locus-tag	class	description
HHJ99_RS00010	COG5146	pantothenate kinase activity
HHJ99_RS00015	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HHJ99_RS00020	COG3343	RNA polymerase activity
HHJ99_RS00025	COG0504	CTP synthase activity
HHJ99_RS00040	COG0191	fructose-bisphosphate aldolase activity
HHJ99_RS00045	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HHJ99_RS00055	COG1012	belongs to the aldehyde dehydrogenase family
HHJ99_RS00060	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HHJ99_RS00065	COG0254	rRNA binding
HHJ99_RS00070	COG1435	thymidine kinase activity
HHJ99_RS00080	COG2890	protein-(glutamine-N5) methyltransferase activity
HHJ99_RS00085	COG0009	L-threonylcarbamoyladenylate synthase
HHJ99_RS00090	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HHJ99_RS00095	COG4475	Protein of unknown function (DUF436)
HHJ99_RS00100	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HHJ99_RS00105	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HHJ99_RS00110	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HHJ99_RS00120	COG0356	it plays a direct role in the translocation of protons across the membrane
HHJ99_RS00130	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HHJ99_RS00135	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HHJ99_RS00140	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HHJ99_RS00145	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HHJ99_RS00150	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HHJ99_RS00155	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HHJ99_RS00170	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HHJ99_RS00180	COG0629	single-stranded DNA binding
HHJ99_RS00185	COG1388	LysM domain
HHJ99_RS00190	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HHJ99_RS00200	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HHJ99_RS00205	COG0352	thiamine-phosphate diphosphorylase activity
HHJ99_RS00210	COG0706	membrane insertase activity
HHJ99_RS00215	COG1418	mRNA catabolic process
HHJ99_RS00220	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HHJ99_RS00225	COG1937	Protein conserved in bacteria
HHJ99_RS00240	COG0772	Belongs to the SEDS family
HHJ99_RS00245	COG1181	Belongs to the D-alanine--D-alanine ligase family
HHJ99_RS00250	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HHJ99_RS00255	COG0513	Belongs to the DEAD box helicase family
HHJ99_RS00270	COG3402	PFAM membrane-flanked domain
HHJ99_RS00275	COG0736	holo-[acyl-carrier-protein] synthase activity
HHJ99_RS00280	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HHJ99_RS00290	COG2337	Toxic component of a toxin-antitoxin (TA) module
HHJ99_RS00295	COG2208	phosphoserine phosphatase activity
HHJ99_RS00310	COG1191	sigma factor activity
HHJ99_RS00315	COG2183	response to ionizing radiation
HHJ99_RS00320	COG3091	SprT-like family
HHJ99_RS00360	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HHJ99_RS00365	COG0473	3-isopropylmalate dehydrogenase activity
HHJ99_RS00370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HHJ99_RS00375	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HHJ99_RS00385	COG0028	Belongs to the TPP enzyme family
HHJ99_RS00390	COG0129	dihydroxy-acid dehydratase activity
HHJ99_RS00395	COG0802	atpase or kinase
HHJ99_RS00400	COG1214	PFAM Peptidase M22, glycoprotease
HHJ99_RS00405	COG0456	acetyltransferase
HHJ99_RS00410	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HHJ99_RS00415	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HHJ99_RS00420	COG0488	(ABC) transporter
HHJ99_RS00425	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HHJ99_RS00435	COG2391	methyltransferase activity
HHJ99_RS00440	COG0425	Belongs to the sulfur carrier protein TusA family
HHJ99_RS00445	COG0004	ammonium transporteR
HHJ99_RS00450	COG1621	beta-fructofuranosidase activity
HHJ99_RS00455	COG3279	Response regulator of the LytR AlgR family
HHJ99_RS00500	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HHJ99_RS00505	COG0459	protein refolding
HHJ99_RS00510	COG0582	viral genome integration into host DNA
HHJ99_RS00595	COG5484	DNA packaging
HHJ99_RS00595	COG3728	DNA packaging
HHJ99_RS00660	COG1725	Transcriptional regulator
HHJ99_RS00675	COG1131	(ABC) transporter
HHJ99_RS00720	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HHJ99_RS00725	COG2706	6-phosphogluconolactonase activity
HHJ99_RS00730	COG1012	belongs to the aldehyde dehydrogenase family
HHJ99_RS00735	COG1227	inorganic diphosphatase activity
HHJ99_RS00740	COG1335	isochorismatase
HHJ99_RS00750	COG0077	Prephenate dehydratase
HHJ99_RS00760	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HHJ99_RS00765	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HHJ99_RS00770	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HHJ99_RS00785	COG4496	protein, YerC YecD
HHJ99_RS00790	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HHJ99_RS00795	COG0210	DNA helicase
HHJ99_RS00800	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HHJ99_RS00810	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HHJ99_RS00815	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HHJ99_RS00820	COG0154	amidase activity
HHJ99_RS00825	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HHJ99_RS00830	COG1597	lipid kinase activity
HHJ99_RS00835	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HHJ99_RS00855	COG1528	Iron-storage protein
HHJ99_RS00875	COG4129	membrane
HHJ99_RS00880	COG0024	Methionine aminopeptidase
HHJ99_RS00900	COG2197	response regulator
HHJ99_RS00905	COG1295	ribonuclease BN
HHJ99_RS00915	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HHJ99_RS00920	COG4840	Belongs to the UPF0435 family
HHJ99_RS00925	COG2309	aminopeptidase activity
HHJ99_RS00930	COG1607	acyl-coa hydrolase
HHJ99_RS00935	COG0535	radical SAM domain protein
HHJ99_RS00945	COG0693	protein deglycase activity
HHJ99_RS00950	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HHJ99_RS00955	COG2137	regulation of response to DNA damage stimulus
HHJ99_RS00965	COG1134	teichoic acid transport
HHJ99_RS00965	COG1388	LysM domain
HHJ99_RS00975	COG1988	membrane-bound metal-dependent
HHJ99_RS00985	COG3557	Belongs to the UPF0374 family
HHJ99_RS00995	COG4129	membrane
HHJ99_RS01000	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HHJ99_RS01005	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HHJ99_RS01010	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HHJ99_RS01015	COG0735	belongs to the Fur family
HHJ99_RS01195	COG0765	amino acid transport
HHJ99_RS01200	COG1126	abc transporter atp-binding protein
HHJ99_RS01205	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HHJ99_RS01215	COG0363	glucosamine-6-phosphate deaminase activity
HHJ99_RS01230	COG0114	fumarate hydratase activity
HHJ99_RS01235	COG0564	pseudouridine synthase activity
HHJ99_RS01240	COG4585	Histidine kinase
HHJ99_RS01240	COG2203	Gaf domain
HHJ99_RS01245	COG2197	response regulator
HHJ99_RS01255	COG4399	Belongs to the UPF0754 family
HHJ99_RS01260	COG3679	Belongs to the UPF0342 family
HHJ99_RS01265	COG0420	3'-5' exonuclease activity
HHJ99_RS01275	COG3481	metal-dependent phosphohydrolase, HD sub domain
HHJ99_RS01285	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HHJ99_RS01300	COG0537	adenosine 5'-monophosphoramidase activity
HHJ99_RS01305	COG1131	(ABC) transporter
HHJ99_RS01310	COG4473	ABC transporter
HHJ99_RS01315	COG2329	Antibiotic biosynthesis monooxygenase
HHJ99_RS01320	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HHJ99_RS01335	COG3545	Serine hydrolase
HHJ99_RS01380	COG0318	PFAM AMP-dependent synthetase and ligase
HHJ99_RS01395	COG0494	nUDIX hydrolase
HHJ99_RS01400	COG1506	peptidase
HHJ99_RS01410	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HHJ99_RS01420	COG0656	L-ascorbic acid biosynthetic process
HHJ99_RS01425	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HHJ99_RS01430	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HHJ99_RS01440	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HHJ99_RS01465	COG5632	N-Acetylmuramoyl-L-alanine amidase
HHJ99_RS01465	COG4193	domain, Protein
HHJ99_RS01465	COG3266	domain, Protein
HHJ99_RS01475	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HHJ99_RS01475	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HHJ99_RS01485	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HHJ99_RS01485	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HHJ99_RS01490	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HHJ99_RS01495	COG0506	proline dehydrogenase activity
HHJ99_RS01500	COG2267	carboxylic ester hydrolase activity
HHJ99_RS01510	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HHJ99_RS01515	COG1242	4 iron, 4 sulfur cluster binding
HHJ99_RS01520	COG2814	Major facilitator Superfamily
HHJ99_RS01525	COG0495	leucyl-tRNA aminoacylation
HHJ99_RS01540	COG2081	HI0933 family
HHJ99_RS01545	COG2244	polysaccharide biosynthetic process
HHJ99_RS01550	COG1187	pseudouridine synthase activity
HHJ99_RS01560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HHJ99_RS01565	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HHJ99_RS01570	COG0510	thiamine kinase activity
HHJ99_RS01575	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HHJ99_RS01580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HHJ99_RS01590	COG1363	Peptidase, m42
HHJ99_RS01595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HHJ99_RS01600	COG4848	Belongs to the UPF0354 family
HHJ99_RS01605	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HHJ99_RS01610	COG1674	ftsk spoiiie
HHJ99_RS01615	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HHJ99_RS01620	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HHJ99_RS01630	COG1605	Chorismate mutase
HHJ99_RS01630	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HHJ99_RS01635	COG1609	Transcriptional regulator
HHJ99_RS01645	COG0454	-acetyltransferase
HHJ99_RS01650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HHJ99_RS01655	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HHJ99_RS01665	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HHJ99_RS01675	COG0477	Major facilitator Superfamily
HHJ99_RS01680	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HHJ99_RS01685	COG0204	Acyl-transferase
HHJ99_RS01690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HHJ99_RS01690	COG1263	PTS System
HHJ99_RS01700	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HHJ99_RS01710	COG1764	response to oxidative stress
HHJ99_RS01715	COG0584	glycerophosphoryl diester phosphodiesterase
HHJ99_RS01720	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HHJ99_RS01725	COG1956	GAF domain-containing protein
HHJ99_RS01730	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HHJ99_RS01735	COG1104	cysteine desulfurase activity
HHJ99_RS01740	COG0301	tRNA thio-modification
HHJ99_RS01750	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HHJ99_RS01755	COG0827	DNA restriction-modification system
HHJ99_RS01760	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HHJ99_RS01765	COG0589	response to stress
HHJ99_RS01775	COG0006	proline dipeptidase activity
HHJ99_RS01780	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HHJ99_RS01790	COG4109	DRTGG domain
HHJ99_RS01795	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HHJ99_RS01800	COG0587	DNA-directed DNA polymerase activity
HHJ99_RS01805	COG0281	malic enzyme
HHJ99_RS01810	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HHJ99_RS01820	COG0205	6-phosphofructokinase activity
HHJ99_RS01825	COG0469	pyruvate kinase activity
HHJ99_RS01830	COG1113	amino acid transport
HHJ99_RS01835	COG0372	Belongs to the citrate synthase family
HHJ99_RS01840	COG0538	isocitrate dehydrogenase activity
HHJ99_RS01845	COG0745	RESPONSE REGULATOR receiver
HHJ99_RS01850	COG5002	protein histidine kinase activity
HHJ99_RS01855	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HHJ99_RS01855	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HHJ99_RS01860	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HHJ99_RS01865	COG0237	dephospho-CoA kinase activity
HHJ99_RS01870	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HHJ99_RS01875	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HHJ99_RS01880	COG3611	Membrane attachment protein
HHJ99_RS01885	COG1484	DNA-dependent DNA replication
HHJ99_RS01890	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HHJ99_RS01895	COG0833	amino acid
HHJ99_RS01900	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HHJ99_RS01905	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HHJ99_RS01910	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HHJ99_RS01915	COG4112	unkown
HHJ99_RS01925	COG0544	peptidyl-prolyl cis-trans isomerase activity
HHJ99_RS01930	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HHJ99_RS01935	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HHJ99_RS01940	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HHJ99_RS01945	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HHJ99_RS01950	COG0181	hydroxymethylbilane synthase activity
HHJ99_RS01960	COG0113	porphobilinogen synthase activity
HHJ99_RS01965	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HHJ99_RS01975	COG2818	Glycosylase
HHJ99_RS01980	COG0525	valine-tRNA ligase activity
HHJ99_RS01985	COG0285	dihydrofolate synthase activity
HHJ99_RS01995	COG2003	Belongs to the UPF0758 family
HHJ99_RS02025	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HHJ99_RS02030	COG2868	ribosomal protein
HHJ99_RS02035	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HHJ99_RS02040	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HHJ99_RS02045	COG4492	Belongs to the UPF0735 family
HHJ99_RS02050	COG0632	four-way junction helicase activity
HHJ99_RS02055	COG2255	four-way junction helicase activity
HHJ99_RS02065	COG0343	queuine tRNA-ribosyltransferase activity
HHJ99_RS02070	COG1862	Preprotein translocase
HHJ99_RS02075	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HHJ99_RS02075	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HHJ99_RS02080	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HHJ99_RS02080	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HHJ99_RS02090	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HHJ99_RS02095	COG1490	D-aminoacyl-tRNA deacylase activity
HHJ99_RS02100	COG0860	N-Acetylmuramoyl-L-alanine amidase
HHJ99_RS02110	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HHJ99_RS02120	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HHJ99_RS02125	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HHJ99_RS02130	COG1959	2 iron, 2 sulfur cluster binding
HHJ99_RS02145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HHJ99_RS02150	COG1104	cysteine desulfurase activity
HHJ99_RS02155	COG0482	sulfurtransferase activity
HHJ99_RS02165	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HHJ99_RS02170	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HHJ99_RS02175	COG4472	Bacterial protein of unknown function (DUF965)
HHJ99_RS02180	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HHJ99_RS02185	COG3906	Belongs to the UPF0473 family
HHJ99_RS02205	COG0572	uridine kinase
HHJ99_RS02210	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HHJ99_RS02215	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HHJ99_RS02220	COG1984	allophanate hydrolase subunit 2
HHJ99_RS02225	COG0511	ligase activity, forming carbon-carbon bonds
HHJ99_RS02230	COG0439	Biotin carboxylase
HHJ99_RS02235	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HHJ99_RS02240	COG1914	H( )-stimulated, divalent metal cation uptake system
HHJ99_RS02245	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HHJ99_RS02250	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HHJ99_RS02255	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HHJ99_RS02265	COG1534	Rna-binding protein
HHJ99_RS02270	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HHJ99_RS02275	COG1713	HD superfamily hydrolase involved in NAD metabolism
HHJ99_RS02280	COG0799	negative regulation of ribosome biogenesis
HHJ99_RS02285	COG4106	trans-aconitate 2-methyltransferase activity
HHJ99_RS02290	COG1555	photosystem II stabilization
HHJ99_RS02290	COG1596	polysaccharide export
HHJ99_RS02295	COG2131	deaminase
HHJ99_RS02305	COG2333	competence protein COMEC
HHJ99_RS02305	COG0658	competence protein
HHJ99_RS02310	COG1466	dna polymerase III delta subunit
HHJ99_RS02315	COG0268	Binds directly to 16S ribosomal RNA
HHJ99_RS02320	COG0481	GTPase activity
HHJ99_RS02325	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HHJ99_RS02330	COG1420	regulation of RNA biosynthetic process
HHJ99_RS02335	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HHJ99_RS02340	COG0443	Heat shock 70 kDa protein
HHJ99_RS02345	COG0484	heat shock protein binding
HHJ99_RS02350	COG2264	protein methyltransferase activity
HHJ99_RS02355	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HHJ99_RS02360	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HHJ99_RS02370	COG1030	water channel activity
HHJ99_RS02375	COG4864	UPF0365 protein
HHJ99_RS02385	COG1702	phosphate starvation-inducible protein PhoH
HHJ99_RS02390	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HHJ99_RS02405	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HHJ99_RS02410	COG1381	Involved in DNA repair and RecF pathway recombination
HHJ99_RS02415	COG0423	glycine-tRNA ligase activity
HHJ99_RS02420	COG0517	IMP dehydrogenase activity
HHJ99_RS02425	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HHJ99_RS02430	COG0358	DNA primase activity
HHJ99_RS02435	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HHJ99_RS02440	COG2384	SAM-dependent methyltransferase
HHJ99_RS02445	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HHJ99_RS02450	COG0513	Belongs to the DEAD box helicase family
HHJ99_RS02455	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HHJ99_RS02460	COG1121	(ABC) transporter
HHJ99_RS02465	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HHJ99_RS02485	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HHJ99_RS02490	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HHJ99_RS02495	COG0457	Tetratricopeptide repeat
HHJ99_RS02495	COG0705	Rhomboid family
HHJ99_RS02500	COG4483	Protein conserved in bacteria
HHJ99_RS02505	COG1940	carbohydrate kinase activity
HHJ99_RS02510	COG0011	TIGRFAM Protein of
HHJ99_RS02515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HHJ99_RS02520	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HHJ99_RS02525	COG1459	type II secretion system
HHJ99_RS02530	COG4537	Required for transformation and DNA binding
HHJ99_RS02550	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HHJ99_RS02555	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HHJ99_RS02560	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HHJ99_RS02565	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HHJ99_RS02570	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HHJ99_RS02575	COG0095	Lipoate-protein ligase
HHJ99_RS02590	COG0006	proline dipeptidase activity
HHJ99_RS02595	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HHJ99_RS02600	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HHJ99_RS02605	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HHJ99_RS02610	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HHJ99_RS02615	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HHJ99_RS02620	COG0511	ligase activity, forming carbon-carbon bonds
HHJ99_RS02625	COG0439	Biotin carboxylase
HHJ99_RS02630	COG1302	Protein conserved in bacteria
HHJ99_RS02635	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HHJ99_RS02640	COG1570	exodeoxyribonuclease VII activity
HHJ99_RS02650	COG0142	geranyltranstransferase activity
HHJ99_RS02655	COG1438	arginine binding
HHJ99_RS02660	COG0497	DNA recombination
HHJ99_RS02665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HHJ99_RS02670	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HHJ99_RS02675	COG0022	dehydrogenase e1 component
HHJ99_RS02680	COG0508	dehydrogenase complex catalyzes the overall conversion of
HHJ99_RS02690	COG4129	membrane
HHJ99_RS02700	COG2195	Cleaves the N-terminal amino acid of tripeptides
HHJ99_RS02705	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HHJ99_RS02715	COG0366	Alpha amylase catalytic
HHJ99_RS02725	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HHJ99_RS02730	COG1234	tRNA 3'-trailer cleavage
HHJ99_RS02735	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HHJ99_RS02740	COG0300	oxidoreductase activity
HHJ99_RS02745	COG0667	Aldo Keto reductase
HHJ99_RS02750	COG0494	nUDIX hydrolase
HHJ99_RS02755	COG0735	belongs to the Fur family
HHJ99_RS02760	COG4974	Belongs to the 'phage' integrase family
HHJ99_RS02770	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HHJ99_RS02775	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HHJ99_RS02780	COG1187	pseudouridine synthase activity
HHJ99_RS02785	COG0745	RESPONSE REGULATOR receiver
HHJ99_RS02800	COG1141	Ferredoxin
HHJ99_RS02810	COG0514	ATP-dependent DNA helicase (RecQ)
HHJ99_RS02815	COG1388	LysM domain
HHJ99_RS02815	COG1388	LysM domain
HHJ99_RS02820	COG0492	ferredoxin-NADP+ reductase activity
HHJ99_RS02825	COG0252	asparaginase activity
HHJ99_RS02830	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HHJ99_RS02835	COG0539	negative regulation of cytoplasmic translation
HHJ99_RS02840	COG1160	GTP binding
HHJ99_RS02845	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HHJ99_RS02860	COG2226	methyltransferase
HHJ99_RS02870	COG0105	UTP biosynthetic process
HHJ99_RS02875	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HHJ99_RS02880	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HHJ99_RS02885	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HHJ99_RS02895	COG5582	Belongs to the UPF0302 family
HHJ99_RS02905	COG2738	Putative neutral zinc metallopeptidase
HHJ99_RS02910	COG1694	Mazg nucleotide pyrophosphohydrolase
HHJ99_RS02915	COG0438	transferase activity, transferring glycosyl groups
HHJ99_RS02920	COG0617	tRNA 3'-terminal CCA addition
HHJ99_RS02925	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HHJ99_RS02925	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HHJ99_RS02930	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HHJ99_RS02930	COG1199	ATP-dependent helicase activity
HHJ99_RS02935	COG0017	Asparaginyl-tRNA synthetase
HHJ99_RS02940	COG3935	DnaD domain protein
HHJ99_RS02945	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HHJ99_RS02955	COG4499	WXG100 protein secretion system (Wss), protein YukC
HHJ99_RS02955	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HHJ99_RS02960	COG3331	DNA recombination
HHJ99_RS02970	COG4474	Belongs to the UPF0398 family
HHJ99_RS02975	COG3599	regulation of cell shape
HHJ99_RS02985	COG0116	Belongs to the methyltransferase superfamily
HHJ99_RS02995	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HHJ99_RS03000	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HHJ99_RS03005	COG4372	Transposase
HHJ99_RS03005	COG1196	nuclear chromosome segregation
HHJ99_RS03005	COG1511	domain protein
HHJ99_RS03015	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HHJ99_RS03025	COG1413	lyase activity
HHJ99_RS03030	COG1413	lyase activity
HHJ99_RS03060	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HHJ99_RS03065	COG2190	(PTS) system
HHJ99_RS03070	COG4479	Belongs to the UPF0346 family
HHJ99_RS03075	COG0793	Belongs to the peptidase S41A family
HHJ99_RS03085	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HHJ99_RS03090	COG0671	phosphoesterase, PA-phosphatase related
HHJ99_RS03095	COG3842	ATPase activity
HHJ99_RS03100	COG4209	transmembrane transport
HHJ99_RS03110	COG0395	ABC-type sugar transport system, permease component
HHJ99_RS03120	COG0534	Mate efflux family protein
HHJ99_RS03125	COG1349	DNA-binding transcription factor activity
HHJ99_RS03130	COG0745	RESPONSE REGULATOR receiver
HHJ99_RS03135	COG5002	protein histidine kinase activity
HHJ99_RS03140	COG0567	Dehydrogenase, E1 component
HHJ99_RS03150	COG3177	Filamentation induced by cAMP protein fic
HHJ99_RS03155	COG1131	(ABC) transporter
HHJ99_RS03180	COG0714	Associated with various cellular activities
HHJ99_RS03185	COG4548	von Willebrand factor, type A
HHJ99_RS03190	COG1114	Component of the transport system for branched-chain amino acids
HHJ99_RS03195	COG3853	Toxic anion resistance protein (TelA)
HHJ99_RS03205	COG1254	Belongs to the acylphosphatase family
HHJ99_RS03215	COG1278	Cold shock
HHJ99_RS03230	COG1473	amidohydrolase
HHJ99_RS03235	COG2171	N-acyltransferase activity
HHJ99_RS03240	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HHJ99_RS03245	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HHJ99_RS03250	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HHJ99_RS03255	COG0527	aspartate kinase activity
HHJ99_RS03260	COG0488	(ABC) transporter
HHJ99_RS03265	COG2996	Protein conserved in bacteria
HHJ99_RS03285	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HHJ99_RS03290	COG0573	inorganic phosphate transmembrane transporter activity
HHJ99_RS03295	COG0581	inorganic phosphate transmembrane transporter activity
HHJ99_RS03300	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HHJ99_RS03305	COG0704	Plays a role in the regulation of phosphate uptake
HHJ99_RS03310	COG1164	Oligoendopeptidase f
HHJ99_RS03345	COG2348	transferase activity, transferring amino-acyl groups
HHJ99_RS03350	COG2348	transferase activity, transferring amino-acyl groups
HHJ99_RS03360	COG0159	tryptophan synthase activity
HHJ99_RS03365	COG0133	tryptophan synthase activity
HHJ99_RS03370	COG0135	phosphoribosylanthranilate isomerase activity
HHJ99_RS03375	COG0134	indole-3-glycerol-phosphate synthase activity
HHJ99_RS03380	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HHJ99_RS03385	COG0512	Glutamine amidotransferase of anthranilate synthase
HHJ99_RS03390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HHJ99_RS03395	COG1363	Peptidase, m42
HHJ99_RS03400	COG0287	Prephenate dehydrogenase
HHJ99_RS03405	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HHJ99_RS03410	COG1942	4-Oxalocrotonate Tautomerase
HHJ99_RS03425	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HHJ99_RS03425	COG0392	lysyltransferase activity
HHJ99_RS03430	COG0628	permease
HHJ99_RS03435	COG3711	transcriptional antiterminator
HHJ99_RS03440	COG1115	amino acid carrier protein
HHJ99_RS03445	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HHJ99_RS03450	COG0187	DNA topoisomerase II activity
HHJ99_RS03455	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HHJ99_RS03465	COG0824	Thioesterase
HHJ99_RS03470	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HHJ99_RS03475	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HHJ99_RS03480	COG1970	mechanosensitive ion channel activity
HHJ99_RS03485	COG0419	ATPase involved in DNA repair
HHJ99_RS03490	COG0420	3'-5' exonuclease activity
HHJ99_RS03495	COG4846	Membrane protein involved in cytochrome C biogenesis
HHJ99_RS03500	COG3763	UPF0154 protein
HHJ99_RS03505	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HHJ99_RS03510	COG4224	UPF0291 protein
HHJ99_RS03520	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HHJ99_RS03525	COG2340	Cysteine-rich secretory protein family
HHJ99_RS03530	COG0516	GMP reductase activity
HHJ99_RS03535	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HHJ99_RS03550	COG0833	amino acid
HHJ99_RS03565	COG0083	homoserine kinase activity
HHJ99_RS03570	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HHJ99_RS03575	COG0460	homoserine dehydrogenase
HHJ99_RS03580	COG0527	aspartate kinase activity
HHJ99_RS03595	COG1525	nuclease
HHJ99_RS03610	COG2197	response regulator
HHJ99_RS03615	COG4585	Histidine kinase
HHJ99_RS03625	COG1131	(ABC) transporter
HHJ99_RS03630	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HHJ99_RS03685	COG0174	glutamine synthetase
HHJ99_RS03690	COG0789	Transcriptional regulator
HHJ99_RS03695	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HHJ99_RS03700	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HHJ99_RS03705	COG0386	Belongs to the glutathione peroxidase family
HHJ99_RS03710	COG1923	regulation of RNA biosynthetic process
HHJ99_RS03715	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HHJ99_RS03725	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HHJ99_RS03730	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HHJ99_RS03735	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HHJ99_RS03740	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HHJ99_RS03745	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HHJ99_RS03750	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HHJ99_RS03760	COG4550	Control of competence regulator ComK, YlbF/YmcA
HHJ99_RS03765	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HHJ99_RS03775	COG4195	phage-related replication protein
HHJ99_RS03780	COG1013	pyruvate-flavodoxin oxidoreductase activity
HHJ99_RS03785	COG0674	pyruvate-flavodoxin oxidoreductase activity
HHJ99_RS03785	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HHJ99_RS03790	COG1692	metallophosphoesterase
HHJ99_RS03800	COG1418	mRNA catabolic process
HHJ99_RS03805	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HHJ99_RS03810	COG1546	Belongs to the CinA family
HHJ99_RS03810	COG1058	Belongs to the CinA family
HHJ99_RS03815	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HHJ99_RS03830	COG0300	oxidoreductase activity
HHJ99_RS03835	COG0612	Peptidase, M16
HHJ99_RS03840	COG0612	Peptidase, M16
HHJ99_RS03845	COG2188	Transcriptional regulator
HHJ99_RS03850	COG1674	ftsk spoiiie
HHJ99_RS03855	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HHJ99_RS03860	COG1185	polyribonucleotide nucleotidyltransferase activity
HHJ99_RS03865	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HHJ99_RS03870	COG0196	riboflavin kinase activity
HHJ99_RS03875	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HHJ99_RS03880	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HHJ99_RS03885	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HHJ99_RS03895	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HHJ99_RS03900	COG0195	Participates in both transcription termination and antitermination
HHJ99_RS03905	COG0779	Required for maturation of 30S ribosomal subunits
HHJ99_RS03910	COG2176	DNA-directed DNA polymerase activity
HHJ99_RS03915	COG0442	prolyl-tRNA aminoacylation
HHJ99_RS03925	COG4589	Belongs to the CDS family
HHJ99_RS03930	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HHJ99_RS03935	COG0233	cytoplasmic translational termination
HHJ99_RS03940	COG0528	UMP kinase activity
HHJ99_RS03945	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HHJ99_RS03950	COG0052	Belongs to the universal ribosomal protein uS2 family
HHJ99_RS03965	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HHJ99_RS03970	COG4974	Belongs to the 'phage' integrase family
HHJ99_RS03975	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HHJ99_RS03980	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HHJ99_RS03985	COG0758	DNA mediated transformation
HHJ99_RS03990	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HHJ99_RS03995	COG0045	succinate-CoA ligase (ADP-forming) activity
HHJ99_RS04000	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HHJ99_RS04010	COG4485	Bacterial membrane protein, YfhO
HHJ99_RS04020	COG0335	large ribosomal subunit rRNA binding
HHJ99_RS04025	COG0336	Belongs to the RNA methyltransferase TrmD family
HHJ99_RS04030	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HHJ99_RS04035	COG0228	four-way junction DNA binding
HHJ99_RS04040	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HHJ99_RS04045	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HHJ99_RS04050	COG0552	protein localization to endoplasmic reticulum
HHJ99_RS04055	COG1196	nuclear chromosome segregation
HHJ99_RS04060	COG0571	ribonuclease III activity
HHJ99_RS04065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HHJ99_RS04080	COG0416	fatty acid biosynthetic process
HHJ99_RS04085	COG1349	DNA-binding transcription factor activity
HHJ99_RS04090	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HHJ99_RS04105	COG1461	Dihydroxyacetone kinase
HHJ99_RS04110	COG1302	Protein conserved in bacteria
HHJ99_RS04115	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HHJ99_RS04120	COG1564	THIamine pyrophosphokinase
HHJ99_RS04125	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HHJ99_RS04130	COG1162	GTPase activity
HHJ99_RS04135	COG2807	transmembrane transport
HHJ99_RS04145	COG0631	protein serine/threonine phosphatase activity
HHJ99_RS04150	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HHJ99_RS04155	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HHJ99_RS04155	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HHJ99_RS04160	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HHJ99_RS04165	COG0242	peptide deformylase activity
HHJ99_RS04180	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HHJ99_RS04185	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HHJ99_RS04190	COG1758	RNA polymerase activity
HHJ99_RS04195	COG0194	GDP metabolic process
HHJ99_RS04200	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HHJ99_RS04215	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HHJ99_RS04220	COG0284	orotidine-5'-phosphate decarboxylase activity
HHJ99_RS04225	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HHJ99_RS04230	COG0505	Belongs to the CarA family
HHJ99_RS04235	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HHJ99_RS04240	COG0540	Belongs to the ATCase OTCase family
HHJ99_RS04245	COG2233	PERMEase
HHJ99_RS04250	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HHJ99_RS04255	COG0564	pseudouridine synthase activity
HHJ99_RS04260	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HHJ99_RS04275	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HHJ99_RS04280	COG3599	regulation of cell shape
HHJ99_RS04290	COG0762	integral membrane protein
HHJ99_RS04295	COG1799	cell septum assembly
HHJ99_RS04300	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HHJ99_RS04310	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HHJ99_RS04315	COG0849	cell division
HHJ99_RS04320	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HHJ99_RS04325	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HHJ99_RS04330	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HHJ99_RS04340	COG4839	cell division protein FtsL
HHJ99_RS04345	COG0275	rRNA processing
HHJ99_RS04355	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HHJ99_RS04360	COG0454	-acetyltransferase
HHJ99_RS04365	COG1011	Hydrolase
HHJ99_RS04400	COG1388	LysM domain
HHJ99_RS04400	COG0860	N-Acetylmuramoyl-L-alanine amidase
HHJ99_RS04565	COG0756	dUTP diphosphatase activity
HHJ99_RS04625	COG1484	DNA-dependent DNA replication
HHJ99_RS04715	COG3561	AntA/AntB antirepressor
HHJ99_RS04725	COG1396	sequence-specific DNA binding
HHJ99_RS04740	COG0582	viral genome integration into host DNA
HHJ99_RS04750	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HHJ99_RS04755	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HHJ99_RS04760	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HHJ99_RS04765	COG1053	succinate dehydrogenase
HHJ99_RS04770	COG2009	succinate dehydrogenase
HHJ99_RS04775	COG0322	excinuclease ABC activity
HHJ99_RS04780	COG3118	belongs to the thioredoxin family
HHJ99_RS04785	COG1193	negative regulation of DNA recombination
HHJ99_RS04790	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HHJ99_RS04790	COG1796	DNA polymerase
HHJ99_RS04800	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HHJ99_RS04805	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HHJ99_RS04810	COG0072	phenylalanine-tRNA ligase activity
HHJ99_RS04810	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HHJ99_RS04815	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HHJ99_RS04820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HHJ99_RS04830	COG4509	Sortase family
HHJ99_RS04835	COG1120	ATPase activity
HHJ99_RS04860	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HHJ99_RS04860	COG4932	domain protein
HHJ99_RS04860	COG3583	domain protein
HHJ99_RS04875	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HHJ99_RS04890	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HHJ99_RS04895	COG0742	ribosomal rna small subunit methyltransferase
HHJ99_RS04905	COG4471	UPF0298 protein
HHJ99_RS04910	COG0584	glycerophosphoryl diester phosphodiesterase
HHJ99_RS04955	COG3679	Belongs to the UPF0342 family
HHJ99_RS04970	COG0109	protoheme IX farnesyltransferase activity
HHJ99_RS04975	COG1612	heme a metabolic process
HHJ99_RS04985	COG0772	Belongs to the SEDS family
HHJ99_RS04990	COG4838	Belongs to the UPF0358 family
HHJ99_RS04995	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HHJ99_RS05000	COG4896	Protein conserved in bacteria
HHJ99_RS05015	COG0483	inositol monophosphate 1-phosphatase activity
HHJ99_RS05020	COG4493	Belongs to the UPF0637 family
HHJ99_RS05025	COG1914	H( )-stimulated, divalent metal cation uptake system
HHJ99_RS05045	COG1177	transmembrane transport
HHJ99_RS05050	COG1176	ABC-type spermidine putrescine transport system, permease component I
HHJ99_RS05060	COG1396	sequence-specific DNA binding
HHJ99_RS05060	COG3800	Transcriptional regulator
HHJ99_RS05065	COG4476	Belongs to the UPF0223 family
HHJ99_RS05075	COG0508	dehydrogenase complex catalyzes the overall conversion of
HHJ99_RS05080	COG0022	dehydrogenase e1 component
HHJ99_RS05085	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HHJ99_RS05095	COG0242	peptide deformylase activity
HHJ99_RS05105	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HHJ99_RS05110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HHJ99_RS05115	COG0569	domain protein
HHJ99_RS05120	COG1294	oxidase, subunit
HHJ99_RS05125	COG1271	oxidase subunit
HHJ99_RS05140	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HHJ99_RS05150	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HHJ99_RS05165	COG4172	Belongs to the ABC transporter superfamily
HHJ99_RS05170	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HHJ99_RS05175	COG0151	Belongs to the GarS family
HHJ99_RS05180	COG0138	bifunctional purine biosynthesis protein purh
HHJ99_RS05185	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HHJ99_RS05190	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HHJ99_RS05195	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HHJ99_RS05200	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HHJ99_RS05205	COG0047	phosphoribosylformylglycinamidine synthase activity
HHJ99_RS05210	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HHJ99_RS05215	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HHJ99_RS05220	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HHJ99_RS05225	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HHJ99_RS05230	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HHJ99_RS05235	COG1017	nitric oxide dioxygenase activity
HHJ99_RS05235	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HHJ99_RS05245	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HHJ99_RS05250	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HHJ99_RS05275	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HHJ99_RS05280	COG1316	TRANSCRIPTIONal
HHJ99_RS05300	COG1846	Transcriptional regulator
HHJ99_RS05305	COG3594	Acyltransferase
HHJ99_RS05310	COG0436	Aminotransferase
HHJ99_RS05315	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HHJ99_RS05325	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HHJ99_RS05330	COG1169	isochorismate synthase
HHJ99_RS05335	COG1575	Belongs to the MenA family. Type 1 subfamily
HHJ99_RS05375	COG4873	Protein conserved in bacteria
HHJ99_RS05385	COG0737	Belongs to the 5'-nucleotidase family
HHJ99_RS05390	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HHJ99_RS05395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HHJ99_RS05400	COG0861	Integral membrane protein TerC family
HHJ99_RS05405	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HHJ99_RS05415	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HHJ99_RS05420	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HHJ99_RS05425	COG2814	Major facilitator Superfamily
HHJ99_RS05430	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HHJ99_RS05435	COG2382	esterase
HHJ99_RS05440	COG0628	permease
HHJ99_RS05450	COG0569	domain protein
HHJ99_RS05450	COG0475	glutathione-regulated potassium exporter activity
HHJ99_RS05455	COG2239	Acts as a magnesium transporter
HHJ99_RS05460	COG0564	pseudouridine synthase activity
HHJ99_RS05470	COG2357	RelA SpoT domain protein
HHJ99_RS05485	COG2346	COG2346, Truncated hemoglobins
HHJ99_RS05495	COG1164	Oligoendopeptidase f
HHJ99_RS05505	COG4862	establishment of competence for transformation
HHJ99_RS05510	COG1393	Belongs to the ArsC family
HHJ99_RS05515	COG0180	Tryptophanyl-tRNA synthetase
HHJ99_RS05520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HHJ99_RS05525	COG0601	transmembrane transport
HHJ99_RS05530	COG4608	Belongs to the ABC transporter superfamily
HHJ99_RS05535	COG0444	Belongs to the ABC transporter superfamily
HHJ99_RS05550	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HHJ99_RS05560	COG1881	PFAM PEBP family protein
HHJ99_RS05565	COG0542	response to heat
HHJ99_RS05580	COG0561	phosphatase activity
HHJ99_RS05585	COG0446	pyridine nucleotide-disulphide oxidoreductase
HHJ99_RS05595	COG0179	Fumarylacetoacetate (FAA) hydrolase
HHJ99_RS05600	COG1074	ATP-dependent DNA helicase activity
HHJ99_RS05605	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HHJ99_RS05620	COG0398	Pfam SNARE associated Golgi protein
HHJ99_RS05625	COG0166	Belongs to the GPI family
HHJ99_RS05630	COG0137	argininosuccinate synthase activity
HHJ99_RS05635	COG0165	Argininosuccinate lyase
HHJ99_RS05640	COG0584	glycerophosphoryl diester phosphodiesterase
HHJ99_RS05655	COG1902	pentaerythritol trinitrate reductase activity
HHJ99_RS05660	COG1098	S1 RNA binding domain
HHJ99_RS05665	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HHJ99_RS05675	COG2111	Na H antiporter
HHJ99_RS05675	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HHJ99_RS05680	COG2111	Na H antiporter
HHJ99_RS05685	COG1006	Multisubunit Na H antiporter MnhC subunit
HHJ99_RS05690	COG0651	ATP synthesis coupled electron transport
HHJ99_RS05695	COG1863	multisubunit Na H antiporter MnhE subunit
HHJ99_RS05700	COG2212	antiporter activity
HHJ99_RS05705	COG1320	monovalent cation:proton antiporter activity
HHJ99_RS05715	COG2050	protein possibly involved in aromatic compounds catabolism
HHJ99_RS05720	COG2056	Na+-H+ antiporter family
HHJ99_RS05725	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HHJ99_RS05730	COG1252	NADH dehydrogenase
HHJ99_RS05735	COG0316	Belongs to the HesB IscA family
HHJ99_RS05740	COG4844	belongs to the
HHJ99_RS05745	COG1252	NADH dehydrogenase
HHJ99_RS05750	COG4837	Protein of unknown function (DUF1462)
HHJ99_RS05755	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HHJ99_RS05760	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HHJ99_RS05770	COG1696	Membrane protein involved in D-alanine export
HHJ99_RS05775	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HHJ99_RS05790	COG0647	UMP catabolic process
HHJ99_RS05795	COG2445	Protein of unknown function DUF86
HHJ99_RS05805	COG4470	Protein conserved in bacteria
HHJ99_RS05810	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HHJ99_RS05815	COG0737	Belongs to the 5'-nucleotidase family
HHJ99_RS05820	COG0730	response to heat
HHJ99_RS05825	COG1801	Protein of unknown function DUF72
HHJ99_RS05830	COG2070	2-Nitropropane dioxygenase
HHJ99_RS05835	COG1253	flavin adenine dinucleotide binding
HHJ99_RS05920	COG1388	LysM domain
HHJ99_RS05920	COG3942	CHAP domain
HHJ99_RS05930	COG0719	Fe-S assembly protein
HHJ99_RS05935	COG0822	iron-sulfur transferase activity
HHJ99_RS05940	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HHJ99_RS05945	COG0719	Fe-S assembly protein
HHJ99_RS05950	COG0396	ATPase activity
HHJ99_RS05970	COG1464	Belongs to the NlpA lipoprotein family
HHJ99_RS05975	COG2011	ABC-type metal ion transport system permease component
HHJ99_RS05980	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HHJ99_RS05990	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HHJ99_RS05995	COG0509	glycine decarboxylation via glycine cleavage system
HHJ99_RS06000	COG1393	Belongs to the ArsC family
HHJ99_RS06005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HHJ99_RS06015	COG0710	3-dehydroquinate dehydratase activity
HHJ99_RS06020	COG1764	response to oxidative stress
HHJ99_RS06030	COG1279	arginine transmembrane transporter activity
HHJ99_RS06035	COG0406	alpha-ribazole phosphatase activity
HHJ99_RS06070	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HHJ99_RS06075	COG4195	phage-related replication protein
HHJ99_RS06100	COG1278	Cold shock
HHJ99_RS06150	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HHJ99_RS06155	COG0557	exoribonuclease II activity
HHJ99_RS06160	COG1647	Serine aminopeptidase, S33
HHJ99_RS06165	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HHJ99_RS06175	COG0148	phosphopyruvate hydratase activity
HHJ99_RS06180	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HHJ99_RS06185	COG0149	triose-phosphate isomerase activity
HHJ99_RS06190	COG0126	phosphoglycerate kinase activity
HHJ99_RS06195	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HHJ99_RS06220	COG1090	epimerase
HHJ99_RS06230	COG0740	serine-type endopeptidase activity
HHJ99_RS06240	COG1481	regulation of sporulation
HHJ99_RS06245	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HHJ99_RS06250	COG1660	Displays ATPase and GTPase activities
HHJ99_RS06255	COG0492	ferredoxin-NADP+ reductase activity
HHJ99_RS06270	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HHJ99_RS06275	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HHJ99_RS06280	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HHJ99_RS06285	COG0556	nucleotide-excision repair
HHJ99_RS06300	COG1388	LysM domain
HHJ99_RS06300	COG3942	CHAP domain
HHJ99_RS06310	COG0653	protein targeting
HHJ99_RS06320	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HHJ99_RS06325	COG1040	competence protein
HHJ99_RS06330	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HHJ99_RS06340	COG1739	Uncharacterized protein family UPF0029
HHJ99_RS06345	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HHJ99_RS06350	COG2199	diguanylate cyclase activity
HHJ99_RS06365	COG2195	Cleaves the N-terminal amino acid of tripeptides
HHJ99_RS06370	COG1929	Belongs to the glycerate kinase type-1 family
HHJ99_RS06390	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HHJ99_RS06405	COG4604	ABC transporter, ATP-binding protein
HHJ99_RS06410	COG4605	iron ion homeostasis
HHJ99_RS06415	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HHJ99_RS06420	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HHJ99_RS06425	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HHJ99_RS06430	COG1780	Probably involved in ribonucleotide reductase function
HHJ99_RS06440	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HHJ99_RS06445	COG3104	oligopeptide transport
HHJ99_RS06450	COG1597	lipid kinase activity
HHJ99_RS06460	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HHJ99_RS06465	COG1174	glycine betaine transport
HHJ99_RS06475	COG0514	ATP-dependent DNA helicase (RecQ)
HHJ99_RS06480	COG0488	(ABC) transporter
HHJ99_RS06490	COG1368	sulfuric ester hydrolase activity
HHJ99_RS06515	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HHJ99_RS06525	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HHJ99_RS06530	COG0720	synthase
HHJ99_RS06535	COG0602	queuosine metabolic process
HHJ99_RS06555	COG0745	RESPONSE REGULATOR receiver
HHJ99_RS06560	COG5002	protein histidine kinase activity
HHJ99_RS06565	COG0463	Glycosyl transferase, family 2
HHJ99_RS06570	COG0656	L-ascorbic acid biosynthetic process
HHJ99_RS06575	COG1253	flavin adenine dinucleotide binding
HHJ99_RS06580	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HHJ99_RS06585	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HHJ99_RS06585	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HHJ99_RS06585	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HHJ99_RS06590	COG1105	Belongs to the carbohydrate kinase PfkB family
HHJ99_RS06595	COG1349	DNA-binding transcription factor activity
HHJ99_RS06600	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HHJ99_RS06635	COG0471	metal ion transport
HHJ99_RS06640	COG0039	L-malate dehydrogenase activity
HHJ99_RS06650	COG0523	cobalamin synthesis protein
HHJ99_RS06660	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HHJ99_RS06665	COG4988	ABC transporter
HHJ99_RS06670	COG1968	undecaprenyl-diphosphatase activity
HHJ99_RS06680	COG1671	Belongs to the UPF0178 family
HHJ99_RS06685	COG1611	Belongs to the LOG family
HHJ99_RS06690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HHJ99_RS06715	COG2839	Protein conserved in bacteria
HHJ99_RS06720	COG2814	Major facilitator Superfamily
HHJ99_RS06725	COG0583	DNA-binding transcription factor activity
HHJ99_RS06740	COG0217	transcriptional regulatory protein
HHJ99_RS06750	COG4977	sequence-specific DNA binding
HHJ99_RS06750	COG1917	Cupin 2, conserved barrel domain protein
HHJ99_RS06760	COG1388	LysM domain
HHJ99_RS06760	COG3942	CHAP domain
HHJ99_RS06765	COG0306	phosphate transporter
HHJ99_RS06770	COG1392	Phosphate transport regulator
HHJ99_RS06775	COG0577	efflux transmembrane transporter activity
HHJ99_RS06780	COG1136	(ABC) transporter
HHJ99_RS06785	COG2205	protein histidine kinase activity
HHJ99_RS06790	COG0745	RESPONSE REGULATOR receiver
HHJ99_RS06795	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HHJ99_RS06810	COG3949	Membrane
HHJ99_RS06820	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HHJ99_RS06825	COG1461	Dihydroxyacetone kinase
HHJ99_RS06830	COG2376	Dihydroxyacetone kinase
HHJ99_RS06835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HHJ99_RS06840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HHJ99_RS06845	COG1120	ATPase activity
HHJ99_RS06850	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HHJ99_RS06860	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HHJ99_RS06865	COG1132	(ABC) transporter
HHJ99_RS06870	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HHJ99_RS06880	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HHJ99_RS06885	COG1682	transport, permease protein
HHJ99_RS06890	COG1134	teichoic acid transport
HHJ99_RS06895	COG5609	conserved protein (DUF2294)
HHJ99_RS06905	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HHJ99_RS06915	COG1321	iron dependent repressor
HHJ99_RS06920	COG1121	(ABC) transporter
HHJ99_RS06925	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HHJ99_RS06930	COG0803	Belongs to the bacterial solute-binding protein 9 family
HHJ99_RS06945	COG1320	monovalent cation:proton antiporter activity
HHJ99_RS06950	COG2212	antiporter activity
HHJ99_RS06955	COG1863	multisubunit Na H antiporter MnhE subunit
HHJ99_RS06960	COG0651	ATP synthesis coupled electron transport
HHJ99_RS06965	COG1006	Multisubunit Na H antiporter MnhC subunit
HHJ99_RS06970	COG2111	Na H antiporter
HHJ99_RS06975	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HHJ99_RS06975	COG2111	Na H antiporter
HHJ99_RS06980	COG0582	viral genome integration into host DNA
HHJ99_RS07010	COG0596	Alpha beta hydrolase
HHJ99_RS07025	COG2267	carboxylic ester hydrolase activity
HHJ99_RS07030	COG0546	phosphoglycolate phosphatase activity
HHJ99_RS07035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HHJ99_RS07040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HHJ99_RS07055	COG0789	Transcriptional regulator
HHJ99_RS07060	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HHJ99_RS07065	COG0018	arginyl-trna synthetase
HHJ99_RS07085	COG3875	lactate racemase activity
HHJ99_RS07090	COG1606	tRNA processing
HHJ99_RS07095	COG1691	(AIR) carboxylase
HHJ99_RS07100	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
HHJ99_RS07115	COG1078	dGTPase activity
HHJ99_RS07125	COG0655	NAD(P)H dehydrogenase (quinone) activity
HHJ99_RS07135	COG0667	Aldo Keto reductase
HHJ99_RS07150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HHJ99_RS07155	COG4844	belongs to the
HHJ99_RS07175	COG0095	Lipoate-protein ligase
HHJ99_RS07180	COG0280	phosphate acetyltransferase
HHJ99_RS07205	COG2363	Small membrane protein
HHJ99_RS07215	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HHJ99_RS07220	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HHJ99_RS07225	COG0351	phosphomethylpyrimidine kinase
HHJ99_RS07235	COG0477	Major facilitator Superfamily
HHJ99_RS07250	COG0183	Belongs to the thiolase family
HHJ99_RS07255	COG0318	PFAM AMP-dependent synthetase and ligase
HHJ99_RS07270	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HHJ99_RS07275	COG0363	glucosamine-6-phosphate deaminase activity
HHJ99_RS07285	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HHJ99_RS07295	COG2271	Major facilitator Superfamily
HHJ99_RS07305	COG0431	NADPH-dependent FMN reductase
HHJ99_RS07310	COG0561	phosphatase activity
HHJ99_RS07320	COG1428	Deoxynucleoside kinase
HHJ99_RS07325	COG1428	Deoxynucleoside kinase
HHJ99_RS07330	COG1028	Short-chain dehydrogenase reductase Sdr
HHJ99_RS07335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HHJ99_RS07340	COG0546	phosphoglycolate phosphatase activity
HHJ99_RS07345	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HHJ99_RS07355	COG0737	Belongs to the 5'-nucleotidase family
HHJ99_RS07360	COG1069	ribulokinase activity
HHJ99_RS07365	COG1063	alcohol dehydrogenase
HHJ99_RS07370	COG2814	Major facilitator Superfamily
HHJ99_RS07375	COG1349	DNA-binding transcription factor activity
HHJ99_RS07395	COG1473	amidohydrolase
HHJ99_RS07400	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HHJ99_RS07405	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HHJ99_RS07415	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HHJ99_RS07425	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HHJ99_RS07430	COG0085	RNA polymerase activity
HHJ99_RS07435	COG2813	Specifically methylates the guanine in position
HHJ99_RS07440	COG0222	ribosome binding
HHJ99_RS07445	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HHJ99_RS07450	COG0081	regulation of translation
HHJ99_RS07455	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HHJ99_RS07460	COG0250	Participates in transcription elongation, termination and antitermination
HHJ99_RS07465	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HHJ99_RS07470	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HHJ99_RS07480	COG3688	RNA-binding protein containing a PIN domain
HHJ99_RS07485	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HHJ99_RS07490	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HHJ99_RS07495	COG0215	cysteine-tRNA ligase activity
HHJ99_RS07500	COG1045	serine acetyltransferase
HHJ99_RS07505	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HHJ99_RS07510	COG4956	integral membrane protein (PIN domain superfamily)
HHJ99_RS07515	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HHJ99_RS07520	COG0542	response to heat
HHJ99_RS07525	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HHJ99_RS07530	COG3880	PFAM UvrB UvrC protein
HHJ99_RS07540	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HHJ99_RS07545	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HHJ99_RS07550	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HHJ99_RS07555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HHJ99_RS07640	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HHJ99_RS07645	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HHJ99_RS07650	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HHJ99_RS07655	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HHJ99_RS07665	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HHJ99_RS07670	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HHJ99_RS07675	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HHJ99_RS07685	COG0037	tRNA processing
HHJ99_RS07690	COG1098	S1 RNA binding domain
HHJ99_RS07700	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HHJ99_RS07705	COG3956	TIGRFAM MazG family protein
HHJ99_RS07710	COG2244	polysaccharide biosynthetic process
HHJ99_RS07715	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HHJ99_RS07720	COG0193	aminoacyl-tRNA hydrolase activity
HHJ99_RS07725	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HHJ99_RS07730	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HHJ99_RS07735	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HHJ99_RS07740	COG2088	sporulation resulting in formation of a cellular spore
HHJ99_RS07745	COG0251	oxidation-reduction process
HHJ99_RS07750	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HHJ99_RS07755	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HHJ99_RS07760	COG4466	Protein conserved in bacteria
HHJ99_RS07765	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HHJ99_RS07770	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HHJ99_RS07775	COG0084	hydrolase, TatD family'
HHJ99_RS07780	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HHJ99_RS07780	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HHJ99_RS07785	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HHJ99_RS07790	COG2827	Endonuclease containing a URI domain
HHJ99_RS07795	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HHJ99_RS07800	COG4467	Involved in initiation control of chromosome replication
HHJ99_RS07805	COG1774	PSP1 C-terminal conserved region
HHJ99_RS07810	COG0470	DNA polymerase III
HHJ99_RS07815	COG3870	Protein conserved in bacteria
HHJ99_RS07820	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HHJ99_RS07825	COG1982	Orn Lys Arg decarboxylase major
HHJ99_RS07850	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HHJ99_RS07855	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HHJ99_RS07860	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HHJ99_RS07875	COG2188	Transcriptional regulator
HHJ99_RS07880	COG0366	Alpha amylase catalytic
HHJ99_RS07885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HHJ99_RS07885	COG1263	PTS System
HHJ99_RS07895	COG0493	'glutamate synthase
HHJ99_RS07900	COG0067	glutamate synthase
HHJ99_RS07900	COG0069	glutamate synthase activity
HHJ99_RS07900	COG0070	glutamate synthase
HHJ99_RS07905	COG0583	DNA-binding transcription factor activity
HHJ99_RS07920	COG0456	acetyltransferase
HHJ99_RS07935	COG0438	transferase activity, transferring glycosyl groups
HHJ99_RS07940	COG3942	CHAP domain
HHJ99_RS07940	COG1388	LysM domain
HHJ99_RS07950	COG2011	ABC-type metal ion transport system permease component
HHJ99_RS07955	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HHJ99_RS07960	COG0626	cystathionine gamma-synthase activity
HHJ99_RS07965	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HHJ99_RS07980	COG0733	neurotransmitter:sodium symporter activity
HHJ99_RS07990	COG1647	Serine aminopeptidase, S33
HHJ99_RS08010	COG5609	conserved protein (DUF2294)
HHJ99_RS08015	COG3002	Belongs to the UPF0753 family
HHJ99_RS08020	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HHJ99_RS08040	COG2814	Major facilitator Superfamily
HHJ99_RS08045	COG0523	cobalamin synthesis protein
HHJ99_RS08055	COG2211	Major facilitator Superfamily
HHJ99_RS08065	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HHJ99_RS08080	COG0519	Catalyzes the synthesis of GMP from XMP
HHJ99_RS08080	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HHJ99_RS08085	COG0517	IMP dehydrogenase activity
HHJ99_RS08085	COG0516	GMP reductase activity
HHJ99_RS08090	COG2233	PERMEase
HHJ99_RS08095	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HHJ99_RS08110	COG5183	chlorophyll binding
HHJ99_RS08115	COG1823	symporter activity
HHJ99_RS08120	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HHJ99_RS08125	COG0778	Nitroreductase
HHJ99_RS08135	COG0450	alkyl hydroperoxide reductase
HHJ99_RS08140	COG3634	alkyl hydroperoxide reductase activity
HHJ99_RS08160	COG1280	lysine exporter protein (LysE YggA)
HHJ99_RS08210	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HHJ99_RS08220	COG0360	Binds together with S18 to 16S ribosomal RNA
HHJ99_RS08235	COG0012	GTP binding
HHJ99_RS08240	COG4481	Protein conserved in bacteria
HHJ99_RS08245	COG0668	transmembrane transport
HHJ99_RS08250	COG1475	DNA binding
HHJ99_RS08255	COG0626	cystathionine gamma-synthase activity
HHJ99_RS08260	COG0626	cystathionine gamma-synthase activity
HHJ99_RS08265	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HHJ99_RS08265	COG0646	methionine synthase
HHJ99_RS08270	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HHJ99_RS08280	COG0183	Belongs to the thiolase family
HHJ99_RS08295	COG1476	TRANSCRIPTIONal
HHJ99_RS08305	COG1131	(ABC) transporter
HHJ99_RS08315	COG2814	Major facilitator Superfamily
HHJ99_RS08360	COG1136	(ABC) transporter
HHJ99_RS08365	COG0577	efflux transmembrane transporter activity
HHJ99_RS08390	COG0577	efflux transmembrane transporter activity
HHJ99_RS08395	COG1136	(ABC) transporter
HHJ99_RS08400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HHJ99_RS08450	COG1475	DNA binding
HHJ99_RS08455	COG0357	Ribosomal RNA small subunit methyltransferase G
HHJ99_RS08460	COG0445	tRNA wobble uridine modification
HHJ99_RS08465	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HHJ99_RS08470	COG0594	ribonuclease P activity
HHJ99_RS08480	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HHJ99_RS08485	COG0592	DNA-directed DNA polymerase activity
HHJ99_RS08490	COG2501	S4 domain
HHJ99_RS08495	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HHJ99_RS08500	COG0187	DNA topoisomerase II activity
HHJ99_RS08505	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HHJ99_RS08510	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HHJ99_RS08525	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HHJ99_RS08535	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HHJ99_RS08545	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HHJ99_RS08550	COG0359	binds to the 23S rRNA
HHJ99_RS08555	COG0305	Participates in initiation and elongation during chromosome replication
HHJ99_RS08560	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HHJ99_RS08575	COG0745	RESPONSE REGULATOR receiver
HHJ99_RS08580	COG5002	protein histidine kinase activity
HHJ99_RS08585	COG4863	YycH protein
HHJ99_RS08595	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HHJ99_RS08600	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HHJ99_RS08630	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HHJ99_RS08645	COG0732	type I restriction modification DNA specificity domain
HHJ99_RS08685	COG1755	Isoprenylcysteine carboxyl methyltransferase
HHJ99_RS08690	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HHJ99_RS08725	COG1136	(ABC) transporter
HHJ99_RS08730	COG1959	2 iron, 2 sulfur cluster binding
HHJ99_RS08735	COG2910	NAD(P)H-binding
HHJ99_RS08810	COG0583	DNA-binding transcription factor activity
HHJ99_RS08895	COG0745	RESPONSE REGULATOR receiver
HHJ99_RS08900	COG2205	protein histidine kinase activity
HHJ99_RS08910	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HHJ99_RS08915	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HHJ99_RS08930	COG0747	negative chemotaxis
HHJ99_RS08935	COG0601	transmembrane transport
HHJ99_RS08945	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HHJ99_RS08950	COG1124	(ABC) transporter
HHJ99_RS08990	COG0601	transmembrane transport
HHJ99_RS09000	COG0444	Belongs to the ABC transporter superfamily
HHJ99_RS09005	COG1124	(ABC) transporter
HHJ99_RS09035	COG1114	Component of the transport system for branched-chain amino acids
HHJ99_RS09045	COG1288	antiporter activity
HHJ99_RS09055	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HHJ99_RS09065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HHJ99_RS09070	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HHJ99_RS09075	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HHJ99_RS09100	COG2814	Major facilitator Superfamily
HHJ99_RS09105	COG0583	DNA-binding transcription factor activity
HHJ99_RS09145	COG2814	Major facilitator Superfamily
HHJ99_RS09170	COG1012	belongs to the aldehyde dehydrogenase family
HHJ99_RS09190	COG2318	DinB family
HHJ99_RS09195	COG4221	oxidoreductase activity
HHJ99_RS09200	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HHJ99_RS09205	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
HHJ99_RS09210	COG2962	Rard protein
HHJ99_RS09215	COG2409	Drug exporters of the RND superfamily
HHJ99_RS09215	COG1033	growth of symbiont in host cell
HHJ99_RS09230	COG0471	metal ion transport
HHJ99_RS09245	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HHJ99_RS09265	COG3386	PFAM SMP-30 Gluconolaconase
HHJ99_RS09275	COG2353	YceI-like domain
HHJ99_RS09285	COG0579	oxidoreductase
HHJ99_RS09295	COG0693	protein deglycase activity
HHJ99_RS09305	COG1686	Belongs to the peptidase S11 family
HHJ99_RS09330	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HHJ99_RS09335	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HHJ99_RS09340	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HHJ99_RS09345	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HHJ99_RS09350	COG0131	Imidazoleglycerol-phosphate dehydratase
HHJ99_RS09355	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HHJ99_RS09360	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HHJ99_RS09365	COG0107	imidazoleglycerol-phosphate synthase activity
HHJ99_RS09370	COG0140	phosphoribosyl-ATP diphosphatase activity
HHJ99_RS09370	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HHJ99_RS09395	COG0726	polysaccharide deacetylase
HHJ99_RS09405	COG1215	transferase activity, transferring glycosyl groups
HHJ99_RS09425	COG2814	Major facilitator Superfamily
HHJ99_RS09435	COG0737	Belongs to the 5'-nucleotidase family
HHJ99_RS09450	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HHJ99_RS09455	COG3639	organic phosphonate transmembrane transporter activity
HHJ99_RS09465	COG0702	epimerase
HHJ99_RS09530	COG0604	alcohol dehydrogenase
HHJ99_RS09550	COG2409	Drug exporters of the RND superfamily
HHJ99_RS09565	COG0583	DNA-binding transcription factor activity
HHJ99_RS09570	COG3842	ATPase activity
HHJ99_RS09575	COG1840	ABC-type Fe3 transport system, periplasmic component
HHJ99_RS09580	COG1177	transmembrane transport
HHJ99_RS09585	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HHJ99_RS09595	COG1764	response to oxidative stress
HHJ99_RS09620	COG1705	Flagellar rod assembly protein muramidase FlgJ
HHJ99_RS09620	COG3942	CHAP domain
HHJ99_RS09630	COG1482	cell wall glycoprotein biosynthetic process
HHJ99_RS09635	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HHJ99_RS09635	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HHJ99_RS09635	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HHJ99_RS09640	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HHJ99_RS09640	COG3711	transcriptional antiterminator
HHJ99_RS09655	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HHJ99_RS09665	COG0732	type I restriction modification DNA specificity domain
HHJ99_RS09840	COG2235	arginine
HHJ99_RS09860	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HHJ99_RS09885	COG2843	Capsule synthesis protein
HHJ99_RS09905	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HHJ99_RS09910	COG3961	Belongs to the TPP enzyme family
HHJ99_RS09915	COG1846	Transcriptional regulator
HHJ99_RS09920	COG4195	phage-related replication protein
HHJ99_RS09925	COG4195	phage-related replication protein
HHJ99_RS09930	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HHJ99_RS10000	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HHJ99_RS10005	COG0110	maltose O-acetyltransferase activity
HHJ99_RS10010	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HHJ99_RS10015	COG1316	TRANSCRIPTIONal
HHJ99_RS10020	COG1785	Belongs to the alkaline phosphatase family
HHJ99_RS10035	COG2205	protein histidine kinase activity
HHJ99_RS10040	COG1136	(ABC) transporter
HHJ99_RS10055	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HHJ99_RS10080	COG1846	Transcriptional regulator
HHJ99_RS10090	COG0386	Belongs to the glutathione peroxidase family
HHJ99_RS10095	COG0175	sulfate reduction
HHJ99_RS10100	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HHJ99_RS10105	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HHJ99_RS10120	COG0730	response to heat
HHJ99_RS10125	COG2046	Belongs to the sulfate adenylyltransferase family
HHJ99_RS10130	COG0529	Catalyzes the synthesis of activated sulfate
HHJ99_RS10140	COG3942	CHAP domain
HHJ99_RS10150	COG1328	CTP reductase activity
HHJ99_RS10155	COG0602	queuosine metabolic process
HHJ99_RS10160	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HHJ99_RS10170	COG1510	regulation of RNA biosynthetic process
HHJ99_RS10175	COG1012	belongs to the aldehyde dehydrogenase family
HHJ99_RS10180	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HHJ99_RS10185	COG1473	amidohydrolase
HHJ99_RS10205	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HHJ99_RS10210	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HHJ99_RS10210	COG0574	Belongs to the PEP-utilizing enzyme family
HHJ99_RS10215	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HHJ99_RS10220	COG0579	oxidoreductase
HHJ99_RS10250	COG3588	fructose-bisphosphate aldolase
HHJ99_RS10260	COG0446	pyridine nucleotide-disulphide oxidoreductase
HHJ99_RS10295	COG0531	amino acid
HHJ99_RS10305	COG0583	DNA-binding transcription factor activity
HHJ99_RS10310	COG0039	L-malate dehydrogenase activity
HHJ99_RS10315	COG0028	Belongs to the TPP enzyme family
HHJ99_RS10320	COG3527	Alpha-acetolactate decarboxylase
HHJ99_RS10330	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HHJ99_RS10335	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HHJ99_RS10350	COG4640	response to antibiotic
HHJ99_RS10360	COG4640	response to antibiotic
HHJ99_RS10385	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HHJ99_RS10395	COG0167	dihydroorotate dehydrogenase activity
HHJ99_RS10400	COG3001	Fructosamine kinase
HHJ99_RS10415	COG0596	Alpha beta hydrolase
HHJ99_RS10460	COG1113	amino acid transport
HHJ99_RS10475	COG0741	lytic transglycosylase activity
HHJ99_RS10505	COG0436	Aminotransferase
HHJ99_RS10510	COG2608	mercury ion transmembrane transporter activity
HHJ99_RS10515	COG2217	Heavy metal translocating P-type atpase
HHJ99_RS10530	COG1028	Short-chain dehydrogenase reductase Sdr
HHJ99_RS10540	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HHJ99_RS10545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HHJ99_RS10550	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
HHJ99_RS10555	COG1012	belongs to the aldehyde dehydrogenase family
HHJ99_RS10590	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HHJ99_RS10595	COG3425	synthase
HHJ99_RS10615	COG0583	DNA-binding transcription factor activity
HHJ99_RS10620	COG1380	Effector of murein hydrolase LrgA
HHJ99_RS10625	COG1346	cytolysis
HHJ99_RS10630	COG0028	Belongs to the TPP enzyme family
HHJ99_RS10635	COG1263	PTS System
HHJ99_RS10635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HHJ99_RS10635	COG2190	(PTS) system
HHJ99_RS10655	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HHJ99_RS10660	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HHJ99_RS10665	COG0657	acetylesterase activity
HHJ99_RS10670	COG0697	spore germination
HHJ99_RS10675	COG1917	Cupin 2, conserved barrel domain protein
HHJ99_RS10675	COG2207	Transcriptional regulator
HHJ99_RS10685	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HHJ99_RS10695	COG2843	Capsule synthesis protein
HHJ99_RS10710	COG4975	Glucose uptake
HHJ99_RS10715	COG1869	D-ribose catabolic process
HHJ99_RS10725	COG1070	Carbohydrate kinase
HHJ99_RS10740	COG1760	l-serine dehydratase
HHJ99_RS10745	COG1760	l-serine dehydratase
HHJ99_RS10760	COG3764	Sortase (surface protein transpeptidase)
HHJ99_RS10765	COG0561	phosphatase activity
HHJ99_RS10770	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HHJ99_RS10775	COG0778	Nitroreductase
HHJ99_RS10780	COG1012	belongs to the aldehyde dehydrogenase family
HHJ99_RS10785	COG2514	catechol 2,3-dioxygenase activity
HHJ99_RS10800	COG1012	belongs to the aldehyde dehydrogenase family
HHJ99_RS10805	COG3949	Membrane
HHJ99_RS10815	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HHJ99_RS10820	COG0586	Pfam SNARE associated Golgi protein
HHJ99_RS10825	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HHJ99_RS10830	COG2022	thiamine diphosphate biosynthetic process
HHJ99_RS10840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HHJ99_RS10850	COG2271	Major facilitator Superfamily
HHJ99_RS10865	COG4876	unkown
HHJ99_RS10870	COG2357	RelA SpoT domain protein
HHJ99_RS10885	COG1802	Transcriptional regulator
HHJ99_RS10890	COG1070	Carbohydrate kinase
HHJ99_RS10895	COG2610	gluconate transmembrane transporter activity
HHJ99_RS10900	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HHJ99_RS10905	COG1216	Glycosyl transferase, family 2
HHJ99_RS10920	COG4221	oxidoreductase activity
HHJ99_RS10925	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HHJ99_RS10930	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HHJ99_RS10935	COG0248	Ppx GppA phosphatase
HHJ99_RS10940	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HHJ99_RS10945	COG1028	Short-chain dehydrogenase reductase Sdr
HHJ99_RS10955	COG1363	Peptidase, m42
HHJ99_RS10960	COG4808	Protein conserved in bacteria
HHJ99_RS10965	COG0069	glutamate synthase activity
HHJ99_RS10980	COG4619	ABC transporter
HHJ99_RS10985	COG0390	transport system, permease component
HHJ99_RS10990	COG2205	protein histidine kinase activity
HHJ99_RS10995	COG0745	RESPONSE REGULATOR receiver
HHJ99_RS11005	COG2814	Major facilitator Superfamily
HHJ99_RS11010	COG2272	Belongs to the type-B carboxylesterase lipase family
HHJ99_RS11015	COG0531	amino acid
HHJ99_RS11020	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
HHJ99_RS11025	COG1063	alcohol dehydrogenase
HHJ99_RS11045	COG1174	glycine betaine transport
HHJ99_RS11050	COG1346	cytolysis
HHJ99_RS11055	COG1380	Effector of murein hydrolase LrgA
HHJ99_RS11065	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HHJ99_RS11080	COG0706	membrane insertase activity
HHJ99_RS11090	COG0531	amino acid
HHJ99_RS11100	COG1113	amino acid transport
HHJ99_RS11120	COG2814	Major facilitator Superfamily
HHJ99_RS11130	COG1929	Belongs to the glycerate kinase type-1 family
HHJ99_RS11145	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HHJ99_RS11150	COG0588	phosphoglycerate mutase activity
HHJ99_RS11160	COG2814	Major facilitator Superfamily
HHJ99_RS11165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HHJ99_RS11170	COG0765	amino acid transport
HHJ99_RS11175	COG1126	abc transporter atp-binding protein
HHJ99_RS11185	COG2348	transferase activity, transferring amino-acyl groups
HHJ99_RS11215	COG2116	formate transmembrane transporter activity
HHJ99_RS11220	COG0454	-acetyltransferase
HHJ99_RS11225	COG0747	negative chemotaxis
HHJ99_RS11230	COG2226	methyltransferase
HHJ99_RS11240	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HHJ99_RS11245	COG2146	nitrite reductase [NAD(P)H] activity
HHJ99_RS11255	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HHJ99_RS11260	COG1140	nitrate reductase beta subunit
HHJ99_RS11270	COG2181	nitrate reductase activity
HHJ99_RS11280	COG4585	Histidine kinase
HHJ99_RS11285	COG2197	response regulator
HHJ99_RS11290	COG2223	nitrite transmembrane transporter activity
HHJ99_RS11300	COG1846	Transcriptional regulator
HHJ99_RS11305	COG0778	Nitroreductase
HHJ99_RS11360	COG1028	Short-chain dehydrogenase reductase Sdr
HHJ99_RS11370	COG0534	Mate efflux family protein
HHJ99_RS11390	COG0492	ferredoxin-NADP+ reductase activity
HHJ99_RS11400	COG0604	alcohol dehydrogenase
HHJ99_RS11405	COG2822	iron ion transport
HHJ99_RS11415	COG0672	)-iron permease
HHJ99_RS11420	COG0805	protein transport
HHJ99_RS11425	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HHJ99_RS11430	COG0456	acetyltransferase
HHJ99_RS11435	COG0463	Glycosyl transferase, family 2
HHJ99_RS11435	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HHJ99_RS11445	COG0463	Glycosyl transferase, family 2
HHJ99_RS11445	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HHJ99_RS11450	COG1620	l-lactate permease
HHJ99_RS11460	COG0579	oxidoreductase
HHJ99_RS11465	COG3850	Histidine kinase
HHJ99_RS11465	COG5002	protein histidine kinase activity
HHJ99_RS11470	COG0745	RESPONSE REGULATOR receiver
HHJ99_RS11475	COG0577	efflux transmembrane transporter activity
HHJ99_RS11480	COG1136	(ABC) transporter
HHJ99_RS11495	COG4640	response to antibiotic
HHJ99_RS11500	COG2814	Major facilitator Superfamily
HHJ99_RS11510	COG1566	PFAM secretion protein HlyD family protein
HHJ99_RS11515	COG2814	Major facilitator Superfamily
HHJ99_RS11540	COG0598	Magnesium transport protein CorA
HHJ99_RS11545	COG1304	FMN binding
HHJ99_RS11550	COG0786	glutamate:sodium symporter activity
HHJ99_RS11555	COG2094	Belongs to the DNA glycosylase MPG family
HHJ99_RS11560	COG3152	Membrane
HHJ99_RS11575	COG1069	ribulokinase activity
HHJ99_RS11580	COG4152	abc transporter atp-binding protein
HHJ99_RS11585	COG1668	transmembrane transport
HHJ99_RS11590	COG1742	UPF0060 membrane protein
HHJ99_RS11595	COG2017	converts alpha-aldose to the beta-anomer
HHJ99_RS11600	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HHJ99_RS11605	COG1266	CAAX protease self-immunity
HHJ99_RS11610	COG0010	Belongs to the arginase family
HHJ99_RS11630	COG1473	amidohydrolase
HHJ99_RS11635	COG1028	Short-chain dehydrogenase reductase Sdr
HHJ99_RS11655	COG1737	Transcriptional regulator
HHJ99_RS11660	COG1263	PTS System
HHJ99_RS11660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HHJ99_RS11670	COG0385	Bile acid
HHJ99_RS11675	COG0546	phosphoglycolate phosphatase activity
HHJ99_RS11695	COG1113	amino acid transport
HHJ99_RS11705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HHJ99_RS11705	COG1263	PTS System
HHJ99_RS11710	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HHJ99_RS11730	COG2378	regulation of single-species biofilm formation
HHJ99_RS11740	COG1316	TRANSCRIPTIONal
HHJ99_RS11770	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HHJ99_RS11775	COG2076	Multidrug Resistance protein
HHJ99_RS11780	COG2076	Multidrug Resistance protein
HHJ99_RS11785	COG3942	CHAP domain
HHJ99_RS11800	COG1757	Na H antiporter
HHJ99_RS11805	COG3942	CHAP domain
HHJ99_RS11815	COG1846	Transcriptional regulator
HHJ99_RS11830	COG0829	nickel cation binding
HHJ99_RS11840	COG0830	nickel cation binding
HHJ99_RS11845	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HHJ99_RS11850	COG0804	urea catabolic process
HHJ99_RS11855	COG0832	Belongs to the urease beta subunit family
HHJ99_RS11860	COG0831	urea catabolic process
HHJ99_RS11865	COG4413	Urea transporter
HHJ99_RS11870	COG1960	acyl-CoA dehydrogenase activity
HHJ99_RS11875	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HHJ99_RS11885	COG1268	BioY protein
HHJ99_RS11895	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HHJ99_RS11900	COG0725	ABC transporter, periplasmic molybdate-binding protein
HHJ99_RS11905	COG4149	molybdate abc transporter
HHJ99_RS11910	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HHJ99_RS11915	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HHJ99_RS11920	COG0521	Mo-molybdopterin cofactor biosynthetic process
HHJ99_RS11925	COG0315	cyclic pyranopterin monophosphate synthase activity
HHJ99_RS11930	COG0303	'Molybdopterin
HHJ99_RS11950	COG0746	molybdenum cofactor guanylyltransferase activity
HHJ99_RS11955	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HHJ99_RS11965	COG2814	Major facilitator Superfamily
HHJ99_RS11980	COG2348	transferase activity, transferring amino-acyl groups
HHJ99_RS11985	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HHJ99_RS12015	COG4975	Glucose uptake
HHJ99_RS12025	COG0551	DNA topoisomerase type I activity
HHJ99_RS12025	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HHJ99_RS12030	COG2252	PERMEase
HHJ99_RS12045	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HHJ99_RS12050	COG0088	Forms part of the polypeptide exit tunnel
HHJ99_RS12055	COG0089	rRNA binding
HHJ99_RS12060	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HHJ99_RS12065	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HHJ99_RS12080	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HHJ99_RS12090	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HHJ99_RS12095	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HHJ99_RS12100	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HHJ99_RS12105	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HHJ99_RS12110	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HHJ99_RS12115	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HHJ99_RS12120	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HHJ99_RS12125	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HHJ99_RS12130	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HHJ99_RS12135	COG1841	ribosomal large subunit assembly
HHJ99_RS12140	COG0200	Binds to the 23S rRNA
HHJ99_RS12145	COG0201	protein transport
HHJ99_RS12150	COG0563	adenylate kinase activity
HHJ99_RS12155	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HHJ99_RS12160	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HHJ99_RS12165	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HHJ99_RS12175	COG0202	RNA polymerase activity
HHJ99_RS12180	COG0203	ribosomal protein L17
HHJ99_RS12185	COG1122	ATPase activity
HHJ99_RS12190	COG1122	ATPase activity
HHJ99_RS12200	COG0101	tRNA pseudouridine synthase activity
HHJ99_RS12205	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HHJ99_RS12215	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HHJ99_RS12220	COG1349	DNA-binding transcription factor activity
HHJ99_RS12225	COG0698	ribose 5-phosphate isomerase
HHJ99_RS12250	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HHJ99_RS12250	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HHJ99_RS12255	COG2723	6-phospho-beta-galactosidase activity
HHJ99_RS12265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HHJ99_RS12270	COG2130	NADP-dependent
HHJ99_RS12275	COG0604	alcohol dehydrogenase
HHJ99_RS12290	COG1302	Protein conserved in bacteria
HHJ99_RS12295	COG4264	IucA IucC family
HHJ99_RS12300	COG2814	Major facilitator Superfamily
HHJ99_RS12305	COG4264	IucA IucC family
HHJ99_RS12310	COG3457	Alanine racemase
HHJ99_RS12315	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HHJ99_RS12320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HHJ99_RS12325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HHJ99_RS12335	COG2329	Antibiotic biosynthesis monooxygenase
HHJ99_RS12345	COG1988	membrane-bound metal-dependent
HHJ99_RS12350	COG4284	Utp--glucose-1-phosphate uridylyltransferase
HHJ99_RS12370	COG2814	Major facilitator Superfamily
HHJ99_RS12375	COG0489	protein tyrosine kinase activity
HHJ99_RS12430	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HHJ99_RS12440	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HHJ99_RS12455	COG3711	transcriptional antiterminator
HHJ99_RS12465	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HHJ99_RS12470	COG0561	phosphatase activity
HHJ99_RS12490	COG0640	Transcriptional regulator
HHJ99_RS12495	COG0702	epimerase
HHJ99_RS12500	COG1482	cell wall glycoprotein biosynthetic process
HHJ99_RS12520	COG0783	Belongs to the Dps family
HHJ99_RS12530	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HHJ99_RS12535	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HHJ99_RS12540	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HHJ99_RS12550	COG1854	S-ribosylhomocysteine lyase activity
HHJ99_RS12925	COG1192	Involved in chromosome partitioning
HHJ99_RS12985	COG0542	response to heat
HHJ99_RS13080	COG1674	ftsk spoiiie
HHJ99_RS13170	COG1192	Involved in chromosome partitioning
HHJ99_RS13180	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HHJ99_RS13185	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HHJ99_RS13195	COG0446	pyridine nucleotide-disulphide oxidoreductase
HHJ99_RS13215	COG0640	Transcriptional regulator
HHJ99_RS13245	COG0693	protein deglycase activity
HHJ99_RS13250	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HHJ99_RS13255	COG1733	regulation of RNA biosynthetic process
HHJ99_RS13260	COG0579	oxidoreductase
HHJ99_RS13285	COG2348	transferase activity, transferring amino-acyl groups
HHJ99_RS13325	COG3682	Transcriptional regulator
HHJ99_RS13380	COG0706	membrane insertase activity
HHJ99_RS13500	COG2217	Heavy metal translocating P-type atpase
HHJ99_RS13505	COG1937	Protein conserved in bacteria
HHJ99_RS13630	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HHJ99_RS13645	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HHJ99_RS13655	COG1733	regulation of RNA biosynthetic process
HHJ99_RS13680	COG1131	(ABC) transporter