locus-tag	class	description
A7E59_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A7E59_RS00010	COG0592	DNA-directed DNA polymerase activity
A7E59_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A7E59_RS00025	COG0187	DNA topoisomerase II activity
A7E59_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A7E59_RS00050	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A7E59_RS00070	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
A7E59_RS00075	COG0359	binds to the 23S rRNA
A7E59_RS00080	COG0305	Participates in initiation and elongation during chromosome replication
A7E59_RS00090	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A7E59_RS00105	COG0745	RESPONSE REGULATOR receiver
A7E59_RS00115	COG4863	YycH protein
A7E59_RS00125	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A7E59_RS00130	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A7E59_RS00135	COG1002	Type II restriction enzyme, methylase subunits
A7E59_RS00140	COG1061	Type III restriction enzyme res subunit
A7E59_RS00145	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A7E59_RS00175	COG1012	belongs to the aldehyde dehydrogenase family
A7E59_RS00230	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A7E59_RS00235	COG2610	gluconate transmembrane transporter activity
A7E59_RS00250	COG0813	purine-nucleoside phosphorylase activity
A7E59_RS00255	COG2814	Major facilitator Superfamily
A7E59_RS00260	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A7E59_RS00285	COG1028	Short-chain dehydrogenase reductase Sdr
A7E59_RS00290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7E59_RS00320	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A7E59_RS00340	COG2003	Belongs to the UPF0758 family
A7E59_RS00380	COG1215	transferase activity, transferring glycosyl groups
A7E59_RS00380	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A7E59_RS00385	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A7E59_RS00385	COG1215	transferase activity, transferring glycosyl groups
A7E59_RS00395	COG1216	Glycosyl transferase, family 2
A7E59_RS00400	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A7E59_RS00490	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A7E59_RS00495	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A7E59_RS00500	COG0438	transferase activity, transferring glycosyl groups
A7E59_RS00525	COG1705	Flagellar rod assembly protein muramidase FlgJ
A7E59_RS00525	COG3942	CHAP domain
A7E59_RS00555	COG0698	ribose 5-phosphate isomerase
A7E59_RS00560	COG1494	fructose-1,6-bisphosphatase
A7E59_RS00570	COG0183	Belongs to the thiolase family
A7E59_RS00580	COG1960	acyl-CoA dehydrogenase activity
A7E59_RS00585	COG0318	PFAM AMP-dependent synthetase and ligase
A7E59_RS00610	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A7E59_RS00615	COG1280	lysine exporter protein (LysE YggA)
A7E59_RS00650	COG0598	Magnesium transport protein CorA
A7E59_RS00665	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
A7E59_RS00670	COG0517	IMP dehydrogenase activity
A7E59_RS00670	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A7E59_RS00680	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A7E59_RS00685	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A7E59_RS00700	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A7E59_RS00710	COG2226	methyltransferase
A7E59_RS00730	COG0778	Nitroreductase
A7E59_RS00785	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A7E59_RS00810	COG1028	Short-chain dehydrogenase reductase Sdr
A7E59_RS00820	COG1012	belongs to the aldehyde dehydrogenase family
A7E59_RS00850	COG1472	Belongs to the glycosyl hydrolase 3 family
A7E59_RS00860	COG0730	response to heat
A7E59_RS00875	COG0753	catalase activity
A7E59_RS00895	COG0446	pyridine nucleotide-disulphide oxidoreductase
A7E59_RS00895	COG1902	pentaerythritol trinitrate reductase activity
A7E59_RS00955	COG1054	Belongs to the UPF0176 family
A7E59_RS00985	COG0346	lactoylglutathione lyase activity
A7E59_RS01005	COG0789	Transcriptional regulator
A7E59_RS01015	COG0477	Major facilitator Superfamily
A7E59_RS01030	COG0667	Aldo Keto reductase
A7E59_RS01040	COG1028	Short-chain dehydrogenase reductase Sdr
A7E59_RS01050	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A7E59_RS01085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7E59_RS01090	COG1028	Short-chain dehydrogenase reductase Sdr
A7E59_RS01115	COG1288	antiporter activity
A7E59_RS01125	COG3871	stress protein (general stress protein 26)
A7E59_RS01130	COG1929	Belongs to the glycerate kinase type-1 family
A7E59_RS01140	COG1511	domain protein
A7E59_RS01150	COG0604	alcohol dehydrogenase
A7E59_RS01165	COG0579	oxidoreductase
A7E59_RS01170	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A7E59_RS01185	COG0561	phosphatase activity
A7E59_RS01190	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A7E59_RS01195	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A7E59_RS01220	COG1396	sequence-specific DNA binding
A7E59_RS01225	COG1288	antiporter activity
A7E59_RS01235	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A7E59_RS01255	COG0706	membrane insertase activity
A7E59_RS01275	COG0583	DNA-binding transcription factor activity
A7E59_RS01280	COG3842	ATPase activity
A7E59_RS01285	COG1840	ABC-type Fe3 transport system, periplasmic component
A7E59_RS01320	COG1028	Short-chain dehydrogenase reductase Sdr
A7E59_RS01345	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A7E59_RS01350	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A7E59_RS01365	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A7E59_RS01400	COG0069	glutamate synthase activity
A7E59_RS01405	COG2814	Major facilitator Superfamily
A7E59_RS01410	COG2822	iron ion transport
A7E59_RS01420	COG0672	)-iron permease
A7E59_RS01425	COG0805	protein transport
A7E59_RS01430	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A7E59_RS01440	COG0753	catalase activity
A7E59_RS01450	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A7E59_RS01485	COG0201	protein transport
A7E59_RS01495	COG1073	alpha beta
A7E59_RS01520	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A7E59_RS01535	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A7E59_RS01535	COG3583	domain protein
A7E59_RS01535	COG4932	domain protein
A7E59_RS01560	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A7E59_RS01565	COG2011	ABC-type metal ion transport system permease component
A7E59_RS01600	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A7E59_RS01605	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
A7E59_RS01620	COG0463	Glycosyl transferase, family 2
A7E59_RS01620	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A7E59_RS01625	COG1511	domain protein
A7E59_RS01660	COG2210	Belongs to the sulfur carrier protein TusA family
A7E59_RS01680	COG3961	Belongs to the TPP enzyme family
A7E59_RS01690	COG1510	regulation of RNA biosynthetic process
A7E59_RS01695	COG1012	belongs to the aldehyde dehydrogenase family
A7E59_RS01700	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
A7E59_RS01705	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A7E59_RS01710	COG1181	Belongs to the D-alanine--D-alanine ligase family
A7E59_RS01740	COG1368	sulfuric ester hydrolase activity
A7E59_RS01755	COG0463	Glycosyl transferase, family 2
A7E59_RS01755	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A7E59_RS01765	COG0494	nUDIX hydrolase
A7E59_RS01775	COG0563	adenylate kinase activity
A7E59_RS01785	COG3588	fructose-bisphosphate aldolase
A7E59_RS01790	COG2258	MOSC domain
A7E59_RS01815	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A7E59_RS01820	COG1263	PTS System
A7E59_RS01820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7E59_RS01825	COG1737	Transcriptional regulator
A7E59_RS01870	COG0582	viral genome integration into host DNA
A7E59_RS01875	COG2111	Na H antiporter
A7E59_RS01875	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A7E59_RS01880	COG2111	Na H antiporter
A7E59_RS01885	COG1006	Multisubunit Na H antiporter MnhC subunit
A7E59_RS01895	COG1863	multisubunit Na H antiporter MnhE subunit
A7E59_RS01900	COG2212	antiporter activity
A7E59_RS01905	COG1320	monovalent cation:proton antiporter activity
A7E59_RS01920	COG1113	amino acid transport
A7E59_RS01935	COG1131	(ABC) transporter
A7E59_RS01945	COG2824	Alkylphosphonate utilization operon protein PhnA
A7E59_RS01955	COG2376	Dihydroxyacetone kinase
A7E59_RS01960	COG1461	Dihydroxyacetone kinase
A7E59_RS01970	COG0438	transferase activity, transferring glycosyl groups
A7E59_RS01975	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A7E59_RS01975	COG0463	Glycosyl transferase, family 2
A7E59_RS01980	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A7E59_RS01990	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A7E59_RS01990	COG0463	Glycosyl transferase, family 2
A7E59_RS01995	COG0531	amino acid
A7E59_RS02010	COG0463	Glycosyl transferase, family 2
A7E59_RS02015	COG0446	pyridine nucleotide-disulphide oxidoreductase
A7E59_RS02025	COG1959	2 iron, 2 sulfur cluster binding
A7E59_RS02030	COG1131	(ABC) transporter
A7E59_RS02050	COG1028	Short-chain dehydrogenase reductase Sdr
A7E59_RS02075	COG0318	PFAM AMP-dependent synthetase and ligase
A7E59_RS02080	COG0183	Belongs to the thiolase family
A7E59_RS02090	COG2235	arginine
A7E59_RS02095	COG2235	arginine
A7E59_RS02105	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A7E59_RS02110	COG1438	arginine binding
A7E59_RS02120	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A7E59_RS02125	COG2022	thiamine diphosphate biosynthetic process
A7E59_RS02135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7E59_RS02140	COG0352	thiamine-phosphate diphosphorylase activity
A7E59_RS02155	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
A7E59_RS02160	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A7E59_RS02165	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A7E59_RS02185	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A7E59_RS02200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A7E59_RS02210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A7E59_RS02220	COG1953	Uracil, thiamine, allantoin
A7E59_RS02225	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A7E59_RS02240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A7E59_RS02245	COG3257	ureidoglycine aminohydrolase activity
A7E59_RS02250	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A7E59_RS02255	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A7E59_RS02260	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A7E59_RS02265	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A7E59_RS02280	COG2807	transmembrane transport
A7E59_RS02290	COG5646	InterPro IPR014922
A7E59_RS02305	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A7E59_RS02310	COG1984	allophanate hydrolase subunit 2
A7E59_RS02320	COG0439	Biotin carboxylase
A7E59_RS02325	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A7E59_RS02330	COG1914	H( )-stimulated, divalent metal cation uptake system
A7E59_RS02335	COG1070	Carbohydrate kinase
A7E59_RS02365	COG1695	Transcriptional regulator
A7E59_RS02395	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A7E59_RS02410	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A7E59_RS02425	COG3189	MarR family transcriptional regulator
A7E59_RS02435	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A7E59_RS02450	COG0604	alcohol dehydrogenase
A7E59_RS02455	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
A7E59_RS02460	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A7E59_RS02470	COG3001	Fructosamine kinase
A7E59_RS02485	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A7E59_RS02500	COG3764	Sortase (surface protein transpeptidase)
A7E59_RS02505	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A7E59_RS02515	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A7E59_RS02535	COG1136	(ABC) transporter
A7E59_RS02545	COG0583	DNA-binding transcription factor activity
A7E59_RS02560	COG0028	Belongs to the TPP enzyme family
A7E59_RS02570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A7E59_RS02580	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A7E59_RS02585	COG1687	branched-chain amino acid
A7E59_RS02590	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
A7E59_RS02615	COG1760	l-serine dehydratase
A7E59_RS02620	COG1760	l-serine dehydratase
A7E59_RS02635	COG0778	Nitroreductase
A7E59_RS02645	COG1132	(ABC) transporter
A7E59_RS02650	COG1132	(ABC) transporter
A7E59_RS02660	COG0803	Belongs to the bacterial solute-binding protein 9 family
A7E59_RS02665	COG1846	Transcriptional regulator
A7E59_RS02670	COG0346	lactoylglutathione lyase activity
A7E59_RS02685	COG3250	beta-galactosidase activity
A7E59_RS02690	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
A7E59_RS02695	COG1131	(ABC) transporter
A7E59_RS02705	COG0586	Pfam SNARE associated Golgi protein
A7E59_RS02710	COG2271	Major facilitator Superfamily
A7E59_RS02720	COG3527	Alpha-acetolactate decarboxylase
A7E59_RS02730	COG4876	unkown
A7E59_RS02735	COG0523	cobalamin synthesis protein
A7E59_RS02740	COG2357	RelA SpoT domain protein
A7E59_RS02755	COG2808	Putative FMN-binding domain
A7E59_RS02760	COG1802	Transcriptional regulator
A7E59_RS02765	COG1070	Carbohydrate kinase
A7E59_RS02770	COG2610	gluconate transmembrane transporter activity
A7E59_RS02780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A7E59_RS02785	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A7E59_RS02810	COG4619	ABC transporter
A7E59_RS02815	COG0390	transport system, permease component
A7E59_RS02820	COG2814	Major facilitator Superfamily
A7E59_RS02825	COG2272	Belongs to the type-B carboxylesterase lipase family
A7E59_RS02830	COG0531	amino acid
A7E59_RS02835	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
A7E59_RS02845	COG1174	glycine betaine transport
A7E59_RS02855	COG1174	glycine betaine transport
A7E59_RS02865	COG1309	transcriptional regulator
A7E59_RS02880	COG1346	cytolysis
A7E59_RS02890	COG3279	Response regulator of the LytR AlgR family
A7E59_RS02895	COG3275	phosphorelay sensor kinase activity
A7E59_RS02910	COG0531	amino acid
A7E59_RS02920	COG1113	amino acid transport
A7E59_RS02930	COG2814	Major facilitator Superfamily
A7E59_RS02940	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A7E59_RS02945	COG0741	lytic transglycosylase activity
A7E59_RS02950	COG0588	phosphoglycerate mutase activity
A7E59_RS02960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7E59_RS02965	COG0765	amino acid transport
A7E59_RS02970	COG1126	abc transporter atp-binding protein
A7E59_RS02995	COG2353	YceI-like domain
A7E59_RS03010	COG2116	formate transmembrane transporter activity
A7E59_RS03025	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A7E59_RS03030	COG2146	nitrite reductase [NAD(P)H] activity
A7E59_RS03035	COG1648	precorrin-2 dehydrogenase activity
A7E59_RS03035	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A7E59_RS03040	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
A7E59_RS03045	COG1140	nitrate reductase beta subunit
A7E59_RS03055	COG2181	nitrate reductase activity
A7E59_RS03065	COG4585	Histidine kinase
A7E59_RS03070	COG2197	response regulator
A7E59_RS03075	COG2223	nitrite transmembrane transporter activity
A7E59_RS03080	COG0772	Belongs to the SEDS family
A7E59_RS03085	COG0772	Belongs to the SEDS family
A7E59_RS03090	COG3425	synthase
A7E59_RS03120	COG0697	spore germination
A7E59_RS03155	COG0492	ferredoxin-NADP+ reductase activity
A7E59_RS03160	COG2814	Major facilitator Superfamily
A7E59_RS03165	COG0604	alcohol dehydrogenase
A7E59_RS03175	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A7E59_RS03180	COG1620	l-lactate permease
A7E59_RS03185	COG0438	transferase activity, transferring glycosyl groups
A7E59_RS03195	COG5002	protein histidine kinase activity
A7E59_RS03195	COG3850	Histidine kinase
A7E59_RS03200	COG0745	RESPONSE REGULATOR receiver
A7E59_RS03205	COG0577	efflux transmembrane transporter activity
A7E59_RS03210	COG1136	(ABC) transporter
A7E59_RS03225	COG4640	response to antibiotic
A7E59_RS03230	COG2814	Major facilitator Superfamily
A7E59_RS03235	COG2409	Drug exporters of the RND superfamily
A7E59_RS03235	COG1033	growth of symbiont in host cell
A7E59_RS03245	COG1566	PFAM secretion protein HlyD family protein
A7E59_RS03250	COG2814	Major facilitator Superfamily
A7E59_RS03270	COG0598	Magnesium transport protein CorA
A7E59_RS03275	COG1304	FMN binding
A7E59_RS03285	COG1328	CTP reductase activity
A7E59_RS03290	COG0602	queuosine metabolic process
A7E59_RS03295	COG2094	Belongs to the DNA glycosylase MPG family
A7E59_RS03300	COG3152	Membrane
A7E59_RS03325	COG4152	abc transporter atp-binding protein
A7E59_RS03330	COG1668	transmembrane transport
A7E59_RS03335	COG1742	UPF0060 membrane protein
A7E59_RS03340	COG2017	converts alpha-aldose to the beta-anomer
A7E59_RS03345	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A7E59_RS03350	COG1266	CAAX protease self-immunity
A7E59_RS03355	COG0010	Belongs to the arginase family
A7E59_RS03360	COG0583	DNA-binding transcription factor activity
A7E59_RS03365	COG3314	Sporulation integral membrane protein YlbJ
A7E59_RS03370	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A7E59_RS03375	COG1228	amidohydrolase
A7E59_RS03380	COG0659	secondary active sulfate transmembrane transporter activity
A7E59_RS03385	COG1473	amidohydrolase
A7E59_RS03390	COG1028	Short-chain dehydrogenase reductase Sdr
A7E59_RS03395	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A7E59_RS03410	COG2271	Major facilitator Superfamily
A7E59_RS03425	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A7E59_RS03450	COG1113	amino acid transport
A7E59_RS03455	COG1737	Transcriptional regulator
A7E59_RS03490	COG3383	formate dehydrogenase (NAD+) activity
A7E59_RS03515	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A7E59_RS03520	COG2076	Multidrug Resistance protein
A7E59_RS03525	COG2076	Multidrug Resistance protein
A7E59_RS03540	COG1757	Na H antiporter
A7E59_RS03550	COG3942	CHAP domain
A7E59_RS03570	COG0829	nickel cation binding
A7E59_RS03585	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
A7E59_RS03590	COG0804	urea catabolic process
A7E59_RS03595	COG0832	Belongs to the urease beta subunit family
A7E59_RS03600	COG0831	urea catabolic process
A7E59_RS03610	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A7E59_RS03615	COG1960	acyl-CoA dehydrogenase activity
A7E59_RS03620	COG1957	nucleoside hydrolase
A7E59_RS03625	COG1268	BioY protein
A7E59_RS03635	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A7E59_RS03640	COG1609	Transcriptional regulator
A7E59_RS03645	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A7E59_RS03650	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A7E59_RS03655	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
A7E59_RS03660	COG0725	ABC transporter, periplasmic molybdate-binding protein
A7E59_RS03665	COG4149	molybdate abc transporter
A7E59_RS03670	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A7E59_RS03675	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A7E59_RS03680	COG0521	Mo-molybdopterin cofactor biosynthetic process
A7E59_RS03685	COG0315	cyclic pyranopterin monophosphate synthase activity
A7E59_RS03700	COG0314	molybdopterin synthase activity
A7E59_RS03710	COG0746	molybdenum cofactor guanylyltransferase activity
A7E59_RS03715	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A7E59_RS03725	COG2814	Major facilitator Superfamily
A7E59_RS03745	COG2348	transferase activity, transferring amino-acyl groups
A7E59_RS03750	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A7E59_RS03785	COG4975	Glucose uptake
A7E59_RS03795	COG0551	DNA topoisomerase type I activity
A7E59_RS03795	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A7E59_RS03800	COG2252	PERMEase
A7E59_RS03815	COG0051	transcription antitermination factor activity, RNA binding
A7E59_RS03820	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A7E59_RS03825	COG0088	Forms part of the polypeptide exit tunnel
A7E59_RS03830	COG0089	rRNA binding
A7E59_RS03835	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A7E59_RS03840	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A7E59_RS03845	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A7E59_RS03850	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A7E59_RS03855	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A7E59_RS03865	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A7E59_RS03870	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A7E59_RS03875	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A7E59_RS03880	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A7E59_RS03885	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A7E59_RS03890	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A7E59_RS03895	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A7E59_RS03900	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A7E59_RS03905	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A7E59_RS03910	COG1841	ribosomal large subunit assembly
A7E59_RS03915	COG0200	Binds to the 23S rRNA
A7E59_RS03920	COG0201	protein transport
A7E59_RS03925	COG0563	adenylate kinase activity
A7E59_RS03935	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A7E59_RS03940	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A7E59_RS03945	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A7E59_RS03950	COG0202	RNA polymerase activity
A7E59_RS03955	COG0203	ribosomal protein L17
A7E59_RS03975	COG0101	tRNA pseudouridine synthase activity
A7E59_RS03980	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A7E59_RS03985	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A7E59_RS03990	COG1846	Transcriptional regulator
A7E59_RS03995	COG2814	Major facilitator Superfamily
A7E59_RS04000	COG1335	isochorismatase
A7E59_RS04020	COG2318	DinB family
A7E59_RS04025	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A7E59_RS04025	COG0574	Belongs to the PEP-utilizing enzyme family
A7E59_RS04030	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A7E59_RS04035	COG2130	NADP-dependent
A7E59_RS04045	COG2130	NADP-dependent
A7E59_RS04050	COG0604	alcohol dehydrogenase
A7E59_RS04070	COG1302	Protein conserved in bacteria
A7E59_RS04085	COG4264	IucA IucC family
A7E59_RS04090	COG3457	Alanine racemase
A7E59_RS04095	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
A7E59_RS04100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7E59_RS04105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7E59_RS04110	COG3314	Sporulation integral membrane protein YlbJ
A7E59_RS04115	COG2329	Antibiotic biosynthesis monooxygenase
A7E59_RS04130	COG1988	membrane-bound metal-dependent
A7E59_RS04135	COG4284	Utp--glucose-1-phosphate uridylyltransferase
A7E59_RS04140	COG1272	protein, Hemolysin III
A7E59_RS04155	COG2814	Major facilitator Superfamily
A7E59_RS04160	COG0489	protein tyrosine kinase activity
A7E59_RS04210	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A7E59_RS04215	COG4856	YbbR-like protein
A7E59_RS04220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A7E59_RS04230	COG3711	transcriptional antiterminator
A7E59_RS04235	COG3711	transcriptional antiterminator
A7E59_RS04275	COG0640	Transcriptional regulator
A7E59_RS04280	COG0702	epimerase
A7E59_RS04285	COG2186	Transcriptional regulator
A7E59_RS04290	COG1482	cell wall glycoprotein biosynthetic process
A7E59_RS04310	COG0783	Belongs to the Dps family
A7E59_RS04315	COG1876	peptidase activity
A7E59_RS04320	COG0813	purine-nucleoside phosphorylase activity
A7E59_RS04325	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A7E59_RS04335	COG1854	S-ribosylhomocysteine lyase activity
A7E59_RS04355	COG5146	pantothenate kinase activity
A7E59_RS04365	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A7E59_RS04370	COG3343	RNA polymerase activity
A7E59_RS04375	COG0504	CTP synthase activity
A7E59_RS04385	COG0191	fructose-bisphosphate aldolase activity
A7E59_RS04390	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A7E59_RS04400	COG1012	belongs to the aldehyde dehydrogenase family
A7E59_RS04405	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A7E59_RS04410	COG0254	rRNA binding
A7E59_RS04420	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A7E59_RS04425	COG2890	protein-(glutamine-N5) methyltransferase activity
A7E59_RS04430	COG0009	L-threonylcarbamoyladenylate synthase
A7E59_RS04435	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A7E59_RS04440	COG4475	Protein of unknown function (DUF436)
A7E59_RS04445	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A7E59_RS04450	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A7E59_RS04455	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A7E59_RS04465	COG0356	it plays a direct role in the translocation of protons across the membrane
A7E59_RS04470	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A7E59_RS04475	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A7E59_RS04480	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A7E59_RS04490	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A7E59_RS04495	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A7E59_RS04500	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A7E59_RS04510	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A7E59_RS04515	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A7E59_RS04525	COG0629	single-stranded DNA binding
A7E59_RS04530	COG1388	LysM domain
A7E59_RS04535	COG1388	LysM domain
A7E59_RS04540	COG1388	LysM domain
A7E59_RS04545	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A7E59_RS04555	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
A7E59_RS04560	COG0352	thiamine-phosphate diphosphorylase activity
A7E59_RS04565	COG0706	membrane insertase activity
A7E59_RS04575	COG1418	mRNA catabolic process
A7E59_RS04580	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A7E59_RS04585	COG1937	Protein conserved in bacteria
A7E59_RS04600	COG2217	Heavy metal translocating P-type atpase
A7E59_RS04610	COG0772	Belongs to the SEDS family
A7E59_RS04615	COG1181	Belongs to the D-alanine--D-alanine ligase family
A7E59_RS04620	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A7E59_RS04640	COG3402	PFAM membrane-flanked domain
A7E59_RS04645	COG0736	holo-[acyl-carrier-protein] synthase activity
A7E59_RS04650	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A7E59_RS04665	COG2208	phosphoserine phosphatase activity
A7E59_RS04680	COG1191	sigma factor activity
A7E59_RS04685	COG2183	response to ionizing radiation
A7E59_RS04690	COG3091	SprT-like family
A7E59_RS04725	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A7E59_RS04730	COG0473	3-isopropylmalate dehydrogenase activity
A7E59_RS04735	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A7E59_RS04740	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A7E59_RS04745	COG0440	acetolactate synthase activity
A7E59_RS04750	COG0028	Belongs to the TPP enzyme family
A7E59_RS04755	COG0129	dihydroxy-acid dehydratase activity
A7E59_RS04760	COG0802	atpase or kinase
A7E59_RS04765	COG1214	PFAM Peptidase M22, glycoprotease
A7E59_RS04770	COG0456	acetyltransferase
A7E59_RS04775	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A7E59_RS04780	COG0488	(ABC) transporter
A7E59_RS04785	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
A7E59_RS04790	COG0425	Belongs to the sulfur carrier protein TusA family
A7E59_RS04795	COG2391	methyltransferase activity
A7E59_RS04800	COG1621	beta-fructofuranosidase activity
A7E59_RS04805	COG3279	Response regulator of the LytR AlgR family
A7E59_RS04840	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A7E59_RS04845	COG0459	protein refolding
A7E59_RS04885	COG1725	Transcriptional regulator
A7E59_RS04890	COG1131	(ABC) transporter
A7E59_RS04900	COG1131	(ABC) transporter
A7E59_RS04945	COG2706	6-phosphogluconolactonase activity
A7E59_RS04950	COG0471	metal ion transport
A7E59_RS04960	COG1335	isochorismatase
A7E59_RS04965	COG1227	inorganic diphosphatase activity
A7E59_RS04970	COG1012	belongs to the aldehyde dehydrogenase family
A7E59_RS04980	COG0077	Prephenate dehydratase
A7E59_RS04990	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A7E59_RS04995	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A7E59_RS05000	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
A7E59_RS05010	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A7E59_RS05015	COG4496	protein, YerC YecD
A7E59_RS05020	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
A7E59_RS05030	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A7E59_RS05035	COG4851	CamS sex pheromone cAM373 precursor
A7E59_RS05045	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A7E59_RS05050	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A7E59_RS05055	COG0154	amidase activity
A7E59_RS05060	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A7E59_RS05065	COG1597	lipid kinase activity
A7E59_RS05080	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A7E59_RS05100	COG4129	membrane
A7E59_RS05125	COG2197	response regulator
A7E59_RS05130	COG0288	reversible hydration of carbon dioxide
A7E59_RS05135	COG1295	ribonuclease BN
A7E59_RS05150	COG4840	Belongs to the UPF0435 family
A7E59_RS05155	COG2309	aminopeptidase activity
A7E59_RS05160	COG1607	acyl-coa hydrolase
A7E59_RS05165	COG0535	radical SAM domain protein
A7E59_RS05180	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A7E59_RS05185	COG2137	regulation of response to DNA damage stimulus
A7E59_RS05195	COG1388	LysM domain
A7E59_RS05195	COG1134	teichoic acid transport
A7E59_RS05205	COG1988	membrane-bound metal-dependent
A7E59_RS05215	COG3557	Belongs to the UPF0374 family
A7E59_RS05225	COG4129	membrane
A7E59_RS05230	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A7E59_RS05235	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A7E59_RS05245	COG0735	belongs to the Fur family
A7E59_RS05400	COG0765	amino acid transport
A7E59_RS05405	COG1126	abc transporter atp-binding protein
A7E59_RS05410	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A7E59_RS05420	COG0363	glucosamine-6-phosphate deaminase activity
A7E59_RS05430	COG0114	fumarate hydratase activity
A7E59_RS05435	COG0564	pseudouridine synthase activity
A7E59_RS05440	COG4585	Histidine kinase
A7E59_RS05440	COG2203	Gaf domain
A7E59_RS05445	COG2197	response regulator
A7E59_RS05450	COG1301	dicarboxylic acid transport
A7E59_RS05460	COG4399	Belongs to the UPF0754 family
A7E59_RS05465	COG3679	Belongs to the UPF0342 family
A7E59_RS05470	COG0420	3'-5' exonuclease activity
A7E59_RS05480	COG3481	metal-dependent phosphohydrolase, HD sub domain
A7E59_RS05485	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A7E59_RS05500	COG0537	adenosine 5'-monophosphoramidase activity
A7E59_RS05505	COG1131	(ABC) transporter
A7E59_RS05510	COG4473	ABC transporter
A7E59_RS05520	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A7E59_RS05525	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A7E59_RS05530	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
A7E59_RS05540	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A7E59_RS05545	COG0157	Belongs to the NadC ModD family
A7E59_RS05550	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A7E59_RS05570	COG1827	regulation of RNA biosynthetic process
A7E59_RS05575	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A7E59_RS05645	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A7E59_RS05655	COG1506	peptidase
A7E59_RS05660	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A7E59_RS05665	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A7E59_RS05680	COG0656	L-ascorbic acid biosynthetic process
A7E59_RS05685	COG1397	ADP-ribosylglycohydrolase
A7E59_RS05690	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A7E59_RS05705	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A7E59_RS05725	COG4193	domain, Protein
A7E59_RS05725	COG3266	domain, Protein
A7E59_RS05725	COG5632	N-Acetylmuramoyl-L-alanine amidase
A7E59_RS05735	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A7E59_RS05735	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A7E59_RS05740	COG0307	riboflavin synthase, alpha
A7E59_RS05745	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A7E59_RS05745	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A7E59_RS05750	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A7E59_RS05755	COG0506	proline dehydrogenase activity
A7E59_RS05760	COG2267	carboxylic ester hydrolase activity
A7E59_RS05765	COG0039	L-malate dehydrogenase activity
A7E59_RS05770	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A7E59_RS05775	COG1242	4 iron, 4 sulfur cluster binding
A7E59_RS05780	COG2814	Major facilitator Superfamily
A7E59_RS05795	COG2081	HI0933 family
A7E59_RS05800	COG2244	polysaccharide biosynthetic process
A7E59_RS05805	COG1187	pseudouridine synthase activity
A7E59_RS05815	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A7E59_RS05825	COG0510	thiamine kinase activity
A7E59_RS05830	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A7E59_RS05835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A7E59_RS05840	COG5584	Small secreted protein
A7E59_RS05845	COG1363	Peptidase, m42
A7E59_RS05850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A7E59_RS05855	COG4848	Belongs to the UPF0354 family
A7E59_RS05860	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A7E59_RS05865	COG1674	ftsk spoiiie
A7E59_RS05870	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A7E59_RS05875	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
A7E59_RS05885	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A7E59_RS05885	COG1605	Chorismate mutase
A7E59_RS05890	COG1609	Transcriptional regulator
A7E59_RS05900	COG0454	-acetyltransferase
A7E59_RS05905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A7E59_RS05910	COG2759	Belongs to the formate--tetrahydrofolate ligase family
A7E59_RS05920	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A7E59_RS05925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A7E59_RS05930	COG0204	Acyl-transferase
A7E59_RS05935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7E59_RS05935	COG1263	PTS System
A7E59_RS05945	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A7E59_RS05950	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A7E59_RS05955	COG1764	response to oxidative stress
A7E59_RS05960	COG0584	glycerophosphoryl diester phosphodiesterase
A7E59_RS05965	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A7E59_RS05970	COG1956	GAF domain-containing protein
A7E59_RS05975	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
A7E59_RS05980	COG1104	cysteine desulfurase activity
A7E59_RS05985	COG0301	tRNA thio-modification
A7E59_RS05995	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A7E59_RS06000	COG0827	DNA restriction-modification system
A7E59_RS06005	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A7E59_RS06010	COG0589	response to stress
A7E59_RS06015	COG0686	Belongs to the AlaDH PNT family
A7E59_RS06020	COG0006	proline dipeptidase activity
A7E59_RS06025	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A7E59_RS06035	COG4109	DRTGG domain
A7E59_RS06040	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A7E59_RS06050	COG0281	malic enzyme
A7E59_RS06055	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A7E59_RS06060	COG0825	malonyl-CoA metabolic process
A7E59_RS06065	COG0205	6-phosphofructokinase activity
A7E59_RS06070	COG0469	pyruvate kinase activity
A7E59_RS06075	COG1113	amino acid transport
A7E59_RS06080	COG0372	Belongs to the citrate synthase family
A7E59_RS06085	COG0538	isocitrate dehydrogenase activity
A7E59_RS06090	COG0745	RESPONSE REGULATOR receiver
A7E59_RS06095	COG5002	protein histidine kinase activity
A7E59_RS06100	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A7E59_RS06100	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A7E59_RS06110	COG0237	dephospho-CoA kinase activity
A7E59_RS06120	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A7E59_RS06125	COG3611	Membrane attachment protein
A7E59_RS06130	COG1484	DNA-dependent DNA replication
A7E59_RS06135	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A7E59_RS06140	COG0833	amino acid
A7E59_RS06145	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A7E59_RS06150	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A7E59_RS06155	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A7E59_RS06160	COG4112	unkown
A7E59_RS06170	COG0544	peptidyl-prolyl cis-trans isomerase activity
A7E59_RS06175	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A7E59_RS06180	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A7E59_RS06185	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A7E59_RS06190	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A7E59_RS06195	COG0181	hydroxymethylbilane synthase activity
A7E59_RS06210	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A7E59_RS06215	COG3180	Ammonia monooxygenase
A7E59_RS06220	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
A7E59_RS06230	COG0525	valine-tRNA ligase activity
A7E59_RS06235	COG0285	dihydrofolate synthase activity
A7E59_RS06245	COG2003	Belongs to the UPF0758 family
A7E59_RS06265	COG1792	Involved in formation and maintenance of cell shape
A7E59_RS06275	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A7E59_RS06280	COG2868	ribosomal protein
A7E59_RS06285	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A7E59_RS06290	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A7E59_RS06295	COG4492	Belongs to the UPF0735 family
A7E59_RS06300	COG0632	four-way junction helicase activity
A7E59_RS06305	COG2255	four-way junction helicase activity
A7E59_RS06310	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A7E59_RS06315	COG0343	queuine tRNA-ribosyltransferase activity
A7E59_RS06320	COG1862	Preprotein translocase
A7E59_RS06325	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A7E59_RS06325	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A7E59_RS06330	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A7E59_RS06330	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A7E59_RS06335	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A7E59_RS06345	COG1490	D-aminoacyl-tRNA deacylase activity
A7E59_RS06350	COG0860	N-Acetylmuramoyl-L-alanine amidase
A7E59_RS06355	COG0124	histidyl-tRNA synthetase
A7E59_RS06360	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A7E59_RS06370	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A7E59_RS06375	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A7E59_RS06380	COG1959	2 iron, 2 sulfur cluster binding
A7E59_RS06385	COG3237	CsbD-like
A7E59_RS06390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7E59_RS06395	COG1104	cysteine desulfurase activity
A7E59_RS06400	COG0482	sulfurtransferase activity
A7E59_RS06410	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A7E59_RS06415	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A7E59_RS06420	COG4472	Bacterial protein of unknown function (DUF965)
A7E59_RS06425	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A7E59_RS06430	COG3906	Belongs to the UPF0473 family
A7E59_RS06435	COG4122	O-methyltransferase activity
A7E59_RS06440	COG0826	peptidase U32
A7E59_RS06445	COG0826	peptidase U32
A7E59_RS06450	COG0572	uridine kinase
A7E59_RS06455	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A7E59_RS06460	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A7E59_RS06465	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
A7E59_RS06470	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A7E59_RS06475	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A7E59_RS06480	COG1534	Rna-binding protein
A7E59_RS06485	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A7E59_RS06490	COG1713	HD superfamily hydrolase involved in NAD metabolism
A7E59_RS06495	COG0799	negative regulation of ribosome biogenesis
A7E59_RS06500	COG2226	methyltransferase
A7E59_RS06505	COG1596	polysaccharide export
A7E59_RS06505	COG1555	photosystem II stabilization
A7E59_RS06510	COG2131	deaminase
A7E59_RS06515	COG2333	competence protein COMEC
A7E59_RS06515	COG0658	competence protein
A7E59_RS06520	COG1466	dna polymerase III delta subunit
A7E59_RS06525	COG0268	Binds directly to 16S ribosomal RNA
A7E59_RS06530	COG0481	GTPase activity
A7E59_RS06535	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A7E59_RS06540	COG1420	regulation of RNA biosynthetic process
A7E59_RS06545	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A7E59_RS06550	COG0443	Heat shock 70 kDa protein
A7E59_RS06555	COG0484	heat shock protein binding
A7E59_RS06560	COG2264	protein methyltransferase activity
A7E59_RS06565	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A7E59_RS06570	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A7E59_RS06585	COG4864	UPF0365 protein
A7E59_RS06595	COG1702	phosphate starvation-inducible protein PhoH
A7E59_RS06600	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A7E59_RS06605	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A7E59_RS06615	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A7E59_RS06620	COG1381	Involved in DNA repair and RecF pathway recombination
A7E59_RS06625	COG0423	glycine-tRNA ligase activity
A7E59_RS06630	COG0517	IMP dehydrogenase activity
A7E59_RS06635	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A7E59_RS06645	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A7E59_RS06650	COG2384	SAM-dependent methyltransferase
A7E59_RS06660	COG0513	Belongs to the DEAD box helicase family
A7E59_RS06665	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A7E59_RS06670	COG1121	(ABC) transporter
A7E59_RS06675	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A7E59_RS06690	COG0768	penicillin binding
A7E59_RS06695	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A7E59_RS06705	COG4483	Protein conserved in bacteria
A7E59_RS06710	COG1940	carbohydrate kinase activity
A7E59_RS06715	COG0011	TIGRFAM Protein of
A7E59_RS06720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A7E59_RS06785	COG1459	type II secretion system
A7E59_RS06815	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A7E59_RS06820	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A7E59_RS06825	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A7E59_RS06830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A7E59_RS06835	COG0095	Lipoate-protein ligase
A7E59_RS06850	COG0006	proline dipeptidase activity
A7E59_RS06855	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A7E59_RS06860	COG0511	ligase activity, forming carbon-carbon bonds
A7E59_RS06865	COG0439	Biotin carboxylase
A7E59_RS06875	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A7E59_RS06880	COG1570	exodeoxyribonuclease VII activity
A7E59_RS06885	COG1722	exodeoxyribonuclease VII activity
A7E59_RS06895	COG1438	arginine binding
A7E59_RS06900	COG0497	DNA recombination
A7E59_RS06905	COG0280	phosphate acetyltransferase
A7E59_RS06910	COG3426	butyrate kinase activity
A7E59_RS06915	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A7E59_RS06920	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A7E59_RS06925	COG0022	dehydrogenase e1 component
A7E59_RS06930	COG0508	dehydrogenase complex catalyzes the overall conversion of
A7E59_RS06940	COG4129	membrane
A7E59_RS06945	COG2195	Cleaves the N-terminal amino acid of tripeptides
A7E59_RS06950	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A7E59_RS06960	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A7E59_RS06965	COG1234	tRNA 3'-trailer cleavage
A7E59_RS06970	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A7E59_RS06975	COG1028	Short-chain dehydrogenase reductase Sdr
A7E59_RS06980	COG0667	Aldo Keto reductase
A7E59_RS06985	COG0494	nUDIX hydrolase
A7E59_RS06990	COG0735	belongs to the Fur family
A7E59_RS06995	COG4974	Belongs to the 'phage' integrase family
A7E59_RS07005	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A7E59_RS07010	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A7E59_RS07015	COG1187	pseudouridine synthase activity
A7E59_RS07020	COG0745	RESPONSE REGULATOR receiver
A7E59_RS07035	COG1141	Ferredoxin
A7E59_RS07045	COG0514	ATP-dependent DNA helicase (RecQ)
A7E59_RS07050	COG1388	LysM domain
A7E59_RS07050	COG1388	LysM domain
A7E59_RS07055	COG0492	ferredoxin-NADP+ reductase activity
A7E59_RS07065	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A7E59_RS07070	COG0539	negative regulation of cytoplasmic translation
A7E59_RS07075	COG1160	GTP binding
A7E59_RS07080	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A7E59_RS07095	COG2226	methyltransferase
A7E59_RS07100	COG0142	geranyltranstransferase activity
A7E59_RS07105	COG0105	UTP biosynthetic process
A7E59_RS07110	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A7E59_RS07115	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A7E59_RS07120	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A7E59_RS07125	COG0457	Tetratricopeptide repeat
A7E59_RS07130	COG5582	Belongs to the UPF0302 family
A7E59_RS07135	COG4347	Protein of unknown function (DUF1405)
A7E59_RS07140	COG2738	Putative neutral zinc metallopeptidase
A7E59_RS07145	COG1694	Mazg nucleotide pyrophosphohydrolase
A7E59_RS07150	COG0438	transferase activity, transferring glycosyl groups
A7E59_RS07155	COG0617	tRNA 3'-terminal CCA addition
A7E59_RS07165	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A7E59_RS07165	COG1199	ATP-dependent helicase activity
A7E59_RS07170	COG0017	Asparaginyl-tRNA synthetase
A7E59_RS07175	COG3935	DnaD domain protein
A7E59_RS07180	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A7E59_RS07190	COG4499	WXG100 protein secretion system (Wss), protein YukC
A7E59_RS07190	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A7E59_RS07195	COG3331	DNA recombination
A7E59_RS07205	COG4474	Belongs to the UPF0398 family
A7E59_RS07210	COG3599	regulation of cell shape
A7E59_RS07220	COG0116	Belongs to the methyltransferase superfamily
A7E59_RS07225	COG2962	Rard protein
A7E59_RS07230	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A7E59_RS07235	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A7E59_RS07240	COG0328	RNA-DNA hybrid ribonuclease activity
A7E59_RS07245	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A7E59_RS07255	COG1413	lyase activity
A7E59_RS07285	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A7E59_RS07290	COG2190	(PTS) system
A7E59_RS07295	COG4479	Belongs to the UPF0346 family
A7E59_RS07300	COG0793	Belongs to the peptidase S41A family
A7E59_RS07310	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A7E59_RS07315	COG0671	phosphoesterase, PA-phosphatase related
A7E59_RS07320	COG0745	RESPONSE REGULATOR receiver
A7E59_RS07325	COG5002	protein histidine kinase activity
A7E59_RS07330	COG0567	Dehydrogenase, E1 component
A7E59_RS07355	COG0714	Associated with various cellular activities
A7E59_RS07360	COG4548	von Willebrand factor, type A
A7E59_RS07365	COG1114	Component of the transport system for branched-chain amino acids
A7E59_RS07370	COG1597	lipid kinase activity
A7E59_RS07375	COG3853	Toxic anion resistance protein (TelA)
A7E59_RS07410	COG1473	amidohydrolase
A7E59_RS07415	COG2171	N-acyltransferase activity
A7E59_RS07420	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A7E59_RS07425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A7E59_RS07430	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A7E59_RS07435	COG0527	aspartate kinase activity
A7E59_RS07440	COG0488	(ABC) transporter
A7E59_RS07445	COG2996	Protein conserved in bacteria
A7E59_RS07450	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A7E59_RS07455	COG0573	inorganic phosphate transmembrane transporter activity
A7E59_RS07460	COG0581	inorganic phosphate transmembrane transporter activity
A7E59_RS07465	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A7E59_RS07470	COG0704	Plays a role in the regulation of phosphate uptake
A7E59_RS07475	COG1164	Oligoendopeptidase f
A7E59_RS07515	COG2348	transferase activity, transferring amino-acyl groups
A7E59_RS07520	COG2348	transferase activity, transferring amino-acyl groups
A7E59_RS07525	COG0159	tryptophan synthase activity
A7E59_RS07535	COG0135	phosphoribosylanthranilate isomerase activity
A7E59_RS07540	COG0134	indole-3-glycerol-phosphate synthase activity
A7E59_RS07545	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A7E59_RS07555	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A7E59_RS07560	COG1363	Peptidase, m42
A7E59_RS07565	COG0287	Prephenate dehydrogenase
A7E59_RS07605	COG0628	permease
A7E59_RS07610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7E59_RS07610	COG2190	(PTS) system
A7E59_RS07610	COG1263	PTS System
A7E59_RS07615	COG2190	(PTS) system
A7E59_RS07615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7E59_RS07615	COG1263	PTS System
A7E59_RS07620	COG3711	transcriptional antiterminator
A7E59_RS07625	COG1115	amino acid carrier protein
A7E59_RS07630	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A7E59_RS07635	COG0187	DNA topoisomerase II activity
A7E59_RS07640	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A7E59_RS07645	COG4841	protein insertion into membrane
A7E59_RS07650	COG0824	Thioesterase
A7E59_RS07655	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A7E59_RS07660	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A7E59_RS07665	COG1970	mechanosensitive ion channel activity
A7E59_RS07675	COG0420	3'-5' exonuclease activity
A7E59_RS07680	COG4846	Membrane protein involved in cytochrome C biogenesis
A7E59_RS07685	COG3763	UPF0154 protein
A7E59_RS07690	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A7E59_RS07695	COG4224	UPF0291 protein
A7E59_RS07705	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A7E59_RS07710	COG2340	Cysteine-rich secretory protein family
A7E59_RS07715	COG0516	GMP reductase activity
A7E59_RS07720	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A7E59_RS07730	COG0833	amino acid
A7E59_RS07740	COG0561	phosphatase activity
A7E59_RS07745	COG0083	homoserine kinase activity
A7E59_RS07750	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A7E59_RS07755	COG0460	homoserine dehydrogenase
A7E59_RS07760	COG0527	aspartate kinase activity
A7E59_RS07785	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
A7E59_RS07790	COG1525	nuclease
A7E59_RS07800	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A7E59_RS07810	COG0789	Transcriptional regulator
A7E59_RS07820	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
A7E59_RS07825	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A7E59_RS07835	COG1923	regulation of RNA biosynthetic process
A7E59_RS07840	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A7E59_RS07845	COG2267	carboxylic ester hydrolase activity
A7E59_RS07850	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A7E59_RS07855	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A7E59_RS07860	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A7E59_RS07870	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A7E59_RS07875	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A7E59_RS07880	COG0584	glycerophosphoryl diester phosphodiesterase
A7E59_RS07890	COG4550	Control of competence regulator ComK, YlbF/YmcA
A7E59_RS07895	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A7E59_RS07900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7E59_RS07905	COG0601	transmembrane transport
A7E59_RS07910	COG4608	Belongs to the ABC transporter superfamily
A7E59_RS07935	COG1013	pyruvate-flavodoxin oxidoreductase activity
A7E59_RS07940	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A7E59_RS07940	COG0674	pyruvate-flavodoxin oxidoreductase activity
A7E59_RS07945	COG1692	metallophosphoesterase
A7E59_RS07955	COG0583	DNA-binding transcription factor activity
A7E59_RS07965	COG1418	mRNA catabolic process
A7E59_RS07970	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A7E59_RS07975	COG1546	Belongs to the CinA family
A7E59_RS07975	COG1058	Belongs to the CinA family
A7E59_RS07995	COG0300	oxidoreductase activity
A7E59_RS08000	COG0612	Peptidase, M16
A7E59_RS08005	COG0612	Peptidase, M16
A7E59_RS08010	COG2188	Transcriptional regulator
A7E59_RS08020	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A7E59_RS08025	COG1185	polyribonucleotide nucleotidyltransferase activity
A7E59_RS08030	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A7E59_RS08035	COG0196	riboflavin kinase activity
A7E59_RS08040	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A7E59_RS08045	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A7E59_RS08055	COG0584	glycerophosphoryl diester phosphodiesterase
A7E59_RS08070	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A7E59_RS08075	COG1358	cellular component organization or biogenesis
A7E59_RS08080	COG2740	Nucleic-acid-binding protein implicated in transcription termination
A7E59_RS08085	COG0195	Participates in both transcription termination and antitermination
A7E59_RS08090	COG0779	Required for maturation of 30S ribosomal subunits
A7E59_RS08095	COG2176	DNA-directed DNA polymerase activity
A7E59_RS08100	COG0442	prolyl-tRNA aminoacylation
A7E59_RS08110	COG4589	Belongs to the CDS family
A7E59_RS08120	COG0233	cytoplasmic translational termination
A7E59_RS08125	COG0528	UMP kinase activity
A7E59_RS08130	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A7E59_RS08135	COG0052	Belongs to the universal ribosomal protein uS2 family
A7E59_RS08140	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
A7E59_RS08145	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A7E59_RS08150	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A7E59_RS08155	COG4974	Belongs to the 'phage' integrase family
A7E59_RS08160	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
A7E59_RS08165	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A7E59_RS08175	COG0045	succinate-CoA ligase (ADP-forming) activity
A7E59_RS08180	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A7E59_RS08205	COG4149	molybdate abc transporter
A7E59_RS08215	COG1349	DNA-binding transcription factor activity
A7E59_RS08230	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
A7E59_RS08235	COG4485	Bacterial membrane protein, YfhO
A7E59_RS08255	COG0335	large ribosomal subunit rRNA binding
A7E59_RS08260	COG0336	Belongs to the RNA methyltransferase TrmD family
A7E59_RS08265	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A7E59_RS08270	COG0228	four-way junction DNA binding
A7E59_RS08280	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A7E59_RS08285	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
A7E59_RS08290	COG0552	protein localization to endoplasmic reticulum
A7E59_RS08295	COG1196	nuclear chromosome segregation
A7E59_RS08300	COG0571	ribonuclease III activity
A7E59_RS08305	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A7E59_RS08320	COG0416	fatty acid biosynthetic process
A7E59_RS08325	COG1349	DNA-binding transcription factor activity
A7E59_RS08335	COG1760	l-serine dehydratase
A7E59_RS08340	COG1760	l-serine dehydratase
A7E59_RS08345	COG1461	Dihydroxyacetone kinase
A7E59_RS08350	COG1302	Protein conserved in bacteria
A7E59_RS08355	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A7E59_RS08370	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A7E59_RS08375	COG1162	GTPase activity
A7E59_RS08385	COG0631	protein serine/threonine phosphatase activity
A7E59_RS08390	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A7E59_RS08395	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A7E59_RS08395	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A7E59_RS08400	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A7E59_RS08425	COG2910	NAD(P)H-binding
A7E59_RS08430	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A7E59_RS08435	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A7E59_RS08445	COG1758	RNA polymerase activity
A7E59_RS08450	COG0194	GDP metabolic process
A7E59_RS08480	COG0284	orotidine-5'-phosphate decarboxylase activity
A7E59_RS08485	COG0167	dihydroorotate dehydrogenase activity
A7E59_RS08490	COG0543	2 iron, 2 sulfur cluster binding
A7E59_RS08495	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A7E59_RS08500	COG0505	Belongs to the CarA family
A7E59_RS08510	COG0540	Belongs to the ATCase OTCase family
A7E59_RS08515	COG2233	PERMEase
A7E59_RS08520	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A7E59_RS08525	COG0564	pseudouridine synthase activity
A7E59_RS08530	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A7E59_RS08535	COG3942	CHAP domain
A7E59_RS08545	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A7E59_RS08550	COG3599	regulation of cell shape
A7E59_RS08560	COG0762	integral membrane protein
A7E59_RS08565	COG1799	cell septum assembly
A7E59_RS08570	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A7E59_RS08575	COG1496	oxidoreductase activity
A7E59_RS08585	COG0849	cell division
A7E59_RS08590	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A7E59_RS08595	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A7E59_RS08600	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A7E59_RS08605	COG0768	penicillin binding
A7E59_RS08610	COG4839	cell division protein FtsL
A7E59_RS08615	COG0275	rRNA processing
A7E59_RS08620	COG2001	Belongs to the MraZ family
A7E59_RS08625	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
A7E59_RS08630	COG0454	-acetyltransferase
A7E59_RS08635	COG1011	Hydrolase
A7E59_RS08695	COG5434	Belongs to the glycosyl hydrolase 28 family
A7E59_RS08715	COG0741	lytic transglycosylase activity
A7E59_RS08830	COG0756	dUTP diphosphatase activity
A7E59_RS08860	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A7E59_RS08990	COG2153	protein acetylation
A7E59_RS09020	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A7E59_RS09035	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A7E59_RS09040	COG1053	succinate dehydrogenase
A7E59_RS09045	COG2009	succinate dehydrogenase
A7E59_RS09050	COG0322	excinuclease ABC activity
A7E59_RS09055	COG3118	belongs to the thioredoxin family
A7E59_RS09060	COG1193	negative regulation of DNA recombination
A7E59_RS09065	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A7E59_RS09065	COG1796	DNA polymerase
A7E59_RS09080	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A7E59_RS09085	COG0072	phenylalanine-tRNA ligase activity
A7E59_RS09085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A7E59_RS09090	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A7E59_RS09095	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A7E59_RS09100	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A7E59_RS09110	COG1323	Belongs to the UPF0348 family
A7E59_RS09120	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A7E59_RS09125	COG0742	ribosomal rna small subunit methyltransferase
A7E59_RS09135	COG4471	UPF0298 protein
A7E59_RS09140	COG0584	glycerophosphoryl diester phosphodiesterase
A7E59_RS09145	COG3679	Belongs to the UPF0342 family
A7E59_RS09160	COG0109	protoheme IX farnesyltransferase activity
A7E59_RS09165	COG1612	heme a metabolic process
A7E59_RS09175	COG0772	Belongs to the SEDS family
A7E59_RS09180	COG4838	Belongs to the UPF0358 family
A7E59_RS09185	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A7E59_RS09195	COG1217	gtp-binding protein TYPA
A7E59_RS09205	COG0483	inositol monophosphate 1-phosphatase activity
A7E59_RS09210	COG4493	Belongs to the UPF0637 family
A7E59_RS09215	COG1914	H( )-stimulated, divalent metal cation uptake system
A7E59_RS09235	COG1177	transmembrane transport
A7E59_RS09240	COG1176	ABC-type spermidine putrescine transport system, permease component I
A7E59_RS09245	COG3842	ATPase activity
A7E59_RS09255	COG4476	Belongs to the UPF0223 family
A7E59_RS09270	COG0022	dehydrogenase e1 component
A7E59_RS09285	COG0242	peptide deformylase activity
A7E59_RS09295	COG5503	Protein of unknown function (DUF1447)
A7E59_RS09305	COG1733	regulation of RNA biosynthetic process
A7E59_RS09310	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
A7E59_RS09320	COG0569	domain protein
A7E59_RS09325	COG1294	oxidase, subunit
A7E59_RS09330	COG1271	oxidase subunit
A7E59_RS09340	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A7E59_RS09355	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A7E59_RS09370	COG1122	ATPase activity
A7E59_RS09375	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A7E59_RS09385	COG0151	Belongs to the GarS family
A7E59_RS09390	COG0138	bifunctional purine biosynthesis protein purh
A7E59_RS09395	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A7E59_RS09400	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A7E59_RS09405	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A7E59_RS09410	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A7E59_RS09425	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A7E59_RS09430	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A7E59_RS09435	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A7E59_RS09440	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A7E59_RS09445	COG1363	Peptidase, m42
A7E59_RS09450	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A7E59_RS09450	COG1017	nitric oxide dioxygenase activity
A7E59_RS09460	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A7E59_RS09470	COG1845	cytochrome c oxidase, subunit III
A7E59_RS09475	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A7E59_RS09485	COG1349	DNA-binding transcription factor activity
A7E59_RS09495	COG0698	ribose 5-phosphate isomerase
A7E59_RS09515	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A7E59_RS09520	COG2723	6-phospho-beta-galactosidase activity
A7E59_RS09525	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A7E59_RS09525	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A7E59_RS09530	COG1447	Phosphotransferase system cellobiose-specific component IIA
A7E59_RS09545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A7E59_RS09550	COG1316	TRANSCRIPTIONal
A7E59_RS09575	COG3594	Acyltransferase
A7E59_RS09580	COG0436	Aminotransferase
A7E59_RS09585	COG1846	Transcriptional regulator
A7E59_RS09590	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A7E59_RS09600	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A7E59_RS09605	COG1169	isochorismate synthase
A7E59_RS09610	COG1575	Belongs to the MenA family. Type 1 subfamily
A7E59_RS09620	COG2314	TM2 domain
A7E59_RS09635	COG4873	Protein conserved in bacteria
A7E59_RS09665	COG3177	Filamentation induced by cAMP protein fic
A7E59_RS09680	COG2267	carboxylic ester hydrolase activity
A7E59_RS09690	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A7E59_RS09695	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A7E59_RS09700	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A7E59_RS09705	COG0131	Imidazoleglycerol-phosphate dehydratase
A7E59_RS09715	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A7E59_RS09720	COG0107	imidazoleglycerol-phosphate synthase activity
A7E59_RS09730	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A7E59_RS09740	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A7E59_RS09745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A7E59_RS09750	COG0861	Integral membrane protein TerC family
A7E59_RS09755	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A7E59_RS09765	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A7E59_RS09770	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A7E59_RS09775	COG2814	Major facilitator Superfamily
A7E59_RS09785	COG2382	esterase
A7E59_RS09790	COG1115	amino acid carrier protein
A7E59_RS09795	COG0628	permease
A7E59_RS09800	COG2814	Major facilitator Superfamily
A7E59_RS09810	COG0569	domain protein
A7E59_RS09810	COG0475	glutathione-regulated potassium exporter activity
A7E59_RS09815	COG2239	Acts as a magnesium transporter
A7E59_RS09820	COG0564	pseudouridine synthase activity
A7E59_RS09825	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A7E59_RS09830	COG2357	RelA SpoT domain protein
A7E59_RS09840	COG4116	CYTH
A7E59_RS09845	COG2346	COG2346, Truncated hemoglobins
A7E59_RS09870	COG1164	Oligoendopeptidase f
A7E59_RS09875	COG4862	establishment of competence for transformation
A7E59_RS09880	COG1393	Belongs to the ArsC family
A7E59_RS09900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7E59_RS09905	COG4166	transmembrane transport
A7E59_RS09910	COG4608	Belongs to the ABC transporter superfamily
A7E59_RS09915	COG0444	Belongs to the ABC transporter superfamily
A7E59_RS09920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7E59_RS09925	COG0601	transmembrane transport
A7E59_RS09945	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A7E59_RS09955	COG0542	response to heat
A7E59_RS09965	COG2151	metal-sulfur cluster biosynthetic enzyme
A7E59_RS09970	COG0561	phosphatase activity
A7E59_RS09975	COG0446	pyridine nucleotide-disulphide oxidoreductase
A7E59_RS09985	COG0179	Fumarylacetoacetate (FAA) hydrolase
A7E59_RS09990	COG1074	ATP-dependent DNA helicase activity
A7E59_RS09995	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
A7E59_RS10010	COG0398	Pfam SNARE associated Golgi protein
A7E59_RS10020	COG0137	argininosuccinate synthase activity
A7E59_RS10025	COG0165	Argininosuccinate lyase
A7E59_RS10040	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A7E59_RS10045	COG1012	belongs to the aldehyde dehydrogenase family
A7E59_RS10050	COG1902	pentaerythritol trinitrate reductase activity
A7E59_RS10055	COG1098	S1 RNA binding domain
A7E59_RS10060	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A7E59_RS10070	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A7E59_RS10080	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A7E59_RS10080	COG2111	Na H antiporter
A7E59_RS10085	COG2111	Na H antiporter
A7E59_RS10090	COG1006	Multisubunit Na H antiporter MnhC subunit
A7E59_RS10095	COG0651	ATP synthesis coupled electron transport
A7E59_RS10100	COG1863	multisubunit Na H antiporter MnhE subunit
A7E59_RS10105	COG2212	antiporter activity
A7E59_RS10120	COG2050	protein possibly involved in aromatic compounds catabolism
A7E59_RS10125	COG2056	Na+-H+ antiporter family
A7E59_RS10130	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A7E59_RS10135	COG1252	NADH dehydrogenase
A7E59_RS10140	COG0316	Belongs to the HesB IscA family
A7E59_RS10145	COG4844	belongs to the
A7E59_RS10150	COG1252	NADH dehydrogenase
A7E59_RS10155	COG0519	Catalyzes the synthesis of GMP from XMP
A7E59_RS10160	COG4837	Protein of unknown function (DUF1462)
A7E59_RS10165	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A7E59_RS10170	COG0789	Transcriptional regulator
A7E59_RS10180	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
A7E59_RS10185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A7E59_RS10190	COG1696	Membrane protein involved in D-alanine export
A7E59_RS10195	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A7E59_RS10205	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A7E59_RS10210	COG0647	UMP catabolic process
A7E59_RS10215	COG2445	Protein of unknown function DUF86
A7E59_RS10225	COG4470	Protein conserved in bacteria
A7E59_RS10230	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A7E59_RS10235	COG0737	Belongs to the 5'-nucleotidase family
A7E59_RS10240	COG0730	response to heat
A7E59_RS10245	COG1801	Protein of unknown function DUF72
A7E59_RS10255	COG4536	flavin adenine dinucleotide binding
A7E59_RS10265	COG0584	glycerophosphoryl diester phosphodiesterase
A7E59_RS10320	COG5434	Belongs to the glycosyl hydrolase 28 family
A7E59_RS10320	COG4632	Exopolysaccharide biosynthesis protein
A7E59_RS10395	COG0740	serine-type endopeptidase activity
A7E59_RS10430	COG0756	dUTP diphosphatase activity
A7E59_RS10475	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A7E59_RS10545	COG3617	BRO family, N-terminal domain
A7E59_RS10595	COG4974	Belongs to the 'phage' integrase family
A7E59_RS10600	COG0719	Fe-S assembly protein
A7E59_RS10605	COG0822	iron-sulfur transferase activity
A7E59_RS10610	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A7E59_RS10615	COG0719	Fe-S assembly protein
A7E59_RS10620	COG0396	ATPase activity
A7E59_RS10625	COG1464	Belongs to the NlpA lipoprotein family
A7E59_RS10630	COG2011	ABC-type metal ion transport system permease component
A7E59_RS10635	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A7E59_RS10640	COG3118	belongs to the thioredoxin family
A7E59_RS10645	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
A7E59_RS10650	COG0509	glycine decarboxylation via glycine cleavage system
A7E59_RS10655	COG1393	Belongs to the ArsC family
A7E59_RS10660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A7E59_RS10670	COG0710	3-dehydroquinate dehydratase activity
A7E59_RS10700	COG1704	LemA family
A7E59_RS10705	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A7E59_RS10725	COG1278	Cold shock
A7E59_RS10740	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A7E59_RS10755	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A7E59_RS10760	COG0557	exoribonuclease II activity
A7E59_RS10765	COG1647	Serine aminopeptidase, S33
A7E59_RS10770	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A7E59_RS10780	COG0148	phosphopyruvate hydratase activity
A7E59_RS10785	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A7E59_RS10790	COG0149	triose-phosphate isomerase activity
A7E59_RS10795	COG0126	phosphoglycerate kinase activity
A7E59_RS10800	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A7E59_RS10830	COG0740	serine-type endopeptidase activity
A7E59_RS10840	COG1114	Component of the transport system for branched-chain amino acids
A7E59_RS10845	COG2814	Major facilitator Superfamily
A7E59_RS10850	COG1481	regulation of sporulation
A7E59_RS10855	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A7E59_RS10860	COG1660	Displays ATPase and GTPase activities
A7E59_RS10875	COG0110	maltose O-acetyltransferase activity
A7E59_RS10880	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A7E59_RS10885	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
A7E59_RS10910	COG3942	CHAP domain
A7E59_RS10920	COG0653	protein targeting
A7E59_RS10925	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A7E59_RS10935	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
A7E59_RS10945	COG1739	Uncharacterized protein family UPF0029
A7E59_RS10950	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A7E59_RS10955	COG2199	diguanylate cyclase activity
A7E59_RS10970	COG2195	Cleaves the N-terminal amino acid of tripeptides
A7E59_RS10975	COG1929	Belongs to the glycerate kinase type-1 family
A7E59_RS10995	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A7E59_RS11010	COG4607	ABC-type enterochelin transport system periplasmic component
A7E59_RS11015	COG4604	ABC transporter, ATP-binding protein
A7E59_RS11020	COG4605	iron ion homeostasis
A7E59_RS11025	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7E59_RS11030	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A7E59_RS11035	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A7E59_RS11040	COG1780	Probably involved in ribonucleotide reductase function
A7E59_RS11045	COG0697	spore germination
A7E59_RS11050	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A7E59_RS11055	COG3104	oligopeptide transport
A7E59_RS11060	COG3104	oligopeptide transport
A7E59_RS11070	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A7E59_RS11075	COG1174	glycine betaine transport
A7E59_RS11085	COG0514	ATP-dependent DNA helicase (RecQ)
A7E59_RS11090	COG0488	(ABC) transporter
A7E59_RS11095	COG1368	sulfuric ester hydrolase activity
A7E59_RS11105	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A7E59_RS11120	COG0512	Glutamine amidotransferase of anthranilate synthase
A7E59_RS11120	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A7E59_RS11125	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A7E59_RS11130	COG0720	synthase
A7E59_RS11135	COG0602	queuosine metabolic process
A7E59_RS11150	COG0656	L-ascorbic acid biosynthetic process
A7E59_RS11155	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
A7E59_RS11180	COG1253	flavin adenine dinucleotide binding
A7E59_RS11185	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7E59_RS11185	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A7E59_RS11185	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A7E59_RS11190	COG1105	Belongs to the carbohydrate kinase PfkB family
A7E59_RS11195	COG1349	DNA-binding transcription factor activity
A7E59_RS11200	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A7E59_RS11235	COG0471	metal ion transport
A7E59_RS11240	COG0039	L-malate dehydrogenase activity
A7E59_RS11245	COG0586	Pfam SNARE associated Golgi protein
A7E59_RS11255	COG4989	oxidoreductase activity
A7E59_RS11260	COG0523	cobalamin synthesis protein
A7E59_RS11270	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A7E59_RS11275	COG4988	ABC transporter
A7E59_RS11280	COG1968	undecaprenyl-diphosphatase activity
A7E59_RS11290	COG1671	Belongs to the UPF0178 family
A7E59_RS11320	COG2839	Protein conserved in bacteria
A7E59_RS11325	COG2814	Major facilitator Superfamily
A7E59_RS11330	COG0583	DNA-binding transcription factor activity
A7E59_RS11345	COG0217	transcriptional regulatory protein
A7E59_RS11355	COG2207	Transcriptional regulator
A7E59_RS11355	COG0662	Cupin 2, conserved barrel domain protein
A7E59_RS11365	COG1388	LysM domain
A7E59_RS11365	COG3942	CHAP domain
A7E59_RS11370	COG1733	regulation of RNA biosynthetic process
A7E59_RS11375	COG2814	Major facilitator Superfamily
A7E59_RS11385	COG0306	phosphate transporter
A7E59_RS11390	COG1392	Phosphate transport regulator
A7E59_RS11395	COG0577	efflux transmembrane transporter activity
A7E59_RS11400	COG0577	efflux transmembrane transporter activity
A7E59_RS11405	COG0577	efflux transmembrane transporter activity
A7E59_RS11410	COG1136	(ABC) transporter
A7E59_RS11415	COG2205	protein histidine kinase activity
A7E59_RS11420	COG0745	RESPONSE REGULATOR receiver
A7E59_RS11430	COG0657	acetylesterase activity
A7E59_RS11435	COG3949	Membrane
A7E59_RS11445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7E59_RS11450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7E59_RS11455	COG1120	ATPase activity
A7E59_RS11460	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A7E59_RS11465	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A7E59_RS11470	COG1132	(ABC) transporter
A7E59_RS11475	COG1686	Belongs to the peptidase S11 family
A7E59_RS11480	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A7E59_RS11490	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A7E59_RS11495	COG1682	transport, permease protein
A7E59_RS11505	COG5609	conserved protein (DUF2294)
A7E59_RS11510	COG3949	Membrane
A7E59_RS11520	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A7E59_RS11525	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
A7E59_RS11530	COG0110	maltose O-acetyltransferase activity
A7E59_RS11550	COG0671	phosphoesterase, PA-phosphatase related
A7E59_RS11560	COG1121	(ABC) transporter
A7E59_RS11565	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A7E59_RS11570	COG0803	Belongs to the bacterial solute-binding protein 9 family
A7E59_RS11575	COG0025	NhaP-type Na H and K H
A7E59_RS11625	COG0546	phosphoglycolate phosphatase activity
A7E59_RS11630	COG4139	cobalamin transport
A7E59_RS11635	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A7E59_RS11640	COG0018	arginyl-trna synthetase
A7E59_RS11650	COG1473	amidohydrolase
A7E59_RS11655	COG4115	mRNA cleavage
A7E59_RS11675	COG1279	arginine transmembrane transporter activity
A7E59_RS11685	COG1078	dGTPase activity
A7E59_RS11690	COG0519	Catalyzes the synthesis of GMP from XMP
A7E59_RS11705	COG4844	belongs to the
A7E59_RS11725	COG0095	Lipoate-protein ligase
A7E59_RS11730	COG0280	phosphate acetyltransferase
A7E59_RS11735	COG3253	May function as heme-dependent peroxidase
A7E59_RS11755	COG0586	Pfam SNARE associated Golgi protein
A7E59_RS11760	COG0531	amino acid
A7E59_RS11765	COG2363	Small membrane protein
A7E59_RS11775	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A7E59_RS11790	COG1469	GTP cyclohydrolase I activity
A7E59_RS11795	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A7E59_RS11800	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A7E59_RS11805	COG0363	glucosamine-6-phosphate deaminase activity
A7E59_RS11810	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
A7E59_RS11820	COG0431	NADPH-dependent FMN reductase
A7E59_RS11825	COG0561	phosphatase activity
A7E59_RS11835	COG1428	Deoxynucleoside kinase
A7E59_RS11840	COG1428	Deoxynucleoside kinase
A7E59_RS11845	COG0561	phosphatase activity
A7E59_RS11855	COG0546	phosphoglycolate phosphatase activity
A7E59_RS11860	COG2832	Protein of unknown function (DUF454)
A7E59_RS11865	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A7E59_RS11890	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
A7E59_RS11900	COG1473	amidohydrolase
A7E59_RS11905	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A7E59_RS11910	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A7E59_RS11915	COG0049	tRNA binding
A7E59_RS11920	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A7E59_RS11940	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A7E59_RS11945	COG0085	RNA polymerase activity
A7E59_RS11950	COG2813	Specifically methylates the guanine in position
A7E59_RS11960	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A7E59_RS11965	COG0081	regulation of translation
A7E59_RS11970	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A7E59_RS11975	COG0250	Participates in transcription elongation, termination and antitermination
A7E59_RS11980	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A7E59_RS11985	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A7E59_RS12000	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A7E59_RS12005	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
A7E59_RS12010	COG0215	cysteine-tRNA ligase activity
A7E59_RS12015	COG1045	serine acetyltransferase
A7E59_RS12020	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A7E59_RS12025	COG4956	integral membrane protein (PIN domain superfamily)
A7E59_RS12030	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A7E59_RS12035	COG0542	response to heat
A7E59_RS12040	COG3869	Catalyzes the specific phosphorylation of arginine residues in
A7E59_RS12055	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A7E59_RS12070	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
A7E59_RS12075	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
A7E59_RS12080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7E59_RS12090	COG2814	Major facilitator Superfamily
A7E59_RS12175	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A7E59_RS12180	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A7E59_RS12185	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A7E59_RS12190	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A7E59_RS12205	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A7E59_RS12210	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A7E59_RS12225	COG1098	S1 RNA binding domain
A7E59_RS12235	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A7E59_RS12240	COG3956	TIGRFAM MazG family protein
A7E59_RS12245	COG2244	polysaccharide biosynthetic process
A7E59_RS12250	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A7E59_RS12255	COG0193	aminoacyl-tRNA hydrolase activity
A7E59_RS12260	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A7E59_RS12270	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A7E59_RS12275	COG2088	sporulation resulting in formation of a cellular spore
A7E59_RS12280	COG0251	oxidation-reduction process
A7E59_RS12285	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A7E59_RS12295	COG4466	Protein conserved in bacteria
A7E59_RS12300	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A7E59_RS12305	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
A7E59_RS12310	COG0084	hydrolase, TatD family'
A7E59_RS12315	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A7E59_RS12315	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A7E59_RS12325	COG4152	abc transporter atp-binding protein
A7E59_RS12330	COG3842	ATPase activity
A7E59_RS12365	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A7E59_RS12370	COG2827	Endonuclease containing a URI domain
A7E59_RS12375	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A7E59_RS12385	COG1774	PSP1 C-terminal conserved region
A7E59_RS12390	COG0470	DNA polymerase III
A7E59_RS12395	COG3870	Protein conserved in bacteria
A7E59_RS12400	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A7E59_RS12405	COG1982	Orn Lys Arg decarboxylase major
A7E59_RS12425	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A7E59_RS12430	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A7E59_RS12435	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A7E59_RS12450	COG2814	Major facilitator Superfamily
A7E59_RS12455	COG0583	DNA-binding transcription factor activity
A7E59_RS12470	COG0640	Transcriptional regulator
A7E59_RS12475	COG2188	Transcriptional regulator
A7E59_RS12480	COG0366	Alpha amylase catalytic
A7E59_RS12485	COG1263	PTS System
A7E59_RS12485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7E59_RS12490	COG0346	lactoylglutathione lyase activity
A7E59_RS12500	COG0493	'glutamate synthase
A7E59_RS12505	COG0070	glutamate synthase
A7E59_RS12505	COG0069	glutamate synthase activity
A7E59_RS12505	COG0067	glutamate synthase
A7E59_RS12510	COG0583	DNA-binding transcription factor activity
A7E59_RS12545	COG4841	protein insertion into membrane
A7E59_RS12550	COG0494	nUDIX hydrolase
A7E59_RS12555	COG4841	protein insertion into membrane
A7E59_RS12565	COG0737	Belongs to the 5'-nucleotidase family
A7E59_RS12580	COG3246	L-lysine catabolic process to acetate
A7E59_RS12585	COG1250	3-hydroxyacyl-CoA dehydrogenase
A7E59_RS12595	COG1279	arginine transmembrane transporter activity
A7E59_RS12600	COG0626	cystathionine gamma-synthase activity
A7E59_RS12605	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A7E59_RS12610	COG0733	neurotransmitter:sodium symporter activity
A7E59_RS12620	COG1647	Serine aminopeptidase, S33
A7E59_RS12625	COG1755	Isoprenylcysteine carboxyl methyltransferase
A7E59_RS12670	COG0346	lactoylglutathione lyase activity
A7E59_RS12685	COG1695	Transcriptional regulator
A7E59_RS12690	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A7E59_RS12715	COG0529	Catalyzes the synthesis of activated sulfate
A7E59_RS12720	COG2046	Belongs to the sulfate adenylyltransferase family
A7E59_RS12725	COG0730	response to heat
A7E59_RS12730	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A7E59_RS12735	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A7E59_RS12740	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A7E59_RS12745	COG0175	sulfate reduction
A7E59_RS12750	COG0488	(ABC) transporter
A7E59_RS12755	COG0488	(ABC) transporter
A7E59_RS12760	COG1216	Glycosyl transferase, family 2
A7E59_RS12780	COG2514	catechol 2,3-dioxygenase activity
A7E59_RS12785	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A7E59_RS12785	COG0519	Catalyzes the synthesis of GMP from XMP
A7E59_RS12790	COG0516	GMP reductase activity
A7E59_RS12790	COG0517	IMP dehydrogenase activity
A7E59_RS12795	COG2233	PERMEase
A7E59_RS12820	COG1823	symporter activity
A7E59_RS12825	COG0778	Nitroreductase
A7E59_RS12835	COG0450	alkyl hydroperoxide reductase
A7E59_RS12840	COG3634	alkyl hydroperoxide reductase activity
A7E59_RS12860	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A7E59_RS12865	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A7E59_RS12890	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A7E59_RS12900	COG0360	Binds together with S18 to 16S ribosomal RNA
A7E59_RS12920	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A7E59_RS12955	COG0012	GTP binding
A7E59_RS12960	COG4481	Protein conserved in bacteria
A7E59_RS12965	COG0668	transmembrane transport
A7E59_RS12970	COG1475	DNA binding
A7E59_RS12975	COG0626	cystathionine gamma-synthase activity
A7E59_RS12985	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A7E59_RS12995	COG0436	Aminotransferase
A7E59_RS13020	COG1475	DNA binding
A7E59_RS13025	COG0357	Ribosomal RNA small subunit methyltransferase G
A7E59_RS13030	COG0445	tRNA wobble uridine modification
A7E59_RS13035	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A7E59_RS13040	COG0594	ribonuclease P activity