RS14350	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A2U18_RS14445	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A2U18_RS14515	COG0471	metal ion transport
A2U18_RS14520	COG2962	Rard protein
A2U18_RS14530	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
A2U18_RS14545	COG1136	(ABC) transporter
A2U18_RS14550	COG0577	efflux transmembrane transporter activity
A2U18_RS14560	COG1278	Cold shock
A2U18_RS14580	COG1475	DNA binding