locus-tag	class	description
DWB96_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DWB96_RS00010	COG0592	DNA-directed DNA polymerase activity
DWB96_RS00015	COG2501	S4 domain
DWB96_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DWB96_RS00025	COG0187	DNA topoisomerase II activity
DWB96_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DWB96_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DWB96_RS00050	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DWB96_RS00060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DWB96_RS00070	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
DWB96_RS00075	COG0359	binds to the 23S rRNA
DWB96_RS00080	COG0305	Participates in initiation and elongation during chromosome replication
DWB96_RS00085	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DWB96_RS00100	COG0745	RESPONSE REGULATOR receiver
DWB96_RS00105	COG5002	protein histidine kinase activity
DWB96_RS00110	COG4863	YycH protein
DWB96_RS00120	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DWB96_RS00125	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DWB96_RS00160	COG3586	endonuclease activity
DWB96_RS00185	COG1757	Na H antiporter
DWB96_RS00195	COG1755	Isoprenylcysteine carboxyl methyltransferase
DWB96_RS00200	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DWB96_RS00235	COG1136	(ABC) transporter
DWB96_RS00240	COG1959	2 iron, 2 sulfur cluster binding
DWB96_RS00245	COG2910	NAD(P)H-binding
DWB96_RS00295	COG1129	ABC transporter
DWB96_RS00310	COG1132	(ABC) transporter
DWB96_RS00310	COG2375	cellular response to nickel ion
DWB96_RS00315	COG1132	(ABC) transporter
DWB96_RS00340	COG1021	2,3-dihydroxybenzoate-AMP ligase
DWB96_RS00345	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DWB96_RS00345	COG2226	methyltransferase
DWB96_RS00345	COG3433	isochorismatase activity
DWB96_RS00360	COG0745	RESPONSE REGULATOR receiver
DWB96_RS00365	COG2205	protein histidine kinase activity
DWB96_RS00375	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DWB96_RS00380	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DWB96_RS00395	COG0747	negative chemotaxis
DWB96_RS00400	COG0601	transmembrane transport
DWB96_RS00410	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DWB96_RS00415	COG1124	(ABC) transporter
DWB96_RS00460	COG0601	transmembrane transport
DWB96_RS00470	COG0444	Belongs to the ABC transporter superfamily
DWB96_RS00475	COG1124	(ABC) transporter
DWB96_RS00500	COG1114	Component of the transport system for branched-chain amino acids
DWB96_RS00510	COG1288	antiporter activity
DWB96_RS00520	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DWB96_RS00530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DWB96_RS00555	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
DWB96_RS00560	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DWB96_RS00595	COG2814	Major facilitator Superfamily
DWB96_RS00600	COG0583	DNA-binding transcription factor activity
DWB96_RS00620	COG1131	(ABC) transporter
DWB96_RS00630	COG2205	protein histidine kinase activity
DWB96_RS00665	COG2814	Major facilitator Superfamily
DWB96_RS00690	COG1012	belongs to the aldehyde dehydrogenase family
DWB96_RS00695	COG2318	DinB family
DWB96_RS00700	COG4221	oxidoreductase activity
DWB96_RS00705	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
DWB96_RS00710	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
DWB96_RS00715	COG2962	Rard protein
DWB96_RS00720	COG2409	Drug exporters of the RND superfamily
DWB96_RS00720	COG1033	growth of symbiont in host cell
DWB96_RS00735	COG0471	metal ion transport
DWB96_RS00755	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
DWB96_RS00770	COG1054	Belongs to the UPF0176 family
DWB96_RS00775	COG3386	PFAM SMP-30 Gluconolaconase
DWB96_RS00785	COG2353	YceI-like domain
DWB96_RS00795	COG0579	oxidoreductase
DWB96_RS00805	COG1686	Belongs to the peptidase S11 family
DWB96_RS00830	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
DWB96_RS00835	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DWB96_RS00840	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DWB96_RS00845	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DWB96_RS00850	COG0131	Imidazoleglycerol-phosphate dehydratase
DWB96_RS00855	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DWB96_RS00860	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DWB96_RS00865	COG0107	imidazoleglycerol-phosphate synthase activity
DWB96_RS00870	COG0140	phosphoribosyl-ATP diphosphatase activity
DWB96_RS00870	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DWB96_RS00895	COG0726	polysaccharide deacetylase
DWB96_RS00905	COG1215	transferase activity, transferring glycosyl groups
DWB96_RS00925	COG2814	Major facilitator Superfamily
DWB96_RS00935	COG0737	Belongs to the 5'-nucleotidase family
DWB96_RS00950	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
DWB96_RS00955	COG3639	organic phosphonate transmembrane transporter activity
DWB96_RS00965	COG0702	epimerase
DWB96_RS01040	COG2409	Drug exporters of the RND superfamily
DWB96_RS01050	COG0583	DNA-binding transcription factor activity
DWB96_RS01055	COG3842	ATPase activity
DWB96_RS01060	COG1840	ABC-type Fe3 transport system, periplasmic component
DWB96_RS01070	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DWB96_RS01080	COG1764	response to oxidative stress
DWB96_RS01115	COG3942	CHAP domain
DWB96_RS01115	COG1705	Flagellar rod assembly protein muramidase FlgJ
DWB96_RS01125	COG1482	cell wall glycoprotein biosynthetic process
DWB96_RS01130	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DWB96_RS01130	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DWB96_RS01130	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DWB96_RS01135	COG3711	transcriptional antiterminator
DWB96_RS01135	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DWB96_RS01145	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DWB96_RS01280	COG2235	arginine
DWB96_RS01300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DWB96_RS01320	COG2843	Capsule synthesis protein
DWB96_RS01340	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DWB96_RS01345	COG3961	Belongs to the TPP enzyme family
DWB96_RS01350	COG1846	Transcriptional regulator
DWB96_RS01355	COG4195	phage-related replication protein
DWB96_RS01360	COG4195	phage-related replication protein
DWB96_RS01365	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DWB96_RS01440	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DWB96_RS01445	COG0110	maltose O-acetyltransferase activity
DWB96_RS01450	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DWB96_RS01455	COG1316	TRANSCRIPTIONal
DWB96_RS01460	COG1785	Belongs to the alkaline phosphatase family
DWB96_RS01470	COG2205	protein histidine kinase activity
DWB96_RS01475	COG1136	(ABC) transporter
DWB96_RS01490	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DWB96_RS01515	COG1846	Transcriptional regulator
DWB96_RS01525	COG0386	Belongs to the glutathione peroxidase family
DWB96_RS01530	COG0175	sulfate reduction
DWB96_RS01535	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DWB96_RS01540	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DWB96_RS01555	COG0730	response to heat
DWB96_RS01560	COG2046	Belongs to the sulfate adenylyltransferase family
DWB96_RS01565	COG0529	Catalyzes the synthesis of activated sulfate
DWB96_RS01575	COG3942	CHAP domain
DWB96_RS01585	COG1328	CTP reductase activity
DWB96_RS01590	COG0602	queuosine metabolic process
DWB96_RS01595	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
DWB96_RS01605	COG1510	regulation of RNA biosynthetic process
DWB96_RS01610	COG1012	belongs to the aldehyde dehydrogenase family
DWB96_RS01615	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
DWB96_RS01620	COG1473	amidohydrolase
DWB96_RS01640	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DWB96_RS01645	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DWB96_RS01645	COG0574	Belongs to the PEP-utilizing enzyme family
DWB96_RS01650	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DWB96_RS01655	COG0579	oxidoreductase
DWB96_RS01685	COG3588	fructose-bisphosphate aldolase
DWB96_RS01700	COG0446	pyridine nucleotide-disulphide oxidoreductase
DWB96_RS01735	COG0531	amino acid
DWB96_RS01745	COG0583	DNA-binding transcription factor activity
DWB96_RS01750	COG0039	L-malate dehydrogenase activity
DWB96_RS01755	COG0028	Belongs to the TPP enzyme family
DWB96_RS01760	COG3527	Alpha-acetolactate decarboxylase
DWB96_RS01770	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DWB96_RS01775	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DWB96_RS01790	COG4640	response to antibiotic
DWB96_RS01800	COG4640	response to antibiotic
DWB96_RS01825	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DWB96_RS01835	COG0167	dihydroorotate dehydrogenase activity
DWB96_RS01840	COG3001	Fructosamine kinase
DWB96_RS01855	COG0596	Alpha beta hydrolase
DWB96_RS01900	COG1113	amino acid transport
DWB96_RS01915	COG0741	lytic transglycosylase activity
DWB96_RS01945	COG0436	Aminotransferase
DWB96_RS01950	COG2608	mercury ion transmembrane transporter activity
DWB96_RS01955	COG2217	Heavy metal translocating P-type atpase
DWB96_RS01970	COG1028	Short-chain dehydrogenase reductase Sdr
DWB96_RS01980	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DWB96_RS01985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DWB96_RS01990	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
DWB96_RS01995	COG1012	belongs to the aldehyde dehydrogenase family
DWB96_RS02030	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DWB96_RS02035	COG3425	synthase
DWB96_RS02055	COG0583	DNA-binding transcription factor activity
DWB96_RS02060	COG1380	Effector of murein hydrolase LrgA
DWB96_RS02065	COG1346	cytolysis
DWB96_RS02070	COG0028	Belongs to the TPP enzyme family
DWB96_RS02075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DWB96_RS02075	COG2190	(PTS) system
DWB96_RS02075	COG1263	PTS System
DWB96_RS02095	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DWB96_RS02100	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DWB96_RS02105	COG0657	acetylesterase activity
DWB96_RS02110	COG0697	spore germination
DWB96_RS02115	COG2207	Transcriptional regulator
DWB96_RS02115	COG1917	Cupin 2, conserved barrel domain protein
DWB96_RS02125	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DWB96_RS02135	COG2843	Capsule synthesis protein
DWB96_RS02150	COG4975	Glucose uptake
DWB96_RS02155	COG1869	D-ribose catabolic process
DWB96_RS02165	COG1070	Carbohydrate kinase
DWB96_RS02180	COG1760	l-serine dehydratase
DWB96_RS02185	COG1760	l-serine dehydratase
DWB96_RS02200	COG3764	Sortase (surface protein transpeptidase)
DWB96_RS02205	COG0561	phosphatase activity
DWB96_RS02210	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DWB96_RS02215	COG0778	Nitroreductase
DWB96_RS02220	COG1012	belongs to the aldehyde dehydrogenase family
DWB96_RS02225	COG2514	catechol 2,3-dioxygenase activity
DWB96_RS02240	COG1012	belongs to the aldehyde dehydrogenase family
DWB96_RS02245	COG3949	Membrane
DWB96_RS02255	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
DWB96_RS02260	COG0586	Pfam SNARE associated Golgi protein
DWB96_RS02265	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DWB96_RS02270	COG2022	thiamine diphosphate biosynthetic process
DWB96_RS02280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DWB96_RS02290	COG2271	Major facilitator Superfamily
DWB96_RS02305	COG4876	unkown
DWB96_RS02310	COG2357	RelA SpoT domain protein
DWB96_RS02325	COG1802	Transcriptional regulator
DWB96_RS02330	COG1070	Carbohydrate kinase
DWB96_RS02335	COG2610	gluconate transmembrane transporter activity
DWB96_RS02340	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DWB96_RS02345	COG1216	Glycosyl transferase, family 2
DWB96_RS02365	COG4221	oxidoreductase activity
DWB96_RS02370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DWB96_RS02375	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DWB96_RS02385	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
DWB96_RS02390	COG1028	Short-chain dehydrogenase reductase Sdr
DWB96_RS02400	COG1363	Peptidase, m42
DWB96_RS02405	COG4808	Protein conserved in bacteria
DWB96_RS02410	COG0069	glutamate synthase activity
DWB96_RS02425	COG4619	ABC transporter
DWB96_RS02430	COG0390	transport system, permease component
DWB96_RS02435	COG2205	protein histidine kinase activity
DWB96_RS02440	COG0745	RESPONSE REGULATOR receiver
DWB96_RS02450	COG2814	Major facilitator Superfamily
DWB96_RS02455	COG2272	Belongs to the type-B carboxylesterase lipase family
DWB96_RS02460	COG0531	amino acid
DWB96_RS02465	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
DWB96_RS02470	COG1063	alcohol dehydrogenase
DWB96_RS02490	COG1174	glycine betaine transport
DWB96_RS02495	COG1346	cytolysis
DWB96_RS02500	COG1380	Effector of murein hydrolase LrgA
DWB96_RS02510	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DWB96_RS02525	COG0706	membrane insertase activity
DWB96_RS02535	COG0531	amino acid
DWB96_RS02545	COG1113	amino acid transport
DWB96_RS02565	COG2814	Major facilitator Superfamily
DWB96_RS02575	COG1929	Belongs to the glycerate kinase type-1 family
DWB96_RS02590	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DWB96_RS02595	COG0588	phosphoglycerate mutase activity
DWB96_RS02605	COG2814	Major facilitator Superfamily
DWB96_RS02610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DWB96_RS02615	COG0765	amino acid transport
DWB96_RS02620	COG1126	abc transporter atp-binding protein
DWB96_RS02630	COG2348	transferase activity, transferring amino-acyl groups
DWB96_RS02660	COG2116	formate transmembrane transporter activity
DWB96_RS02665	COG0454	-acetyltransferase
DWB96_RS02670	COG0747	negative chemotaxis
DWB96_RS02675	COG2226	methyltransferase
DWB96_RS02685	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DWB96_RS02690	COG2146	nitrite reductase [NAD(P)H] activity
DWB96_RS02700	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
DWB96_RS02705	COG1140	nitrate reductase beta subunit
DWB96_RS02715	COG2181	nitrate reductase activity
DWB96_RS02725	COG4585	Histidine kinase
DWB96_RS02730	COG2197	response regulator
DWB96_RS02735	COG2223	nitrite transmembrane transporter activity
DWB96_RS02745	COG1846	Transcriptional regulator
DWB96_RS02750	COG0778	Nitroreductase
DWB96_RS02800	COG1028	Short-chain dehydrogenase reductase Sdr
DWB96_RS02810	COG0534	Mate efflux family protein
DWB96_RS02830	COG0492	ferredoxin-NADP+ reductase activity
DWB96_RS02845	COG2822	iron ion transport
DWB96_RS02855	COG0672	)-iron permease
DWB96_RS02860	COG0805	protein transport
DWB96_RS02865	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DWB96_RS02870	COG0456	acetyltransferase
DWB96_RS02875	COG0463	Glycosyl transferase, family 2
DWB96_RS02875	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DWB96_RS02885	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DWB96_RS02885	COG0463	Glycosyl transferase, family 2
DWB96_RS02890	COG1620	l-lactate permease
DWB96_RS02900	COG0579	oxidoreductase
DWB96_RS02905	COG3850	Histidine kinase
DWB96_RS02905	COG5002	protein histidine kinase activity
DWB96_RS02910	COG0745	RESPONSE REGULATOR receiver
DWB96_RS02915	COG0577	efflux transmembrane transporter activity
DWB96_RS02920	COG1136	(ABC) transporter
DWB96_RS02935	COG4640	response to antibiotic
DWB96_RS02940	COG2814	Major facilitator Superfamily
DWB96_RS02950	COG1566	PFAM secretion protein HlyD family protein
DWB96_RS02955	COG2814	Major facilitator Superfamily
DWB96_RS02980	COG0598	Magnesium transport protein CorA
DWB96_RS02985	COG1304	FMN binding
DWB96_RS02990	COG0786	glutamate:sodium symporter activity
DWB96_RS02995	COG2094	Belongs to the DNA glycosylase MPG family
DWB96_RS03000	COG3152	Membrane
DWB96_RS03015	COG1069	ribulokinase activity
DWB96_RS03020	COG4152	abc transporter atp-binding protein
DWB96_RS03025	COG1668	transmembrane transport
DWB96_RS03030	COG1742	UPF0060 membrane protein
DWB96_RS03035	COG2017	converts alpha-aldose to the beta-anomer
DWB96_RS03040	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DWB96_RS03045	COG1266	CAAX protease self-immunity
DWB96_RS03050	COG0010	Belongs to the arginase family
DWB96_RS03070	COG1473	amidohydrolase
DWB96_RS03075	COG1028	Short-chain dehydrogenase reductase Sdr
DWB96_RS03095	COG1737	Transcriptional regulator
DWB96_RS03100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DWB96_RS03100	COG1263	PTS System
DWB96_RS03110	COG0385	Bile acid
DWB96_RS03115	COG0546	phosphoglycolate phosphatase activity
DWB96_RS03135	COG1113	amino acid transport
DWB96_RS03145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DWB96_RS03145	COG1263	PTS System
DWB96_RS03150	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DWB96_RS03170	COG2378	regulation of single-species biofilm formation
DWB96_RS03180	COG1316	TRANSCRIPTIONal
DWB96_RS03210	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DWB96_RS03215	COG2076	Multidrug Resistance protein
DWB96_RS03220	COG2076	Multidrug Resistance protein
DWB96_RS03225	COG3942	CHAP domain
DWB96_RS03240	COG1757	Na H antiporter
DWB96_RS03245	COG3942	CHAP domain
DWB96_RS03255	COG1846	Transcriptional regulator
DWB96_RS03270	COG0829	nickel cation binding
DWB96_RS03280	COG0830	nickel cation binding
DWB96_RS03285	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
DWB96_RS03290	COG0804	urea catabolic process
DWB96_RS03295	COG0832	Belongs to the urease beta subunit family
DWB96_RS03300	COG0831	urea catabolic process
DWB96_RS03305	COG4413	Urea transporter
DWB96_RS03310	COG1960	acyl-CoA dehydrogenase activity
DWB96_RS03315	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DWB96_RS03325	COG1268	BioY protein
DWB96_RS03335	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DWB96_RS03340	COG0725	ABC transporter, periplasmic molybdate-binding protein
DWB96_RS03345	COG4149	molybdate abc transporter
DWB96_RS03350	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DWB96_RS03355	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DWB96_RS03360	COG0521	Mo-molybdopterin cofactor biosynthetic process
DWB96_RS03365	COG0315	cyclic pyranopterin monophosphate synthase activity
DWB96_RS03370	COG0303	'Molybdopterin
DWB96_RS03390	COG0746	molybdenum cofactor guanylyltransferase activity
DWB96_RS03395	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DWB96_RS03405	COG2814	Major facilitator Superfamily
DWB96_RS03425	COG2348	transferase activity, transferring amino-acyl groups
DWB96_RS03430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DWB96_RS03450	COG4975	Glucose uptake
DWB96_RS03460	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DWB96_RS03460	COG0551	DNA topoisomerase type I activity
DWB96_RS03465	COG2252	PERMEase
DWB96_RS03480	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DWB96_RS03485	COG0088	Forms part of the polypeptide exit tunnel
DWB96_RS03490	COG0089	rRNA binding
DWB96_RS03495	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DWB96_RS03500	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DWB96_RS03515	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DWB96_RS03525	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DWB96_RS03530	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DWB96_RS03535	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DWB96_RS03540	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DWB96_RS03545	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DWB96_RS03550	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DWB96_RS03555	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DWB96_RS03560	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DWB96_RS03565	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DWB96_RS03570	COG1841	ribosomal large subunit assembly
DWB96_RS03575	COG0200	Binds to the 23S rRNA
DWB96_RS03580	COG0201	protein transport
DWB96_RS03585	COG0563	adenylate kinase activity
DWB96_RS03590	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DWB96_RS03595	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DWB96_RS03600	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DWB96_RS03610	COG0202	RNA polymerase activity
DWB96_RS03615	COG0203	ribosomal protein L17
DWB96_RS03620	COG1122	ATPase activity
DWB96_RS03625	COG1122	ATPase activity
DWB96_RS03635	COG0101	tRNA pseudouridine synthase activity
DWB96_RS03640	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DWB96_RS03650	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DWB96_RS03655	COG1349	DNA-binding transcription factor activity
DWB96_RS03660	COG0698	ribose 5-phosphate isomerase
DWB96_RS03685	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DWB96_RS03685	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DWB96_RS03690	COG2723	6-phospho-beta-galactosidase activity
DWB96_RS03700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWB96_RS03705	COG2130	NADP-dependent
DWB96_RS03710	COG0604	alcohol dehydrogenase
DWB96_RS03725	COG1302	Protein conserved in bacteria
DWB96_RS03730	COG4264	IucA IucC family
DWB96_RS03735	COG2814	Major facilitator Superfamily
DWB96_RS03740	COG4264	IucA IucC family
DWB96_RS03745	COG3457	Alanine racemase
DWB96_RS03750	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DWB96_RS03755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWB96_RS03760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWB96_RS03765	COG3314	Sporulation integral membrane protein YlbJ
DWB96_RS03770	COG2329	Antibiotic biosynthesis monooxygenase
DWB96_RS03780	COG1988	membrane-bound metal-dependent
DWB96_RS03785	COG4284	Utp--glucose-1-phosphate uridylyltransferase
DWB96_RS03805	COG2814	Major facilitator Superfamily
DWB96_RS03810	COG0489	protein tyrosine kinase activity
DWB96_RS03865	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DWB96_RS03875	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DWB96_RS03890	COG3711	transcriptional antiterminator
DWB96_RS03900	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DWB96_RS03905	COG0561	phosphatase activity
DWB96_RS03925	COG0640	Transcriptional regulator
DWB96_RS03930	COG0702	epimerase
DWB96_RS03935	COG1482	cell wall glycoprotein biosynthetic process
DWB96_RS03955	COG0783	Belongs to the Dps family
DWB96_RS03960	COG0813	purine-nucleoside phosphorylase activity
DWB96_RS03965	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DWB96_RS03970	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DWB96_RS03975	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
DWB96_RS03985	COG1854	S-ribosylhomocysteine lyase activity
DWB96_RS04005	COG5146	pantothenate kinase activity
DWB96_RS04010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DWB96_RS04015	COG3343	RNA polymerase activity
DWB96_RS04020	COG0504	CTP synthase activity
DWB96_RS04035	COG0191	fructose-bisphosphate aldolase activity
DWB96_RS04040	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DWB96_RS04050	COG1012	belongs to the aldehyde dehydrogenase family
DWB96_RS04055	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DWB96_RS04060	COG0254	rRNA binding
DWB96_RS04065	COG1435	thymidine kinase activity
DWB96_RS04075	COG2890	protein-(glutamine-N5) methyltransferase activity
DWB96_RS04080	COG0009	L-threonylcarbamoyladenylate synthase
DWB96_RS04085	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DWB96_RS04090	COG4475	Protein of unknown function (DUF436)
DWB96_RS04095	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DWB96_RS04100	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DWB96_RS04105	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DWB96_RS04115	COG0356	it plays a direct role in the translocation of protons across the membrane
DWB96_RS04125	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DWB96_RS04130	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DWB96_RS04135	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DWB96_RS04140	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DWB96_RS04145	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DWB96_RS04150	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DWB96_RS04165	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DWB96_RS04175	COG0629	single-stranded DNA binding
DWB96_RS04180	COG1388	LysM domain
DWB96_RS04185	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DWB96_RS04195	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DWB96_RS04200	COG0352	thiamine-phosphate diphosphorylase activity
DWB96_RS04205	COG0706	membrane insertase activity
DWB96_RS04210	COG1418	mRNA catabolic process
DWB96_RS04215	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DWB96_RS04220	COG1937	Protein conserved in bacteria
DWB96_RS04235	COG0772	Belongs to the SEDS family
DWB96_RS04240	COG1181	Belongs to the D-alanine--D-alanine ligase family
DWB96_RS04245	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DWB96_RS04250	COG0513	Belongs to the DEAD box helicase family
DWB96_RS04265	COG3402	PFAM membrane-flanked domain
DWB96_RS04270	COG0736	holo-[acyl-carrier-protein] synthase activity
DWB96_RS04275	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DWB96_RS04285	COG2337	Toxic component of a toxin-antitoxin (TA) module
DWB96_RS04290	COG2208	phosphoserine phosphatase activity
DWB96_RS04305	COG1191	sigma factor activity
DWB96_RS04310	COG2183	response to ionizing radiation
DWB96_RS04315	COG3091	SprT-like family
DWB96_RS04355	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DWB96_RS04360	COG0473	3-isopropylmalate dehydrogenase activity
DWB96_RS04365	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DWB96_RS04370	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DWB96_RS04380	COG0028	Belongs to the TPP enzyme family
DWB96_RS04385	COG0129	dihydroxy-acid dehydratase activity
DWB96_RS04390	COG0802	atpase or kinase
DWB96_RS04395	COG1214	PFAM Peptidase M22, glycoprotease
DWB96_RS04400	COG0456	acetyltransferase
DWB96_RS04405	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DWB96_RS04410	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DWB96_RS04415	COG0488	(ABC) transporter
DWB96_RS04420	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DWB96_RS04430	COG2391	methyltransferase activity
DWB96_RS04435	COG0425	Belongs to the sulfur carrier protein TusA family
DWB96_RS04440	COG0004	ammonium transporteR
DWB96_RS04445	COG1621	beta-fructofuranosidase activity
DWB96_RS04450	COG3279	Response regulator of the LytR AlgR family
DWB96_RS04495	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DWB96_RS04500	COG0459	protein refolding
DWB96_RS04505	COG0582	viral genome integration into host DNA
DWB96_RS04570	COG5484	DNA packaging
DWB96_RS04570	COG3728	DNA packaging
DWB96_RS04580	COG1846	Transcriptional regulator
DWB96_RS04595	COG0693	protein deglycase activity
DWB96_RS04605	COG0346	lactoylglutathione lyase activity
DWB96_RS04630	COG1725	Transcriptional regulator
DWB96_RS04645	COG1131	(ABC) transporter
DWB96_RS04690	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DWB96_RS04695	COG2706	6-phosphogluconolactonase activity
DWB96_RS04700	COG1012	belongs to the aldehyde dehydrogenase family
DWB96_RS04705	COG1227	inorganic diphosphatase activity
DWB96_RS04710	COG1335	isochorismatase
DWB96_RS04720	COG0077	Prephenate dehydratase
DWB96_RS04730	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DWB96_RS04735	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DWB96_RS04740	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
DWB96_RS04755	COG4496	protein, YerC YecD
DWB96_RS04760	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
DWB96_RS04765	COG0210	DNA helicase
DWB96_RS04770	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DWB96_RS04780	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DWB96_RS04785	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DWB96_RS04790	COG0154	amidase activity
DWB96_RS04795	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DWB96_RS04800	COG1597	lipid kinase activity
DWB96_RS04805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DWB96_RS04835	COG2946	Replication initiation factor
DWB96_RS04855	COG0433	COG0433 Predicted ATPase
DWB96_RS04865	COG1674	ftsk spoiiie
DWB96_RS04875	COG5644	endopeptidase inhibitor activity
DWB96_RS04900	COG2826	transposase and inactivated derivatives, IS30 family
DWB96_RS04910	COG1528	Iron-storage protein
DWB96_RS04930	COG4129	membrane
DWB96_RS04935	COG0024	Methionine aminopeptidase
DWB96_RS04955	COG2197	response regulator
DWB96_RS04960	COG1295	ribonuclease BN
DWB96_RS04970	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DWB96_RS04975	COG4840	Belongs to the UPF0435 family
DWB96_RS04980	COG2309	aminopeptidase activity
DWB96_RS04985	COG1607	acyl-coa hydrolase
DWB96_RS04990	COG0535	radical SAM domain protein
DWB96_RS05000	COG0693	protein deglycase activity
DWB96_RS05005	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DWB96_RS05010	COG2137	regulation of response to DNA damage stimulus
DWB96_RS05020	COG1134	teichoic acid transport
DWB96_RS05020	COG1388	LysM domain
DWB96_RS05030	COG1988	membrane-bound metal-dependent
DWB96_RS05040	COG3557	Belongs to the UPF0374 family
DWB96_RS05050	COG4129	membrane
DWB96_RS05055	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DWB96_RS05060	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DWB96_RS05065	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DWB96_RS05070	COG0735	belongs to the Fur family
DWB96_RS05245	COG0765	amino acid transport
DWB96_RS05250	COG1126	abc transporter atp-binding protein
DWB96_RS05255	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DWB96_RS05265	COG0363	glucosamine-6-phosphate deaminase activity
DWB96_RS05280	COG0114	fumarate hydratase activity
DWB96_RS05285	COG0564	pseudouridine synthase activity
DWB96_RS05290	COG4585	Histidine kinase
DWB96_RS05290	COG2203	Gaf domain
DWB96_RS05295	COG2197	response regulator
DWB96_RS05305	COG4399	Belongs to the UPF0754 family
DWB96_RS05310	COG3679	Belongs to the UPF0342 family
DWB96_RS05315	COG0420	3'-5' exonuclease activity
DWB96_RS05325	COG3481	metal-dependent phosphohydrolase, HD sub domain
DWB96_RS05335	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DWB96_RS05350	COG0537	adenosine 5'-monophosphoramidase activity
DWB96_RS05355	COG1131	(ABC) transporter
DWB96_RS05360	COG4473	ABC transporter
DWB96_RS05365	COG2329	Antibiotic biosynthesis monooxygenase
DWB96_RS05370	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DWB96_RS05375	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DWB96_RS05380	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DWB96_RS05385	COG3545	Serine hydrolase
DWB96_RS05435	COG0318	PFAM AMP-dependent synthetase and ligase
DWB96_RS05450	COG0494	nUDIX hydrolase
DWB96_RS05455	COG1506	peptidase
DWB96_RS05465	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DWB96_RS05475	COG0656	L-ascorbic acid biosynthetic process
DWB96_RS05480	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DWB96_RS05485	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DWB96_RS05495	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DWB96_RS05520	COG4193	domain, Protein
DWB96_RS05520	COG5632	N-Acetylmuramoyl-L-alanine amidase
DWB96_RS05520	COG3266	domain, Protein
DWB96_RS05530	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DWB96_RS05530	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DWB96_RS05540	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DWB96_RS05540	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DWB96_RS05545	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DWB96_RS05550	COG0506	proline dehydrogenase activity
DWB96_RS05555	COG2267	carboxylic ester hydrolase activity
DWB96_RS05565	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DWB96_RS05570	COG1242	4 iron, 4 sulfur cluster binding
DWB96_RS05575	COG2814	Major facilitator Superfamily
DWB96_RS05580	COG0495	leucyl-tRNA aminoacylation
DWB96_RS05595	COG2081	HI0933 family
DWB96_RS05600	COG2244	polysaccharide biosynthetic process
DWB96_RS05605	COG1187	pseudouridine synthase activity
DWB96_RS05615	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DWB96_RS05620	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DWB96_RS05625	COG0510	thiamine kinase activity
DWB96_RS05630	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DWB96_RS05635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DWB96_RS05645	COG1363	Peptidase, m42
DWB96_RS05650	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DWB96_RS05655	COG4848	Belongs to the UPF0354 family
DWB96_RS05660	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DWB96_RS05665	COG1674	ftsk spoiiie
DWB96_RS05670	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DWB96_RS05675	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
DWB96_RS05685	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DWB96_RS05685	COG1605	Chorismate mutase
DWB96_RS05690	COG1609	Transcriptional regulator
DWB96_RS05700	COG0454	-acetyltransferase
DWB96_RS05705	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DWB96_RS05710	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DWB96_RS05720	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DWB96_RS05730	COG0477	Major facilitator Superfamily
DWB96_RS05735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DWB96_RS05740	COG0204	Acyl-transferase
DWB96_RS05745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DWB96_RS05745	COG1263	PTS System
DWB96_RS05755	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DWB96_RS05765	COG1764	response to oxidative stress
DWB96_RS05770	COG0584	glycerophosphoryl diester phosphodiesterase
DWB96_RS05775	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DWB96_RS05785	COG1956	GAF domain-containing protein
DWB96_RS05790	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
DWB96_RS05795	COG1104	cysteine desulfurase activity
DWB96_RS05800	COG0301	tRNA thio-modification
DWB96_RS05810	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DWB96_RS05815	COG0827	DNA restriction-modification system
DWB96_RS05820	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DWB96_RS05825	COG0589	response to stress
DWB96_RS05835	COG0006	proline dipeptidase activity
DWB96_RS05840	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DWB96_RS05850	COG4109	DRTGG domain
DWB96_RS05855	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DWB96_RS05860	COG0587	DNA-directed DNA polymerase activity
DWB96_RS05865	COG0281	malic enzyme
DWB96_RS05870	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DWB96_RS05880	COG0205	6-phosphofructokinase activity
DWB96_RS05885	COG0469	pyruvate kinase activity
DWB96_RS05890	COG1113	amino acid transport
DWB96_RS05895	COG0372	Belongs to the citrate synthase family
DWB96_RS05900	COG0538	isocitrate dehydrogenase activity
DWB96_RS05905	COG0745	RESPONSE REGULATOR receiver
DWB96_RS05910	COG5002	protein histidine kinase activity
DWB96_RS05915	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DWB96_RS05915	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DWB96_RS05920	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DWB96_RS05925	COG0237	dephospho-CoA kinase activity
DWB96_RS05930	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DWB96_RS05935	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DWB96_RS05940	COG3611	Membrane attachment protein
DWB96_RS05945	COG1484	DNA-dependent DNA replication
DWB96_RS05950	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DWB96_RS05955	COG0833	amino acid
DWB96_RS05960	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DWB96_RS05965	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DWB96_RS05970	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DWB96_RS05975	COG4112	unkown
DWB96_RS05985	COG0544	peptidyl-prolyl cis-trans isomerase activity
DWB96_RS05990	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DWB96_RS05995	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DWB96_RS06000	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DWB96_RS06005	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DWB96_RS06010	COG0181	hydroxymethylbilane synthase activity
DWB96_RS06020	COG0113	porphobilinogen synthase activity
DWB96_RS06025	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DWB96_RS06035	COG2818	Glycosylase
DWB96_RS06045	COG0285	dihydrofolate synthase activity
DWB96_RS06055	COG2003	Belongs to the UPF0758 family
DWB96_RS06080	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DWB96_RS06085	COG2868	ribosomal protein
DWB96_RS06090	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DWB96_RS06095	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DWB96_RS06100	COG4492	Belongs to the UPF0735 family
DWB96_RS06105	COG0632	four-way junction helicase activity
DWB96_RS06110	COG2255	four-way junction helicase activity
DWB96_RS06120	COG0343	queuine tRNA-ribosyltransferase activity
DWB96_RS06125	COG1862	Preprotein translocase
DWB96_RS06130	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DWB96_RS06130	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DWB96_RS06145	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DWB96_RS06150	COG1490	D-aminoacyl-tRNA deacylase activity
DWB96_RS06155	COG0860	N-Acetylmuramoyl-L-alanine amidase
DWB96_RS06165	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DWB96_RS06175	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DWB96_RS06180	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DWB96_RS06185	COG1959	2 iron, 2 sulfur cluster binding
DWB96_RS06200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWB96_RS06205	COG1104	cysteine desulfurase activity
DWB96_RS06210	COG0482	sulfurtransferase activity
DWB96_RS06220	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DWB96_RS06225	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DWB96_RS06230	COG4472	Bacterial protein of unknown function (DUF965)
DWB96_RS06235	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DWB96_RS06240	COG3906	Belongs to the UPF0473 family
DWB96_RS06250	COG0826	peptidase U32
DWB96_RS06255	COG0826	peptidase U32
DWB96_RS06260	COG0572	uridine kinase
DWB96_RS06265	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DWB96_RS06270	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DWB96_RS06275	COG1984	allophanate hydrolase subunit 2
DWB96_RS06280	COG0511	ligase activity, forming carbon-carbon bonds
DWB96_RS06285	COG0439	Biotin carboxylase
DWB96_RS06290	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DWB96_RS06295	COG1914	H( )-stimulated, divalent metal cation uptake system
DWB96_RS06300	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DWB96_RS06305	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
DWB96_RS06310	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DWB96_RS06320	COG1534	Rna-binding protein
DWB96_RS06325	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DWB96_RS06330	COG1713	HD superfamily hydrolase involved in NAD metabolism
DWB96_RS06335	COG0799	negative regulation of ribosome biogenesis
DWB96_RS06340	COG4106	trans-aconitate 2-methyltransferase activity
DWB96_RS06345	COG1555	photosystem II stabilization
DWB96_RS06345	COG1596	polysaccharide export
DWB96_RS06350	COG2131	deaminase
DWB96_RS06355	COG2333	competence protein COMEC
DWB96_RS06355	COG0658	competence protein
DWB96_RS06360	COG1466	dna polymerase III delta subunit
DWB96_RS06365	COG0268	Binds directly to 16S ribosomal RNA
DWB96_RS06370	COG0481	GTPase activity
DWB96_RS06375	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DWB96_RS06380	COG1420	regulation of RNA biosynthetic process
DWB96_RS06385	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DWB96_RS06390	COG0443	Heat shock 70 kDa protein
DWB96_RS06395	COG0484	heat shock protein binding
DWB96_RS06400	COG2264	protein methyltransferase activity
DWB96_RS06405	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DWB96_RS06410	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DWB96_RS06420	COG1030	water channel activity
DWB96_RS06425	COG4864	UPF0365 protein
DWB96_RS06435	COG1702	phosphate starvation-inducible protein PhoH
DWB96_RS06440	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DWB96_RS06455	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DWB96_RS06460	COG1381	Involved in DNA repair and RecF pathway recombination
DWB96_RS06465	COG0423	glycine-tRNA ligase activity
DWB96_RS06470	COG0517	IMP dehydrogenase activity
DWB96_RS06475	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DWB96_RS06480	COG0358	DNA primase activity
DWB96_RS06485	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DWB96_RS06490	COG2384	SAM-dependent methyltransferase
DWB96_RS06495	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DWB96_RS06500	COG0513	Belongs to the DEAD box helicase family
DWB96_RS06505	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DWB96_RS06510	COG1121	(ABC) transporter
DWB96_RS06515	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DWB96_RS06530	COG0768	penicillin binding
DWB96_RS06535	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DWB96_RS06540	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DWB96_RS06545	COG0457	Tetratricopeptide repeat
DWB96_RS06545	COG0705	Rhomboid family
DWB96_RS06550	COG4483	Protein conserved in bacteria
DWB96_RS06555	COG1940	carbohydrate kinase activity
DWB96_RS06560	COG0011	TIGRFAM Protein of
DWB96_RS06565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DWB96_RS06570	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DWB96_RS06575	COG1459	type II secretion system
DWB96_RS06580	COG4537	Required for transformation and DNA binding
DWB96_RS06605	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DWB96_RS06610	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DWB96_RS06615	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DWB96_RS06620	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DWB96_RS06625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DWB96_RS06630	COG0095	Lipoate-protein ligase
DWB96_RS06645	COG0006	proline dipeptidase activity
DWB96_RS06650	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DWB96_RS06655	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DWB96_RS06660	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DWB96_RS06665	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DWB96_RS06675	COG0511	ligase activity, forming carbon-carbon bonds
DWB96_RS06680	COG0439	Biotin carboxylase
DWB96_RS06685	COG1302	Protein conserved in bacteria
DWB96_RS06690	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DWB96_RS06695	COG1570	exodeoxyribonuclease VII activity
DWB96_RS06705	COG0142	geranyltranstransferase activity
DWB96_RS06710	COG1438	arginine binding
DWB96_RS06715	COG0497	DNA recombination
DWB96_RS06720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DWB96_RS06725	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DWB96_RS06730	COG0022	dehydrogenase e1 component
DWB96_RS06735	COG0508	dehydrogenase complex catalyzes the overall conversion of
DWB96_RS06745	COG4129	membrane
DWB96_RS06750	COG2195	Cleaves the N-terminal amino acid of tripeptides
DWB96_RS06755	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DWB96_RS06765	COG0366	Alpha amylase catalytic
DWB96_RS06775	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DWB96_RS06780	COG1234	tRNA 3'-trailer cleavage
DWB96_RS06785	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DWB96_RS06790	COG0300	oxidoreductase activity
DWB96_RS06795	COG0667	Aldo Keto reductase
DWB96_RS06800	COG0494	nUDIX hydrolase
DWB96_RS06805	COG0735	belongs to the Fur family
DWB96_RS06810	COG4974	Belongs to the 'phage' integrase family
DWB96_RS06820	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DWB96_RS06825	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DWB96_RS06830	COG1187	pseudouridine synthase activity
DWB96_RS06835	COG0745	RESPONSE REGULATOR receiver
DWB96_RS06850	COG1141	Ferredoxin
DWB96_RS06860	COG0514	ATP-dependent DNA helicase (RecQ)
DWB96_RS06865	COG1388	LysM domain
DWB96_RS06865	COG1388	LysM domain
DWB96_RS06870	COG0492	ferredoxin-NADP+ reductase activity
DWB96_RS06875	COG0252	asparaginase activity
DWB96_RS06880	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DWB96_RS06885	COG0539	negative regulation of cytoplasmic translation
DWB96_RS06890	COG1160	GTP binding
DWB96_RS06895	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DWB96_RS06910	COG2226	methyltransferase
DWB96_RS06920	COG0105	UTP biosynthetic process
DWB96_RS06925	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DWB96_RS06930	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DWB96_RS06935	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DWB96_RS06945	COG5582	Belongs to the UPF0302 family
DWB96_RS06950	COG4347	Protein of unknown function (DUF1405)
DWB96_RS06955	COG2738	Putative neutral zinc metallopeptidase
DWB96_RS06960	COG1694	Mazg nucleotide pyrophosphohydrolase
DWB96_RS06965	COG0438	transferase activity, transferring glycosyl groups
DWB96_RS06970	COG0617	tRNA 3'-terminal CCA addition
DWB96_RS06975	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DWB96_RS06975	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DWB96_RS06980	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DWB96_RS06980	COG1199	ATP-dependent helicase activity
DWB96_RS06985	COG0017	Asparaginyl-tRNA synthetase
DWB96_RS06990	COG3935	DnaD domain protein
DWB96_RS06995	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DWB96_RS07005	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DWB96_RS07005	COG4499	WXG100 protein secretion system (Wss), protein YukC
DWB96_RS07010	COG3331	DNA recombination
DWB96_RS07020	COG4474	Belongs to the UPF0398 family
DWB96_RS07025	COG3599	regulation of cell shape
DWB96_RS07035	COG0116	Belongs to the methyltransferase superfamily
DWB96_RS07045	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DWB96_RS07050	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DWB96_RS07065	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DWB96_RS07075	COG1413	lyase activity
DWB96_RS07080	COG1413	lyase activity
DWB96_RS07110	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DWB96_RS07115	COG2190	(PTS) system
DWB96_RS07120	COG4479	Belongs to the UPF0346 family
DWB96_RS07125	COG0793	Belongs to the peptidase S41A family
DWB96_RS07135	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DWB96_RS07140	COG0671	phosphoesterase, PA-phosphatase related
DWB96_RS07145	COG3842	ATPase activity
DWB96_RS07150	COG4209	transmembrane transport
DWB96_RS07160	COG0395	ABC-type sugar transport system, permease component
DWB96_RS07170	COG0534	Mate efflux family protein
DWB96_RS07175	COG1349	DNA-binding transcription factor activity
DWB96_RS07180	COG0745	RESPONSE REGULATOR receiver
DWB96_RS07185	COG5002	protein histidine kinase activity
DWB96_RS07190	COG0567	Dehydrogenase, E1 component
DWB96_RS07200	COG0582	viral genome integration into host DNA
DWB96_RS07240	COG0582	viral genome integration into host DNA
DWB96_RS07285	COG3177	Filamentation induced by cAMP protein fic
DWB96_RS07290	COG1131	(ABC) transporter
DWB96_RS07315	COG0714	Associated with various cellular activities
DWB96_RS07320	COG4548	von Willebrand factor, type A
DWB96_RS07325	COG1114	Component of the transport system for branched-chain amino acids
DWB96_RS07330	COG3853	Toxic anion resistance protein (TelA)
DWB96_RS07340	COG1254	Belongs to the acylphosphatase family
DWB96_RS07350	COG1278	Cold shock
DWB96_RS07365	COG1473	amidohydrolase
DWB96_RS07370	COG2171	N-acyltransferase activity
DWB96_RS07375	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DWB96_RS07380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DWB96_RS07385	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DWB96_RS07390	COG0527	aspartate kinase activity
DWB96_RS07395	COG0488	(ABC) transporter
DWB96_RS07400	COG2996	Protein conserved in bacteria
DWB96_RS07420	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DWB96_RS07425	COG0573	inorganic phosphate transmembrane transporter activity
DWB96_RS07430	COG0581	inorganic phosphate transmembrane transporter activity
DWB96_RS07435	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DWB96_RS07440	COG0704	Plays a role in the regulation of phosphate uptake
DWB96_RS07445	COG1164	Oligoendopeptidase f
DWB96_RS07480	COG2348	transferase activity, transferring amino-acyl groups
DWB96_RS07485	COG2348	transferase activity, transferring amino-acyl groups
DWB96_RS07495	COG0159	tryptophan synthase activity
DWB96_RS07500	COG0133	tryptophan synthase activity
DWB96_RS07505	COG0135	phosphoribosylanthranilate isomerase activity
DWB96_RS07510	COG0134	indole-3-glycerol-phosphate synthase activity
DWB96_RS07515	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DWB96_RS07520	COG0512	Glutamine amidotransferase of anthranilate synthase
DWB96_RS07525	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DWB96_RS07530	COG1363	Peptidase, m42
DWB96_RS07535	COG0287	Prephenate dehydrogenase
DWB96_RS07540	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DWB96_RS07545	COG1942	4-Oxalocrotonate Tautomerase
DWB96_RS07560	COG0392	lysyltransferase activity
DWB96_RS07560	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DWB96_RS07565	COG0628	permease
DWB96_RS07570	COG3711	transcriptional antiterminator
DWB96_RS07575	COG1115	amino acid carrier protein
DWB96_RS07580	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DWB96_RS07585	COG0187	DNA topoisomerase II activity
DWB96_RS07590	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DWB96_RS07600	COG0824	Thioesterase
DWB96_RS07605	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DWB96_RS07610	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DWB96_RS07615	COG1970	mechanosensitive ion channel activity
DWB96_RS07620	COG0419	ATPase involved in DNA repair
DWB96_RS07625	COG0420	3'-5' exonuclease activity
DWB96_RS07630	COG4846	Membrane protein involved in cytochrome C biogenesis
DWB96_RS07635	COG3763	UPF0154 protein
DWB96_RS07640	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DWB96_RS07645	COG4224	UPF0291 protein
DWB96_RS07655	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DWB96_RS07660	COG2340	Cysteine-rich secretory protein family
DWB96_RS07665	COG0516	GMP reductase activity
DWB96_RS07670	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DWB96_RS07685	COG0833	amino acid
DWB96_RS07700	COG0083	homoserine kinase activity
DWB96_RS07705	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DWB96_RS07710	COG0460	homoserine dehydrogenase
DWB96_RS07715	COG0527	aspartate kinase activity
DWB96_RS07730	COG1525	nuclease
DWB96_RS07745	COG2197	response regulator
DWB96_RS07750	COG4585	Histidine kinase
DWB96_RS07760	COG1131	(ABC) transporter
DWB96_RS07765	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DWB96_RS07820	COG0174	glutamine synthetase
DWB96_RS07825	COG0789	Transcriptional regulator
DWB96_RS07830	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
DWB96_RS07835	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DWB96_RS07840	COG0386	Belongs to the glutathione peroxidase family
DWB96_RS07845	COG1923	regulation of RNA biosynthetic process
DWB96_RS07850	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DWB96_RS07860	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DWB96_RS07865	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DWB96_RS07870	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DWB96_RS07875	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
DWB96_RS07880	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DWB96_RS07885	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DWB96_RS07895	COG4550	Control of competence regulator ComK, YlbF/YmcA
DWB96_RS07900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DWB96_RS07910	COG4195	phage-related replication protein
DWB96_RS07915	COG1013	pyruvate-flavodoxin oxidoreductase activity
DWB96_RS07920	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DWB96_RS07920	COG0674	pyruvate-flavodoxin oxidoreductase activity
DWB96_RS07925	COG1692	metallophosphoesterase
DWB96_RS07935	COG1418	mRNA catabolic process
DWB96_RS07940	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DWB96_RS07945	COG1546	Belongs to the CinA family
DWB96_RS07945	COG1058	Belongs to the CinA family
DWB96_RS07950	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DWB96_RS07965	COG0300	oxidoreductase activity
DWB96_RS07970	COG0612	Peptidase, M16
DWB96_RS07975	COG0612	Peptidase, M16
DWB96_RS07980	COG2188	Transcriptional regulator
DWB96_RS07985	COG1674	ftsk spoiiie
DWB96_RS07990	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DWB96_RS07995	COG1185	polyribonucleotide nucleotidyltransferase activity
DWB96_RS08000	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DWB96_RS08005	COG0196	riboflavin kinase activity
DWB96_RS08010	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DWB96_RS08015	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DWB96_RS08020	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DWB96_RS08030	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DWB96_RS08035	COG0195	Participates in both transcription termination and antitermination
DWB96_RS08040	COG0779	Required for maturation of 30S ribosomal subunits
DWB96_RS08045	COG2176	DNA-directed DNA polymerase activity
DWB96_RS08050	COG0442	prolyl-tRNA aminoacylation
DWB96_RS08060	COG4589	Belongs to the CDS family
DWB96_RS08065	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DWB96_RS08070	COG0233	cytoplasmic translational termination
DWB96_RS08075	COG0528	UMP kinase activity
DWB96_RS08080	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DWB96_RS08085	COG0052	Belongs to the universal ribosomal protein uS2 family
DWB96_RS08100	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DWB96_RS08105	COG4974	Belongs to the 'phage' integrase family
DWB96_RS08110	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DWB96_RS08115	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DWB96_RS08120	COG0758	DNA mediated transformation
DWB96_RS08125	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DWB96_RS08130	COG0045	succinate-CoA ligase (ADP-forming) activity
DWB96_RS08135	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DWB96_RS08145	COG4485	Bacterial membrane protein, YfhO
DWB96_RS08155	COG0335	large ribosomal subunit rRNA binding
DWB96_RS08160	COG0336	Belongs to the RNA methyltransferase TrmD family
DWB96_RS08165	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DWB96_RS08170	COG0228	four-way junction DNA binding
DWB96_RS08175	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DWB96_RS08180	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
DWB96_RS08185	COG0552	protein localization to endoplasmic reticulum
DWB96_RS08190	COG1196	nuclear chromosome segregation
DWB96_RS08195	COG0571	ribonuclease III activity
DWB96_RS08200	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DWB96_RS08215	COG0416	fatty acid biosynthetic process
DWB96_RS08220	COG1349	DNA-binding transcription factor activity
DWB96_RS08225	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DWB96_RS08240	COG1461	Dihydroxyacetone kinase
DWB96_RS08245	COG1302	Protein conserved in bacteria
DWB96_RS08250	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DWB96_RS08255	COG1564	THIamine pyrophosphokinase
DWB96_RS08260	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DWB96_RS08265	COG1162	GTPase activity
DWB96_RS08270	COG2807	transmembrane transport
DWB96_RS08280	COG0631	protein serine/threonine phosphatase activity
DWB96_RS08285	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DWB96_RS08290	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DWB96_RS08290	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DWB96_RS08295	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DWB96_RS08300	COG0242	peptide deformylase activity
DWB96_RS08315	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DWB96_RS08320	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DWB96_RS08325	COG1758	RNA polymerase activity
DWB96_RS08330	COG0194	GDP metabolic process
DWB96_RS08335	COG1293	RNA-binding protein homologous to eukaryotic snRNP
DWB96_RS08350	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DWB96_RS08355	COG0284	orotidine-5'-phosphate decarboxylase activity
DWB96_RS08360	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DWB96_RS08365	COG0505	Belongs to the CarA family
DWB96_RS08370	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DWB96_RS08375	COG0540	Belongs to the ATCase OTCase family
DWB96_RS08380	COG2233	PERMEase
DWB96_RS08385	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DWB96_RS08390	COG0564	pseudouridine synthase activity
DWB96_RS08395	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DWB96_RS08410	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DWB96_RS08415	COG3599	regulation of cell shape
DWB96_RS08425	COG0762	integral membrane protein
DWB96_RS08430	COG1799	cell septum assembly
DWB96_RS08435	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DWB96_RS08440	COG1496	oxidoreductase activity
DWB96_RS08445	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DWB96_RS08450	COG0849	cell division
DWB96_RS08455	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DWB96_RS08460	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DWB96_RS08465	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DWB96_RS08470	COG0768	penicillin binding
DWB96_RS08475	COG4839	cell division protein FtsL
DWB96_RS08480	COG0275	rRNA processing
DWB96_RS08490	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
DWB96_RS08495	COG0454	-acetyltransferase
DWB96_RS08500	COG1011	Hydrolase
DWB96_RS08540	COG0860	N-Acetylmuramoyl-L-alanine amidase
DWB96_RS08540	COG1388	LysM domain
DWB96_RS08575	COG5434	Belongs to the glycosyl hydrolase 28 family
DWB96_RS08595	COG3953	SLT domain
DWB96_RS08595	COG5280	Phage tail tape measure protein TP901
DWB96_RS08680	COG0756	dUTP diphosphatase activity
DWB96_RS08745	COG1484	DNA-dependent DNA replication
DWB96_RS08815	COG3561	AntA/AntB antirepressor
DWB96_RS08825	COG1396	sequence-specific DNA binding
DWB96_RS08845	COG0582	viral genome integration into host DNA
DWB96_RS08855	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DWB96_RS08860	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DWB96_RS08865	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DWB96_RS08870	COG1053	succinate dehydrogenase
DWB96_RS08875	COG2009	succinate dehydrogenase
DWB96_RS08880	COG0322	excinuclease ABC activity
DWB96_RS08885	COG3118	belongs to the thioredoxin family
DWB96_RS08890	COG1193	negative regulation of DNA recombination
DWB96_RS08895	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DWB96_RS08895	COG1796	DNA polymerase
DWB96_RS08905	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
DWB96_RS08910	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DWB96_RS08915	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DWB96_RS08915	COG0072	phenylalanine-tRNA ligase activity
DWB96_RS08920	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DWB96_RS08925	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DWB96_RS08935	COG4509	Sortase family
DWB96_RS08940	COG1120	ATPase activity
DWB96_RS08965	COG4932	domain protein
DWB96_RS08965	COG3583	domain protein
DWB96_RS08965	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DWB96_RS08980	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DWB96_RS09000	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DWB96_RS09005	COG0742	ribosomal rna small subunit methyltransferase
DWB96_RS09015	COG4471	UPF0298 protein
DWB96_RS09020	COG0584	glycerophosphoryl diester phosphodiesterase
DWB96_RS09065	COG3679	Belongs to the UPF0342 family
DWB96_RS09080	COG0109	protoheme IX farnesyltransferase activity
DWB96_RS09085	COG1612	heme a metabolic process
DWB96_RS09095	COG0772	Belongs to the SEDS family
DWB96_RS09100	COG4838	Belongs to the UPF0358 family
DWB96_RS09105	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DWB96_RS09110	COG4896	Protein conserved in bacteria
DWB96_RS09115	COG1217	gtp-binding protein TYPA
DWB96_RS09125	COG0483	inositol monophosphate 1-phosphatase activity
DWB96_RS09130	COG4493	Belongs to the UPF0637 family
DWB96_RS09135	COG1914	H( )-stimulated, divalent metal cation uptake system
DWB96_RS09155	COG1177	transmembrane transport
DWB96_RS09160	COG1176	ABC-type spermidine putrescine transport system, permease component I
DWB96_RS09170	COG3800	Transcriptional regulator
DWB96_RS09170	COG1396	sequence-specific DNA binding
DWB96_RS09175	COG4476	Belongs to the UPF0223 family
DWB96_RS09185	COG0508	dehydrogenase complex catalyzes the overall conversion of
DWB96_RS09190	COG0022	dehydrogenase e1 component
DWB96_RS09195	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DWB96_RS09205	COG0242	peptide deformylase activity
DWB96_RS09210	COG5503	Protein of unknown function (DUF1447)
DWB96_RS09215	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DWB96_RS09220	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DWB96_RS09225	COG0569	domain protein
DWB96_RS09230	COG1294	oxidase, subunit
DWB96_RS09235	COG1271	oxidase subunit
DWB96_RS09250	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DWB96_RS09260	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DWB96_RS09280	COG4172	Belongs to the ABC transporter superfamily
DWB96_RS09285	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DWB96_RS09290	COG0151	Belongs to the GarS family
DWB96_RS09295	COG0138	bifunctional purine biosynthesis protein purh
DWB96_RS09300	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DWB96_RS09305	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DWB96_RS09310	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DWB96_RS09315	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DWB96_RS09320	COG0047	phosphoribosylformylglycinamidine synthase activity
DWB96_RS09325	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DWB96_RS09330	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DWB96_RS09335	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DWB96_RS09340	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DWB96_RS09345	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DWB96_RS09350	COG1017	nitric oxide dioxygenase activity
DWB96_RS09350	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DWB96_RS09360	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DWB96_RS09365	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DWB96_RS09375	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DWB96_RS09390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DWB96_RS09395	COG1316	TRANSCRIPTIONal
DWB96_RS09415	COG1846	Transcriptional regulator
DWB96_RS09420	COG3594	Acyltransferase
DWB96_RS09425	COG0436	Aminotransferase
DWB96_RS09430	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DWB96_RS09440	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DWB96_RS09445	COG1169	isochorismate synthase
DWB96_RS09450	COG1575	Belongs to the MenA family. Type 1 subfamily
DWB96_RS09495	COG4873	Protein conserved in bacteria
DWB96_RS09505	COG0737	Belongs to the 5'-nucleotidase family
DWB96_RS09510	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DWB96_RS09515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DWB96_RS09520	COG0861	Integral membrane protein TerC family
DWB96_RS09525	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DWB96_RS09535	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DWB96_RS09540	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DWB96_RS09545	COG2814	Major facilitator Superfamily
DWB96_RS09550	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DWB96_RS09555	COG2382	esterase
DWB96_RS09560	COG0628	permease
DWB96_RS09570	COG0569	domain protein
DWB96_RS09570	COG0475	glutathione-regulated potassium exporter activity
DWB96_RS09575	COG2239	Acts as a magnesium transporter
DWB96_RS09580	COG0564	pseudouridine synthase activity
DWB96_RS09590	COG2357	RelA SpoT domain protein
DWB96_RS09605	COG2346	COG2346, Truncated hemoglobins
DWB96_RS09610	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DWB96_RS09615	COG1164	Oligoendopeptidase f
DWB96_RS09625	COG4862	establishment of competence for transformation
DWB96_RS09630	COG1393	Belongs to the ArsC family
DWB96_RS09635	COG0180	Tryptophanyl-tRNA synthetase
DWB96_RS09640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DWB96_RS09645	COG0601	transmembrane transport
DWB96_RS09650	COG4608	Belongs to the ABC transporter superfamily
DWB96_RS09655	COG0444	Belongs to the ABC transporter superfamily
DWB96_RS09670	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DWB96_RS09680	COG1881	PFAM PEBP family protein
DWB96_RS09685	COG0542	response to heat
DWB96_RS09700	COG0561	phosphatase activity
DWB96_RS09705	COG0446	pyridine nucleotide-disulphide oxidoreductase
DWB96_RS09715	COG0179	Fumarylacetoacetate (FAA) hydrolase
DWB96_RS09720	COG1074	ATP-dependent DNA helicase activity
DWB96_RS09725	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
DWB96_RS09740	COG0398	Pfam SNARE associated Golgi protein
DWB96_RS09745	COG0166	Belongs to the GPI family
DWB96_RS09750	COG0137	argininosuccinate synthase activity
DWB96_RS09755	COG0165	Argininosuccinate lyase
DWB96_RS09760	COG0584	glycerophosphoryl diester phosphodiesterase
DWB96_RS09775	COG1902	pentaerythritol trinitrate reductase activity
DWB96_RS09780	COG1098	S1 RNA binding domain
DWB96_RS09785	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DWB96_RS09795	COG2111	Na H antiporter
DWB96_RS09795	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DWB96_RS09800	COG2111	Na H antiporter
DWB96_RS09805	COG1006	Multisubunit Na H antiporter MnhC subunit
DWB96_RS09810	COG0651	ATP synthesis coupled electron transport
DWB96_RS09815	COG1863	multisubunit Na H antiporter MnhE subunit
DWB96_RS09820	COG2212	antiporter activity
DWB96_RS09825	COG1320	monovalent cation:proton antiporter activity
DWB96_RS09835	COG2050	protein possibly involved in aromatic compounds catabolism
DWB96_RS09840	COG2056	Na+-H+ antiporter family
DWB96_RS09845	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DWB96_RS09850	COG1252	NADH dehydrogenase
DWB96_RS09855	COG0316	Belongs to the HesB IscA family
DWB96_RS09860	COG4844	belongs to the
DWB96_RS09865	COG1252	NADH dehydrogenase
DWB96_RS09870	COG4837	Protein of unknown function (DUF1462)
DWB96_RS09875	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DWB96_RS09880	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
DWB96_RS09890	COG1696	Membrane protein involved in D-alanine export
DWB96_RS09895	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DWB96_RS09910	COG0647	UMP catabolic process
DWB96_RS09915	COG2445	Protein of unknown function DUF86
DWB96_RS09925	COG4470	Protein conserved in bacteria
DWB96_RS09930	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DWB96_RS09935	COG0737	Belongs to the 5'-nucleotidase family
DWB96_RS09940	COG0730	response to heat
DWB96_RS09945	COG1801	Protein of unknown function DUF72
DWB96_RS09950	COG2070	2-Nitropropane dioxygenase
DWB96_RS09955	COG1253	flavin adenine dinucleotide binding
DWB96_RS10045	COG1388	LysM domain
DWB96_RS10045	COG3942	CHAP domain
DWB96_RS10055	COG0719	Fe-S assembly protein
DWB96_RS10060	COG0822	iron-sulfur transferase activity
DWB96_RS10065	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DWB96_RS10070	COG0719	Fe-S assembly protein
DWB96_RS10075	COG0396	ATPase activity
DWB96_RS10090	COG1464	Belongs to the NlpA lipoprotein family
DWB96_RS10095	COG2011	ABC-type metal ion transport system permease component
DWB96_RS10100	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DWB96_RS10110	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DWB96_RS10115	COG0509	glycine decarboxylation via glycine cleavage system
DWB96_RS10120	COG1393	Belongs to the ArsC family
DWB96_RS10125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DWB96_RS10135	COG0710	3-dehydroquinate dehydratase activity
DWB96_RS10140	COG1764	response to oxidative stress
DWB96_RS10150	COG1279	arginine transmembrane transporter activity
DWB96_RS10155	COG0406	alpha-ribazole phosphatase activity
DWB96_RS10190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DWB96_RS10195	COG4195	phage-related replication protein
DWB96_RS10220	COG1278	Cold shock
DWB96_RS10270	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DWB96_RS10275	COG0557	exoribonuclease II activity
DWB96_RS10280	COG1647	Serine aminopeptidase, S33
DWB96_RS10285	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DWB96_RS10295	COG0148	phosphopyruvate hydratase activity
DWB96_RS10300	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DWB96_RS10305	COG0149	triose-phosphate isomerase activity
DWB96_RS10310	COG0126	phosphoglycerate kinase activity
DWB96_RS10315	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DWB96_RS10335	COG1090	epimerase
DWB96_RS10345	COG0740	serine-type endopeptidase activity
DWB96_RS10355	COG1481	regulation of sporulation
DWB96_RS10360	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DWB96_RS10365	COG1660	Displays ATPase and GTPase activities
DWB96_RS10370	COG0492	ferredoxin-NADP+ reductase activity
DWB96_RS10385	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DWB96_RS10390	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DWB96_RS10395	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DWB96_RS10400	COG0556	nucleotide-excision repair
DWB96_RS10415	COG3942	CHAP domain
DWB96_RS10415	COG1388	LysM domain
DWB96_RS10425	COG0653	protein targeting
DWB96_RS10435	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DWB96_RS10440	COG1040	competence protein
DWB96_RS10445	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
DWB96_RS10455	COG1739	Uncharacterized protein family UPF0029
DWB96_RS10460	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DWB96_RS10465	COG2199	diguanylate cyclase activity
DWB96_RS10480	COG2195	Cleaves the N-terminal amino acid of tripeptides
DWB96_RS10485	COG1929	Belongs to the glycerate kinase type-1 family
DWB96_RS10505	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DWB96_RS10520	COG4604	ABC transporter, ATP-binding protein
DWB96_RS10525	COG4605	iron ion homeostasis
DWB96_RS10530	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWB96_RS10540	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DWB96_RS10545	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DWB96_RS10550	COG1780	Probably involved in ribonucleotide reductase function
DWB96_RS10560	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DWB96_RS10565	COG3104	oligopeptide transport
DWB96_RS10570	COG1597	lipid kinase activity
DWB96_RS10580	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DWB96_RS10585	COG1174	glycine betaine transport
DWB96_RS10595	COG0514	ATP-dependent DNA helicase (RecQ)
DWB96_RS10600	COG0488	(ABC) transporter
DWB96_RS10610	COG1368	sulfuric ester hydrolase activity
DWB96_RS10635	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DWB96_RS10645	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DWB96_RS10650	COG0720	synthase
DWB96_RS10655	COG0602	queuosine metabolic process
DWB96_RS10675	COG0745	RESPONSE REGULATOR receiver
DWB96_RS10680	COG5002	protein histidine kinase activity
DWB96_RS10685	COG0463	Glycosyl transferase, family 2
DWB96_RS10690	COG0656	L-ascorbic acid biosynthetic process
DWB96_RS10695	COG1253	flavin adenine dinucleotide binding
DWB96_RS10700	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DWB96_RS10705	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DWB96_RS10705	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DWB96_RS10705	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DWB96_RS10710	COG1105	Belongs to the carbohydrate kinase PfkB family
DWB96_RS10715	COG1349	DNA-binding transcription factor activity
DWB96_RS10720	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DWB96_RS10750	COG0415	Belongs to the DNA photolyase family
DWB96_RS10755	COG0471	metal ion transport
DWB96_RS10760	COG0039	L-malate dehydrogenase activity
DWB96_RS10770	COG0523	cobalamin synthesis protein
DWB96_RS10780	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DWB96_RS10785	COG4988	ABC transporter
DWB96_RS10790	COG1968	undecaprenyl-diphosphatase activity
DWB96_RS10800	COG1671	Belongs to the UPF0178 family
DWB96_RS10805	COG1611	Belongs to the LOG family
DWB96_RS10810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DWB96_RS10835	COG2839	Protein conserved in bacteria
DWB96_RS10840	COG2814	Major facilitator Superfamily
DWB96_RS10845	COG0583	DNA-binding transcription factor activity
DWB96_RS10860	COG0217	transcriptional regulatory protein
DWB96_RS10870	COG4977	sequence-specific DNA binding
DWB96_RS10870	COG1917	Cupin 2, conserved barrel domain protein
DWB96_RS10880	COG1388	LysM domain
DWB96_RS10880	COG3942	CHAP domain
DWB96_RS10885	COG0306	phosphate transporter
DWB96_RS10890	COG1392	Phosphate transport regulator
DWB96_RS10895	COG0577	efflux transmembrane transporter activity
DWB96_RS10900	COG1136	(ABC) transporter
DWB96_RS10905	COG2205	protein histidine kinase activity
DWB96_RS10910	COG0745	RESPONSE REGULATOR receiver
DWB96_RS10915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DWB96_RS10925	COG0657	acetylesterase activity
DWB96_RS10930	COG3949	Membrane
DWB96_RS10940	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
DWB96_RS10945	COG1461	Dihydroxyacetone kinase
DWB96_RS10950	COG2376	Dihydroxyacetone kinase
DWB96_RS10955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWB96_RS10960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWB96_RS10965	COG1120	ATPase activity
DWB96_RS10970	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DWB96_RS10980	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DWB96_RS10985	COG1132	(ABC) transporter
DWB96_RS10990	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DWB96_RS11000	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DWB96_RS11005	COG1682	transport, permease protein
DWB96_RS11010	COG1134	teichoic acid transport
DWB96_RS11015	COG5609	conserved protein (DUF2294)
DWB96_RS11025	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
DWB96_RS11035	COG1321	iron dependent repressor
DWB96_RS11040	COG1121	(ABC) transporter
DWB96_RS11045	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DWB96_RS11050	COG0803	Belongs to the bacterial solute-binding protein 9 family
DWB96_RS11060	COG1320	monovalent cation:proton antiporter activity
DWB96_RS11065	COG2212	antiporter activity
DWB96_RS11070	COG1863	multisubunit Na H antiporter MnhE subunit
DWB96_RS11075	COG0651	ATP synthesis coupled electron transport
DWB96_RS11080	COG1006	Multisubunit Na H antiporter MnhC subunit
DWB96_RS11085	COG2111	Na H antiporter
DWB96_RS11090	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DWB96_RS11090	COG2111	Na H antiporter
DWB96_RS11095	COG0582	viral genome integration into host DNA
DWB96_RS11125	COG0596	Alpha beta hydrolase
DWB96_RS11140	COG2267	carboxylic ester hydrolase activity
DWB96_RS11145	COG0546	phosphoglycolate phosphatase activity
DWB96_RS11150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWB96_RS11155	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DWB96_RS11170	COG0789	Transcriptional regulator
DWB96_RS11175	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DWB96_RS11180	COG0018	arginyl-trna synthetase
DWB96_RS11200	COG3875	lactate racemase activity
DWB96_RS11205	COG1606	tRNA processing
DWB96_RS11210	COG1691	(AIR) carboxylase
DWB96_RS11215	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
DWB96_RS11230	COG1078	dGTPase activity
DWB96_RS11240	COG0655	NAD(P)H dehydrogenase (quinone) activity
DWB96_RS11250	COG0667	Aldo Keto reductase
DWB96_RS11290	COG0860	N-Acetylmuramoyl-L-alanine amidase
DWB96_RS11290	COG1388	LysM domain
DWB96_RS11415	COG1783	phage Terminase large subunit
DWB96_RS11420	COG3728	DNA packaging
DWB96_RS11420	COG5484	DNA packaging
DWB96_RS11435	COG0756	dUTP diphosphatase activity
DWB96_RS11530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DWB96_RS11535	COG4844	belongs to the
DWB96_RS11555	COG0095	Lipoate-protein ligase
DWB96_RS11560	COG0280	phosphate acetyltransferase
DWB96_RS11565	COG3253	May function as heme-dependent peroxidase
DWB96_RS11585	COG2363	Small membrane protein
DWB96_RS11595	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DWB96_RS11600	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
DWB96_RS11605	COG0351	phosphomethylpyrimidine kinase
DWB96_RS11610	COG0477	Major facilitator Superfamily
DWB96_RS11625	COG0183	Belongs to the thiolase family
DWB96_RS11630	COG0318	PFAM AMP-dependent synthetase and ligase
DWB96_RS11645	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
DWB96_RS11650	COG0363	glucosamine-6-phosphate deaminase activity
DWB96_RS11660	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DWB96_RS11670	COG2271	Major facilitator Superfamily
DWB96_RS11680	COG0431	NADPH-dependent FMN reductase
DWB96_RS11685	COG0561	phosphatase activity
DWB96_RS11695	COG1428	Deoxynucleoside kinase
DWB96_RS11700	COG1428	Deoxynucleoside kinase
DWB96_RS11705	COG1028	Short-chain dehydrogenase reductase Sdr
DWB96_RS11710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWB96_RS11715	COG0546	phosphoglycolate phosphatase activity
DWB96_RS11720	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DWB96_RS11730	COG0737	Belongs to the 5'-nucleotidase family
DWB96_RS11735	COG1069	ribulokinase activity
DWB96_RS11740	COG1063	alcohol dehydrogenase
DWB96_RS11745	COG2814	Major facilitator Superfamily
DWB96_RS11750	COG1349	DNA-binding transcription factor activity
DWB96_RS11780	COG1473	amidohydrolase
DWB96_RS11785	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DWB96_RS11790	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DWB96_RS11800	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DWB96_RS11810	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DWB96_RS11815	COG0085	RNA polymerase activity
DWB96_RS11820	COG2813	Specifically methylates the guanine in position
DWB96_RS11825	COG0222	ribosome binding
DWB96_RS11830	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DWB96_RS11840	COG0081	regulation of translation
DWB96_RS11845	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DWB96_RS11850	COG0250	Participates in transcription elongation, termination and antitermination
DWB96_RS11855	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DWB96_RS11860	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DWB96_RS11870	COG3688	RNA-binding protein containing a PIN domain
DWB96_RS11875	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DWB96_RS11880	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
DWB96_RS11885	COG0215	cysteine-tRNA ligase activity
DWB96_RS11890	COG1045	serine acetyltransferase
DWB96_RS11895	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DWB96_RS11900	COG4956	integral membrane protein (PIN domain superfamily)
DWB96_RS11905	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DWB96_RS11910	COG0542	response to heat
DWB96_RS11915	COG3869	Catalyzes the specific phosphorylation of arginine residues in
DWB96_RS11920	COG3880	PFAM UvrB UvrC protein
DWB96_RS11930	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DWB96_RS11935	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DWB96_RS11940	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DWB96_RS11945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DWB96_RS12030	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DWB96_RS12035	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DWB96_RS12040	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DWB96_RS12045	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DWB96_RS12055	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DWB96_RS12060	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DWB96_RS12065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DWB96_RS12075	COG0037	tRNA processing
DWB96_RS12080	COG1098	S1 RNA binding domain
DWB96_RS12090	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DWB96_RS12095	COG3956	TIGRFAM MazG family protein
DWB96_RS12100	COG2244	polysaccharide biosynthetic process
DWB96_RS12105	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DWB96_RS12110	COG0193	aminoacyl-tRNA hydrolase activity
DWB96_RS12115	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DWB96_RS12120	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DWB96_RS12125	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DWB96_RS12130	COG2088	sporulation resulting in formation of a cellular spore
DWB96_RS12135	COG0251	oxidation-reduction process
DWB96_RS12140	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DWB96_RS12145	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DWB96_RS12150	COG4466	Protein conserved in bacteria
DWB96_RS12155	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DWB96_RS12160	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DWB96_RS12165	COG0084	hydrolase, TatD family'
DWB96_RS12170	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DWB96_RS12170	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DWB96_RS12175	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DWB96_RS12180	COG2827	Endonuclease containing a URI domain
DWB96_RS12185	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DWB96_RS12190	COG4467	Involved in initiation control of chromosome replication
DWB96_RS12195	COG1774	PSP1 C-terminal conserved region
DWB96_RS12200	COG0470	DNA polymerase III
DWB96_RS12205	COG3870	Protein conserved in bacteria
DWB96_RS12210	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DWB96_RS12215	COG1982	Orn Lys Arg decarboxylase major
DWB96_RS12240	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DWB96_RS12245	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DWB96_RS12250	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DWB96_RS12265	COG2188	Transcriptional regulator
DWB96_RS12270	COG0366	Alpha amylase catalytic
DWB96_RS12275	COG1263	PTS System
DWB96_RS12275	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DWB96_RS12285	COG0493	'glutamate synthase
DWB96_RS12290	COG0069	glutamate synthase activity
DWB96_RS12290	COG0070	glutamate synthase
DWB96_RS12290	COG0067	glutamate synthase
DWB96_RS12295	COG0583	DNA-binding transcription factor activity
DWB96_RS12310	COG0456	acetyltransferase
DWB96_RS12325	COG0438	transferase activity, transferring glycosyl groups
DWB96_RS12330	COG1388	LysM domain
DWB96_RS12330	COG3942	CHAP domain
DWB96_RS12340	COG2011	ABC-type metal ion transport system permease component
DWB96_RS12345	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DWB96_RS12350	COG0626	cystathionine gamma-synthase activity
DWB96_RS12355	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DWB96_RS12370	COG0733	neurotransmitter:sodium symporter activity
DWB96_RS12380	COG1647	Serine aminopeptidase, S33
DWB96_RS12400	COG5609	conserved protein (DUF2294)
DWB96_RS12405	COG3002	Belongs to the UPF0753 family
DWB96_RS12410	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DWB96_RS12430	COG2814	Major facilitator Superfamily
DWB96_RS12435	COG0523	cobalamin synthesis protein
DWB96_RS12445	COG2211	Major facilitator Superfamily
DWB96_RS12470	COG0519	Catalyzes the synthesis of GMP from XMP
DWB96_RS12470	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DWB96_RS12475	COG0516	GMP reductase activity
DWB96_RS12475	COG0517	IMP dehydrogenase activity
DWB96_RS12480	COG2233	PERMEase
DWB96_RS12485	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DWB96_RS12500	COG5183	chlorophyll binding
DWB96_RS12505	COG1823	symporter activity
DWB96_RS12510	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DWB96_RS12515	COG0778	Nitroreductase
DWB96_RS12525	COG0450	alkyl hydroperoxide reductase
DWB96_RS12530	COG3634	alkyl hydroperoxide reductase activity
DWB96_RS12550	COG1280	lysine exporter protein (LysE YggA)
DWB96_RS12640	COG3728	DNA packaging
DWB96_RS12640	COG5484	DNA packaging
DWB96_RS12730	COG0582	viral genome integration into host DNA
DWB96_RS12735	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DWB96_RS12745	COG0360	Binds together with S18 to 16S ribosomal RNA
DWB96_RS12760	COG0012	GTP binding
DWB96_RS12765	COG4481	Protein conserved in bacteria
DWB96_RS12770	COG0668	transmembrane transport
DWB96_RS12775	COG1475	DNA binding
DWB96_RS12785	COG0626	cystathionine gamma-synthase activity
DWB96_RS12790	COG0626	cystathionine gamma-synthase activity
DWB96_RS12795	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DWB96_RS12795	COG0646	methionine synthase
DWB96_RS12800	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DWB96_RS12810	COG0183	Belongs to the thiolase family
DWB96_RS12825	COG1476	TRANSCRIPTIONal
DWB96_RS12835	COG1131	(ABC) transporter
DWB96_RS12845	COG2814	Major facilitator Superfamily
DWB96_RS12890	COG1136	(ABC) transporter
DWB96_RS12895	COG0577	efflux transmembrane transporter activity
DWB96_RS12920	COG0577	efflux transmembrane transporter activity
DWB96_RS12925	COG1136	(ABC) transporter
DWB96_RS12930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DWB96_RS12980	COG1475	DNA binding
DWB96_RS12985	COG0357	Ribosomal RNA small subunit methyltransferase G
DWB96_RS12990	COG0445	tRNA wobble uridine modification
DWB96_RS12995	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DWB96_RS13000	COG0594	ribonuclease P activity
DWB96_RS13030	COG0579	oxidoreductase
DWB96_RS13035	COG1733	regulation of RNA biosynthetic process
DWB96_RS13040	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
DWB96_RS13045	COG0693	protein deglycase activity
DWB96_RS13100	COG3682	Transcriptional regulator
DWB96_RS13195	COG5658	integral membrane protein