locus-tag	class	description
HMPREF0772_RS00250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HMPREF0772_RS00255	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HMPREF0772_RS00420	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HMPREF0772_RS00460	COG0070	glutamate synthase
HMPREF0772_RS00460	COG0069	glutamate synthase activity
HMPREF0772_RS00460	COG0067	glutamate synthase
HMPREF0772_RS00545	COG0733	neurotransmitter:sodium symporter activity
HMPREF0772_RS01405	COG1263	PTS System
HMPREF0772_RS01405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HMPREF0772_RS01405	COG2190	(PTS) system
HMPREF0772_RS01525	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HMPREF0772_RS01525	COG3711	transcriptional antiterminator
HMPREF0772_RS01560	COG0747	negative chemotaxis
HMPREF0772_RS01995	COG1012	belongs to the aldehyde dehydrogenase family
HMPREF0772_RS01995	COG1454	alcohol dehydrogenase
HMPREF0772_RS02000	COG1454	alcohol dehydrogenase
HMPREF0772_RS02000	COG1012	belongs to the aldehyde dehydrogenase family
HMPREF0772_RS02125	COG4264	IucA IucC family
HMPREF0772_RS02220	COG1473	amidohydrolase
HMPREF0772_RS02305	COG4268	DNA restriction-modification system
HMPREF0772_RS02875	COG1073	alpha beta
HMPREF0772_RS03105	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HMPREF0772_RS03150	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HMPREF0772_RS03660	COG2271	Major facilitator Superfamily
HMPREF0772_RS04205	COG2814	Major facilitator Superfamily
HMPREF0772_RS04300	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HMPREF0772_RS04550	COG2814	Major facilitator Superfamily
HMPREF0772_RS04580	COG0786	glutamate:sodium symporter activity
HMPREF0772_RS04705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HMPREF0772_RS04705	COG1263	PTS System
HMPREF0772_RS05105	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HMPREF0772_RS05380	COG2130	NADP-dependent
HMPREF0772_RS05445	COG4264	IucA IucC family
HMPREF0772_RS06380	COG0739	heme binding
HMPREF0772_RS06500	COG1131	(ABC) transporter
HMPREF0772_RS06945	COG1988	membrane-bound metal-dependent
HMPREF0772_RS07105	COG0114	fumarate hydratase activity
HMPREF0772_RS07375	COG5492	domain, Protein
HMPREF0772_RS07485	COG0656	L-ascorbic acid biosynthetic process
HMPREF0772_RS07860	COG4109	DRTGG domain
HMPREF0772_RS07990	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HMPREF0772_RS07990	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HMPREF0772_RS08155	COG1792	Involved in formation and maintenance of cell shape
HMPREF0772_RS08215	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HMPREF0772_RS08300	COG1104	cysteine desulfurase activity
HMPREF0772_RS08330	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HMPREF0772_RS08535	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HMPREF0772_RS08755	COG0095	Lipoate-protein ligase
HMPREF0772_RS08900	COG1609	Transcriptional regulator
HMPREF0772_RS08920	COG0366	Alpha amylase catalytic
HMPREF0772_RS08925	COG0366	Alpha amylase catalytic
HMPREF0772_RS08930	COG0366	Alpha amylase catalytic
HMPREF0772_RS09835	COG0573	inorganic phosphate transmembrane transporter activity
HMPREF0772_RS09950	COG0392	lysyltransferase activity
HMPREF0772_RS09950	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HMPREF0772_RS10710	COG0552	protein localization to endoplasmic reticulum
HMPREF0772_RS10800	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HMPREF0772_RS10800	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HMPREF0772_RS10815	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HMPREF0772_RS10825	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HMPREF0772_RS10830	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HMPREF0772_RS10905	COG0564	pseudouridine synthase activity
HMPREF0772_RS11835	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HMPREF0772_RS11935	COG2239	Acts as a magnesium transporter
HMPREF0772_RS11955	COG3025	triphosphatase activity
HMPREF0772_RS12040	COG4166	transmembrane transport
HMPREF0772_RS12255	COG2826	transposase and inactivated derivatives, IS30 family
HMPREF0772_RS12415	COG0737	Belongs to the 5'-nucleotidase family
HMPREF0772_RS12750	COG0557	exoribonuclease II activity
HMPREF0772_RS13005	COG4605	iron ion homeostasis
HMPREF0772_RS13470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF0772_RS13500	COG1132	(ABC) transporter
HMPREF0772_RS13600	COG0025	NhaP-type Na H and K H
HMPREF0772_RS14070	COG0640	Transcriptional regulator
HMPREF0772_RS14105	COG0577	efflux transmembrane transporter activity
HMPREF0772_RS14105	COG1136	(ABC) transporter
HMPREF0772_RS14140	COG3682	Transcriptional regulator