locus-tag	class	description
I6G39_RS00015	COG4145	pantothenate transmembrane transporter activity
I6G39_RS00020	COG2348	transferase activity, transferring amino-acyl groups
I6G39_RS00030	COG0488	(ABC) transporter
I6G39_RS00050	COG1132	(ABC) transporter
I6G39_RS00055	COG2375	cellular response to nickel ion
I6G39_RS00055	COG1132	(ABC) transporter
I6G39_RS00060	COG1129	ABC transporter
I6G39_RS00080	COG2314	TM2 domain
I6G39_RS00090	COG1132	(ABC) transporter
I6G39_RS00095	COG2375	cellular response to nickel ion
I6G39_RS00095	COG1132	(ABC) transporter
I6G39_RS00100	COG2223	nitrite transmembrane transporter activity
I6G39_RS00110	COG4585	Histidine kinase
I6G39_RS00120	COG2181	nitrate reductase activity
I6G39_RS00130	COG1140	nitrate reductase beta subunit
I6G39_RS00135	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6G39_RS00165	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6G39_RS00175	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6G39_RS00180	COG0805	protein transport
I6G39_RS00185	COG0672	)-iron permease
I6G39_RS00190	COG2837	iron assimilation
I6G39_RS00195	COG2822	iron ion transport
I6G39_RS00215	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6G39_RS00225	COG3716	PTS system mannose fructose sorbose family IID component
I6G39_RS00230	COG3715	PTS system
I6G39_RS00235	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G39_RS00245	COG3684	Belongs to the aldolase LacD family
I6G39_RS00250	COG1105	Belongs to the carbohydrate kinase PfkB family
I6G39_RS00255	COG2222	sugar isomerase
I6G39_RS00260	COG2188	Transcriptional regulator
I6G39_RS00275	COG1609	Transcriptional regulator
I6G39_RS00290	COG3842	ATPase activity
I6G39_RS00295	COG0395	ABC-type sugar transport system, permease component
I6G39_RS00315	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G39_RS00350	COG1131	(ABC) transporter
I6G39_RS00365	COG1353	crispr-associated protein
I6G39_RS00370	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
I6G39_RS00390	COG1401	restriction endodeoxyribonuclease activity
I6G39_RS00495	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6G39_RS00500	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6G39_RS00515	COG5002	protein histidine kinase activity
I6G39_RS00535	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6G39_RS00540	COG0305	Participates in initiation and elongation during chromosome replication
I6G39_RS00545	COG0359	binds to the 23S rRNA
I6G39_RS00550	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
I6G39_RS00560	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6G39_RS00575	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6G39_RS00580	COG2986	histidine ammonia-lyase
I6G39_RS00585	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6G39_RS00590	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6G39_RS00595	COG0187	DNA topoisomerase II activity
I6G39_RS00600	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6G39_RS00605	COG2501	S4 domain
I6G39_RS00620	COG0592	DNA-directed DNA polymerase activity
I6G39_RS00625	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6G39_RS00635	COG0594	ribonuclease P activity
I6G39_RS00640	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6G39_RS00645	COG0445	tRNA wobble uridine modification
I6G39_RS00655	COG1475	DNA binding
I6G39_RS00670	COG3386	PFAM SMP-30 Gluconolaconase
I6G39_RS00675	COG2314	TM2 domain
I6G39_RS00680	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6G39_RS00685	COG2022	thiamine diphosphate biosynthetic process
I6G39_RS00695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G39_RS00700	COG0352	thiamine-phosphate diphosphorylase activity
I6G39_RS00705	COG1070	Carbohydrate kinase
I6G39_RS00715	COG2205	protein histidine kinase activity
I6G39_RS00720	COG1136	(ABC) transporter
I6G39_RS00730	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6G39_RS00740	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6G39_RS00745	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6G39_RS00745	COG0646	methionine synthase
I6G39_RS00750	COG0626	cystathionine gamma-synthase activity
I6G39_RS00755	COG0626	cystathionine gamma-synthase activity
I6G39_RS00760	COG1475	DNA binding
I6G39_RS00765	COG0668	transmembrane transport
I6G39_RS00770	COG4481	Protein conserved in bacteria
I6G39_RS00775	COG0012	GTP binding
I6G39_RS00785	COG0360	Binds together with S18 to 16S ribosomal RNA
I6G39_RS00795	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6G39_RS00840	COG1518	maintenance of DNA repeat elements
I6G39_RS00850	COG0531	amino acid
I6G39_RS00855	COG1033	growth of symbiont in host cell
I6G39_RS00855	COG2409	Drug exporters of the RND superfamily
I6G39_RS00860	COG0786	glutamate:sodium symporter activity
I6G39_RS00885	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6G39_RS00885	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6G39_RS00895	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6G39_RS00925	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G39_RS00935	COG0778	Nitroreductase
I6G39_RS00960	COG0523	cobalamin synthesis protein
I6G39_RS00970	COG3949	Membrane
I6G39_RS00975	COG2409	Drug exporters of the RND superfamily
I6G39_RS01000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G39_RS01045	COG1054	Belongs to the UPF0176 family
I6G39_RS01060	COG0745	RESPONSE REGULATOR receiver
I6G39_RS01065	COG5002	protein histidine kinase activity
I6G39_RS01070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G39_RS01090	COG3634	alkyl hydroperoxide reductase activity
I6G39_RS01095	COG0450	alkyl hydroperoxide reductase
I6G39_RS01100	COG0753	catalase activity
I6G39_RS01110	COG0778	Nitroreductase
I6G39_RS01120	COG1823	symporter activity
I6G39_RS01125	COG5183	chlorophyll binding
I6G39_RS01140	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6G39_RS01145	COG2233	PERMEase
I6G39_RS01150	COG0517	IMP dehydrogenase activity
I6G39_RS01150	COG0516	GMP reductase activity
I6G39_RS01155	COG0519	Catalyzes the synthesis of GMP from XMP
I6G39_RS01155	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6G39_RS01205	COG0640	Transcriptional regulator
I6G39_RS01260	COG0523	cobalamin synthesis protein
I6G39_RS01270	COG5646	InterPro IPR014922
I6G39_RS01275	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
I6G39_RS01290	COG1114	Component of the transport system for branched-chain amino acids
I6G39_RS01300	COG0733	neurotransmitter:sodium symporter activity
I6G39_RS01335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G39_RS01335	COG1263	PTS System
I6G39_RS01340	COG0366	Alpha amylase catalytic
I6G39_RS01345	COG2188	Transcriptional regulator
I6G39_RS01355	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6G39_RS01360	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6G39_RS01365	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6G39_RS01385	COG1982	Orn Lys Arg decarboxylase major
I6G39_RS01390	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6G39_RS01395	COG3870	Protein conserved in bacteria
I6G39_RS01405	COG1774	PSP1 C-terminal conserved region
I6G39_RS01410	COG4467	Involved in initiation control of chromosome replication
I6G39_RS01415	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6G39_RS01420	COG2827	Endonuclease containing a URI domain
I6G39_RS01425	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6G39_RS01430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G39_RS01430	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G39_RS01435	COG0084	hydrolase, TatD family'
I6G39_RS01440	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I6G39_RS01445	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6G39_RS01450	COG4466	Protein conserved in bacteria
I6G39_RS01455	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6G39_RS01460	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6G39_RS01465	COG0251	oxidation-reduction process
I6G39_RS01470	COG2088	sporulation resulting in formation of a cellular spore
I6G39_RS01475	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6G39_RS01480	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6G39_RS01485	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6G39_RS01490	COG0193	aminoacyl-tRNA hydrolase activity
I6G39_RS01495	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6G39_RS01505	COG3956	TIGRFAM MazG family protein
I6G39_RS01510	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6G39_RS01520	COG1098	S1 RNA binding domain
I6G39_RS01535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6G39_RS01540	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6G39_RS01560	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6G39_RS01565	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6G39_RS01570	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6G39_RS01645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G39_RS01650	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I6G39_RS01655	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I6G39_RS01660	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6G39_RS01670	COG3880	PFAM UvrB UvrC protein
I6G39_RS01675	COG3869	Catalyzes the specific phosphorylation of arginine residues in
I6G39_RS01680	COG0542	response to heat
I6G39_RS01685	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6G39_RS01690	COG4956	integral membrane protein (PIN domain superfamily)
I6G39_RS01695	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6G39_RS01700	COG1045	serine acetyltransferase
I6G39_RS01705	COG0215	cysteine-tRNA ligase activity
I6G39_RS01710	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I6G39_RS01715	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G39_RS01735	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6G39_RS01740	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6G39_RS01745	COG0250	Participates in transcription elongation, termination and antitermination
I6G39_RS01750	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6G39_RS01755	COG0081	regulation of translation
I6G39_RS01760	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6G39_RS01770	COG2813	Specifically methylates the guanine in position
I6G39_RS01775	COG0085	RNA polymerase activity
I6G39_RS01780	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6G39_RS01790	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6G39_RS01800	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6G39_RS01805	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6G39_RS01810	COG1473	amidohydrolase
I6G39_RS01835	COG0039	L-malate dehydrogenase activity
I6G39_RS01840	COG0039	L-malate dehydrogenase activity
I6G39_RS01845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G39_RS01850	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6G39_RS01855	COG0546	phosphoglycolate phosphatase activity
I6G39_RS01865	COG1428	Deoxynucleoside kinase
I6G39_RS01870	COG1428	Deoxynucleoside kinase
I6G39_RS01880	COG0561	phosphatase activity
I6G39_RS01885	COG0431	NADPH-dependent FMN reductase
I6G39_RS01900	COG1469	GTP cyclohydrolase I activity
I6G39_RS01905	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6G39_RS01915	COG0363	glucosamine-6-phosphate deaminase activity
I6G39_RS01920	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I6G39_RS01960	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6G39_RS01970	COG2363	Small membrane protein
I6G39_RS01975	COG0531	amino acid
I6G39_RS01990	COG3253	May function as heme-dependent peroxidase
I6G39_RS01995	COG0280	phosphate acetyltransferase
I6G39_RS02000	COG0095	Lipoate-protein ligase
I6G39_RS02005	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6G39_RS02020	COG4844	belongs to the
I6G39_RS02030	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6G39_RS02040	COG1078	dGTPase activity
I6G39_RS02055	COG0018	arginyl-trna synthetase
I6G39_RS02060	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6G39_RS02065	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6G39_RS02070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G39_RS02075	COG0546	phosphoglycolate phosphatase activity
I6G39_RS02110	COG1802	Transcriptional regulator
I6G39_RS02115	COG1070	Carbohydrate kinase
I6G39_RS02140	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6G39_RS02150	COG1363	Peptidase, m42
I6G39_RS02165	COG2814	Major facilitator Superfamily
I6G39_RS02170	COG2851	Citrate transporter
I6G39_RS02175	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
I6G39_RS02195	COG1174	glycine betaine transport
I6G39_RS02200	COG1960	acyl-CoA dehydrogenase activity
I6G39_RS02210	COG1346	cytolysis
I6G39_RS02215	COG1380	Effector of murein hydrolase LrgA
I6G39_RS02220	COG3279	Response regulator of the LytR AlgR family
I6G39_RS02225	COG3275	phosphorelay sensor kinase activity
I6G39_RS02235	COG4187	Peptidase family M20/M25/M40
I6G39_RS02240	COG0706	membrane insertase activity
I6G39_RS02255	COG2814	Major facilitator Superfamily
I6G39_RS02260	COG1929	Belongs to the glycerate kinase type-1 family
I6G39_RS02270	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6G39_RS02275	COG0588	phosphoglycerate mutase activity
I6G39_RS02285	COG2814	Major facilitator Superfamily
I6G39_RS02305	COG2353	YceI-like domain
I6G39_RS02315	COG2116	formate transmembrane transporter activity
I6G39_RS02320	COG0454	-acetyltransferase
I6G39_RS02325	COG0454	-acetyltransferase
I6G39_RS02365	COG1309	transcriptional regulator
I6G39_RS02385	COG0492	ferredoxin-NADP+ reductase activity
I6G39_RS02395	COG2814	Major facilitator Superfamily
I6G39_RS02405	COG1620	l-lactate permease
I6G39_RS02420	COG5002	protein histidine kinase activity
I6G39_RS02420	COG3850	Histidine kinase
I6G39_RS02430	COG0577	efflux transmembrane transporter activity
I6G39_RS02435	COG1136	(ABC) transporter
I6G39_RS02445	COG4640	response to antibiotic
I6G39_RS02465	COG1304	FMN binding
I6G39_RS02470	COG2094	Belongs to the DNA glycosylase MPG family
I6G39_RS02475	COG4152	abc transporter atp-binding protein
I6G39_RS02480	COG1668	transmembrane transport
I6G39_RS02485	COG2017	converts alpha-aldose to the beta-anomer
I6G39_RS02490	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6G39_RS02495	COG1266	CAAX protease self-immunity
I6G39_RS02500	COG0010	Belongs to the arginase family
I6G39_RS02505	COG0583	DNA-binding transcription factor activity
I6G39_RS02510	COG3314	Sporulation integral membrane protein YlbJ
I6G39_RS02515	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6G39_RS02520	COG1228	amidohydrolase
I6G39_RS02525	COG1473	amidohydrolase
I6G39_RS02530	COG1028	Short-chain dehydrogenase reductase Sdr
I6G39_RS02550	COG1737	Transcriptional regulator
I6G39_RS02555	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G39_RS02555	COG1263	PTS System
I6G39_RS02565	COG0385	Bile acid
I6G39_RS02570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G39_RS02590	COG1113	amino acid transport
I6G39_RS02605	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6G39_RS02620	COG0483	inositol monophosphate 1-phosphatase activity
I6G39_RS02625	COG1316	TRANSCRIPTIONal
I6G39_RS02630	COG3383	formate dehydrogenase (NAD+) activity
I6G39_RS02655	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6G39_RS02660	COG2076	Multidrug Resistance protein
I6G39_RS02665	COG2076	Multidrug Resistance protein
I6G39_RS02680	COG1757	Na H antiporter
I6G39_RS02690	COG3942	CHAP domain
I6G39_RS02705	COG0765	amino acid transport
I6G39_RS02710	COG0765	amino acid transport
I6G39_RS02715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G39_RS02720	COG1126	abc transporter atp-binding protein
I6G39_RS02725	COG1960	acyl-CoA dehydrogenase activity
I6G39_RS02735	COG1268	BioY protein
I6G39_RS02750	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6G39_RS02755	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6G39_RS02760	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I6G39_RS02765	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6G39_RS02770	COG4149	molybdate abc transporter
I6G39_RS02775	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6G39_RS02780	COG1510	regulation of RNA biosynthetic process
I6G39_RS02785	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6G39_RS02795	COG0315	cyclic pyranopterin monophosphate synthase activity
I6G39_RS02805	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6G39_RS02820	COG0746	molybdenum cofactor guanylyltransferase activity
I6G39_RS02825	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6G39_RS02840	COG2348	transferase activity, transferring amino-acyl groups
I6G39_RS02845	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G39_RS02870	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6G39_RS02870	COG0551	DNA topoisomerase type I activity
I6G39_RS02875	COG2252	PERMEase
I6G39_RS02885	COG0051	transcription antitermination factor activity, RNA binding
I6G39_RS02890	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6G39_RS02895	COG0088	Forms part of the polypeptide exit tunnel
I6G39_RS02900	COG0089	rRNA binding
I6G39_RS02905	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6G39_RS02910	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6G39_RS02915	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6G39_RS02920	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6G39_RS02925	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6G39_RS02935	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6G39_RS02940	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6G39_RS02945	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6G39_RS02950	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6G39_RS02955	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6G39_RS02960	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6G39_RS02965	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6G39_RS02970	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6G39_RS02975	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6G39_RS02980	COG1841	ribosomal large subunit assembly
I6G39_RS02990	COG0201	protein transport
I6G39_RS03005	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6G39_RS03010	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6G39_RS03025	COG0203	ribosomal protein L17
I6G39_RS03030	COG1122	ATPase activity
I6G39_RS03035	COG1122	ATPase activity
I6G39_RS03045	COG0101	tRNA pseudouridine synthase activity
I6G39_RS03050	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6G39_RS03055	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6G39_RS03065	COG2130	NADP-dependent
I6G39_RS03070	COG0604	alcohol dehydrogenase
I6G39_RS03075	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6G39_RS03090	COG1302	Protein conserved in bacteria
I6G39_RS03095	COG4264	IucA IucC family
I6G39_RS03100	COG2814	Major facilitator Superfamily
I6G39_RS03105	COG4264	IucA IucC family
I6G39_RS03110	COG3457	Alanine racemase
I6G39_RS03115	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I6G39_RS03120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G39_RS03125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G39_RS03130	COG3314	Sporulation integral membrane protein YlbJ
I6G39_RS03140	COG1988	membrane-bound metal-dependent
I6G39_RS03145	COG4284	Utp--glucose-1-phosphate uridylyltransferase
I6G39_RS03150	COG1272	protein, Hemolysin III
I6G39_RS03165	COG2814	Major facilitator Superfamily
I6G39_RS03170	COG0489	protein tyrosine kinase activity
I6G39_RS03225	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I6G39_RS03235	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6G39_RS03245	COG1119	ATPase activity
I6G39_RS03250	COG0561	phosphatase activity
I6G39_RS03270	COG0640	Transcriptional regulator
I6G39_RS03275	COG0702	epimerase
I6G39_RS03280	COG1482	cell wall glycoprotein biosynthetic process
I6G39_RS03290	COG2855	membrane
I6G39_RS03305	COG0783	Belongs to the Dps family
I6G39_RS03310	COG0813	purine-nucleoside phosphorylase activity
I6G39_RS03315	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6G39_RS03320	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I6G39_RS03325	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6G39_RS03355	COG5146	pantothenate kinase activity
I6G39_RS03360	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G39_RS03365	COG3343	RNA polymerase activity
I6G39_RS03370	COG0504	CTP synthase activity
I6G39_RS03375	COG0191	fructose-bisphosphate aldolase activity
I6G39_RS03380	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6G39_RS03390	COG1012	belongs to the aldehyde dehydrogenase family
I6G39_RS03395	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6G39_RS03400	COG0254	rRNA binding
I6G39_RS03405	COG1435	thymidine kinase activity
I6G39_RS03415	COG2890	protein-(glutamine-N5) methyltransferase activity
I6G39_RS03420	COG0009	L-threonylcarbamoyladenylate synthase
I6G39_RS03425	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6G39_RS03430	COG4475	Protein of unknown function (DUF436)
I6G39_RS03435	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6G39_RS03440	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6G39_RS03445	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6G39_RS03455	COG0356	it plays a direct role in the translocation of protons across the membrane
I6G39_RS03460	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6G39_RS03465	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6G39_RS03470	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6G39_RS03480	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6G39_RS03485	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6G39_RS03490	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6G39_RS03495	COG4836	Membrane
I6G39_RS03500	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6G39_RS03515	COG0629	single-stranded DNA binding
I6G39_RS03520	COG1388	LysM domain
I6G39_RS03525	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6G39_RS03535	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I6G39_RS03540	COG0352	thiamine-phosphate diphosphorylase activity
I6G39_RS03545	COG0706	membrane insertase activity
I6G39_RS03565	COG1937	Protein conserved in bacteria
I6G39_RS03580	COG0772	Belongs to the SEDS family
I6G39_RS03585	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6G39_RS03590	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6G39_RS03595	COG0513	Belongs to the DEAD box helicase family
I6G39_RS03600	COG3402	PFAM membrane-flanked domain
I6G39_RS03610	COG3402	PFAM membrane-flanked domain
I6G39_RS03620	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6G39_RS03630	COG2337	Toxic component of a toxin-antitoxin (TA) module
I6G39_RS03635	COG2208	phosphoserine phosphatase activity
I6G39_RS03650	COG1191	sigma factor activity
I6G39_RS03655	COG2183	response to ionizing radiation
I6G39_RS03700	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6G39_RS03705	COG0473	3-isopropylmalate dehydrogenase activity
I6G39_RS03710	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6G39_RS03715	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6G39_RS03725	COG0028	Belongs to the TPP enzyme family
I6G39_RS03730	COG0129	dihydroxy-acid dehydratase activity
I6G39_RS03735	COG0802	atpase or kinase
I6G39_RS03740	COG1214	PFAM Peptidase M22, glycoprotease
I6G39_RS03745	COG0456	acetyltransferase
I6G39_RS03750	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6G39_RS03760	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6G39_RS03765	COG0488	(ABC) transporter
I6G39_RS03770	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I6G39_RS03775	COG1609	Transcriptional regulator
I6G39_RS03780	COG1621	beta-fructofuranosidase activity
I6G39_RS03785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G39_RS03805	COG4512	PFAM Accessory gene regulator B
I6G39_RS03835	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6G39_RS03840	COG0459	protein refolding
I6G39_RS03850	COG0577	efflux transmembrane transporter activity
I6G39_RS03850	COG1136	(ABC) transporter
I6G39_RS03865	COG1725	Transcriptional regulator
I6G39_RS03870	COG1131	(ABC) transporter
I6G39_RS03880	COG1131	(ABC) transporter
I6G39_RS03920	COG2706	6-phosphogluconolactonase activity
I6G39_RS03930	COG1227	inorganic diphosphatase activity
I6G39_RS03935	COG1335	isochorismatase
I6G39_RS03940	COG5434	Belongs to the glycosyl hydrolase 28 family
I6G39_RS03945	COG0471	metal ion transport
I6G39_RS03950	COG0077	Prephenate dehydratase
I6G39_RS03960	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6G39_RS03965	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6G39_RS03970	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
I6G39_RS03980	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6G39_RS03985	COG4496	protein, YerC YecD
I6G39_RS03990	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
I6G39_RS03995	COG0210	DNA helicase
I6G39_RS04000	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6G39_RS04005	COG4851	CamS sex pheromone cAM373 precursor
I6G39_RS04010	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G39_RS04015	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6G39_RS04020	COG0154	amidase activity
I6G39_RS04025	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6G39_RS04030	COG1597	lipid kinase activity
I6G39_RS04035	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6G39_RS04045	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6G39_RS04055	COG1528	Iron-storage protein
I6G39_RS04070	COG4129	membrane
I6G39_RS04075	COG0024	Methionine aminopeptidase
I6G39_RS04095	COG2197	response regulator
I6G39_RS04100	COG0288	reversible hydration of carbon dioxide
I6G39_RS04105	COG1295	ribonuclease BN
I6G39_RS04120	COG4840	Belongs to the UPF0435 family
I6G39_RS04125	COG2309	aminopeptidase activity
I6G39_RS04130	COG1607	acyl-coa hydrolase
I6G39_RS04135	COG0535	radical SAM domain protein
I6G39_RS04145	COG0693	protein deglycase activity
I6G39_RS04150	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G39_RS04165	COG1134	teichoic acid transport
I6G39_RS04175	COG1988	membrane-bound metal-dependent
I6G39_RS04185	COG3557	Belongs to the UPF0374 family
I6G39_RS04195	COG4129	membrane
I6G39_RS04200	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6G39_RS04205	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6G39_RS04210	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6G39_RS04215	COG0735	belongs to the Fur family
I6G39_RS04375	COG0740	serine-type endopeptidase activity
I6G39_RS04455	COG4195	phage-related replication protein
I6G39_RS04475	COG1388	LysM domain
I6G39_RS04475	COG5632	N-Acetylmuramoyl-L-alanine amidase
I6G39_RS04505	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6G39_RS04515	COG0363	glucosamine-6-phosphate deaminase activity
I6G39_RS04530	COG0114	fumarate hydratase activity
I6G39_RS04535	COG0564	pseudouridine synthase activity
I6G39_RS04540	COG1301	dicarboxylic acid transport
I6G39_RS04555	COG0740	serine-type endopeptidase activity
I6G39_RS04565	COG4399	Belongs to the UPF0754 family
I6G39_RS04575	COG0420	3'-5' exonuclease activity
I6G39_RS04585	COG3481	metal-dependent phosphohydrolase, HD sub domain
I6G39_RS04590	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G39_RS04605	COG0537	adenosine 5'-monophosphoramidase activity
I6G39_RS04610	COG1131	(ABC) transporter
I6G39_RS04615	COG4473	ABC transporter
I6G39_RS04625	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6G39_RS04630	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6G39_RS04635	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I6G39_RS04695	COG1525	nuclease
I6G39_RS04725	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6G39_RS04730	COG0494	nUDIX hydrolase
I6G39_RS04735	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I6G39_RS04740	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6G39_RS04750	COG0656	L-ascorbic acid biosynthetic process
I6G39_RS04755	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6G39_RS04760	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6G39_RS04770	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6G39_RS04805	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6G39_RS04805	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6G39_RS04810	COG0307	riboflavin synthase, alpha
I6G39_RS04815	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6G39_RS04815	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6G39_RS04820	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6G39_RS04825	COG0506	proline dehydrogenase activity
I6G39_RS04830	COG2267	carboxylic ester hydrolase activity
I6G39_RS04835	COG0039	L-malate dehydrogenase activity
I6G39_RS04845	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6G39_RS04850	COG1242	4 iron, 4 sulfur cluster binding
I6G39_RS04855	COG2814	Major facilitator Superfamily
I6G39_RS04875	COG2081	HI0933 family
I6G39_RS04880	COG2244	polysaccharide biosynthetic process
I6G39_RS04885	COG1187	pseudouridine synthase activity
I6G39_RS04895	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6G39_RS04905	COG0510	thiamine kinase activity
I6G39_RS04910	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6G39_RS04915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G39_RS04920	COG5584	Small secreted protein
I6G39_RS04925	COG1363	Peptidase, m42
I6G39_RS04930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G39_RS04935	COG4848	Belongs to the UPF0354 family
I6G39_RS04940	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G39_RS04945	COG1674	ftsk spoiiie
I6G39_RS04950	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6G39_RS04955	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
I6G39_RS04965	COG1605	Chorismate mutase
I6G39_RS04965	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I6G39_RS04970	COG1609	Transcriptional regulator
I6G39_RS04975	COG0123	including yeast histone deacetylase and acetoin utilization protein
I6G39_RS04980	COG0454	-acetyltransferase
I6G39_RS04985	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6G39_RS04995	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6G39_RS05005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G39_RS05010	COG0204	Acyl-transferase
I6G39_RS05015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G39_RS05015	COG1263	PTS System
I6G39_RS05025	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6G39_RS05030	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6G39_RS05035	COG1764	response to oxidative stress
I6G39_RS05040	COG0584	glycerophosphoryl diester phosphodiesterase
I6G39_RS05045	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6G39_RS05050	COG1956	GAF domain-containing protein
I6G39_RS05055	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
I6G39_RS05060	COG1104	cysteine desulfurase activity
I6G39_RS05065	COG0301	tRNA thio-modification
I6G39_RS05070	COG0730	response to heat
I6G39_RS05075	COG0616	signal peptide processing
I6G39_RS05080	COG1714	RDD family
I6G39_RS05085	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6G39_RS05090	COG0827	DNA restriction-modification system
I6G39_RS05095	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6G39_RS05100	COG0589	response to stress
I6G39_RS05105	COG0686	Belongs to the AlaDH PNT family
I6G39_RS05110	COG0006	proline dipeptidase activity
I6G39_RS05115	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6G39_RS05125	COG4109	DRTGG domain
I6G39_RS05130	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6G39_RS05135	COG0587	DNA-directed DNA polymerase activity
I6G39_RS05140	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6G39_RS05145	COG0825	malonyl-CoA metabolic process
I6G39_RS05150	COG0205	6-phosphofructokinase activity
I6G39_RS05155	COG0469	pyruvate kinase activity
I6G39_RS05160	COG1113	amino acid transport
I6G39_RS05165	COG0372	Belongs to the citrate synthase family
I6G39_RS05170	COG0538	isocitrate dehydrogenase activity
I6G39_RS05175	COG0745	RESPONSE REGULATOR receiver
I6G39_RS05180	COG5002	protein histidine kinase activity
I6G39_RS05185	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G39_RS05185	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G39_RS05190	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6G39_RS05195	COG0237	dephospho-CoA kinase activity
I6G39_RS05200	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6G39_RS05205	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6G39_RS05210	COG3611	Membrane attachment protein
I6G39_RS05215	COG1484	DNA-dependent DNA replication
I6G39_RS05220	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6G39_RS05225	COG0833	amino acid
I6G39_RS05230	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6G39_RS05235	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6G39_RS05240	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6G39_RS05255	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6G39_RS05260	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6G39_RS05265	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6G39_RS05270	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6G39_RS05275	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6G39_RS05280	COG0181	hydroxymethylbilane synthase activity
I6G39_RS05290	COG0113	porphobilinogen synthase activity
I6G39_RS05295	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6G39_RS05305	COG2818	Glycosylase
I6G39_RS05310	COG0525	valine-tRNA ligase activity
I6G39_RS05315	COG0285	dihydrofolate synthase activity
I6G39_RS05350	COG1792	Involved in formation and maintenance of cell shape
I6G39_RS05360	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6G39_RS05365	COG2868	ribosomal protein
I6G39_RS05370	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6G39_RS05380	COG4492	Belongs to the UPF0735 family
I6G39_RS05385	COG0632	four-way junction helicase activity
I6G39_RS05390	COG2255	four-way junction helicase activity
I6G39_RS05395	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6G39_RS05400	COG0343	queuine tRNA-ribosyltransferase activity
I6G39_RS05405	COG1862	Preprotein translocase
I6G39_RS05410	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6G39_RS05410	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6G39_RS05415	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I6G39_RS05415	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6G39_RS05430	COG1490	D-aminoacyl-tRNA deacylase activity
I6G39_RS05435	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6G39_RS05445	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6G39_RS05455	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6G39_RS05460	COG1959	2 iron, 2 sulfur cluster binding
I6G39_RS05465	COG3237	CsbD-like
I6G39_RS05470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G39_RS05475	COG1104	cysteine desulfurase activity
I6G39_RS05480	COG0482	sulfurtransferase activity
I6G39_RS05490	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6G39_RS05495	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6G39_RS05500	COG4472	Bacterial protein of unknown function (DUF965)
I6G39_RS05505	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6G39_RS05510	COG3906	Belongs to the UPF0473 family
I6G39_RS05515	COG4122	O-methyltransferase activity
I6G39_RS05520	COG0826	peptidase U32
I6G39_RS05525	COG0826	peptidase U32
I6G39_RS05530	COG0572	uridine kinase
I6G39_RS05535	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6G39_RS05540	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6G39_RS05545	COG1984	allophanate hydrolase subunit 2
I6G39_RS05550	COG0511	ligase activity, forming carbon-carbon bonds
I6G39_RS05555	COG0439	Biotin carboxylase
I6G39_RS05560	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6G39_RS05570	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6G39_RS05575	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I6G39_RS05580	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6G39_RS05585	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6G39_RS05590	COG1534	Rna-binding protein
I6G39_RS05595	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6G39_RS05600	COG1713	HD superfamily hydrolase involved in NAD metabolism
I6G39_RS05605	COG0799	negative regulation of ribosome biogenesis
I6G39_RS05610	COG2226	methyltransferase
I6G39_RS05615	COG1596	polysaccharide export
I6G39_RS05615	COG1555	photosystem II stabilization
I6G39_RS05620	COG2131	deaminase
I6G39_RS05630	COG0658	competence protein
I6G39_RS05630	COG2333	competence protein COMEC
I6G39_RS05635	COG1466	dna polymerase III delta subunit
I6G39_RS05640	COG0268	Binds directly to 16S ribosomal RNA
I6G39_RS05645	COG0481	GTPase activity
I6G39_RS05650	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6G39_RS05655	COG1420	regulation of RNA biosynthetic process
I6G39_RS05660	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6G39_RS05665	COG0443	Heat shock 70 kDa protein
I6G39_RS05670	COG0484	heat shock protein binding
I6G39_RS05675	COG2264	protein methyltransferase activity
I6G39_RS05680	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6G39_RS05695	COG4864	UPF0365 protein
I6G39_RS05705	COG1702	phosphate starvation-inducible protein PhoH
I6G39_RS05715	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6G39_RS05725	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6G39_RS05730	COG1381	Involved in DNA repair and RecF pathway recombination
I6G39_RS05735	COG0423	glycine-tRNA ligase activity
I6G39_RS05740	COG0517	IMP dehydrogenase activity
I6G39_RS05745	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6G39_RS05750	COG0358	DNA primase activity
I6G39_RS05755	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6G39_RS05760	COG2384	SAM-dependent methyltransferase
I6G39_RS05770	COG0513	Belongs to the DEAD box helicase family
I6G39_RS05775	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I6G39_RS05780	COG1121	(ABC) transporter
I6G39_RS05785	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6G39_RS05790	COG0735	belongs to the Fur family
I6G39_RS05795	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6G39_RS05800	COG0768	penicillin binding
I6G39_RS05805	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6G39_RS05810	COG0457	Tetratricopeptide repeat
I6G39_RS05810	COG0705	Rhomboid family
I6G39_RS05815	COG4483	Protein conserved in bacteria
I6G39_RS05820	COG1940	carbohydrate kinase activity
I6G39_RS05825	COG0011	TIGRFAM Protein of
I6G39_RS05830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G39_RS05845	COG4537	Required for transformation and DNA binding
I6G39_RS05865	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6G39_RS05870	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6G39_RS05875	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6G39_RS05880	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6G39_RS05885	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G39_RS05890	COG0095	Lipoate-protein ligase
I6G39_RS05905	COG0006	proline dipeptidase activity
I6G39_RS05910	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6G39_RS05915	COG0511	ligase activity, forming carbon-carbon bonds
I6G39_RS05920	COG0439	Biotin carboxylase
I6G39_RS05925	COG1302	Protein conserved in bacteria
I6G39_RS05930	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6G39_RS05950	COG1438	arginine binding
I6G39_RS05955	COG0497	DNA recombination
I6G39_RS05960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G39_RS05965	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6G39_RS05970	COG0022	dehydrogenase e1 component
I6G39_RS05975	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G39_RS05985	COG4129	membrane
I6G39_RS05995	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6G39_RS06005	COG0366	Alpha amylase catalytic
I6G39_RS06015	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6G39_RS06020	COG1234	tRNA 3'-trailer cleavage
I6G39_RS06025	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6G39_RS06035	COG0667	Aldo Keto reductase
I6G39_RS06040	COG0494	nUDIX hydrolase
I6G39_RS06045	COG0735	belongs to the Fur family
I6G39_RS06050	COG4974	Belongs to the 'phage' integrase family
I6G39_RS06060	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6G39_RS06065	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6G39_RS06070	COG1187	pseudouridine synthase activity
I6G39_RS06075	COG0745	RESPONSE REGULATOR receiver
I6G39_RS06090	COG1141	Ferredoxin
I6G39_RS06100	COG0514	ATP-dependent DNA helicase (RecQ)
I6G39_RS06110	COG0492	ferredoxin-NADP+ reductase activity
I6G39_RS06120	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6G39_RS06125	COG0539	negative regulation of cytoplasmic translation
I6G39_RS06155	COG1160	GTP binding
I6G39_RS06160	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6G39_RS06175	COG2226	methyltransferase
I6G39_RS06180	COG0142	geranyltranstransferase activity
I6G39_RS06185	COG0105	UTP biosynthetic process
I6G39_RS06210	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6G39_RS06220	COG0457	Tetratricopeptide repeat
I6G39_RS06230	COG4347	Protein of unknown function (DUF1405)
I6G39_RS06235	COG2738	Putative neutral zinc metallopeptidase
I6G39_RS06240	COG1694	Mazg nucleotide pyrophosphohydrolase
I6G39_RS06245	COG0438	transferase activity, transferring glycosyl groups
I6G39_RS06250	COG0617	tRNA 3'-terminal CCA addition
I6G39_RS06260	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6G39_RS06260	COG1199	ATP-dependent helicase activity
I6G39_RS06265	COG0017	Asparaginyl-tRNA synthetase
I6G39_RS06270	COG3935	DnaD domain protein
I6G39_RS06275	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6G39_RS06285	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G39_RS06285	COG4499	WXG100 protein secretion system (Wss), protein YukC
I6G39_RS06290	COG3331	DNA recombination
I6G39_RS06300	COG4474	Belongs to the UPF0398 family
I6G39_RS06305	COG3599	regulation of cell shape
I6G39_RS06315	COG0116	Belongs to the methyltransferase superfamily
I6G39_RS06320	COG2962	Rard protein
I6G39_RS06330	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I6G39_RS06335	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G39_RS06350	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6G39_RS06360	COG1413	lyase activity
I6G39_RS06390	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6G39_RS06400	COG4479	Belongs to the UPF0346 family
I6G39_RS06405	COG0793	Belongs to the peptidase S41A family
I6G39_RS06415	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6G39_RS06420	COG0671	phosphoesterase, PA-phosphatase related
I6G39_RS06425	COG0745	RESPONSE REGULATOR receiver
I6G39_RS06430	COG5002	protein histidine kinase activity
I6G39_RS06440	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G39_RS06480	COG0714	Associated with various cellular activities
I6G39_RS06485	COG4548	von Willebrand factor, type A
I6G39_RS06490	COG1114	Component of the transport system for branched-chain amino acids
I6G39_RS06495	COG3853	Toxic anion resistance protein (TelA)
I6G39_RS06505	COG1254	Belongs to the acylphosphatase family
I6G39_RS06515	COG1278	Cold shock
I6G39_RS06540	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6G39_RS06545	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6G39_RS06550	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6G39_RS06560	COG0488	(ABC) transporter
I6G39_RS06565	COG2996	Protein conserved in bacteria
I6G39_RS06570	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6G39_RS06575	COG0573	inorganic phosphate transmembrane transporter activity
I6G39_RS06580	COG0573	inorganic phosphate transmembrane transporter activity
I6G39_RS06585	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6G39_RS06590	COG0704	Plays a role in the regulation of phosphate uptake
I6G39_RS06595	COG1164	Oligoendopeptidase f
I6G39_RS06610	COG2348	transferase activity, transferring amino-acyl groups
I6G39_RS06615	COG1363	Peptidase, m42
I6G39_RS06620	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6G39_RS06625	COG1942	4-Oxalocrotonate Tautomerase
I6G39_RS06640	COG0392	lysyltransferase activity
I6G39_RS06640	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I6G39_RS06645	COG0628	permease
I6G39_RS06650	COG3711	transcriptional antiterminator
I6G39_RS06655	COG1115	amino acid carrier protein
I6G39_RS06660	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6G39_RS06670	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6G39_RS06675	COG4841	protein insertion into membrane
I6G39_RS06680	COG0824	Thioesterase
I6G39_RS06685	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6G39_RS06690	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6G39_RS06695	COG1970	mechanosensitive ion channel activity
I6G39_RS06700	COG0419	ATPase involved in DNA repair
I6G39_RS06705	COG0420	3'-5' exonuclease activity
I6G39_RS06710	COG4846	Membrane protein involved in cytochrome C biogenesis
I6G39_RS06715	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6G39_RS06735	COG2235	arginine
I6G39_RS06740	COG1438	arginine binding
I6G39_RS06755	COG3763	UPF0154 protein
I6G39_RS06775	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6G39_RS06785	COG0516	GMP reductase activity
I6G39_RS06790	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6G39_RS06795	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6G39_RS06800	COG0833	amino acid
I6G39_RS06815	COG0083	homoserine kinase activity
I6G39_RS06820	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6G39_RS06825	COG0460	homoserine dehydrogenase
I6G39_RS06830	COG0527	aspartate kinase activity
I6G39_RS06865	COG0789	Transcriptional regulator
I6G39_RS06870	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
I6G39_RS06875	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6G39_RS06880	COG0386	Belongs to the glutathione peroxidase family
I6G39_RS06885	COG1923	regulation of RNA biosynthetic process
I6G39_RS06890	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6G39_RS06900	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6G39_RS06905	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6G39_RS06910	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6G39_RS06915	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I6G39_RS06920	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6G39_RS06925	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6G39_RS06935	COG4550	Control of competence regulator ComK, YlbF/YmcA
I6G39_RS06945	COG4195	phage-related replication protein
I6G39_RS06955	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6G39_RS06960	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6G39_RS06960	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6G39_RS06965	COG1692	metallophosphoesterase
I6G39_RS06975	COG1418	mRNA catabolic process
I6G39_RS06980	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6G39_RS06985	COG1058	Belongs to the CinA family
I6G39_RS06985	COG1546	Belongs to the CinA family
I6G39_RS07010	COG0612	Peptidase, M16
I6G39_RS07020	COG2188	Transcriptional regulator
I6G39_RS07030	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6G39_RS07035	COG1185	polyribonucleotide nucleotidyltransferase activity
I6G39_RS07040	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6G39_RS07045	COG0196	riboflavin kinase activity
I6G39_RS07050	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6G39_RS07055	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6G39_RS07060	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6G39_RS07065	COG1358	cellular component organization or biogenesis
I6G39_RS07070	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I6G39_RS07075	COG0195	Participates in both transcription termination and antitermination
I6G39_RS07080	COG0779	Required for maturation of 30S ribosomal subunits
I6G39_RS07085	COG2176	DNA-directed DNA polymerase activity
I6G39_RS07090	COG0442	prolyl-tRNA aminoacylation
I6G39_RS07100	COG4589	Belongs to the CDS family
I6G39_RS07105	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6G39_RS07110	COG0233	cytoplasmic translational termination
I6G39_RS07115	COG0528	UMP kinase activity
I6G39_RS07120	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6G39_RS07125	COG0052	Belongs to the universal ribosomal protein uS2 family
I6G39_RS07130	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I6G39_RS07135	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I6G39_RS07140	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I6G39_RS07145	COG4974	Belongs to the 'phage' integrase family
I6G39_RS07150	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
I6G39_RS07155	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6G39_RS07160	COG0758	DNA mediated transformation
I6G39_RS07170	COG0045	succinate-CoA ligase (ADP-forming) activity
I6G39_RS07175	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6G39_RS07185	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I6G39_RS07190	COG4485	Bacterial membrane protein, YfhO
I6G39_RS07200	COG0335	large ribosomal subunit rRNA binding
I6G39_RS07205	COG0336	Belongs to the RNA methyltransferase TrmD family
I6G39_RS07210	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6G39_RS07215	COG0228	four-way junction DNA binding
I6G39_RS07220	COG4690	dipeptidase activity
I6G39_RS07230	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6G39_RS07235	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
I6G39_RS07240	COG0552	protein localization to endoplasmic reticulum
I6G39_RS07245	COG1196	nuclear chromosome segregation
I6G39_RS07250	COG0571	ribonuclease III activity
I6G39_RS07255	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G39_RS07270	COG0416	fatty acid biosynthetic process
I6G39_RS07275	COG1349	DNA-binding transcription factor activity
I6G39_RS07285	COG1760	l-serine dehydratase
I6G39_RS07290	COG1760	l-serine dehydratase
I6G39_RS07295	COG1461	Dihydroxyacetone kinase
I6G39_RS07300	COG1302	Protein conserved in bacteria
I6G39_RS07305	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6G39_RS07310	COG1564	THIamine pyrophosphokinase
I6G39_RS07315	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6G39_RS07320	COG1162	GTPase activity
I6G39_RS07335	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6G39_RS07340	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6G39_RS07340	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6G39_RS07345	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6G39_RS07350	COG0242	peptide deformylase activity
I6G39_RS07355	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6G39_RS07360	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6G39_RS07370	COG0194	GDP metabolic process
I6G39_RS07375	COG1293	RNA-binding protein homologous to eukaryotic snRNP
I6G39_RS07390	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6G39_RS07400	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6G39_RS07405	COG0505	Belongs to the CarA family
I6G39_RS07415	COG0540	Belongs to the ATCase OTCase family
I6G39_RS07420	COG2233	PERMEase
I6G39_RS07425	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I6G39_RS07430	COG0564	pseudouridine synthase activity
I6G39_RS07435	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6G39_RS07440	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6G39_RS07445	COG3599	regulation of cell shape
I6G39_RS07455	COG0762	integral membrane protein
I6G39_RS07460	COG1799	cell septum assembly
I6G39_RS07465	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6G39_RS07470	COG1496	oxidoreductase activity
I6G39_RS07475	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6G39_RS07480	COG0849	cell division
I6G39_RS07485	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6G39_RS07490	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6G39_RS07495	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6G39_RS07500	COG0768	penicillin binding
I6G39_RS07505	COG4839	cell division protein FtsL
I6G39_RS07510	COG0275	rRNA processing
I6G39_RS07520	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
I6G39_RS07525	COG1011	Hydrolase
I6G39_RS07560	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6G39_RS07565	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6G39_RS07570	COG1053	succinate dehydrogenase
I6G39_RS07575	COG2009	succinate dehydrogenase
I6G39_RS07580	COG0322	excinuclease ABC activity
I6G39_RS07585	COG3118	belongs to the thioredoxin family
I6G39_RS07590	COG1193	negative regulation of DNA recombination
I6G39_RS07595	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6G39_RS07595	COG1796	DNA polymerase
I6G39_RS07605	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
I6G39_RS07610	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6G39_RS07615	COG0072	phenylalanine-tRNA ligase activity
I6G39_RS07620	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6G39_RS07625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G39_RS07630	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6G39_RS07640	COG1323	Belongs to the UPF0348 family
I6G39_RS07645	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6G39_RS07650	COG0742	ribosomal rna small subunit methyltransferase
I6G39_RS07665	COG0584	glycerophosphoryl diester phosphodiesterase
I6G39_RS07670	COG3679	Belongs to the UPF0342 family
I6G39_RS07685	COG0109	protoheme IX farnesyltransferase activity
I6G39_RS07690	COG1612	heme a metabolic process
I6G39_RS07705	COG0772	Belongs to the SEDS family
I6G39_RS07710	COG4838	Belongs to the UPF0358 family
I6G39_RS07715	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6G39_RS07720	COG4896	Protein conserved in bacteria
I6G39_RS07725	COG1217	gtp-binding protein TYPA
I6G39_RS07735	COG0483	inositol monophosphate 1-phosphatase activity
I6G39_RS07740	COG4493	Belongs to the UPF0637 family
I6G39_RS07755	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6G39_RS07760	COG1177	transmembrane transport
I6G39_RS07765	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6G39_RS07770	COG3842	ATPase activity
I6G39_RS07780	COG4476	Belongs to the UPF0223 family
I6G39_RS07810	COG0242	peptide deformylase activity
I6G39_RS07820	COG5503	Protein of unknown function (DUF1447)
I6G39_RS07825	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6G39_RS07830	COG0569	domain protein
I6G39_RS07840	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6G39_RS07845	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G39_RS07855	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6G39_RS07875	COG1122	ATPase activity
I6G39_RS07880	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I6G39_RS07890	COG0138	bifunctional purine biosynthesis protein purh
I6G39_RS07895	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6G39_RS07900	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6G39_RS07910	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6G39_RS07925	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6G39_RS07930	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6G39_RS07935	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6G39_RS07940	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6G39_RS07950	COG1017	nitric oxide dioxygenase activity
I6G39_RS07950	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6G39_RS07960	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6G39_RS07970	COG1845	cytochrome c oxidase, subunit III
I6G39_RS07975	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6G39_RS07980	COG1349	DNA-binding transcription factor activity
I6G39_RS07990	COG0698	ribose 5-phosphate isomerase
I6G39_RS08015	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6G39_RS08015	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6G39_RS08020	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6G39_RS08030	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6G39_RS08035	COG1316	TRANSCRIPTIONal
I6G39_RS08060	COG3594	Acyltransferase
I6G39_RS08065	COG0436	Aminotransferase
I6G39_RS08075	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6G39_RS08080	COG2267	carboxylic ester hydrolase activity
I6G39_RS08085	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I6G39_RS08090	COG1169	isochorismate synthase
I6G39_RS08095	COG1575	Belongs to the MenA family. Type 1 subfamily
I6G39_RS08120	COG4873	Protein conserved in bacteria
I6G39_RS08135	COG4903	ComK protein
I6G39_RS08155	COG0737	Belongs to the 5'-nucleotidase family
I6G39_RS08160	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6G39_RS08165	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G39_RS08170	COG0861	Integral membrane protein TerC family
I6G39_RS08175	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6G39_RS08190	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6G39_RS08195	COG2814	Major facilitator Superfamily
I6G39_RS08200	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I6G39_RS08210	COG1115	amino acid carrier protein
I6G39_RS08215	COG0628	permease
I6G39_RS08220	COG1418	mRNA catabolic process
I6G39_RS08230	COG0569	domain protein
I6G39_RS08230	COG0475	glutathione-regulated potassium exporter activity
I6G39_RS08235	COG2239	Acts as a magnesium transporter
I6G39_RS08240	COG0564	pseudouridine synthase activity
I6G39_RS08245	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6G39_RS08250	COG2357	RelA SpoT domain protein
I6G39_RS08265	COG2346	COG2346, Truncated hemoglobins
I6G39_RS08270	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6G39_RS08275	COG1164	Oligoendopeptidase f
I6G39_RS08285	COG4862	establishment of competence for transformation
I6G39_RS08290	COG1393	Belongs to the ArsC family
I6G39_RS08305	COG4608	Belongs to the ABC transporter superfamily
I6G39_RS08310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G39_RS08315	COG0601	transmembrane transport
I6G39_RS08325	COG4166	transmembrane transport
I6G39_RS08330	COG4608	Belongs to the ABC transporter superfamily
I6G39_RS08335	COG0444	Belongs to the ABC transporter superfamily
I6G39_RS08340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G39_RS08345	COG0601	transmembrane transport
I6G39_RS08355	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6G39_RS08365	COG0542	response to heat
I6G39_RS08380	COG0561	phosphatase activity
I6G39_RS08385	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6G39_RS08395	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6G39_RS08400	COG1074	ATP-dependent DNA helicase activity
I6G39_RS08405	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
I6G39_RS08425	COG0166	Belongs to the GPI family
I6G39_RS08430	COG0584	glycerophosphoryl diester phosphodiesterase
I6G39_RS08440	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6G39_RS08445	COG1012	belongs to the aldehyde dehydrogenase family
I6G39_RS08450	COG1902	pentaerythritol trinitrate reductase activity
I6G39_RS08455	COG1098	S1 RNA binding domain
I6G39_RS08465	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6G39_RS08475	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6G39_RS08475	COG2111	Na H antiporter
I6G39_RS08480	COG2111	Na H antiporter
I6G39_RS08485	COG1006	Multisubunit Na H antiporter MnhC subunit
I6G39_RS08490	COG0651	ATP synthesis coupled electron transport
I6G39_RS08495	COG1863	multisubunit Na H antiporter MnhE subunit
I6G39_RS08500	COG2212	antiporter activity
I6G39_RS08505	COG1320	monovalent cation:proton antiporter activity
I6G39_RS08520	COG2050	protein possibly involved in aromatic compounds catabolism
I6G39_RS08525	COG2056	Na+-H+ antiporter family
I6G39_RS08535	COG1252	NADH dehydrogenase
I6G39_RS08540	COG0316	Belongs to the HesB IscA family
I6G39_RS08545	COG4844	belongs to the
I6G39_RS08550	COG1252	NADH dehydrogenase
I6G39_RS08555	COG4837	Protein of unknown function (DUF1462)
I6G39_RS08560	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I6G39_RS08565	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I6G39_RS08575	COG1696	Membrane protein involved in D-alanine export
I6G39_RS08580	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6G39_RS08595	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6G39_RS08600	COG0647	UMP catabolic process
I6G39_RS08605	COG2445	Protein of unknown function DUF86
I6G39_RS08615	COG4470	Protein conserved in bacteria
I6G39_RS08625	COG0737	Belongs to the 5'-nucleotidase family
I6G39_RS08630	COG0730	response to heat
I6G39_RS08635	COG1801	Protein of unknown function DUF72
I6G39_RS08645	COG1253	flavin adenine dinucleotide binding
I6G39_RS08650	COG5609	conserved protein (DUF2294)
I6G39_RS08655	COG3002	Belongs to the UPF0753 family
I6G39_RS08660	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6G39_RS08680	COG1136	(ABC) transporter
I6G39_RS08680	COG0577	efflux transmembrane transporter activity
I6G39_RS08695	COG0719	Fe-S assembly protein
I6G39_RS08700	COG0822	iron-sulfur transferase activity
I6G39_RS08710	COG0719	Fe-S assembly protein
I6G39_RS08715	COG0396	ATPase activity
I6G39_RS08735	COG1464	Belongs to the NlpA lipoprotein family
I6G39_RS08740	COG2011	ABC-type metal ion transport system permease component
I6G39_RS08745	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6G39_RS08750	COG3118	belongs to the thioredoxin family
I6G39_RS08755	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I6G39_RS08765	COG1393	Belongs to the ArsC family
I6G39_RS08770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G39_RS08780	COG0710	3-dehydroquinate dehydratase activity
I6G39_RS08785	COG1764	response to oxidative stress
I6G39_RS08825	COG2314	TM2 domain
I6G39_RS08835	COG4195	phage-related replication protein
I6G39_RS08840	COG1278	Cold shock
I6G39_RS08870	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6G39_RS08875	COG0557	exoribonuclease II activity
I6G39_RS08880	COG1647	Serine aminopeptidase, S33
I6G39_RS08885	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6G39_RS08895	COG0148	phosphopyruvate hydratase activity
I6G39_RS08900	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6G39_RS08910	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6G39_RS08930	COG1090	epimerase
I6G39_RS08955	COG1481	regulation of sporulation
I6G39_RS08960	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6G39_RS08965	COG1660	Displays ATPase and GTPase activities
I6G39_RS08980	COG0110	maltose O-acetyltransferase activity
I6G39_RS08985	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6G39_RS08990	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I6G39_RS08995	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6G39_RS09000	COG0556	nucleotide-excision repair
I6G39_RS09020	COG0653	protein targeting
I6G39_RS09025	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6G39_RS09030	COG1040	competence protein
I6G39_RS09035	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I6G39_RS09045	COG1739	Uncharacterized protein family UPF0029
I6G39_RS09050	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6G39_RS09055	COG2199	diguanylate cyclase activity
I6G39_RS09070	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6G39_RS09075	COG1929	Belongs to the glycerate kinase type-1 family
I6G39_RS09095	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6G39_RS09110	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6G39_RS09115	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6G39_RS09120	COG1780	Probably involved in ribonucleotide reductase function
I6G39_RS09130	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6G39_RS09135	COG3104	oligopeptide transport
I6G39_RS09140	COG3104	oligopeptide transport
I6G39_RS09145	COG1597	lipid kinase activity
I6G39_RS09155	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6G39_RS09160	COG1174	glycine betaine transport
I6G39_RS09165	COG0517	IMP dehydrogenase activity
I6G39_RS09165	COG1125	glycine betaine transport
I6G39_RS09170	COG0514	ATP-dependent DNA helicase (RecQ)
I6G39_RS09175	COG0488	(ABC) transporter
I6G39_RS09185	COG1368	sulfuric ester hydrolase activity
I6G39_RS09195	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6G39_RS09205	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6G39_RS09210	COG0512	Glutamine amidotransferase of anthranilate synthase
I6G39_RS09215	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6G39_RS09220	COG0720	synthase
I6G39_RS09240	COG0463	Glycosyl transferase, family 2
I6G39_RS09245	COG0656	L-ascorbic acid biosynthetic process
I6G39_RS09250	COG1253	flavin adenine dinucleotide binding
I6G39_RS09255	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6G39_RS09260	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G39_RS09260	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G39_RS09260	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G39_RS09265	COG1105	Belongs to the carbohydrate kinase PfkB family
I6G39_RS09270	COG1349	DNA-binding transcription factor activity
I6G39_RS09275	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6G39_RS09325	COG0523	cobalamin synthesis protein
I6G39_RS09335	COG1968	undecaprenyl-diphosphatase activity
I6G39_RS09345	COG1671	Belongs to the UPF0178 family
I6G39_RS09350	COG1611	Belongs to the LOG family
I6G39_RS09380	COG2814	Major facilitator Superfamily
I6G39_RS09385	COG2839	Protein conserved in bacteria
I6G39_RS09395	COG0583	DNA-binding transcription factor activity
I6G39_RS09410	COG0217	transcriptional regulatory protein
I6G39_RS09420	COG1388	LysM domain
I6G39_RS09420	COG3942	CHAP domain
I6G39_RS09425	COG0306	phosphate transporter
I6G39_RS09430	COG1392	Phosphate transport regulator
I6G39_RS09445	COG3949	Membrane
I6G39_RS09460	COG1461	Dihydroxyacetone kinase
I6G39_RS09465	COG2376	Dihydroxyacetone kinase
I6G39_RS09470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G39_RS09475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G39_RS09480	COG1120	ATPase activity
I6G39_RS09485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G39_RS09490	COG2962	Rard protein
I6G39_RS09495	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6G39_RS09500	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6G39_RS09505	COG1132	(ABC) transporter
I6G39_RS09510	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6G39_RS09515	COG1216	Glycosyl transferase, family 2
I6G39_RS09520	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6G39_RS09525	COG1682	transport, permease protein
I6G39_RS09530	COG1134	teichoic acid transport
I6G39_RS09535	COG5609	conserved protein (DUF2294)
I6G39_RS09545	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6G39_RS09550	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6G39_RS09555	COG1121	(ABC) transporter
I6G39_RS09570	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I6G39_RS09580	COG1320	monovalent cation:proton antiporter activity
I6G39_RS09585	COG2212	antiporter activity
I6G39_RS09590	COG1863	multisubunit Na H antiporter MnhE subunit
I6G39_RS09595	COG0651	ATP synthesis coupled electron transport
I6G39_RS09600	COG1006	Multisubunit Na H antiporter MnhC subunit
I6G39_RS09605	COG2111	Na H antiporter
I6G39_RS09610	COG2111	Na H antiporter
I6G39_RS09610	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6G39_RS09615	COG0582	viral genome integration into host DNA
I6G39_RS09635	COG2814	Major facilitator Superfamily
I6G39_RS09640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6G39_RS09645	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6G39_RS09670	COG3527	Alpha-acetolactate decarboxylase
I6G39_RS09680	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
I6G39_RS09690	COG3949	Membrane
I6G39_RS09695	COG0471	metal ion transport
I6G39_RS09700	COG3942	CHAP domain
I6G39_RS09705	COG0400	carboxylic ester hydrolase activity
I6G39_RS09710	COG0346	lactoylglutathione lyase activity
I6G39_RS09715	COG1846	Transcriptional regulator
I6G39_RS09730	COG0561	phosphatase activity
I6G39_RS09740	COG3764	Sortase (surface protein transpeptidase)
I6G39_RS09750	COG1760	l-serine dehydratase
I6G39_RS09755	COG1760	l-serine dehydratase
I6G39_RS09775	COG2814	Major facilitator Superfamily
I6G39_RS09795	COG0463	Glycosyl transferase, family 2
I6G39_RS09795	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6G39_RS09800	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6G39_RS09810	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6G39_RS09810	COG1215	transferase activity, transferring glycosyl groups
I6G39_RS09815	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6G39_RS09815	COG1215	transferase activity, transferring glycosyl groups
I6G39_RS09820	COG1216	Glycosyl transferase, family 2
I6G39_RS09820	COG0463	Glycosyl transferase, family 2
I6G39_RS09825	COG1129	ABC transporter
I6G39_RS09855	COG2843	Capsule synthesis protein
I6G39_RS09880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G39_RS09885	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6G39_RS09900	COG1288	antiporter activity
I6G39_RS09910	COG0028	Belongs to the TPP enzyme family
I6G39_RS09915	COG0583	DNA-binding transcription factor activity
I6G39_RS09925	COG1757	Na H antiporter
I6G39_RS09930	COG3942	CHAP domain
I6G39_RS09930	COG1388	LysM domain
I6G39_RS09940	COG0183	Belongs to the thiolase family
I6G39_RS09945	COG3425	synthase
I6G39_RS09950	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6G39_RS09955	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6G39_RS09965	COG1012	belongs to the aldehyde dehydrogenase family
I6G39_RS09995	COG0110	maltose O-acetyltransferase activity
I6G39_RS10005	COG0596	Alpha beta hydrolase
I6G39_RS10010	COG2217	Heavy metal translocating P-type atpase
I6G39_RS10015	COG2608	mercury ion transmembrane transporter activity
I6G39_RS10025	COG0436	Aminotransferase
I6G39_RS10030	COG0741	lytic transglycosylase activity
I6G39_RS10045	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G39_RS10055	COG1113	amino acid transport
I6G39_RS10060	COG1028	Short-chain dehydrogenase reductase Sdr
I6G39_RS10065	COG0596	Alpha beta hydrolase
I6G39_RS10070	COG3001	Fructosamine kinase
I6G39_RS10075	COG0167	dihydroorotate dehydrogenase activity
I6G39_RS10085	COG0531	amino acid
I6G39_RS10090	COG3949	Membrane
I6G39_RS10100	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
I6G39_RS10100	COG4932	domain protein
I6G39_RS10100	COG3266	domain, Protein
I6G39_RS10115	COG0626	cystathionine gamma-synthase activity
I6G39_RS10120	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6G39_RS10125	COG1464	Belongs to the NlpA lipoprotein family
I6G39_RS10135	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6G39_RS10150	COG1126	abc transporter atp-binding protein
I6G39_RS10155	COG0765	amino acid transport
I6G39_RS10160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G39_RS10165	COG2843	Capsule synthesis protein
I6G39_RS10170	COG0346	lactoylglutathione lyase activity
I6G39_RS10180	COG0431	NADPH-dependent FMN reductase
I6G39_RS10185	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I6G39_RS10190	COG1012	belongs to the aldehyde dehydrogenase family
I6G39_RS10195	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6G39_RS10200	COG3588	fructose-bisphosphate aldolase
I6G39_RS10215	COG3961	Belongs to the TPP enzyme family
I6G39_RS10230	COG3942	CHAP domain
I6G39_RS10230	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6G39_RS10235	COG4509	Sortase family
I6G39_RS10240	COG1120	ATPase activity
I6G39_RS10270	COG1215	transferase activity, transferring glycosyl groups
I6G39_RS10270	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6G39_RS10285	COG0579	oxidoreductase
I6G39_RS10295	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6G39_RS10305	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
I6G39_RS10310	COG3942	CHAP domain
I6G39_RS10310	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6G39_RS10320	COG1136	(ABC) transporter
I6G39_RS10325	COG0577	efflux transmembrane transporter activity
I6G39_RS10330	COG0577	efflux transmembrane transporter activity
I6G39_RS10335	COG1136	(ABC) transporter
I6G39_RS10360	COG2807	transmembrane transport
I6G39_RS10375	COG0668	transmembrane transport
I6G39_RS10395	COG1063	alcohol dehydrogenase
I6G39_RS10400	COG1063	alcohol dehydrogenase
I6G39_RS10415	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G39_RS10420	COG1876	peptidase activity
I6G39_RS10520	COG1609	Transcriptional regulator
I6G39_RS10530	COG1178	ABC-type Fe3 transport system permease component
I6G39_RS10535	COG3842	ATPase activity
I6G39_RS10540	COG1840	ABC-type Fe3 transport system, periplasmic component
I6G39_RS10545	COG2610	gluconate transmembrane transporter activity
I6G39_RS10550	COG2188	Transcriptional regulator
I6G39_RS10555	COG2084	Dehydrogenase
I6G39_RS10565	COG2610	gluconate transmembrane transporter activity
I6G39_RS10570	COG0191	fructose-bisphosphate aldolase activity
I6G39_RS10610	COG1073	alpha beta