locus-tag	class	description
NMK49_RS00015	COG2501	S4 domain
NMK49_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NMK49_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NMK49_RS00060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NMK49_RS00070	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
NMK49_RS00075	COG0359	binds to the 23S rRNA
NMK49_RS00080	COG0305	Participates in initiation and elongation during chromosome replication
NMK49_RS00110	COG4863	YycH protein
NMK49_RS00120	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
NMK49_RS00125	COG0737	Belongs to the 5'-nucleotidase family
NMK49_RS00160	COG0730	response to heat
NMK49_RS00165	COG1937	Protein conserved in bacteria
NMK49_RS00170	COG2210	Belongs to the sulfur carrier protein TusA family
NMK49_RS00175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NMK49_RS00205	COG0655	NAD(P)H dehydrogenase (quinone) activity
NMK49_RS00220	COG0583	DNA-binding transcription factor activity
NMK49_RS00240	COG0823	Involved in the tonB-independent uptake of proteins
NMK49_RS00270	COG1473	amidohydrolase
NMK49_RS00280	COG1283	sodium-dependent phosphate transmembrane transporter activity
NMK49_RS00285	COG4716	Myosin-crossreactive antigen
NMK49_RS00290	COG0697	spore germination
NMK49_RS00305	COG1620	l-lactate permease
NMK49_RS00310	COG1388	LysM domain
NMK49_RS00320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NMK49_RS00325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NMK49_RS00330	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NMK49_RS00340	COG2423	ornithine cyclodeaminase activity
NMK49_RS00345	COG4264	IucA IucC family
NMK49_RS00350	COG2814	Major facilitator Superfamily
NMK49_RS00355	COG4264	IucA IucC family
NMK49_RS00360	COG4264	IucA IucC family
NMK49_RS00370	COG0019	diaminopimelate decarboxylase activity
NMK49_RS00375	COG1475	DNA binding
NMK49_RS00400	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NMK49_RS00405	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NMK49_RS00410	COG0438	transferase activity, transferring glycosyl groups
NMK49_RS00445	COG0813	purine-nucleoside phosphorylase activity
NMK49_RS00450	COG2814	Major facilitator Superfamily
NMK49_RS00470	COG3639	organic phosphonate transmembrane transporter activity
NMK49_RS00490	COG0737	Belongs to the 5'-nucleotidase family
NMK49_RS00515	COG1454	alcohol dehydrogenase
NMK49_RS00515	COG1012	belongs to the aldehyde dehydrogenase family
NMK49_RS00540	COG1086	Polysaccharide biosynthesis protein
NMK49_RS00550	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NMK49_RS00580	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NMK49_RS00590	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
NMK49_RS00595	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NMK49_RS00605	COG2832	Protein of unknown function (DUF454)
NMK49_RS00640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NMK49_RS00645	COG1960	acyl-CoA dehydrogenase activity
NMK49_RS00650	COG5609	conserved protein (DUF2294)
NMK49_RS00700	COG1114	Component of the transport system for branched-chain amino acids
NMK49_RS00705	COG1335	isochorismatase
NMK49_RS00710	COG3961	Belongs to the TPP enzyme family
NMK49_RS00740	COG1737	Transcriptional regulator
NMK49_RS00775	COG0601	transmembrane transport
NMK49_RS00780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NMK49_RS00790	COG0405	Gamma-glutamyltransferase
NMK49_RS00810	COG3842	ATPase activity
NMK49_RS00820	COG1175	transmembrane transport
NMK49_RS00825	COG3833	ABC-type maltose transport systems, permease component
NMK49_RS00830	COG0673	inositol 2-dehydrogenase activity
NMK49_RS00835	COG0673	inositol 2-dehydrogenase activity
NMK49_RS00845	COG1755	Isoprenylcysteine carboxyl methyltransferase
NMK49_RS00900	COG0183	Belongs to the thiolase family
NMK49_RS00910	COG1960	acyl-CoA dehydrogenase activity
NMK49_RS00915	COG0318	PFAM AMP-dependent synthetase and ligase
NMK49_RS00930	COG0747	negative chemotaxis
NMK49_RS00935	COG3189	MarR family transcriptional regulator
NMK49_RS00960	COG2190	(PTS) system
NMK49_RS00960	COG1263	PTS System
NMK49_RS00960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NMK49_RS00965	COG1957	nucleoside hydrolase
NMK49_RS00985	COG3414	Phosphotransferase system galactitol-specific IIB component
NMK49_RS00990	COG3775	system Galactitol-specific IIC component
NMK49_RS00995	COG1063	alcohol dehydrogenase
NMK49_RS01005	COG1063	alcohol dehydrogenase
NMK49_RS01015	COG1063	alcohol dehydrogenase
NMK49_RS01020	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NMK49_RS01025	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NMK49_RS01035	COG1063	alcohol dehydrogenase
NMK49_RS01040	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NMK49_RS01075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NMK49_RS01080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NMK49_RS01080	COG1263	PTS System
NMK49_RS01080	COG2190	(PTS) system
NMK49_RS01085	COG2723	6-phospho-beta-galactosidase activity
NMK49_RS01090	COG2226	methyltransferase
NMK49_RS01150	COG1131	(ABC) transporter
NMK49_RS01180	COG3942	CHAP domain
NMK49_RS01180	COG1388	LysM domain
NMK49_RS01340	COG1114	Component of the transport system for branched-chain amino acids
NMK49_RS01345	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
NMK49_RS01350	COG0577	efflux transmembrane transporter activity
NMK49_RS01380	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NMK49_RS01385	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NMK49_RS01410	COG3314	Sporulation integral membrane protein YlbJ
NMK49_RS01435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NMK49_RS01460	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NMK49_RS01465	COG3037	sugar-specific permease SgaT UlaA
NMK49_RS01475	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NMK49_RS01480	COG3711	transcriptional antiterminator
NMK49_RS01500	COG2271	Major facilitator Superfamily
NMK49_RS01505	COG0346	lactoylglutathione lyase activity
NMK49_RS01510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NMK49_RS01515	COG0431	NADPH-dependent FMN reductase
NMK49_RS01525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NMK49_RS01530	COG2822	iron ion transport
NMK49_RS01540	COG0672	)-iron permease
NMK49_RS01545	COG0805	protein transport
NMK49_RS01550	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NMK49_RS01560	COG1476	TRANSCRIPTIONal
NMK49_RS01570	COG1131	(ABC) transporter
NMK49_RS01600	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
NMK49_RS01600	COG0646	methionine synthase
NMK49_RS01605	COG0626	cystathionine gamma-synthase activity
NMK49_RS01610	COG0626	cystathionine gamma-synthase activity
NMK49_RS01615	COG1475	DNA binding
NMK49_RS01620	COG0668	transmembrane transport
NMK49_RS01625	COG4481	Protein conserved in bacteria
NMK49_RS01630	COG0012	GTP binding
NMK49_RS01715	COG3634	alkyl hydroperoxide reductase activity
NMK49_RS01730	COG1823	symporter activity
NMK49_RS01760	COG2233	PERMEase
NMK49_RS01795	COG3759	membrane
NMK49_RS01925	COG0523	cobalamin synthesis protein
NMK49_RS01945	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NMK49_RS01955	COG5609	conserved protein (DUF2294)
NMK49_RS01970	COG1647	Serine aminopeptidase, S33
NMK49_RS01980	COG0733	neurotransmitter:sodium symporter activity
NMK49_RS01985	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NMK49_RS01990	COG0626	cystathionine gamma-synthase activity
NMK49_RS02000	COG2011	ABC-type metal ion transport system permease component
NMK49_RS02005	COG1464	Belongs to the NlpA lipoprotein family
NMK49_RS02040	COG0583	DNA-binding transcription factor activity
NMK49_RS02045	COG0070	glutamate synthase
NMK49_RS02045	COG0069	glutamate synthase activity
NMK49_RS02045	COG0067	glutamate synthase
NMK49_RS02050	COG0493	'glutamate synthase
NMK49_RS02060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NMK49_RS02060	COG1263	PTS System
NMK49_RS02065	COG0366	Alpha amylase catalytic
NMK49_RS02070	COG2188	Transcriptional regulator
NMK49_RS02090	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NMK49_RS02125	COG1982	Orn Lys Arg decarboxylase major
NMK49_RS02135	COG3870	Protein conserved in bacteria
NMK49_RS02140	COG0470	DNA polymerase III
NMK49_RS02145	COG1774	PSP1 C-terminal conserved region
NMK49_RS02155	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
NMK49_RS02165	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NMK49_RS02175	COG0084	hydrolase, TatD family'
NMK49_RS02180	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
NMK49_RS02190	COG4466	Protein conserved in bacteria
NMK49_RS02200	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NMK49_RS02205	COG0251	oxidation-reduction process
NMK49_RS02220	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NMK49_RS02245	COG2244	polysaccharide biosynthetic process
NMK49_RS02250	COG3956	TIGRFAM MazG family protein
NMK49_RS02255	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
NMK49_RS02265	COG1098	S1 RNA binding domain
NMK49_RS02280	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NMK49_RS02305	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NMK49_RS02400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NMK49_RS02415	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NMK49_RS02425	COG3880	PFAM UvrB UvrC protein
NMK49_RS02440	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
NMK49_RS02445	COG4956	integral membrane protein (PIN domain superfamily)
NMK49_RS02465	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
NMK49_RS02520	COG2813	Specifically methylates the guanine in position
NMK49_RS02560	COG1473	amidohydrolase
NMK49_RS02590	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NMK49_RS02595	COG1428	Deoxynucleoside kinase
NMK49_RS02600	COG1428	Deoxynucleoside kinase
NMK49_RS02610	COG0561	phosphatase activity
NMK49_RS02625	COG4932	domain protein
NMK49_RS02645	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NMK49_RS02660	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
NMK49_RS02750	COG0095	Lipoate-protein ligase
NMK49_RS02755	COG0083	homoserine kinase activity
NMK49_RS02775	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NMK49_RS02860	COG0667	Aldo Keto reductase
NMK49_RS02865	COG0655	NAD(P)H dehydrogenase (quinone) activity
NMK49_RS02875	COG1078	dGTPase activity
NMK49_RS02910	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NMK49_RS02915	COG4139	cobalamin transport
NMK49_RS02965	COG4974	Belongs to the 'phage' integrase family
NMK49_RS03010	COG0803	Belongs to the bacterial solute-binding protein 9 family
NMK49_RS03015	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NMK49_RS03020	COG1121	(ABC) transporter
NMK49_RS03025	COG1321	iron dependent repressor
NMK49_RS03035	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
NMK49_RS03045	COG1682	transport, permease protein
NMK49_RS03050	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NMK49_RS03055	COG1216	Glycosyl transferase, family 2
NMK49_RS03060	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NMK49_RS03065	COG1686	Belongs to the peptidase S11 family
NMK49_RS03070	COG1132	(ABC) transporter
NMK49_RS03075	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NMK49_RS03085	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NMK49_RS03090	COG1120	ATPase activity
NMK49_RS03095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NMK49_RS03100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NMK49_RS03105	COG2376	Dihydroxyacetone kinase
NMK49_RS03115	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
NMK49_RS03125	COG3949	Membrane
NMK49_RS03145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NMK49_RS03160	COG1136	(ABC) transporter
NMK49_RS03165	COG0577	efflux transmembrane transporter activity
NMK49_RS03170	COG1392	Phosphate transport regulator
NMK49_RS03175	COG0306	phosphate transporter
NMK49_RS03180	COG3942	CHAP domain
NMK49_RS03180	COG1388	LysM domain
NMK49_RS03190	COG4977	sequence-specific DNA binding
NMK49_RS03190	COG1917	Cupin 2, conserved barrel domain protein
NMK49_RS03220	COG0583	DNA-binding transcription factor activity
NMK49_RS03225	COG2814	Major facilitator Superfamily
NMK49_RS03230	COG2839	Protein conserved in bacteria
NMK49_RS03260	COG1611	Belongs to the LOG family
NMK49_RS03280	COG4988	ABC transporter
NMK49_RS03285	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
NMK49_RS03295	COG0523	cobalamin synthesis protein
NMK49_RS03300	COG4989	oxidoreductase activity
NMK49_RS03310	COG0471	metal ion transport
NMK49_RS03315	COG0415	Belongs to the DNA photolyase family
NMK49_RS03345	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NMK49_RS03350	COG1349	DNA-binding transcription factor activity
NMK49_RS03355	COG1105	Belongs to the carbohydrate kinase PfkB family
NMK49_RS03360	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NMK49_RS03360	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NMK49_RS03360	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NMK49_RS03365	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NMK49_RS03370	COG1253	flavin adenine dinucleotide binding
NMK49_RS03375	COG0656	L-ascorbic acid biosynthetic process
NMK49_RS03380	COG0463	Glycosyl transferase, family 2
NMK49_RS03415	COG0720	synthase
NMK49_RS03425	COG0512	Glutamine amidotransferase of anthranilate synthase
NMK49_RS03425	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NMK49_RS03430	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NMK49_RS03460	COG0488	(ABC) transporter
NMK49_RS03465	COG0514	ATP-dependent DNA helicase (RecQ)
NMK49_RS03470	COG1125	glycine betaine transport
NMK49_RS03470	COG0517	IMP dehydrogenase activity
NMK49_RS03475	COG1174	glycine betaine transport
NMK49_RS03500	COG3104	oligopeptide transport
NMK49_RS03525	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NMK49_RS03530	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NMK49_RS03540	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NMK49_RS03545	COG4605	iron ion homeostasis
NMK49_RS03550	COG4604	ABC transporter, ATP-binding protein
NMK49_RS03555	COG4607	ABC-type enterochelin transport system periplasmic component
NMK49_RS03610	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NMK49_RS03615	COG1739	Uncharacterized protein family UPF0029
NMK49_RS03625	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
NMK49_RS03630	COG1040	competence protein
NMK49_RS03660	COG3942	CHAP domain
NMK49_RS03660	COG1388	LysM domain
NMK49_RS03715	COG0391	Required for morphogenesis under gluconeogenic growth conditions
NMK49_RS03755	COG0149	triose-phosphate isomerase activity
NMK49_RS03775	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NMK49_RS03780	COG1647	Serine aminopeptidase, S33
NMK49_RS03785	COG0557	exoribonuclease II activity
NMK49_RS03830	COG3266	domain, Protein
NMK49_RS03830	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
NMK49_RS03855	COG1278	Cold shock
NMK49_RS03895	COG0406	alpha-ribazole phosphatase activity
NMK49_RS03900	COG1279	arginine transmembrane transporter activity
NMK49_RS03925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NMK49_RS03930	COG1393	Belongs to the ArsC family
NMK49_RS03940	COG3878	Protein conserved in bacteria
NMK49_RS03945	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
NMK49_RS03960	COG2011	ABC-type metal ion transport system permease component
NMK49_RS03965	COG1464	Belongs to the NlpA lipoprotein family
NMK49_RS03980	COG0396	ATPase activity
NMK49_RS03985	COG0719	Fe-S assembly protein
NMK49_RS03995	COG0822	iron-sulfur transferase activity
NMK49_RS04015	COG1253	flavin adenine dinucleotide binding
NMK49_RS04030	COG1801	Protein of unknown function DUF72
NMK49_RS04035	COG0730	response to heat
NMK49_RS04050	COG4470	Protein conserved in bacteria
NMK49_RS04060	COG2445	Protein of unknown function DUF86
NMK49_RS04090	COG1696	Membrane protein involved in D-alanine export
NMK49_RS04100	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
NMK49_RS04105	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
NMK49_RS04110	COG4837	Protein of unknown function (DUF1462)
NMK49_RS04115	COG1252	NADH dehydrogenase
NMK49_RS04125	COG0316	Belongs to the HesB IscA family
NMK49_RS04135	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NMK49_RS04140	COG2056	Na+-H+ antiporter family
NMK49_RS04145	COG2050	protein possibly involved in aromatic compounds catabolism
NMK49_RS04200	COG1098	S1 RNA binding domain
NMK49_RS04205	COG1902	pentaerythritol trinitrate reductase activity
NMK49_RS04220	COG0584	glycerophosphoryl diester phosphodiesterase
NMK49_RS04235	COG0166	Belongs to the GPI family
NMK49_RS04240	COG0398	Pfam SNARE associated Golgi protein
NMK49_RS04280	COG0561	phosphatase activity
NMK49_RS04305	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NMK49_RS04320	COG1881	PFAM PEBP family protein
NMK49_RS04350	COG0601	transmembrane transport
NMK49_RS04355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NMK49_RS04360	COG0444	Belongs to the ABC transporter superfamily
NMK49_RS04365	COG4608	Belongs to the ABC transporter superfamily
NMK49_RS04370	COG4166	transmembrane transport
NMK49_RS04375	COG0747	negative chemotaxis
NMK49_RS04380	COG0444	Belongs to the ABC transporter superfamily
NMK49_RS04385	COG4608	Belongs to the ABC transporter superfamily
NMK49_RS04390	COG0601	transmembrane transport
NMK49_RS04395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NMK49_RS04420	COG1164	Oligoendopeptidase f
NMK49_RS04430	COG2346	COG2346, Truncated hemoglobins
NMK49_RS04445	COG2357	RelA SpoT domain protein
NMK49_RS04455	COG0564	pseudouridine synthase activity
NMK49_RS04460	COG2239	Acts as a magnesium transporter
NMK49_RS04465	COG0475	glutathione-regulated potassium exporter activity
NMK49_RS04465	COG0569	domain protein
NMK49_RS04470	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NMK49_RS04475	COG0628	permease
NMK49_RS04480	COG1115	amino acid carrier protein
NMK49_RS04520	COG0861	Integral membrane protein TerC family
NMK49_RS04525	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NMK49_RS04530	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NMK49_RS04535	COG0737	Belongs to the 5'-nucleotidase family
NMK49_RS04550	COG4903	ComK protein
NMK49_RS04565	COG4873	Protein conserved in bacteria
NMK49_RS04625	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
NMK49_RS04635	COG2314	TM2 domain
NMK49_RS04640	COG0456	acetyltransferase
NMK49_RS04645	COG1575	Belongs to the MenA family. Type 1 subfamily
NMK49_RS04655	COG1169	isochorismate synthase
NMK49_RS04665	COG2267	carboxylic ester hydrolase activity
NMK49_RS04690	COG0436	Aminotransferase
NMK49_RS04695	COG3594	Acyltransferase
NMK49_RS04710	COG3266	domain, Protein
NMK49_RS04710	COG4193	domain, Protein
NMK49_RS04710	COG5632	N-Acetylmuramoyl-L-alanine amidase
NMK49_RS04725	COG1316	TRANSCRIPTIONal
NMK49_RS04730	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NMK49_RS04770	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NMK49_RS04785	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NMK49_RS04815	COG0138	bifunctional purine biosynthesis protein purh
NMK49_RS04825	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NMK49_RS04830	COG4172	Belongs to the ABC transporter superfamily
NMK49_RS04835	COG4721	ABC-type cobalt transport system, permease component
NMK49_RS04850	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NMK49_RS04875	COG1271	oxidase subunit
NMK49_RS04880	COG1294	oxidase, subunit
NMK49_RS04885	COG0569	domain protein
NMK49_RS04950	COG1176	ABC-type spermidine putrescine transport system, permease component I
NMK49_RS04955	COG1177	transmembrane transport
NMK49_RS04960	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
NMK49_RS04985	COG0483	inositol monophosphate 1-phosphatase activity
NMK49_RS04995	COG1217	gtp-binding protein TYPA
NMK49_RS05005	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NMK49_RS05015	COG0772	Belongs to the SEDS family
NMK49_RS05045	COG3679	Belongs to the UPF0342 family
NMK49_RS05065	COG0742	ribosomal rna small subunit methyltransferase
NMK49_RS05120	COG4509	Sortase family
NMK49_RS05135	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NMK49_RS05155	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
NMK49_RS05165	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NMK49_RS05165	COG1796	DNA polymerase
NMK49_RS05190	COG2009	succinate dehydrogenase
NMK49_RS05195	COG1053	succinate dehydrogenase
NMK49_RS05200	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NMK49_RS05305	COG1288	antiporter activity
NMK49_RS05340	COG1011	Hydrolase
NMK49_RS05365	COG4839	cell division protein FtsL
NMK49_RS05370	COG0768	penicillin binding
NMK49_RS05385	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NMK49_RS05390	COG0849	cell division
NMK49_RS05405	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NMK49_RS05415	COG0762	integral membrane protein
NMK49_RS05420	COG2302	S4 RNA-binding domain
NMK49_RS05425	COG3599	regulation of cell shape
NMK49_RS05435	COG2514	catechol 2,3-dioxygenase activity
NMK49_RS05450	COG0564	pseudouridine synthase activity
NMK49_RS05460	COG2233	PERMEase
NMK49_RS05505	COG1293	RNA-binding protein homologous to eukaryotic snRNP
NMK49_RS05520	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NMK49_RS05525	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NMK49_RS05535	COG2314	TM2 domain
NMK49_RS05550	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NMK49_RS05550	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NMK49_RS05560	COG0631	protein serine/threonine phosphatase activity
NMK49_RS05575	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NMK49_RS05590	COG1302	Protein conserved in bacteria
NMK49_RS05600	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NMK49_RS05635	COG1196	nuclear chromosome segregation
NMK49_RS05640	COG0552	protein localization to endoplasmic reticulum
NMK49_RS05650	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NMK49_RS05710	COG0758	DNA mediated transformation
NMK49_RS05805	COG0195	Participates in both transcription termination and antitermination
NMK49_RS05810	COG2740	Nucleic-acid-binding protein implicated in transcription termination
NMK49_RS05835	COG0196	riboflavin kinase activity
NMK49_RS05860	COG2188	Transcriptional regulator
NMK49_RS05865	COG0612	Peptidase, M16
NMK49_RS05870	COG0612	Peptidase, M16
NMK49_RS05875	COG0300	oxidoreductase activity
NMK49_RS05895	COG1546	Belongs to the CinA family
NMK49_RS05895	COG1058	Belongs to the CinA family
NMK49_RS05915	COG1692	metallophosphoesterase
NMK49_RS05920	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
NMK49_RS05920	COG0674	pyruvate-flavodoxin oxidoreductase activity
NMK49_RS05925	COG1013	pyruvate-flavodoxin oxidoreductase activity
NMK49_RS05950	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NMK49_RS05960	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
NMK49_RS05965	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NMK49_RS05990	COG1923	regulation of RNA biosynthetic process
NMK49_RS06000	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NMK49_RS06005	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
NMK49_RS06010	COG0789	Transcriptional regulator
NMK49_RS06110	COG1131	(ABC) transporter
NMK49_RS06125	COG2197	response regulator
NMK49_RS06135	COG1525	nuclease
NMK49_RS06150	COG0527	aspartate kinase activity
NMK49_RS06155	COG0460	homoserine dehydrogenase
NMK49_RS06160	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NMK49_RS06185	COG0833	amino acid
NMK49_RS06215	COG2340	Cysteine-rich secretory protein family
NMK49_RS06250	COG4846	Membrane protein involved in cytochrome C biogenesis
NMK49_RS06270	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NMK49_RS06280	COG0824	Thioesterase
NMK49_RS06300	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NMK49_RS06305	COG1115	amino acid carrier protein
NMK49_RS06320	COG0628	permease
NMK49_RS06325	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NMK49_RS06325	COG0392	lysyltransferase activity
NMK49_RS06345	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NMK49_RS06350	COG0287	Prephenate dehydrogenase
NMK49_RS06355	COG1363	Peptidase, m42
NMK49_RS06360	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NMK49_RS06365	COG0512	Glutamine amidotransferase of anthranilate synthase
NMK49_RS06405	COG0561	phosphatase activity
NMK49_RS06450	COG0704	Plays a role in the regulation of phosphate uptake
NMK49_RS06460	COG0581	inorganic phosphate transmembrane transporter activity
NMK49_RS06465	COG0573	inorganic phosphate transmembrane transporter activity
NMK49_RS06485	COG0488	(ABC) transporter
NMK49_RS06490	COG0527	aspartate kinase activity
NMK49_RS06495	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NMK49_RS06570	COG4548	von Willebrand factor, type A
NMK49_RS06575	COG0714	Associated with various cellular activities
NMK49_RS06620	COG0671	phosphoesterase, PA-phosphatase related
NMK49_RS06680	COG1413	lyase activity
NMK49_RS06695	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
NMK49_RS06715	COG0531	amino acid
NMK49_RS06725	COG0686	Belongs to the AlaDH PNT family
NMK49_RS06730	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NMK49_RS06735	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
NMK49_RS06750	COG0116	Belongs to the methyltransferase superfamily
NMK49_RS06785	COG4499	WXG100 protein secretion system (Wss), protein YukC
NMK49_RS06785	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NMK49_RS06795	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NMK49_RS06800	COG3935	DnaD domain protein
NMK49_RS06825	COG0438	transferase activity, transferring glycosyl groups
NMK49_RS06830	COG1694	Mazg nucleotide pyrophosphohydrolase
NMK49_RS06835	COG2738	Putative neutral zinc metallopeptidase
NMK49_RS06840	COG4347	Protein of unknown function (DUF1405)
NMK49_RS06845	COG5582	Belongs to the UPF0302 family
NMK49_RS06860	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NMK49_RS06880	COG0142	geranyltranstransferase activity
NMK49_RS06935	COG0492	ferredoxin-NADP+ reductase activity
NMK49_RS06950	COG0514	ATP-dependent DNA helicase (RecQ)
NMK49_RS06960	COG1141	Ferredoxin
NMK49_RS07005	COG5002	protein histidine kinase activity
NMK49_RS07010	COG0745	RESPONSE REGULATOR receiver
NMK49_RS07015	COG1187	pseudouridine synthase activity
NMK49_RS07040	COG0735	belongs to the Fur family
NMK49_RS07045	COG0494	nUDIX hydrolase
NMK49_RS07050	COG0667	Aldo Keto reductase
NMK49_RS07060	COG4221	oxidoreductase activity
NMK49_RS07075	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NMK49_RS07085	COG0366	Alpha amylase catalytic
NMK49_RS07090	COG1609	Transcriptional regulator
NMK49_RS07110	COG2195	Cleaves the N-terminal amino acid of tripeptides
NMK49_RS07120	COG4129	membrane
NMK49_RS07130	COG0508	dehydrogenase complex catalyzes the overall conversion of
NMK49_RS07135	COG0022	dehydrogenase e1 component
NMK49_RS07140	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NMK49_RS07145	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NMK49_RS07150	COG0497	DNA recombination
NMK49_RS07180	COG1302	Protein conserved in bacteria
NMK49_RS07185	COG0439	Biotin carboxylase
NMK49_RS07190	COG0511	ligase activity, forming carbon-carbon bonds
NMK49_RS07200	COG0006	proline dipeptidase activity
NMK49_RS07215	COG0095	Lipoate-protein ligase
NMK49_RS07220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NMK49_RS07265	COG4537	Required for transformation and DNA binding
NMK49_RS07275	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NMK49_RS07280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NMK49_RS07285	COG0011	TIGRFAM Protein of
NMK49_RS07290	COG1940	carbohydrate kinase activity
NMK49_RS07295	COG4483	Protein conserved in bacteria
NMK49_RS07305	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NMK49_RS07315	COG0768	penicillin binding
NMK49_RS07330	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NMK49_RS07335	COG1121	(ABC) transporter
NMK49_RS07345	COG0513	Belongs to the DEAD box helicase family
NMK49_RS07355	COG2384	SAM-dependent methyltransferase
NMK49_RS07375	COG0517	IMP dehydrogenase activity
NMK49_RS07390	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NMK49_RS07395	COG0295	cytidine deaminase activity
NMK49_RS07410	COG1702	phosphate starvation-inducible protein PhoH
NMK49_RS07425	COG1030	water channel activity
NMK49_RS07435	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NMK49_RS07440	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NMK49_RS07470	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NMK49_RS07485	COG1466	dna polymerase III delta subunit
NMK49_RS07490	COG2333	competence protein COMEC
NMK49_RS07490	COG0658	competence protein
NMK49_RS07495	COG2131	deaminase
NMK49_RS07505	COG2226	methyltransferase
NMK49_RS07510	COG0799	negative regulation of ribosome biogenesis
NMK49_RS07515	COG1713	HD superfamily hydrolase involved in NAD metabolism
NMK49_RS07525	COG1534	Rna-binding protein
NMK49_RS07535	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NMK49_RS07540	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
NMK49_RS07560	COG3177	Filamentation induced by cAMP protein fic
NMK49_RS07565	COG1914	H( )-stimulated, divalent metal cation uptake system
NMK49_RS07575	COG0439	Biotin carboxylase
NMK49_RS07580	COG0511	ligase activity, forming carbon-carbon bonds
NMK49_RS07585	COG1984	allophanate hydrolase subunit 2
NMK49_RS07590	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
NMK49_RS07605	COG0826	peptidase U32
NMK49_RS07610	COG0826	peptidase U32
NMK49_RS07640	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NMK49_RS07655	COG1104	cysteine desulfurase activity
NMK49_RS07660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NMK49_RS07670	COG3237	CsbD-like
NMK49_RS07675	COG1959	2 iron, 2 sulfur cluster binding
NMK49_RS07680	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NMK49_RS07685	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
NMK49_RS07700	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NMK49_RS07730	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
NMK49_RS07730	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NMK49_RS07735	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NMK49_RS07735	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NMK49_RS07740	COG1862	Preprotein translocase
NMK49_RS07780	COG2868	ribosomal protein
NMK49_RS07825	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
NMK49_RS07830	COG0285	dihydrofolate synthase activity
NMK49_RS07840	COG2818	Glycosylase
NMK49_RS07875	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NMK49_RS07880	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NMK49_RS07910	COG4112	unkown
NMK49_RS07930	COG0833	amino acid
NMK49_RS07935	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NMK49_RS07945	COG1484	DNA-dependent DNA replication
NMK49_RS07975	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NMK49_RS07975	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NMK49_RS07985	COG5002	protein histidine kinase activity
NMK49_RS07990	COG0745	RESPONSE REGULATOR receiver
NMK49_RS08000	COG0372	Belongs to the citrate synthase family
NMK49_RS08005	COG1113	amino acid transport
NMK49_RS08035	COG0281	malic enzyme
NMK49_RS08040	COG0587	DNA-directed DNA polymerase activity
NMK49_RS08045	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NMK49_RS08050	COG4109	DRTGG domain
NMK49_RS08090	COG0827	DNA restriction-modification system
NMK49_RS08110	COG1104	cysteine desulfurase activity
NMK49_RS08125	COG1956	GAF domain-containing protein
NMK49_RS08135	COG0584	glycerophosphoryl diester phosphodiesterase
NMK49_RS08140	COG1764	response to oxidative stress
NMK49_RS08145	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NMK49_RS08150	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NMK49_RS08165	COG1263	PTS System
NMK49_RS08165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NMK49_RS08170	COG0204	Acyl-transferase
NMK49_RS08175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NMK49_RS08195	COG5386	Cell surface protein
NMK49_RS08205	COG2759	Belongs to the formate--tetrahydrofolate ligase family
NMK49_RS08210	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NMK49_RS08215	COG0454	-acetyltransferase
NMK49_RS08235	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
NMK49_RS08235	COG1605	Chorismate mutase
NMK49_RS08260	COG1674	ftsk spoiiie
NMK49_RS08265	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NMK49_RS08275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NMK49_RS08280	COG1363	Peptidase, m42
NMK49_RS08290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NMK49_RS08300	COG0510	thiamine kinase activity
NMK49_RS08320	COG1187	pseudouridine synthase activity
NMK49_RS08325	COG2244	polysaccharide biosynthetic process
NMK49_RS08330	COG2081	HI0933 family
NMK49_RS08350	COG2814	Major facilitator Superfamily
NMK49_RS08355	COG1242	4 iron, 4 sulfur cluster binding
NMK49_RS08360	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
NMK49_RS08375	COG2267	carboxylic ester hydrolase activity
NMK49_RS08405	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NMK49_RS08405	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NMK49_RS08430	COG4193	domain, Protein
NMK49_RS08430	COG3266	domain, Protein
NMK49_RS08430	COG5632	N-Acetylmuramoyl-L-alanine amidase
NMK49_RS08440	COG1595	DNA-templated transcription, initiation
NMK49_RS08460	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NMK49_RS08485	COG0656	L-ascorbic acid biosynthetic process
NMK49_RS08510	COG1506	peptidase
NMK49_RS08675	COG1131	(ABC) transporter
NMK49_RS08780	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
NMK49_RS08785	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NMK49_RS08810	COG1131	(ABC) transporter
NMK49_RS08815	COG0537	adenosine 5'-monophosphoramidase activity
NMK49_RS08845	COG0420	3'-5' exonuclease activity
NMK49_RS08870	COG2197	response regulator
NMK49_RS08875	COG4585	Histidine kinase
NMK49_RS08875	COG2203	Gaf domain
NMK49_RS08880	COG0564	pseudouridine synthase activity
NMK49_RS08910	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NMK49_RS08915	COG1126	abc transporter atp-binding protein
NMK49_RS08920	COG0765	amino acid transport
NMK49_RS09095	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NMK49_RS09100	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NMK49_RS09110	COG4129	membrane
NMK49_RS09135	COG1988	membrane-bound metal-dependent
NMK49_RS09145	COG1388	LysM domain
NMK49_RS09145	COG1134	teichoic acid transport
NMK49_RS09175	COG0535	radical SAM domain protein
NMK49_RS09180	COG1607	acyl-coa hydrolase
NMK49_RS09185	COG2309	aminopeptidase activity
NMK49_RS09205	COG1295	ribonuclease BN
NMK49_RS09210	COG2197	response regulator
NMK49_RS09320	COG4851	CamS sex pheromone cAM373 precursor
NMK49_RS09330	COG0210	DNA helicase
NMK49_RS09340	COG4496	protein, YerC YecD
NMK49_RS09375	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
NMK49_RS09385	COG0077	Prephenate dehydratase
NMK49_RS09395	COG0471	metal ion transport
NMK49_RS09405	COG1335	isochorismatase
NMK49_RS09420	COG1012	belongs to the aldehyde dehydrogenase family
NMK49_RS09475	COG1131	(ABC) transporter
NMK49_RS09490	COG1725	Transcriptional regulator
NMK49_RS09535	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
NMK49_RS09540	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NMK49_RS09545	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NMK49_RS09560	COG5484	DNA packaging
NMK49_RS09560	COG3728	DNA packaging
NMK49_RS09635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NMK49_RS09640	COG1621	beta-fructofuranosidase activity
NMK49_RS09645	COG1609	Transcriptional regulator
NMK49_RS09650	COG0004	ammonium transporteR
NMK49_RS09655	COG0425	Belongs to the sulfur carrier protein TusA family
NMK49_RS09660	COG2391	methyltransferase activity
NMK49_RS09670	COG0488	(ABC) transporter
NMK49_RS09680	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NMK49_RS09690	COG0456	acetyltransferase
NMK49_RS09695	COG1214	PFAM Peptidase M22, glycoprotease
NMK49_RS09700	COG0802	atpase or kinase
NMK49_RS09715	COG0028	Belongs to the TPP enzyme family
NMK49_RS09735	COG0473	3-isopropylmalate dehydrogenase activity
NMK49_RS09785	COG2183	response to ionizing radiation
NMK49_RS09790	COG1191	sigma factor activity
NMK49_RS09800	COG1366	Belongs to the anti-sigma-factor antagonist family
NMK49_RS09835	COG3428	Bacterial PH domain
NMK49_RS09865	COG2205	protein histidine kinase activity
NMK49_RS09870	COG0745	RESPONSE REGULATOR receiver
NMK49_RS09880	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NMK49_RS09890	COG0772	Belongs to the SEDS family
NMK49_RS09905	COG1937	Protein conserved in bacteria
NMK49_RS09915	COG1418	mRNA catabolic process
NMK49_RS09940	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NMK49_RS09950	COG0629	single-stranded DNA binding
NMK49_RS10025	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NMK49_RS10050	COG0009	L-threonylcarbamoyladenylate synthase
NMK49_RS10055	COG2890	protein-(glutamine-N5) methyltransferase activity
NMK49_RS10075	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
NMK49_RS10105	COG0504	CTP synthase activity
NMK49_RS10115	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NMK49_RS10160	COG0813	purine-nucleoside phosphorylase activity
NMK49_RS10165	COG0783	Belongs to the Dps family
NMK49_RS10190	COG0702	epimerase
NMK49_RS10195	COG0640	Transcriptional regulator
NMK49_RS10240	COG0561	phosphatase activity
NMK49_RS10245	COG1119	ATPase activity
NMK49_RS10260	COG3711	transcriptional antiterminator
NMK49_RS10270	COG0246	Mannitol dehydrogenase
NMK49_RS10290	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
NMK49_RS10360	COG0489	protein tyrosine kinase activity
NMK49_RS10365	COG2814	Major facilitator Superfamily
NMK49_RS10380	COG1272	protein, Hemolysin III
NMK49_RS10390	COG1988	membrane-bound metal-dependent
NMK49_RS10400	COG3314	Sporulation integral membrane protein YlbJ
NMK49_RS10405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NMK49_RS10410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NMK49_RS10415	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
NMK49_RS10425	COG3457	Alanine racemase
NMK49_RS10430	COG4264	IucA IucC family
NMK49_RS10435	COG2814	Major facilitator Superfamily
NMK49_RS10465	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NMK49_RS10475	COG2130	NADP-dependent
NMK49_RS10525	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NMK49_RS10550	COG0656	L-ascorbic acid biosynthetic process
NMK49_RS10555	COG0789	Transcriptional regulator
NMK49_RS10565	COG5492	domain, Protein
NMK49_RS10585	COG3527	Alpha-acetolactate decarboxylase
NMK49_RS10590	COG0028	Belongs to the TPP enzyme family
NMK49_RS10610	COG0542	response to heat
NMK49_RS10695	COG0201	protein transport
NMK49_RS10810	COG2252	PERMEase
NMK49_RS10815	COG0551	DNA topoisomerase type I activity
NMK49_RS10815	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NMK49_RS10855	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NMK49_RS10915	COG1763	Mo-molybdopterin cofactor biosynthetic process
NMK49_RS10935	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NMK49_RS10940	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
NMK49_RS10945	COG4149	molybdate abc transporter
NMK49_RS10950	COG0725	ABC transporter, periplasmic molybdate-binding protein
NMK49_RS10965	COG1268	BioY protein
NMK49_RS10980	COG1960	acyl-CoA dehydrogenase activity
NMK49_RS10985	COG4413	Urea transporter
NMK49_RS11045	COG3942	CHAP domain
NMK49_RS11055	COG1757	Na H antiporter
NMK49_RS11070	COG3942	CHAP domain
NMK49_RS11140	COG1113	amino acid transport
NMK49_RS11160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NMK49_RS11165	COG0385	Bile acid
NMK49_RS11175	COG1263	PTS System
NMK49_RS11175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NMK49_RS11180	COG1737	Transcriptional regulator
NMK49_RS11200	COG1028	Short-chain dehydrogenase reductase Sdr
NMK49_RS11205	COG1473	amidohydrolase
NMK49_RS11220	COG0583	DNA-binding transcription factor activity
NMK49_RS11245	COG2258	MOSC domain
NMK49_RS11265	COG1668	transmembrane transport
NMK49_RS11270	COG4152	abc transporter atp-binding protein
NMK49_RS11275	COG3152	Membrane
NMK49_RS11285	COG0786	glutamate:sodium symporter activity
NMK49_RS11295	COG0598	Magnesium transport protein CorA
NMK49_RS11310	COG0657	acetylesterase activity
NMK49_RS11320	COG2814	Major facilitator Superfamily
NMK49_RS11325	COG1566	PFAM secretion protein HlyD family protein
NMK49_RS11335	COG2814	Major facilitator Superfamily
NMK49_RS11400	COG1620	l-lactate permease
NMK49_RS11420	COG0604	alcohol dehydrogenase
NMK49_RS11425	COG0456	acetyltransferase
NMK49_RS11445	COG1511	domain protein
NMK49_RS11460	COG1263	PTS System
NMK49_RS11460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NMK49_RS11475	COG3871	stress protein (general stress protein 26)
NMK49_RS11515	COG0789	Transcriptional regulator
NMK49_RS11535	COG2181	nitrate reductase activity
NMK49_RS11545	COG1140	nitrate reductase beta subunit
NMK49_RS11550	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
NMK49_RS11560	COG2146	nitrite reductase [NAD(P)H] activity
NMK49_RS11565	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NMK49_RS11575	COG0454	-acetyltransferase
NMK49_RS11580	COG2116	formate transmembrane transporter activity
NMK49_RS11595	COG3443	Belongs to the bacterial solute-binding protein 9 family
NMK49_RS11595	COG0803	Belongs to the bacterial solute-binding protein 9 family
NMK49_RS11635	COG1126	abc transporter atp-binding protein
NMK49_RS11640	COG0765	amino acid transport
NMK49_RS11645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NMK49_RS11650	COG2814	Major facilitator Superfamily
NMK49_RS11665	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NMK49_RS11705	COG0156	8-amino-7-oxononanoate synthase activity
NMK49_RS11715	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NMK49_RS11720	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
NMK49_RS11730	COG1132	(ABC) transporter
NMK49_RS11735	COG1132	(ABC) transporter
NMK49_RS11735	COG2375	cellular response to nickel ion
NMK49_RS11750	COG1929	Belongs to the glycerate kinase type-1 family
NMK49_RS11760	COG2814	Major facilitator Superfamily
NMK49_RS11780	COG1113	amino acid transport
NMK49_RS11790	COG0531	amino acid
NMK49_RS11795	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NMK49_RS11805	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NMK49_RS11815	COG1174	glycine betaine transport
NMK49_RS11825	COG1174	glycine betaine transport
NMK49_RS11845	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
NMK49_RS11850	COG0531	amino acid
NMK49_RS11855	COG2272	Belongs to the type-B carboxylesterase lipase family
NMK49_RS11860	COG2814	Major facilitator Superfamily
NMK49_RS11865	COG0390	transport system, permease component
NMK49_RS11870	COG4619	ABC transporter
NMK49_RS11875	COG1363	Peptidase, m42
NMK49_RS11890	COG4808	Protein conserved in bacteria
NMK49_RS11895	COG0069	glutamate synthase activity
NMK49_RS11910	COG1124	(ABC) transporter
NMK49_RS11915	COG0444	Belongs to the ABC transporter superfamily
NMK49_RS11920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NMK49_RS11925	COG0601	transmembrane transport
NMK49_RS11930	COG0747	negative chemotaxis
NMK49_RS11960	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
NMK49_RS11965	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NMK49_RS12050	COG0494	nUDIX hydrolase
NMK49_RS12080	COG3583	domain protein
NMK49_RS12085	COG1846	Transcriptional regulator
NMK49_RS12090	COG1846	Transcriptional regulator
NMK49_RS12105	COG4932	domain protein
NMK49_RS12120	COG1070	Carbohydrate kinase
NMK49_RS12125	COG1802	Transcriptional regulator
NMK49_RS12130	COG0789	Transcriptional regulator
NMK49_RS12135	COG2357	RelA SpoT domain protein
NMK49_RS12140	COG4876	unkown
NMK49_RS12150	COG2271	Major facilitator Superfamily
NMK49_RS12155	COG0586	Pfam SNARE associated Golgi protein
NMK49_RS12165	COG2814	Major facilitator Superfamily
NMK49_RS12170	COG1846	Transcriptional regulator
NMK49_RS12175	COG1131	(ABC) transporter
NMK49_RS12190	COG3949	Membrane
NMK49_RS12195	COG0400	carboxylic ester hydrolase activity
NMK49_RS12200	COG0346	lactoylglutathione lyase activity
NMK49_RS12205	COG1846	Transcriptional regulator
NMK49_RS12215	COG2514	catechol 2,3-dioxygenase activity
NMK49_RS12230	COG0561	phosphatase activity
NMK49_RS12235	COG1131	(ABC) transporter
NMK49_RS12245	COG3764	Sortase (surface protein transpeptidase)
NMK49_RS12265	COG1760	l-serine dehydratase
NMK49_RS12270	COG1760	l-serine dehydratase
NMK49_RS12285	COG0697	spore germination
NMK49_RS12290	COG0657	acetylesterase activity
NMK49_RS12310	COG0028	Belongs to the TPP enzyme family
NMK49_RS12325	COG0583	DNA-binding transcription factor activity
NMK49_RS12335	COG3942	CHAP domain
NMK49_RS12360	COG3425	synthase
NMK49_RS12365	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NMK49_RS12370	COG0542	response to heat
NMK49_RS12390	COG2409	Drug exporters of the RND superfamily
NMK49_RS12435	COG0436	Aminotransferase
NMK49_RS12465	COG3942	CHAP domain
NMK49_RS12470	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
NMK49_RS12470	COG2755	lipolytic protein G-D-S-L family
NMK49_RS12495	COG1309	transcriptional regulator
NMK49_RS12540	COG0596	Alpha beta hydrolase
NMK49_RS12575	COG3001	Fructosamine kinase
NMK49_RS12580	COG0167	dihydroorotate dehydrogenase activity
NMK49_RS12620	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NMK49_RS12630	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NMK49_RS12635	COG3527	Alpha-acetolactate decarboxylase
NMK49_RS12645	COG0531	amino acid
NMK49_RS12675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NMK49_RS12695	COG1012	belongs to the aldehyde dehydrogenase family
NMK49_RS12705	COG1510	regulation of RNA biosynthetic process
NMK49_RS12715	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NMK49_RS12740	COG2851	Citrate transporter
NMK49_RS12755	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NMK49_RS12765	COG0386	Belongs to the glutathione peroxidase family
NMK49_RS12785	COG1136	(ABC) transporter
NMK49_RS12790	COG2205	protein histidine kinase activity
NMK49_RS12795	COG0745	RESPONSE REGULATOR receiver
NMK49_RS12805	COG1785	Belongs to the alkaline phosphatase family
NMK49_RS12815	COG1846	Transcriptional regulator
NMK49_RS12860	COG1438	arginine binding
NMK49_RS12880	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NMK49_RS12880	COG3711	transcriptional antiterminator
NMK49_RS12885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NMK49_RS12885	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NMK49_RS12885	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NMK49_RS12890	COG1482	cell wall glycoprotein biosynthetic process
NMK49_RS12900	COG1705	Flagellar rod assembly protein muramidase FlgJ
NMK49_RS12900	COG3942	CHAP domain
NMK49_RS12905	COG1535	isochorismatase
NMK49_RS12905	COG3433	isochorismatase activity
NMK49_RS12920	COG0438	transferase activity, transferring glycosyl groups
NMK49_RS12935	COG1073	alpha beta
NMK49_RS12955	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NMK49_RS12975	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NMK49_RS13030	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
NMK49_RS13060	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NMK49_RS13145	COG0471	metal ion transport
NMK49_RS13150	COG2962	Rard protein
NMK49_RS13160	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
NMK49_RS13175	COG1136	(ABC) transporter
NMK49_RS13180	COG0577	efflux transmembrane transporter activity
NMK49_RS13215	COG1278	Cold shock
NMK49_RS13235	COG1475	DNA binding