locus-tag class description CNH35_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CNH35_RS00015 ENOG410848D S4 domain protein YaaA CNH35_RS00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CNH35_RS00035 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) CNH35_RS00065 ENOG4105DWV Homoserine O-trans-acetylase CNH35_RS00075 ENOG4105BZR domain protein CNH35_RS00085 ENOG4105CDU Replicative dna helicase CNH35_RS00095 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis CNH35_RS00130 ENOG4105Q2H domain protein CNH35_RS00135 ENOG4105CGH 5'-nucleotidase CNH35_RS00170 ENOG41087NI Sulfite exporter TauE/SafE CNH35_RS00175 ENOG4105XTG Pfam:DUF156 CNH35_RS00180 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase CNH35_RS00185 ENOG4105C5X domain protein CNH35_RS00225 ENOG4108WS4 fmn reductase CNH35_RS00260 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C CNH35_RS00265 ENOG4106QP9 (LipO)protein CNH35_RS00270 ENOG4106QP9 (LipO)protein CNH35_RS00275 ENOG4106QP9 (LipO)protein CNH35_RS00285 ENOG41063ZK Transcriptional Regulator AraC Family CNH35_RS00295 ENOG4105C57 major facilitator superfamily CNH35_RS00305 ENOG4105CCI Myosin-Cross-Reactive Antigen CNH35_RS00310 ENOG4107Y9U Membrane CNH35_RS00345 ENOG4108IHU transport system permease protein CNH35_RS00350 ENOG4105DQ5 transport system permease protein CNH35_RS00355 ENOG4108MES Periplasmic binding protein CNH35_RS00365 ENOG4105CIF Ornithine Cyclodeaminase CNH35_RS00370 ENOG4105DJU Siderophore biosynthesis protein CNH35_RS00375 ENOG4105C6X Major Facilitator CNH35_RS00380 ENOG4105DBM Siderophore biosynthesis protein CNH35_RS00385 ENOG4105DUU IucA IucC family protein CNH35_RS00395 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) CNH35_RS00400 ENOG41067FT ParB-like nuclease domain CNH35_RS00420 ENOG4105CHR reductase CNH35_RS00430 ENOG4108IAJ Nad-dependent epimerase dehydratase CNH35_RS00440 ENOG4105CPK Glycosyl transferase (Group 1 CNH35_RS00475 ENOG4105D3A purine nucleoside phosphorylase DeoD-type CNH35_RS00480 ENOG4108J8C transporter major facilitator family protein CNH35_RS00485 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) CNH35_RS00520 ENOG4105CGH 5'-nucleotidase CNH35_RS00550 ENOG4108EKI Dehydrogenase CNH35_RS00575 ENOG4105C5E polysaccharide biosynthesis protein CNH35_RS00585 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase CNH35_RS00615 ENOG4105D3Q Sugar transferase CNH35_RS00630 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase CNH35_RS00640 ENOG4105WD1 Membrane CNH35_RS00650 ENOG4105PGM cation diffusion facilitator family transporter CNH35_RS00680 ENOG4105C1G acyl-Coa dehydrogenase CNH35_RS00685 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) CNH35_RS00720 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) CNH35_RS00730 ENOG4105C8Y Acetylornithine aminotransferase CNH35_RS00735 ENOG4105CWM branched-chain amino acid transport system II carrier protein CNH35_RS00740 ENOG4105D3W isochorismatase CNH35_RS00745 ENOG4107RA9 decarboxylase CNH35_RS00775 ENOG4105QEK Transcriptional regulator CNH35_RS00785 ENOG4105DZR Type I site-specific deoxyribonuclease CNH35_RS00810 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CNH35_RS00815 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CNH35_RS00825 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) CNH35_RS00860 ENOG4105EG2 ABC transporter, permease CNH35_RS00870 ENOG4105CK5 oxidoreductase CNH35_RS00880 ENOG4108WWS isoprenylcysteine carboxyl methyltransferase CNH35_RS00885 ENOG4105CXY transporter CNH35_RS00890 ENOG4107VQW regulatoR CNH35_RS00895 ENOG4105C2F Histidine kinase CNH35_RS00940 ENOG4105CHU acetyl-coa acetyltransferase CNH35_RS00945 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CNH35_RS00950 ENOG4105C1G acyl-Coa dehydrogenase CNH35_RS00955 ENOG4105CEY Amp-dependent synthetase and ligase CNH35_RS00960 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) CNH35_RS00970 ENOG4107RRN ABC transporter substrate-binding protein CNH35_RS00975 ENOG4105K78 MarR family Transcriptional regulator CNH35_RS01010 ENOG4105CI1 PTS System CNH35_RS01015 ENOG4105DU0 nucleoside hydrolase CNH35_RS01035 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) CNH35_RS01040 ENOG4105DT3 PTS system, galactitol-specific IIc component CNH35_RS01045 ENOG4105CPQ Dehydrogenase CNH35_RS01055 ENOG4105CPQ Dehydrogenase CNH35_RS01060 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) CNH35_RS01065 ENOG4105EJJ Dehydrogenase CNH35_RS01070 ENOG4107RZX Teichoic acid biosynthesis protein CNH35_RS01075 ENOG4107SJB teichoic acid biosynthesis CNH35_RS01085 ENOG4105EJJ Dehydrogenase CNH35_RS01090 ENOG4107RZX Teichoic acid biosynthesis protein CNH35_RS01135 ENOG4105CI1 PTS System CNH35_RS01140 ENOG4105CS2 ec 3.2.1.21 CNH35_RS01150 ENOG4105DVA methyltransferase CNH35_RS01170 ENOG4105EV1 Ribose uptake protein RbsU CNH35_RS01205 ENOG41061JJ Peptidase family M23 CNH35_RS01210 ENOG4105DA5 (ABC) transporter CNH35_RS01240 ENOG4105VRS hydrolase family 18 CNH35_RS01250 ENOG4106PAW secretion accessory protein EsaA YueB CNH35_RS01260 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) CNH35_RS01270 ENOG4105EC2 ftsk spoIIIe CNH35_RS01410 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family CNH35_RS01420 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) CNH35_RS01450 ENOG4105D9N nucleoside CNH35_RS01455 ENOG4107RJ1 sodium solute CNH35_RS01465 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) CNH35_RS01470 ENOG4106KNT transcriptional regulator CNH35_RS01480 ENOG4105DWD nucleoside recognition domain protein CNH35_RS01585 ENOG4106CVF DNA replication protein CNH35_RS01800 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis CNH35_RS01820 ENOG4105ZMJ n-acetylmuramoyl-l-alanine amidase CNH35_RS01850 ENOG4105DEN Luciferase family CNH35_RS01860 ENOG4108UVJ appr-1-p processing domain protein CNH35_RS01880 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC CNH35_RS01890 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia CNH35_RS01895 ENOG4105CID antiterminator CNH35_RS01920 ENOG4105CXY transporter CNH35_RS01935 ENOG4107V0Z fmn reductase CNH35_RS01940 ENOG4105HMI Membrane CNH35_RS01955 ENOG410650H (LipO)protein CNH35_RS01960 ENOG4105DBE peroxidase CNH35_RS01965 ENOG4107SJW iron permease, FTR1 CNH35_RS01970 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) CNH35_RS01975 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) CNH35_RS01985 ENOG4105VZ8 Transcriptional regulator CNH35_RS01995 ENOG4105DA5 (ABC) transporter CNH35_RS02030 ENOG4105C28 cystathionine CNH35_RS02035 ENOG4105C28 cystathionine CNH35_RS02045 ENOG4105FA0 parb-like partition protein CNH35_RS02050 ENOG4105D8X mechanosensitive ion channel CNH35_RS02055 ENOG4105VDK protein, conserved in bacteria CNH35_RS02060 ENOG4105C3G gtp-binding protein CNH35_RS02080 ENOG4108UUM single-stranded DNA-binding protein CNH35_RS02095 ENOG4108I7H Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CNH35_RS02155 ENOG4108JU3 Alkyl hydroperoxide reductase CNH35_RS02170 ENOG4107R6U sodium dicarboxylate symporter CNH35_RS02205 ENOG4105C2W permease CNH35_RS02245 ENOG4105KA3 membrAne CNH35_RS02410 ENOG4105CKI cobalamin synthesis protein CNH35_RS02440 ENOG4108TWJ NADH dehydrogenase subunit 5 CNH35_RS02445 ENOG4105EVH UPF0753 protein CNH35_RS02450 ENOG4105GPN Uncharacterized conserved protein (DUF2294) CNH35_RS02475 ENOG4105C8J )-transporter CNH35_RS02485 ENOG4105C28 cystathionine CNH35_RS02495 ENOG4108UMI ABC transporter, permease CNH35_RS02500 ENOG4105D01 (LipO)protein CNH35_RS02535 ENOG4105C5Q Transcriptional regulator CNH35_RS02540 ENOG4105CBC glutamate synthase CNH35_RS02545 ENOG4105BZ8 glutamate synthase CNH35_RS02555 ENOG4105C5Y PTS System CNH35_RS02560 ENOG4105CG3 alpha amylase, catalytic region CNH35_RS02565 ENOG4107414 GntR family transcriptional regulator CNH35_RS02585 ENOG4105C6E dna polymerase iii CNH35_RS02590 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) CNH35_RS02625 ENOG4105CXN decarboxylase CNH35_RS02635 ENOG4105X0R protein from nitrogen regulatory protein P-II CNH35_RS02640 ENOG4105FA2 dna polymerase iii CNH35_RS02645 ENOG4105MA4 psp1 domain protein CNH35_RS02655 ENOG41060K3 Methyltransferase CNH35_RS02665 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) CNH35_RS02670 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) CNH35_RS02675 ENOG4105F8V Hydrolase, tatD family CNH35_RS02680 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) CNH35_RS02690 ENOG4105W42 Veg protein CNH35_RS02700 ENOG4105DFT pur operon repressor CNH35_RS02705 ENOG4105KME endoribonuclease L-psp CNH35_RS02725 ENOG4105C5T Phosphoribosyl pyrophosphate synthase CNH35_RS02745 ENOG4108JA2 transcriptioN-repair coupling factor CNH35_RS02755 ENOG4108IY2 MazG family CNH35_RS02760 ENOG41082I2 s4 domain protein CNH35_RS02770 ENOG41060GV RNA binding s1 domain protein CNH35_RS02775 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) CNH35_RS02780 ENOG4108UGV hypoxanthine phosphoribosyltransferase CNH35_RS02785 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) CNH35_RS02795 ENOG4105C6T cysteine synthase CNH35_RS02805 ENOG4105KRF dihydroneopterin aldolase CNH35_RS02810 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase CNH35_RS02890 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CNH35_RS02905 ENOG4105D9N nucleoside CNH35_RS02915 ENOG4108Z0C Uvrb UvrC protein CNH35_RS02930 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) CNH35_RS02935 ENOG4105CTP PilT protein domain protein CNH35_RS02960 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) CNH35_RS02965 ENOG4105C2N RNA methyltransferase TrmH family group 3 CNH35_RS02985 ENOG410683Z Preprotein translocase SecE subunit CNH35_RS02990 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) CNH35_RS02995 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) CNH35_RS03020 ENOG4107Y49 methyltransferase CNH35_RS03030 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CNH35_RS03065 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) CNH35_RS03085 ENOG4105CM2 brancheD-chain amino acid aminotransferase CNH35_RS03095 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase CNH35_RS03100 ENOG4105ZMH deoxynucleoside kinase CNH35_RS03110 ENOG4108Z6B deaminase CNH35_RS03115 ENOG410667J hydrolase CNH35_RS03130 ENOG4105DUY Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein CNH35_RS03140 ENOG4105DUY Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein CNH35_RS03160 ENOG4107YEI lmbE family CNH35_RS03175 ENOG4108VA3 3-hexulose-6-phosphate synthase CNH35_RS03225 ENOG4105DWF phosphomethylpyrimidine kinase CNH35_RS03270 ENOG4108IJ2 phosphate acetyltransferase CNH35_RS03275 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) CNH35_RS03280 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) CNH35_RS03300 ENOG4107QN2 dihydrolipoyl dehydrogenase CNH35_RS03395 ENOG4105CPC Aldo Keto reductase CNH35_RS03400 ENOG4108WS4 fmn reductase CNH35_RS03410 ENOG4105DCI Phosphohydrolase CNH35_RS03415 ENOG4108XFG YwhD family CNH35_RS03450 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) CNH35_RS03455 ENOG4108IU2 vtamin B12-transporter permease CNH35_RS03465 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) CNH35_RS03505 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off CNH35_RS03545 ENOG4105EEQ Na H antiporter CNH35_RS03550 ENOG4105DSE periplasmic solute binding protein CNH35_RS03555 ENOG4105CC5 ABC transporter CNH35_RS03560 ENOG4105DIK (ABC) transporter CNH35_RS03565 ENOG4107R5H iron (metal) dependent repressor, dtxr family CNH35_RS03575 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family CNH35_RS03600 ENOG4107YSK Glycerol-3-phosphate cytidylyltransferase CNH35_RS03610 ENOG4105BZ1 (ABC) transporter CNH35_RS03625 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) CNH35_RS03630 ENOG4105E0A ABC, transporter CNH35_RS03635 ENOG4105DQ5 transport system permease protein CNH35_RS03640 ENOG4105EHG Permease protein CNH35_RS03645 ENOG4105CMT Dihydroxyacetone kinase CNH35_RS03655 ENOG4105VDH Dihydroxyacetone kinase CNH35_RS03665 ENOG4108K88 Membrane CNH35_RS03705 ENOG4105C19 ABC transporter CNH35_RS03715 ENOG4107GRR phosphate transport regulator CNH35_RS03720 ENOG4105CJ3 phosphate transporter CNH35_RS03725 ENOG4105VRS hydrolase family 18 CNH35_RS03735 ENOG4105ID8 Transcriptional regulator, ARAC family CNH35_RS03775 ENOG4105S8Q sugar efflux transporter CNH35_RS03780 ENOG4105SXS Protein of unknown function (DUF456) CNH35_RS03805 ENOG4108YYQ gCN5-related N-acetyltransferase CNH35_RS03810 ENOG4108URH decarboxylase CNH35_RS03830 ENOG4108JJ9 ABC, transporter CNH35_RS03835 ENOG4108JJ8 (ABC) transporter CNH35_RS03840 ENOG41083AI transcriptional regulator), MarR family CNH35_RS03845 ENOG4105CKI cobalamin synthesis protein CNH35_RS03850 ENOG4107QM2 Aldo Keto reductase CNH35_RS03860 ENOG4107QPK )-transporter CNH35_RS03865 ENOG4105CVP deoxyribo-dipyrimidine photolyase CNH35_RS03885 ENOG4105DP8 Major facilitator superfamily MFS_1 CNH35_RS03895 ENOG4108Z66 YbaK ebsC protein CNH35_RS03900 ENOG4105E98 transcriptional regulator DeoR family CNH35_RS03905 ENOG4105DE4 1-phosphofructokinase CNH35_RS03910 ENOG4105DM4 PTS System CNH35_RS03915 ENOG4105CE4 GlcNAc 6-P deacetylase CNH35_RS03920 ENOG4105C37 (CBS) domain CNH35_RS03930 ENOG4105CKK Glycosyl transferase, family 2 CNH35_RS03960 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) CNH35_RS03965 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase CNH35_RS03975 ENOG4105DDQ anthranilate synthase CNH35_RS03980 ENOG4105CRQ synthase (Component I) CNH35_RS04010 ENOG4105C5H ABC transporter CNH35_RS04015 ENOG4105C9U ATP-dependent DNA helicase RecQ CNH35_RS04020 ENOG4108IJ8 ABC transporter CNH35_RS04025 ENOG4105E90 ABC transporter CNH35_RS04035 ENOG4108ZIE 5 nucleotidase deoxy cytosolic type C CNH35_RS04055 ENOG4105DUX Transporter CNH35_RS04085 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CNH35_RS04090 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CNH35_RS04105 ENOG4105DHS permease protein CNH35_RS04110 ENOG4105CM4 permease protein CNH35_RS04115 ENOG4108IPW abc transporter atp-binding protein CNH35_RS04175 ENOG4105ESV Glycosyl transferase, family 4 CNH35_RS04180 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein CNH35_RS04195 ENOG41081UC Inherit from COG: Competence protein CNH35_RS04225 ENOG41068JE domain protein CNH35_RS04240 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) CNH35_RS04245 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CNH35_RS04260 ENOG4108S4C acetyltransferase CNH35_RS04270 ENOG4105C3M thioredoxin reductase CNH35_RS04285 ENOG4105CHW UPF0052 protein CNH35_RS04320 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CNH35_RS04335 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) CNH35_RS04350 ENOG4105XZU Preprotein translocase, subunit SecG CNH35_RS04360 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) CNH35_RS04430 ENOG4107Y9E nuclease CNH35_RS04435 ENOG4105VEQ Cold shock protein CNH35_RS04475 ENOG4105CVJ phosphoglycerate mutase CNH35_RS04480 ENOG4108ZUB Lysine exporter protein (Lyse ygga) CNH35_RS04505 ENOG4105SZ6 Thioredoxin CNH35_RS04510 ENOG41080E8 Transcriptional regulator, Spx MgsR family CNH35_RS04525 ENOG4108XI2 Domain of unknown function (DUF1963) CNH35_RS04550 ENOG4108UMI ABC transporter, permease CNH35_RS04555 ENOG4105D01 (LipO)protein CNH35_RS04570 ENOG4105C3K feS assembly ATPase SufC CNH35_RS04575 ENOG4105JRK feS assembly protein SufD CNH35_RS04580 ENOG4105C9B Cysteine desulfurase CNH35_RS04585 ENOG4108UNV SUF system FeS assembly protein, NifU family CNH35_RS04625 ENOG4105I3N Conserved Protein CNH35_RS04645 ENOG4105MMD transcriptional regulator CNH35_RS04685 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein CNH35_RS04695 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD CNH35_RS04700 ENOG41083MR nifu domain-containing protein CNH35_RS04730 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) CNH35_RS04740 ENOG4105KA0 thioesterase Superfamily protein CNH35_RS04795 ENOG41060GV RNA binding s1 domain protein CNH35_RS04800 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CNH35_RS04805 ENOG4105C8Y Acetylornithine aminotransferase CNH35_RS04810 ENOG4105D82 Glutamate dehydrogenase CNH35_RS04820 ENOG4107VXM glycerophosphoryl diester phosphodiesterase CNH35_RS04850 ENOG4105C3F Signal peptidase i CNH35_RS04855 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination CNH35_RS04860 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation CNH35_RS04880 ENOG4108KP7 hydrolase CNH35_RS04890 ENOG4105EXC Acyl-transferase CNH35_RS04895 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CNH35_RS04905 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) CNH35_RS04920 ENOG4105KIS phospholipid-binding protein CNH35_RS04940 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CNH35_RS04950 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CNH35_RS04955 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CNH35_RS04965 ENOG4108JQ7 (ABC) transporter CNH35_RS04975 ENOG4105DEF Extracellular solute-binding protein, family 5 CNH35_RS04985 ENOG4108JQ7 (ABC) transporter CNH35_RS04995 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CNH35_RS05000 ENOG4105C31 Tryptophanyl-tRNA synthetase CNH35_RS05005 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) CNH35_RS05020 ENOG4105DPN Oligoendopeptidase f CNH35_RS05025 ENOG4105T58 Dithiol-disulfide isomerase CNH35_RS05030 ENOG4108Z18 K06886 hemoglobin CNH35_RS05040 ENOG4106EFP UPF0738 protein CNH35_RS05055 ENOG4105EMS pseudouridine synthase CNH35_RS05060 ENOG4105CJW magnesium transporter CNH35_RS05075 ENOG4105C02 permease CNH35_RS05080 ENOG4105BZG amino acid carrier protein CNH35_RS05120 ENOG4107TS3 membrane protein, TerC CNH35_RS05125 ENOG4105C0H protease CNH35_RS05135 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic CNH35_RS05150 ENOG4105XVF Competence transcription factor CNH35_RS05200 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CNH35_RS05225 ENOG4108HUF Transporter CNH35_RS05235 ENOG4105YB8 TM2 domain containing protein CNH35_RS05240 ENOG41080E2 ribosomal-protein-alanine acetyltransferase CNH35_RS05245 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase CNH35_RS05255 ENOG4105E4F Isochorismate synthase CNH35_RS05265 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) CNH35_RS05270 ENOG4108IPT Naphthoate synthase CNH35_RS05285 ENOG4108CHM Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases CNH35_RS05290 ENOG4105CHM Aminotransferase CNH35_RS05295 ENOG4108TGC Acyltransferase CNH35_RS05310 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis CNH35_RS05315 ENOG41082BV acetyltransferase CNH35_RS05325 ENOG4108KGH TRANSCRIPTIONal CNH35_RS05330 ENOG4105FQP Beta-lactamase CNH35_RS05370 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) CNH35_RS05375 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit CNH35_RS05385 ENOG4105VR9 phosphoribosylformylglycinamidine synthase CNH35_RS05400 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase CNH35_RS05410 ENOG4108V3E phosphoribosylglycinamide formyltransferase CNH35_RS05420 ENOG4105C12 Phosphoribosylglycinamide synthetase CNH35_RS05425 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) CNH35_RS05430 ENOG4108JJB ABC transporter CNH35_RS05435 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein CNH35_RS05460 ENOG4105DR4 Methyltransferase CNH35_RS05470 ENOG4105KRI phosphocarrier protein (HPr CNH35_RS05475 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) CNH35_RS05495 ENOG4107ZYR domain protein CNH35_RS05515 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CNH35_RS05525 ENOG4107RUY (E1 component), alpha subunit CNH35_RS05530 ENOG4105CPP Dehydrogenase, E1 component CNH35_RS05535 ENOG4105C7S Dehydrogenase CNH35_RS05540 ENOG4107QN2 dihydrolipoyl dehydrogenase CNH35_RS05560 ENOG4105F38 ABC transporter, permease CNH35_RS05565 ENOG4105D38 putrescine abc transporter CNH35_RS05570 ENOG4107RUE extracellular solute-binding protein family 1 CNH35_RS05595 ENOG4105ECY inositol monophosphatase CNH35_RS05605 ENOG4105CI3 gtp-binding protein typa CNH35_RS05625 ENOG4105CNI cell division protein FtsW CNH35_RS05630 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) CNH35_RS05680 ENOG4106H78 methyltransferase CNH35_RS05795 ENOG4106CVF DNA replication protein CNH35_RS05895 ENOG4105IG6 Phage terminase, large subunit CNH35_RS06005 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis CNH35_RS06025 ENOG4105ZMJ n-acetylmuramoyl-l-alanine amidase CNH35_RS06060 ENOG4105KFN sortase, SrtB family CNH35_RS06075 ENOG4108RWN rrna methyltransferase CNH35_RS06085 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) CNH35_RS06110 ENOG4105DCG PHP domain protein CNH35_RS06135 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit CNH35_RS06145 ENOG4105E33 succinate dehydrogenase CNH35_RS06155 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) CNH35_RS06220 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity CNH35_RS06250 ENOG4105DBV ornithine carbamoyltransferase CNH35_RS06260 ENOG4105CSX c4-dicarboxylate anaerobic carrier CNH35_RS06315 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) CNH35_RS06320 ENOG41068DC Essential cell division protein (By similarity) CNH35_RS06325 ENOG4105CJN penicillin-binding protein CNH35_RS06340 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) CNH35_RS06345 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) CNH35_RS06350 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) CNH35_RS06355 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase CNH35_RS06360 ENOG4105DFA alanine racemase domain protein CNH35_RS06370 ENOG41067XK integral membrane protein CNH35_RS06375 ENOG4105DBK s4 domain protein CNH35_RS06390 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase CNH35_RS06410 ENOG4105C34 Pseudouridine synthase CNH35_RS06430 ENOG4105CD3 dihydroorotase CNH35_RS06435 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain CNH35_RS06450 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) CNH35_RS06465 ENOG4105F23 Fibronectin-binding protein CNH35_RS06480 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase CNH35_RS06485 ENOG4105C25 Primosomal protein n' CNH35_RS06495 ENOG4105YB8 TM2 domain containing protein CNH35_RS06500 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CNH35_RS06510 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B CNH35_RS06520 ENOG4108ZF3 Phosphatase CNH35_RS06530 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) CNH35_RS06535 ENOG4105DJV ribulose-phosphate 3-epimerase CNH35_RS06550 ENOG4108ZAA Alkaline-shock protein CNH35_RS06560 ENOG4105CB5 ATP-dependent DNA helicase recG CNH35_RS06575 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase CNH35_RS06580 ENOG4105CHR reductase CNH35_RS06600 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) CNH35_RS06605 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) CNH35_RS06645 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) CNH35_RS06660 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha CNH35_RS06665 ENOG41068KG domain protein CNH35_RS06675 ENOG4105C79 DNA protecting protein DprA CNH35_RS06740 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) CNH35_RS06745 ENOG4105KNE Phosphatidate cytidylyltransferase CNH35_RS06750 ENOG4105DZP Membrane-associated zinc metalloprotease CNH35_RS06775 ENOG4105CHV Transcription elongation factor NusA CNH35_RS06780 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination CNH35_RS06805 ENOG4105DTN riboflavin biosynthesis protein ribF CNH35_RS06830 ENOG4105CNU cell division protein FtsK CNH35_RS06835 ENOG4105FDP GntR family transcriptional regulator CNH35_RS06850 ENOG4108RKS Short-chain dehydrogenase reductase Sdr CNH35_RS06865 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase CNH35_RS06870 ENOG4105CEV competence damage-inducible protein CNH35_RS06890 ENOG4105D48 metallophosphoesterase CNH35_RS06895 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein CNH35_RS06900 ENOG4105DQU oxidoreductase, subunit beta CNH35_RS06935 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator CNH35_RS06940 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) CNH35_RS06965 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) CNH35_RS06970 ENOG4108V06 Glutathione peroxidase CNH35_RS06975 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CNH35_RS06980 ENOG4105CXI aluminum resistance protein CNH35_RS06985 ENOG4105KV4 Transcriptional regulator CNH35_RS06990 ENOG4105C5F glutamine synthetase CNH35_RS07100 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CNH35_RS07105 ENOG4108M15 ABC transporter CNH35_RS07120 ENOG4108S01 response regulator CNH35_RS07145 ENOG4105CFH Aspartokinase CNH35_RS07150 ENOG4105D6E homoserine dehydrogenase CNH35_RS07155 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) CNH35_RS07180 ENOG4108IQI permease CNH35_RS07210 ENOG4105K4I Scp-like extracellular CNH35_RS07230 ENOG4105CV1 Transketolase (EC 2.2.1.1) CNH35_RS07255 ENOG4105EYH Exonuclease CNH35_RS07265 ENOG4105C94 Transporter CNH35_RS07275 ENOG4108I0Z Aconitate hydratase CNH35_RS07305 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CNH35_RS07310 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CNH35_RS07340 ENOG4105FF5 Membrane CNH35_RS07345 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) CNH35_RS07350 ENOG4108RCF TRANSCRIPTIONal CNH35_RS07360 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CNH35_RS07370 ENOG4105DER m42 family CNH35_RS07375 ENOG4105CRQ synthase (Component I) CNH35_RS07380 ENOG4105DDQ anthranilate synthase CNH35_RS07390 ENOG4105DK0 Indole-3-glycerol phosphate synthase CNH35_RS07410 ENOG4108RMH femAB family CNH35_RS07415 ENOG4108TV1 Catalyzes the incorporation of amino acid(s) into the interchain peptide bridge of peptidoglycan, using aminoacyl-tRNA as amino acid donor (By similarity) CNH35_RS07420 ENOG4108KP7 hydrolase CNH35_RS07460 ENOG4105DPN Oligoendopeptidase f CNH35_RS07465 ENOG4108UTW Plays a role in the regulation of phosphate uptake CNH35_RS07475 ENOG4105E2Z phosphate ABC transporter (Permease CNH35_RS07480 ENOG4105C8U phosphate abc transporter CNH35_RS07500 ENOG4105C5H ABC transporter CNH35_RS07505 ENOG4105CFH Aspartokinase CNH35_RS07510 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CNH35_RS07535 ENOG4108XFP Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CNH35_RS07540 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) CNH35_RS07590 ENOG4107T89 von Willebrand factor, type A CNH35_RS07640 ENOG410841Q phosphoesterase PA-phosphatase related protein CNH35_RS07645 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) CNH35_RS07655 ENOG4105CN1 protease CNH35_RS07665 ENOG4105C5Y PTS System CNH35_RS07675 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) CNH35_RS07685 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) CNH35_RS07700 ENOG4106QQ5 PBS lyase HEAT domain protein repeat-containing protein CNH35_RS07740 ENOG4107R7I amino acid CNH35_RS07760 ENOG410890F Dynamin family CNH35_RS07775 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) CNH35_RS07815 ENOG4105BZ4 penicillin-binding protein CNH35_RS07825 ENOG4105CSM endonuclease III CNH35_RS07850 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate CNH35_RS07855 ENOG4105CPK Glycosyl transferase (Group 1 CNH35_RS07860 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase CNH35_RS07910 ENOG4105EAH synthase CNH35_RS07930 ENOG4105K70 DNA-binding protein CNH35_RS07945 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) CNH35_RS07970 ENOG4105HDK L-asparaginase CNH35_RS07975 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase CNH35_RS07990 ENOG4105C9U ATP-dependent DNA helicase RecQ CNH35_RS08045 ENOG4105BZU Histidine kinase CNH35_RS08050 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CNH35_RS08055 ENOG4105FE9 pseudouridine synthase CNH35_RS08075 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CNH35_RS08080 ENOG4105I3K Ferric uptake regulator, Fur family CNH35_RS08085 ENOG4108YZ4 nudix hydrolase CNH35_RS08090 ENOG4105CPC Aldo Keto reductase CNH35_RS08100 ENOG4105PDP Short chain dehydrogenase CNH35_RS08105 ENOG4105II7 pyrroline-5-carboxylate reductase CNH35_RS08115 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase CNH35_RS08145 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) CNH35_RS08150 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) CNH35_RS08160 ENOG4108QEG Membrane CNH35_RS08170 ENOG4105C7S Dehydrogenase CNH35_RS08175 ENOG4105CPP Dehydrogenase, E1 component CNH35_RS08190 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) CNH35_RS08220 ENOG4108ZSR alkaline shock protein CNH35_RS08225 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CNH35_RS08240 ENOG4105DC7 peptidase M24 CNH35_RS08255 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) CNH35_RS08260 ENOG4105WZW rhodanese family CNH35_RS08265 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor CNH35_RS08280 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) CNH35_RS08305 ENOG4106855 Competence protein CNH35_RS08310 ENOG4105D7Q type ii secretion system CNH35_RS08320 ENOG4105C5X domain protein CNH35_RS08345 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase CNH35_RS08355 ENOG4107RF6 penicillin-binding protein CNH35_RS08365 ENOG4105N80 Ferric uptake regulator, Fur family CNH35_RS08370 ENOG4105FAV ABC, transporter CNH35_RS08375 ENOG4105FDK ABC transporter CNH35_RS08385 ENOG4105C1J atp-dependent rna helicase CNH35_RS08390 ENOG4105EGD dinuclear metal center protein, YbgI family CNH35_RS08400 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CNH35_RS08405 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) CNH35_RS08435 ENOG4105KG3 cytidine deaminase CNH35_RS08450 ENOG4105C9A Phoh family CNH35_RS08465 ENOG4105F7J membrane-bound serine protease CNH35_RS08475 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) CNH35_RS08480 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) CNH35_RS08510 ENOG4105CSA Coproporphyrinogen iii oxidase CNH35_RS08530 ENOG4105TQK DNA polymerase iii, delta' subunit CNH35_RS08535 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 CNH35_RS08540 ENOG4108UK2 deaminase CNH35_RS08550 ENOG4105DXX methyltransferase CNH35_RS08555 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) CNH35_RS08560 ENOG4108WF2 Metal Dependent Phosphohydrolase CNH35_RS08570 ENOG410812S Rna-binding protein CNH35_RS08580 ENOG4105CQW ribosome biogenesis GTPase YqeH CNH35_RS08585 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase CNH35_RS08610 ENOG4105C5A transporter CNH35_RS08620 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CNH35_RS08625 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein CNH35_RS08635 ENOG4105P4J Allophanate hydrolase, subunit 1 CNH35_RS08650 ENOG4105CFP Peptidase U32 CNH35_RS08655 ENOG4105XYU peptidase (U32 family) CNH35_RS08685 ENOG4105C7H Helicase, RecD TraA family CNH35_RS08700 ENOG4105C3J Cysteine desulfurase CNH35_RS08705 ENOG4105DEN Luciferase family CNH35_RS08725 ENOG4105D1H recombination factor protein RarA CNH35_RS08730 ENOG4105CUZ uba thif-type nad fad binding protein CNH35_RS08775 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) CNH35_RS08780 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CNH35_RS08785 ENOG4105VIE preprotein translocase, subunit YajC CNH35_RS08825 ENOG4105X36 (ribosomal) protein CNH35_RS08870 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) CNH35_RS08880 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase CNH35_RS08890 ENOG4108R3E Dna-3-methyladenine glycosylase i CNH35_RS08910 ENOG4105D52 delta-aminolevulinic acid dehydratase CNH35_RS08960 ENOG4105U6W MutT NUDIX family protein CNH35_RS08985 ENOG4108IQI permease CNH35_RS09015 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CNH35_RS09025 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) CNH35_RS09030 ENOG4105C2M dna polymerase I CNH35_RS09040 ENOG4105BZU Histidine kinase CNH35_RS09045 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CNH35_RS09055 ENOG4108HMX isocitrate dehydrogenase (NADP) CNH35_RS09060 ENOG4105BZN citrate synthase CNH35_RS09065 ENOG4105C85 amino acid CNH35_RS09095 ENOG4105C6K Malic enzyme CNH35_RS09100 ENOG4105C0B DNA polymerase III (alpha subunit) CNH35_RS09105 ENOG4105SFS phosphoesterase RecJ domain protein CNH35_RS09160 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) CNH35_RS09210 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CNH35_RS09215 ENOG4108X3M OsmC Ohr family protein CNH35_RS09220 ENOG4105C5R Aminotransferase CNH35_RS09225 ENOG4108JQ1 Dehydrogenase CNH35_RS09245 ENOG4105F6E Acyl-transferase CNH35_RS09250 ENOG4105C0H protease CNH35_RS09290 ENOG4105F1V Acetoin utilization protein CNH35_RS09295 ENOG4105DGU Histone deacetylase CNH35_RS09300 ENOG4105ETE Transcriptional regulator (LacI family CNH35_RS09310 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase CNH35_RS09340 ENOG4108VDD TRNA binding domain protein CNH35_RS09365 ENOG4105C8F Beta-lactamase domain protein CNH35_RS09370 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) CNH35_RS09375 ENOG4108V15 phosphotransferase enzyme family CNH35_RS09380 ENOG4105F0I Aminotransferase CNH35_RS09410 ENOG4105CBX hi0933 family CNH35_RS09430 ENOG410605W Major Facilitator CNH35_RS09435 ENOG4105N5T Radical SAM Protein CNH35_RS09455 ENOG4105E8V Alpha Beta Hydrolase Fold protein CNH35_RS09480 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) CNH35_RS09485 ENOG4108R6K riboflavin synthase, subunit alpha CNH35_RS09490 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) CNH35_RS09505 ENOG4107R3E Citrate transporter CNH35_RS09515 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis CNH35_RS09545 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) CNH35_RS09555 ENOG4106A8V Protein CrcB homolog CNH35_RS09560 ENOG4106A8V Protein CrcB homolog CNH35_RS09570 ENOG4105CV8 reductase CNH35_RS09590 ENOG4108RS6 transposase CNH35_RS09720 ENOG4108CHM Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases CNH35_RS09775 ENOG4105DA5 (ABC) transporter CNH35_RS09895 ENOG4105C1Q protoporphyrinogen oxidase CNH35_RS09930 ENOG4105K59 histidine triad (HIT) protein CNH35_RS09965 ENOG4107VRP DNA repair exonuclease CNH35_RS09995 ENOG4105WH1 Two component transcriptional regulator luxr family CNH35_RS10000 ENOG4105BZU Histidine kinase CNH35_RS10005 ENOG4108YBP pseudouridine synthase CNH35_RS10010 ENOG4105C9Q fumarate hydratase class II CNH35_RS10045 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) CNH35_RS10050 ENOG4105CDA abc transporter atp-binding protein CNH35_RS10055 ENOG4105E5Q amino acid AbC transporter CNH35_RS10235 ENOG4108M3J Dehydrogenase CNH35_RS10240 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CNH35_RS10250 ENOG4107NBY Membrane CNH35_RS10275 ENOG41067AE Membrane-bound metal-dependent hydrolase CNH35_RS10290 ENOG4105EY8 ABC transporter CNH35_RS10330 ENOG4105ZMJ n-acetylmuramoyl-l-alanine amidase CNH35_RS10350 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis CNH35_RS10460 ENOG4105IG6 Phage terminase, large subunit CNH35_RS10560 ENOG4106CVF DNA replication protein CNH35_RS10635 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) CNH35_RS10650 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CNH35_RS10660 ENOG4108S4H thioesterase Superfamily protein CNH35_RS10685 ENOG4107U9T Pfam:Ribonuclease_BN CNH35_RS10690 ENOG4105WH1 Two component transcriptional regulator luxr family CNH35_RS10695 ENOG4105ENE Histidine kinase CNH35_RS10770 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CNH35_RS10780 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CNH35_RS10830 ENOG4105C4R Atp-dependent dna helicase CNH35_RS10835 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) CNH35_RS10840 ENOG4105KGF protein, YerC YecD CNH35_RS10855 ENOG4107DDB Cysteine protease able to CNH35_RS10880 ENOG4105DAP Nicotinate phosphoribosyltransferase CNH35_RS10885 ENOG4107QN4 Catalyzes the production of nitric oxide (By similarity) CNH35_RS10890 ENOG4105CQC Prephenate dehydratase CNH35_RS10900 ENOG4105C8P )-transporter CNH35_RS10925 ENOG4105C26 Dehydrogenase CNH35_RS10980 ENOG4105CJ1 ABC, transporter CNH35_RS10995 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family CNH35_RS11025 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) CNH35_RS11055 ENOG4105ZMJ n-acetylmuramoyl-l-alanine amidase CNH35_RS11070 ENOG4105ZMJ n-acetylmuramoyl-l-alanine amidase CNH35_RS11125 ENOG4105DR5 peptidase CNH35_RS11175 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CNH35_RS11225 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) CNH35_RS11350 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) CNH35_RS11410 ENOG4105CZN Potassium uptake protein CNH35_RS11430 ENOG4108TFU terminase (Small subunit) CNH35_RS11470 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase CNH35_RS11495 ENOG4108WCX response regulator CNH35_RS11520 ENOG4105BZU Histidine kinase CNH35_RS11530 ENOG4105CUC YeeE YedE family protein CNH35_RS11540 ENOG4105C5H ABC transporter CNH35_RS11550 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) CNH35_RS11560 ENOG410801F ribosomal-protein-alanine acetyltransferase CNH35_RS11565 ENOG41072GX Peptidase M22 Glycoprotease CNH35_RS11570 ENOG4105K8N protein family UPF0079, ATPase CNH35_RS11580 ENOG4105C01 Dihydroxy-acid dehydratase CNH35_RS11585 ENOG4105C7K acetolactate synthase CNH35_RS11675 ENOG4105WN5 stage II sporulation protein CNH35_RS11680 ENOG4107SGM protein serine threonine phosphatase CNH35_RS11700 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CNH35_RS11715 ENOG4105CKV Membrane CNH35_RS11725 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) CNH35_RS11730 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) CNH35_RS11745 ENOG4105C08 Histidine kinase CNH35_RS11750 ENOG4105EEX Two component transcriptional regulator (Winged helix family CNH35_RS11760 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) CNH35_RS11785 ENOG4105VPX protein, conserved in bacteria CNH35_RS11790 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CNH35_RS11830 ENOG4105DWF phosphomethylpyrimidine kinase CNH35_RS11860 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CNH35_RS11890 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) CNH35_RS11920 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase CNH35_RS11945 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CNH35_RS11950 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) CNH35_RS11975 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) CNH35_RS11995 ENOG4105D2N Aldolase CNH35_RS12060 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) CNH35_RS12065 ENOG4105D3A purine nucleoside phosphorylase DeoD-type CNH35_RS12070 ENOG4108RMU ferritin dps family protein CNH35_RS12090 ENOG4105DG6 mannose-6-phosphate isomerase CNH35_RS12105 ENOG4105PGM cation diffusion facilitator family transporter CNH35_RS12140 ENOG4105DKW ABC transporter CNH35_RS12145 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) CNH35_RS12150 ENOG4105CTS PTS system mannitol-specific CNH35_RS12155 ENOG4105ETD TRANSCRIPTIONal CNH35_RS12160 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein CNH35_RS12185 ENOG4105C8B TIGR00159 family CNH35_RS12190 ENOG4105CYW agmatinase CNH35_RS12260 ENOG4105D1F ATP-binding protein CNH35_RS12280 ENOG4108UT2 hemolysin iii CNH35_RS12290 ENOG4107K5X Membrane-bound metal-dependent hydrolase CNH35_RS12300 ENOG4105DWD nucleoside recognition domain protein CNH35_RS12305 ENOG4108U1V ABC transporter, permease CNH35_RS12310 ENOG4105DQ5 transport system permease protein CNH35_RS12315 ENOG4108HUF Transporter CNH35_RS12325 ENOG4106M28 alanine racemase domain protein CNH35_RS12335 ENOG4107SFI Major Facilitator superfamily CNH35_RS12365 ENOG4105C94 Transporter CNH35_RS12370 ENOG4105CIS alcohol dehydrogenase CNH35_RS12375 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein CNH35_RS12390 ENOG4105CK1 PTS System CNH35_RS12395 ENOG4105VCP PTS System CNH35_RS12415 ENOG4105E98 transcriptional regulator DeoR family CNH35_RS12420 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) CNH35_RS12445 ENOG4105VUF Transcriptional regulator CNH35_RS12455 ENOG4106AM8 polysaccharide lyase family 8 CNH35_RS12475 ENOG4107FQX Alpha-acetolactate decarboxylase CNH35_RS12500 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CNH35_RS12580 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) CNH35_RS12585 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) CNH35_RS12700 ENOG4105C7N Xanthine uracil vitamin C permease CNH35_RS12720 ENOG4105CSC Glucose uptake protein CNH35_RS12815 ENOG4108ZAF Molybdopterin CNH35_RS12820 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein CNH35_RS12825 ENOG4105CVM Molybdenum cofactor synthesis domain protein CNH35_RS12835 ENOG4105EPU Molybdenum cofactor synthesis domain protein CNH35_RS12840 ENOG4105D06 uba thif-type nad fad binding protein CNH35_RS12845 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) CNH35_RS12850 ENOG4105E0C molybdate abc transporter CNH35_RS12855 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein CNH35_RS12870 ENOG4107ZYJ bioY protein CNH35_RS12885 ENOG4105FDT acyl-CoA dehydrogenase CNH35_RS12955 ENOG41068JE domain protein CNH35_RS12965 ENOG4105DFD Na H antiporter CNH35_RS13000 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis CNH35_RS13075 ENOG4107YBY Hydrolase CNH35_RS13080 ENOG4105C09 Bile acid CNH35_RS13090 ENOG4105CI1 PTS System CNH35_RS13095 ENOG4108Q3X Transcriptional regulator CNH35_RS13115 ENOG4105CYX Short-chain dehydrogenase reductase Sdr CNH35_RS13120 ENOG4105CH2 amidohydrolase CNH35_RS13130 ENOG4105CGP Urocanate hydratase CNH35_RS13135 ENOG4105C5Q Transcriptional regulator CNH35_RS13150 ENOG4106E7R Lysostaphin resistance protein A CNH35_RS13155 ENOG4105E66 phosphoriboisomerase A CNH35_RS13160 ENOG4108RPX mosc domain containing protein CNH35_RS13180 ENOG4105RHA ABC transporter, permease CNH35_RS13185 ENOG4108IUX (ABC) transporter CNH35_RS13190 ENOG4105KAF membrAne CNH35_RS13205 ENOG4105D6U Sodium Glutamate Symporter CNH35_RS13215 ENOG4105D7N magnesium and cobalt transport protein CorA CNH35_RS13240 ENOG4105C0R drug resistance transporter emrb qaca subfamily CNH35_RS13245 ENOG4105CW7 secretion protein, HlyD family CNH35_RS13275 ENOG41062A4 Transcriptional regulator CNH35_RS13300 ENOG4105EFI regulatoR CNH35_RS13320 ENOG4105DWT malate dehydrogenase (quinone) CNH35_RS13350 ENOG4105KEG ribosomal-protein-alanine acetyltransferase CNH35_RS13375 ENOG4105ECB domain protein CNH35_RS13405 ENOG410606W general stress protein CNH35_RS13450 ENOG4107TXC Transcriptional regulator CNH35_RS13480 ENOG4108IUE nitrate reductase beta subunit CNH35_RS13490 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CNH35_RS13495 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit CNH35_RS13500 ENOG4108IFG nitrite reductase, (NAD(P)H) CNH35_RS13510 ENOG4108XSB acetyltransferase, (GNAT) family CNH35_RS13515 ENOG4105TMB Formate nitrite transporter CNH35_RS13530 ENOG4105DSE periplasmic solute binding protein CNH35_RS13570 ENOG4105CDA abc transporter atp-binding protein CNH35_RS13575 ENOG4105DRP amino acid AbC transporter CNH35_RS13580 ENOG4105EAB amino acid AbC transporter CNH35_RS13640 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) CNH35_RS13655 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) CNH35_RS13665 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CNH35_RS13670 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) CNH35_RS13685 ENOG4105BZ1 (ABC) transporter CNH35_RS13710 ENOG4105BZW Glycerate kinase CNH35_RS13720 ENOG4105C2C drug resistance transporter, Bcr CflA CNH35_RS13740 ENOG4105C85 amino acid CNH35_RS13745 ENOG4105EEQ Na H antiporter CNH35_RS13755 ENOG4105C0X amino acid CNH35_RS13765 ENOG4105ED2 Beta-lactamase CNH35_RS13780 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) CNH35_RS13785 ENOG4105C57 major facilitator superfamily CNH35_RS13790 ENOG4105R40 Glycine betaine carnitine choline CNH35_RS13800 ENOG4105E90 ABC transporter CNH35_RS13820 ENOG4105CZ9 Domain of unknown function (DU1801) CNH35_RS13830 ENOG4107QTZ amino acid CNH35_RS13835 ENOG4105EBR Carboxylesterase CNH35_RS13840 ENOG4105F27 Major Facilitator CNH35_RS13845 ENOG4105C4B ABC transporter, permease CNH35_RS13850 ENOG41083J0 (ABC) transporter CNH35_RS13855 ENOG4105CN9 Peptidase m42 family protein CNH35_RS13875 ENOG4105PQ4 (LipO)protein CNH35_RS13880 ENOG4105CBC glutamate synthase CNH35_RS13895 ENOG4108S9F abc transporter, atp-binding protein CNH35_RS13900 ENOG4108RZA ABC transporter CNH35_RS13905 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CNH35_RS13910 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CNH35_RS13915 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein CNH35_RS13945 ENOG4105CFC Transporter CNH35_RS13950 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) CNH35_RS14040 ENOG4105M6F mutator MutT protein CNH35_RS14075 ENOG4108M1Z surface protein CNH35_RS14120 ENOG4105CMG Carbohydrate kinase CNH35_RS14125 ENOG4105G3Z GntR family transcriptional regulator CNH35_RS14140 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) CNH35_RS14150 ENOG4105DJB Major Facilitator Superfamily CNH35_RS14155 ENOG4107T5V SNARE associated Golgi CNH35_RS14185 ENOG4105CJ1 ABC, transporter CNH35_RS14205 ENOG4105FBA Phospholipase Carboxylesterase CNH35_RS14215 ENOG41090MY MarR family Transcriptional regulator CNH35_RS14225 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase CNH35_RS14235 ENOG4105C5I Dehydrogenase CNH35_RS14240 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) CNH35_RS14245 ENOG4108Z15 abc transporter atp-binding protein CNH35_RS14250 ENOG4106KKU CNH35_RS14255 ENOG4108Z6X (sortase) family CNH35_RS14260 ENOG4108Z7F N-acetyltransferase CNH35_RS14275 ENOG4105EJQ L-serine dehydratase CNH35_RS14295 ENOG4108UZ3 Transporter CNH35_RS14325 ENOG41067MG lrgb family CNH35_RS14335 ENOG4105CMU LysR family (Transcriptional regulator CNH35_RS14345 ENOG41068JE domain protein CNH35_RS14370 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase CNH35_RS14375 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CNH35_RS14390 ENOG4105CE1 Ferrous iron transport protein b CNH35_RS14400 ENOG4105EYF MMPL domain protein CNH35_RS14420 ENOG4108UW5 maltose o-acetyltransferase CNH35_RS14430 ENOG4105C59 p-type ATPase CNH35_RS14475 ENOG41068JE domain protein CNH35_RS14480 ENOG4105EXC Acyl-transferase CNH35_RS14540 ENOG4105CHR reductase CNH35_RS14550 ENOG4108SXP alpha beta CNH35_RS14565 ENOG4107T5J pyridine nucleotide-disulfide oxidoreductase CNH35_RS14590 ENOG4105FGM Fructosamine kinase CNH35_RS14595 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) CNH35_RS14645 ENOG4108NKJ Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) CNH35_RS14650 ENOG4107FQX Alpha-acetolactate decarboxylase CNH35_RS14665 ENOG4105CUB amino acid CNH35_RS14670 ENOG4108JPW Aminotransferase CNH35_RS14685 ENOG4105DWT malate dehydrogenase (quinone) CNH35_RS14695 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) CNH35_RS14715 ENOG4105C26 Dehydrogenase CNH35_RS14725 ENOG4105TRT Transcriptional regulator CNH35_RS14735 ENOG4105C94 Transporter CNH35_RS14750 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) CNH35_RS14755 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase CNH35_RS14760 ENOG4105D4T Citrate transporter CNH35_RS14770 ENOG4108Z73 Siroheme synthase CNH35_RS14775 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) CNH35_RS14830 ENOG4105G6Z alkaline phosphatase CNH35_RS14840 ENOG4108U05 Transcriptional regulator CNH35_RS14850 ENOG4105T6C Cell surface-associated protein implicated in virulence by promoting bacterial attachment to both alpha- and beta-chains of human fibrinogen and inducing the formation of bacterial clumps CNH35_RS14870 ENOG4105DBV ornithine carbamoyltransferase CNH35_RS14875 ENOG4105CEU Arginine dihydrolase CNH35_RS14910 ENOG4105DM4 PTS System CNH35_RS14915 ENOG4105DG6 mannose-6-phosphate isomerase CNH35_RS14925 ENOG4108S4A n-acetylmuramoyl-l-alanine amidase CNH35_RS14930 ENOG4105WQI isochorismatase CNH35_RS14955 ENOG4106E62 Accessory Sec system protein Asp3 CNH35_RS14960 ENOG41089G2 accessory Sec system protein Asp2 CNH35_RS14965 ENOG4108XJK accessory Sec system protein Asp1 CNH35_RS14970 ENOG4106YAG Part of the accessory SecA2 SecY2 system specifically required for export of CNH35_RS14980 ENOG4105EW6 flavin reductase domain protein, FMN-binding CNH35_RS15000 ENOG4107XC4 flavin reductase domain protein, FMN-binding CNH35_RS15005 ENOG4108F19 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) CNH35_RS15025 ENOG4105HTX biosynthesis protein CNH35_RS15030 ENOG4108IG5 Transcriptional regulator CNH35_RS15035 ENOG4107QJZ Glycosyl transferase, family 2 CNH35_RS15045 ENOG4107UVV polysaccharide deacetylase CNH35_RS15060 ENOG4105J1V Triacylglycerol lipase CNH35_RS15070 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase CNH35_RS15085 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) CNH35_RS15095 ENOG4105CIH Imidazole acetol-phosphate transaminase CNH35_RS15100 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) CNH35_RS15130 ENOG4108JJB ABC transporter CNH35_RS15180 ENOG4107QPK )-transporter CNH35_RS15185 ENOG4105FR1 rard protein CNH35_RS15195 ENOG4105D9G High-affinity CNH35_RS15210 ENOG4105C19 ABC transporter CNH35_RS15265 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity)