locus-tag	class	description
FRG19_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FRG19_RS00010	COG0592	DNA-directed DNA polymerase activity
FRG19_RS00015	COG2501	S4 domain
FRG19_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FRG19_RS00025	COG0187	DNA topoisomerase II activity
FRG19_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FRG19_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FRG19_RS00045	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FRG19_RS00060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FRG19_RS00070	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
FRG19_RS00075	COG0359	binds to the 23S rRNA
FRG19_RS00080	COG0305	Participates in initiation and elongation during chromosome replication
FRG19_RS00085	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FRG19_RS00100	COG0745	RESPONSE REGULATOR receiver
FRG19_RS00105	COG5002	protein histidine kinase activity
FRG19_RS00110	COG4863	YycH protein
FRG19_RS00120	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FRG19_RS00125	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FRG19_RS00145	COG0202	RNA polymerase activity
FRG19_RS00160	COG0513	Belongs to the DEAD box helicase family
FRG19_RS00170	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FRG19_RS00175	COG1755	Isoprenylcysteine carboxyl methyltransferase
FRG19_RS00180	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FRG19_RS00190	COG1136	(ABC) transporter
FRG19_RS00225	COG0745	RESPONSE REGULATOR receiver
FRG19_RS00230	COG2205	protein histidine kinase activity
FRG19_RS00235	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FRG19_RS00240	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FRG19_RS00270	COG0601	transmembrane transport
FRG19_RS00280	COG0444	Belongs to the ABC transporter superfamily
FRG19_RS00300	COG1309	transcriptional regulator
FRG19_RS00305	COG3246	L-lysine catabolic process to acetate
FRG19_RS00310	COG1250	3-hydroxyacyl-CoA dehydrogenase
FRG19_RS00335	COG1174	glycine betaine transport
FRG19_RS00350	COG1114	Component of the transport system for branched-chain amino acids
FRG19_RS00355	COG1288	antiporter activity
FRG19_RS00360	COG0549	Belongs to the carbamate kinase family
FRG19_RS00375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FRG19_RS00380	COG0477	Major facilitator Superfamily
FRG19_RS00400	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FRG19_RS00420	COG2814	Major facilitator Superfamily
FRG19_RS00430	COG1028	Short-chain dehydrogenase reductase Sdr
FRG19_RS00455	COG2814	Major facilitator Superfamily
FRG19_RS00480	COG2814	Major facilitator Superfamily
FRG19_RS00485	COG0583	DNA-binding transcription factor activity
FRG19_RS00490	COG2318	DinB family
FRG19_RS00495	COG2311	Membrane
FRG19_RS00500	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
FRG19_RS00510	COG0471	metal ion transport
FRG19_RS00525	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
FRG19_RS00530	COG1054	Belongs to the UPF0176 family
FRG19_RS00535	COG3386	PFAM SMP-30 Gluconolaconase
FRG19_RS00540	COG2353	YceI-like domain
FRG19_RS00550	COG0579	oxidoreductase
FRG19_RS00570	COG1686	Belongs to the peptidase S11 family
FRG19_RS00605	COG0726	polysaccharide deacetylase
FRG19_RS00635	COG2814	Major facilitator Superfamily
FRG19_RS00645	COG0737	Belongs to the 5'-nucleotidase family
FRG19_RS00660	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
FRG19_RS00665	COG3639	organic phosphonate transmembrane transporter activity
FRG19_RS00675	COG0702	epimerase
FRG19_RS00690	COG0201	protein transport
FRG19_RS00700	COG1073	alpha beta
FRG19_RS00710	COG0653	protein targeting
FRG19_RS00720	COG0438	transferase activity, transferring glycosyl groups
FRG19_RS00755	COG2814	Major facilitator Superfamily
FRG19_RS00760	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FRG19_RS00765	COG0604	alcohol dehydrogenase
FRG19_RS00780	COG2113	Glycine betaine
FRG19_RS00785	COG2409	Drug exporters of the RND superfamily
FRG19_RS00800	COG0583	DNA-binding transcription factor activity
FRG19_RS00805	COG3842	ATPase activity
FRG19_RS00810	COG1840	ABC-type Fe3 transport system, periplasmic component
FRG19_RS00820	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FRG19_RS00825	COG1764	response to oxidative stress
FRG19_RS00840	COG1705	Flagellar rod assembly protein muramidase FlgJ
FRG19_RS00840	COG3942	CHAP domain
FRG19_RS00840	COG1705	Flagellar rod assembly protein muramidase FlgJ
FRG19_RS00840	COG3942	CHAP domain
FRG19_RS00850	COG1482	cell wall glycoprotein biosynthetic process
FRG19_RS00855	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FRG19_RS00855	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FRG19_RS00855	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FRG19_RS00860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FRG19_RS00860	COG3711	transcriptional antiterminator
FRG19_RS00900	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FRG19_RS00935	COG2235	arginine
FRG19_RS00940	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FRG19_RS00955	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FRG19_RS00970	COG2843	Capsule synthesis protein
FRG19_RS00990	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FRG19_RS00995	COG3961	Belongs to the TPP enzyme family
FRG19_RS01000	COG1846	Transcriptional regulator
FRG19_RS01015	COG4195	phage-related replication protein
FRG19_RS01020	COG4195	phage-related replication protein
FRG19_RS01025	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FRG19_RS01035	COG0702	epimerase
FRG19_RS01040	COG1785	Belongs to the alkaline phosphatase family
FRG19_RS01050	COG0745	RESPONSE REGULATOR receiver
FRG19_RS01055	COG2205	protein histidine kinase activity
FRG19_RS01060	COG1136	(ABC) transporter
FRG19_RS01075	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FRG19_RS01095	COG0386	Belongs to the glutathione peroxidase family
FRG19_RS01100	COG0175	sulfate reduction
FRG19_RS01105	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FRG19_RS01110	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FRG19_RS01125	COG0730	response to heat
FRG19_RS01130	COG2046	Belongs to the sulfate adenylyltransferase family
FRG19_RS01135	COG0529	Catalyzes the synthesis of activated sulfate
FRG19_RS01140	COG2851	Citrate transporter
FRG19_RS01160	COG0602	queuosine metabolic process
FRG19_RS01165	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FRG19_RS01175	COG1510	regulation of RNA biosynthetic process
FRG19_RS01180	COG1012	belongs to the aldehyde dehydrogenase family
FRG19_RS01185	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
FRG19_RS01190	COG1473	amidohydrolase
FRG19_RS01210	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FRG19_RS01215	COG0574	Belongs to the PEP-utilizing enzyme family
FRG19_RS01215	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FRG19_RS01220	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FRG19_RS01225	COG0579	oxidoreductase
FRG19_RS01245	COG3588	fructose-bisphosphate aldolase
FRG19_RS01250	COG0446	pyridine nucleotide-disulphide oxidoreductase
FRG19_RS01275	COG0531	amino acid
FRG19_RS01285	COG0583	DNA-binding transcription factor activity
FRG19_RS01290	COG0039	L-malate dehydrogenase activity
FRG19_RS01295	COG0028	Belongs to the TPP enzyme family
FRG19_RS01300	COG3527	Alpha-acetolactate decarboxylase
FRG19_RS01310	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FRG19_RS01315	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FRG19_RS01330	COG4640	response to antibiotic
FRG19_RS01355	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FRG19_RS01365	COG0167	dihydroorotate dehydrogenase activity
FRG19_RS01370	COG3001	Fructosamine kinase
FRG19_RS01385	COG0596	Alpha beta hydrolase
FRG19_RS01395	COG1028	Short-chain dehydrogenase reductase Sdr
FRG19_RS01420	COG1113	amino acid transport
FRG19_RS01440	COG0741	lytic transglycosylase activity
FRG19_RS01450	COG3179	chitinase
FRG19_RS01455	COG2755	lipolytic protein G-D-S-L family
FRG19_RS01455	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FRG19_RS01460	COG3942	CHAP domain
FRG19_RS01490	COG0436	Aminotransferase
FRG19_RS01505	COG2608	mercury ion transmembrane transporter activity
FRG19_RS01510	COG2217	Heavy metal translocating P-type atpase
FRG19_RS01520	COG1028	Short-chain dehydrogenase reductase Sdr
FRG19_RS01530	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
FRG19_RS01535	COG1012	belongs to the aldehyde dehydrogenase family
FRG19_RS01570	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FRG19_RS01575	COG3425	synthase
FRG19_RS01595	COG0583	DNA-binding transcription factor activity
FRG19_RS01600	COG1380	Effector of murein hydrolase LrgA
FRG19_RS01605	COG1346	cytolysis
FRG19_RS01610	COG0028	Belongs to the TPP enzyme family
FRG19_RS01620	COG1266	CAAX protease self-immunity
FRG19_RS01635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FRG19_RS01640	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FRG19_RS01650	COG0697	spore germination
FRG19_RS01655	COG2207	Transcriptional regulator
FRG19_RS01655	COG1917	Cupin 2, conserved barrel domain protein
FRG19_RS01665	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FRG19_RS01675	COG2843	Capsule synthesis protein
FRG19_RS01690	COG4975	Glucose uptake
FRG19_RS01695	COG1869	D-ribose catabolic process
FRG19_RS01705	COG1070	Carbohydrate kinase
FRG19_RS01720	COG1760	l-serine dehydratase
FRG19_RS01725	COG1760	l-serine dehydratase
FRG19_RS01735	COG1247	-acetyltransferase
FRG19_RS01740	COG3764	Sortase (surface protein transpeptidase)
FRG19_RS01745	COG0561	phosphatase activity
FRG19_RS01755	COG0778	Nitroreductase
FRG19_RS01760	COG1012	belongs to the aldehyde dehydrogenase family
FRG19_RS01765	COG2514	catechol 2,3-dioxygenase activity
FRG19_RS01785	COG3949	Membrane
FRG19_RS01795	COG1476	TRANSCRIPTIONal
FRG19_RS01805	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
FRG19_RS01810	COG0586	Pfam SNARE associated Golgi protein
FRG19_RS01820	COG2022	thiamine diphosphate biosynthetic process
FRG19_RS01830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FRG19_RS01840	COG2271	Major facilitator Superfamily
FRG19_RS01855	COG4876	unkown
FRG19_RS01860	COG2357	RelA SpoT domain protein
FRG19_RS01870	COG1802	Transcriptional regulator
FRG19_RS01875	COG1070	Carbohydrate kinase
FRG19_RS01880	COG2610	gluconate transmembrane transporter activity
FRG19_RS01885	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FRG19_RS01890	COG1215	transferase activity, transferring glycosyl groups
FRG19_RS01905	COG4221	oxidoreductase activity
FRG19_RS01910	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FRG19_RS01915	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FRG19_RS01925	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FRG19_RS01930	COG1028	Short-chain dehydrogenase reductase Sdr
FRG19_RS01940	COG1363	Peptidase, m42
FRG19_RS01945	COG4808	Protein conserved in bacteria
FRG19_RS01950	COG0069	glutamate synthase activity
FRG19_RS01965	COG4619	ABC transporter
FRG19_RS01970	COG0390	transport system, permease component
FRG19_RS01975	COG2814	Major facilitator Superfamily
FRG19_RS01980	COG2272	Belongs to the type-B carboxylesterase lipase family
FRG19_RS01985	COG0531	amino acid
FRG19_RS01990	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
FRG19_RS01995	COG1063	alcohol dehydrogenase
FRG19_RS02015	COG1174	glycine betaine transport
FRG19_RS02020	COG1346	cytolysis
FRG19_RS02025	COG1380	Effector of murein hydrolase LrgA
FRG19_RS02035	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FRG19_RS02050	COG0706	membrane insertase activity
FRG19_RS02080	COG4555	ABC transporter
FRG19_RS02185	COG3173	Aminoglycoside phosphotransferase
FRG19_RS02210	COG1230	cation diffusion facilitator family transporter
FRG19_RS02220	COG1937	Protein conserved in bacteria
FRG19_RS02225	COG2217	Heavy metal translocating P-type atpase
FRG19_RS02270	COG1113	amino acid transport
FRG19_RS02290	COG2814	Major facilitator Superfamily
FRG19_RS02300	COG1929	Belongs to the glycerate kinase type-1 family
FRG19_RS02315	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FRG19_RS02320	COG0741	lytic transglycosylase activity
FRG19_RS02325	COG0588	phosphoglycerate mutase activity
FRG19_RS02335	COG2814	Major facilitator Superfamily
FRG19_RS02340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FRG19_RS02345	COG0765	amino acid transport
FRG19_RS02350	COG1126	abc transporter atp-binding protein
FRG19_RS02360	COG2348	transferase activity, transferring amino-acyl groups
FRG19_RS02395	COG0454	-acetyltransferase
FRG19_RS02400	COG0747	negative chemotaxis
FRG19_RS02410	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FRG19_RS02415	COG2146	nitrite reductase [NAD(P)H] activity
FRG19_RS02425	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
FRG19_RS02430	COG1140	nitrate reductase beta subunit
FRG19_RS02440	COG2181	nitrate reductase activity
FRG19_RS02450	COG4585	Histidine kinase
FRG19_RS02455	COG2197	response regulator
FRG19_RS02460	COG2223	nitrite transmembrane transporter activity
FRG19_RS02475	COG0778	Nitroreductase
FRG19_RS02495	COG3871	stress protein (general stress protein 26)
FRG19_RS02500	COG4753	response regulator
FRG19_RS02500	COG2207	Transcriptional regulator
FRG19_RS02515	COG1263	PTS System
FRG19_RS02515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FRG19_RS02550	COG0492	ferredoxin-NADP+ reductase activity
FRG19_RS02560	COG0604	alcohol dehydrogenase
FRG19_RS02565	COG2822	iron ion transport
FRG19_RS02570	COG2837	iron assimilation
FRG19_RS02575	COG0672	)-iron permease
FRG19_RS02580	COG0805	protein transport
FRG19_RS02585	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FRG19_RS02595	COG0463	Glycosyl transferase, family 2
FRG19_RS02595	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FRG19_RS02605	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FRG19_RS02610	COG1620	l-lactate permease
FRG19_RS02620	COG0579	oxidoreductase
FRG19_RS02625	COG5002	protein histidine kinase activity
FRG19_RS02625	COG3850	Histidine kinase
FRG19_RS02630	COG0745	RESPONSE REGULATOR receiver
FRG19_RS02655	COG4640	response to antibiotic
FRG19_RS02670	COG1566	PFAM secretion protein HlyD family protein
FRG19_RS02675	COG2814	Major facilitator Superfamily
FRG19_RS02700	COG0598	Magnesium transport protein CorA
FRG19_RS02705	COG1304	FMN binding
FRG19_RS02710	COG0786	glutamate:sodium symporter activity
FRG19_RS02730	COG2094	Belongs to the DNA glycosylase MPG family
FRG19_RS02735	COG3152	Membrane
FRG19_RS02750	COG1069	ribulokinase activity
FRG19_RS02755	COG4152	abc transporter atp-binding protein
FRG19_RS02760	COG1668	transmembrane transport
FRG19_RS02765	COG1742	UPF0060 membrane protein
FRG19_RS02775	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FRG19_RS02780	COG1266	CAAX protease self-immunity
FRG19_RS02785	COG0010	Belongs to the arginase family
FRG19_RS02790	COG0583	DNA-binding transcription factor activity
FRG19_RS02805	COG0659	secondary active sulfate transmembrane transporter activity
FRG19_RS02810	COG1473	amidohydrolase
FRG19_RS02815	COG1028	Short-chain dehydrogenase reductase Sdr
FRG19_RS02840	COG1737	Transcriptional regulator
FRG19_RS02845	COG1263	PTS System
FRG19_RS02845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FRG19_RS02855	COG0385	Bile acid
FRG19_RS02860	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FRG19_RS02880	COG1113	amino acid transport
FRG19_RS02890	COG1263	PTS System
FRG19_RS02890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FRG19_RS02895	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FRG19_RS02925	COG1316	TRANSCRIPTIONal
FRG19_RS02955	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FRG19_RS02960	COG2076	Multidrug Resistance protein
FRG19_RS02965	COG2076	Multidrug Resistance protein
FRG19_RS02970	COG3942	CHAP domain
FRG19_RS02985	COG1757	Na H antiporter
FRG19_RS02990	COG3942	CHAP domain
FRG19_RS03015	COG0829	nickel cation binding
FRG19_RS03030	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
FRG19_RS03035	COG0804	urea catabolic process
FRG19_RS03045	COG0831	urea catabolic process
FRG19_RS03050	COG4413	Urea transporter
FRG19_RS03055	COG1960	acyl-CoA dehydrogenase activity
FRG19_RS03060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FRG19_RS03070	COG1268	BioY protein
FRG19_RS03085	COG0725	ABC transporter, periplasmic molybdate-binding protein
FRG19_RS03090	COG4149	molybdate abc transporter
FRG19_RS03095	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FRG19_RS03100	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FRG19_RS03105	COG0521	Mo-molybdopterin cofactor biosynthetic process
FRG19_RS03110	COG0315	cyclic pyranopterin monophosphate synthase activity
FRG19_RS03115	COG0303	'Molybdopterin
FRG19_RS03120	COG1763	Mo-molybdopterin cofactor biosynthetic process
FRG19_RS03135	COG0746	molybdenum cofactor guanylyltransferase activity
FRG19_RS03140	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FRG19_RS03150	COG2814	Major facilitator Superfamily
FRG19_RS03170	COG2348	transferase activity, transferring amino-acyl groups
FRG19_RS03175	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FRG19_RS03200	COG4975	Glucose uptake
FRG19_RS03210	COG0551	DNA topoisomerase type I activity
FRG19_RS03210	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FRG19_RS03215	COG2252	PERMEase
FRG19_RS03230	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FRG19_RS03235	COG0088	Forms part of the polypeptide exit tunnel
FRG19_RS03240	COG0089	rRNA binding
FRG19_RS03245	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FRG19_RS03250	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FRG19_RS03260	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FRG19_RS03265	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FRG19_RS03275	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FRG19_RS03280	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FRG19_RS03285	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FRG19_RS03290	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FRG19_RS03295	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FRG19_RS03300	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FRG19_RS03305	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FRG19_RS03310	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FRG19_RS03315	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FRG19_RS03320	COG1841	ribosomal large subunit assembly
FRG19_RS03325	COG0200	Binds to the 23S rRNA
FRG19_RS03330	COG0201	protein transport
FRG19_RS03335	COG0563	adenylate kinase activity
FRG19_RS03340	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FRG19_RS03345	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FRG19_RS03350	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FRG19_RS03360	COG0202	RNA polymerase activity
FRG19_RS03365	COG0203	ribosomal protein L17
FRG19_RS03370	COG1122	ATPase activity
FRG19_RS03375	COG1122	ATPase activity
FRG19_RS03385	COG0101	tRNA pseudouridine synthase activity
FRG19_RS03390	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FRG19_RS03400	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FRG19_RS03405	COG1349	DNA-binding transcription factor activity
FRG19_RS03410	COG0698	ribose 5-phosphate isomerase
FRG19_RS03435	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FRG19_RS03435	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FRG19_RS03455	COG2130	NADP-dependent
FRG19_RS03460	COG0604	alcohol dehydrogenase
FRG19_RS03465	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FRG19_RS03480	COG1302	Protein conserved in bacteria
FRG19_RS03485	COG4264	IucA IucC family
FRG19_RS03490	COG2814	Major facilitator Superfamily
FRG19_RS03495	COG4264	IucA IucC family
FRG19_RS03500	COG3457	Alanine racemase
FRG19_RS03505	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FRG19_RS03510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FRG19_RS03515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FRG19_RS03520	COG3314	Sporulation integral membrane protein YlbJ
FRG19_RS03525	COG2329	Antibiotic biosynthesis monooxygenase
FRG19_RS03535	COG1988	membrane-bound metal-dependent
FRG19_RS03540	COG4284	Utp--glucose-1-phosphate uridylyltransferase
FRG19_RS03545	COG1272	protein, Hemolysin III
FRG19_RS03560	COG2814	Major facilitator Superfamily
FRG19_RS03565	COG0489	protein tyrosine kinase activity
FRG19_RS03620	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
FRG19_RS03630	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FRG19_RS03645	COG3711	transcriptional antiterminator
FRG19_RS03655	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FRG19_RS03660	COG0561	phosphatase activity
FRG19_RS03680	COG0640	Transcriptional regulator
FRG19_RS03685	COG0702	epimerase
FRG19_RS03690	COG1482	cell wall glycoprotein biosynthetic process
FRG19_RS03710	COG0783	Belongs to the Dps family
FRG19_RS03715	COG0813	purine-nucleoside phosphorylase activity
FRG19_RS03720	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FRG19_RS03725	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
FRG19_RS03730	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FRG19_RS03745	COG1854	S-ribosylhomocysteine lyase activity
FRG19_RS03765	COG5146	pantothenate kinase activity
FRG19_RS03775	COG3343	RNA polymerase activity
FRG19_RS03780	COG0504	CTP synthase activity
FRG19_RS03790	COG0191	fructose-bisphosphate aldolase activity
FRG19_RS03795	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FRG19_RS03805	COG1012	belongs to the aldehyde dehydrogenase family
FRG19_RS03810	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FRG19_RS03815	COG0254	rRNA binding
FRG19_RS03820	COG1435	thymidine kinase activity
FRG19_RS03830	COG2890	protein-(glutamine-N5) methyltransferase activity
FRG19_RS03835	COG0009	L-threonylcarbamoyladenylate synthase
FRG19_RS03840	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FRG19_RS03845	COG4475	Protein of unknown function (DUF436)
FRG19_RS03850	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FRG19_RS03855	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FRG19_RS03860	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FRG19_RS03870	COG0356	it plays a direct role in the translocation of protons across the membrane
FRG19_RS03880	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FRG19_RS03885	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FRG19_RS03890	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FRG19_RS03895	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FRG19_RS03900	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FRG19_RS03905	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FRG19_RS03915	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FRG19_RS03920	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FRG19_RS03930	COG0629	single-stranded DNA binding
FRG19_RS03935	COG1388	LysM domain
FRG19_RS03940	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FRG19_RS03950	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
FRG19_RS03955	COG0352	thiamine-phosphate diphosphorylase activity
FRG19_RS03960	COG0706	membrane insertase activity
FRG19_RS03965	COG1418	mRNA catabolic process
FRG19_RS03970	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FRG19_RS03975	COG1937	Protein conserved in bacteria
FRG19_RS03990	COG0772	Belongs to the SEDS family
FRG19_RS03995	COG1181	Belongs to the D-alanine--D-alanine ligase family
FRG19_RS04000	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FRG19_RS04005	COG0513	Belongs to the DEAD box helicase family
FRG19_RS04020	COG3402	PFAM membrane-flanked domain
FRG19_RS04030	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FRG19_RS04040	COG2337	Toxic component of a toxin-antitoxin (TA) module
FRG19_RS04045	COG2208	phosphoserine phosphatase activity
FRG19_RS04060	COG1191	sigma factor activity
FRG19_RS04065	COG2183	response to ionizing radiation
FRG19_RS04070	COG3091	SprT-like family
FRG19_RS04105	COG0066	3-isopropylmalate dehydratase activity
FRG19_RS04110	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FRG19_RS04115	COG0473	3-isopropylmalate dehydrogenase activity
FRG19_RS04120	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FRG19_RS04125	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FRG19_RS04135	COG0028	Belongs to the TPP enzyme family
FRG19_RS04140	COG0129	dihydroxy-acid dehydratase activity
FRG19_RS04145	COG0802	atpase or kinase
FRG19_RS04150	COG1214	PFAM Peptidase M22, glycoprotease
FRG19_RS04155	COG0456	acetyltransferase
FRG19_RS04160	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FRG19_RS04165	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FRG19_RS04170	COG0488	(ABC) transporter
FRG19_RS04175	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
FRG19_RS04185	COG2391	methyltransferase activity
FRG19_RS04190	COG0425	Belongs to the sulfur carrier protein TusA family
FRG19_RS04195	COG0004	ammonium transporteR
FRG19_RS04200	COG1609	Transcriptional regulator
FRG19_RS04205	COG1621	beta-fructofuranosidase activity
FRG19_RS04210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FRG19_RS04215	COG3279	Response regulator of the LytR AlgR family
FRG19_RS04220	COG3290	protein histidine kinase activity
FRG19_RS04260	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FRG19_RS04265	COG0459	protein refolding
FRG19_RS04290	COG1725	Transcriptional regulator
FRG19_RS04305	COG1131	(ABC) transporter
FRG19_RS04350	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FRG19_RS04355	COG2706	6-phosphogluconolactonase activity
FRG19_RS04360	COG1012	belongs to the aldehyde dehydrogenase family
FRG19_RS04365	COG1227	inorganic diphosphatase activity
FRG19_RS04370	COG1335	isochorismatase
FRG19_RS04380	COG0077	Prephenate dehydratase
FRG19_RS04390	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FRG19_RS04395	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FRG19_RS04400	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
FRG19_RS04415	COG4496	protein, YerC YecD
FRG19_RS04470	COG2706	6-phosphogluconolactonase activity
FRG19_RS04475	COG1012	belongs to the aldehyde dehydrogenase family
FRG19_RS04480	COG1227	inorganic diphosphatase activity
FRG19_RS04485	COG1335	isochorismatase
FRG19_RS04495	COG0077	Prephenate dehydratase
FRG19_RS04505	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FRG19_RS04510	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FRG19_RS04515	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
FRG19_RS04525	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FRG19_RS04530	COG4496	protein, YerC YecD
FRG19_RS04535	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
FRG19_RS04540	COG0210	DNA helicase
FRG19_RS04545	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FRG19_RS04555	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FRG19_RS04560	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FRG19_RS04565	COG0154	amidase activity
FRG19_RS04570	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FRG19_RS04575	COG1597	lipid kinase activity
FRG19_RS04580	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FRG19_RS04600	COG1528	Iron-storage protein
FRG19_RS04620	COG4129	membrane
FRG19_RS04625	COG0024	Methionine aminopeptidase
FRG19_RS04645	COG2197	response regulator
FRG19_RS04650	COG1295	ribonuclease BN
FRG19_RS04660	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FRG19_RS04665	COG4840	Belongs to the UPF0435 family
FRG19_RS04670	COG2309	aminopeptidase activity
FRG19_RS04675	COG1607	acyl-coa hydrolase
FRG19_RS04680	COG0535	radical SAM domain protein
FRG19_RS04690	COG0693	protein deglycase activity
FRG19_RS04695	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FRG19_RS04700	COG2137	regulation of response to DNA damage stimulus
FRG19_RS04710	COG1388	LysM domain
FRG19_RS04710	COG1134	teichoic acid transport
FRG19_RS04720	COG1988	membrane-bound metal-dependent
FRG19_RS04730	COG3557	Belongs to the UPF0374 family
FRG19_RS04740	COG4129	membrane
FRG19_RS04745	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FRG19_RS04750	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FRG19_RS04755	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FRG19_RS04760	COG0735	belongs to the Fur family
FRG19_RS04945	COG1126	abc transporter atp-binding protein
FRG19_RS04950	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FRG19_RS04960	COG0363	glucosamine-6-phosphate deaminase activity
FRG19_RS04975	COG0114	fumarate hydratase activity
FRG19_RS04980	COG0564	pseudouridine synthase activity
FRG19_RS04985	COG2203	Gaf domain
FRG19_RS04985	COG4585	Histidine kinase
FRG19_RS04990	COG2197	response regulator
FRG19_RS05000	COG4399	Belongs to the UPF0754 family
FRG19_RS05005	COG3679	Belongs to the UPF0342 family
FRG19_RS05010	COG0420	3'-5' exonuclease activity
FRG19_RS05015	COG4717	serine-type aminopeptidase activity
FRG19_RS05020	COG3481	metal-dependent phosphohydrolase, HD sub domain
FRG19_RS05030	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FRG19_RS05045	COG0537	adenosine 5'-monophosphoramidase activity
FRG19_RS05050	COG1131	(ABC) transporter
FRG19_RS05055	COG4473	ABC transporter
FRG19_RS05060	COG2329	Antibiotic biosynthesis monooxygenase
FRG19_RS05065	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FRG19_RS05070	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FRG19_RS05075	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
FRG19_RS05125	COG0318	PFAM AMP-dependent synthetase and ligase
FRG19_RS05140	COG0494	nUDIX hydrolase
FRG19_RS05145	COG1506	peptidase
FRG19_RS05155	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FRG19_RS05165	COG0656	L-ascorbic acid biosynthetic process
FRG19_RS05170	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FRG19_RS05175	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FRG19_RS05185	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FRG19_RS05200	COG1595	DNA-templated transcription, initiation
FRG19_RS05210	COG5632	N-Acetylmuramoyl-L-alanine amidase
FRG19_RS05210	COG4193	domain, Protein
FRG19_RS05210	COG3266	domain, Protein
FRG19_RS05220	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FRG19_RS05220	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FRG19_RS05230	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FRG19_RS05230	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FRG19_RS05235	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FRG19_RS05240	COG0506	proline dehydrogenase activity
FRG19_RS05245	COG2267	carboxylic ester hydrolase activity
FRG19_RS05255	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
FRG19_RS05260	COG1242	4 iron, 4 sulfur cluster binding
FRG19_RS05265	COG2814	Major facilitator Superfamily
FRG19_RS05270	COG0495	leucyl-tRNA aminoacylation
FRG19_RS05275	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FRG19_RS05285	COG2081	HI0933 family
FRG19_RS05290	COG2244	polysaccharide biosynthetic process
FRG19_RS05295	COG1187	pseudouridine synthase activity
FRG19_RS05305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FRG19_RS05310	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FRG19_RS05315	COG0510	thiamine kinase activity
FRG19_RS05320	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FRG19_RS05325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FRG19_RS05335	COG1363	Peptidase, m42
FRG19_RS05340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FRG19_RS05345	COG4848	Belongs to the UPF0354 family
FRG19_RS05350	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FRG19_RS05355	COG1674	ftsk spoiiie
FRG19_RS05360	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FRG19_RS05365	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
FRG19_RS05375	COG1605	Chorismate mutase
FRG19_RS05375	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
FRG19_RS05380	COG1609	Transcriptional regulator
FRG19_RS05390	COG0454	-acetyltransferase
FRG19_RS05400	COG2759	Belongs to the formate--tetrahydrofolate ligase family
FRG19_RS05405	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FRG19_RS05410	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FRG19_RS05420	COG2814	Major facilitator Superfamily
FRG19_RS05425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FRG19_RS05430	COG0204	Acyl-transferase
FRG19_RS05435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FRG19_RS05435	COG1263	PTS System
FRG19_RS05445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FRG19_RS05455	COG1764	response to oxidative stress
FRG19_RS05460	COG0584	glycerophosphoryl diester phosphodiesterase
FRG19_RS05465	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FRG19_RS05470	COG1956	GAF domain-containing protein
FRG19_RS05475	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
FRG19_RS05480	COG1104	cysteine desulfurase activity
FRG19_RS05485	COG0301	tRNA thio-modification
FRG19_RS05495	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
FRG19_RS05500	COG0827	DNA restriction-modification system
FRG19_RS05505	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FRG19_RS05510	COG0589	response to stress
FRG19_RS05520	COG0006	proline dipeptidase activity
FRG19_RS05525	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FRG19_RS05535	COG4109	DRTGG domain
FRG19_RS05540	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FRG19_RS05545	COG0587	DNA-directed DNA polymerase activity
FRG19_RS05555	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FRG19_RS05560	COG0825	malonyl-CoA metabolic process
FRG19_RS05565	COG0205	6-phosphofructokinase activity
FRG19_RS05570	COG0469	pyruvate kinase activity
FRG19_RS05575	COG1113	amino acid transport
FRG19_RS05580	COG0372	Belongs to the citrate synthase family
FRG19_RS05585	COG0538	isocitrate dehydrogenase activity
FRG19_RS05590	COG0745	RESPONSE REGULATOR receiver
FRG19_RS05595	COG5002	protein histidine kinase activity
FRG19_RS05600	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FRG19_RS05600	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FRG19_RS05610	COG0237	dephospho-CoA kinase activity
FRG19_RS05615	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FRG19_RS05620	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FRG19_RS05630	COG1484	DNA-dependent DNA replication
FRG19_RS05635	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FRG19_RS05640	COG0833	amino acid
FRG19_RS05645	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FRG19_RS05650	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FRG19_RS05655	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FRG19_RS05660	COG4112	unkown
FRG19_RS05670	COG0544	peptidyl-prolyl cis-trans isomerase activity
FRG19_RS05675	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FRG19_RS05680	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FRG19_RS05685	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FRG19_RS05690	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FRG19_RS05695	COG0181	hydroxymethylbilane synthase activity
FRG19_RS05705	COG0113	porphobilinogen synthase activity
FRG19_RS05710	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FRG19_RS05720	COG2818	Glycosylase
FRG19_RS05725	COG0525	valine-tRNA ligase activity
FRG19_RS05730	COG0285	dihydrofolate synthase activity
FRG19_RS05740	COG2003	Belongs to the UPF0758 family
FRG19_RS05775	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FRG19_RS05780	COG2868	ribosomal protein
FRG19_RS05785	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FRG19_RS05790	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FRG19_RS05795	COG4492	Belongs to the UPF0735 family
FRG19_RS05800	COG0632	four-way junction helicase activity
FRG19_RS05805	COG2255	four-way junction helicase activity
FRG19_RS05810	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FRG19_RS05820	COG1862	Preprotein translocase
FRG19_RS05825	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FRG19_RS05825	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FRG19_RS05830	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
FRG19_RS05830	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FRG19_RS05840	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FRG19_RS05845	COG1490	D-aminoacyl-tRNA deacylase activity
FRG19_RS05850	COG0860	N-Acetylmuramoyl-L-alanine amidase
FRG19_RS05860	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FRG19_RS05870	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FRG19_RS05875	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FRG19_RS05880	COG1959	2 iron, 2 sulfur cluster binding
FRG19_RS05890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FRG19_RS05895	COG1104	cysteine desulfurase activity
FRG19_RS05900	COG0482	sulfurtransferase activity
FRG19_RS05910	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FRG19_RS05915	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FRG19_RS05920	COG4472	Bacterial protein of unknown function (DUF965)
FRG19_RS05925	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FRG19_RS05930	COG3906	Belongs to the UPF0473 family
FRG19_RS05940	COG0826	peptidase U32
FRG19_RS05945	COG0826	peptidase U32
FRG19_RS05950	COG0572	uridine kinase
FRG19_RS05955	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FRG19_RS05960	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FRG19_RS05965	COG1984	allophanate hydrolase subunit 2
FRG19_RS05970	COG0511	ligase activity, forming carbon-carbon bonds
FRG19_RS05975	COG0439	Biotin carboxylase
FRG19_RS05980	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FRG19_RS05985	COG1914	H( )-stimulated, divalent metal cation uptake system
FRG19_RS05990	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FRG19_RS05995	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
FRG19_RS06000	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FRG19_RS06010	COG1534	Rna-binding protein
FRG19_RS06015	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FRG19_RS06020	COG1713	HD superfamily hydrolase involved in NAD metabolism
FRG19_RS06025	COG0799	negative regulation of ribosome biogenesis
FRG19_RS06030	COG2226	methyltransferase
FRG19_RS06035	COG1555	photosystem II stabilization
FRG19_RS06035	COG1596	polysaccharide export
FRG19_RS06040	COG2131	deaminase
FRG19_RS06050	COG1466	dna polymerase III delta subunit
FRG19_RS06055	COG0268	Binds directly to 16S ribosomal RNA
FRG19_RS06060	COG0481	GTPase activity
FRG19_RS06065	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FRG19_RS06070	COG1420	regulation of RNA biosynthetic process
FRG19_RS06075	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FRG19_RS06080	COG0443	Heat shock 70 kDa protein
FRG19_RS06085	COG0484	heat shock protein binding
FRG19_RS06090	COG2264	protein methyltransferase activity
FRG19_RS06095	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FRG19_RS06100	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FRG19_RS06110	COG1030	water channel activity
FRG19_RS06115	COG4864	UPF0365 protein
FRG19_RS06125	COG1702	phosphate starvation-inducible protein PhoH
FRG19_RS06130	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FRG19_RS06140	COG0295	cytidine deaminase activity
FRG19_RS06145	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FRG19_RS06150	COG1381	Involved in DNA repair and RecF pathway recombination
FRG19_RS06155	COG0423	glycine-tRNA ligase activity
FRG19_RS06160	COG0517	IMP dehydrogenase activity
FRG19_RS06165	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FRG19_RS06170	COG0358	DNA primase activity
FRG19_RS06175	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FRG19_RS06180	COG2384	SAM-dependent methyltransferase
FRG19_RS06185	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FRG19_RS06190	COG0513	Belongs to the DEAD box helicase family
FRG19_RS06195	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
FRG19_RS06200	COG1121	(ABC) transporter
FRG19_RS06205	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FRG19_RS06220	COG0768	penicillin binding
FRG19_RS06225	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FRG19_RS06230	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FRG19_RS06240	COG4483	Protein conserved in bacteria
FRG19_RS06245	COG1940	carbohydrate kinase activity
FRG19_RS06250	COG0011	TIGRFAM Protein of
FRG19_RS06255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FRG19_RS06260	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FRG19_RS06265	COG1459	type II secretion system
FRG19_RS06270	COG4537	Required for transformation and DNA binding
FRG19_RS06290	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FRG19_RS06295	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FRG19_RS06310	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FRG19_RS06315	COG0095	Lipoate-protein ligase
FRG19_RS06330	COG0006	proline dipeptidase activity
FRG19_RS06335	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FRG19_RS06340	COG0511	ligase activity, forming carbon-carbon bonds
FRG19_RS06345	COG0439	Biotin carboxylase
FRG19_RS06350	COG1302	Protein conserved in bacteria
FRG19_RS06355	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FRG19_RS06360	COG1570	exodeoxyribonuclease VII activity
FRG19_RS06375	COG1438	arginine binding
FRG19_RS06380	COG0497	DNA recombination
FRG19_RS06385	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FRG19_RS06390	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FRG19_RS06395	COG0022	dehydrogenase e1 component
FRG19_RS06400	COG0508	dehydrogenase complex catalyzes the overall conversion of
FRG19_RS06410	COG4129	membrane
FRG19_RS06420	COG2195	Cleaves the N-terminal amino acid of tripeptides
FRG19_RS06425	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FRG19_RS06430	COG0366	Alpha amylase catalytic
FRG19_RS06440	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FRG19_RS06445	COG1234	tRNA 3'-trailer cleavage
FRG19_RS06450	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FRG19_RS06455	COG0300	oxidoreductase activity
FRG19_RS06465	COG0667	Aldo Keto reductase
FRG19_RS06470	COG0494	nUDIX hydrolase
FRG19_RS06475	COG0735	belongs to the Fur family
FRG19_RS06480	COG4974	Belongs to the 'phage' integrase family
FRG19_RS06490	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FRG19_RS06495	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FRG19_RS06500	COG1187	pseudouridine synthase activity
FRG19_RS06505	COG0745	RESPONSE REGULATOR receiver
FRG19_RS06520	COG1141	Ferredoxin
FRG19_RS06530	COG0514	ATP-dependent DNA helicase (RecQ)
FRG19_RS06535	COG1388	LysM domain
FRG19_RS06540	COG0492	ferredoxin-NADP+ reductase activity
FRG19_RS06550	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FRG19_RS06555	COG0539	negative regulation of cytoplasmic translation
FRG19_RS06560	COG1160	GTP binding
FRG19_RS06565	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FRG19_RS06580	COG2226	methyltransferase
FRG19_RS06585	COG0142	geranyltranstransferase activity
FRG19_RS06590	COG0105	UTP biosynthetic process
FRG19_RS06595	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FRG19_RS06600	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FRG19_RS06605	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FRG19_RS06615	COG5582	Belongs to the UPF0302 family
FRG19_RS06620	COG4347	Protein of unknown function (DUF1405)
FRG19_RS06625	COG2738	Putative neutral zinc metallopeptidase
FRG19_RS06630	COG1694	Mazg nucleotide pyrophosphohydrolase
FRG19_RS06635	COG0438	transferase activity, transferring glycosyl groups
FRG19_RS06640	COG0617	tRNA 3'-terminal CCA addition
FRG19_RS06650	COG1199	ATP-dependent helicase activity
FRG19_RS06650	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FRG19_RS06655	COG0017	Asparaginyl-tRNA synthetase
FRG19_RS06660	COG3935	DnaD domain protein
FRG19_RS06665	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FRG19_RS06675	COG4499	WXG100 protein secretion system (Wss), protein YukC
FRG19_RS06675	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FRG19_RS06680	COG3331	DNA recombination
FRG19_RS06690	COG4474	Belongs to the UPF0398 family
FRG19_RS06695	COG3599	regulation of cell shape
FRG19_RS06705	COG0116	Belongs to the methyltransferase superfamily
FRG19_RS06715	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
FRG19_RS06720	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FRG19_RS06730	COG0328	RNA-DNA hybrid ribonuclease activity
FRG19_RS06735	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FRG19_RS06745	COG1413	lyase activity
FRG19_RS06750	COG1413	lyase activity
FRG19_RS06780	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FRG19_RS06785	COG2190	(PTS) system
FRG19_RS06790	COG4479	Belongs to the UPF0346 family
FRG19_RS06795	COG0793	Belongs to the peptidase S41A family
FRG19_RS06805	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FRG19_RS06810	COG0671	phosphoesterase, PA-phosphatase related
FRG19_RS06815	COG3842	ATPase activity
FRG19_RS06820	COG4209	transmembrane transport
FRG19_RS06830	COG0395	ABC-type sugar transport system, permease component
FRG19_RS06840	COG0534	Mate efflux family protein
FRG19_RS06845	COG1349	DNA-binding transcription factor activity
FRG19_RS06850	COG0745	RESPONSE REGULATOR receiver
FRG19_RS06855	COG5002	protein histidine kinase activity
FRG19_RS06860	COG0567	Dehydrogenase, E1 component
FRG19_RS06870	COG3177	Filamentation induced by cAMP protein fic
FRG19_RS06875	COG1131	(ABC) transporter
FRG19_RS06895	COG0714	Associated with various cellular activities
FRG19_RS06900	COG4548	von Willebrand factor, type A
FRG19_RS06905	COG1114	Component of the transport system for branched-chain amino acids
FRG19_RS06910	COG3853	Toxic anion resistance protein (TelA)
FRG19_RS06920	COG1254	Belongs to the acylphosphatase family
FRG19_RS06930	COG1278	Cold shock
FRG19_RS06955	COG1473	amidohydrolase
FRG19_RS06965	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FRG19_RS06970	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FRG19_RS06975	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FRG19_RS06980	COG0527	aspartate kinase activity
FRG19_RS06985	COG0488	(ABC) transporter
FRG19_RS06990	COG2996	Protein conserved in bacteria
FRG19_RS06995	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FRG19_RS07000	COG0573	inorganic phosphate transmembrane transporter activity
FRG19_RS07005	COG0581	inorganic phosphate transmembrane transporter activity
FRG19_RS07010	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FRG19_RS07015	COG0704	Plays a role in the regulation of phosphate uptake
FRG19_RS07020	COG1164	Oligoendopeptidase f
FRG19_RS07055	COG2348	transferase activity, transferring amino-acyl groups
FRG19_RS07060	COG2348	transferase activity, transferring amino-acyl groups
FRG19_RS07070	COG0159	tryptophan synthase activity
FRG19_RS07075	COG0133	tryptophan synthase activity
FRG19_RS07080	COG0135	phosphoribosylanthranilate isomerase activity
FRG19_RS07085	COG0134	indole-3-glycerol-phosphate synthase activity
FRG19_RS07090	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FRG19_RS07095	COG0512	Glutamine amidotransferase of anthranilate synthase
FRG19_RS07100	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FRG19_RS07105	COG1363	Peptidase, m42
FRG19_RS07110	COG0287	Prephenate dehydrogenase
FRG19_RS07115	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FRG19_RS07120	COG1942	4-Oxalocrotonate Tautomerase
FRG19_RS07135	COG0392	lysyltransferase activity
FRG19_RS07135	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FRG19_RS07140	COG0628	permease
FRG19_RS07145	COG3711	transcriptional antiterminator
FRG19_RS07150	COG1115	amino acid carrier protein
FRG19_RS07155	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FRG19_RS07160	COG0187	DNA topoisomerase II activity
FRG19_RS07165	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FRG19_RS07175	COG0824	Thioesterase
FRG19_RS07180	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FRG19_RS07185	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FRG19_RS07190	COG1970	mechanosensitive ion channel activity
FRG19_RS07195	COG0419	ATPase involved in DNA repair
FRG19_RS07200	COG0420	3'-5' exonuclease activity
FRG19_RS07205	COG4846	Membrane protein involved in cytochrome C biogenesis
FRG19_RS07235	COG0582	viral genome integration into host DNA
FRG19_RS07245	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FRG19_RS07250	COG4224	UPF0291 protein
FRG19_RS07260	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FRG19_RS07265	COG2340	Cysteine-rich secretory protein family
FRG19_RS07270	COG0516	GMP reductase activity
FRG19_RS07275	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FRG19_RS07285	COG0753	catalase activity
FRG19_RS07290	COG0833	amino acid
FRG19_RS07305	COG0083	homoserine kinase activity
FRG19_RS07310	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FRG19_RS07315	COG0460	homoserine dehydrogenase
FRG19_RS07320	COG0527	aspartate kinase activity
FRG19_RS07335	COG1525	nuclease
FRG19_RS07350	COG2197	response regulator
FRG19_RS07355	COG4585	Histidine kinase
FRG19_RS07370	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FRG19_RS07410	COG0789	Transcriptional regulator
FRG19_RS07415	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
FRG19_RS07420	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FRG19_RS07425	COG0386	Belongs to the glutathione peroxidase family
FRG19_RS07430	COG1923	regulation of RNA biosynthetic process
FRG19_RS07435	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FRG19_RS07445	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FRG19_RS07450	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FRG19_RS07455	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FRG19_RS07465	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FRG19_RS07470	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FRG19_RS07480	COG4550	Control of competence regulator ComK, YlbF/YmcA
FRG19_RS07485	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FRG19_RS07495	COG4195	phage-related replication protein
FRG19_RS07500	COG1013	pyruvate-flavodoxin oxidoreductase activity
FRG19_RS07505	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FRG19_RS07505	COG0674	pyruvate-flavodoxin oxidoreductase activity
FRG19_RS07510	COG1692	metallophosphoesterase
FRG19_RS07520	COG1418	mRNA catabolic process
FRG19_RS07525	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FRG19_RS07530	COG1546	Belongs to the CinA family
FRG19_RS07530	COG1058	Belongs to the CinA family
FRG19_RS07535	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FRG19_RS07550	COG0300	oxidoreductase activity
FRG19_RS07555	COG0612	Peptidase, M16
FRG19_RS07560	COG0612	Peptidase, M16
FRG19_RS07565	COG2188	Transcriptional regulator
FRG19_RS07570	COG1674	ftsk spoiiie
FRG19_RS07575	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FRG19_RS07580	COG1185	polyribonucleotide nucleotidyltransferase activity
FRG19_RS07585	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FRG19_RS07590	COG0196	riboflavin kinase activity
FRG19_RS07595	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FRG19_RS07600	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FRG19_RS07605	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FRG19_RS07610	COG1358	cellular component organization or biogenesis
FRG19_RS07615	COG2740	Nucleic-acid-binding protein implicated in transcription termination
FRG19_RS07620	COG0195	Participates in both transcription termination and antitermination
FRG19_RS07625	COG0779	Required for maturation of 30S ribosomal subunits
FRG19_RS07630	COG2176	DNA-directed DNA polymerase activity
FRG19_RS07635	COG0442	prolyl-tRNA aminoacylation
FRG19_RS07645	COG4589	Belongs to the CDS family
FRG19_RS07650	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FRG19_RS07655	COG0233	cytoplasmic translational termination
FRG19_RS07660	COG0528	UMP kinase activity
FRG19_RS07665	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FRG19_RS07670	COG0052	Belongs to the universal ribosomal protein uS2 family
FRG19_RS07685	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FRG19_RS07690	COG4974	Belongs to the 'phage' integrase family
FRG19_RS07695	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
FRG19_RS07700	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FRG19_RS07705	COG0758	DNA mediated transformation
FRG19_RS07710	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FRG19_RS07715	COG0045	succinate-CoA ligase (ADP-forming) activity
FRG19_RS07720	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FRG19_RS07730	COG4485	Bacterial membrane protein, YfhO
FRG19_RS07750	COG0335	large ribosomal subunit rRNA binding
FRG19_RS07755	COG0336	Belongs to the RNA methyltransferase TrmD family
FRG19_RS07760	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FRG19_RS07765	COG0228	four-way junction DNA binding
FRG19_RS07770	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FRG19_RS07775	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
FRG19_RS07780	COG0552	protein localization to endoplasmic reticulum
FRG19_RS07785	COG1196	nuclear chromosome segregation
FRG19_RS07790	COG0571	ribonuclease III activity
FRG19_RS07795	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FRG19_RS07810	COG0416	fatty acid biosynthetic process
FRG19_RS07815	COG1349	DNA-binding transcription factor activity
FRG19_RS07820	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FRG19_RS07835	COG1461	Dihydroxyacetone kinase
FRG19_RS07840	COG1302	Protein conserved in bacteria
FRG19_RS07845	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FRG19_RS07850	COG1564	THIamine pyrophosphokinase
FRG19_RS07855	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FRG19_RS07860	COG1162	GTPase activity
FRG19_RS07865	COG2807	transmembrane transport
FRG19_RS07875	COG0631	protein serine/threonine phosphatase activity
FRG19_RS07880	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FRG19_RS07885	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FRG19_RS07885	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FRG19_RS07890	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FRG19_RS07895	COG0242	peptide deformylase activity
FRG19_RS07905	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FRG19_RS07910	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FRG19_RS07915	COG1758	RNA polymerase activity
FRG19_RS07920	COG0194	GDP metabolic process
FRG19_RS07925	COG1293	RNA-binding protein homologous to eukaryotic snRNP
FRG19_RS07940	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FRG19_RS07945	COG0284	orotidine-5'-phosphate decarboxylase activity
FRG19_RS07950	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FRG19_RS07955	COG0505	Belongs to the CarA family
FRG19_RS07960	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FRG19_RS07965	COG0540	Belongs to the ATCase OTCase family
FRG19_RS07970	COG2233	PERMEase
FRG19_RS07975	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FRG19_RS07980	COG0564	pseudouridine synthase activity
FRG19_RS07985	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FRG19_RS07995	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FRG19_RS08000	COG3599	regulation of cell shape
FRG19_RS08010	COG0762	integral membrane protein
FRG19_RS08015	COG1799	cell septum assembly
FRG19_RS08020	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FRG19_RS08025	COG1496	oxidoreductase activity
FRG19_RS08030	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FRG19_RS08035	COG0849	cell division
FRG19_RS08040	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FRG19_RS08045	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FRG19_RS08050	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FRG19_RS08055	COG0768	penicillin binding
FRG19_RS08060	COG4839	cell division protein FtsL
FRG19_RS08065	COG0275	rRNA processing
FRG19_RS08075	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
FRG19_RS08080	COG0454	-acetyltransferase
FRG19_RS08085	COG1011	Hydrolase
FRG19_RS08130	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FRG19_RS08135	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FRG19_RS08140	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FRG19_RS08145	COG1053	succinate dehydrogenase
FRG19_RS08150	COG2009	succinate dehydrogenase
FRG19_RS08155	COG0322	excinuclease ABC activity
FRG19_RS08160	COG3118	belongs to the thioredoxin family
FRG19_RS08165	COG1193	negative regulation of DNA recombination
FRG19_RS08170	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FRG19_RS08170	COG1796	DNA polymerase
FRG19_RS08180	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
FRG19_RS08185	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FRG19_RS08190	COG0072	phenylalanine-tRNA ligase activity
FRG19_RS08190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FRG19_RS08195	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FRG19_RS08200	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FRG19_RS08210	COG4509	Sortase family
FRG19_RS08255	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FRG19_RS08270	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FRG19_RS08275	COG0742	ribosomal rna small subunit methyltransferase
FRG19_RS08285	COG4471	UPF0298 protein
FRG19_RS08290	COG0584	glycerophosphoryl diester phosphodiesterase
FRG19_RS08295	COG3679	Belongs to the UPF0342 family
FRG19_RS08310	COG0109	protoheme IX farnesyltransferase activity
FRG19_RS08315	COG1612	heme a metabolic process
FRG19_RS08325	COG0772	Belongs to the SEDS family
FRG19_RS08330	COG4838	Belongs to the UPF0358 family
FRG19_RS08335	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FRG19_RS08340	COG4896	Protein conserved in bacteria
FRG19_RS08345	COG1217	gtp-binding protein TYPA
FRG19_RS08355	COG0483	inositol monophosphate 1-phosphatase activity
FRG19_RS08360	COG4493	Belongs to the UPF0637 family
FRG19_RS08365	COG1914	H( )-stimulated, divalent metal cation uptake system
FRG19_RS08390	COG1176	ABC-type spermidine putrescine transport system, permease component I
FRG19_RS08405	COG4476	Belongs to the UPF0223 family
FRG19_RS08415	COG0508	dehydrogenase complex catalyzes the overall conversion of
FRG19_RS08420	COG0022	dehydrogenase e1 component
FRG19_RS08425	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FRG19_RS08435	COG0242	peptide deformylase activity
FRG19_RS08440	COG5503	Protein of unknown function (DUF1447)
FRG19_RS08445	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FRG19_RS08455	COG0569	domain protein
FRG19_RS08460	COG1294	oxidase, subunit
FRG19_RS08465	COG1271	oxidase subunit
FRG19_RS08480	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FRG19_RS08490	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FRG19_RS08510	COG4172	Belongs to the ABC transporter superfamily
FRG19_RS08515	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
FRG19_RS08520	COG0151	Belongs to the GarS family
FRG19_RS08525	COG0138	bifunctional purine biosynthesis protein purh
FRG19_RS08530	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FRG19_RS08535	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FRG19_RS08540	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FRG19_RS08545	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FRG19_RS08550	COG0047	phosphoribosylformylglycinamidine synthase activity
FRG19_RS08555	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FRG19_RS08560	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FRG19_RS08565	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FRG19_RS08570	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FRG19_RS08575	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FRG19_RS08580	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FRG19_RS08580	COG1017	nitric oxide dioxygenase activity
FRG19_RS08590	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FRG19_RS08595	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FRG19_RS08605	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FRG19_RS08620	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FRG19_RS08625	COG1316	TRANSCRIPTIONal
FRG19_RS08650	COG3594	Acyltransferase
FRG19_RS08655	COG0436	Aminotransferase
FRG19_RS08660	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FRG19_RS08670	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FRG19_RS08675	COG1169	isochorismate synthase
FRG19_RS08680	COG1575	Belongs to the MenA family. Type 1 subfamily
FRG19_RS08750	COG4873	Protein conserved in bacteria
FRG19_RS08760	COG0737	Belongs to the 5'-nucleotidase family
FRG19_RS08765	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FRG19_RS08770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FRG19_RS08775	COG0861	Integral membrane protein TerC family
FRG19_RS08780	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FRG19_RS08790	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FRG19_RS08795	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FRG19_RS08800	COG2814	Major facilitator Superfamily
FRG19_RS08805	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
FRG19_RS08810	COG2382	esterase
FRG19_RS08815	COG0628	permease
FRG19_RS08825	COG0569	domain protein
FRG19_RS08825	COG0475	glutathione-regulated potassium exporter activity
FRG19_RS08830	COG2239	Acts as a magnesium transporter
FRG19_RS08835	COG0564	pseudouridine synthase activity
FRG19_RS08840	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FRG19_RS08845	COG2357	RelA SpoT domain protein
FRG19_RS08855	COG4116	CYTH
FRG19_RS08860	COG2346	COG2346, Truncated hemoglobins
FRG19_RS08865	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FRG19_RS08870	COG1164	Oligoendopeptidase f
FRG19_RS08880	COG4862	establishment of competence for transformation
FRG19_RS08885	COG1393	Belongs to the ArsC family
FRG19_RS08890	COG0180	Tryptophanyl-tRNA synthetase
FRG19_RS08895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FRG19_RS08900	COG0601	transmembrane transport
FRG19_RS08905	COG4608	Belongs to the ABC transporter superfamily
FRG19_RS08910	COG0444	Belongs to the ABC transporter superfamily
FRG19_RS08915	COG0747	negative chemotaxis
FRG19_RS08925	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FRG19_RS08935	COG1881	PFAM PEBP family protein
FRG19_RS08940	COG0542	response to heat
FRG19_RS08955	COG0561	phosphatase activity
FRG19_RS08960	COG0446	pyridine nucleotide-disulphide oxidoreductase
FRG19_RS08970	COG0179	Fumarylacetoacetate (FAA) hydrolase
FRG19_RS08975	COG1074	ATP-dependent DNA helicase activity
FRG19_RS08980	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
FRG19_RS08995	COG0398	Pfam SNARE associated Golgi protein
FRG19_RS09000	COG0166	Belongs to the GPI family
FRG19_RS09005	COG0137	argininosuccinate synthase activity
FRG19_RS09010	COG0165	Argininosuccinate lyase
FRG19_RS09015	COG0584	glycerophosphoryl diester phosphodiesterase
FRG19_RS09030	COG1902	pentaerythritol trinitrate reductase activity
FRG19_RS09035	COG1098	S1 RNA binding domain
FRG19_RS09040	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FRG19_RS09050	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FRG19_RS09050	COG2111	Na H antiporter
FRG19_RS09055	COG2111	Na H antiporter
FRG19_RS09060	COG1006	Multisubunit Na H antiporter MnhC subunit
FRG19_RS09065	COG0651	ATP synthesis coupled electron transport
FRG19_RS09070	COG1863	multisubunit Na H antiporter MnhE subunit
FRG19_RS09075	COG2212	antiporter activity
FRG19_RS09080	COG1320	monovalent cation:proton antiporter activity
FRG19_RS09090	COG2050	protein possibly involved in aromatic compounds catabolism
FRG19_RS09095	COG2056	Na+-H+ antiporter family
FRG19_RS09100	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FRG19_RS09105	COG1252	NADH dehydrogenase
FRG19_RS09110	COG0316	Belongs to the HesB IscA family
FRG19_RS09115	COG4844	belongs to the
FRG19_RS09120	COG1252	NADH dehydrogenase
FRG19_RS09125	COG4837	Protein of unknown function (DUF1462)
FRG19_RS09130	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FRG19_RS09135	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
FRG19_RS09145	COG1696	Membrane protein involved in D-alanine export
FRG19_RS09150	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FRG19_RS09160	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FRG19_RS09165	COG0647	UMP catabolic process
FRG19_RS09170	COG2445	Protein of unknown function DUF86
FRG19_RS09180	COG4470	Protein conserved in bacteria
FRG19_RS09185	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FRG19_RS09190	COG0737	Belongs to the 5'-nucleotidase family
FRG19_RS09195	COG0730	response to heat
FRG19_RS09200	COG1801	Protein of unknown function DUF72
FRG19_RS09205	COG2070	2-Nitropropane dioxygenase
FRG19_RS09210	COG1253	flavin adenine dinucleotide binding
FRG19_RS09215	COG0719	Fe-S assembly protein
FRG19_RS09220	COG0822	iron-sulfur transferase activity
FRG19_RS09225	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FRG19_RS09230	COG0719	Fe-S assembly protein
FRG19_RS09235	COG0396	ATPase activity
FRG19_RS09255	COG1464	Belongs to the NlpA lipoprotein family
FRG19_RS09260	COG2011	ABC-type metal ion transport system permease component
FRG19_RS09265	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FRG19_RS09275	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
FRG19_RS09280	COG0509	glycine decarboxylation via glycine cleavage system
FRG19_RS09285	COG1393	Belongs to the ArsC family
FRG19_RS09290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FRG19_RS09300	COG0710	3-dehydroquinate dehydratase activity
FRG19_RS09305	COG1764	response to oxidative stress
FRG19_RS09315	COG1279	arginine transmembrane transporter activity
FRG19_RS09320	COG0406	alpha-ribazole phosphatase activity
FRG19_RS09355	COG4195	phage-related replication protein
FRG19_RS09375	COG1278	Cold shock
FRG19_RS09390	COG0519	Catalyzes the synthesis of GMP from XMP
FRG19_RS09400	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FRG19_RS09480	COG3655	Transcriptional regulator
FRG19_RS09485	COG0582	viral genome integration into host DNA
FRG19_RS09495	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FRG19_RS09500	COG0557	exoribonuclease II activity
FRG19_RS09505	COG1647	Serine aminopeptidase, S33
FRG19_RS09510	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FRG19_RS09520	COG0148	phosphopyruvate hydratase activity
FRG19_RS09525	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FRG19_RS09530	COG0149	triose-phosphate isomerase activity
FRG19_RS09535	COG0126	phosphoglycerate kinase activity
FRG19_RS09540	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FRG19_RS09545	COG2390	Transcriptional regulator
FRG19_RS09560	COG1090	epimerase
FRG19_RS09580	COG1481	regulation of sporulation
FRG19_RS09585	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FRG19_RS09590	COG1660	Displays ATPase and GTPase activities
FRG19_RS09595	COG0492	ferredoxin-NADP+ reductase activity
FRG19_RS09610	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FRG19_RS09615	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
FRG19_RS09620	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FRG19_RS09625	COG0556	nucleotide-excision repair
FRG19_RS09640	COG1388	LysM domain
FRG19_RS09640	COG3942	CHAP domain
FRG19_RS09650	COG0653	protein targeting
FRG19_RS09660	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FRG19_RS09670	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
FRG19_RS09680	COG1739	Uncharacterized protein family UPF0029
FRG19_RS09685	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FRG19_RS09705	COG2195	Cleaves the N-terminal amino acid of tripeptides
FRG19_RS09710	COG1929	Belongs to the glycerate kinase type-1 family
FRG19_RS09730	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FRG19_RS09740	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FRG19_RS09745	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FRG19_RS09750	COG1780	Probably involved in ribonucleotide reductase function
FRG19_RS09765	COG3104	oligopeptide transport
FRG19_RS09770	COG1597	lipid kinase activity
FRG19_RS09780	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FRG19_RS09785	COG1174	glycine betaine transport
FRG19_RS09795	COG0514	ATP-dependent DNA helicase (RecQ)
FRG19_RS09800	COG0488	(ABC) transporter
FRG19_RS09810	COG1368	sulfuric ester hydrolase activity
FRG19_RS09820	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FRG19_RS09835	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FRG19_RS09845	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FRG19_RS09850	COG0720	synthase
FRG19_RS09855	COG0602	queuosine metabolic process
FRG19_RS09875	COG0745	RESPONSE REGULATOR receiver
FRG19_RS09880	COG5002	protein histidine kinase activity
FRG19_RS09885	COG0463	Glycosyl transferase, family 2
FRG19_RS09890	COG0656	L-ascorbic acid biosynthetic process
FRG19_RS09895	COG1253	flavin adenine dinucleotide binding
FRG19_RS09900	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FRG19_RS09905	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FRG19_RS09905	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FRG19_RS09905	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FRG19_RS09910	COG1105	Belongs to the carbohydrate kinase PfkB family
FRG19_RS09915	COG1349	DNA-binding transcription factor activity
FRG19_RS09920	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FRG19_RS09945	COG0415	Belongs to the DNA photolyase family
FRG19_RS09950	COG0471	metal ion transport
FRG19_RS09955	COG0039	L-malate dehydrogenase activity
FRG19_RS09975	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FRG19_RS09980	COG4988	ABC transporter
FRG19_RS09985	COG1968	undecaprenyl-diphosphatase activity
FRG19_RS09995	COG1671	Belongs to the UPF0178 family
FRG19_RS10000	COG1611	Belongs to the LOG family
FRG19_RS10010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FRG19_RS10035	COG2839	Protein conserved in bacteria
FRG19_RS10045	COG0583	DNA-binding transcription factor activity
FRG19_RS10060	COG0217	transcriptional regulatory protein
FRG19_RS10070	COG1917	Cupin 2, conserved barrel domain protein
FRG19_RS10070	COG4977	sequence-specific DNA binding
FRG19_RS10080	COG1388	LysM domain
FRG19_RS10080	COG3942	CHAP domain
FRG19_RS10085	COG0306	phosphate transporter
FRG19_RS10090	COG1392	Phosphate transport regulator
FRG19_RS10095	COG0577	efflux transmembrane transporter activity
FRG19_RS10100	COG1136	(ABC) transporter
FRG19_RS10105	COG2205	protein histidine kinase activity
FRG19_RS10110	COG0745	RESPONSE REGULATOR receiver
FRG19_RS10115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FRG19_RS10125	COG0657	acetylesterase activity
FRG19_RS10130	COG3949	Membrane
FRG19_RS10140	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
FRG19_RS10150	COG2376	Dihydroxyacetone kinase
FRG19_RS10155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FRG19_RS10160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FRG19_RS10165	COG1120	ATPase activity
FRG19_RS10170	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FRG19_RS10175	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FRG19_RS10180	COG1132	(ABC) transporter
FRG19_RS10185	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FRG19_RS10195	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FRG19_RS10200	COG1682	transport, permease protein
FRG19_RS10205	COG1134	teichoic acid transport
FRG19_RS10210	COG5609	conserved protein (DUF2294)
FRG19_RS10220	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
FRG19_RS10230	COG1321	iron dependent repressor
FRG19_RS10235	COG1121	(ABC) transporter
FRG19_RS10240	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FRG19_RS10245	COG0803	Belongs to the bacterial solute-binding protein 9 family
FRG19_RS10255	COG1320	monovalent cation:proton antiporter activity
FRG19_RS10260	COG2212	antiporter activity
FRG19_RS10265	COG1863	multisubunit Na H antiporter MnhE subunit
FRG19_RS10270	COG0651	ATP synthesis coupled electron transport
FRG19_RS10275	COG1006	Multisubunit Na H antiporter MnhC subunit
FRG19_RS10280	COG2111	Na H antiporter
FRG19_RS10285	COG2111	Na H antiporter
FRG19_RS10285	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FRG19_RS10320	COG0596	Alpha beta hydrolase
FRG19_RS10345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FRG19_RS10350	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FRG19_RS10365	COG0789	Transcriptional regulator
FRG19_RS10370	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FRG19_RS10375	COG0018	arginyl-trna synthetase
FRG19_RS10390	COG3875	lactate racemase activity
FRG19_RS10395	COG1606	tRNA processing
FRG19_RS10400	COG1691	(AIR) carboxylase
FRG19_RS10405	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
FRG19_RS10420	COG1078	dGTPase activity
FRG19_RS10430	COG0655	NAD(P)H dehydrogenase (quinone) activity
FRG19_RS10435	COG0667	Aldo Keto reductase
FRG19_RS10445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FRG19_RS10450	COG4844	belongs to the
FRG19_RS10470	COG0095	Lipoate-protein ligase
FRG19_RS10475	COG0280	phosphate acetyltransferase
FRG19_RS10480	COG3253	May function as heme-dependent peroxidase
FRG19_RS10500	COG2363	Small membrane protein
FRG19_RS10510	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FRG19_RS10515	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
FRG19_RS10520	COG0351	phosphomethylpyrimidine kinase
FRG19_RS10550	COG0183	Belongs to the thiolase family
FRG19_RS10555	COG0318	PFAM AMP-dependent synthetase and ligase
FRG19_RS10570	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
FRG19_RS10575	COG0363	glucosamine-6-phosphate deaminase activity
FRG19_RS10580	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FRG19_RS10585	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FRG19_RS10600	COG0438	transferase activity, transferring glycosyl groups
FRG19_RS10605	COG0431	NADPH-dependent FMN reductase
FRG19_RS10610	COG0561	phosphatase activity
FRG19_RS10620	COG1428	Deoxynucleoside kinase
FRG19_RS10625	COG1428	Deoxynucleoside kinase
FRG19_RS10635	COG0546	phosphoglycolate phosphatase activity
FRG19_RS10640	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FRG19_RS10650	COG0737	Belongs to the 5'-nucleotidase family
FRG19_RS10675	COG1473	amidohydrolase
FRG19_RS10680	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FRG19_RS10685	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FRG19_RS10695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FRG19_RS10705	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FRG19_RS10710	COG0085	RNA polymerase activity
FRG19_RS10715	COG2813	Specifically methylates the guanine in position
FRG19_RS10720	COG0222	ribosome binding
FRG19_RS10725	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FRG19_RS10730	COG0081	regulation of translation
FRG19_RS10735	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FRG19_RS10740	COG0250	Participates in transcription elongation, termination and antitermination
FRG19_RS10745	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FRG19_RS10750	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FRG19_RS10760	COG3688	RNA-binding protein containing a PIN domain
FRG19_RS10770	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
FRG19_RS10775	COG0215	cysteine-tRNA ligase activity
FRG19_RS10780	COG1045	serine acetyltransferase
FRG19_RS10785	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FRG19_RS10790	COG4956	integral membrane protein (PIN domain superfamily)
FRG19_RS10795	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FRG19_RS10800	COG0542	response to heat
FRG19_RS10805	COG3869	Catalyzes the specific phosphorylation of arginine residues in
FRG19_RS10810	COG3880	PFAM UvrB UvrC protein
FRG19_RS10815	COG4463	regulation of RNA biosynthetic process
FRG19_RS10820	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FRG19_RS10825	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
FRG19_RS10830	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
FRG19_RS10835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FRG19_RS10920	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FRG19_RS10925	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FRG19_RS10930	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FRG19_RS10940	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FRG19_RS10945	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FRG19_RS10950	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FRG19_RS10955	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
FRG19_RS10960	COG0037	tRNA processing
FRG19_RS10965	COG1098	S1 RNA binding domain
FRG19_RS10975	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FRG19_RS10980	COG3956	TIGRFAM MazG family protein
FRG19_RS10985	COG2244	polysaccharide biosynthetic process
FRG19_RS10990	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FRG19_RS11000	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FRG19_RS11005	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FRG19_RS11010	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FRG19_RS11015	COG2088	sporulation resulting in formation of a cellular spore
FRG19_RS11020	COG0251	oxidation-reduction process
FRG19_RS11025	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FRG19_RS11030	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FRG19_RS11035	COG4466	Protein conserved in bacteria
FRG19_RS11040	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FRG19_RS11045	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
FRG19_RS11050	COG0084	hydrolase, TatD family'
FRG19_RS11055	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FRG19_RS11055	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FRG19_RS11060	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FRG19_RS11065	COG2827	Endonuclease containing a URI domain
FRG19_RS11070	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FRG19_RS11075	COG4467	Involved in initiation control of chromosome replication
FRG19_RS11080	COG1774	PSP1 C-terminal conserved region
FRG19_RS11085	COG0470	DNA polymerase III
FRG19_RS11090	COG3870	Protein conserved in bacteria
FRG19_RS11095	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FRG19_RS11100	COG1982	Orn Lys Arg decarboxylase major
FRG19_RS11125	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FRG19_RS11130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FRG19_RS11135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FRG19_RS11155	COG0493	'glutamate synthase
FRG19_RS11160	COG0070	glutamate synthase
FRG19_RS11160	COG0067	glutamate synthase
FRG19_RS11160	COG0069	glutamate synthase activity
FRG19_RS11165	COG0583	DNA-binding transcription factor activity
FRG19_RS11195	COG0438	transferase activity, transferring glycosyl groups
FRG19_RS11200	COG1388	LysM domain
FRG19_RS11200	COG3942	CHAP domain
FRG19_RS11210	COG2011	ABC-type metal ion transport system permease component
FRG19_RS11215	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FRG19_RS11225	COG0626	cystathionine gamma-synthase activity
FRG19_RS11230	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FRG19_RS11245	COG0733	neurotransmitter:sodium symporter activity
FRG19_RS11255	COG1647	Serine aminopeptidase, S33
FRG19_RS11280	COG5609	conserved protein (DUF2294)
FRG19_RS11285	COG3002	Belongs to the UPF0753 family
FRG19_RS11290	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FRG19_RS11320	COG0523	cobalamin synthesis protein
FRG19_RS11330	COG2211	Major facilitator Superfamily
FRG19_RS11340	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
FRG19_RS11355	COG0519	Catalyzes the synthesis of GMP from XMP
FRG19_RS11355	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FRG19_RS11360	COG0516	GMP reductase activity
FRG19_RS11360	COG0517	IMP dehydrogenase activity
FRG19_RS11365	COG2233	PERMEase
FRG19_RS11370	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FRG19_RS11385	COG5183	chlorophyll binding
FRG19_RS11390	COG1823	symporter activity
FRG19_RS11395	COG0778	Nitroreductase
FRG19_RS11405	COG0450	alkyl hydroperoxide reductase
FRG19_RS11410	COG3634	alkyl hydroperoxide reductase activity
FRG19_RS11430	COG1280	lysine exporter protein (LysE YggA)
FRG19_RS11475	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FRG19_RS11485	COG0360	Binds together with S18 to 16S ribosomal RNA
FRG19_RS11495	COG1011	Hydrolase
FRG19_RS11520	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FRG19_RS11540	COG0012	GTP binding
FRG19_RS11545	COG4481	Protein conserved in bacteria
FRG19_RS11550	COG0668	transmembrane transport
FRG19_RS11555	COG1475	DNA binding
FRG19_RS11560	COG0626	cystathionine gamma-synthase activity
FRG19_RS11565	COG0626	cystathionine gamma-synthase activity
FRG19_RS11570	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FRG19_RS11570	COG0646	methionine synthase
FRG19_RS11575	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FRG19_RS11585	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FRG19_RS11590	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FRG19_RS11595	COG0183	Belongs to the thiolase family
FRG19_RS11600	COG0346	lactoylglutathione lyase activity
FRG19_RS11615	COG1476	TRANSCRIPTIONal
FRG19_RS11625	COG1131	(ABC) transporter
FRG19_RS11635	COG2814	Major facilitator Superfamily
FRG19_RS11675	COG1136	(ABC) transporter
FRG19_RS11680	COG0577	efflux transmembrane transporter activity
FRG19_RS11710	COG0577	efflux transmembrane transporter activity
FRG19_RS11715	COG1136	(ABC) transporter
FRG19_RS11720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FRG19_RS11755	COG0300	oxidoreductase activity
FRG19_RS11760	COG1475	DNA binding
FRG19_RS11765	COG0357	Ribosomal RNA small subunit methyltransferase G
FRG19_RS11770	COG0445	tRNA wobble uridine modification
FRG19_RS11775	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FRG19_RS11780	COG0594	ribonuclease P activity
FRG19_RS11860	COG3620	sequence-specific DNA binding
FRG19_RS11915	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FRG19_RS11930	COG1131	(ABC) transporter
FRG19_RS11965	COG0579	oxidoreductase
FRG19_RS11970	COG1620	l-lactate permease
FRG19_RS11975	COG3527	Alpha-acetolactate decarboxylase
FRG19_RS11980	COG0028	Belongs to the TPP enzyme family
FRG19_RS11985	COG1278	Cold shock
FRG19_RS12020	COG1192	Involved in chromosome partitioning
FRG19_RS12070	COG1131	(ABC) transporter
FRG19_RS12085	COG0706	membrane insertase activity
FRG19_RS12160	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
FRG19_RS12165	COG1733	regulation of RNA biosynthetic process
FRG19_RS12175	COG1063	alcohol dehydrogenase
FRG19_RS12180	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate