locus-tag	class	description
M013TW_RS00020	COG2501	S4 domain
M013TW_RS00040	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M013TW_RS00065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M013TW_RS00075	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
M013TW_RS00085	COG0305	Participates in initiation and elongation during chromosome replication
M013TW_RS00115	COG4863	YycH protein
M013TW_RS00125	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
M013TW_RS00130	COG0737	Belongs to the 5'-nucleotidase family
M013TW_RS00155	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M013TW_RS00155	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M013TW_RS00195	COG3425	synthase
M013TW_RS00205	COG0584	glycerophosphoryl diester phosphodiesterase
M013TW_RS00210	COG2030	dehydratase
M013TW_RS00270	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M013TW_RS00300	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
M013TW_RS00310	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
M013TW_RS00315	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M013TW_RS00320	COG0210	DNA helicase
M013TW_RS00330	COG0076	glutamate decarboxylase activity
M013TW_RS00365	COG1522	sequence-specific DNA binding
M013TW_RS00375	COG0456	acetyltransferase
M013TW_RS00400	COG0655	NAD(P)H dehydrogenase (quinone) activity
M013TW_RS00435	COG0823	Involved in the tonB-independent uptake of proteins
M013TW_RS00450	COG1473	amidohydrolase
M013TW_RS00460	COG1283	sodium-dependent phosphate transmembrane transporter activity
M013TW_RS00465	COG4716	Myosin-crossreactive antigen
M013TW_RS00470	COG0697	spore germination
M013TW_RS00485	COG1620	l-lactate permease
M013TW_RS00505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M013TW_RS00510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M013TW_RS00515	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M013TW_RS00525	COG2423	ornithine cyclodeaminase activity
M013TW_RS00530	COG4264	IucA IucC family
M013TW_RS00535	COG2814	Major facilitator Superfamily
M013TW_RS00540	COG4264	IucA IucC family
M013TW_RS00545	COG4264	IucA IucC family
M013TW_RS00555	COG0019	diaminopimelate decarboxylase activity
M013TW_RS00560	COG1475	DNA binding
M013TW_RS00585	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M013TW_RS00590	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M013TW_RS00595	COG0438	transferase activity, transferring glycosyl groups
M013TW_RS00625	COG0813	purine-nucleoside phosphorylase activity
M013TW_RS00630	COG2814	Major facilitator Superfamily
M013TW_RS00650	COG3639	organic phosphonate transmembrane transporter activity
M013TW_RS00670	COG0737	Belongs to the 5'-nucleotidase family
M013TW_RS00685	COG1454	alcohol dehydrogenase
M013TW_RS00685	COG1012	belongs to the aldehyde dehydrogenase family
M013TW_RS00710	COG1086	Polysaccharide biosynthesis protein
M013TW_RS00720	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M013TW_RS00750	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M013TW_RS00760	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M013TW_RS00765	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M013TW_RS00775	COG2832	Protein of unknown function (DUF454)
M013TW_RS00810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M013TW_RS00815	COG1960	acyl-CoA dehydrogenase activity
M013TW_RS00835	COG3477	response to acidic pH
M013TW_RS00860	COG1114	Component of the transport system for branched-chain amino acids
M013TW_RS00865	COG1335	isochorismatase
M013TW_RS00870	COG3961	Belongs to the TPP enzyme family
M013TW_RS00900	COG1737	Transcriptional regulator
M013TW_RS00925	COG0601	transmembrane transport
M013TW_RS00930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M013TW_RS00940	COG0405	Gamma-glutamyltransferase
M013TW_RS00960	COG3842	ATPase activity
M013TW_RS00970	COG1175	transmembrane transport
M013TW_RS00975	COG3833	ABC-type maltose transport systems, permease component
M013TW_RS00980	COG0673	inositol 2-dehydrogenase activity
M013TW_RS00985	COG0673	inositol 2-dehydrogenase activity
M013TW_RS00995	COG1755	Isoprenylcysteine carboxyl methyltransferase
M013TW_RS01055	COG0183	Belongs to the thiolase family
M013TW_RS01065	COG1960	acyl-CoA dehydrogenase activity
M013TW_RS01070	COG0318	PFAM AMP-dependent synthetase and ligase
M013TW_RS01085	COG0747	negative chemotaxis
M013TW_RS01090	COG3189	MarR family transcriptional regulator
M013TW_RS01115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M013TW_RS01115	COG1263	PTS System
M013TW_RS01115	COG2190	(PTS) system
M013TW_RS01120	COG1957	nucleoside hydrolase
M013TW_RS01140	COG3414	Phosphotransferase system galactitol-specific IIB component
M013TW_RS01145	COG3775	system Galactitol-specific IIC component
M013TW_RS01150	COG1063	alcohol dehydrogenase
M013TW_RS01160	COG1063	alcohol dehydrogenase
M013TW_RS01170	COG1063	alcohol dehydrogenase
M013TW_RS01175	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M013TW_RS01180	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M013TW_RS01190	COG1063	alcohol dehydrogenase
M013TW_RS01195	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M013TW_RS01230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M013TW_RS01235	COG1263	PTS System
M013TW_RS01235	COG2190	(PTS) system
M013TW_RS01235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M013TW_RS01240	COG2723	6-phospho-beta-galactosidase activity
M013TW_RS01245	COG2226	methyltransferase
M013TW_RS01300	COG1131	(ABC) transporter
M013TW_RS01320	COG1388	LysM domain
M013TW_RS01320	COG3942	CHAP domain
M013TW_RS01445	COG1114	Component of the transport system for branched-chain amino acids
M013TW_RS01455	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
M013TW_RS01465	COG0577	efflux transmembrane transporter activity
M013TW_RS01495	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M013TW_RS01500	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M013TW_RS01525	COG3314	Sporulation integral membrane protein YlbJ
M013TW_RS01550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M013TW_RS01575	COG3037	sugar-specific permease SgaT UlaA
M013TW_RS01585	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M013TW_RS01590	COG3711	transcriptional antiterminator
M013TW_RS01610	COG2271	Major facilitator Superfamily
M013TW_RS01615	COG0346	lactoylglutathione lyase activity
M013TW_RS01620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M013TW_RS01625	COG0431	NADPH-dependent FMN reductase
M013TW_RS01635	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M013TW_RS01640	COG2822	iron ion transport
M013TW_RS01650	COG0672	)-iron permease
M013TW_RS01655	COG0805	protein transport
M013TW_RS01660	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M013TW_RS01670	COG1476	TRANSCRIPTIONal
M013TW_RS01680	COG1131	(ABC) transporter
M013TW_RS01710	COG0646	methionine synthase
M013TW_RS01710	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M013TW_RS01715	COG0626	cystathionine gamma-synthase activity
M013TW_RS01720	COG0626	cystathionine gamma-synthase activity
M013TW_RS01725	COG1475	DNA binding
M013TW_RS01730	COG0668	transmembrane transport
M013TW_RS01735	COG4481	Protein conserved in bacteria
M013TW_RS01740	COG0012	GTP binding
M013TW_RS01780	COG4974	Belongs to the 'phage' integrase family
M013TW_RS01855	COG1823	symporter activity
M013TW_RS01890	COG2233	PERMEase
M013TW_RS01950	COG1683	Conserved Protein
M013TW_RS01960	COG3759	membrane
M013TW_RS02125	COG0523	cobalamin synthesis protein
M013TW_RS02150	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M013TW_RS02160	COG5609	conserved protein (DUF2294)
M013TW_RS02175	COG1647	Serine aminopeptidase, S33
M013TW_RS02180	COG0733	neurotransmitter:sodium symporter activity
M013TW_RS02185	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M013TW_RS02190	COG0626	cystathionine gamma-synthase activity
M013TW_RS02200	COG2011	ABC-type metal ion transport system permease component
M013TW_RS02205	COG1464	Belongs to the NlpA lipoprotein family
M013TW_RS02220	COG0494	nUDIX hydrolase
M013TW_RS02240	COG0583	DNA-binding transcription factor activity
M013TW_RS02245	COG0067	glutamate synthase
M013TW_RS02245	COG0070	glutamate synthase
M013TW_RS02245	COG0069	glutamate synthase activity
M013TW_RS02250	COG0493	'glutamate synthase
M013TW_RS02260	COG1263	PTS System
M013TW_RS02260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M013TW_RS02265	COG0366	Alpha amylase catalytic
M013TW_RS02270	COG2188	Transcriptional regulator
M013TW_RS02290	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M013TW_RS02325	COG1982	Orn Lys Arg decarboxylase major
M013TW_RS02335	COG3870	Protein conserved in bacteria
M013TW_RS02340	COG0470	DNA polymerase III
M013TW_RS02345	COG1774	PSP1 C-terminal conserved region
M013TW_RS02355	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
M013TW_RS02365	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M013TW_RS02375	COG0084	hydrolase, TatD family'
M013TW_RS02380	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
M013TW_RS02390	COG4466	Protein conserved in bacteria
M013TW_RS02400	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M013TW_RS02405	COG0251	oxidation-reduction process
M013TW_RS02450	COG2244	polysaccharide biosynthetic process
M013TW_RS02455	COG3956	TIGRFAM MazG family protein
M013TW_RS02460	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M013TW_RS02470	COG1098	S1 RNA binding domain
M013TW_RS02485	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M013TW_RS02510	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M013TW_RS02605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M013TW_RS02620	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M013TW_RS02630	COG3880	PFAM UvrB UvrC protein
M013TW_RS02645	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
M013TW_RS02650	COG4956	integral membrane protein (PIN domain superfamily)
M013TW_RS02670	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
M013TW_RS02730	COG2813	Specifically methylates the guanine in position
M013TW_RS02770	COG1473	amidohydrolase
M013TW_RS02800	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M013TW_RS02805	COG1428	Deoxynucleoside kinase
M013TW_RS02810	COG1428	Deoxynucleoside kinase
M013TW_RS02820	COG0561	phosphatase activity
M013TW_RS02865	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M013TW_RS02980	COG0095	Lipoate-protein ligase
M013TW_RS02985	COG0083	homoserine kinase activity
M013TW_RS03005	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M013TW_RS03055	COG0667	Aldo Keto reductase
M013TW_RS03060	COG0655	NAD(P)H dehydrogenase (quinone) activity
M013TW_RS03070	COG1078	dGTPase activity
M013TW_RS03100	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M013TW_RS03105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M013TW_RS03155	COG4974	Belongs to the 'phage' integrase family
M013TW_RS03200	COG0803	Belongs to the bacterial solute-binding protein 9 family
M013TW_RS03205	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M013TW_RS03210	COG1121	(ABC) transporter
M013TW_RS03215	COG1321	iron dependent repressor
M013TW_RS03225	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
M013TW_RS03235	COG1682	transport, permease protein
M013TW_RS03240	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M013TW_RS03250	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
M013TW_RS03255	COG1686	Belongs to the peptidase S11 family
M013TW_RS03260	COG1132	(ABC) transporter
M013TW_RS03265	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M013TW_RS03275	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M013TW_RS03280	COG1120	ATPase activity
M013TW_RS03285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M013TW_RS03290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M013TW_RS03295	COG2376	Dihydroxyacetone kinase
M013TW_RS03305	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
M013TW_RS03315	COG3949	Membrane
M013TW_RS03335	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M013TW_RS03350	COG1136	(ABC) transporter
M013TW_RS03355	COG0577	efflux transmembrane transporter activity
M013TW_RS03360	COG1392	Phosphate transport regulator
M013TW_RS03365	COG0306	phosphate transporter
M013TW_RS03370	COG1388	LysM domain
M013TW_RS03370	COG3942	CHAP domain
M013TW_RS03380	COG1917	Cupin 2, conserved barrel domain protein
M013TW_RS03380	COG4977	sequence-specific DNA binding
M013TW_RS03410	COG0583	DNA-binding transcription factor activity
M013TW_RS03420	COG2839	Protein conserved in bacteria
M013TW_RS03450	COG1611	Belongs to the LOG family
M013TW_RS03470	COG4988	ABC transporter
M013TW_RS03475	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M013TW_RS03485	COG0523	cobalamin synthesis protein
M013TW_RS03490	COG4989	oxidoreductase activity
M013TW_RS03500	COG0471	metal ion transport
M013TW_RS03505	COG0415	Belongs to the DNA photolyase family
M013TW_RS03535	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M013TW_RS03540	COG1349	DNA-binding transcription factor activity
M013TW_RS03545	COG1105	Belongs to the carbohydrate kinase PfkB family
M013TW_RS03550	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M013TW_RS03550	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M013TW_RS03550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M013TW_RS03555	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M013TW_RS03560	COG1253	flavin adenine dinucleotide binding
M013TW_RS03565	COG0656	L-ascorbic acid biosynthetic process
M013TW_RS03570	COG0463	Glycosyl transferase, family 2
M013TW_RS03605	COG0720	synthase
M013TW_RS03615	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M013TW_RS03615	COG0512	Glutamine amidotransferase of anthranilate synthase
M013TW_RS03620	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M013TW_RS03650	COG0488	(ABC) transporter
M013TW_RS03655	COG0514	ATP-dependent DNA helicase (RecQ)
M013TW_RS03660	COG0517	IMP dehydrogenase activity
M013TW_RS03660	COG1125	glycine betaine transport
M013TW_RS03665	COG1174	glycine betaine transport
M013TW_RS03695	COG3104	oligopeptide transport
M013TW_RS03725	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M013TW_RS03730	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M013TW_RS03740	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M013TW_RS03745	COG4605	iron ion homeostasis
M013TW_RS03750	COG4604	ABC transporter, ATP-binding protein
M013TW_RS03755	COG4607	ABC-type enterochelin transport system periplasmic component
M013TW_RS03810	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M013TW_RS03815	COG1739	Uncharacterized protein family UPF0029
M013TW_RS03825	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
M013TW_RS03830	COG1040	competence protein
M013TW_RS03860	COG1388	LysM domain
M013TW_RS03860	COG3942	CHAP domain
M013TW_RS03915	COG0391	Required for morphogenesis under gluconeogenic growth conditions
M013TW_RS03930	COG0281	malic enzyme
M013TW_RS03980	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M013TW_RS03985	COG1647	Serine aminopeptidase, S33
M013TW_RS03990	COG0557	exoribonuclease II activity
M013TW_RS04055	COG1278	Cold shock
M013TW_RS04095	COG0406	alpha-ribazole phosphatase activity
M013TW_RS04100	COG1279	arginine transmembrane transporter activity
M013TW_RS04125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M013TW_RS04130	COG1393	Belongs to the ArsC family
M013TW_RS04145	COG3878	Protein conserved in bacteria
M013TW_RS04150	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
M013TW_RS04165	COG2011	ABC-type metal ion transport system permease component
M013TW_RS04170	COG1464	Belongs to the NlpA lipoprotein family
M013TW_RS04175	COG0582	viral genome integration into host DNA
M013TW_RS04285	COG3728	DNA packaging
M013TW_RS04285	COG5484	DNA packaging
M013TW_RS04325	COG0396	ATPase activity
M013TW_RS04330	COG0719	Fe-S assembly protein
M013TW_RS04340	COG0822	iron-sulfur transferase activity
M013TW_RS04365	COG1253	flavin adenine dinucleotide binding
M013TW_RS04380	COG1801	Protein of unknown function DUF72
M013TW_RS04385	COG0730	response to heat
M013TW_RS04400	COG4470	Protein conserved in bacteria
M013TW_RS04410	COG2445	Protein of unknown function DUF86
M013TW_RS04440	COG1696	Membrane protein involved in D-alanine export
M013TW_RS04450	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
M013TW_RS04455	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
M013TW_RS04460	COG4837	Protein of unknown function (DUF1462)
M013TW_RS04465	COG1252	NADH dehydrogenase
M013TW_RS04475	COG0316	Belongs to the HesB IscA family
M013TW_RS04485	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M013TW_RS04490	COG2056	Na+-H+ antiporter family
M013TW_RS04495	COG2050	protein possibly involved in aromatic compounds catabolism
M013TW_RS04550	COG1098	S1 RNA binding domain
M013TW_RS04555	COG1902	pentaerythritol trinitrate reductase activity
M013TW_RS04570	COG0584	glycerophosphoryl diester phosphodiesterase
M013TW_RS04595	COG0398	Pfam SNARE associated Golgi protein
M013TW_RS04635	COG0561	phosphatase activity
M013TW_RS04660	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M013TW_RS04675	COG1881	PFAM PEBP family protein
M013TW_RS04705	COG0601	transmembrane transport
M013TW_RS04710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M013TW_RS04715	COG0444	Belongs to the ABC transporter superfamily
M013TW_RS04720	COG4608	Belongs to the ABC transporter superfamily
M013TW_RS04725	COG4166	transmembrane transport
M013TW_RS04730	COG0747	negative chemotaxis
M013TW_RS04735	COG0444	Belongs to the ABC transporter superfamily
M013TW_RS04740	COG4608	Belongs to the ABC transporter superfamily
M013TW_RS04745	COG0601	transmembrane transport
M013TW_RS04750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M013TW_RS04780	COG1164	Oligoendopeptidase f
M013TW_RS04790	COG2346	COG2346, Truncated hemoglobins
M013TW_RS04805	COG2357	RelA SpoT domain protein
M013TW_RS04815	COG0564	pseudouridine synthase activity
M013TW_RS04820	COG2239	Acts as a magnesium transporter
M013TW_RS04825	COG0475	glutathione-regulated potassium exporter activity
M013TW_RS04825	COG0569	domain protein
M013TW_RS04835	COG0628	permease
M013TW_RS04840	COG1115	amino acid carrier protein
M013TW_RS04890	COG0861	Integral membrane protein TerC family
M013TW_RS04900	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M013TW_RS04905	COG0737	Belongs to the 5'-nucleotidase family
M013TW_RS04920	COG4903	ComK protein
M013TW_RS04935	COG4873	Protein conserved in bacteria
M013TW_RS04995	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
M013TW_RS05005	COG2314	TM2 domain
M013TW_RS05010	COG0456	acetyltransferase
M013TW_RS05015	COG1575	Belongs to the MenA family. Type 1 subfamily
M013TW_RS05025	COG1169	isochorismate synthase
M013TW_RS05035	COG2267	carboxylic ester hydrolase activity
M013TW_RS05060	COG0436	Aminotransferase
M013TW_RS05065	COG3594	Acyltransferase
M013TW_RS05095	COG1316	TRANSCRIPTIONal
M013TW_RS05140	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M013TW_RS05155	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M013TW_RS05200	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M013TW_RS05205	COG4172	Belongs to the ABC transporter superfamily
M013TW_RS05210	COG4721	ABC-type cobalt transport system, permease component
M013TW_RS05230	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M013TW_RS05250	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M013TW_RS05255	COG1271	oxidase subunit
M013TW_RS05260	COG1294	oxidase, subunit
M013TW_RS05265	COG0569	domain protein
M013TW_RS05330	COG1176	ABC-type spermidine putrescine transport system, permease component I
M013TW_RS05335	COG1177	transmembrane transport
M013TW_RS05340	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
M013TW_RS05365	COG0483	inositol monophosphate 1-phosphatase activity
M013TW_RS05375	COG1217	gtp-binding protein TYPA
M013TW_RS05385	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M013TW_RS05395	COG0772	Belongs to the SEDS family
M013TW_RS05425	COG3679	Belongs to the UPF0342 family
M013TW_RS05445	COG0742	ribosomal rna small subunit methyltransferase
M013TW_RS05505	COG4509	Sortase family
M013TW_RS05520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M013TW_RS05550	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M013TW_RS05550	COG1796	DNA polymerase
M013TW_RS05575	COG2009	succinate dehydrogenase
M013TW_RS05580	COG1053	succinate dehydrogenase
M013TW_RS05585	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M013TW_RS05695	COG1288	antiporter activity
M013TW_RS05730	COG1011	Hydrolase
M013TW_RS05755	COG4839	cell division protein FtsL
M013TW_RS05760	COG0768	penicillin binding
M013TW_RS05775	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M013TW_RS05780	COG0849	cell division
M013TW_RS05795	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M013TW_RS05805	COG0762	integral membrane protein
M013TW_RS05810	COG2302	S4 RNA-binding domain
M013TW_RS05815	COG3599	regulation of cell shape
M013TW_RS05825	COG2514	catechol 2,3-dioxygenase activity
M013TW_RS05840	COG0564	pseudouridine synthase activity
M013TW_RS05850	COG2233	PERMEase
M013TW_RS05895	COG1293	RNA-binding protein homologous to eukaryotic snRNP
M013TW_RS05910	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M013TW_RS05915	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M013TW_RS05925	COG2314	TM2 domain
M013TW_RS05940	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M013TW_RS05940	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M013TW_RS05950	COG0631	protein serine/threonine phosphatase activity
M013TW_RS05965	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M013TW_RS05980	COG1302	Protein conserved in bacteria
M013TW_RS06025	COG1196	nuclear chromosome segregation
M013TW_RS06030	COG0552	protein localization to endoplasmic reticulum
M013TW_RS06040	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M013TW_RS06095	COG2348	transferase activity, transferring amino-acyl groups
M013TW_RS06100	COG0758	DNA mediated transformation
M013TW_RS06195	COG0195	Participates in both transcription termination and antitermination
M013TW_RS06200	COG2740	Nucleic-acid-binding protein implicated in transcription termination
M013TW_RS06225	COG0196	riboflavin kinase activity
M013TW_RS06250	COG2188	Transcriptional regulator
M013TW_RS06255	COG0612	Peptidase, M16
M013TW_RS06260	COG0612	Peptidase, M16
M013TW_RS06265	COG0300	oxidoreductase activity
M013TW_RS06285	COG1546	Belongs to the CinA family
M013TW_RS06285	COG1058	Belongs to the CinA family
M013TW_RS06305	COG1692	metallophosphoesterase
M013TW_RS06310	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
M013TW_RS06310	COG0674	pyruvate-flavodoxin oxidoreductase activity
M013TW_RS06315	COG1013	pyruvate-flavodoxin oxidoreductase activity
M013TW_RS06350	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
M013TW_RS06355	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M013TW_RS06380	COG1923	regulation of RNA biosynthetic process
M013TW_RS06390	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M013TW_RS06395	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
M013TW_RS06400	COG0789	Transcriptional regulator
M013TW_RS06540	COG1525	nuclease
M013TW_RS06555	COG0527	aspartate kinase activity
M013TW_RS06560	COG0460	homoserine dehydrogenase
M013TW_RS06565	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M013TW_RS06590	COG0833	amino acid
M013TW_RS06620	COG2340	Cysteine-rich secretory protein family
M013TW_RS06655	COG4846	Membrane protein involved in cytochrome C biogenesis
M013TW_RS06675	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M013TW_RS06685	COG0824	Thioesterase
M013TW_RS06710	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M013TW_RS06715	COG1115	amino acid carrier protein
M013TW_RS06730	COG0628	permease
M013TW_RS06755	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M013TW_RS06765	COG1363	Peptidase, m42
M013TW_RS06770	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M013TW_RS06775	COG0512	Glutamine amidotransferase of anthranilate synthase
M013TW_RS06815	COG0561	phosphatase activity
M013TW_RS06860	COG0704	Plays a role in the regulation of phosphate uptake
M013TW_RS06870	COG0581	inorganic phosphate transmembrane transporter activity
M013TW_RS06875	COG0573	inorganic phosphate transmembrane transporter activity
M013TW_RS06890	COG0488	(ABC) transporter
M013TW_RS06895	COG0527	aspartate kinase activity
M013TW_RS06900	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M013TW_RS06935	COG2808	Putative FMN-binding domain
M013TW_RS06980	COG4548	von Willebrand factor, type A
M013TW_RS06985	COG0714	Associated with various cellular activities
M013TW_RS07025	COG0671	phosphoesterase, PA-phosphatase related
M013TW_RS07100	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M013TW_RS07120	COG0531	amino acid
M013TW_RS07135	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M013TW_RS07140	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
M013TW_RS07155	COG0116	Belongs to the methyltransferase superfamily
M013TW_RS07195	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M013TW_RS07195	COG4499	WXG100 protein secretion system (Wss), protein YukC
M013TW_RS07205	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M013TW_RS07210	COG3935	DnaD domain protein
M013TW_RS07235	COG0438	transferase activity, transferring glycosyl groups
M013TW_RS07240	COG1694	Mazg nucleotide pyrophosphohydrolase
M013TW_RS07245	COG2738	Putative neutral zinc metallopeptidase
M013TW_RS07250	COG4347	Protein of unknown function (DUF1405)
M013TW_RS07290	COG0142	geranyltranstransferase activity
M013TW_RS07345	COG0492	ferredoxin-NADP+ reductase activity
M013TW_RS07360	COG0514	ATP-dependent DNA helicase (RecQ)
M013TW_RS07370	COG1141	Ferredoxin
M013TW_RS07405	COG0860	N-Acetylmuramoyl-L-alanine amidase
M013TW_RS07405	COG1388	LysM domain
M013TW_RS07490	COG0740	serine-type endopeptidase activity
M013TW_RS07595	COG1484	DNA-dependent DNA replication
M013TW_RS07615	COG0629	single-stranded DNA binding
M013TW_RS07725	COG0582	viral genome integration into host DNA
M013TW_RS07740	COG5002	protein histidine kinase activity
M013TW_RS07745	COG0745	RESPONSE REGULATOR receiver
M013TW_RS07750	COG1187	pseudouridine synthase activity
M013TW_RS07775	COG0735	belongs to the Fur family
M013TW_RS07780	COG0494	nUDIX hydrolase
M013TW_RS07785	COG0667	Aldo Keto reductase
M013TW_RS07795	COG4221	oxidoreductase activity
M013TW_RS07810	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M013TW_RS07820	COG0366	Alpha amylase catalytic
M013TW_RS07825	COG1609	Transcriptional regulator
M013TW_RS07845	COG2195	Cleaves the N-terminal amino acid of tripeptides
M013TW_RS07855	COG4129	membrane
M013TW_RS07865	COG0508	dehydrogenase complex catalyzes the overall conversion of
M013TW_RS07870	COG0022	dehydrogenase e1 component
M013TW_RS07875	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M013TW_RS07880	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M013TW_RS07885	COG0497	DNA recombination
M013TW_RS07915	COG1302	Protein conserved in bacteria
M013TW_RS07920	COG0439	Biotin carboxylase
M013TW_RS07925	COG0511	ligase activity, forming carbon-carbon bonds
M013TW_RS07935	COG0006	proline dipeptidase activity
M013TW_RS07950	COG0095	Lipoate-protein ligase
M013TW_RS07955	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M013TW_RS08000	COG4537	Required for transformation and DNA binding
M013TW_RS08005	COG1459	type II secretion system
M013TW_RS08010	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M013TW_RS08015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M013TW_RS08020	COG0011	TIGRFAM Protein of
M013TW_RS08025	COG1940	carbohydrate kinase activity
M013TW_RS08030	COG4483	Protein conserved in bacteria
M013TW_RS08040	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M013TW_RS08050	COG0768	penicillin binding
M013TW_RS08065	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M013TW_RS08070	COG1121	(ABC) transporter
M013TW_RS08080	COG0513	Belongs to the DEAD box helicase family
M013TW_RS08090	COG2384	SAM-dependent methyltransferase
M013TW_RS08110	COG0517	IMP dehydrogenase activity
M013TW_RS08130	COG0295	cytidine deaminase activity
M013TW_RS08135	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M013TW_RS08145	COG1702	phosphate starvation-inducible protein PhoH
M013TW_RS08160	COG1030	water channel activity
M013TW_RS08170	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M013TW_RS08175	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M013TW_RS08205	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M013TW_RS08220	COG1466	dna polymerase III delta subunit
M013TW_RS08225	COG0658	competence protein
M013TW_RS08225	COG2333	competence protein COMEC
M013TW_RS08230	COG2131	deaminase
M013TW_RS08240	COG2226	methyltransferase
M013TW_RS08245	COG0799	negative regulation of ribosome biogenesis
M013TW_RS08250	COG1713	HD superfamily hydrolase involved in NAD metabolism
M013TW_RS08260	COG1534	Rna-binding protein
M013TW_RS08270	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M013TW_RS08275	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
M013TW_RS08305	COG3177	Filamentation induced by cAMP protein fic
M013TW_RS08310	COG1914	H( )-stimulated, divalent metal cation uptake system
M013TW_RS08320	COG0439	Biotin carboxylase
M013TW_RS08325	COG0511	ligase activity, forming carbon-carbon bonds
M013TW_RS08330	COG1984	allophanate hydrolase subunit 2
M013TW_RS08335	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
M013TW_RS08350	COG0826	peptidase U32
M013TW_RS08355	COG0826	peptidase U32
M013TW_RS08385	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M013TW_RS08400	COG1104	cysteine desulfurase activity
M013TW_RS08405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M013TW_RS08415	COG3237	CsbD-like
M013TW_RS08420	COG1959	2 iron, 2 sulfur cluster binding
M013TW_RS08425	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M013TW_RS08430	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M013TW_RS08475	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M013TW_RS08475	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
M013TW_RS08480	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M013TW_RS08480	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M013TW_RS08485	COG1862	Preprotein translocase
M013TW_RS08525	COG2868	ribosomal protein
M013TW_RS08570	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M013TW_RS08575	COG0285	dihydrofolate synthase activity
M013TW_RS08585	COG2818	Glycosylase
M013TW_RS08620	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M013TW_RS08655	COG4112	unkown
M013TW_RS08675	COG0833	amino acid
M013TW_RS08690	COG1484	DNA-dependent DNA replication
M013TW_RS08720	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M013TW_RS08720	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M013TW_RS08730	COG5002	protein histidine kinase activity
M013TW_RS08735	COG0745	RESPONSE REGULATOR receiver
M013TW_RS08745	COG0372	Belongs to the citrate synthase family
M013TW_RS08750	COG1113	amino acid transport
M013TW_RS08775	COG0281	malic enzyme
M013TW_RS08785	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M013TW_RS08790	COG4109	DRTGG domain
M013TW_RS08830	COG0827	DNA restriction-modification system
M013TW_RS08840	COG0730	response to heat
M013TW_RS08850	COG1104	cysteine desulfurase activity
M013TW_RS08860	COG1956	GAF domain-containing protein
M013TW_RS08875	COG0584	glycerophosphoryl diester phosphodiesterase
M013TW_RS08880	COG1764	response to oxidative stress
M013TW_RS08885	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M013TW_RS08890	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M013TW_RS08910	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M013TW_RS08910	COG1263	PTS System
M013TW_RS08915	COG0204	Acyl-transferase
M013TW_RS08920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M013TW_RS08955	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M013TW_RS08960	COG0454	-acetyltransferase
M013TW_RS08980	COG1605	Chorismate mutase
M013TW_RS08980	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
M013TW_RS09005	COG1674	ftsk spoiiie
M013TW_RS09010	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M013TW_RS09020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M013TW_RS09025	COG1363	Peptidase, m42
M013TW_RS09035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M013TW_RS09045	COG0510	thiamine kinase activity
M013TW_RS09065	COG1187	pseudouridine synthase activity
M013TW_RS09070	COG2244	polysaccharide biosynthetic process
M013TW_RS09095	COG2814	Major facilitator Superfamily
M013TW_RS09100	COG1242	4 iron, 4 sulfur cluster binding
M013TW_RS09105	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
M013TW_RS09115	COG2267	carboxylic ester hydrolase activity
M013TW_RS09150	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M013TW_RS09150	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M013TW_RS09175	COG5632	N-Acetylmuramoyl-L-alanine amidase
M013TW_RS09175	COG3266	domain, Protein
M013TW_RS09175	COG4193	domain, Protein
M013TW_RS09210	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M013TW_RS09230	COG0656	L-ascorbic acid biosynthetic process
M013TW_RS09250	COG1506	peptidase
M013TW_RS09255	COG2816	NAD+ diphosphatase activity
M013TW_RS09355	COG0860	N-Acetylmuramoyl-L-alanine amidase
M013TW_RS09355	COG1388	LysM domain
M013TW_RS09440	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
M013TW_RS09470	COG1131	(ABC) transporter
M013TW_RS09475	COG0537	adenosine 5'-monophosphoramidase activity
M013TW_RS09510	COG0420	3'-5' exonuclease activity
M013TW_RS09535	COG2197	response regulator
M013TW_RS09540	COG4585	Histidine kinase
M013TW_RS09540	COG2203	Gaf domain
M013TW_RS09545	COG0564	pseudouridine synthase activity
M013TW_RS09580	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M013TW_RS09585	COG1126	abc transporter atp-binding protein
M013TW_RS09590	COG0765	amino acid transport
M013TW_RS09760	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M013TW_RS09765	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M013TW_RS09775	COG4129	membrane
M013TW_RS09790	COG1194	a g-specific adenine glycosylase
M013TW_RS09795	COG1988	membrane-bound metal-dependent
M013TW_RS09810	COG1134	teichoic acid transport
M013TW_RS09810	COG1388	LysM domain
M013TW_RS09840	COG0535	radical SAM domain protein
M013TW_RS09845	COG1607	acyl-coa hydrolase
M013TW_RS09850	COG2309	aminopeptidase activity
M013TW_RS09870	COG1295	ribonuclease BN
M013TW_RS09990	COG4851	CamS sex pheromone cAM373 precursor
M013TW_RS10010	COG4496	protein, YerC YecD
M013TW_RS10050	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M013TW_RS10060	COG0077	Prephenate dehydratase
M013TW_RS10070	COG0471	metal ion transport
M013TW_RS10080	COG1335	isochorismatase
M013TW_RS10095	COG1012	belongs to the aldehyde dehydrogenase family
M013TW_RS10145	COG1131	(ABC) transporter
M013TW_RS10160	COG1725	Transcriptional regulator
M013TW_RS10210	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M013TW_RS10275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M013TW_RS10280	COG1621	beta-fructofuranosidase activity
M013TW_RS10285	COG1609	Transcriptional regulator
M013TW_RS10290	COG0004	ammonium transporteR
M013TW_RS10295	COG0425	Belongs to the sulfur carrier protein TusA family
M013TW_RS10300	COG2391	methyltransferase activity
M013TW_RS10310	COG0488	(ABC) transporter
M013TW_RS10325	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
M013TW_RS10335	COG0456	acetyltransferase
M013TW_RS10340	COG1214	PFAM Peptidase M22, glycoprotease
M013TW_RS10345	COG0802	atpase or kinase
M013TW_RS10360	COG0028	Belongs to the TPP enzyme family
M013TW_RS10435	COG2183	response to ionizing radiation
M013TW_RS10440	COG1191	sigma factor activity
M013TW_RS10450	COG1366	Belongs to the anti-sigma-factor antagonist family
M013TW_RS10455	COG2208	phosphoserine phosphatase activity
M013TW_RS10485	COG3428	Bacterial PH domain
M013TW_RS10515	COG2205	protein histidine kinase activity
M013TW_RS10520	COG0745	RESPONSE REGULATOR receiver
M013TW_RS10530	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M013TW_RS10540	COG0772	Belongs to the SEDS family
M013TW_RS10555	COG1937	Protein conserved in bacteria
M013TW_RS10565	COG1418	mRNA catabolic process
M013TW_RS10620	COG0629	single-stranded DNA binding
M013TW_RS10710	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M013TW_RS10735	COG0009	L-threonylcarbamoyladenylate synthase
M013TW_RS10740	COG2890	protein-(glutamine-N5) methyltransferase activity
M013TW_RS10765	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M013TW_RS10805	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M013TW_RS10850	COG0813	purine-nucleoside phosphorylase activity
M013TW_RS10855	COG0783	Belongs to the Dps family
M013TW_RS10875	COG1482	cell wall glycoprotein biosynthetic process
M013TW_RS10880	COG0702	epimerase
M013TW_RS10885	COG0640	Transcriptional regulator
M013TW_RS10920	COG0561	phosphatase activity
M013TW_RS10925	COG1119	ATPase activity
M013TW_RS10940	COG3711	transcriptional antiterminator
M013TW_RS10970	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
M013TW_RS11030	COG0489	protein tyrosine kinase activity
M013TW_RS11035	COG2814	Major facilitator Superfamily
M013TW_RS11055	COG1272	protein, Hemolysin III
M013TW_RS11065	COG1988	membrane-bound metal-dependent
M013TW_RS11075	COG3314	Sporulation integral membrane protein YlbJ
M013TW_RS11080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M013TW_RS11085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M013TW_RS11090	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
M013TW_RS11100	COG3457	Alanine racemase
M013TW_RS11105	COG4264	IucA IucC family
M013TW_RS11110	COG2814	Major facilitator Superfamily
M013TW_RS11135	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M013TW_RS11145	COG2130	NADP-dependent
M013TW_RS11205	COG0656	L-ascorbic acid biosynthetic process
M013TW_RS11210	COG0789	Transcriptional regulator
M013TW_RS11220	COG5492	domain, Protein
M013TW_RS11225	COG2378	regulation of single-species biofilm formation
M013TW_RS11230	COG0693	protein deglycase activity
M013TW_RS11240	COG3527	Alpha-acetolactate decarboxylase
M013TW_RS11245	COG0028	Belongs to the TPP enzyme family
M013TW_RS11335	COG0201	protein transport
M013TW_RS11450	COG2252	PERMEase
M013TW_RS11495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M013TW_RS11555	COG1763	Mo-molybdopterin cofactor biosynthetic process
M013TW_RS11575	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M013TW_RS11580	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
M013TW_RS11585	COG4149	molybdate abc transporter
M013TW_RS11590	COG0725	ABC transporter, periplasmic molybdate-binding protein
M013TW_RS11605	COG1268	BioY protein
M013TW_RS11620	COG1960	acyl-CoA dehydrogenase activity
M013TW_RS11625	COG4413	Urea transporter
M013TW_RS11695	COG1757	Na H antiporter
M013TW_RS11710	COG3942	CHAP domain
M013TW_RS11750	COG1316	TRANSCRIPTIONal
M013TW_RS11780	COG1113	amino acid transport
M013TW_RS11800	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M013TW_RS11805	COG0385	Bile acid
M013TW_RS11815	COG1263	PTS System
M013TW_RS11815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M013TW_RS11820	COG1737	Transcriptional regulator
M013TW_RS11840	COG1028	Short-chain dehydrogenase reductase Sdr
M013TW_RS11845	COG1473	amidohydrolase
M013TW_RS11860	COG0583	DNA-binding transcription factor activity
M013TW_RS11880	COG2258	MOSC domain
M013TW_RS11900	COG1668	transmembrane transport
M013TW_RS11905	COG4152	abc transporter atp-binding protein
M013TW_RS11910	COG3152	Membrane
M013TW_RS11925	COG0786	glutamate:sodium symporter activity
M013TW_RS11935	COG0598	Magnesium transport protein CorA
M013TW_RS11950	COG0657	acetylesterase activity
M013TW_RS11960	COG2814	Major facilitator Superfamily
M013TW_RS11965	COG1566	PFAM secretion protein HlyD family protein
M013TW_RS11980	COG2814	Major facilitator Superfamily
M013TW_RS12040	COG1131	(ABC) transporter
M013TW_RS12055	COG1620	l-lactate permease
M013TW_RS12075	COG0604	alcohol dehydrogenase
M013TW_RS12100	COG1511	domain protein
M013TW_RS12115	COG1263	PTS System
M013TW_RS12115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M013TW_RS12130	COG3871	stress protein (general stress protein 26)
M013TW_RS12170	COG0789	Transcriptional regulator
M013TW_RS12190	COG2181	nitrate reductase activity
M013TW_RS12200	COG1140	nitrate reductase beta subunit
M013TW_RS12205	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
M013TW_RS12215	COG2146	nitrite reductase [NAD(P)H] activity
M013TW_RS12220	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M013TW_RS12230	COG0454	-acetyltransferase
M013TW_RS12235	COG2116	formate transmembrane transporter activity
M013TW_RS12250	COG0803	Belongs to the bacterial solute-binding protein 9 family
M013TW_RS12250	COG3443	Belongs to the bacterial solute-binding protein 9 family
M013TW_RS12285	COG1126	abc transporter atp-binding protein
M013TW_RS12290	COG0765	amino acid transport
M013TW_RS12295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M013TW_RS12300	COG2814	Major facilitator Superfamily
M013TW_RS12315	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M013TW_RS12360	COG0156	8-amino-7-oxononanoate synthase activity
M013TW_RS12370	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M013TW_RS12375	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
M013TW_RS12385	COG1132	(ABC) transporter
M013TW_RS12390	COG1132	(ABC) transporter
M013TW_RS12390	COG2375	cellular response to nickel ion
M013TW_RS12405	COG1929	Belongs to the glycerate kinase type-1 family
M013TW_RS12415	COG2814	Major facilitator Superfamily
M013TW_RS12430	COG1408	metallophosphoesterase
M013TW_RS12435	COG1113	amino acid transport
M013TW_RS12445	COG0531	amino acid
M013TW_RS12460	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M013TW_RS12470	COG1174	glycine betaine transport
M013TW_RS12480	COG1174	glycine betaine transport
M013TW_RS12500	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
M013TW_RS12505	COG0531	amino acid
M013TW_RS12510	COG2272	Belongs to the type-B carboxylesterase lipase family
M013TW_RS12515	COG2814	Major facilitator Superfamily
M013TW_RS12520	COG0390	transport system, permease component
M013TW_RS12525	COG4619	ABC transporter
M013TW_RS12530	COG1363	Peptidase, m42
M013TW_RS12535	COG4808	Protein conserved in bacteria
M013TW_RS12540	COG0069	glutamate synthase activity
M013TW_RS12555	COG1124	(ABC) transporter
M013TW_RS12565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M013TW_RS12570	COG0601	transmembrane transport
M013TW_RS12575	COG0747	negative chemotaxis
M013TW_RS12600	COG1028	Short-chain dehydrogenase reductase Sdr
M013TW_RS12605	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
M013TW_RS12610	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M013TW_RS12710	COG0494	nUDIX hydrolase
M013TW_RS12750	COG1846	Transcriptional regulator
M013TW_RS12785	COG1070	Carbohydrate kinase
M013TW_RS12790	COG1802	Transcriptional regulator
M013TW_RS12795	COG0789	Transcriptional regulator
M013TW_RS12800	COG2357	RelA SpoT domain protein
M013TW_RS12805	COG4876	unkown
M013TW_RS12820	COG2271	Major facilitator Superfamily
M013TW_RS12825	COG0586	Pfam SNARE associated Golgi protein
M013TW_RS12845	COG1131	(ABC) transporter
M013TW_RS12855	COG1073	alpha beta
M013TW_RS12865	COG1073	alpha beta
M013TW_RS12895	COG0400	carboxylic ester hydrolase activity
M013TW_RS12900	COG0346	lactoylglutathione lyase activity
M013TW_RS12905	COG1846	Transcriptional regulator
M013TW_RS12920	COG2514	catechol 2,3-dioxygenase activity
M013TW_RS12935	COG0561	phosphatase activity
M013TW_RS12940	COG1131	(ABC) transporter
M013TW_RS12950	COG3764	Sortase (surface protein transpeptidase)
M013TW_RS12970	COG1760	l-serine dehydratase
M013TW_RS12975	COG1760	l-serine dehydratase
M013TW_RS12990	COG0697	spore germination
M013TW_RS12995	COG0657	acetylesterase activity
M013TW_RS13015	COG0028	Belongs to the TPP enzyme family
M013TW_RS13030	COG0583	DNA-binding transcription factor activity
M013TW_RS13040	COG3942	CHAP domain
M013TW_RS13050	COG3425	synthase
M013TW_RS13060	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M013TW_RS13085	COG2409	Drug exporters of the RND superfamily
M013TW_RS13130	COG0436	Aminotransferase
M013TW_RS13170	COG0456	acetyltransferase
M013TW_RS13235	COG0596	Alpha beta hydrolase
M013TW_RS13270	COG3001	Fructosamine kinase
M013TW_RS13275	COG0167	dihydroorotate dehydrogenase activity
M013TW_RS13340	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M013TW_RS13345	COG3527	Alpha-acetolactate decarboxylase
M013TW_RS13355	COG0531	amino acid
M013TW_RS13385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M013TW_RS13405	COG1012	belongs to the aldehyde dehydrogenase family
M013TW_RS13415	COG1510	regulation of RNA biosynthetic process
M013TW_RS13420	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M013TW_RS13445	COG2851	Citrate transporter
M013TW_RS13455	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M013TW_RS13465	COG0386	Belongs to the glutathione peroxidase family
M013TW_RS13490	COG1136	(ABC) transporter
M013TW_RS13495	COG2205	protein histidine kinase activity
M013TW_RS13500	COG0745	RESPONSE REGULATOR receiver
M013TW_RS13510	COG1785	Belongs to the alkaline phosphatase family
M013TW_RS13520	COG1846	Transcriptional regulator
M013TW_RS13565	COG1438	arginine binding
M013TW_RS13585	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M013TW_RS13585	COG3711	transcriptional antiterminator
M013TW_RS13590	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M013TW_RS13590	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M013TW_RS13590	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M013TW_RS13595	COG1482	cell wall glycoprotein biosynthetic process
M013TW_RS13605	COG3942	CHAP domain
M013TW_RS13605	COG1705	Flagellar rod assembly protein muramidase FlgJ
M013TW_RS13610	COG1535	isochorismatase
M013TW_RS13610	COG3433	isochorismatase activity
M013TW_RS13625	COG0438	transferase activity, transferring glycosyl groups
M013TW_RS13640	COG1073	alpha beta
M013TW_RS13660	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M013TW_RS13690	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M013TW_RS13785	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M013TW_RS13870	COG0471	metal ion transport
M013TW_RS13875	COG2962	Rard protein
M013TW_RS13885	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
M013TW_RS13900	COG1136	(ABC) transporter
M013TW_RS13905	COG0577	efflux transmembrane transporter activity
M013TW_RS13940	COG1278	Cold shock
M013TW_RS13960	COG1475	DNA binding
M013TW_RS14040	COG0583	DNA-binding transcription factor activity
M013TW_RS14060	COG1846	Transcriptional regulator
M013TW_RS14100	COG0659	secondary active sulfate transmembrane transporter activity
M013TW_RS14105	COG0589	response to stress