locus-tag	class	description
MW_RS00015	COG2501	S4 domain
MW_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MW_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MW_RS00060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MW_RS00070	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
MW_RS00080	COG0305	Participates in initiation and elongation during chromosome replication
MW_RS00110	COG4863	YycH protein
MW_RS00120	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MW_RS00125	COG0737	Belongs to the 5'-nucleotidase family
MW_RS00155	COG0584	glycerophosphoryl diester phosphodiesterase
MW_RS00160	COG2030	dehydratase
MW_RS00230	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MW_RS00235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MW_RS00270	COG0456	acetyltransferase
MW_RS00285	COG0730	response to heat
MW_RS00290	COG1937	Protein conserved in bacteria
MW_RS00295	COG2210	Belongs to the sulfur carrier protein TusA family
MW_RS00300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MW_RS00335	COG0655	NAD(P)H dehydrogenase (quinone) activity
MW_RS00350	COG0583	DNA-binding transcription factor activity
MW_RS00370	COG0823	Involved in the tonB-independent uptake of proteins
MW_RS00410	COG1473	amidohydrolase
MW_RS00420	COG1283	sodium-dependent phosphate transmembrane transporter activity
MW_RS00425	COG4716	Myosin-crossreactive antigen
MW_RS00435	COG1620	l-lactate permease
MW_RS00450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MW_RS00455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MW_RS00460	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MW_RS00470	COG2423	ornithine cyclodeaminase activity
MW_RS00475	COG4264	IucA IucC family
MW_RS00480	COG2814	Major facilitator Superfamily
MW_RS00485	COG4264	IucA IucC family
MW_RS00490	COG4264	IucA IucC family
MW_RS00500	COG0019	diaminopimelate decarboxylase activity
MW_RS00505	COG1475	DNA binding
MW_RS00535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MW_RS00540	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MW_RS00545	COG0438	transferase activity, transferring glycosyl groups
MW_RS00580	COG0813	purine-nucleoside phosphorylase activity
MW_RS00585	COG2814	Major facilitator Superfamily
MW_RS00605	COG3639	organic phosphonate transmembrane transporter activity
MW_RS00625	COG0737	Belongs to the 5'-nucleotidase family
MW_RS00655	COG1454	alcohol dehydrogenase
MW_RS00655	COG1012	belongs to the aldehyde dehydrogenase family
MW_RS00680	COG1086	Polysaccharide biosynthesis protein
MW_RS00690	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MW_RS00720	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MW_RS00730	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
MW_RS00735	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MW_RS00745	COG2832	Protein of unknown function (DUF454)
MW_RS00780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MW_RS00785	COG1960	acyl-CoA dehydrogenase activity
MW_RS00790	COG5609	conserved protein (DUF2294)
MW_RS00840	COG1114	Component of the transport system for branched-chain amino acids
MW_RS00845	COG1335	isochorismatase
MW_RS00850	COG3961	Belongs to the TPP enzyme family
MW_RS00880	COG1737	Transcriptional regulator
MW_RS00905	COG1136	(ABC) transporter
MW_RS00915	COG0577	efflux transmembrane transporter activity
MW_RS00915	COG1136	(ABC) transporter
MW_RS00935	COG1131	(ABC) transporter
MW_RS00950	COG0601	transmembrane transport
MW_RS00955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MW_RS00965	COG0405	Gamma-glutamyltransferase
MW_RS00985	COG3842	ATPase activity
MW_RS00995	COG1175	transmembrane transport
MW_RS01000	COG3833	ABC-type maltose transport systems, permease component
MW_RS01005	COG0673	inositol 2-dehydrogenase activity
MW_RS01010	COG0673	inositol 2-dehydrogenase activity
MW_RS01020	COG1755	Isoprenylcysteine carboxyl methyltransferase
MW_RS01085	COG0183	Belongs to the thiolase family
MW_RS01095	COG1960	acyl-CoA dehydrogenase activity
MW_RS01100	COG0318	PFAM AMP-dependent synthetase and ligase
MW_RS01115	COG0747	negative chemotaxis
MW_RS01120	COG3189	MarR family transcriptional regulator
MW_RS01150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MW_RS01150	COG1263	PTS System
MW_RS01150	COG2190	(PTS) system
MW_RS01155	COG1957	nucleoside hydrolase
MW_RS01170	COG3414	Phosphotransferase system galactitol-specific IIB component
MW_RS01175	COG3775	system Galactitol-specific IIC component
MW_RS01180	COG1063	alcohol dehydrogenase
MW_RS01190	COG1063	alcohol dehydrogenase
MW_RS01200	COG1063	alcohol dehydrogenase
MW_RS01205	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MW_RS01215	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MW_RS01225	COG1063	alcohol dehydrogenase
MW_RS01230	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MW_RS01265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MW_RS01270	COG1263	PTS System
MW_RS01270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MW_RS01270	COG2190	(PTS) system
MW_RS01275	COG2723	6-phospho-beta-galactosidase activity
MW_RS01285	COG2226	methyltransferase
MW_RS01340	COG1131	(ABC) transporter
MW_RS01360	COG1388	LysM domain
MW_RS01360	COG3942	CHAP domain
MW_RS01490	COG1114	Component of the transport system for branched-chain amino acids
MW_RS01495	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
MW_RS01505	COG0577	efflux transmembrane transporter activity
MW_RS01530	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MW_RS01535	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MW_RS01560	COG3314	Sporulation integral membrane protein YlbJ
MW_RS01585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MW_RS01615	COG3037	sugar-specific permease SgaT UlaA
MW_RS01625	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MW_RS01630	COG3711	transcriptional antiterminator
MW_RS01650	COG2271	Major facilitator Superfamily
MW_RS01655	COG0346	lactoylglutathione lyase activity
MW_RS01660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MW_RS01665	COG0431	NADPH-dependent FMN reductase
MW_RS01675	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MW_RS01690	COG0672	)-iron permease
MW_RS01695	COG0805	protein transport
MW_RS01700	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MW_RS01710	COG1476	TRANSCRIPTIONal
MW_RS01720	COG1131	(ABC) transporter
MW_RS01755	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MW_RS01755	COG0646	methionine synthase
MW_RS01760	COG0626	cystathionine gamma-synthase activity
MW_RS01765	COG0626	cystathionine gamma-synthase activity
MW_RS01770	COG1475	DNA binding
MW_RS01775	COG0668	transmembrane transport
MW_RS01780	COG4481	Protein conserved in bacteria
MW_RS01785	COG0012	GTP binding
MW_RS01885	COG1823	symporter activity
MW_RS01915	COG2233	PERMEase
MW_RS01990	COG1683	Conserved Protein
MW_RS02000	COG3759	membrane
MW_RS02145	COG0523	cobalamin synthesis protein
MW_RS02155	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MW_RS02165	COG5609	conserved protein (DUF2294)
MW_RS02180	COG1647	Serine aminopeptidase, S33
MW_RS02190	COG0733	neurotransmitter:sodium symporter activity
MW_RS02195	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MW_RS02200	COG0626	cystathionine gamma-synthase activity
MW_RS02210	COG2011	ABC-type metal ion transport system permease component
MW_RS02215	COG1464	Belongs to the NlpA lipoprotein family
MW_RS02250	COG0583	DNA-binding transcription factor activity
MW_RS02255	COG0067	glutamate synthase
MW_RS02255	COG0070	glutamate synthase
MW_RS02255	COG0069	glutamate synthase activity
MW_RS02260	COG0493	'glutamate synthase
MW_RS02270	COG1263	PTS System
MW_RS02270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MW_RS02275	COG0366	Alpha amylase catalytic
MW_RS02280	COG2188	Transcriptional regulator
MW_RS02295	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MW_RS02330	COG1982	Orn Lys Arg decarboxylase major
MW_RS02340	COG3870	Protein conserved in bacteria
MW_RS02350	COG0470	DNA polymerase III
MW_RS02355	COG1774	PSP1 C-terminal conserved region
MW_RS02365	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MW_RS02375	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MW_RS02390	COG0084	hydrolase, TatD family'
MW_RS02395	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
MW_RS02405	COG4466	Protein conserved in bacteria
MW_RS02415	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MW_RS02420	COG0251	oxidation-reduction process
MW_RS02465	COG2244	polysaccharide biosynthetic process
MW_RS02470	COG3956	TIGRFAM MazG family protein
MW_RS02475	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MW_RS02485	COG1098	S1 RNA binding domain
MW_RS02500	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MW_RS02525	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MW_RS02620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MW_RS02635	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MW_RS02645	COG3880	PFAM UvrB UvrC protein
MW_RS02665	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MW_RS02670	COG4956	integral membrane protein (PIN domain superfamily)
MW_RS02690	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
MW_RS02740	COG2813	Specifically methylates the guanine in position
MW_RS02780	COG1473	amidohydrolase
MW_RS02810	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MW_RS02815	COG1428	Deoxynucleoside kinase
MW_RS02820	COG1428	Deoxynucleoside kinase
MW_RS02830	COG0561	phosphatase activity
MW_RS02870	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MW_RS02975	COG0095	Lipoate-protein ligase
MW_RS02980	COG0083	homoserine kinase activity
MW_RS03000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MW_RS03085	COG0667	Aldo Keto reductase
MW_RS03090	COG0655	NAD(P)H dehydrogenase (quinone) activity
MW_RS03100	COG1078	dGTPase activity
MW_RS03135	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MW_RS03140	COG4139	cobalamin transport
MW_RS03190	COG4974	Belongs to the 'phage' integrase family
MW_RS03235	COG0803	Belongs to the bacterial solute-binding protein 9 family
MW_RS03240	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MW_RS03245	COG1121	(ABC) transporter
MW_RS03250	COG1321	iron dependent repressor
MW_RS03270	COG1682	transport, permease protein
MW_RS03275	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MW_RS03285	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MW_RS03290	COG1686	Belongs to the peptidase S11 family
MW_RS03295	COG1132	(ABC) transporter
MW_RS03300	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MW_RS03310	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MW_RS03315	COG1120	ATPase activity
MW_RS03320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MW_RS03325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MW_RS03330	COG2376	Dihydroxyacetone kinase
MW_RS03340	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
MW_RS03350	COG3949	Membrane
MW_RS03375	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MW_RS03390	COG1136	(ABC) transporter
MW_RS03395	COG0577	efflux transmembrane transporter activity
MW_RS03400	COG1392	Phosphate transport regulator
MW_RS03405	COG0306	phosphate transporter
MW_RS03410	COG3942	CHAP domain
MW_RS03410	COG1388	LysM domain
MW_RS03420	COG1917	Cupin 2, conserved barrel domain protein
MW_RS03420	COG4977	sequence-specific DNA binding
MW_RS03450	COG0583	DNA-binding transcription factor activity
MW_RS03460	COG2814	Major facilitator Superfamily
MW_RS03465	COG2839	Protein conserved in bacteria
MW_RS03495	COG1611	Belongs to the LOG family
MW_RS03515	COG4988	ABC transporter
MW_RS03520	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MW_RS03535	COG4989	oxidoreductase activity
MW_RS03545	COG0471	metal ion transport
MW_RS03550	COG0415	Belongs to the DNA photolyase family
MW_RS03580	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MW_RS03585	COG1349	DNA-binding transcription factor activity
MW_RS03590	COG1105	Belongs to the carbohydrate kinase PfkB family
MW_RS03595	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MW_RS03595	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MW_RS03595	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MW_RS03605	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MW_RS03610	COG1253	flavin adenine dinucleotide binding
MW_RS03615	COG0656	L-ascorbic acid biosynthetic process
MW_RS03620	COG0463	Glycosyl transferase, family 2
MW_RS03655	COG0720	synthase
MW_RS03665	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MW_RS03665	COG0512	Glutamine amidotransferase of anthranilate synthase
MW_RS03670	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MW_RS03705	COG0488	(ABC) transporter
MW_RS03710	COG0514	ATP-dependent DNA helicase (RecQ)
MW_RS03715	COG1125	glycine betaine transport
MW_RS03715	COG0517	IMP dehydrogenase activity
MW_RS03720	COG1174	glycine betaine transport
MW_RS03750	COG3104	oligopeptide transport
MW_RS03770	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MW_RS03775	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MW_RS03790	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MW_RS03795	COG4605	iron ion homeostasis
MW_RS03800	COG4604	ABC transporter, ATP-binding protein
MW_RS03805	COG4607	ABC-type enterochelin transport system periplasmic component
MW_RS03860	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MW_RS03865	COG1739	Uncharacterized protein family UPF0029
MW_RS03875	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
MW_RS03880	COG1040	competence protein
MW_RS03910	COG3942	CHAP domain
MW_RS03910	COG1388	LysM domain
MW_RS03970	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MW_RS04035	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MW_RS04040	COG1647	Serine aminopeptidase, S33
MW_RS04045	COG0557	exoribonuclease II activity
MW_RS04060	COG0582	viral genome integration into host DNA
MW_RS04180	COG1278	Cold shock
MW_RS04220	COG0406	alpha-ribazole phosphatase activity
MW_RS04225	COG1279	arginine transmembrane transporter activity
MW_RS04250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MW_RS04255	COG1393	Belongs to the ArsC family
MW_RS04270	COG3878	Protein conserved in bacteria
MW_RS04275	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
MW_RS04290	COG2011	ABC-type metal ion transport system permease component
MW_RS04295	COG1464	Belongs to the NlpA lipoprotein family
MW_RS04310	COG0396	ATPase activity
MW_RS04315	COG0719	Fe-S assembly protein
MW_RS04325	COG0822	iron-sulfur transferase activity
MW_RS04345	COG1253	flavin adenine dinucleotide binding
MW_RS04355	COG1801	Protein of unknown function DUF72
MW_RS04360	COG0730	response to heat
MW_RS04375	COG4470	Protein conserved in bacteria
MW_RS04385	COG2445	Protein of unknown function DUF86
MW_RS04415	COG1696	Membrane protein involved in D-alanine export
MW_RS04425	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
MW_RS04430	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
MW_RS04435	COG4837	Protein of unknown function (DUF1462)
MW_RS04440	COG1252	NADH dehydrogenase
MW_RS04450	COG0316	Belongs to the HesB IscA family
MW_RS04460	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MW_RS04465	COG2056	Na+-H+ antiporter family
MW_RS04470	COG2050	protein possibly involved in aromatic compounds catabolism
MW_RS04525	COG1098	S1 RNA binding domain
MW_RS04530	COG1902	pentaerythritol trinitrate reductase activity
MW_RS04545	COG0584	glycerophosphoryl diester phosphodiesterase
MW_RS04565	COG0398	Pfam SNARE associated Golgi protein
MW_RS04605	COG0561	phosphatase activity
MW_RS04630	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MW_RS04645	COG1881	PFAM PEBP family protein
MW_RS04675	COG0601	transmembrane transport
MW_RS04680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MW_RS04685	COG0444	Belongs to the ABC transporter superfamily
MW_RS04690	COG4608	Belongs to the ABC transporter superfamily
MW_RS04695	COG4166	transmembrane transport
MW_RS04700	COG0747	negative chemotaxis
MW_RS04705	COG0444	Belongs to the ABC transporter superfamily
MW_RS04710	COG4608	Belongs to the ABC transporter superfamily
MW_RS04715	COG0601	transmembrane transport
MW_RS04720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MW_RS04745	COG1164	Oligoendopeptidase f
MW_RS04755	COG2346	COG2346, Truncated hemoglobins
MW_RS04770	COG2357	RelA SpoT domain protein
MW_RS04780	COG0564	pseudouridine synthase activity
MW_RS04785	COG2239	Acts as a magnesium transporter
MW_RS04790	COG0569	domain protein
MW_RS04790	COG0475	glutathione-regulated potassium exporter activity
MW_RS04800	COG0628	permease
MW_RS04805	COG1115	amino acid carrier protein
MW_RS04845	COG0861	Integral membrane protein TerC family
MW_RS04855	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MW_RS04860	COG0737	Belongs to the 5'-nucleotidase family
MW_RS04875	COG4903	ComK protein
MW_RS04890	COG4873	Protein conserved in bacteria
MW_RS04950	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
MW_RS04960	COG2314	TM2 domain
MW_RS04965	COG0456	acetyltransferase
MW_RS04970	COG1575	Belongs to the MenA family. Type 1 subfamily
MW_RS04975	COG1169	isochorismate synthase
MW_RS04985	COG2267	carboxylic ester hydrolase activity
MW_RS05010	COG0436	Aminotransferase
MW_RS05015	COG3594	Acyltransferase
MW_RS05045	COG1316	TRANSCRIPTIONal
MW_RS05090	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MW_RS05105	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MW_RS05135	COG0138	bifunctional purine biosynthesis protein purh
MW_RS05145	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MW_RS05150	COG4172	Belongs to the ABC transporter superfamily
MW_RS05155	COG4721	ABC-type cobalt transport system, permease component
MW_RS05175	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MW_RS05195	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MW_RS05200	COG1271	oxidase subunit
MW_RS05205	COG1294	oxidase, subunit
MW_RS05210	COG0569	domain protein
MW_RS05280	COG1176	ABC-type spermidine putrescine transport system, permease component I
MW_RS05285	COG1177	transmembrane transport
MW_RS05290	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
MW_RS05315	COG0483	inositol monophosphate 1-phosphatase activity
MW_RS05325	COG1217	gtp-binding protein TYPA
MW_RS05335	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MW_RS05345	COG0772	Belongs to the SEDS family
MW_RS05380	COG3679	Belongs to the UPF0342 family
MW_RS05400	COG0742	ribosomal rna small subunit methyltransferase
MW_RS05460	COG4509	Sortase family
MW_RS05475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MW_RS05505	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MW_RS05505	COG1796	DNA polymerase
MW_RS05530	COG2009	succinate dehydrogenase
MW_RS05535	COG1053	succinate dehydrogenase
MW_RS05540	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MW_RS05665	COG1288	antiporter activity
MW_RS05700	COG1011	Hydrolase
MW_RS05725	COG4839	cell division protein FtsL
MW_RS05730	COG0768	penicillin binding
MW_RS05745	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MW_RS05765	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MW_RS05775	COG0762	integral membrane protein
MW_RS05780	COG2302	S4 RNA-binding domain
MW_RS05785	COG3599	regulation of cell shape
MW_RS05795	COG2514	catechol 2,3-dioxygenase activity
MW_RS05810	COG0564	pseudouridine synthase activity
MW_RS05820	COG2233	PERMEase
MW_RS05865	COG1293	RNA-binding protein homologous to eukaryotic snRNP
MW_RS05880	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MW_RS05885	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MW_RS05895	COG2314	TM2 domain
MW_RS05910	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MW_RS05910	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MW_RS05920	COG0631	protein serine/threonine phosphatase activity
MW_RS05935	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MW_RS05950	COG1302	Protein conserved in bacteria
MW_RS06000	COG1196	nuclear chromosome segregation
MW_RS06005	COG0552	protein localization to endoplasmic reticulum
MW_RS06015	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MW_RS06080	COG0758	DNA mediated transformation
MW_RS06175	COG0195	Participates in both transcription termination and antitermination
MW_RS06180	COG2740	Nucleic-acid-binding protein implicated in transcription termination
MW_RS06205	COG0196	riboflavin kinase activity
MW_RS06230	COG2188	Transcriptional regulator
MW_RS06235	COG0612	Peptidase, M16
MW_RS06240	COG0612	Peptidase, M16
MW_RS06245	COG0300	oxidoreductase activity
MW_RS06265	COG1546	Belongs to the CinA family
MW_RS06265	COG1058	Belongs to the CinA family
MW_RS06285	COG1692	metallophosphoesterase
MW_RS06290	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MW_RS06290	COG0674	pyruvate-flavodoxin oxidoreductase activity
MW_RS06295	COG1013	pyruvate-flavodoxin oxidoreductase activity
MW_RS06330	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
MW_RS06335	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MW_RS06360	COG1923	regulation of RNA biosynthetic process
MW_RS06370	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MW_RS06375	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
MW_RS06380	COG0789	Transcriptional regulator
MW_RS06475	COG1131	(ABC) transporter
MW_RS06490	COG2197	response regulator
MW_RS06500	COG1525	nuclease
MW_RS06515	COG0527	aspartate kinase activity
MW_RS06520	COG0460	homoserine dehydrogenase
MW_RS06525	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MW_RS06550	COG0833	amino acid
MW_RS06580	COG2340	Cysteine-rich secretory protein family
MW_RS06615	COG4846	Membrane protein involved in cytochrome C biogenesis
MW_RS06635	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MW_RS06650	COG0824	Thioesterase
MW_RS06680	COG1115	amino acid carrier protein
MW_RS06695	COG0628	permease
MW_RS06720	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MW_RS06730	COG1363	Peptidase, m42
MW_RS06735	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MW_RS06740	COG0512	Glutamine amidotransferase of anthranilate synthase
MW_RS06830	COG0704	Plays a role in the regulation of phosphate uptake
MW_RS06840	COG0581	inorganic phosphate transmembrane transporter activity
MW_RS06845	COG0573	inorganic phosphate transmembrane transporter activity
MW_RS06870	COG0488	(ABC) transporter
MW_RS06875	COG0527	aspartate kinase activity
MW_RS06880	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MW_RS06965	COG4548	von Willebrand factor, type A
MW_RS06970	COG0714	Associated with various cellular activities
MW_RS07010	COG0671	phosphoesterase, PA-phosphatase related
MW_RS07095	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
MW_RS07125	COG0531	amino acid
MW_RS07140	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MW_RS07145	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
MW_RS07170	COG0116	Belongs to the methyltransferase superfamily
MW_RS07200	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MW_RS07200	COG4499	WXG100 protein secretion system (Wss), protein YukC
MW_RS07210	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MW_RS07215	COG3935	DnaD domain protein
MW_RS07240	COG0438	transferase activity, transferring glycosyl groups
MW_RS07245	COG1694	Mazg nucleotide pyrophosphohydrolase
MW_RS07250	COG2738	Putative neutral zinc metallopeptidase
MW_RS07255	COG4347	Protein of unknown function (DUF1405)
MW_RS07295	COG0142	geranyltranstransferase activity
MW_RS07350	COG0492	ferredoxin-NADP+ reductase activity
MW_RS07365	COG0514	ATP-dependent DNA helicase (RecQ)
MW_RS07375	COG1141	Ferredoxin
MW_RS07420	COG1388	LysM domain
MW_RS07420	COG0860	N-Acetylmuramoyl-L-alanine amidase
MW_RS07470	COG3953	SLT domain
MW_RS07470	COG5280	Phage tail tape measure protein TP901
MW_RS07715	COG0582	viral genome integration into host DNA
MW_RS07735	COG5002	protein histidine kinase activity
MW_RS07740	COG0745	RESPONSE REGULATOR receiver
MW_RS07745	COG1187	pseudouridine synthase activity
MW_RS07770	COG0735	belongs to the Fur family
MW_RS07775	COG0494	nUDIX hydrolase
MW_RS07780	COG0667	Aldo Keto reductase
MW_RS07790	COG4221	oxidoreductase activity
MW_RS07805	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MW_RS07815	COG0366	Alpha amylase catalytic
MW_RS07820	COG1609	Transcriptional regulator
MW_RS07840	COG2195	Cleaves the N-terminal amino acid of tripeptides
MW_RS07850	COG4129	membrane
MW_RS07860	COG0508	dehydrogenase complex catalyzes the overall conversion of
MW_RS07865	COG0022	dehydrogenase e1 component
MW_RS07870	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MW_RS07875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MW_RS07880	COG0497	DNA recombination
MW_RS07910	COG1302	Protein conserved in bacteria
MW_RS07915	COG0439	Biotin carboxylase
MW_RS07920	COG0511	ligase activity, forming carbon-carbon bonds
MW_RS07930	COG0006	proline dipeptidase activity
MW_RS07945	COG0095	Lipoate-protein ligase
MW_RS07950	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MW_RS07995	COG4537	Required for transformation and DNA binding
MW_RS08000	COG1459	type II secretion system
MW_RS08005	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MW_RS08010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MW_RS08015	COG0011	TIGRFAM Protein of
MW_RS08020	COG1940	carbohydrate kinase activity
MW_RS08025	COG4483	Protein conserved in bacteria
MW_RS08035	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MW_RS08045	COG0768	penicillin binding
MW_RS08060	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MW_RS08065	COG1121	(ABC) transporter
MW_RS08075	COG0513	Belongs to the DEAD box helicase family
MW_RS08085	COG2384	SAM-dependent methyltransferase
MW_RS08105	COG0517	IMP dehydrogenase activity
MW_RS08125	COG0295	cytidine deaminase activity
MW_RS08140	COG1702	phosphate starvation-inducible protein PhoH
MW_RS08155	COG1030	water channel activity
MW_RS08165	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MW_RS08170	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MW_RS08200	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MW_RS08215	COG1466	dna polymerase III delta subunit
MW_RS08220	COG0658	competence protein
MW_RS08220	COG2333	competence protein COMEC
MW_RS08225	COG2131	deaminase
MW_RS08230	COG2183	response to ionizing radiation
MW_RS08235	COG2226	methyltransferase
MW_RS08240	COG0799	negative regulation of ribosome biogenesis
MW_RS08245	COG1713	HD superfamily hydrolase involved in NAD metabolism
MW_RS08255	COG1534	Rna-binding protein
MW_RS08265	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MW_RS08270	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
MW_RS08295	COG3177	Filamentation induced by cAMP protein fic
MW_RS08300	COG1914	H( )-stimulated, divalent metal cation uptake system
MW_RS08310	COG0439	Biotin carboxylase
MW_RS08315	COG0511	ligase activity, forming carbon-carbon bonds
MW_RS08320	COG1984	allophanate hydrolase subunit 2
MW_RS08325	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MW_RS08340	COG0826	peptidase U32
MW_RS08345	COG0826	peptidase U32
MW_RS08375	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MW_RS08395	COG1104	cysteine desulfurase activity
MW_RS08400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MW_RS08410	COG3237	CsbD-like
MW_RS08415	COG1959	2 iron, 2 sulfur cluster binding
MW_RS08420	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MW_RS08425	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MW_RS08465	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
MW_RS08465	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MW_RS08470	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MW_RS08470	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MW_RS08475	COG1862	Preprotein translocase
MW_RS08515	COG2868	ribosomal protein
MW_RS08555	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
MW_RS08565	COG0285	dihydrofolate synthase activity
MW_RS08575	COG2818	Glycosylase
MW_RS08610	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MW_RS08645	COG4112	unkown
MW_RS08670	COG0833	amino acid
MW_RS08685	COG1484	DNA-dependent DNA replication
MW_RS08715	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MW_RS08715	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MW_RS08725	COG5002	protein histidine kinase activity
MW_RS08730	COG0745	RESPONSE REGULATOR receiver
MW_RS08745	COG0372	Belongs to the citrate synthase family
MW_RS08750	COG1113	amino acid transport
MW_RS08775	COG0281	malic enzyme
MW_RS08785	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MW_RS08795	COG4109	DRTGG domain
MW_RS08835	COG0827	DNA restriction-modification system
MW_RS08845	COG0730	response to heat
MW_RS08855	COG1104	cysteine desulfurase activity
MW_RS08870	COG1956	GAF domain-containing protein
MW_RS08885	COG0584	glycerophosphoryl diester phosphodiesterase
MW_RS08890	COG1764	response to oxidative stress
MW_RS08895	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MW_RS08900	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MW_RS08915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MW_RS08915	COG1263	PTS System
MW_RS08920	COG0204	Acyl-transferase
MW_RS08925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MW_RS08960	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MW_RS08965	COG0454	-acetyltransferase
MW_RS08985	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MW_RS08985	COG1605	Chorismate mutase
MW_RS09010	COG1674	ftsk spoiiie
MW_RS09015	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MW_RS09025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MW_RS09030	COG1363	Peptidase, m42
MW_RS09040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MW_RS09050	COG0510	thiamine kinase activity
MW_RS09070	COG1187	pseudouridine synthase activity
MW_RS09075	COG2244	polysaccharide biosynthetic process
MW_RS09080	COG2081	HI0933 family
MW_RS09100	COG2814	Major facilitator Superfamily
MW_RS09105	COG1242	4 iron, 4 sulfur cluster binding
MW_RS09110	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MW_RS09120	COG2267	carboxylic ester hydrolase activity
MW_RS09150	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MW_RS09150	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MW_RS09170	COG5632	N-Acetylmuramoyl-L-alanine amidase
MW_RS09170	COG4193	domain, Protein
MW_RS09170	COG3266	domain, Protein
MW_RS09200	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MW_RS09220	COG0656	L-ascorbic acid biosynthetic process
MW_RS09240	COG1506	peptidase
MW_RS09245	COG2816	NAD+ diphosphatase activity
MW_RS09395	COG1131	(ABC) transporter
MW_RS09500	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
MW_RS09530	COG1131	(ABC) transporter
MW_RS09535	COG0537	adenosine 5'-monophosphoramidase activity
MW_RS09565	COG0420	3'-5' exonuclease activity
MW_RS09590	COG2197	response regulator
MW_RS09595	COG2203	Gaf domain
MW_RS09595	COG4585	Histidine kinase
MW_RS09600	COG0564	pseudouridine synthase activity
MW_RS09635	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MW_RS09640	COG1126	abc transporter atp-binding protein
MW_RS09645	COG0765	amino acid transport
MW_RS09810	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MW_RS09815	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MW_RS09825	COG4129	membrane
MW_RS09850	COG1988	membrane-bound metal-dependent
MW_RS09865	COG1388	LysM domain
MW_RS09865	COG1134	teichoic acid transport
MW_RS09895	COG0535	radical SAM domain protein
MW_RS09900	COG1607	acyl-coa hydrolase
MW_RS09905	COG2309	aminopeptidase activity
MW_RS09925	COG1295	ribonuclease BN
MW_RS10050	COG4851	CamS sex pheromone cAM373 precursor
MW_RS10060	COG0210	DNA helicase
MW_RS10070	COG4496	protein, YerC YecD
MW_RS10105	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MW_RS10115	COG0077	Prephenate dehydratase
MW_RS10135	COG1335	isochorismatase
MW_RS10150	COG1012	belongs to the aldehyde dehydrogenase family
MW_RS10200	COG1131	(ABC) transporter
MW_RS10215	COG1725	Transcriptional regulator
MW_RS10270	COG0860	N-Acetylmuramoyl-L-alanine amidase
MW_RS10270	COG1388	LysM domain
MW_RS10285	COG5632	N-Acetylmuramoyl-L-alanine amidase
MW_RS10285	COG1388	LysM domain
MW_RS10335	COG0739	heme binding
MW_RS10390	COG4695	Portal protein
MW_RS10585	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MW_RS10590	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MW_RS10595	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MW_RS10610	COG3728	DNA packaging
MW_RS10610	COG5484	DNA packaging
MW_RS10685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MW_RS10690	COG1621	beta-fructofuranosidase activity
MW_RS10695	COG1609	Transcriptional regulator
MW_RS10700	COG0004	ammonium transporteR
MW_RS10705	COG0425	Belongs to the sulfur carrier protein TusA family
MW_RS10710	COG2391	methyltransferase activity
MW_RS10720	COG0488	(ABC) transporter
MW_RS10730	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MW_RS10740	COG0456	acetyltransferase
MW_RS10745	COG1214	PFAM Peptidase M22, glycoprotease
MW_RS10750	COG0802	atpase or kinase
MW_RS10765	COG0028	Belongs to the TPP enzyme family
MW_RS10835	COG2183	response to ionizing radiation
MW_RS10840	COG1191	sigma factor activity
MW_RS10850	COG1366	Belongs to the anti-sigma-factor antagonist family
MW_RS10855	COG2208	phosphoserine phosphatase activity
MW_RS10890	COG3428	Bacterial PH domain
MW_RS10920	COG2205	protein histidine kinase activity
MW_RS10925	COG0745	RESPONSE REGULATOR receiver
MW_RS10935	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MW_RS10945	COG0772	Belongs to the SEDS family
MW_RS10960	COG1937	Protein conserved in bacteria
MW_RS10970	COG1418	mRNA catabolic process
MW_RS11015	COG0629	single-stranded DNA binding
MW_RS11090	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MW_RS11115	COG0009	L-threonylcarbamoyladenylate synthase
MW_RS11120	COG2890	protein-(glutamine-N5) methyltransferase activity
MW_RS11140	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MW_RS11180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MW_RS11230	COG0813	purine-nucleoside phosphorylase activity
MW_RS11235	COG0783	Belongs to the Dps family
MW_RS11255	COG1482	cell wall glycoprotein biosynthetic process
MW_RS11260	COG0702	epimerase
MW_RS11265	COG0640	Transcriptional regulator
MW_RS11285	COG0561	phosphatase activity
MW_RS11290	COG1119	ATPase activity
MW_RS11305	COG3711	transcriptional antiterminator
MW_RS11335	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MW_RS11395	COG0489	protein tyrosine kinase activity
MW_RS11400	COG2814	Major facilitator Superfamily
MW_RS11415	COG1272	protein, Hemolysin III
MW_RS11425	COG1988	membrane-bound metal-dependent
MW_RS11435	COG3314	Sporulation integral membrane protein YlbJ
MW_RS11440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MW_RS11445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MW_RS11450	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
MW_RS11460	COG3457	Alanine racemase
MW_RS11465	COG4264	IucA IucC family
MW_RS11470	COG2814	Major facilitator Superfamily
MW_RS11495	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MW_RS11505	COG2130	NADP-dependent
MW_RS11575	COG0656	L-ascorbic acid biosynthetic process
MW_RS11580	COG0789	Transcriptional regulator
MW_RS11590	COG5492	domain, Protein
MW_RS11600	COG3527	Alpha-acetolactate decarboxylase
MW_RS11605	COG0028	Belongs to the TPP enzyme family
MW_RS11680	COG0201	protein transport
MW_RS11795	COG2252	PERMEase
MW_RS11840	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MW_RS11905	COG1763	Mo-molybdopterin cofactor biosynthetic process
MW_RS11925	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MW_RS11930	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
MW_RS11935	COG4149	molybdate abc transporter
MW_RS11940	COG0725	ABC transporter, periplasmic molybdate-binding protein
MW_RS11955	COG1268	BioY protein
MW_RS11970	COG1960	acyl-CoA dehydrogenase activity
MW_RS11975	COG4413	Urea transporter
MW_RS12050	COG1757	Na H antiporter
MW_RS12065	COG3942	CHAP domain
MW_RS12140	COG1113	amino acid transport
MW_RS12160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MW_RS12165	COG0385	Bile acid
MW_RS12175	COG1263	PTS System
MW_RS12175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MW_RS12180	COG1737	Transcriptional regulator
MW_RS12200	COG1028	Short-chain dehydrogenase reductase Sdr
MW_RS12205	COG1473	amidohydrolase
MW_RS12220	COG0583	DNA-binding transcription factor activity
MW_RS12240	COG2258	MOSC domain
MW_RS12260	COG1668	transmembrane transport
MW_RS12265	COG4152	abc transporter atp-binding protein
MW_RS12270	COG3152	Membrane
MW_RS12280	COG0786	glutamate:sodium symporter activity
MW_RS12290	COG0598	Magnesium transport protein CorA
MW_RS12305	COG0657	acetylesterase activity
MW_RS12315	COG2814	Major facilitator Superfamily
MW_RS12320	COG1566	PFAM secretion protein HlyD family protein
MW_RS12330	COG2814	Major facilitator Superfamily
MW_RS12395	COG1620	l-lactate permease
MW_RS12415	COG0604	alcohol dehydrogenase
MW_RS12450	COG1511	domain protein
MW_RS12465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MW_RS12465	COG1263	PTS System
MW_RS12480	COG3871	stress protein (general stress protein 26)
MW_RS12520	COG0789	Transcriptional regulator
MW_RS12540	COG2181	nitrate reductase activity
MW_RS12550	COG1140	nitrate reductase beta subunit
MW_RS12555	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
MW_RS12565	COG2146	nitrite reductase [NAD(P)H] activity
MW_RS12570	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MW_RS12580	COG0454	-acetyltransferase
MW_RS12585	COG2116	formate transmembrane transporter activity
MW_RS12600	COG3443	Belongs to the bacterial solute-binding protein 9 family
MW_RS12600	COG0803	Belongs to the bacterial solute-binding protein 9 family
MW_RS12635	COG1126	abc transporter atp-binding protein
MW_RS12640	COG0765	amino acid transport
MW_RS12645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MW_RS12650	COG2814	Major facilitator Superfamily
MW_RS12670	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MW_RS12715	COG0156	8-amino-7-oxononanoate synthase activity
MW_RS12725	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MW_RS12730	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
MW_RS12745	COG1132	(ABC) transporter
MW_RS12750	COG1132	(ABC) transporter
MW_RS12750	COG2375	cellular response to nickel ion
MW_RS12770	COG1929	Belongs to the glycerate kinase type-1 family
MW_RS12780	COG2814	Major facilitator Superfamily
MW_RS12800	COG1113	amino acid transport
MW_RS12815	COG0531	amino acid
MW_RS12840	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MW_RS12850	COG1174	glycine betaine transport
MW_RS12860	COG1174	glycine betaine transport
MW_RS12880	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
MW_RS12885	COG0531	amino acid
MW_RS12890	COG2272	Belongs to the type-B carboxylesterase lipase family
MW_RS12895	COG2814	Major facilitator Superfamily
MW_RS12900	COG0390	transport system, permease component
MW_RS12905	COG4619	ABC transporter
MW_RS12910	COG1363	Peptidase, m42
MW_RS12930	COG4808	Protein conserved in bacteria
MW_RS12935	COG0069	glutamate synthase activity
MW_RS12950	COG1124	(ABC) transporter
MW_RS12955	COG0444	Belongs to the ABC transporter superfamily
MW_RS12960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MW_RS12995	COG1028	Short-chain dehydrogenase reductase Sdr
MW_RS13000	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
MW_RS13005	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MW_RS13080	COG0494	nUDIX hydrolase
MW_RS13120	COG1846	Transcriptional regulator
MW_RS13155	COG1070	Carbohydrate kinase
MW_RS13160	COG1802	Transcriptional regulator
MW_RS13165	COG0789	Transcriptional regulator
MW_RS13170	COG2357	RelA SpoT domain protein
MW_RS13175	COG4876	unkown
MW_RS13185	COG2271	Major facilitator Superfamily
MW_RS13190	COG0586	Pfam SNARE associated Golgi protein
MW_RS13195	COG1131	(ABC) transporter
MW_RS13215	COG3949	Membrane
MW_RS13220	COG0400	carboxylic ester hydrolase activity
MW_RS13225	COG0346	lactoylglutathione lyase activity
MW_RS13230	COG1846	Transcriptional regulator
MW_RS13240	COG2514	catechol 2,3-dioxygenase activity
MW_RS13255	COG0561	phosphatase activity
MW_RS13260	COG1131	(ABC) transporter
MW_RS13270	COG3764	Sortase (surface protein transpeptidase)
MW_RS13290	COG1760	l-serine dehydratase
MW_RS13295	COG1760	l-serine dehydratase
MW_RS13310	COG0697	spore germination
MW_RS13315	COG0657	acetylesterase activity
MW_RS13335	COG0028	Belongs to the TPP enzyme family
MW_RS13350	COG0583	DNA-binding transcription factor activity
MW_RS13360	COG3942	CHAP domain
MW_RS13370	COG3425	synthase
MW_RS13375	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MW_RS13400	COG2409	Drug exporters of the RND superfamily
MW_RS13445	COG0436	Aminotransferase
MW_RS13475	COG3942	CHAP domain
MW_RS13480	COG2755	lipolytic protein G-D-S-L family
MW_RS13480	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MW_RS13590	COG3001	Fructosamine kinase
MW_RS13595	COG0167	dihydroorotate dehydrogenase activity
MW_RS13650	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MW_RS13655	COG3527	Alpha-acetolactate decarboxylase
MW_RS13670	COG0531	amino acid
MW_RS13700	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MW_RS13720	COG1012	belongs to the aldehyde dehydrogenase family
MW_RS13730	COG1510	regulation of RNA biosynthetic process
MW_RS13740	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MW_RS13765	COG2851	Citrate transporter
MW_RS13775	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MW_RS13785	COG0386	Belongs to the glutathione peroxidase family
MW_RS13810	COG1136	(ABC) transporter
MW_RS13815	COG2205	protein histidine kinase activity
MW_RS13820	COG0745	RESPONSE REGULATOR receiver
MW_RS13835	COG1785	Belongs to the alkaline phosphatase family
MW_RS13840	COG1846	Transcriptional regulator
MW_RS13885	COG1438	arginine binding
MW_RS13905	COG3711	transcriptional antiterminator
MW_RS13905	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MW_RS13910	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MW_RS13910	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MW_RS13910	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MW_RS13915	COG1482	cell wall glycoprotein biosynthetic process
MW_RS13925	COG3942	CHAP domain
MW_RS13925	COG1705	Flagellar rod assembly protein muramidase FlgJ
MW_RS13930	COG1535	isochorismatase
MW_RS13930	COG3433	isochorismatase activity
MW_RS13945	COG0438	transferase activity, transferring glycosyl groups
MW_RS13960	COG1073	alpha beta
MW_RS13980	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MW_RS14000	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MW_RS14055	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
MW_RS14090	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MW_RS14175	COG0471	metal ion transport
MW_RS14180	COG2962	Rard protein
MW_RS14190	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
MW_RS14205	COG1136	(ABC) transporter
MW_RS14210	COG0577	efflux transmembrane transporter activity
MW_RS14220	COG1278	Cold shock
MW_RS14240	COG1475	DNA binding