locus-tag	class	description
RU53_RS00015	COG2501	S4 domain
RU53_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
RU53_RS00060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RU53_RS00070	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
RU53_RS00080	COG0305	Participates in initiation and elongation during chromosome replication
RU53_RS00110	COG4863	YycH protein
RU53_RS00120	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
RU53_RS00125	COG0737	Belongs to the 5'-nucleotidase family
RU53_RS00150	COG2030	dehydratase
RU53_RS00155	COG0584	glycerophosphoryl diester phosphodiesterase
RU53_RS00200	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
RU53_RS00225	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
RU53_RS00235	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
RU53_RS00250	COG0456	acetyltransferase
RU53_RS00270	COG2189	Belongs to the N(4) N(6)-methyltransferase family
RU53_RS00275	COG3421	Type III restriction
RU53_RS00320	COG0730	response to heat
RU53_RS00325	COG1937	Protein conserved in bacteria
RU53_RS00330	COG2210	Belongs to the sulfur carrier protein TusA family
RU53_RS00335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RU53_RS00385	COG0823	Involved in the tonB-independent uptake of proteins
RU53_RS00430	COG1473	amidohydrolase
RU53_RS00440	COG1283	sodium-dependent phosphate transmembrane transporter activity
RU53_RS00445	COG4716	Myosin-crossreactive antigen
RU53_RS00455	COG1620	l-lactate permease
RU53_RS00470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RU53_RS00475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RU53_RS00480	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RU53_RS00490	COG2423	ornithine cyclodeaminase activity
RU53_RS00495	COG4264	IucA IucC family
RU53_RS00500	COG2814	Major facilitator Superfamily
RU53_RS00505	COG4264	IucA IucC family
RU53_RS00510	COG4264	IucA IucC family
RU53_RS00520	COG0019	diaminopimelate decarboxylase activity
RU53_RS00525	COG1475	DNA binding
RU53_RS00555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RU53_RS00560	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RU53_RS00565	COG0438	transferase activity, transferring glycosyl groups
RU53_RS00600	COG0813	purine-nucleoside phosphorylase activity
RU53_RS00605	COG2814	Major facilitator Superfamily
RU53_RS00625	COG3639	organic phosphonate transmembrane transporter activity
RU53_RS00645	COG0737	Belongs to the 5'-nucleotidase family
RU53_RS00660	COG1012	belongs to the aldehyde dehydrogenase family
RU53_RS00660	COG1454	alcohol dehydrogenase
RU53_RS00685	COG1086	Polysaccharide biosynthesis protein
RU53_RS00695	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
RU53_RS00725	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RU53_RS00735	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
RU53_RS00740	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
RU53_RS00750	COG2832	Protein of unknown function (DUF454)
RU53_RS00785	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RU53_RS00790	COG1960	acyl-CoA dehydrogenase activity
RU53_RS00795	COG5609	conserved protein (DUF2294)
RU53_RS00845	COG1114	Component of the transport system for branched-chain amino acids
RU53_RS00850	COG1335	isochorismatase
RU53_RS00855	COG3961	Belongs to the TPP enzyme family
RU53_RS00885	COG1737	Transcriptional regulator
RU53_RS00920	COG0601	transmembrane transport
RU53_RS00925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RU53_RS00935	COG0405	Gamma-glutamyltransferase
RU53_RS00955	COG3842	ATPase activity
RU53_RS00965	COG1175	transmembrane transport
RU53_RS00970	COG3833	ABC-type maltose transport systems, permease component
RU53_RS00980	COG0673	inositol 2-dehydrogenase activity
RU53_RS00985	COG0673	inositol 2-dehydrogenase activity
RU53_RS00995	COG1755	Isoprenylcysteine carboxyl methyltransferase
RU53_RS01060	COG0183	Belongs to the thiolase family
RU53_RS01070	COG1960	acyl-CoA dehydrogenase activity
RU53_RS01075	COG0318	PFAM AMP-dependent synthetase and ligase
RU53_RS01090	COG0747	negative chemotaxis
RU53_RS01095	COG3189	MarR family transcriptional regulator
RU53_RS01125	COG2190	(PTS) system
RU53_RS01125	COG1263	PTS System
RU53_RS01125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RU53_RS01130	COG1957	nucleoside hydrolase
RU53_RS01150	COG3414	Phosphotransferase system galactitol-specific IIB component
RU53_RS01155	COG3775	system Galactitol-specific IIC component
RU53_RS01160	COG1063	alcohol dehydrogenase
RU53_RS01170	COG1063	alcohol dehydrogenase
RU53_RS01180	COG1063	alcohol dehydrogenase
RU53_RS01185	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
RU53_RS01190	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
RU53_RS01200	COG1063	alcohol dehydrogenase
RU53_RS01205	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
RU53_RS01245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RU53_RS01250	COG1263	PTS System
RU53_RS01250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RU53_RS01250	COG2190	(PTS) system
RU53_RS01255	COG2723	6-phospho-beta-galactosidase activity
RU53_RS01265	COG2226	methyltransferase
RU53_RS01320	COG1131	(ABC) transporter
RU53_RS01340	COG1388	LysM domain
RU53_RS01340	COG3942	CHAP domain
RU53_RS01455	COG1114	Component of the transport system for branched-chain amino acids
RU53_RS01460	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
RU53_RS01470	COG0577	efflux transmembrane transporter activity
RU53_RS01495	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
RU53_RS01500	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RU53_RS01525	COG3314	Sporulation integral membrane protein YlbJ
RU53_RS01550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RU53_RS01580	COG3037	sugar-specific permease SgaT UlaA
RU53_RS01590	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RU53_RS01595	COG3711	transcriptional antiterminator
RU53_RS01615	COG2271	Major facilitator Superfamily
RU53_RS01620	COG0346	lactoylglutathione lyase activity
RU53_RS01625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RU53_RS01630	COG0431	NADPH-dependent FMN reductase
RU53_RS01645	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RU53_RS01650	COG2822	iron ion transport
RU53_RS01660	COG0672	)-iron permease
RU53_RS01665	COG0805	protein transport
RU53_RS01670	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RU53_RS01680	COG1476	TRANSCRIPTIONal
RU53_RS01690	COG1131	(ABC) transporter
RU53_RS01725	COG0646	methionine synthase
RU53_RS01725	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
RU53_RS01730	COG0626	cystathionine gamma-synthase activity
RU53_RS01735	COG0626	cystathionine gamma-synthase activity
RU53_RS01740	COG1475	DNA binding
RU53_RS01745	COG0668	transmembrane transport
RU53_RS01750	COG4481	Protein conserved in bacteria
RU53_RS01755	COG0012	GTP binding
RU53_RS01785	COG4974	Belongs to the 'phage' integrase family
RU53_RS01860	COG1823	symporter activity
RU53_RS01890	COG2233	PERMEase
RU53_RS01965	COG3759	membrane
RU53_RS02155	COG0523	cobalamin synthesis protein
RU53_RS02165	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RU53_RS02175	COG5609	conserved protein (DUF2294)
RU53_RS02190	COG1647	Serine aminopeptidase, S33
RU53_RS02200	COG0733	neurotransmitter:sodium symporter activity
RU53_RS02205	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RU53_RS02210	COG0626	cystathionine gamma-synthase activity
RU53_RS02220	COG2011	ABC-type metal ion transport system permease component
RU53_RS02225	COG1464	Belongs to the NlpA lipoprotein family
RU53_RS02260	COG0583	DNA-binding transcription factor activity
RU53_RS02265	COG0070	glutamate synthase
RU53_RS02265	COG0069	glutamate synthase activity
RU53_RS02265	COG0067	glutamate synthase
RU53_RS02270	COG0493	'glutamate synthase
RU53_RS02285	COG1263	PTS System
RU53_RS02285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RU53_RS02290	COG0366	Alpha amylase catalytic
RU53_RS02295	COG2188	Transcriptional regulator
RU53_RS02310	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RU53_RS02345	COG1982	Orn Lys Arg decarboxylase major
RU53_RS02355	COG3870	Protein conserved in bacteria
RU53_RS02365	COG0470	DNA polymerase III
RU53_RS02370	COG1774	PSP1 C-terminal conserved region
RU53_RS02380	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
RU53_RS02390	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
RU53_RS02405	COG0084	hydrolase, TatD family'
RU53_RS02410	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
RU53_RS02420	COG4466	Protein conserved in bacteria
RU53_RS02430	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RU53_RS02435	COG0251	oxidation-reduction process
RU53_RS02475	COG2244	polysaccharide biosynthetic process
RU53_RS02480	COG3956	TIGRFAM MazG family protein
RU53_RS02485	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
RU53_RS02495	COG1098	S1 RNA binding domain
RU53_RS02510	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RU53_RS02535	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
RU53_RS02630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RU53_RS02645	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
RU53_RS02655	COG3880	PFAM UvrB UvrC protein
RU53_RS02675	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
RU53_RS02680	COG4956	integral membrane protein (PIN domain superfamily)
RU53_RS02700	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
RU53_RS02750	COG2813	Specifically methylates the guanine in position
RU53_RS02790	COG1473	amidohydrolase
RU53_RS02820	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
RU53_RS02825	COG1428	Deoxynucleoside kinase
RU53_RS02830	COG1428	Deoxynucleoside kinase
RU53_RS02840	COG0561	phosphatase activity
RU53_RS02880	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
RU53_RS02895	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
RU53_RS02985	COG0095	Lipoate-protein ligase
RU53_RS02990	COG0083	homoserine kinase activity
RU53_RS03010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RU53_RS03095	COG1484	DNA-dependent DNA replication
RU53_RS03200	COG1783	phage Terminase large subunit
RU53_RS03325	COG5632	N-Acetylmuramoyl-L-alanine amidase
RU53_RS03325	COG1388	LysM domain
RU53_RS03345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RU53_RS03405	COG0667	Aldo Keto reductase
RU53_RS03410	COG0655	NAD(P)H dehydrogenase (quinone) activity
RU53_RS03420	COG1078	dGTPase activity
RU53_RS03455	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RU53_RS03460	COG4139	cobalamin transport
RU53_RS03510	COG4974	Belongs to the 'phage' integrase family
RU53_RS03555	COG0803	Belongs to the bacterial solute-binding protein 9 family
RU53_RS03560	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RU53_RS03565	COG1121	(ABC) transporter
RU53_RS03570	COG1321	iron dependent repressor
RU53_RS03580	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
RU53_RS03590	COG1682	transport, permease protein
RU53_RS03595	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
RU53_RS03605	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
RU53_RS03610	COG1686	Belongs to the peptidase S11 family
RU53_RS03615	COG1132	(ABC) transporter
RU53_RS03620	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
RU53_RS03630	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
RU53_RS03635	COG1120	ATPase activity
RU53_RS03640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RU53_RS03645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RU53_RS03650	COG2376	Dihydroxyacetone kinase
RU53_RS03660	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
RU53_RS03670	COG3949	Membrane
RU53_RS03695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RU53_RS03710	COG1136	(ABC) transporter
RU53_RS03715	COG0577	efflux transmembrane transporter activity
RU53_RS03720	COG1392	Phosphate transport regulator
RU53_RS03725	COG0306	phosphate transporter
RU53_RS03730	COG1388	LysM domain
RU53_RS03730	COG3942	CHAP domain
RU53_RS03740	COG4977	sequence-specific DNA binding
RU53_RS03740	COG1917	Cupin 2, conserved barrel domain protein
RU53_RS03770	COG0583	DNA-binding transcription factor activity
RU53_RS03785	COG2814	Major facilitator Superfamily
RU53_RS03790	COG2839	Protein conserved in bacteria
RU53_RS03820	COG1611	Belongs to the LOG family
RU53_RS03840	COG4988	ABC transporter
RU53_RS03845	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
RU53_RS03855	COG0523	cobalamin synthesis protein
RU53_RS03860	COG4989	oxidoreductase activity
RU53_RS03870	COG0471	metal ion transport
RU53_RS03875	COG0415	Belongs to the DNA photolyase family
RU53_RS03905	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RU53_RS03910	COG1349	DNA-binding transcription factor activity
RU53_RS03915	COG1105	Belongs to the carbohydrate kinase PfkB family
RU53_RS03920	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RU53_RS03920	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RU53_RS03920	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RU53_RS03930	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
RU53_RS03935	COG1253	flavin adenine dinucleotide binding
RU53_RS03940	COG0656	L-ascorbic acid biosynthetic process
RU53_RS03945	COG0463	Glycosyl transferase, family 2
RU53_RS03980	COG0720	synthase
RU53_RS03990	COG0512	Glutamine amidotransferase of anthranilate synthase
RU53_RS03990	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RU53_RS03995	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RU53_RS04030	COG0488	(ABC) transporter
RU53_RS04035	COG0514	ATP-dependent DNA helicase (RecQ)
RU53_RS04040	COG1125	glycine betaine transport
RU53_RS04040	COG0517	IMP dehydrogenase activity
RU53_RS04045	COG1174	glycine betaine transport
RU53_RS04075	COG3104	oligopeptide transport
RU53_RS04095	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RU53_RS04100	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RU53_RS04110	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RU53_RS04115	COG4605	iron ion homeostasis
RU53_RS04120	COG4604	ABC transporter, ATP-binding protein
RU53_RS04125	COG4607	ABC-type enterochelin transport system periplasmic component
RU53_RS04180	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RU53_RS04185	COG1739	Uncharacterized protein family UPF0029
RU53_RS04195	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
RU53_RS04200	COG1040	competence protein
RU53_RS04230	COG1388	LysM domain
RU53_RS04230	COG3942	CHAP domain
RU53_RS04290	COG0391	Required for morphogenesis under gluconeogenic growth conditions
RU53_RS04355	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RU53_RS04360	COG1647	Serine aminopeptidase, S33
RU53_RS04365	COG0557	exoribonuclease II activity
RU53_RS04455	COG3728	DNA packaging
RU53_RS04455	COG5484	DNA packaging
RU53_RS04545	COG1278	Cold shock
RU53_RS04585	COG0406	alpha-ribazole phosphatase activity
RU53_RS04590	COG1279	arginine transmembrane transporter activity
RU53_RS04615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RU53_RS04620	COG1393	Belongs to the ArsC family
RU53_RS04635	COG3878	Protein conserved in bacteria
RU53_RS04645	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
RU53_RS04660	COG2011	ABC-type metal ion transport system permease component
RU53_RS04665	COG1464	Belongs to the NlpA lipoprotein family
RU53_RS04680	COG0396	ATPase activity
RU53_RS04685	COG0719	Fe-S assembly protein
RU53_RS04695	COG0822	iron-sulfur transferase activity
RU53_RS04715	COG1253	flavin adenine dinucleotide binding
RU53_RS04725	COG1801	Protein of unknown function DUF72
RU53_RS04730	COG0730	response to heat
RU53_RS04745	COG4470	Protein conserved in bacteria
RU53_RS04755	COG2445	Protein of unknown function DUF86
RU53_RS04785	COG1696	Membrane protein involved in D-alanine export
RU53_RS04795	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
RU53_RS04800	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
RU53_RS04805	COG4837	Protein of unknown function (DUF1462)
RU53_RS04810	COG1252	NADH dehydrogenase
RU53_RS04820	COG0316	Belongs to the HesB IscA family
RU53_RS04830	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RU53_RS04835	COG2056	Na+-H+ antiporter family
RU53_RS04840	COG2050	protein possibly involved in aromatic compounds catabolism
RU53_RS04895	COG1098	S1 RNA binding domain
RU53_RS04900	COG1902	pentaerythritol trinitrate reductase activity
RU53_RS04920	COG0584	glycerophosphoryl diester phosphodiesterase
RU53_RS04940	COG0398	Pfam SNARE associated Golgi protein
RU53_RS04980	COG0561	phosphatase activity
RU53_RS05020	COG1881	PFAM PEBP family protein
RU53_RS05050	COG0601	transmembrane transport
RU53_RS05055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RU53_RS05060	COG0444	Belongs to the ABC transporter superfamily
RU53_RS05065	COG4608	Belongs to the ABC transporter superfamily
RU53_RS05070	COG4166	transmembrane transport
RU53_RS05075	COG0747	negative chemotaxis
RU53_RS05080	COG0444	Belongs to the ABC transporter superfamily
RU53_RS05085	COG4608	Belongs to the ABC transporter superfamily
RU53_RS05090	COG0601	transmembrane transport
RU53_RS05095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RU53_RS05120	COG1164	Oligoendopeptidase f
RU53_RS05130	COG2346	COG2346, Truncated hemoglobins
RU53_RS05145	COG2357	RelA SpoT domain protein
RU53_RS05155	COG0564	pseudouridine synthase activity
RU53_RS05160	COG2239	Acts as a magnesium transporter
RU53_RS05165	COG0475	glutathione-regulated potassium exporter activity
RU53_RS05165	COG0569	domain protein
RU53_RS05175	COG0628	permease
RU53_RS05180	COG1115	amino acid carrier protein
RU53_RS05220	COG0861	Integral membrane protein TerC family
RU53_RS05230	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RU53_RS05235	COG0737	Belongs to the 5'-nucleotidase family
RU53_RS05250	COG4903	ComK protein
RU53_RS05310	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
RU53_RS05320	COG2314	TM2 domain
RU53_RS05325	COG0456	acetyltransferase
RU53_RS05330	COG1575	Belongs to the MenA family. Type 1 subfamily
RU53_RS05335	COG1169	isochorismate synthase
RU53_RS05345	COG2267	carboxylic ester hydrolase activity
RU53_RS05370	COG0436	Aminotransferase
RU53_RS05375	COG3594	Acyltransferase
RU53_RS05405	COG1316	TRANSCRIPTIONal
RU53_RS05450	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
RU53_RS05465	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RU53_RS05505	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
RU53_RS05510	COG4172	Belongs to the ABC transporter superfamily
RU53_RS05515	COG4721	ABC-type cobalt transport system, permease component
RU53_RS05535	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
RU53_RS05555	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RU53_RS05560	COG1271	oxidase subunit
RU53_RS05565	COG1294	oxidase, subunit
RU53_RS05570	COG0569	domain protein
RU53_RS05635	COG1176	ABC-type spermidine putrescine transport system, permease component I
RU53_RS05640	COG1177	transmembrane transport
RU53_RS05645	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
RU53_RS05670	COG0483	inositol monophosphate 1-phosphatase activity
RU53_RS05680	COG1217	gtp-binding protein TYPA
RU53_RS05690	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RU53_RS05700	COG0772	Belongs to the SEDS family
RU53_RS05735	COG3679	Belongs to the UPF0342 family
RU53_RS05755	COG0742	ribosomal rna small subunit methyltransferase
RU53_RS05815	COG4509	Sortase family
RU53_RS05830	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RU53_RS05860	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
RU53_RS05860	COG1796	DNA polymerase
RU53_RS05885	COG2009	succinate dehydrogenase
RU53_RS05890	COG1053	succinate dehydrogenase
RU53_RS05895	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RU53_RS06015	COG1288	antiporter activity
RU53_RS06050	COG1011	Hydrolase
RU53_RS06075	COG4839	cell division protein FtsL
RU53_RS06080	COG0768	penicillin binding
RU53_RS06095	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
RU53_RS06100	COG0849	cell division
RU53_RS06115	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
RU53_RS06125	COG0762	integral membrane protein
RU53_RS06130	COG2302	S4 RNA-binding domain
RU53_RS06135	COG3599	regulation of cell shape
RU53_RS06145	COG2514	catechol 2,3-dioxygenase activity
RU53_RS06160	COG0564	pseudouridine synthase activity
RU53_RS06170	COG2233	PERMEase
RU53_RS06215	COG1293	RNA-binding protein homologous to eukaryotic snRNP
RU53_RS06230	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
RU53_RS06235	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
RU53_RS06260	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RU53_RS06260	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RU53_RS06270	COG0631	protein serine/threonine phosphatase activity
RU53_RS06285	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RU53_RS06300	COG1302	Protein conserved in bacteria
RU53_RS06350	COG1196	nuclear chromosome segregation
RU53_RS06355	COG0552	protein localization to endoplasmic reticulum
RU53_RS06365	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
RU53_RS06425	COG0758	DNA mediated transformation
RU53_RS06520	COG0195	Participates in both transcription termination and antitermination
RU53_RS06525	COG2740	Nucleic-acid-binding protein implicated in transcription termination
RU53_RS06550	COG0196	riboflavin kinase activity
RU53_RS06575	COG2188	Transcriptional regulator
RU53_RS06580	COG0612	Peptidase, M16
RU53_RS06585	COG0612	Peptidase, M16
RU53_RS06590	COG0300	oxidoreductase activity
RU53_RS06610	COG1546	Belongs to the CinA family
RU53_RS06610	COG1058	Belongs to the CinA family
RU53_RS06630	COG1692	metallophosphoesterase
RU53_RS06635	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
RU53_RS06635	COG0674	pyruvate-flavodoxin oxidoreductase activity
RU53_RS06640	COG1013	pyruvate-flavodoxin oxidoreductase activity
RU53_RS06675	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
RU53_RS06680	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RU53_RS06705	COG1923	regulation of RNA biosynthetic process
RU53_RS06715	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RU53_RS06720	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
RU53_RS06725	COG0789	Transcriptional regulator
RU53_RS06820	COG1131	(ABC) transporter
RU53_RS06835	COG2197	response regulator
RU53_RS06845	COG1525	nuclease
RU53_RS06860	COG0527	aspartate kinase activity
RU53_RS06865	COG0460	homoserine dehydrogenase
RU53_RS06870	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
RU53_RS06895	COG0833	amino acid
RU53_RS06925	COG2340	Cysteine-rich secretory protein family
RU53_RS06960	COG4846	Membrane protein involved in cytochrome C biogenesis
RU53_RS06980	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RU53_RS06990	COG0824	Thioesterase
RU53_RS07020	COG1115	amino acid carrier protein
RU53_RS07035	COG0628	permease
RU53_RS07060	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RU53_RS07070	COG1363	Peptidase, m42
RU53_RS07075	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RU53_RS07080	COG0512	Glutamine amidotransferase of anthranilate synthase
RU53_RS07185	COG1968	undecaprenyl-diphosphatase activity
RU53_RS07200	COG2205	protein histidine kinase activity
RU53_RS07225	COG3173	Aminoglycoside phosphotransferase
RU53_RS07245	COG3682	Transcriptional regulator
RU53_RS07270	COG0704	Plays a role in the regulation of phosphate uptake
RU53_RS07280	COG0581	inorganic phosphate transmembrane transporter activity
RU53_RS07285	COG0573	inorganic phosphate transmembrane transporter activity
RU53_RS07310	COG0488	(ABC) transporter
RU53_RS07315	COG0527	aspartate kinase activity
RU53_RS07320	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RU53_RS07395	COG4548	von Willebrand factor, type A
RU53_RS07400	COG0714	Associated with various cellular activities
RU53_RS07445	COG0671	phosphoesterase, PA-phosphatase related
RU53_RS07530	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
RU53_RS07560	COG0531	amino acid
RU53_RS07575	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RU53_RS07580	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
RU53_RS07600	COG0116	Belongs to the methyltransferase superfamily
RU53_RS07630	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RU53_RS07630	COG4499	WXG100 protein secretion system (Wss), protein YukC
RU53_RS07640	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
RU53_RS07645	COG3935	DnaD domain protein
RU53_RS07670	COG0438	transferase activity, transferring glycosyl groups
RU53_RS07675	COG1694	Mazg nucleotide pyrophosphohydrolase
RU53_RS07680	COG2738	Putative neutral zinc metallopeptidase
RU53_RS07685	COG4347	Protein of unknown function (DUF1405)
RU53_RS07725	COG0142	geranyltranstransferase activity
RU53_RS07780	COG0492	ferredoxin-NADP+ reductase activity
RU53_RS07795	COG0514	ATP-dependent DNA helicase (RecQ)
RU53_RS07805	COG1141	Ferredoxin
RU53_RS07850	COG0860	N-Acetylmuramoyl-L-alanine amidase
RU53_RS07850	COG1388	LysM domain
RU53_RS07950	COG0740	serine-type endopeptidase activity
RU53_RS08060	COG1484	DNA-dependent DNA replication
RU53_RS08130	COG3645	SOS response
RU53_RS08130	COG3646	Phage regulatory protein
RU53_RS08140	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RU53_RS08165	COG0582	viral genome integration into host DNA
RU53_RS08180	COG5002	protein histidine kinase activity
RU53_RS08185	COG0745	RESPONSE REGULATOR receiver
RU53_RS08190	COG1187	pseudouridine synthase activity
RU53_RS08215	COG0735	belongs to the Fur family
RU53_RS08220	COG0494	nUDIX hydrolase
RU53_RS08225	COG0667	Aldo Keto reductase
RU53_RS08235	COG4221	oxidoreductase activity
RU53_RS08250	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
RU53_RS08260	COG0366	Alpha amylase catalytic
RU53_RS08265	COG1609	Transcriptional regulator
RU53_RS08295	COG2195	Cleaves the N-terminal amino acid of tripeptides
RU53_RS08305	COG4129	membrane
RU53_RS08315	COG0508	dehydrogenase complex catalyzes the overall conversion of
RU53_RS08320	COG0022	dehydrogenase e1 component
RU53_RS08325	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
RU53_RS08330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RU53_RS08335	COG0497	DNA recombination
RU53_RS08365	COG1302	Protein conserved in bacteria
RU53_RS08370	COG0439	Biotin carboxylase
RU53_RS08375	COG0511	ligase activity, forming carbon-carbon bonds
RU53_RS08385	COG0006	proline dipeptidase activity
RU53_RS08400	COG0095	Lipoate-protein ligase
RU53_RS08405	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RU53_RS08450	COG4537	Required for transformation and DNA binding
RU53_RS08455	COG1459	type II secretion system
RU53_RS08460	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RU53_RS08465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RU53_RS08470	COG0011	TIGRFAM Protein of
RU53_RS08475	COG1940	carbohydrate kinase activity
RU53_RS08480	COG4483	Protein conserved in bacteria
RU53_RS08490	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
RU53_RS08500	COG0768	penicillin binding
RU53_RS08515	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RU53_RS08520	COG1121	(ABC) transporter
RU53_RS08530	COG0513	Belongs to the DEAD box helicase family
RU53_RS08540	COG2384	SAM-dependent methyltransferase
RU53_RS08560	COG0517	IMP dehydrogenase activity
RU53_RS08580	COG0295	cytidine deaminase activity
RU53_RS08595	COG1702	phosphate starvation-inducible protein PhoH
RU53_RS08610	COG1030	water channel activity
RU53_RS08620	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RU53_RS08625	COG1385	rRNA (uridine-N3-)-methyltransferase activity
RU53_RS08655	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RU53_RS08670	COG1466	dna polymerase III delta subunit
RU53_RS08675	COG0658	competence protein
RU53_RS08675	COG2333	competence protein COMEC
RU53_RS08680	COG2131	deaminase
RU53_RS08690	COG2226	methyltransferase
RU53_RS08695	COG0799	negative regulation of ribosome biogenesis
RU53_RS08700	COG1713	HD superfamily hydrolase involved in NAD metabolism
RU53_RS08710	COG1534	Rna-binding protein
RU53_RS08720	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
RU53_RS08725	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
RU53_RS08750	COG3177	Filamentation induced by cAMP protein fic
RU53_RS08755	COG1914	H( )-stimulated, divalent metal cation uptake system
RU53_RS08765	COG0439	Biotin carboxylase
RU53_RS08770	COG0511	ligase activity, forming carbon-carbon bonds
RU53_RS08775	COG1984	allophanate hydrolase subunit 2
RU53_RS08780	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
RU53_RS08795	COG0826	peptidase U32
RU53_RS08800	COG0826	peptidase U32
RU53_RS08830	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RU53_RS08850	COG1104	cysteine desulfurase activity
RU53_RS08855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RU53_RS08865	COG3237	CsbD-like
RU53_RS08870	COG1959	2 iron, 2 sulfur cluster binding
RU53_RS08875	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
RU53_RS08880	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
RU53_RS08920	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
RU53_RS08920	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
RU53_RS08925	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RU53_RS08925	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RU53_RS08930	COG1862	Preprotein translocase
RU53_RS08970	COG2868	ribosomal protein
RU53_RS09010	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
RU53_RS09020	COG0285	dihydrofolate synthase activity
RU53_RS09030	COG2818	Glycosylase
RU53_RS09065	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RU53_RS09100	COG4112	unkown
RU53_RS09125	COG0833	amino acid
RU53_RS09140	COG1484	DNA-dependent DNA replication
RU53_RS09170	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RU53_RS09170	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RU53_RS09180	COG5002	protein histidine kinase activity
RU53_RS09185	COG0745	RESPONSE REGULATOR receiver
RU53_RS09200	COG0372	Belongs to the citrate synthase family
RU53_RS09205	COG1113	amino acid transport
RU53_RS09235	COG0281	malic enzyme
RU53_RS09245	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
RU53_RS09250	COG4109	DRTGG domain
RU53_RS09290	COG0827	DNA restriction-modification system
RU53_RS09300	COG0730	response to heat
RU53_RS09310	COG1104	cysteine desulfurase activity
RU53_RS09325	COG1956	GAF domain-containing protein
RU53_RS09340	COG0584	glycerophosphoryl diester phosphodiesterase
RU53_RS09345	COG1764	response to oxidative stress
RU53_RS09350	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
RU53_RS09355	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RU53_RS09380	COG1263	PTS System
RU53_RS09380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RU53_RS09385	COG0204	Acyl-transferase
RU53_RS09390	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RU53_RS09420	COG2759	Belongs to the formate--tetrahydrofolate ligase family
RU53_RS09425	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RU53_RS09430	COG0454	-acetyltransferase
RU53_RS09450	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
RU53_RS09450	COG1605	Chorismate mutase
RU53_RS09480	COG1674	ftsk spoiiie
RU53_RS09485	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RU53_RS09495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RU53_RS09500	COG1363	Peptidase, m42
RU53_RS09510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RU53_RS09520	COG0510	thiamine kinase activity
RU53_RS09540	COG1187	pseudouridine synthase activity
RU53_RS09545	COG2244	polysaccharide biosynthetic process
RU53_RS09550	COG2081	HI0933 family
RU53_RS09570	COG2814	Major facilitator Superfamily
RU53_RS09575	COG1242	4 iron, 4 sulfur cluster binding
RU53_RS09580	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
RU53_RS09600	COG2267	carboxylic ester hydrolase activity
RU53_RS09630	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RU53_RS09630	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RU53_RS09660	COG4193	domain, Protein
RU53_RS09660	COG5632	N-Acetylmuramoyl-L-alanine amidase
RU53_RS09660	COG3266	domain, Protein
RU53_RS09690	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RU53_RS09710	COG0656	L-ascorbic acid biosynthetic process
RU53_RS09730	COG1506	peptidase
RU53_RS09945	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
RU53_RS09975	COG1131	(ABC) transporter
RU53_RS09980	COG0537	adenosine 5'-monophosphoramidase activity
RU53_RS10010	COG0420	3'-5' exonuclease activity
RU53_RS10035	COG2197	response regulator
RU53_RS10040	COG2203	Gaf domain
RU53_RS10040	COG4585	Histidine kinase
RU53_RS10045	COG0564	pseudouridine synthase activity
RU53_RS10085	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
RU53_RS10090	COG1126	abc transporter atp-binding protein
RU53_RS10095	COG0765	amino acid transport
RU53_RS10260	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RU53_RS10265	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RU53_RS10275	COG4129	membrane
RU53_RS10300	COG1988	membrane-bound metal-dependent
RU53_RS10315	COG1134	teichoic acid transport
RU53_RS10315	COG1388	LysM domain
RU53_RS10345	COG0535	radical SAM domain protein
RU53_RS10350	COG1607	acyl-coa hydrolase
RU53_RS10355	COG2309	aminopeptidase activity
RU53_RS10375	COG1295	ribonuclease BN
RU53_RS10380	COG2197	response regulator
RU53_RS10495	COG4851	CamS sex pheromone cAM373 precursor
RU53_RS10505	COG0210	DNA helicase
RU53_RS10515	COG4496	protein, YerC YecD
RU53_RS10550	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
RU53_RS10560	COG0077	Prephenate dehydratase
RU53_RS10570	COG0471	metal ion transport
RU53_RS10580	COG1335	isochorismatase
RU53_RS10595	COG1012	belongs to the aldehyde dehydrogenase family
RU53_RS10610	COG4974	Belongs to the 'phage' integrase family
RU53_RS10635	COG3682	Transcriptional regulator
RU53_RS10680	COG1131	(ABC) transporter
RU53_RS10695	COG1725	Transcriptional regulator
RU53_RS10770	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RU53_RS10835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RU53_RS10840	COG1621	beta-fructofuranosidase activity
RU53_RS10845	COG1609	Transcriptional regulator
RU53_RS10850	COG0004	ammonium transporteR
RU53_RS10855	COG0425	Belongs to the sulfur carrier protein TusA family
RU53_RS10860	COG2391	methyltransferase activity
RU53_RS10870	COG0488	(ABC) transporter
RU53_RS10880	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
RU53_RS10890	COG0456	acetyltransferase
RU53_RS10895	COG1214	PFAM Peptidase M22, glycoprotease
RU53_RS10900	COG0802	atpase or kinase
RU53_RS10915	COG0028	Belongs to the TPP enzyme family
RU53_RS10985	COG2183	response to ionizing radiation
RU53_RS10990	COG1191	sigma factor activity
RU53_RS11000	COG1366	Belongs to the anti-sigma-factor antagonist family
RU53_RS11005	COG2208	phosphoserine phosphatase activity
RU53_RS11040	COG3428	Bacterial PH domain
RU53_RS11070	COG2205	protein histidine kinase activity
RU53_RS11075	COG0745	RESPONSE REGULATOR receiver
RU53_RS11085	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
RU53_RS11095	COG0772	Belongs to the SEDS family
RU53_RS11110	COG1937	Protein conserved in bacteria
RU53_RS11120	COG1418	mRNA catabolic process
RU53_RS11160	COG0629	single-stranded DNA binding
RU53_RS11235	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
RU53_RS11260	COG0009	L-threonylcarbamoyladenylate synthase
RU53_RS11265	COG2890	protein-(glutamine-N5) methyltransferase activity
RU53_RS11285	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
RU53_RS11325	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RU53_RS11375	COG0813	purine-nucleoside phosphorylase activity
RU53_RS11380	COG0783	Belongs to the Dps family
RU53_RS11400	COG1482	cell wall glycoprotein biosynthetic process
RU53_RS11405	COG0702	epimerase
RU53_RS11410	COG0640	Transcriptional regulator
RU53_RS11430	COG0561	phosphatase activity
RU53_RS11435	COG1119	ATPase activity
RU53_RS11450	COG3711	transcriptional antiterminator
RU53_RS11480	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
RU53_RS11540	COG0489	protein tyrosine kinase activity
RU53_RS11545	COG2814	Major facilitator Superfamily
RU53_RS11560	COG1272	protein, Hemolysin III
RU53_RS11570	COG1988	membrane-bound metal-dependent
RU53_RS11580	COG3314	Sporulation integral membrane protein YlbJ
RU53_RS11585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RU53_RS11590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RU53_RS11595	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
RU53_RS11605	COG3457	Alanine racemase
RU53_RS11610	COG4264	IucA IucC family
RU53_RS11615	COG2814	Major facilitator Superfamily
RU53_RS11640	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RU53_RS11650	COG2130	NADP-dependent
RU53_RS11700	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
RU53_RS11720	COG0656	L-ascorbic acid biosynthetic process
RU53_RS11725	COG0789	Transcriptional regulator
RU53_RS11735	COG5492	domain, Protein
RU53_RS11755	COG3527	Alpha-acetolactate decarboxylase
RU53_RS11760	COG0028	Belongs to the TPP enzyme family
RU53_RS11840	COG0201	protein transport
RU53_RS11955	COG2252	PERMEase
RU53_RS12000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RU53_RS12070	COG1763	Mo-molybdopterin cofactor biosynthetic process
RU53_RS12090	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RU53_RS12095	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
RU53_RS12100	COG4149	molybdate abc transporter
RU53_RS12105	COG0725	ABC transporter, periplasmic molybdate-binding protein
RU53_RS12120	COG1268	BioY protein
RU53_RS12135	COG1960	acyl-CoA dehydrogenase activity
RU53_RS12140	COG4413	Urea transporter
RU53_RS12215	COG1757	Na H antiporter
RU53_RS12230	COG3942	CHAP domain
RU53_RS12300	COG1113	amino acid transport
RU53_RS12320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RU53_RS12325	COG0385	Bile acid
RU53_RS12335	COG1263	PTS System
RU53_RS12335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RU53_RS12340	COG1737	Transcriptional regulator
RU53_RS12360	COG1028	Short-chain dehydrogenase reductase Sdr
RU53_RS12365	COG1473	amidohydrolase
RU53_RS12380	COG0583	DNA-binding transcription factor activity
RU53_RS12405	COG2258	MOSC domain
RU53_RS12425	COG1668	transmembrane transport
RU53_RS12430	COG4152	abc transporter atp-binding protein
RU53_RS12435	COG3152	Membrane
RU53_RS12445	COG0786	glutamate:sodium symporter activity
RU53_RS12455	COG0598	Magnesium transport protein CorA
RU53_RS12470	COG0657	acetylesterase activity
RU53_RS12480	COG2814	Major facilitator Superfamily
RU53_RS12485	COG1566	PFAM secretion protein HlyD family protein
RU53_RS12495	COG2814	Major facilitator Superfamily
RU53_RS12560	COG1620	l-lactate permease
RU53_RS12580	COG0604	alcohol dehydrogenase
RU53_RS12625	COG1511	domain protein
RU53_RS12640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RU53_RS12640	COG1263	PTS System
RU53_RS12655	COG3871	stress protein (general stress protein 26)
RU53_RS12700	COG0789	Transcriptional regulator
RU53_RS12720	COG2181	nitrate reductase activity
RU53_RS12730	COG1140	nitrate reductase beta subunit
RU53_RS12735	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
RU53_RS12745	COG2146	nitrite reductase [NAD(P)H] activity
RU53_RS12750	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RU53_RS12760	COG0454	-acetyltransferase
RU53_RS12765	COG2116	formate transmembrane transporter activity
RU53_RS12780	COG3443	Belongs to the bacterial solute-binding protein 9 family
RU53_RS12780	COG0803	Belongs to the bacterial solute-binding protein 9 family
RU53_RS12815	COG1126	abc transporter atp-binding protein
RU53_RS12820	COG0765	amino acid transport
RU53_RS12825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RU53_RS12830	COG2814	Major facilitator Superfamily
RU53_RS12845	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
RU53_RS12890	COG0156	8-amino-7-oxononanoate synthase activity
RU53_RS12900	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RU53_RS12905	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
RU53_RS12920	COG1132	(ABC) transporter
RU53_RS12925	COG2375	cellular response to nickel ion
RU53_RS12925	COG1132	(ABC) transporter
RU53_RS12945	COG1929	Belongs to the glycerate kinase type-1 family
RU53_RS12955	COG2814	Major facilitator Superfamily
RU53_RS12975	COG1113	amino acid transport
RU53_RS12990	COG0531	amino acid
RU53_RS13015	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
RU53_RS13025	COG1174	glycine betaine transport
RU53_RS13035	COG1174	glycine betaine transport
RU53_RS13055	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
RU53_RS13060	COG0531	amino acid
RU53_RS13065	COG2272	Belongs to the type-B carboxylesterase lipase family
RU53_RS13070	COG2814	Major facilitator Superfamily
RU53_RS13075	COG0390	transport system, permease component
RU53_RS13080	COG4619	ABC transporter
RU53_RS13085	COG1363	Peptidase, m42
RU53_RS13105	COG4808	Protein conserved in bacteria
RU53_RS13110	COG0069	glutamate synthase activity
RU53_RS13140	COG0601	transmembrane transport
RU53_RS13180	COG1028	Short-chain dehydrogenase reductase Sdr
RU53_RS13185	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
RU53_RS13190	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RU53_RS13260	COG0494	nUDIX hydrolase
RU53_RS13300	COG1846	Transcriptional regulator
RU53_RS13335	COG1070	Carbohydrate kinase
RU53_RS13340	COG1802	Transcriptional regulator
RU53_RS13345	COG0789	Transcriptional regulator
RU53_RS13350	COG2357	RelA SpoT domain protein
RU53_RS13355	COG4876	unkown
RU53_RS13365	COG2271	Major facilitator Superfamily
RU53_RS13370	COG0586	Pfam SNARE associated Golgi protein
RU53_RS13380	COG1131	(ABC) transporter
RU53_RS13400	COG3949	Membrane
RU53_RS13405	COG0400	carboxylic ester hydrolase activity
RU53_RS13410	COG0346	lactoylglutathione lyase activity
RU53_RS13415	COG1846	Transcriptional regulator
RU53_RS13425	COG2514	catechol 2,3-dioxygenase activity
RU53_RS13440	COG0561	phosphatase activity
RU53_RS13445	COG1131	(ABC) transporter
RU53_RS13455	COG3764	Sortase (surface protein transpeptidase)
RU53_RS13475	COG1760	l-serine dehydratase
RU53_RS13480	COG1760	l-serine dehydratase
RU53_RS13495	COG0697	spore germination
RU53_RS13500	COG0657	acetylesterase activity
RU53_RS13520	COG0028	Belongs to the TPP enzyme family
RU53_RS13535	COG0583	DNA-binding transcription factor activity
RU53_RS13545	COG3942	CHAP domain
RU53_RS13555	COG3425	synthase
RU53_RS13560	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RU53_RS13585	COG2409	Drug exporters of the RND superfamily
RU53_RS13630	COG0436	Aminotransferase
RU53_RS13660	COG3942	CHAP domain
RU53_RS13665	COG2755	lipolytic protein G-D-S-L family
RU53_RS13665	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
RU53_RS13735	COG0596	Alpha beta hydrolase
RU53_RS13770	COG3001	Fructosamine kinase
RU53_RS13775	COG0167	dihydroorotate dehydrogenase activity
RU53_RS13835	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
RU53_RS13840	COG3527	Alpha-acetolactate decarboxylase
RU53_RS13855	COG0531	amino acid
RU53_RS13885	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RU53_RS13905	COG1012	belongs to the aldehyde dehydrogenase family
RU53_RS13915	COG1510	regulation of RNA biosynthetic process
RU53_RS13925	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RU53_RS13950	COG2851	Citrate transporter
RU53_RS13960	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
RU53_RS13970	COG0386	Belongs to the glutathione peroxidase family
RU53_RS13995	COG1136	(ABC) transporter
RU53_RS14000	COG2205	protein histidine kinase activity
RU53_RS14005	COG0745	RESPONSE REGULATOR receiver
RU53_RS14020	COG1785	Belongs to the alkaline phosphatase family
RU53_RS14025	COG1846	Transcriptional regulator
RU53_RS14070	COG1438	arginine binding
RU53_RS14090	COG3711	transcriptional antiterminator
RU53_RS14090	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RU53_RS14095	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RU53_RS14095	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RU53_RS14095	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RU53_RS14100	COG1482	cell wall glycoprotein biosynthetic process
RU53_RS14110	COG3942	CHAP domain
RU53_RS14110	COG1705	Flagellar rod assembly protein muramidase FlgJ
RU53_RS14115	COG1535	isochorismatase
RU53_RS14115	COG3433	isochorismatase activity
RU53_RS14130	COG0438	transferase activity, transferring glycosyl groups
RU53_RS14145	COG1073	alpha beta
RU53_RS14165	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RU53_RS14190	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RU53_RS14250	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
RU53_RS14285	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RU53_RS14365	COG0471	metal ion transport
RU53_RS14370	COG2962	Rard protein
RU53_RS14380	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
RU53_RS14395	COG1136	(ABC) transporter
RU53_RS14400	COG0577	efflux transmembrane transporter activity
RU53_RS14430	COG1278	Cold shock
RU53_RS14450	COG1475	DNA binding