locus-tag	class	description
M013TW_RS00020	COG2501	S4 domain
M013TW_RS00040	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M013TW_RS00065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M013TW_RS00075	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
M013TW_RS00085	COG0305	Participates in initiation and elongation during chromosome replication
M013TW_RS00115	COG4863	YycH protein
M013TW_RS00125	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
M013TW_RS00130	COG0737	Belongs to the 5'-nucleotidase family
M013TW_RS00155	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M013TW_RS00155	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M013TW_RS00200	COG0584	glycerophosphoryl diester phosphodiesterase
M013TW_RS00205	COG2030	dehydratase
M013TW_RS00240	COG2801	Transposase and inactivated derivatives
M013TW_RS00265	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M013TW_RS00290	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
M013TW_RS00300	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
M013TW_RS00305	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M013TW_RS00310	COG0210	DNA helicase
M013TW_RS00320	COG0076	glutamate decarboxylase activity
M013TW_RS00350	COG1522	sequence-specific DNA binding
M013TW_RS00355	COG0456	acetyltransferase
M013TW_RS00380	COG0655	NAD(P)H dehydrogenase (quinone) activity
M013TW_RS00415	COG0823	Involved in the tonB-independent uptake of proteins
M013TW_RS00430	COG1473	amidohydrolase
M013TW_RS00440	COG1283	sodium-dependent phosphate transmembrane transporter activity
M013TW_RS00445	COG4716	Myosin-crossreactive antigen
M013TW_RS00450	COG0697	spore germination
M013TW_RS00465	COG1620	l-lactate permease
M013TW_RS00485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M013TW_RS00490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M013TW_RS00495	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M013TW_RS00505	COG2423	ornithine cyclodeaminase activity
M013TW_RS00510	COG4264	IucA IucC family
M013TW_RS00515	COG2814	Major facilitator Superfamily
M013TW_RS00520	COG4264	IucA IucC family
M013TW_RS00525	COG4264	IucA IucC family
M013TW_RS00535	COG0019	diaminopimelate decarboxylase activity
M013TW_RS00540	COG1475	DNA binding
M013TW_RS00570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M013TW_RS00575	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M013TW_RS00580	COG0438	transferase activity, transferring glycosyl groups
M013TW_RS00615	COG0813	purine-nucleoside phosphorylase activity
M013TW_RS00620	COG2814	Major facilitator Superfamily
M013TW_RS00640	COG3639	organic phosphonate transmembrane transporter activity
M013TW_RS00660	COG0737	Belongs to the 5'-nucleotidase family
M013TW_RS00675	COG1454	alcohol dehydrogenase
M013TW_RS00675	COG1012	belongs to the aldehyde dehydrogenase family
M013TW_RS00700	COG1086	Polysaccharide biosynthesis protein
M013TW_RS00710	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M013TW_RS00740	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M013TW_RS00750	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M013TW_RS00755	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M013TW_RS00765	COG2832	Protein of unknown function (DUF454)
M013TW_RS00800	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M013TW_RS00805	COG1960	acyl-CoA dehydrogenase activity
M013TW_RS00825	COG3477	response to acidic pH
M013TW_RS00850	COG1114	Component of the transport system for branched-chain amino acids
M013TW_RS00855	COG1335	isochorismatase
M013TW_RS00860	COG3961	Belongs to the TPP enzyme family
M013TW_RS00885	COG1737	Transcriptional regulator
M013TW_RS00910	COG0601	transmembrane transport
M013TW_RS00915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M013TW_RS00925	COG0405	Gamma-glutamyltransferase
M013TW_RS00945	COG3842	ATPase activity
M013TW_RS00955	COG1175	transmembrane transport
M013TW_RS00960	COG3833	ABC-type maltose transport systems, permease component
M013TW_RS00965	COG0673	inositol 2-dehydrogenase activity
M013TW_RS00970	COG0673	inositol 2-dehydrogenase activity
M013TW_RS00980	COG1755	Isoprenylcysteine carboxyl methyltransferase
M013TW_RS01040	COG0183	Belongs to the thiolase family
M013TW_RS01050	COG1960	acyl-CoA dehydrogenase activity
M013TW_RS01055	COG0318	PFAM AMP-dependent synthetase and ligase
M013TW_RS01070	COG0747	negative chemotaxis
M013TW_RS01075	COG3189	MarR family transcriptional regulator
M013TW_RS01105	COG2190	(PTS) system
M013TW_RS01105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M013TW_RS01105	COG1263	PTS System
M013TW_RS01110	COG1957	nucleoside hydrolase
M013TW_RS01130	COG3414	Phosphotransferase system galactitol-specific IIB component
M013TW_RS01135	COG3775	system Galactitol-specific IIC component
M013TW_RS01140	COG1063	alcohol dehydrogenase
M013TW_RS01150	COG1063	alcohol dehydrogenase
M013TW_RS01160	COG1063	alcohol dehydrogenase
M013TW_RS01165	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M013TW_RS01170	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M013TW_RS01180	COG1063	alcohol dehydrogenase
M013TW_RS01185	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M013TW_RS01220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M013TW_RS01225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M013TW_RS01225	COG2190	(PTS) system
M013TW_RS01225	COG1263	PTS System
M013TW_RS01230	COG2723	6-phospho-beta-galactosidase activity
M013TW_RS01235	COG2226	methyltransferase
M013TW_RS01290	COG1131	(ABC) transporter
M013TW_RS01310	COG1388	LysM domain
M013TW_RS01310	COG3942	CHAP domain
M013TW_RS01435	COG1114	Component of the transport system for branched-chain amino acids
M013TW_RS01440	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
M013TW_RS01450	COG0577	efflux transmembrane transporter activity
M013TW_RS01475	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M013TW_RS01480	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M013TW_RS01505	COG3314	Sporulation integral membrane protein YlbJ
M013TW_RS01530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M013TW_RS01555	COG3037	sugar-specific permease SgaT UlaA
M013TW_RS01565	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M013TW_RS01570	COG3711	transcriptional antiterminator
M013TW_RS01590	COG2271	Major facilitator Superfamily
M013TW_RS01595	COG0346	lactoylglutathione lyase activity
M013TW_RS01600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M013TW_RS01605	COG0431	NADPH-dependent FMN reductase
M013TW_RS01620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M013TW_RS01625	COG2822	iron ion transport
M013TW_RS01635	COG0672	)-iron permease
M013TW_RS01640	COG0805	protein transport
M013TW_RS01645	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M013TW_RS01655	COG1476	TRANSCRIPTIONal
M013TW_RS01665	COG1131	(ABC) transporter
M013TW_RS01700	COG0646	methionine synthase
M013TW_RS01700	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M013TW_RS01705	COG0626	cystathionine gamma-synthase activity
M013TW_RS01710	COG0626	cystathionine gamma-synthase activity
M013TW_RS01715	COG1475	DNA binding
M013TW_RS01720	COG0668	transmembrane transport
M013TW_RS01725	COG4481	Protein conserved in bacteria
M013TW_RS01730	COG0012	GTP binding
M013TW_RS01770	COG0582	viral genome integration into host DNA
M013TW_RS01840	COG1823	symporter activity
M013TW_RS01870	COG2233	PERMEase
M013TW_RS01930	COG1683	Conserved Protein
M013TW_RS01940	COG3759	membrane
M013TW_RS02105	COG0523	cobalamin synthesis protein
M013TW_RS02115	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M013TW_RS02130	COG5609	conserved protein (DUF2294)
M013TW_RS02145	COG1647	Serine aminopeptidase, S33
M013TW_RS02150	COG0733	neurotransmitter:sodium symporter activity
M013TW_RS02155	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M013TW_RS02160	COG0626	cystathionine gamma-synthase activity
M013TW_RS02170	COG2011	ABC-type metal ion transport system permease component
M013TW_RS02175	COG1464	Belongs to the NlpA lipoprotein family
M013TW_RS02190	COG0494	nUDIX hydrolase
M013TW_RS02210	COG0583	DNA-binding transcription factor activity
M013TW_RS02215	COG0067	glutamate synthase
M013TW_RS02215	COG0069	glutamate synthase activity
M013TW_RS02215	COG0070	glutamate synthase
M013TW_RS02220	COG0493	'glutamate synthase
M013TW_RS02230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M013TW_RS02230	COG1263	PTS System
M013TW_RS02235	COG0366	Alpha amylase catalytic
M013TW_RS02240	COG2188	Transcriptional regulator
M013TW_RS02250	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M013TW_RS02290	COG1982	Orn Lys Arg decarboxylase major
M013TW_RS02300	COG3870	Protein conserved in bacteria
M013TW_RS02310	COG0470	DNA polymerase III
M013TW_RS02315	COG1774	PSP1 C-terminal conserved region
M013TW_RS02325	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
M013TW_RS02335	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M013TW_RS02350	COG0084	hydrolase, TatD family'
M013TW_RS02365	COG4466	Protein conserved in bacteria
M013TW_RS02375	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M013TW_RS02380	COG0251	oxidation-reduction process
M013TW_RS02425	COG2244	polysaccharide biosynthetic process
M013TW_RS02430	COG3956	TIGRFAM MazG family protein
M013TW_RS02435	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M013TW_RS02445	COG1098	S1 RNA binding domain
M013TW_RS02460	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M013TW_RS02485	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M013TW_RS02560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M013TW_RS02575	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M013TW_RS02585	COG3880	PFAM UvrB UvrC protein
M013TW_RS02605	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
M013TW_RS02610	COG4956	integral membrane protein (PIN domain superfamily)
M013TW_RS02630	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
M013TW_RS02720	COG1473	amidohydrolase
M013TW_RS02750	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M013TW_RS02755	COG1428	Deoxynucleoside kinase
M013TW_RS02760	COG1428	Deoxynucleoside kinase
M013TW_RS02770	COG0561	phosphatase activity
M013TW_RS02815	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M013TW_RS02925	COG0095	Lipoate-protein ligase
M013TW_RS02930	COG0083	homoserine kinase activity
M013TW_RS02950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M013TW_RS03000	COG0667	Aldo Keto reductase
M013TW_RS03005	COG0655	NAD(P)H dehydrogenase (quinone) activity
M013TW_RS03015	COG1078	dGTPase activity
M013TW_RS03050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M013TW_RS03055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M013TW_RS03105	COG4974	Belongs to the 'phage' integrase family
M013TW_RS03150	COG0803	Belongs to the bacterial solute-binding protein 9 family
M013TW_RS03155	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M013TW_RS03160	COG1121	(ABC) transporter
M013TW_RS03165	COG1321	iron dependent repressor
M013TW_RS03175	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
M013TW_RS03185	COG1682	transport, permease protein
M013TW_RS03190	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M013TW_RS03200	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
M013TW_RS03205	COG1686	Belongs to the peptidase S11 family
M013TW_RS03210	COG1132	(ABC) transporter
M013TW_RS03215	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M013TW_RS03225	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M013TW_RS03230	COG1120	ATPase activity
M013TW_RS03235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M013TW_RS03240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M013TW_RS03245	COG2376	Dihydroxyacetone kinase
M013TW_RS03255	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
M013TW_RS03265	COG3949	Membrane
M013TW_RS03290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M013TW_RS03305	COG1136	(ABC) transporter
M013TW_RS03310	COG0577	efflux transmembrane transporter activity
M013TW_RS03315	COG1392	Phosphate transport regulator
M013TW_RS03320	COG0306	phosphate transporter
M013TW_RS03325	COG1388	LysM domain
M013TW_RS03325	COG3942	CHAP domain
M013TW_RS03335	COG1917	Cupin 2, conserved barrel domain protein
M013TW_RS03335	COG4977	sequence-specific DNA binding
M013TW_RS03365	COG0583	DNA-binding transcription factor activity
M013TW_RS03375	COG2839	Protein conserved in bacteria
M013TW_RS03405	COG1611	Belongs to the LOG family
M013TW_RS03425	COG4988	ABC transporter
M013TW_RS03430	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M013TW_RS03440	COG0523	cobalamin synthesis protein
M013TW_RS03445	COG4989	oxidoreductase activity
M013TW_RS03455	COG0471	metal ion transport
M013TW_RS03460	COG0415	Belongs to the DNA photolyase family
M013TW_RS03490	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M013TW_RS03495	COG1349	DNA-binding transcription factor activity
M013TW_RS03500	COG1105	Belongs to the carbohydrate kinase PfkB family
M013TW_RS03505	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M013TW_RS03505	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M013TW_RS03505	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M013TW_RS03515	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M013TW_RS03520	COG1253	flavin adenine dinucleotide binding
M013TW_RS03525	COG0656	L-ascorbic acid biosynthetic process
M013TW_RS03530	COG0463	Glycosyl transferase, family 2
M013TW_RS03565	COG0720	synthase
M013TW_RS03575	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M013TW_RS03575	COG0512	Glutamine amidotransferase of anthranilate synthase
M013TW_RS03580	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M013TW_RS03615	COG0488	(ABC) transporter
M013TW_RS03620	COG0514	ATP-dependent DNA helicase (RecQ)
M013TW_RS03625	COG1125	glycine betaine transport
M013TW_RS03625	COG0517	IMP dehydrogenase activity
M013TW_RS03630	COG1174	glycine betaine transport
M013TW_RS03655	COG3104	oligopeptide transport
M013TW_RS03675	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M013TW_RS03680	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M013TW_RS03690	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M013TW_RS03695	COG4605	iron ion homeostasis
M013TW_RS03700	COG4604	ABC transporter, ATP-binding protein
M013TW_RS03705	COG4607	ABC-type enterochelin transport system periplasmic component
M013TW_RS03760	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M013TW_RS03765	COG1739	Uncharacterized protein family UPF0029
M013TW_RS03775	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
M013TW_RS03780	COG1040	competence protein
M013TW_RS03810	COG1388	LysM domain
M013TW_RS03810	COG3942	CHAP domain
M013TW_RS03865	COG0391	Required for morphogenesis under gluconeogenic growth conditions
M013TW_RS03885	COG0281	malic enzyme
M013TW_RS03940	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M013TW_RS03945	COG1647	Serine aminopeptidase, S33
M013TW_RS03950	COG0557	exoribonuclease II activity
M013TW_RS04010	COG1278	Cold shock
M013TW_RS04050	COG0406	alpha-ribazole phosphatase activity
M013TW_RS04055	COG1279	arginine transmembrane transporter activity
M013TW_RS04080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M013TW_RS04085	COG1393	Belongs to the ArsC family
M013TW_RS04100	COG3878	Protein conserved in bacteria
M013TW_RS04110	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
M013TW_RS04125	COG2011	ABC-type metal ion transport system permease component
M013TW_RS04130	COG1464	Belongs to the NlpA lipoprotein family
M013TW_RS04135	COG0582	viral genome integration into host DNA
M013TW_RS04240	COG5484	DNA packaging
M013TW_RS04240	COG3728	DNA packaging
M013TW_RS04280	COG0396	ATPase activity
M013TW_RS04285	COG0719	Fe-S assembly protein
M013TW_RS04295	COG0822	iron-sulfur transferase activity
M013TW_RS04315	COG1253	flavin adenine dinucleotide binding
M013TW_RS04330	COG1801	Protein of unknown function DUF72
M013TW_RS04335	COG0730	response to heat
M013TW_RS04350	COG4470	Protein conserved in bacteria
M013TW_RS04360	COG2445	Protein of unknown function DUF86
M013TW_RS04390	COG1696	Membrane protein involved in D-alanine export
M013TW_RS04400	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
M013TW_RS04405	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
M013TW_RS04410	COG4837	Protein of unknown function (DUF1462)
M013TW_RS04415	COG1252	NADH dehydrogenase
M013TW_RS04425	COG0316	Belongs to the HesB IscA family
M013TW_RS04435	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M013TW_RS04440	COG2056	Na+-H+ antiporter family
M013TW_RS04445	COG2050	protein possibly involved in aromatic compounds catabolism
M013TW_RS04500	COG1098	S1 RNA binding domain
M013TW_RS04505	COG1902	pentaerythritol trinitrate reductase activity
M013TW_RS04520	COG0584	glycerophosphoryl diester phosphodiesterase
M013TW_RS04540	COG0398	Pfam SNARE associated Golgi protein
M013TW_RS04580	COG0561	phosphatase activity
M013TW_RS04625	COG1881	PFAM PEBP family protein
M013TW_RS04655	COG0601	transmembrane transport
M013TW_RS04660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M013TW_RS04665	COG0444	Belongs to the ABC transporter superfamily
M013TW_RS04670	COG4608	Belongs to the ABC transporter superfamily
M013TW_RS04675	COG4166	transmembrane transport
M013TW_RS04680	COG0747	negative chemotaxis
M013TW_RS04685	COG0444	Belongs to the ABC transporter superfamily
M013TW_RS04690	COG4608	Belongs to the ABC transporter superfamily
M013TW_RS04695	COG0601	transmembrane transport
M013TW_RS04700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M013TW_RS04730	COG1164	Oligoendopeptidase f
M013TW_RS04740	COG2346	COG2346, Truncated hemoglobins
M013TW_RS04755	COG2357	RelA SpoT domain protein
M013TW_RS04765	COG0564	pseudouridine synthase activity
M013TW_RS04770	COG2239	Acts as a magnesium transporter
M013TW_RS04775	COG0569	domain protein
M013TW_RS04775	COG0475	glutathione-regulated potassium exporter activity
M013TW_RS04785	COG0628	permease
M013TW_RS04790	COG1115	amino acid carrier protein
M013TW_RS04840	COG0861	Integral membrane protein TerC family
M013TW_RS04855	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M013TW_RS04860	COG0737	Belongs to the 5'-nucleotidase family
M013TW_RS04875	COG4903	ComK protein
M013TW_RS04890	COG4873	Protein conserved in bacteria
M013TW_RS04945	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
M013TW_RS04955	COG2314	TM2 domain
M013TW_RS04960	COG0456	acetyltransferase
M013TW_RS04965	COG1575	Belongs to the MenA family. Type 1 subfamily
M013TW_RS04970	COG1169	isochorismate synthase
M013TW_RS04980	COG2267	carboxylic ester hydrolase activity
M013TW_RS05005	COG0436	Aminotransferase
M013TW_RS05040	COG1316	TRANSCRIPTIONal
M013TW_RS05085	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M013TW_RS05100	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M013TW_RS05140	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M013TW_RS05150	COG4721	ABC-type cobalt transport system, permease component
M013TW_RS05170	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M013TW_RS05190	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M013TW_RS05195	COG1271	oxidase subunit
M013TW_RS05200	COG1294	oxidase, subunit
M013TW_RS05205	COG0569	domain protein
M013TW_RS05270	COG1176	ABC-type spermidine putrescine transport system, permease component I
M013TW_RS05275	COG1177	transmembrane transport
M013TW_RS05280	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
M013TW_RS05305	COG0483	inositol monophosphate 1-phosphatase activity
M013TW_RS05315	COG1217	gtp-binding protein TYPA
M013TW_RS05325	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M013TW_RS05335	COG0772	Belongs to the SEDS family
M013TW_RS05370	COG3679	Belongs to the UPF0342 family
M013TW_RS05390	COG0742	ribosomal rna small subunit methyltransferase
M013TW_RS05450	COG4509	Sortase family
M013TW_RS05465	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M013TW_RS05495	COG1796	DNA polymerase
M013TW_RS05495	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M013TW_RS05525	COG2009	succinate dehydrogenase
M013TW_RS05530	COG1053	succinate dehydrogenase
M013TW_RS05535	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M013TW_RS05660	COG1288	antiporter activity
M013TW_RS05695	COG1011	Hydrolase
M013TW_RS05720	COG4839	cell division protein FtsL
M013TW_RS05725	COG0768	penicillin binding
M013TW_RS05740	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M013TW_RS05745	COG0849	cell division
M013TW_RS05760	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M013TW_RS05770	COG0762	integral membrane protein
M013TW_RS05775	COG2302	S4 RNA-binding domain
M013TW_RS05780	COG3599	regulation of cell shape
M013TW_RS05790	COG2514	catechol 2,3-dioxygenase activity
M013TW_RS05810	COG0564	pseudouridine synthase activity
M013TW_RS05820	COG2233	PERMEase
M013TW_RS05865	COG1293	RNA-binding protein homologous to eukaryotic snRNP
M013TW_RS05880	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M013TW_RS05885	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M013TW_RS05895	COG2314	TM2 domain
M013TW_RS05910	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M013TW_RS05910	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M013TW_RS05920	COG0631	protein serine/threonine phosphatase activity
M013TW_RS05935	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M013TW_RS05950	COG1302	Protein conserved in bacteria
M013TW_RS06000	COG1196	nuclear chromosome segregation
M013TW_RS06005	COG0552	protein localization to endoplasmic reticulum
M013TW_RS06015	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M013TW_RS06075	COG2348	transferase activity, transferring amino-acyl groups
M013TW_RS06080	COG0758	DNA mediated transformation
M013TW_RS06175	COG0195	Participates in both transcription termination and antitermination
M013TW_RS06180	COG2740	Nucleic-acid-binding protein implicated in transcription termination
M013TW_RS06205	COG0196	riboflavin kinase activity
M013TW_RS06230	COG2188	Transcriptional regulator
M013TW_RS06235	COG0612	Peptidase, M16
M013TW_RS06245	COG0300	oxidoreductase activity
M013TW_RS06270	COG1546	Belongs to the CinA family
M013TW_RS06270	COG1058	Belongs to the CinA family
M013TW_RS06290	COG1692	metallophosphoesterase
M013TW_RS06295	COG0674	pyruvate-flavodoxin oxidoreductase activity
M013TW_RS06295	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
M013TW_RS06300	COG1013	pyruvate-flavodoxin oxidoreductase activity
M013TW_RS06335	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
M013TW_RS06340	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M013TW_RS06365	COG1923	regulation of RNA biosynthetic process
M013TW_RS06375	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M013TW_RS06380	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
M013TW_RS06385	COG0789	Transcriptional regulator
M013TW_RS06515	COG1525	nuclease
M013TW_RS06530	COG0527	aspartate kinase activity
M013TW_RS06535	COG0460	homoserine dehydrogenase
M013TW_RS06540	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M013TW_RS06565	COG0833	amino acid
M013TW_RS06595	COG2340	Cysteine-rich secretory protein family
M013TW_RS06630	COG4846	Membrane protein involved in cytochrome C biogenesis
M013TW_RS06650	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M013TW_RS06660	COG0824	Thioesterase
M013TW_RS06680	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M013TW_RS06690	COG1115	amino acid carrier protein
M013TW_RS06705	COG0628	permease
M013TW_RS06730	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M013TW_RS06740	COG1363	Peptidase, m42
M013TW_RS06745	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M013TW_RS06750	COG0512	Glutamine amidotransferase of anthranilate synthase
M013TW_RS06790	COG0561	phosphatase activity
M013TW_RS06835	COG0704	Plays a role in the regulation of phosphate uptake
M013TW_RS06845	COG0581	inorganic phosphate transmembrane transporter activity
M013TW_RS06850	COG0573	inorganic phosphate transmembrane transporter activity
M013TW_RS06865	COG0488	(ABC) transporter
M013TW_RS06870	COG0527	aspartate kinase activity
M013TW_RS06875	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M013TW_RS06910	COG2808	Putative FMN-binding domain
M013TW_RS06955	COG4548	von Willebrand factor, type A
M013TW_RS06960	COG0714	Associated with various cellular activities
M013TW_RS06995	COG0671	phosphoesterase, PA-phosphatase related
M013TW_RS07100	COG0531	amino acid
M013TW_RS07115	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M013TW_RS07120	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
M013TW_RS07135	COG0116	Belongs to the methyltransferase superfamily
M013TW_RS07165	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M013TW_RS07165	COG4499	WXG100 protein secretion system (Wss), protein YukC
M013TW_RS07175	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M013TW_RS07180	COG3935	DnaD domain protein
M013TW_RS07205	COG0438	transferase activity, transferring glycosyl groups
M013TW_RS07210	COG1694	Mazg nucleotide pyrophosphohydrolase
M013TW_RS07215	COG2738	Putative neutral zinc metallopeptidase
M013TW_RS07220	COG4347	Protein of unknown function (DUF1405)
M013TW_RS07260	COG0142	geranyltranstransferase activity
M013TW_RS07325	COG0492	ferredoxin-NADP+ reductase activity
M013TW_RS07340	COG0514	ATP-dependent DNA helicase (RecQ)
M013TW_RS07350	COG1141	Ferredoxin
M013TW_RS07390	COG0860	N-Acetylmuramoyl-L-alanine amidase
M013TW_RS07390	COG1388	LysM domain
M013TW_RS07475	COG0740	serine-type endopeptidase activity
M013TW_RS07580	COG1484	DNA-dependent DNA replication
M013TW_RS07600	COG0629	single-stranded DNA binding
M013TW_RS07710	COG0582	viral genome integration into host DNA
M013TW_RS07730	COG5002	protein histidine kinase activity
M013TW_RS07735	COG0745	RESPONSE REGULATOR receiver
M013TW_RS07740	COG1187	pseudouridine synthase activity
M013TW_RS07765	COG0735	belongs to the Fur family
M013TW_RS07770	COG0494	nUDIX hydrolase
M013TW_RS07775	COG0667	Aldo Keto reductase
M013TW_RS07785	COG4221	oxidoreductase activity
M013TW_RS07800	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M013TW_RS07815	COG1609	Transcriptional regulator
M013TW_RS07835	COG2195	Cleaves the N-terminal amino acid of tripeptides
M013TW_RS07845	COG4129	membrane
M013TW_RS07855	COG0508	dehydrogenase complex catalyzes the overall conversion of
M013TW_RS07860	COG0022	dehydrogenase e1 component
M013TW_RS07865	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M013TW_RS07870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M013TW_RS07875	COG0497	DNA recombination
M013TW_RS07905	COG1302	Protein conserved in bacteria
M013TW_RS07910	COG0439	Biotin carboxylase
M013TW_RS07915	COG0511	ligase activity, forming carbon-carbon bonds
M013TW_RS07925	COG0006	proline dipeptidase activity
M013TW_RS07940	COG0095	Lipoate-protein ligase
M013TW_RS07945	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M013TW_RS07990	COG4537	Required for transformation and DNA binding
M013TW_RS07995	COG1459	type II secretion system
M013TW_RS08000	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M013TW_RS08005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M013TW_RS08010	COG0011	TIGRFAM Protein of
M013TW_RS08015	COG1940	carbohydrate kinase activity
M013TW_RS08020	COG4483	Protein conserved in bacteria
M013TW_RS08030	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M013TW_RS08040	COG0768	penicillin binding
M013TW_RS08055	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M013TW_RS08060	COG1121	(ABC) transporter
M013TW_RS08070	COG0513	Belongs to the DEAD box helicase family
M013TW_RS08080	COG2384	SAM-dependent methyltransferase
M013TW_RS08100	COG0517	IMP dehydrogenase activity
M013TW_RS08120	COG0295	cytidine deaminase activity
M013TW_RS08125	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M013TW_RS08135	COG1702	phosphate starvation-inducible protein PhoH
M013TW_RS08150	COG1030	water channel activity
M013TW_RS08160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M013TW_RS08165	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M013TW_RS08195	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M013TW_RS08210	COG1466	dna polymerase III delta subunit
M013TW_RS08215	COG2333	competence protein COMEC
M013TW_RS08215	COG0658	competence protein
M013TW_RS08220	COG2131	deaminase
M013TW_RS08230	COG2226	methyltransferase
M013TW_RS08235	COG0799	negative regulation of ribosome biogenesis
M013TW_RS08240	COG1713	HD superfamily hydrolase involved in NAD metabolism
M013TW_RS08250	COG1534	Rna-binding protein
M013TW_RS08260	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M013TW_RS08265	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
M013TW_RS08295	COG3177	Filamentation induced by cAMP protein fic
M013TW_RS08300	COG1914	H( )-stimulated, divalent metal cation uptake system
M013TW_RS08310	COG0439	Biotin carboxylase
M013TW_RS08315	COG0439	Biotin carboxylase
M013TW_RS08320	COG0439	Biotin carboxylase
M013TW_RS08325	COG0511	ligase activity, forming carbon-carbon bonds
M013TW_RS08330	COG1984	allophanate hydrolase subunit 2
M013TW_RS08335	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
M013TW_RS08350	COG0826	peptidase U32
M013TW_RS08355	COG0826	peptidase U32
M013TW_RS08385	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M013TW_RS08400	COG1104	cysteine desulfurase activity
M013TW_RS08405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M013TW_RS08415	COG3237	CsbD-like
M013TW_RS08420	COG1959	2 iron, 2 sulfur cluster binding
M013TW_RS08425	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M013TW_RS08430	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M013TW_RS08470	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
M013TW_RS08470	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M013TW_RS08475	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M013TW_RS08475	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M013TW_RS08480	COG1862	Preprotein translocase
M013TW_RS08520	COG2868	ribosomal protein
M013TW_RS08560	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M013TW_RS08570	COG0285	dihydrofolate synthase activity
M013TW_RS08580	COG2818	Glycosylase
M013TW_RS08615	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M013TW_RS08650	COG4112	unkown
M013TW_RS08675	COG0833	amino acid
M013TW_RS08690	COG1484	DNA-dependent DNA replication
M013TW_RS08720	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M013TW_RS08720	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M013TW_RS08730	COG5002	protein histidine kinase activity
M013TW_RS08735	COG0745	RESPONSE REGULATOR receiver
M013TW_RS08750	COG0372	Belongs to the citrate synthase family
M013TW_RS08755	COG1113	amino acid transport
M013TW_RS08780	COG0281	malic enzyme
M013TW_RS08790	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M013TW_RS08795	COG4109	DRTGG domain
M013TW_RS08835	COG0827	DNA restriction-modification system
M013TW_RS08845	COG0730	response to heat
M013TW_RS08855	COG1104	cysteine desulfurase activity
M013TW_RS08865	COG1956	GAF domain-containing protein
M013TW_RS08880	COG0584	glycerophosphoryl diester phosphodiesterase
M013TW_RS08885	COG1764	response to oxidative stress
M013TW_RS08890	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M013TW_RS08895	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M013TW_RS08920	COG1263	PTS System
M013TW_RS08920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M013TW_RS08925	COG0204	Acyl-transferase
M013TW_RS08930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M013TW_RS08965	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M013TW_RS08970	COG0454	-acetyltransferase
M013TW_RS08990	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
M013TW_RS08990	COG1605	Chorismate mutase
M013TW_RS09020	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M013TW_RS09030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M013TW_RS09035	COG1363	Peptidase, m42
M013TW_RS09045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M013TW_RS09055	COG0510	thiamine kinase activity
M013TW_RS09075	COG1187	pseudouridine synthase activity
M013TW_RS09080	COG2244	polysaccharide biosynthetic process
M013TW_RS09105	COG2814	Major facilitator Superfamily
M013TW_RS09110	COG1242	4 iron, 4 sulfur cluster binding
M013TW_RS09115	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
M013TW_RS09125	COG2267	carboxylic ester hydrolase activity
M013TW_RS09155	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M013TW_RS09155	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M013TW_RS09180	COG3266	domain, Protein
M013TW_RS09180	COG5632	N-Acetylmuramoyl-L-alanine amidase
M013TW_RS09180	COG4193	domain, Protein
M013TW_RS09215	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M013TW_RS09235	COG0656	L-ascorbic acid biosynthetic process
M013TW_RS09255	COG1506	peptidase
M013TW_RS09260	COG2816	NAD+ diphosphatase activity
M013TW_RS09360	COG0860	N-Acetylmuramoyl-L-alanine amidase
M013TW_RS09360	COG1388	LysM domain
M013TW_RS09440	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
M013TW_RS09470	COG1131	(ABC) transporter
M013TW_RS09475	COG0537	adenosine 5'-monophosphoramidase activity
M013TW_RS09505	COG0420	3'-5' exonuclease activity
M013TW_RS09530	COG2197	response regulator
M013TW_RS09535	COG2203	Gaf domain
M013TW_RS09535	COG4585	Histidine kinase
M013TW_RS09540	COG0564	pseudouridine synthase activity
M013TW_RS09580	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M013TW_RS09585	COG1126	abc transporter atp-binding protein
M013TW_RS09590	COG0765	amino acid transport
M013TW_RS09750	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M013TW_RS09755	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M013TW_RS09765	COG4129	membrane
M013TW_RS09785	COG1194	a g-specific adenine glycosylase
M013TW_RS09790	COG1988	membrane-bound metal-dependent
M013TW_RS09805	COG1388	LysM domain
M013TW_RS09805	COG1134	teichoic acid transport
M013TW_RS09835	COG0535	radical SAM domain protein
M013TW_RS09840	COG1607	acyl-coa hydrolase
M013TW_RS09845	COG2309	aminopeptidase activity
M013TW_RS09865	COG1295	ribonuclease BN
M013TW_RS09985	COG4851	CamS sex pheromone cAM373 precursor
M013TW_RS10005	COG4496	protein, YerC YecD
M013TW_RS10040	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M013TW_RS10050	COG0077	Prephenate dehydratase
M013TW_RS10060	COG0471	metal ion transport
M013TW_RS10070	COG1335	isochorismatase
M013TW_RS10085	COG1012	belongs to the aldehyde dehydrogenase family
M013TW_RS10135	COG1131	(ABC) transporter
M013TW_RS10150	COG1725	Transcriptional regulator
M013TW_RS10205	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M013TW_RS10270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M013TW_RS10275	COG1621	beta-fructofuranosidase activity
M013TW_RS10280	COG1609	Transcriptional regulator
M013TW_RS10285	COG0004	ammonium transporteR
M013TW_RS10290	COG0425	Belongs to the sulfur carrier protein TusA family
M013TW_RS10295	COG2391	methyltransferase activity
M013TW_RS10305	COG0488	(ABC) transporter
M013TW_RS10320	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
M013TW_RS10330	COG0456	acetyltransferase
M013TW_RS10335	COG1214	PFAM Peptidase M22, glycoprotease
M013TW_RS10340	COG0802	atpase or kinase
M013TW_RS10355	COG0028	Belongs to the TPP enzyme family
M013TW_RS10430	COG2183	response to ionizing radiation
M013TW_RS10435	COG1191	sigma factor activity
M013TW_RS10445	COG1366	Belongs to the anti-sigma-factor antagonist family
M013TW_RS10450	COG2208	phosphoserine phosphatase activity
M013TW_RS10485	COG3428	Bacterial PH domain
M013TW_RS10515	COG2205	protein histidine kinase activity
M013TW_RS10520	COG0745	RESPONSE REGULATOR receiver
M013TW_RS10530	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M013TW_RS10540	COG0772	Belongs to the SEDS family
M013TW_RS10555	COG1937	Protein conserved in bacteria
M013TW_RS10565	COG1418	mRNA catabolic process
M013TW_RS10610	COG0629	single-stranded DNA binding
M013TW_RS10700	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M013TW_RS10725	COG0009	L-threonylcarbamoyladenylate synthase
M013TW_RS10730	COG2890	protein-(glutamine-N5) methyltransferase activity
M013TW_RS10750	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M013TW_RS10790	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M013TW_RS10845	COG0813	purine-nucleoside phosphorylase activity
M013TW_RS10850	COG0783	Belongs to the Dps family
M013TW_RS10870	COG1482	cell wall glycoprotein biosynthetic process
M013TW_RS10875	COG0702	epimerase
M013TW_RS10880	COG0640	Transcriptional regulator
M013TW_RS10920	COG0561	phosphatase activity
M013TW_RS10925	COG1119	ATPase activity
M013TW_RS10940	COG3711	transcriptional antiterminator
M013TW_RS10970	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
M013TW_RS11030	COG0489	protein tyrosine kinase activity
M013TW_RS11035	COG2814	Major facilitator Superfamily
M013TW_RS11050	COG1272	protein, Hemolysin III
M013TW_RS11060	COG1988	membrane-bound metal-dependent
M013TW_RS11070	COG3314	Sporulation integral membrane protein YlbJ
M013TW_RS11075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M013TW_RS11080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M013TW_RS11085	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
M013TW_RS11095	COG3457	Alanine racemase
M013TW_RS11100	COG4264	IucA IucC family
M013TW_RS11105	COG2814	Major facilitator Superfamily
M013TW_RS11130	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M013TW_RS11140	COG2130	NADP-dependent
M013TW_RS11205	COG0656	L-ascorbic acid biosynthetic process
M013TW_RS11210	COG0789	Transcriptional regulator
M013TW_RS11220	COG5492	domain, Protein
M013TW_RS11225	COG2378	regulation of single-species biofilm formation
M013TW_RS11230	COG0693	protein deglycase activity
M013TW_RS11240	COG3527	Alpha-acetolactate decarboxylase
M013TW_RS11245	COG0028	Belongs to the TPP enzyme family
M013TW_RS11325	COG0201	protein transport
M013TW_RS11440	COG2252	PERMEase
M013TW_RS11485	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M013TW_RS11545	COG1763	Mo-molybdopterin cofactor biosynthetic process
M013TW_RS11565	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M013TW_RS11570	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
M013TW_RS11575	COG4149	molybdate abc transporter
M013TW_RS11580	COG0725	ABC transporter, periplasmic molybdate-binding protein
M013TW_RS11595	COG1268	BioY protein
M013TW_RS11610	COG1960	acyl-CoA dehydrogenase activity
M013TW_RS11615	COG4413	Urea transporter
M013TW_RS11690	COG1757	Na H antiporter
M013TW_RS11705	COG3942	CHAP domain
M013TW_RS11745	COG1316	TRANSCRIPTIONal
M013TW_RS11775	COG1113	amino acid transport
M013TW_RS11795	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M013TW_RS11800	COG0385	Bile acid
M013TW_RS11810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M013TW_RS11810	COG1263	PTS System
M013TW_RS11815	COG1737	Transcriptional regulator
M013TW_RS11835	COG1028	Short-chain dehydrogenase reductase Sdr
M013TW_RS11840	COG1473	amidohydrolase
M013TW_RS11855	COG0583	DNA-binding transcription factor activity
M013TW_RS11875	COG2258	MOSC domain
M013TW_RS11895	COG1668	transmembrane transport
M013TW_RS11900	COG4152	abc transporter atp-binding protein
M013TW_RS11905	COG3152	Membrane
M013TW_RS11915	COG0786	glutamate:sodium symporter activity
M013TW_RS11925	COG0598	Magnesium transport protein CorA
M013TW_RS11940	COG0657	acetylesterase activity
M013TW_RS11950	COG2814	Major facilitator Superfamily
M013TW_RS11955	COG1566	PFAM secretion protein HlyD family protein
M013TW_RS11970	COG2814	Major facilitator Superfamily
M013TW_RS12035	COG1131	(ABC) transporter
M013TW_RS12050	COG1620	l-lactate permease
M013TW_RS12070	COG0604	alcohol dehydrogenase
M013TW_RS12100	COG1511	domain protein
M013TW_RS12115	COG1263	PTS System
M013TW_RS12115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M013TW_RS12130	COG3871	stress protein (general stress protein 26)
M013TW_RS12170	COG0789	Transcriptional regulator
M013TW_RS12190	COG2181	nitrate reductase activity
M013TW_RS12200	COG1140	nitrate reductase beta subunit
M013TW_RS12205	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
M013TW_RS12215	COG2146	nitrite reductase [NAD(P)H] activity
M013TW_RS12220	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M013TW_RS12230	COG0454	-acetyltransferase
M013TW_RS12235	COG2116	formate transmembrane transporter activity
M013TW_RS12250	COG0803	Belongs to the bacterial solute-binding protein 9 family
M013TW_RS12250	COG3443	Belongs to the bacterial solute-binding protein 9 family
M013TW_RS12285	COG1126	abc transporter atp-binding protein
M013TW_RS12290	COG0765	amino acid transport
M013TW_RS12295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M013TW_RS12300	COG2814	Major facilitator Superfamily
M013TW_RS12315	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M013TW_RS12360	COG0156	8-amino-7-oxononanoate synthase activity
M013TW_RS12370	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M013TW_RS12375	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
M013TW_RS12390	COG1132	(ABC) transporter
M013TW_RS12395	COG1132	(ABC) transporter
M013TW_RS12395	COG2375	cellular response to nickel ion
M013TW_RS12410	COG1929	Belongs to the glycerate kinase type-1 family
M013TW_RS12420	COG2814	Major facilitator Superfamily
M013TW_RS12435	COG1408	metallophosphoesterase
M013TW_RS12440	COG1113	amino acid transport
M013TW_RS12455	COG0531	amino acid
M013TW_RS12480	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M013TW_RS12490	COG1174	glycine betaine transport
M013TW_RS12500	COG1174	glycine betaine transport
M013TW_RS12520	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
M013TW_RS12525	COG0531	amino acid
M013TW_RS12530	COG2272	Belongs to the type-B carboxylesterase lipase family
M013TW_RS12535	COG2814	Major facilitator Superfamily
M013TW_RS12540	COG0390	transport system, permease component
M013TW_RS12545	COG4619	ABC transporter
M013TW_RS12550	COG1363	Peptidase, m42
M013TW_RS12555	COG4808	Protein conserved in bacteria
M013TW_RS12560	COG0069	glutamate synthase activity
M013TW_RS12575	COG1124	(ABC) transporter
M013TW_RS12585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M013TW_RS12590	COG0601	transmembrane transport
M013TW_RS12595	COG0747	negative chemotaxis
M013TW_RS12620	COG1028	Short-chain dehydrogenase reductase Sdr
M013TW_RS12625	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
M013TW_RS12630	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M013TW_RS12730	COG0494	nUDIX hydrolase
M013TW_RS12785	COG1846	Transcriptional regulator
M013TW_RS12815	COG1070	Carbohydrate kinase
M013TW_RS12820	COG1802	Transcriptional regulator
M013TW_RS12825	COG0789	Transcriptional regulator
M013TW_RS12830	COG2357	RelA SpoT domain protein
M013TW_RS12835	COG4876	unkown
M013TW_RS12845	COG2271	Major facilitator Superfamily
M013TW_RS12850	COG0586	Pfam SNARE associated Golgi protein
M013TW_RS12860	COG1131	(ABC) transporter
M013TW_RS12870	COG1073	alpha beta
M013TW_RS12880	COG1073	alpha beta
M013TW_RS12905	COG3949	Membrane
M013TW_RS12910	COG0400	carboxylic ester hydrolase activity
M013TW_RS12915	COG0346	lactoylglutathione lyase activity
M013TW_RS12920	COG1846	Transcriptional regulator
M013TW_RS12935	COG2514	catechol 2,3-dioxygenase activity
M013TW_RS12950	COG0561	phosphatase activity
M013TW_RS12955	COG1131	(ABC) transporter
M013TW_RS12965	COG3764	Sortase (surface protein transpeptidase)
M013TW_RS12985	COG1760	l-serine dehydratase
M013TW_RS12990	COG1760	l-serine dehydratase
M013TW_RS13005	COG0697	spore germination
M013TW_RS13010	COG0657	acetylesterase activity
M013TW_RS13030	COG0028	Belongs to the TPP enzyme family
M013TW_RS13045	COG0583	DNA-binding transcription factor activity
M013TW_RS13055	COG3942	CHAP domain
M013TW_RS13065	COG3425	synthase
M013TW_RS13075	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M013TW_RS13100	COG2409	Drug exporters of the RND superfamily
M013TW_RS13145	COG0436	Aminotransferase
M013TW_RS13185	COG0456	acetyltransferase
M013TW_RS13255	COG0596	Alpha beta hydrolase
M013TW_RS13290	COG3001	Fructosamine kinase
M013TW_RS13295	COG0167	dihydroorotate dehydrogenase activity
M013TW_RS13365	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M013TW_RS13370	COG3527	Alpha-acetolactate decarboxylase
M013TW_RS13385	COG0531	amino acid
M013TW_RS13415	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M013TW_RS13435	COG1012	belongs to the aldehyde dehydrogenase family
M013TW_RS13445	COG1510	regulation of RNA biosynthetic process
M013TW_RS13450	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M013TW_RS13475	COG2851	Citrate transporter
M013TW_RS13485	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M013TW_RS13495	COG0386	Belongs to the glutathione peroxidase family
M013TW_RS13520	COG1136	(ABC) transporter
M013TW_RS13525	COG2205	protein histidine kinase activity
M013TW_RS13530	COG0745	RESPONSE REGULATOR receiver
M013TW_RS13545	COG1785	Belongs to the alkaline phosphatase family
M013TW_RS13595	COG1438	arginine binding
M013TW_RS13615	COG3711	transcriptional antiterminator
M013TW_RS13615	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M013TW_RS13620	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M013TW_RS13620	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M013TW_RS13620	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M013TW_RS13625	COG1482	cell wall glycoprotein biosynthetic process
M013TW_RS13635	COG3942	CHAP domain
M013TW_RS13635	COG1705	Flagellar rod assembly protein muramidase FlgJ
M013TW_RS13640	COG1535	isochorismatase
M013TW_RS13640	COG3433	isochorismatase activity
M013TW_RS13655	COG0438	transferase activity, transferring glycosyl groups
M013TW_RS13670	COG1073	alpha beta
M013TW_RS13690	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M013TW_RS13720	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M013TW_RS13825	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M013TW_RS13910	COG0471	metal ion transport
M013TW_RS13915	COG2962	Rard protein
M013TW_RS13925	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
M013TW_RS13940	COG1136	(ABC) transporter
M013TW_RS13945	COG0577	efflux transmembrane transporter activity
M013TW_RS13970	COG1278	Cold shock
M013TW_RS13990	COG1475	DNA binding