locus-tag	class	description
FOC61_RS00005	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FOC61_RS00015	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FOC61_RS00020	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FOC61_RS00025	COG0183	Belongs to the thiolase family
FOC61_RS00030	COG0346	lactoylglutathione lyase activity
FOC61_RS00045	COG1476	TRANSCRIPTIONal
FOC61_RS00055	COG1131	(ABC) transporter
FOC61_RS00065	COG2814	Major facilitator Superfamily
FOC61_RS00105	COG1136	(ABC) transporter
FOC61_RS00110	COG0577	efflux transmembrane transporter activity
FOC61_RS00145	COG0577	efflux transmembrane transporter activity
FOC61_RS00150	COG1136	(ABC) transporter
FOC61_RS00155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FOC61_RS00190	COG0300	oxidoreductase activity
FOC61_RS00195	COG1475	DNA binding
FOC61_RS00200	COG0357	Ribosomal RNA small subunit methyltransferase G
FOC61_RS00205	COG0445	tRNA wobble uridine modification
FOC61_RS00210	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FOC61_RS00215	COG0594	ribonuclease P activity
FOC61_RS00225	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FOC61_RS00230	COG0592	DNA-directed DNA polymerase activity
FOC61_RS00235	COG2501	S4 domain
FOC61_RS00240	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FOC61_RS00245	COG0187	DNA topoisomerase II activity
FOC61_RS00250	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FOC61_RS00255	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FOC61_RS00265	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FOC61_RS00280	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FOC61_RS00290	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
FOC61_RS00295	COG0359	binds to the 23S rRNA
FOC61_RS00300	COG0305	Participates in initiation and elongation during chromosome replication
FOC61_RS00305	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FOC61_RS00320	COG0745	RESPONSE REGULATOR receiver
FOC61_RS00325	COG5002	protein histidine kinase activity
FOC61_RS00330	COG4863	YycH protein
FOC61_RS00340	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FOC61_RS00345	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FOC61_RS00350	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FOC61_RS00365	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FOC61_RS00460	COG1309	transcriptional regulator
FOC61_RS00470	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FOC61_RS00475	COG1755	Isoprenylcysteine carboxyl methyltransferase
FOC61_RS00480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FOC61_RS00490	COG1136	(ABC) transporter
FOC61_RS00525	COG0745	RESPONSE REGULATOR receiver
FOC61_RS00530	COG2205	protein histidine kinase activity
FOC61_RS00535	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FOC61_RS00540	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FOC61_RS00570	COG0601	transmembrane transport
FOC61_RS00580	COG0444	Belongs to the ABC transporter superfamily
FOC61_RS00610	COG3246	L-lysine catabolic process to acetate
FOC61_RS00615	COG1250	3-hydroxyacyl-CoA dehydrogenase
FOC61_RS00640	COG1174	glycine betaine transport
FOC61_RS00655	COG1114	Component of the transport system for branched-chain amino acids
FOC61_RS00660	COG1288	antiporter activity
FOC61_RS00665	COG0549	Belongs to the carbamate kinase family
FOC61_RS00685	COG2814	Major facilitator Superfamily
FOC61_RS00705	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FOC61_RS00730	COG2814	Major facilitator Superfamily
FOC61_RS00740	COG1028	Short-chain dehydrogenase reductase Sdr
FOC61_RS00790	COG2814	Major facilitator Superfamily
FOC61_RS00795	COG0583	DNA-binding transcription factor activity
FOC61_RS00800	COG2318	DinB family
FOC61_RS00805	COG2311	Membrane
FOC61_RS00810	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
FOC61_RS00820	COG0471	metal ion transport
FOC61_RS00825	COG1733	regulation of RNA biosynthetic process
FOC61_RS00830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FOC61_RS00855	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
FOC61_RS00865	COG3386	PFAM SMP-30 Gluconolaconase
FOC61_RS00870	COG2353	YceI-like domain
FOC61_RS00880	COG0579	oxidoreductase
FOC61_RS00900	COG0693	protein deglycase activity
FOC61_RS00910	COG1686	Belongs to the peptidase S11 family
FOC61_RS00945	COG0726	polysaccharide deacetylase
FOC61_RS00975	COG2814	Major facilitator Superfamily
FOC61_RS00985	COG0737	Belongs to the 5'-nucleotidase family
FOC61_RS01000	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
FOC61_RS01005	COG3639	organic phosphonate transmembrane transporter activity
FOC61_RS01015	COG0702	epimerase
FOC61_RS01045	COG1073	alpha beta
FOC61_RS01055	COG0653	protein targeting
FOC61_RS01065	COG0438	transferase activity, transferring glycosyl groups
FOC61_RS01100	COG2814	Major facilitator Superfamily
FOC61_RS01105	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FOC61_RS01110	COG0604	alcohol dehydrogenase
FOC61_RS01125	COG2113	Glycine betaine
FOC61_RS01130	COG2409	Drug exporters of the RND superfamily
FOC61_RS01145	COG0583	DNA-binding transcription factor activity
FOC61_RS01155	COG1840	ABC-type Fe3 transport system, periplasmic component
FOC61_RS01165	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FOC61_RS01170	COG1764	response to oxidative stress
FOC61_RS01185	COG3942	CHAP domain
FOC61_RS01185	COG1705	Flagellar rod assembly protein muramidase FlgJ
FOC61_RS01195	COG1482	cell wall glycoprotein biosynthetic process
FOC61_RS01200	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FOC61_RS01200	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FOC61_RS01200	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FOC61_RS01205	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FOC61_RS01205	COG3711	transcriptional antiterminator
FOC61_RS01210	COG0540	Belongs to the ATCase OTCase family
FOC61_RS01220	COG0640	Transcriptional regulator
FOC61_RS01225	COG2814	Major facilitator Superfamily
FOC61_RS01245	COG0732	type I restriction modification DNA specificity domain
FOC61_RS01290	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FOC61_RS01340	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FOC61_RS01375	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FOC61_RS01380	COG3961	Belongs to the TPP enzyme family
FOC61_RS01385	COG1846	Transcriptional regulator
FOC61_RS01400	COG4195	phage-related replication protein
FOC61_RS01405	COG4195	phage-related replication protein
FOC61_RS01410	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FOC61_RS01425	COG1785	Belongs to the alkaline phosphatase family
FOC61_RS01435	COG0745	RESPONSE REGULATOR receiver
FOC61_RS01440	COG2205	protein histidine kinase activity
FOC61_RS01445	COG1136	(ABC) transporter
FOC61_RS01460	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FOC61_RS01480	COG0386	Belongs to the glutathione peroxidase family
FOC61_RS01485	COG0175	sulfate reduction
FOC61_RS01490	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FOC61_RS01510	COG0730	response to heat
FOC61_RS01515	COG2046	Belongs to the sulfate adenylyltransferase family
FOC61_RS01520	COG0529	Catalyzes the synthesis of activated sulfate
FOC61_RS01525	COG2851	Citrate transporter
FOC61_RS01540	COG1328	CTP reductase activity
FOC61_RS01545	COG0602	queuosine metabolic process
FOC61_RS01550	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FOC61_RS01560	COG1510	regulation of RNA biosynthetic process
FOC61_RS01565	COG1012	belongs to the aldehyde dehydrogenase family
FOC61_RS01570	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
FOC61_RS01575	COG1473	amidohydrolase
FOC61_RS01595	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FOC61_RS01600	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FOC61_RS01600	COG0574	Belongs to the PEP-utilizing enzyme family
FOC61_RS01605	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FOC61_RS01610	COG0579	oxidoreductase
FOC61_RS01630	COG3588	fructose-bisphosphate aldolase
FOC61_RS01635	COG0446	pyridine nucleotide-disulphide oxidoreductase
FOC61_RS01670	COG0583	DNA-binding transcription factor activity
FOC61_RS01675	COG0039	L-malate dehydrogenase activity
FOC61_RS01680	COG0028	Belongs to the TPP enzyme family
FOC61_RS01685	COG3527	Alpha-acetolactate decarboxylase
FOC61_RS01695	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FOC61_RS01700	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FOC61_RS01715	COG4640	response to antibiotic
FOC61_RS01740	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FOC61_RS01750	COG0167	dihydroorotate dehydrogenase activity
FOC61_RS01755	COG3001	Fructosamine kinase
FOC61_RS01770	COG0596	Alpha beta hydrolase
FOC61_RS01780	COG1028	Short-chain dehydrogenase reductase Sdr
FOC61_RS01805	COG1113	amino acid transport
FOC61_RS01825	COG0741	lytic transglycosylase activity
FOC61_RS01835	COG1233	COG1233 Phytoene dehydrogenase and related
FOC61_RS01870	COG2608	mercury ion transmembrane transporter activity
FOC61_RS01875	COG2217	Heavy metal translocating P-type atpase
FOC61_RS01885	COG1028	Short-chain dehydrogenase reductase Sdr
FOC61_RS01930	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FOC61_RS01935	COG3425	synthase
FOC61_RS01955	COG0583	DNA-binding transcription factor activity
FOC61_RS01960	COG1380	Effector of murein hydrolase LrgA
FOC61_RS01965	COG1346	cytolysis
FOC61_RS01970	COG0028	Belongs to the TPP enzyme family
FOC61_RS01980	COG1266	CAAX protease self-immunity
FOC61_RS01995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FOC61_RS02000	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FOC61_RS02010	COG0697	spore germination
FOC61_RS02025	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FOC61_RS02035	COG2843	Capsule synthesis protein
FOC61_RS02050	COG4975	Glucose uptake
FOC61_RS02055	COG1869	D-ribose catabolic process
FOC61_RS02065	COG1070	Carbohydrate kinase
FOC61_RS02080	COG1760	l-serine dehydratase
FOC61_RS02085	COG1760	l-serine dehydratase
FOC61_RS02095	COG1247	-acetyltransferase
FOC61_RS02100	COG3764	Sortase (surface protein transpeptidase)
FOC61_RS02105	COG0561	phosphatase activity
FOC61_RS02115	COG0778	Nitroreductase
FOC61_RS02120	COG1012	belongs to the aldehyde dehydrogenase family
FOC61_RS02145	COG3949	Membrane
FOC61_RS02155	COG1476	TRANSCRIPTIONal
FOC61_RS02165	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
FOC61_RS02170	COG0586	Pfam SNARE associated Golgi protein
FOC61_RS02180	COG2022	thiamine diphosphate biosynthetic process
FOC61_RS02190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FOC61_RS02215	COG4876	unkown
FOC61_RS02220	COG2357	RelA SpoT domain protein
FOC61_RS02230	COG1802	Transcriptional regulator
FOC61_RS02235	COG1070	Carbohydrate kinase
FOC61_RS02240	COG2610	gluconate transmembrane transporter activity
FOC61_RS02245	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FOC61_RS02270	COG4221	oxidoreductase activity
FOC61_RS02275	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FOC61_RS02280	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FOC61_RS02290	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FOC61_RS02295	COG1028	Short-chain dehydrogenase reductase Sdr
FOC61_RS02305	COG1363	Peptidase, m42
FOC61_RS02310	COG4808	Protein conserved in bacteria
FOC61_RS02315	COG0069	glutamate synthase activity
FOC61_RS02330	COG4619	ABC transporter
FOC61_RS02335	COG0390	transport system, permease component
FOC61_RS02340	COG2814	Major facilitator Superfamily
FOC61_RS02345	COG2272	Belongs to the type-B carboxylesterase lipase family
FOC61_RS02350	COG0531	amino acid
FOC61_RS02355	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
FOC61_RS02360	COG1063	alcohol dehydrogenase
FOC61_RS02380	COG1174	glycine betaine transport
FOC61_RS02385	COG1346	cytolysis
FOC61_RS02390	COG1380	Effector of murein hydrolase LrgA
FOC61_RS02400	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FOC61_RS02415	COG0706	membrane insertase activity
FOC61_RS02435	COG1113	amino acid transport
FOC61_RS02455	COG2814	Major facilitator Superfamily
FOC61_RS02465	COG1929	Belongs to the glycerate kinase type-1 family
FOC61_RS02480	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FOC61_RS02485	COG0741	lytic transglycosylase activity
FOC61_RS02490	COG0588	phosphoglycerate mutase activity
FOC61_RS02500	COG2814	Major facilitator Superfamily
FOC61_RS02505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FOC61_RS02510	COG0765	amino acid transport
FOC61_RS02515	COG1126	abc transporter atp-binding protein
FOC61_RS02525	COG2348	transferase activity, transferring amino-acyl groups
FOC61_RS02560	COG0454	-acetyltransferase
FOC61_RS02565	COG0747	negative chemotaxis
FOC61_RS02575	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FOC61_RS02580	COG2146	nitrite reductase [NAD(P)H] activity
FOC61_RS02590	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
FOC61_RS02595	COG1140	nitrate reductase beta subunit
FOC61_RS02605	COG2181	nitrate reductase activity
FOC61_RS02615	COG4585	Histidine kinase
FOC61_RS02620	COG2197	response regulator
FOC61_RS02625	COG2223	nitrite transmembrane transporter activity
FOC61_RS02640	COG0778	Nitroreductase
FOC61_RS02660	COG3871	stress protein (general stress protein 26)
FOC61_RS02675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FOC61_RS02675	COG1263	PTS System
FOC61_RS02710	COG0492	ferredoxin-NADP+ reductase activity
FOC61_RS02720	COG0604	alcohol dehydrogenase
FOC61_RS02725	COG2822	iron ion transport
FOC61_RS02730	COG2837	iron assimilation
FOC61_RS02740	COG0805	protein transport
FOC61_RS02745	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FOC61_RS02755	COG0463	Glycosyl transferase, family 2
FOC61_RS02755	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FOC61_RS02765	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FOC61_RS02770	COG1620	l-lactate permease
FOC61_RS02780	COG0579	oxidoreductase
FOC61_RS02785	COG3850	Histidine kinase
FOC61_RS02785	COG5002	protein histidine kinase activity
FOC61_RS02790	COG0745	RESPONSE REGULATOR receiver
FOC61_RS02795	COG0577	efflux transmembrane transporter activity
FOC61_RS02800	COG1136	(ABC) transporter
FOC61_RS02815	COG4640	response to antibiotic
FOC61_RS02820	COG2814	Major facilitator Superfamily
FOC61_RS02830	COG1566	PFAM secretion protein HlyD family protein
FOC61_RS02835	COG2814	Major facilitator Superfamily
FOC61_RS02860	COG0598	Magnesium transport protein CorA
FOC61_RS02865	COG1304	FMN binding
FOC61_RS02870	COG0786	glutamate:sodium symporter activity
FOC61_RS02890	COG2094	Belongs to the DNA glycosylase MPG family
FOC61_RS02895	COG3152	Membrane
FOC61_RS02910	COG1069	ribulokinase activity
FOC61_RS02915	COG4152	abc transporter atp-binding protein
FOC61_RS02920	COG1668	transmembrane transport
FOC61_RS02925	COG1742	UPF0060 membrane protein
FOC61_RS02935	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FOC61_RS02940	COG1266	CAAX protease self-immunity
FOC61_RS02945	COG0010	Belongs to the arginase family
FOC61_RS02950	COG0583	DNA-binding transcription factor activity
FOC61_RS02965	COG0659	secondary active sulfate transmembrane transporter activity
FOC61_RS02975	COG1028	Short-chain dehydrogenase reductase Sdr
FOC61_RS03000	COG1737	Transcriptional regulator
FOC61_RS03015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FOC61_RS03035	COG1113	amino acid transport
FOC61_RS03045	COG1263	PTS System
FOC61_RS03045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FOC61_RS03050	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FOC61_RS03080	COG1316	TRANSCRIPTIONal
FOC61_RS03110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FOC61_RS03115	COG2076	Multidrug Resistance protein
FOC61_RS03120	COG2076	Multidrug Resistance protein
FOC61_RS03125	COG3942	CHAP domain
FOC61_RS03140	COG1757	Na H antiporter
FOC61_RS03145	COG3942	CHAP domain
FOC61_RS03185	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
FOC61_RS03190	COG0804	urea catabolic process
FOC61_RS03195	COG0832	Belongs to the urease beta subunit family
FOC61_RS03200	COG0831	urea catabolic process
FOC61_RS03205	COG4413	Urea transporter
FOC61_RS03210	COG1960	acyl-CoA dehydrogenase activity
FOC61_RS03215	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FOC61_RS03225	COG1268	BioY protein
FOC61_RS03240	COG0725	ABC transporter, periplasmic molybdate-binding protein
FOC61_RS03245	COG4149	molybdate abc transporter
FOC61_RS03250	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FOC61_RS03255	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FOC61_RS03260	COG0521	Mo-molybdopterin cofactor biosynthetic process
FOC61_RS03265	COG0315	cyclic pyranopterin monophosphate synthase activity
FOC61_RS03270	COG0303	'Molybdopterin
FOC61_RS03275	COG1763	Mo-molybdopterin cofactor biosynthetic process
FOC61_RS03290	COG0746	molybdenum cofactor guanylyltransferase activity
FOC61_RS03305	COG2814	Major facilitator Superfamily
FOC61_RS03325	COG2348	transferase activity, transferring amino-acyl groups
FOC61_RS03330	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FOC61_RS03355	COG4975	Glucose uptake
FOC61_RS03365	COG0551	DNA topoisomerase type I activity
FOC61_RS03365	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FOC61_RS03370	COG2252	PERMEase
FOC61_RS03385	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FOC61_RS03390	COG0088	Forms part of the polypeptide exit tunnel
FOC61_RS03395	COG0089	rRNA binding
FOC61_RS03400	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FOC61_RS03405	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FOC61_RS03415	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FOC61_RS03420	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FOC61_RS03430	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FOC61_RS03435	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FOC61_RS03440	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FOC61_RS03445	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FOC61_RS03450	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FOC61_RS03455	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FOC61_RS03460	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FOC61_RS03465	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FOC61_RS03470	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FOC61_RS03475	COG1841	ribosomal large subunit assembly
FOC61_RS03480	COG0200	Binds to the 23S rRNA
FOC61_RS03485	COG0201	protein transport
FOC61_RS03490	COG0563	adenylate kinase activity
FOC61_RS03495	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FOC61_RS03500	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FOC61_RS03505	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FOC61_RS03515	COG0202	RNA polymerase activity
FOC61_RS03520	COG0203	ribosomal protein L17
FOC61_RS03525	COG1122	ATPase activity
FOC61_RS03530	COG1122	ATPase activity
FOC61_RS03540	COG0101	tRNA pseudouridine synthase activity
FOC61_RS03545	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FOC61_RS03555	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FOC61_RS03560	COG1349	DNA-binding transcription factor activity
FOC61_RS03565	COG0698	ribose 5-phosphate isomerase
FOC61_RS03590	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FOC61_RS03590	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FOC61_RS03605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FOC61_RS03610	COG2130	NADP-dependent
FOC61_RS03615	COG0604	alcohol dehydrogenase
FOC61_RS03620	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FOC61_RS03635	COG1302	Protein conserved in bacteria
FOC61_RS03640	COG4264	IucA IucC family
FOC61_RS03645	COG2814	Major facilitator Superfamily
FOC61_RS03650	COG4264	IucA IucC family
FOC61_RS03655	COG3457	Alanine racemase
FOC61_RS03660	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FOC61_RS03665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FOC61_RS03670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FOC61_RS03680	COG2329	Antibiotic biosynthesis monooxygenase
FOC61_RS03690	COG1988	membrane-bound metal-dependent
FOC61_RS03695	COG4284	Utp--glucose-1-phosphate uridylyltransferase
FOC61_RS03700	COG1272	protein, Hemolysin III
FOC61_RS03715	COG2814	Major facilitator Superfamily
FOC61_RS03720	COG0489	protein tyrosine kinase activity
FOC61_RS03775	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
FOC61_RS03785	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FOC61_RS03800	COG3711	transcriptional antiterminator
FOC61_RS03810	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FOC61_RS03815	COG0561	phosphatase activity
FOC61_RS03835	COG0640	Transcriptional regulator
FOC61_RS03840	COG0702	epimerase
FOC61_RS03845	COG1482	cell wall glycoprotein biosynthetic process
FOC61_RS03865	COG0783	Belongs to the Dps family
FOC61_RS03875	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FOC61_RS03880	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
FOC61_RS03885	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FOC61_RS03895	COG1854	S-ribosylhomocysteine lyase activity
FOC61_RS03915	COG5146	pantothenate kinase activity
FOC61_RS03925	COG3343	RNA polymerase activity
FOC61_RS03930	COG0504	CTP synthase activity
FOC61_RS03940	COG0191	fructose-bisphosphate aldolase activity
FOC61_RS03945	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FOC61_RS03955	COG1012	belongs to the aldehyde dehydrogenase family
FOC61_RS03960	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FOC61_RS03965	COG0254	rRNA binding
FOC61_RS03970	COG1435	thymidine kinase activity
FOC61_RS03980	COG2890	protein-(glutamine-N5) methyltransferase activity
FOC61_RS03985	COG0009	L-threonylcarbamoyladenylate synthase
FOC61_RS03990	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FOC61_RS03995	COG4475	Protein of unknown function (DUF436)
FOC61_RS04000	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FOC61_RS04005	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FOC61_RS04010	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FOC61_RS04020	COG0356	it plays a direct role in the translocation of protons across the membrane
FOC61_RS04030	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FOC61_RS04035	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FOC61_RS04040	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FOC61_RS04045	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FOC61_RS04050	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FOC61_RS04055	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FOC61_RS04065	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FOC61_RS04070	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FOC61_RS04080	COG0629	single-stranded DNA binding
FOC61_RS04085	COG1388	LysM domain
FOC61_RS04090	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FOC61_RS04100	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
FOC61_RS04105	COG0352	thiamine-phosphate diphosphorylase activity
FOC61_RS04110	COG0706	membrane insertase activity
FOC61_RS04115	COG1418	mRNA catabolic process
FOC61_RS04120	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FOC61_RS04125	COG1937	Protein conserved in bacteria
FOC61_RS04140	COG0772	Belongs to the SEDS family
FOC61_RS04145	COG1181	Belongs to the D-alanine--D-alanine ligase family
FOC61_RS04150	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FOC61_RS04155	COG0513	Belongs to the DEAD box helicase family
FOC61_RS04170	COG3402	PFAM membrane-flanked domain
FOC61_RS04180	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FOC61_RS04190	COG2337	Toxic component of a toxin-antitoxin (TA) module
FOC61_RS04195	COG2208	phosphoserine phosphatase activity
FOC61_RS04210	COG1191	sigma factor activity
FOC61_RS04215	COG2183	response to ionizing radiation
FOC61_RS04220	COG3091	SprT-like family
FOC61_RS04255	COG0066	3-isopropylmalate dehydratase activity
FOC61_RS04260	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FOC61_RS04265	COG0473	3-isopropylmalate dehydrogenase activity
FOC61_RS04270	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FOC61_RS04275	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FOC61_RS04285	COG0028	Belongs to the TPP enzyme family
FOC61_RS04290	COG0129	dihydroxy-acid dehydratase activity
FOC61_RS04295	COG0802	atpase or kinase
FOC61_RS04300	COG1214	PFAM Peptidase M22, glycoprotease
FOC61_RS04305	COG0456	acetyltransferase
FOC61_RS04310	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FOC61_RS04320	COG0488	(ABC) transporter
FOC61_RS04325	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
FOC61_RS04335	COG2391	methyltransferase activity
FOC61_RS04340	COG0425	Belongs to the sulfur carrier protein TusA family
FOC61_RS04345	COG0004	ammonium transporteR
FOC61_RS04350	COG1609	Transcriptional regulator
FOC61_RS04355	COG1621	beta-fructofuranosidase activity
FOC61_RS04360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FOC61_RS04365	COG3279	Response regulator of the LytR AlgR family
FOC61_RS04410	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FOC61_RS04415	COG0459	protein refolding
FOC61_RS04440	COG1725	Transcriptional regulator
FOC61_RS04455	COG1131	(ABC) transporter
FOC61_RS04500	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FOC61_RS04505	COG2706	6-phosphogluconolactonase activity
FOC61_RS04510	COG1012	belongs to the aldehyde dehydrogenase family
FOC61_RS04515	COG1227	inorganic diphosphatase activity
FOC61_RS04520	COG1335	isochorismatase
FOC61_RS04530	COG0077	Prephenate dehydratase
FOC61_RS04540	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FOC61_RS04545	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FOC61_RS04550	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
FOC61_RS04560	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FOC61_RS04565	COG4496	protein, YerC YecD
FOC61_RS04570	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
FOC61_RS04575	COG0210	DNA helicase
FOC61_RS04580	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FOC61_RS04590	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FOC61_RS04595	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FOC61_RS04600	COG0154	amidase activity
FOC61_RS04605	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FOC61_RS04610	COG1597	lipid kinase activity
FOC61_RS04615	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FOC61_RS04635	COG1528	Iron-storage protein
FOC61_RS04655	COG4129	membrane
FOC61_RS04660	COG0024	Methionine aminopeptidase
FOC61_RS04680	COG2197	response regulator
FOC61_RS04685	COG1295	ribonuclease BN
FOC61_RS04695	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FOC61_RS04700	COG4840	Belongs to the UPF0435 family
FOC61_RS04705	COG2309	aminopeptidase activity
FOC61_RS04710	COG1607	acyl-coa hydrolase
FOC61_RS04715	COG0535	radical SAM domain protein
FOC61_RS04725	COG0693	protein deglycase activity
FOC61_RS04730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FOC61_RS04735	COG2137	regulation of response to DNA damage stimulus
FOC61_RS04745	COG1134	teichoic acid transport
FOC61_RS04745	COG1388	LysM domain
FOC61_RS04755	COG1988	membrane-bound metal-dependent
FOC61_RS04765	COG3557	Belongs to the UPF0374 family
FOC61_RS04775	COG4129	membrane
FOC61_RS04780	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FOC61_RS04785	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FOC61_RS04790	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FOC61_RS04795	COG0735	belongs to the Fur family
FOC61_RS04965	COG0765	amino acid transport
FOC61_RS04970	COG1126	abc transporter atp-binding protein
FOC61_RS04975	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FOC61_RS04985	COG0363	glucosamine-6-phosphate deaminase activity
FOC61_RS05000	COG0114	fumarate hydratase activity
FOC61_RS05005	COG0564	pseudouridine synthase activity
FOC61_RS05010	COG4585	Histidine kinase
FOC61_RS05010	COG2203	Gaf domain
FOC61_RS05015	COG2197	response regulator
FOC61_RS05025	COG4399	Belongs to the UPF0754 family
FOC61_RS05030	COG3679	Belongs to the UPF0342 family
FOC61_RS05035	COG0420	3'-5' exonuclease activity
FOC61_RS05045	COG3481	metal-dependent phosphohydrolase, HD sub domain
FOC61_RS05055	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FOC61_RS05070	COG0537	adenosine 5'-monophosphoramidase activity
FOC61_RS05075	COG1131	(ABC) transporter
FOC61_RS05080	COG4473	ABC transporter
FOC61_RS05085	COG2329	Antibiotic biosynthesis monooxygenase
FOC61_RS05090	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FOC61_RS05385	COG4195	phage-related replication protein
FOC61_RS05420	COG5632	N-Acetylmuramoyl-L-alanine amidase
FOC61_RS05420	COG1388	LysM domain
FOC61_RS05430	COG0318	PFAM AMP-dependent synthetase and ligase
FOC61_RS05445	COG0494	nUDIX hydrolase
FOC61_RS05450	COG1506	peptidase
FOC61_RS05460	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FOC61_RS05470	COG0656	L-ascorbic acid biosynthetic process
FOC61_RS05475	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FOC61_RS05480	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FOC61_RS05490	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FOC61_RS05505	COG1595	DNA-templated transcription, initiation
FOC61_RS05515	COG4193	domain, Protein
FOC61_RS05515	COG3266	domain, Protein
FOC61_RS05515	COG5632	N-Acetylmuramoyl-L-alanine amidase
FOC61_RS05525	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FOC61_RS05525	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FOC61_RS05535	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FOC61_RS05535	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FOC61_RS05540	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FOC61_RS05545	COG0506	proline dehydrogenase activity
FOC61_RS05550	COG2267	carboxylic ester hydrolase activity
FOC61_RS05560	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
FOC61_RS05565	COG1242	4 iron, 4 sulfur cluster binding
FOC61_RS05570	COG2814	Major facilitator Superfamily
FOC61_RS05575	COG0495	leucyl-tRNA aminoacylation
FOC61_RS05580	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FOC61_RS05590	COG2081	HI0933 family
FOC61_RS05595	COG2244	polysaccharide biosynthetic process
FOC61_RS05600	COG1187	pseudouridine synthase activity
FOC61_RS05610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FOC61_RS05615	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FOC61_RS05620	COG0510	thiamine kinase activity
FOC61_RS05625	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FOC61_RS05630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FOC61_RS05640	COG1363	Peptidase, m42
FOC61_RS05645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FOC61_RS05650	COG4848	Belongs to the UPF0354 family
FOC61_RS05655	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FOC61_RS05660	COG1674	ftsk spoiiie
FOC61_RS05665	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FOC61_RS05670	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
FOC61_RS05680	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
FOC61_RS05680	COG1605	Chorismate mutase
FOC61_RS05685	COG1609	Transcriptional regulator
FOC61_RS05695	COG0454	-acetyltransferase
FOC61_RS05700	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FOC61_RS05705	COG2759	Belongs to the formate--tetrahydrofolate ligase family
FOC61_RS05715	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FOC61_RS05730	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FOC61_RS05735	COG0204	Acyl-transferase
FOC61_RS05740	COG1263	PTS System
FOC61_RS05740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FOC61_RS05750	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FOC61_RS05760	COG1764	response to oxidative stress
FOC61_RS05765	COG0584	glycerophosphoryl diester phosphodiesterase
FOC61_RS05770	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FOC61_RS05775	COG1956	GAF domain-containing protein
FOC61_RS05780	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
FOC61_RS05785	COG1104	cysteine desulfurase activity
FOC61_RS05790	COG0301	tRNA thio-modification
FOC61_RS05795	COG0730	response to heat
FOC61_RS05800	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
FOC61_RS05805	COG0827	DNA restriction-modification system
FOC61_RS05810	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FOC61_RS05815	COG0589	response to stress
FOC61_RS05825	COG0006	proline dipeptidase activity
FOC61_RS05830	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FOC61_RS05840	COG4109	DRTGG domain
FOC61_RS05845	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FOC61_RS05850	COG0587	DNA-directed DNA polymerase activity
FOC61_RS05855	COG0281	malic enzyme
FOC61_RS05860	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FOC61_RS05865	COG0825	malonyl-CoA metabolic process
FOC61_RS05870	COG0205	6-phosphofructokinase activity
FOC61_RS05875	COG0469	pyruvate kinase activity
FOC61_RS05880	COG1113	amino acid transport
FOC61_RS05885	COG0372	Belongs to the citrate synthase family
FOC61_RS05890	COG0538	isocitrate dehydrogenase activity
FOC61_RS05895	COG0745	RESPONSE REGULATOR receiver
FOC61_RS05900	COG5002	protein histidine kinase activity
FOC61_RS05905	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FOC61_RS05905	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FOC61_RS05910	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FOC61_RS05915	COG0237	dephospho-CoA kinase activity
FOC61_RS05920	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FOC61_RS05925	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FOC61_RS05935	COG1484	DNA-dependent DNA replication
FOC61_RS05940	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FOC61_RS05945	COG0833	amino acid
FOC61_RS05950	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FOC61_RS05955	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FOC61_RS05960	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FOC61_RS05965	COG4112	unkown
FOC61_RS05975	COG0544	peptidyl-prolyl cis-trans isomerase activity
FOC61_RS05980	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FOC61_RS05985	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FOC61_RS05990	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FOC61_RS05995	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FOC61_RS06000	COG0181	hydroxymethylbilane synthase activity
FOC61_RS06010	COG0113	porphobilinogen synthase activity
FOC61_RS06015	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FOC61_RS06025	COG2818	Glycosylase
FOC61_RS06030	COG0525	valine-tRNA ligase activity
FOC61_RS06035	COG0285	dihydrofolate synthase activity
FOC61_RS06045	COG2003	Belongs to the UPF0758 family
FOC61_RS06080	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FOC61_RS06085	COG2868	ribosomal protein
FOC61_RS06090	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FOC61_RS06095	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FOC61_RS06100	COG4492	Belongs to the UPF0735 family
FOC61_RS06105	COG0632	four-way junction helicase activity
FOC61_RS06110	COG2255	four-way junction helicase activity
FOC61_RS06115	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FOC61_RS06125	COG1862	Preprotein translocase
FOC61_RS06130	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FOC61_RS06130	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FOC61_RS06135	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
FOC61_RS06135	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FOC61_RS06145	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FOC61_RS06150	COG1490	D-aminoacyl-tRNA deacylase activity
FOC61_RS06155	COG0860	N-Acetylmuramoyl-L-alanine amidase
FOC61_RS06165	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FOC61_RS06175	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FOC61_RS06180	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FOC61_RS06185	COG1959	2 iron, 2 sulfur cluster binding
FOC61_RS06195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FOC61_RS06200	COG1104	cysteine desulfurase activity
FOC61_RS06205	COG0482	sulfurtransferase activity
FOC61_RS06215	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FOC61_RS06220	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FOC61_RS06225	COG4472	Bacterial protein of unknown function (DUF965)
FOC61_RS06230	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FOC61_RS06235	COG3906	Belongs to the UPF0473 family
FOC61_RS06255	COG0572	uridine kinase
FOC61_RS06260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FOC61_RS06265	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FOC61_RS06270	COG1984	allophanate hydrolase subunit 2
FOC61_RS06275	COG0511	ligase activity, forming carbon-carbon bonds
FOC61_RS06280	COG0439	Biotin carboxylase
FOC61_RS06285	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FOC61_RS06290	COG1914	H( )-stimulated, divalent metal cation uptake system
FOC61_RS06295	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FOC61_RS06300	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
FOC61_RS06305	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FOC61_RS06315	COG1534	Rna-binding protein
FOC61_RS06320	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FOC61_RS06325	COG1713	HD superfamily hydrolase involved in NAD metabolism
FOC61_RS06330	COG0799	negative regulation of ribosome biogenesis
FOC61_RS06335	COG2226	methyltransferase
FOC61_RS06345	COG2131	deaminase
FOC61_RS06355	COG1466	dna polymerase III delta subunit
FOC61_RS06360	COG0268	Binds directly to 16S ribosomal RNA
FOC61_RS06365	COG0481	GTPase activity
FOC61_RS06370	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FOC61_RS06375	COG1420	regulation of RNA biosynthetic process
FOC61_RS06380	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FOC61_RS06385	COG0443	Heat shock 70 kDa protein
FOC61_RS06390	COG0484	heat shock protein binding
FOC61_RS06395	COG2264	protein methyltransferase activity
FOC61_RS06400	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FOC61_RS06405	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FOC61_RS06415	COG1030	water channel activity
FOC61_RS06420	COG4864	UPF0365 protein
FOC61_RS06430	COG1702	phosphate starvation-inducible protein PhoH
FOC61_RS06435	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FOC61_RS06445	COG0295	cytidine deaminase activity
FOC61_RS06450	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FOC61_RS06455	COG1381	Involved in DNA repair and RecF pathway recombination
FOC61_RS06460	COG0423	glycine-tRNA ligase activity
FOC61_RS06465	COG0517	IMP dehydrogenase activity
FOC61_RS06470	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FOC61_RS06475	COG0358	DNA primase activity
FOC61_RS06480	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FOC61_RS06485	COG2384	SAM-dependent methyltransferase
FOC61_RS06490	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FOC61_RS06495	COG0513	Belongs to the DEAD box helicase family
FOC61_RS06500	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
FOC61_RS06505	COG1121	(ABC) transporter
FOC61_RS06510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FOC61_RS06520	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FOC61_RS06530	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FOC61_RS06535	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FOC61_RS06545	COG4483	Protein conserved in bacteria
FOC61_RS06550	COG1940	carbohydrate kinase activity
FOC61_RS06555	COG0011	TIGRFAM Protein of
FOC61_RS06560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FOC61_RS06565	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FOC61_RS06575	COG4537	Required for transformation and DNA binding
FOC61_RS06595	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FOC61_RS06600	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FOC61_RS06615	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FOC61_RS06620	COG0095	Lipoate-protein ligase
FOC61_RS06635	COG0006	proline dipeptidase activity
FOC61_RS06640	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FOC61_RS06645	COG0511	ligase activity, forming carbon-carbon bonds
FOC61_RS06650	COG0439	Biotin carboxylase
FOC61_RS06655	COG1302	Protein conserved in bacteria
FOC61_RS06660	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FOC61_RS06665	COG1570	exodeoxyribonuclease VII activity
FOC61_RS06680	COG1438	arginine binding
FOC61_RS06685	COG0497	DNA recombination
FOC61_RS06690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FOC61_RS06695	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FOC61_RS06700	COG0022	dehydrogenase e1 component
FOC61_RS06705	COG0508	dehydrogenase complex catalyzes the overall conversion of
FOC61_RS06715	COG4129	membrane
FOC61_RS06725	COG2195	Cleaves the N-terminal amino acid of tripeptides
FOC61_RS06730	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FOC61_RS06735	COG0366	Alpha amylase catalytic
FOC61_RS06745	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FOC61_RS06750	COG1234	tRNA 3'-trailer cleavage
FOC61_RS06755	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FOC61_RS06760	COG1028	Short-chain dehydrogenase reductase Sdr
FOC61_RS06770	COG0667	Aldo Keto reductase
FOC61_RS06775	COG0494	nUDIX hydrolase
FOC61_RS06780	COG0735	belongs to the Fur family
FOC61_RS06785	COG4974	Belongs to the 'phage' integrase family
FOC61_RS06795	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FOC61_RS06800	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FOC61_RS06805	COG1187	pseudouridine synthase activity
FOC61_RS06810	COG0745	RESPONSE REGULATOR receiver
FOC61_RS06825	COG1141	Ferredoxin
FOC61_RS06835	COG0514	ATP-dependent DNA helicase (RecQ)
FOC61_RS06840	COG1388	LysM domain
FOC61_RS06845	COG0492	ferredoxin-NADP+ reductase activity
FOC61_RS06855	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FOC61_RS06860	COG0539	negative regulation of cytoplasmic translation
FOC61_RS06865	COG1160	GTP binding
FOC61_RS06870	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FOC61_RS06885	COG2226	methyltransferase
FOC61_RS06890	COG0142	geranyltranstransferase activity
FOC61_RS06895	COG0105	UTP biosynthetic process
FOC61_RS06900	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FOC61_RS06905	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FOC61_RS06910	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FOC61_RS06920	COG5582	Belongs to the UPF0302 family
FOC61_RS06925	COG4347	Protein of unknown function (DUF1405)
FOC61_RS06930	COG2738	Putative neutral zinc metallopeptidase
FOC61_RS06935	COG1694	Mazg nucleotide pyrophosphohydrolase
FOC61_RS06940	COG0438	transferase activity, transferring glycosyl groups
FOC61_RS06945	COG0617	tRNA 3'-terminal CCA addition
FOC61_RS06955	COG1199	ATP-dependent helicase activity
FOC61_RS06955	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FOC61_RS06960	COG0017	Asparaginyl-tRNA synthetase
FOC61_RS06965	COG3935	DnaD domain protein
FOC61_RS06970	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FOC61_RS06980	COG4499	WXG100 protein secretion system (Wss), protein YukC
FOC61_RS06980	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FOC61_RS06985	COG3331	DNA recombination
FOC61_RS06995	COG4474	Belongs to the UPF0398 family
FOC61_RS07000	COG3599	regulation of cell shape
FOC61_RS07010	COG0116	Belongs to the methyltransferase superfamily
FOC61_RS07020	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
FOC61_RS07025	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FOC61_RS07035	COG0328	RNA-DNA hybrid ribonuclease activity
FOC61_RS07040	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FOC61_RS07050	COG1413	lyase activity
FOC61_RS07055	COG1413	lyase activity
FOC61_RS07085	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FOC61_RS07090	COG2190	(PTS) system
FOC61_RS07095	COG4479	Belongs to the UPF0346 family
FOC61_RS07100	COG0793	Belongs to the peptidase S41A family
FOC61_RS07110	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FOC61_RS07115	COG0671	phosphoesterase, PA-phosphatase related
FOC61_RS07120	COG3842	ATPase activity
FOC61_RS07125	COG4209	transmembrane transport
FOC61_RS07135	COG0395	ABC-type sugar transport system, permease component
FOC61_RS07145	COG0534	Mate efflux family protein
FOC61_RS07150	COG1349	DNA-binding transcription factor activity
FOC61_RS07155	COG0745	RESPONSE REGULATOR receiver
FOC61_RS07160	COG5002	protein histidine kinase activity
FOC61_RS07165	COG0567	Dehydrogenase, E1 component
FOC61_RS07170	COG0508	dehydrogenase complex catalyzes the overall conversion of
FOC61_RS07175	COG3177	Filamentation induced by cAMP protein fic
FOC61_RS07200	COG0714	Associated with various cellular activities
FOC61_RS07205	COG4548	von Willebrand factor, type A
FOC61_RS07210	COG1114	Component of the transport system for branched-chain amino acids
FOC61_RS07215	COG3853	Toxic anion resistance protein (TelA)
FOC61_RS07225	COG1254	Belongs to the acylphosphatase family
FOC61_RS07235	COG1278	Cold shock
FOC61_RS07250	COG1473	amidohydrolase
FOC61_RS07260	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FOC61_RS07265	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FOC61_RS07270	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FOC61_RS07275	COG0527	aspartate kinase activity
FOC61_RS07280	COG0488	(ABC) transporter
FOC61_RS07285	COG2996	Protein conserved in bacteria
FOC61_RS07290	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FOC61_RS07295	COG0573	inorganic phosphate transmembrane transporter activity
FOC61_RS07300	COG0581	inorganic phosphate transmembrane transporter activity
FOC61_RS07305	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FOC61_RS07310	COG0704	Plays a role in the regulation of phosphate uptake
FOC61_RS07315	COG1164	Oligoendopeptidase f
FOC61_RS07350	COG2348	transferase activity, transferring amino-acyl groups
FOC61_RS07355	COG2348	transferase activity, transferring amino-acyl groups
FOC61_RS07365	COG0159	tryptophan synthase activity
FOC61_RS07370	COG0133	tryptophan synthase activity
FOC61_RS07375	COG0135	phosphoribosylanthranilate isomerase activity
FOC61_RS07380	COG0134	indole-3-glycerol-phosphate synthase activity
FOC61_RS07385	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FOC61_RS07400	COG1363	Peptidase, m42
FOC61_RS07405	COG0287	Prephenate dehydrogenase
FOC61_RS07410	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FOC61_RS07415	COG1942	4-Oxalocrotonate Tautomerase
FOC61_RS07430	COG0392	lysyltransferase activity
FOC61_RS07430	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FOC61_RS07435	COG0628	permease
FOC61_RS07440	COG3711	transcriptional antiterminator
FOC61_RS07445	COG1115	amino acid carrier protein
FOC61_RS07450	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FOC61_RS07455	COG0187	DNA topoisomerase II activity
FOC61_RS07460	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FOC61_RS07470	COG0824	Thioesterase
FOC61_RS07475	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FOC61_RS07480	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FOC61_RS07485	COG1970	mechanosensitive ion channel activity
FOC61_RS07490	COG0419	ATPase involved in DNA repair
FOC61_RS07495	COG0420	3'-5' exonuclease activity
FOC61_RS07500	COG4846	Membrane protein involved in cytochrome C biogenesis
FOC61_RS07510	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FOC61_RS07515	COG4224	UPF0291 protein
FOC61_RS07525	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FOC61_RS07530	COG2340	Cysteine-rich secretory protein family
FOC61_RS07535	COG0516	GMP reductase activity
FOC61_RS07540	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FOC61_RS07550	COG0753	catalase activity
FOC61_RS07555	COG0833	amino acid
FOC61_RS07580	COG0460	homoserine dehydrogenase
FOC61_RS07600	COG1525	nuclease
FOC61_RS07615	COG2197	response regulator
FOC61_RS07620	COG4585	Histidine kinase
FOC61_RS07630	COG1131	(ABC) transporter
FOC61_RS07635	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FOC61_RS07660	COG0174	glutamine synthetase
FOC61_RS07665	COG0789	Transcriptional regulator
FOC61_RS07670	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
FOC61_RS07675	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FOC61_RS07680	COG0386	Belongs to the glutathione peroxidase family
FOC61_RS07685	COG1923	regulation of RNA biosynthetic process
FOC61_RS07690	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FOC61_RS07700	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FOC61_RS07705	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FOC61_RS07710	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FOC61_RS07720	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FOC61_RS07725	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FOC61_RS07735	COG4550	Control of competence regulator ComK, YlbF/YmcA
FOC61_RS07740	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FOC61_RS07750	COG4195	phage-related replication protein
FOC61_RS07755	COG1013	pyruvate-flavodoxin oxidoreductase activity
FOC61_RS07760	COG0674	pyruvate-flavodoxin oxidoreductase activity
FOC61_RS07760	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FOC61_RS07765	COG1692	metallophosphoesterase
FOC61_RS07775	COG1418	mRNA catabolic process
FOC61_RS07780	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FOC61_RS07785	COG1058	Belongs to the CinA family
FOC61_RS07785	COG1546	Belongs to the CinA family
FOC61_RS07790	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FOC61_RS07805	COG0300	oxidoreductase activity
FOC61_RS07810	COG0612	Peptidase, M16
FOC61_RS07815	COG0612	Peptidase, M16
FOC61_RS07820	COG2188	Transcriptional regulator
FOC61_RS07825	COG1674	ftsk spoiiie
FOC61_RS07830	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FOC61_RS07835	COG1185	polyribonucleotide nucleotidyltransferase activity
FOC61_RS07840	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FOC61_RS07845	COG0196	riboflavin kinase activity
FOC61_RS07850	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FOC61_RS07855	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FOC61_RS07860	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FOC61_RS07865	COG1358	cellular component organization or biogenesis
FOC61_RS07870	COG2740	Nucleic-acid-binding protein implicated in transcription termination
FOC61_RS07875	COG0195	Participates in both transcription termination and antitermination
FOC61_RS07880	COG0779	Required for maturation of 30S ribosomal subunits
FOC61_RS07885	COG2176	DNA-directed DNA polymerase activity
FOC61_RS07890	COG0442	prolyl-tRNA aminoacylation
FOC61_RS07900	COG4589	Belongs to the CDS family
FOC61_RS07905	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FOC61_RS07910	COG0233	cytoplasmic translational termination
FOC61_RS07915	COG0528	UMP kinase activity
FOC61_RS07920	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FOC61_RS07925	COG0052	Belongs to the universal ribosomal protein uS2 family
FOC61_RS07940	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FOC61_RS07945	COG4974	Belongs to the 'phage' integrase family
FOC61_RS07950	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
FOC61_RS07955	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FOC61_RS07960	COG0758	DNA mediated transformation
FOC61_RS07965	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FOC61_RS07970	COG0045	succinate-CoA ligase (ADP-forming) activity
FOC61_RS07975	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FOC61_RS07985	COG4485	Bacterial membrane protein, YfhO
FOC61_RS08005	COG0335	large ribosomal subunit rRNA binding
FOC61_RS08010	COG0336	Belongs to the RNA methyltransferase TrmD family
FOC61_RS08015	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FOC61_RS08020	COG0228	four-way junction DNA binding
FOC61_RS08025	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FOC61_RS08030	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
FOC61_RS08035	COG0552	protein localization to endoplasmic reticulum
FOC61_RS08040	COG1196	nuclear chromosome segregation
FOC61_RS08045	COG0571	ribonuclease III activity
FOC61_RS08050	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FOC61_RS08065	COG0416	fatty acid biosynthetic process
FOC61_RS08070	COG1349	DNA-binding transcription factor activity
FOC61_RS08075	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FOC61_RS08090	COG1461	Dihydroxyacetone kinase
FOC61_RS08095	COG1302	Protein conserved in bacteria
FOC61_RS08100	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FOC61_RS08105	COG1564	THIamine pyrophosphokinase
FOC61_RS08110	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FOC61_RS08115	COG1162	GTPase activity
FOC61_RS08120	COG2807	transmembrane transport
FOC61_RS08130	COG0631	protein serine/threonine phosphatase activity
FOC61_RS08135	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FOC61_RS08140	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FOC61_RS08140	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FOC61_RS08145	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FOC61_RS08150	COG0242	peptide deformylase activity
FOC61_RS08160	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FOC61_RS08165	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FOC61_RS08170	COG1758	RNA polymerase activity
FOC61_RS08175	COG0194	GDP metabolic process
FOC61_RS08180	COG1293	RNA-binding protein homologous to eukaryotic snRNP
FOC61_RS08195	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FOC61_RS08200	COG0284	orotidine-5'-phosphate decarboxylase activity
FOC61_RS08205	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FOC61_RS08210	COG0505	Belongs to the CarA family
FOC61_RS08215	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FOC61_RS08220	COG0540	Belongs to the ATCase OTCase family
FOC61_RS08225	COG2233	PERMEase
FOC61_RS08230	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FOC61_RS08235	COG0564	pseudouridine synthase activity
FOC61_RS08240	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FOC61_RS08250	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FOC61_RS08255	COG3599	regulation of cell shape
FOC61_RS08265	COG0762	integral membrane protein
FOC61_RS08270	COG1799	cell septum assembly
FOC61_RS08275	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FOC61_RS08285	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FOC61_RS08290	COG0849	cell division
FOC61_RS08295	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FOC61_RS08300	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FOC61_RS08305	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FOC61_RS08315	COG4839	cell division protein FtsL
FOC61_RS08320	COG0275	rRNA processing
FOC61_RS08330	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
FOC61_RS08335	COG0454	-acetyltransferase
FOC61_RS08340	COG1011	Hydrolase
FOC61_RS08370	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FOC61_RS08375	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FOC61_RS08380	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FOC61_RS08385	COG1053	succinate dehydrogenase
FOC61_RS08390	COG2009	succinate dehydrogenase
FOC61_RS08395	COG0322	excinuclease ABC activity
FOC61_RS08400	COG3118	belongs to the thioredoxin family
FOC61_RS08405	COG1193	negative regulation of DNA recombination
FOC61_RS08410	COG1796	DNA polymerase
FOC61_RS08410	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FOC61_RS08415	COG1286	toxin biosynthetic process
FOC61_RS08420	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
FOC61_RS08425	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FOC61_RS08430	COG0072	phenylalanine-tRNA ligase activity
FOC61_RS08430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FOC61_RS08435	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FOC61_RS08440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FOC61_RS08450	COG4509	Sortase family
FOC61_RS08495	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FOC61_RS08510	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FOC61_RS08515	COG0742	ribosomal rna small subunit methyltransferase
FOC61_RS08525	COG4471	UPF0298 protein
FOC61_RS08530	COG0584	glycerophosphoryl diester phosphodiesterase
FOC61_RS08535	COG3679	Belongs to the UPF0342 family
FOC61_RS08550	COG0109	protoheme IX farnesyltransferase activity
FOC61_RS08555	COG1612	heme a metabolic process
FOC61_RS08565	COG0772	Belongs to the SEDS family
FOC61_RS08570	COG4838	Belongs to the UPF0358 family
FOC61_RS08575	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FOC61_RS08580	COG4896	Protein conserved in bacteria
FOC61_RS08595	COG0483	inositol monophosphate 1-phosphatase activity
FOC61_RS08600	COG4493	Belongs to the UPF0637 family
FOC61_RS08605	COG1914	H( )-stimulated, divalent metal cation uptake system
FOC61_RS08630	COG1176	ABC-type spermidine putrescine transport system, permease component I
FOC61_RS08645	COG4476	Belongs to the UPF0223 family
FOC61_RS08655	COG0508	dehydrogenase complex catalyzes the overall conversion of
FOC61_RS08660	COG0022	dehydrogenase e1 component
FOC61_RS08665	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FOC61_RS08675	COG0242	peptide deformylase activity
FOC61_RS08685	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FOC61_RS08695	COG0569	domain protein
FOC61_RS08700	COG1294	oxidase, subunit
FOC61_RS08705	COG1271	oxidase subunit
FOC61_RS08720	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FOC61_RS08730	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FOC61_RS08745	COG4172	Belongs to the ABC transporter superfamily
FOC61_RS08750	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
FOC61_RS08755	COG0151	Belongs to the GarS family
FOC61_RS08760	COG0138	bifunctional purine biosynthesis protein purh
FOC61_RS08765	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FOC61_RS08770	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FOC61_RS08775	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FOC61_RS08780	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FOC61_RS08785	COG0047	phosphoribosylformylglycinamidine synthase activity
FOC61_RS08790	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FOC61_RS08795	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FOC61_RS08800	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FOC61_RS08805	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FOC61_RS08810	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FOC61_RS08815	COG1017	nitric oxide dioxygenase activity
FOC61_RS08815	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FOC61_RS08825	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FOC61_RS08830	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FOC61_RS08840	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FOC61_RS08855	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FOC61_RS08860	COG1316	TRANSCRIPTIONal
FOC61_RS08885	COG3594	Acyltransferase
FOC61_RS08890	COG0436	Aminotransferase
FOC61_RS08895	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FOC61_RS08905	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FOC61_RS08910	COG1169	isochorismate synthase
FOC61_RS08915	COG1575	Belongs to the MenA family. Type 1 subfamily
FOC61_RS08985	COG4873	Protein conserved in bacteria
FOC61_RS08995	COG0737	Belongs to the 5'-nucleotidase family
FOC61_RS09000	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FOC61_RS09005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FOC61_RS09010	COG0861	Integral membrane protein TerC family
FOC61_RS09015	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FOC61_RS09025	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FOC61_RS09030	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FOC61_RS09035	COG2814	Major facilitator Superfamily
FOC61_RS09040	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
FOC61_RS09045	COG2382	esterase
FOC61_RS09050	COG0628	permease
FOC61_RS09060	COG0569	domain protein
FOC61_RS09060	COG0475	glutathione-regulated potassium exporter activity
FOC61_RS09065	COG2239	Acts as a magnesium transporter
FOC61_RS09070	COG0564	pseudouridine synthase activity
FOC61_RS09075	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FOC61_RS09080	COG2357	RelA SpoT domain protein
FOC61_RS09090	COG4116	CYTH
FOC61_RS09095	COG2346	COG2346, Truncated hemoglobins
FOC61_RS09105	COG1164	Oligoendopeptidase f
FOC61_RS09115	COG4862	establishment of competence for transformation
FOC61_RS09120	COG1393	Belongs to the ArsC family
FOC61_RS09125	COG0180	Tryptophanyl-tRNA synthetase
FOC61_RS09130	COG4166	transmembrane transport
FOC61_RS09135	COG4608	Belongs to the ABC transporter superfamily
FOC61_RS09140	COG0444	Belongs to the ABC transporter superfamily
FOC61_RS09145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FOC61_RS09150	COG0601	transmembrane transport
FOC61_RS09165	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FOC61_RS09175	COG1881	PFAM PEBP family protein
FOC61_RS09180	COG0542	response to heat
FOC61_RS09195	COG0561	phosphatase activity
FOC61_RS09200	COG0446	pyridine nucleotide-disulphide oxidoreductase
FOC61_RS09210	COG0179	Fumarylacetoacetate (FAA) hydrolase
FOC61_RS09215	COG1074	ATP-dependent DNA helicase activity
FOC61_RS09220	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
FOC61_RS09235	COG0398	Pfam SNARE associated Golgi protein
FOC61_RS09240	COG0166	Belongs to the GPI family
FOC61_RS09245	COG0137	argininosuccinate synthase activity
FOC61_RS09250	COG0165	Argininosuccinate lyase
FOC61_RS09255	COG0584	glycerophosphoryl diester phosphodiesterase
FOC61_RS09270	COG1902	pentaerythritol trinitrate reductase activity
FOC61_RS09275	COG1098	S1 RNA binding domain
FOC61_RS09280	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FOC61_RS09290	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FOC61_RS09290	COG2111	Na H antiporter
FOC61_RS09295	COG2111	Na H antiporter
FOC61_RS09300	COG1006	Multisubunit Na H antiporter MnhC subunit
FOC61_RS09305	COG0651	ATP synthesis coupled electron transport
FOC61_RS09310	COG1863	multisubunit Na H antiporter MnhE subunit
FOC61_RS09315	COG2212	antiporter activity
FOC61_RS09320	COG1320	monovalent cation:proton antiporter activity
FOC61_RS09330	COG2050	protein possibly involved in aromatic compounds catabolism
FOC61_RS09335	COG2056	Na+-H+ antiporter family
FOC61_RS09340	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FOC61_RS09345	COG1252	NADH dehydrogenase
FOC61_RS09350	COG0316	Belongs to the HesB IscA family
FOC61_RS09355	COG4844	belongs to the
FOC61_RS09360	COG1252	NADH dehydrogenase
FOC61_RS09365	COG4837	Protein of unknown function (DUF1462)
FOC61_RS09370	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FOC61_RS09375	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
FOC61_RS09385	COG1696	Membrane protein involved in D-alanine export
FOC61_RS09390	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FOC61_RS09405	COG0647	UMP catabolic process
FOC61_RS09410	COG2445	Protein of unknown function DUF86
FOC61_RS09420	COG4470	Protein conserved in bacteria
FOC61_RS09425	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FOC61_RS09430	COG0737	Belongs to the 5'-nucleotidase family
FOC61_RS09435	COG0730	response to heat
FOC61_RS09440	COG1801	Protein of unknown function DUF72
FOC61_RS09445	COG2070	2-Nitropropane dioxygenase
FOC61_RS09450	COG1253	flavin adenine dinucleotide binding
FOC61_RS09455	COG0719	Fe-S assembly protein
FOC61_RS09460	COG0822	iron-sulfur transferase activity
FOC61_RS09465	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FOC61_RS09470	COG0719	Fe-S assembly protein
FOC61_RS09475	COG0396	ATPase activity
FOC61_RS09495	COG1464	Belongs to the NlpA lipoprotein family
FOC61_RS09500	COG2011	ABC-type metal ion transport system permease component
FOC61_RS09505	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FOC61_RS09515	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
FOC61_RS09520	COG0509	glycine decarboxylation via glycine cleavage system
FOC61_RS09525	COG1393	Belongs to the ArsC family
FOC61_RS09530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FOC61_RS09540	COG0710	3-dehydroquinate dehydratase activity
FOC61_RS09545	COG1764	response to oxidative stress
FOC61_RS09555	COG1279	arginine transmembrane transporter activity
FOC61_RS09560	COG0406	alpha-ribazole phosphatase activity
FOC61_RS09600	COG4195	phage-related replication protein
FOC61_RS09620	COG1278	Cold shock
FOC61_RS09670	COG0456	acetyltransferase
FOC61_RS09680	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FOC61_RS09685	COG0557	exoribonuclease II activity
FOC61_RS09690	COG1647	Serine aminopeptidase, S33
FOC61_RS09695	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FOC61_RS09705	COG0148	phosphopyruvate hydratase activity
FOC61_RS09710	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FOC61_RS09715	COG0149	triose-phosphate isomerase activity
FOC61_RS09720	COG0126	phosphoglycerate kinase activity
FOC61_RS09725	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FOC61_RS09730	COG2390	Transcriptional regulator
FOC61_RS09750	COG1090	epimerase
FOC61_RS09760	COG0740	serine-type endopeptidase activity
FOC61_RS09770	COG1481	regulation of sporulation
FOC61_RS09775	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FOC61_RS09780	COG1660	Displays ATPase and GTPase activities
FOC61_RS09785	COG0492	ferredoxin-NADP+ reductase activity
FOC61_RS09795	COG0110	maltose O-acetyltransferase activity
FOC61_RS09800	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FOC61_RS09805	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
FOC61_RS09810	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FOC61_RS09815	COG0556	nucleotide-excision repair
FOC61_RS09830	COG1388	LysM domain
FOC61_RS09830	COG3942	CHAP domain
FOC61_RS09840	COG0653	protein targeting
FOC61_RS09850	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FOC61_RS09855	COG1040	competence protein
FOC61_RS09870	COG1739	Uncharacterized protein family UPF0029
FOC61_RS09875	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FOC61_RS09895	COG2195	Cleaves the N-terminal amino acid of tripeptides
FOC61_RS09900	COG1929	Belongs to the glycerate kinase type-1 family
FOC61_RS09920	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FOC61_RS09930	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FOC61_RS09935	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FOC61_RS09940	COG1780	Probably involved in ribonucleotide reductase function
FOC61_RS09955	COG3104	oligopeptide transport
FOC61_RS09960	COG1597	lipid kinase activity
FOC61_RS09970	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FOC61_RS09975	COG1174	glycine betaine transport
FOC61_RS09985	COG0514	ATP-dependent DNA helicase (RecQ)
FOC61_RS09990	COG0488	(ABC) transporter
FOC61_RS10000	COG1368	sulfuric ester hydrolase activity
FOC61_RS10010	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FOC61_RS10025	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FOC61_RS10035	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FOC61_RS10040	COG0720	synthase
FOC61_RS10045	COG0602	queuosine metabolic process
FOC61_RS10065	COG0745	RESPONSE REGULATOR receiver
FOC61_RS10070	COG5002	protein histidine kinase activity
FOC61_RS10075	COG0463	Glycosyl transferase, family 2
FOC61_RS10080	COG0656	L-ascorbic acid biosynthetic process
FOC61_RS10085	COG1253	flavin adenine dinucleotide binding
FOC61_RS10090	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FOC61_RS10095	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FOC61_RS10095	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FOC61_RS10095	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FOC61_RS10100	COG1105	Belongs to the carbohydrate kinase PfkB family
FOC61_RS10105	COG1349	DNA-binding transcription factor activity
FOC61_RS10110	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FOC61_RS10140	COG0471	metal ion transport
FOC61_RS10145	COG0039	L-malate dehydrogenase activity
FOC61_RS10155	COG0523	cobalamin synthesis protein
FOC61_RS10165	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FOC61_RS10170	COG4988	ABC transporter
FOC61_RS10175	COG1968	undecaprenyl-diphosphatase activity
FOC61_RS10185	COG1671	Belongs to the UPF0178 family
FOC61_RS10190	COG1611	Belongs to the LOG family
FOC61_RS10195	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FOC61_RS10220	COG2839	Protein conserved in bacteria
FOC61_RS10230	COG0583	DNA-binding transcription factor activity
FOC61_RS10245	COG0217	transcriptional regulatory protein
FOC61_RS10265	COG1388	LysM domain
FOC61_RS10265	COG3942	CHAP domain
FOC61_RS10270	COG0306	phosphate transporter
FOC61_RS10275	COG1392	Phosphate transport regulator
FOC61_RS10280	COG0577	efflux transmembrane transporter activity
FOC61_RS10285	COG1136	(ABC) transporter
FOC61_RS10290	COG2205	protein histidine kinase activity
FOC61_RS10295	COG0745	RESPONSE REGULATOR receiver
FOC61_RS10300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FOC61_RS10315	COG3949	Membrane
FOC61_RS10325	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
FOC61_RS10335	COG2376	Dihydroxyacetone kinase
FOC61_RS10340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FOC61_RS10345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FOC61_RS10350	COG1120	ATPase activity
FOC61_RS10355	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FOC61_RS10365	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FOC61_RS10370	COG1132	(ABC) transporter
FOC61_RS10375	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FOC61_RS10385	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FOC61_RS10390	COG1682	transport, permease protein
FOC61_RS10395	COG1134	teichoic acid transport
FOC61_RS10410	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
FOC61_RS10420	COG1321	iron dependent repressor
FOC61_RS10425	COG1121	(ABC) transporter
FOC61_RS10430	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FOC61_RS10435	COG0803	Belongs to the bacterial solute-binding protein 9 family
FOC61_RS10445	COG1320	monovalent cation:proton antiporter activity
FOC61_RS10450	COG2212	antiporter activity
FOC61_RS10455	COG1863	multisubunit Na H antiporter MnhE subunit
FOC61_RS10460	COG0651	ATP synthesis coupled electron transport
FOC61_RS10465	COG1006	Multisubunit Na H antiporter MnhC subunit
FOC61_RS10470	COG2111	Na H antiporter
FOC61_RS10475	COG2111	Na H antiporter
FOC61_RS10475	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FOC61_RS10495	COG2311	Membrane
FOC61_RS10510	COG1131	(ABC) transporter
FOC61_RS10560	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FOC61_RS10590	COG2235	arginine
FOC61_RS10600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FOC61_RS10605	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FOC61_RS10645	COG3237	CsbD-like
FOC61_RS10675	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FOC61_RS10680	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FOC61_RS10690	COG0446	pyridine nucleotide-disulphide oxidoreductase
FOC61_RS10715	COG0640	Transcriptional regulator
FOC61_RS10750	COG2161	toxin-antitoxin pair type II binding
FOC61_RS10825	COG0596	Alpha beta hydrolase
FOC61_RS10850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FOC61_RS10855	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FOC61_RS10870	COG0789	Transcriptional regulator
FOC61_RS10875	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FOC61_RS10880	COG0018	arginyl-trna synthetase
FOC61_RS10895	COG3875	lactate racemase activity
FOC61_RS10900	COG1606	tRNA processing
FOC61_RS10905	COG1691	(AIR) carboxylase
FOC61_RS10910	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
FOC61_RS10925	COG1078	dGTPase activity
FOC61_RS10935	COG0655	NAD(P)H dehydrogenase (quinone) activity
FOC61_RS10940	COG0667	Aldo Keto reductase
FOC61_RS10955	COG4844	belongs to the
FOC61_RS10975	COG0095	Lipoate-protein ligase
FOC61_RS10980	COG0280	phosphate acetyltransferase
FOC61_RS11005	COG2363	Small membrane protein
FOC61_RS11015	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FOC61_RS11020	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
FOC61_RS11025	COG0351	phosphomethylpyrimidine kinase
FOC61_RS11055	COG0183	Belongs to the thiolase family
FOC61_RS11060	COG0318	PFAM AMP-dependent synthetase and ligase
FOC61_RS11075	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
FOC61_RS11080	COG0363	glucosamine-6-phosphate deaminase activity
FOC61_RS11085	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FOC61_RS11100	COG2271	Major facilitator Superfamily
FOC61_RS11105	COG0438	transferase activity, transferring glycosyl groups
FOC61_RS11110	COG0431	NADPH-dependent FMN reductase
FOC61_RS11115	COG0561	phosphatase activity
FOC61_RS11125	COG1428	Deoxynucleoside kinase
FOC61_RS11130	COG1428	Deoxynucleoside kinase
FOC61_RS11140	COG0546	phosphoglycolate phosphatase activity
FOC61_RS11145	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FOC61_RS11155	COG0737	Belongs to the 5'-nucleotidase family
FOC61_RS11180	COG1473	amidohydrolase
FOC61_RS11185	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FOC61_RS11190	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FOC61_RS11200	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FOC61_RS11210	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FOC61_RS11215	COG0085	RNA polymerase activity
FOC61_RS11225	COG0222	ribosome binding
FOC61_RS11230	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FOC61_RS11235	COG0081	regulation of translation
FOC61_RS11240	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FOC61_RS11245	COG0250	Participates in transcription elongation, termination and antitermination
FOC61_RS11250	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FOC61_RS11255	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FOC61_RS11265	COG3688	RNA-binding protein containing a PIN domain
FOC61_RS11275	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
FOC61_RS11280	COG0215	cysteine-tRNA ligase activity
FOC61_RS11285	COG1045	serine acetyltransferase
FOC61_RS11290	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FOC61_RS11295	COG4956	integral membrane protein (PIN domain superfamily)
FOC61_RS11300	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FOC61_RS11305	COG0542	response to heat
FOC61_RS11310	COG3869	Catalyzes the specific phosphorylation of arginine residues in
FOC61_RS11315	COG3880	PFAM UvrB UvrC protein
FOC61_RS11320	COG4463	regulation of RNA biosynthetic process
FOC61_RS11325	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FOC61_RS11330	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
FOC61_RS11335	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
FOC61_RS11340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FOC61_RS11425	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FOC61_RS11430	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FOC61_RS11435	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FOC61_RS11445	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FOC61_RS11450	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FOC61_RS11455	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FOC61_RS11465	COG0037	tRNA processing
FOC61_RS11470	COG1098	S1 RNA binding domain
FOC61_RS11480	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FOC61_RS11485	COG3956	TIGRFAM MazG family protein
FOC61_RS11490	COG2244	polysaccharide biosynthetic process
FOC61_RS11495	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FOC61_RS11505	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FOC61_RS11510	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FOC61_RS11515	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FOC61_RS11520	COG2088	sporulation resulting in formation of a cellular spore
FOC61_RS11525	COG0251	oxidation-reduction process
FOC61_RS11530	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FOC61_RS11535	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FOC61_RS11540	COG4466	Protein conserved in bacteria
FOC61_RS11545	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FOC61_RS11550	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
FOC61_RS11555	COG0084	hydrolase, TatD family'
FOC61_RS11560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FOC61_RS11560	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FOC61_RS11565	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FOC61_RS11570	COG2827	Endonuclease containing a URI domain
FOC61_RS11575	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FOC61_RS11580	COG4467	Involved in initiation control of chromosome replication
FOC61_RS11585	COG1774	PSP1 C-terminal conserved region
FOC61_RS11590	COG0470	DNA polymerase III
FOC61_RS11595	COG3870	Protein conserved in bacteria
FOC61_RS11600	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FOC61_RS11605	COG1982	Orn Lys Arg decarboxylase major
FOC61_RS11630	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FOC61_RS11635	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FOC61_RS11640	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FOC61_RS11660	COG0493	'glutamate synthase
FOC61_RS11670	COG0583	DNA-binding transcription factor activity
FOC61_RS11725	COG1388	LysM domain
FOC61_RS11725	COG3942	CHAP domain
FOC61_RS11735	COG0626	cystathionine gamma-synthase activity
FOC61_RS11740	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FOC61_RS11755	COG0733	neurotransmitter:sodium symporter activity
FOC61_RS11765	COG1647	Serine aminopeptidase, S33
FOC61_RS11790	COG5609	conserved protein (DUF2294)
FOC61_RS11795	COG3002	Belongs to the UPF0753 family
FOC61_RS11800	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FOC61_RS11825	COG0523	cobalamin synthesis protein
FOC61_RS11835	COG2211	Major facilitator Superfamily
FOC61_RS11955	COG0582	viral genome integration into host DNA
FOC61_RS11960	COG0519	Catalyzes the synthesis of GMP from XMP
FOC61_RS11960	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FOC61_RS11965	COG0516	GMP reductase activity
FOC61_RS11965	COG0517	IMP dehydrogenase activity
FOC61_RS11970	COG2233	PERMEase
FOC61_RS11975	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FOC61_RS11990	COG5183	chlorophyll binding
FOC61_RS11995	COG1823	symporter activity
FOC61_RS12000	COG0778	Nitroreductase
FOC61_RS12010	COG0450	alkyl hydroperoxide reductase
FOC61_RS12015	COG3634	alkyl hydroperoxide reductase activity
FOC61_RS12035	COG1280	lysine exporter protein (LysE YggA)
FOC61_RS12080	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FOC61_RS12090	COG0360	Binds together with S18 to 16S ribosomal RNA
FOC61_RS12100	COG1011	Hydrolase
FOC61_RS12125	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FOC61_RS12145	COG0012	GTP binding
FOC61_RS12150	COG4481	Protein conserved in bacteria
FOC61_RS12155	COG0668	transmembrane transport
FOC61_RS12160	COG1475	DNA binding
FOC61_RS12165	COG0626	cystathionine gamma-synthase activity
FOC61_RS12170	COG0626	cystathionine gamma-synthase activity
FOC61_RS12175	COG0646	methionine synthase
FOC61_RS12175	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FOC61_RS12200	COG1131	(ABC) transporter
FOC61_RS12240	COG2217	Heavy metal translocating P-type atpase
FOC61_RS12245	COG1937	Protein conserved in bacteria
FOC61_RS12285	COG1131	(ABC) transporter
FOC61_RS12305	COG0488	(ABC) transporter