locus-tag	class	description
A2I66_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A2I66_RS00010	COG0592	DNA-directed DNA polymerase activity
A2I66_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A2I66_RS00025	COG0187	DNA topoisomerase II activity
A2I66_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A2I66_RS00050	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A2I66_RS00065	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
A2I66_RS00070	COG0359	binds to the 23S rRNA
A2I66_RS00075	COG0305	Participates in initiation and elongation during chromosome replication
A2I66_RS00100	COG0745	RESPONSE REGULATOR receiver
A2I66_RS00110	COG4863	YycH protein
A2I66_RS00120	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A2I66_RS00125	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A2I66_RS00135	COG0640	Transcriptional regulator
A2I66_RS00140	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A2I66_RS00145	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A2I66_RS00160	COG0640	Transcriptional regulator
A2I66_RS00190	COG2003	Belongs to the UPF0758 family
A2I66_RS00255	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A2I66_RS00260	COG0022	dehydrogenase e1 component
A2I66_RS00265	COG0508	dehydrogenase complex catalyzes the overall conversion of
A2I66_RS00325	COG2003	Belongs to the UPF0758 family
A2I66_RS00350	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A2I66_RS00355	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A2I66_RS00355	COG1215	transferase activity, transferring glycosyl groups
A2I66_RS00360	COG2217	Heavy metal translocating P-type atpase
A2I66_RS00365	COG1388	LysM domain
A2I66_RS00370	COG0730	response to heat
A2I66_RS00375	COG1937	Protein conserved in bacteria
A2I66_RS00380	COG2210	Belongs to the sulfur carrier protein TusA family
A2I66_RS00385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A2I66_RS00400	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A2I66_RS00410	COG0789	Transcriptional regulator
A2I66_RS00420	COG0702	epimerase
A2I66_RS00425	COG2130	NADP-dependent
A2I66_RS00445	COG0702	epimerase
A2I66_RS00450	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
A2I66_RS00505	COG0477	Major facilitator Superfamily
A2I66_RS00515	COG0076	glutamate decarboxylase activity
A2I66_RS00530	COG2814	Major facilitator Superfamily
A2I66_RS00540	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A2I66_RS00540	COG3711	transcriptional antiterminator
A2I66_RS00545	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A2I66_RS00545	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A2I66_RS00545	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A2I66_RS00550	COG1482	cell wall glycoprotein biosynthetic process
A2I66_RS00560	COG0640	Transcriptional regulator
A2I66_RS00595	COG3942	CHAP domain
A2I66_RS00595	COG1705	Flagellar rod assembly protein muramidase FlgJ
A2I66_RS00650	COG1136	(ABC) transporter
A2I66_RS00685	COG1609	Transcriptional regulator
A2I66_RS00695	COG1869	D-ribose catabolic process
A2I66_RS00710	COG0183	Belongs to the thiolase family
A2I66_RS00720	COG1960	acyl-CoA dehydrogenase activity
A2I66_RS00725	COG0318	PFAM AMP-dependent synthetase and ligase
A2I66_RS00750	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A2I66_RS00790	COG0598	Magnesium transport protein CorA
A2I66_RS00800	COG0363	glucosamine-6-phosphate deaminase activity
A2I66_RS00805	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
A2I66_RS00810	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A2I66_RS00810	COG0517	IMP dehydrogenase activity
A2I66_RS00820	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A2I66_RS00825	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A2I66_RS00835	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A2I66_RS00845	COG2226	methyltransferase
A2I66_RS00860	COG0778	Nitroreductase
A2I66_RS00890	COG1012	belongs to the aldehyde dehydrogenase family
A2I66_RS00905	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A2I66_RS00930	COG1028	Short-chain dehydrogenase reductase Sdr
A2I66_RS00940	COG1012	belongs to the aldehyde dehydrogenase family
A2I66_RS00950	COG2851	Citrate transporter
A2I66_RS00970	COG1472	Belongs to the glycosyl hydrolase 3 family
A2I66_RS00980	COG0730	response to heat
A2I66_RS00995	COG0753	catalase activity
A2I66_RS01000	COG1063	alcohol dehydrogenase
A2I66_RS01015	COG1902	pentaerythritol trinitrate reductase activity
A2I66_RS01015	COG0446	pyridine nucleotide-disulphide oxidoreductase
A2I66_RS01020	COG0640	Transcriptional regulator
A2I66_RS01030	COG4640	response to antibiotic
A2I66_RS01050	COG1401	restriction endodeoxyribonuclease activity
A2I66_RS01070	COG3732	PTS system glucitol sorbitol-specific
A2I66_RS01075	COG3730	PTS system glucitol sorbitol-specific
A2I66_RS01100	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A2I66_RS01135	COG1966	Carbon starvation protein
A2I66_RS01165	COG1054	Belongs to the UPF0176 family
A2I66_RS01185	COG2388	GCN5-related N-acetyl-transferase
A2I66_RS01190	COG0346	lactoylglutathione lyase activity
A2I66_RS01205	COG0789	Transcriptional regulator
A2I66_RS01215	COG0477	Major facilitator Superfamily
A2I66_RS01225	COG0667	Aldo Keto reductase
A2I66_RS01235	COG1028	Short-chain dehydrogenase reductase Sdr
A2I66_RS01245	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A2I66_RS01275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A2I66_RS01280	COG1028	Short-chain dehydrogenase reductase Sdr
A2I66_RS01305	COG1288	antiporter activity
A2I66_RS01315	COG3871	stress protein (general stress protein 26)
A2I66_RS01320	COG1929	Belongs to the glycerate kinase type-1 family
A2I66_RS01325	COG1511	domain protein
A2I66_RS01335	COG0604	alcohol dehydrogenase
A2I66_RS01340	COG0300	oxidoreductase activity
A2I66_RS01350	COG0579	oxidoreductase
A2I66_RS01355	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A2I66_RS01370	COG0561	phosphatase activity
A2I66_RS01375	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A2I66_RS01380	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A2I66_RS01385	COG1757	Na H antiporter
A2I66_RS01390	COG2326	polyphosphate kinase activity
A2I66_RS01400	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A2I66_RS01415	COG0596	Alpha beta hydrolase
A2I66_RS01425	COG4195	phage-related replication protein
A2I66_RS01455	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A2I66_RS01490	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A2I66_RS01495	COG0549	Belongs to the carbamate kinase family
A2I66_RS01500	COG1288	antiporter activity
A2I66_RS01510	COG1288	antiporter activity
A2I66_RS01520	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A2I66_RS01535	COG0706	membrane insertase activity
A2I66_RS01555	COG0583	DNA-binding transcription factor activity
A2I66_RS01560	COG3842	ATPase activity
A2I66_RS01565	COG1840	ABC-type Fe3 transport system, periplasmic component
A2I66_RS01600	COG1028	Short-chain dehydrogenase reductase Sdr
A2I66_RS01625	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A2I66_RS01630	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A2I66_RS01645	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A2I66_RS01650	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A2I66_RS01685	COG0069	glutamate synthase activity
A2I66_RS01690	COG2814	Major facilitator Superfamily
A2I66_RS01700	COG2837	iron assimilation
A2I66_RS01705	COG0672	)-iron permease
A2I66_RS01710	COG0805	protein transport
A2I66_RS01715	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A2I66_RS01720	COG4336	lyase activity
A2I66_RS01725	COG0753	catalase activity
A2I66_RS01735	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A2I66_RS01780	COG0201	protein transport
A2I66_RS01790	COG1073	alpha beta
A2I66_RS01820	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A2I66_RS01850	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A2I66_RS01855	COG2011	ABC-type metal ion transport system permease component
A2I66_RS01890	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A2I66_RS01895	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
A2I66_RS01910	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A2I66_RS01970	COG3961	Belongs to the TPP enzyme family
A2I66_RS01980	COG1510	regulation of RNA biosynthetic process
A2I66_RS01985	COG1012	belongs to the aldehyde dehydrogenase family
A2I66_RS01990	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
A2I66_RS01995	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A2I66_RS02000	COG1181	Belongs to the D-alanine--D-alanine ligase family
A2I66_RS02030	COG1368	sulfuric ester hydrolase activity
A2I66_RS02040	COG2409	Drug exporters of the RND superfamily
A2I66_RS02045	COG0463	Glycosyl transferase, family 2
A2I66_RS02045	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A2I66_RS02055	COG0494	nUDIX hydrolase
A2I66_RS02065	COG0563	adenylate kinase activity
A2I66_RS02075	COG3588	fructose-bisphosphate aldolase
A2I66_RS02080	COG2258	MOSC domain
A2I66_RS02105	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A2I66_RS02110	COG1263	PTS System
A2I66_RS02110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A2I66_RS02115	COG1737	Transcriptional regulator
A2I66_RS02160	COG0582	viral genome integration into host DNA
A2I66_RS02165	COG2111	Na H antiporter
A2I66_RS02165	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A2I66_RS02170	COG2111	Na H antiporter
A2I66_RS02175	COG1006	Multisubunit Na H antiporter MnhC subunit
A2I66_RS02185	COG1863	multisubunit Na H antiporter MnhE subunit
A2I66_RS02190	COG2212	antiporter activity
A2I66_RS02195	COG1320	monovalent cation:proton antiporter activity
A2I66_RS02210	COG1113	amino acid transport
A2I66_RS02235	COG2824	Alkylphosphonate utilization operon protein PhnA
A2I66_RS02245	COG2376	Dihydroxyacetone kinase
A2I66_RS02250	COG1461	Dihydroxyacetone kinase
A2I66_RS02260	COG0438	transferase activity, transferring glycosyl groups
A2I66_RS02265	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A2I66_RS02265	COG0463	Glycosyl transferase, family 2
A2I66_RS02270	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A2I66_RS02275	COG0463	Glycosyl transferase, family 2
A2I66_RS02275	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A2I66_RS02285	COG0531	amino acid
A2I66_RS02305	COG0463	Glycosyl transferase, family 2
A2I66_RS02310	COG0446	pyridine nucleotide-disulphide oxidoreductase
A2I66_RS02325	COG1959	2 iron, 2 sulfur cluster binding
A2I66_RS02330	COG1131	(ABC) transporter
A2I66_RS02350	COG1028	Short-chain dehydrogenase reductase Sdr
A2I66_RS02370	COG0318	PFAM AMP-dependent synthetase and ligase
A2I66_RS02375	COG0183	Belongs to the thiolase family
A2I66_RS02385	COG2235	arginine
A2I66_RS02390	COG2235	arginine
A2I66_RS02400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A2I66_RS02405	COG1438	arginine binding
A2I66_RS02420	COG2022	thiamine diphosphate biosynthetic process
A2I66_RS02430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A2I66_RS02450	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A2I66_RS02475	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A2I66_RS02490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A2I66_RS02500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A2I66_RS02505	COG2508	Transcriptional regulator
A2I66_RS02510	COG1953	Uracil, thiamine, allantoin
A2I66_RS02520	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A2I66_RS02535	COG0439	Biotin carboxylase
A2I66_RS02540	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A2I66_RS02545	COG1914	H( )-stimulated, divalent metal cation uptake system
A2I66_RS02550	COG1070	Carbohydrate kinase
A2I66_RS02565	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A2I66_RS02575	COG1695	Transcriptional regulator
A2I66_RS02605	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A2I66_RS02620	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A2I66_RS02635	COG3189	MarR family transcriptional regulator
A2I66_RS02650	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A2I66_RS02665	COG0604	alcohol dehydrogenase
A2I66_RS02670	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
A2I66_RS02675	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A2I66_RS02685	COG3001	Fructosamine kinase
A2I66_RS02700	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A2I66_RS02715	COG3764	Sortase (surface protein transpeptidase)
A2I66_RS02720	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A2I66_RS02730	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A2I66_RS02750	COG1136	(ABC) transporter
A2I66_RS02755	COG0577	efflux transmembrane transporter activity
A2I66_RS02760	COG0583	DNA-binding transcription factor activity
A2I66_RS02775	COG0028	Belongs to the TPP enzyme family
A2I66_RS02785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A2I66_RS02795	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A2I66_RS02800	COG1687	branched-chain amino acid
A2I66_RS02805	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
A2I66_RS02830	COG1760	l-serine dehydratase
A2I66_RS02835	COG1760	l-serine dehydratase
A2I66_RS02850	COG0778	Nitroreductase
A2I66_RS02860	COG1132	(ABC) transporter
A2I66_RS02865	COG1132	(ABC) transporter
A2I66_RS02875	COG0803	Belongs to the bacterial solute-binding protein 9 family
A2I66_RS02880	COG1846	Transcriptional regulator
A2I66_RS02885	COG0346	lactoylglutathione lyase activity
A2I66_RS02890	COG2211	Major facilitator Superfamily
A2I66_RS02895	COG2207	Transcriptional regulator
A2I66_RS02900	COG3250	beta-galactosidase activity
A2I66_RS02905	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
A2I66_RS02910	COG1131	(ABC) transporter
A2I66_RS02920	COG0586	Pfam SNARE associated Golgi protein
A2I66_RS02925	COG2271	Major facilitator Superfamily
A2I66_RS02935	COG3527	Alpha-acetolactate decarboxylase
A2I66_RS02945	COG4876	unkown
A2I66_RS02950	COG0523	cobalamin synthesis protein
A2I66_RS02955	COG2357	RelA SpoT domain protein
A2I66_RS02970	COG2808	Putative FMN-binding domain
A2I66_RS02980	COG1070	Carbohydrate kinase
A2I66_RS02985	COG2610	gluconate transmembrane transporter activity
A2I66_RS02995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A2I66_RS03000	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A2I66_RS03025	COG4619	ABC transporter
A2I66_RS03030	COG0390	transport system, permease component
A2I66_RS03035	COG2814	Major facilitator Superfamily
A2I66_RS03040	COG2272	Belongs to the type-B carboxylesterase lipase family
A2I66_RS03050	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
A2I66_RS03060	COG1174	glycine betaine transport
A2I66_RS03070	COG1174	glycine betaine transport
A2I66_RS03080	COG1309	transcriptional regulator
A2I66_RS03095	COG1346	cytolysis
A2I66_RS03105	COG3279	Response regulator of the LytR AlgR family
A2I66_RS03110	COG3275	phosphorelay sensor kinase activity
A2I66_RS03125	COG0531	amino acid
A2I66_RS03130	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
A2I66_RS03135	COG1113	amino acid transport
A2I66_RS03145	COG2814	Major facilitator Superfamily
A2I66_RS03155	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A2I66_RS03160	COG0741	lytic transglycosylase activity
A2I66_RS03165	COG0588	phosphoglycerate mutase activity
A2I66_RS03175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A2I66_RS03180	COG0765	amino acid transport
A2I66_RS03185	COG1126	abc transporter atp-binding protein
A2I66_RS03210	COG2353	YceI-like domain
A2I66_RS03225	COG2116	formate transmembrane transporter activity
A2I66_RS03240	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A2I66_RS03245	COG2146	nitrite reductase [NAD(P)H] activity
A2I66_RS03250	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A2I66_RS03250	COG1648	precorrin-2 dehydrogenase activity
A2I66_RS03255	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
A2I66_RS03260	COG1140	nitrate reductase beta subunit
A2I66_RS03270	COG2181	nitrate reductase activity
A2I66_RS03280	COG4585	Histidine kinase
A2I66_RS03285	COG2197	response regulator
A2I66_RS03290	COG2223	nitrite transmembrane transporter activity
A2I66_RS03295	COG0772	Belongs to the SEDS family
A2I66_RS03300	COG3425	synthase
A2I66_RS03320	COG1846	Transcriptional regulator
A2I66_RS03365	COG0492	ferredoxin-NADP+ reductase activity
A2I66_RS03370	COG2814	Major facilitator Superfamily
A2I66_RS03375	COG0604	alcohol dehydrogenase
A2I66_RS03385	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A2I66_RS03390	COG1620	l-lactate permease
A2I66_RS03395	COG0438	transferase activity, transferring glycosyl groups
A2I66_RS03405	COG3850	Histidine kinase
A2I66_RS03405	COG5002	protein histidine kinase activity
A2I66_RS03410	COG0745	RESPONSE REGULATOR receiver
A2I66_RS03415	COG0577	efflux transmembrane transporter activity
A2I66_RS03420	COG1136	(ABC) transporter
A2I66_RS03435	COG4640	response to antibiotic
A2I66_RS03440	COG2814	Major facilitator Superfamily
A2I66_RS03445	COG1033	growth of symbiont in host cell
A2I66_RS03445	COG2409	Drug exporters of the RND superfamily
A2I66_RS03455	COG1566	PFAM secretion protein HlyD family protein
A2I66_RS03460	COG2814	Major facilitator Superfamily
A2I66_RS03480	COG0598	Magnesium transport protein CorA
A2I66_RS03485	COG1304	FMN binding
A2I66_RS03495	COG1328	CTP reductase activity
A2I66_RS03500	COG0602	queuosine metabolic process
A2I66_RS03505	COG2094	Belongs to the DNA glycosylase MPG family
A2I66_RS03510	COG3152	Membrane
A2I66_RS03535	COG4152	abc transporter atp-binding protein
A2I66_RS03540	COG1668	transmembrane transport
A2I66_RS03545	COG1742	UPF0060 membrane protein
A2I66_RS03550	COG2017	converts alpha-aldose to the beta-anomer
A2I66_RS03555	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A2I66_RS03560	COG1266	CAAX protease self-immunity
A2I66_RS03570	COG0583	DNA-binding transcription factor activity
A2I66_RS03575	COG3314	Sporulation integral membrane protein YlbJ
A2I66_RS03580	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A2I66_RS03585	COG1228	amidohydrolase
A2I66_RS03590	COG0659	secondary active sulfate transmembrane transporter activity
A2I66_RS03595	COG1473	amidohydrolase
A2I66_RS03600	COG1028	Short-chain dehydrogenase reductase Sdr
A2I66_RS03605	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A2I66_RS03620	COG2271	Major facilitator Superfamily
A2I66_RS03635	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A2I66_RS03660	COG1113	amino acid transport
A2I66_RS03665	COG1737	Transcriptional regulator
A2I66_RS03700	COG3383	formate dehydrogenase (NAD+) activity
A2I66_RS03725	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A2I66_RS03730	COG2076	Multidrug Resistance protein
A2I66_RS03735	COG2076	Multidrug Resistance protein
A2I66_RS03750	COG1757	Na H antiporter
A2I66_RS03760	COG3942	CHAP domain
A2I66_RS03790	COG0830	nickel cation binding
A2I66_RS03795	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
A2I66_RS03800	COG0804	urea catabolic process
A2I66_RS03810	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A2I66_RS03815	COG1960	acyl-CoA dehydrogenase activity
A2I66_RS03820	COG1957	nucleoside hydrolase
A2I66_RS03825	COG1268	BioY protein
A2I66_RS03835	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A2I66_RS03840	COG1609	Transcriptional regulator
A2I66_RS03845	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A2I66_RS03850	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A2I66_RS03855	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
A2I66_RS03860	COG0725	ABC transporter, periplasmic molybdate-binding protein
A2I66_RS03865	COG4149	molybdate abc transporter
A2I66_RS03870	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A2I66_RS03875	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A2I66_RS03880	COG0521	Mo-molybdopterin cofactor biosynthetic process
A2I66_RS03885	COG0315	cyclic pyranopterin monophosphate synthase activity
A2I66_RS03900	COG0314	molybdopterin synthase activity
A2I66_RS03910	COG0746	molybdenum cofactor guanylyltransferase activity
A2I66_RS03915	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A2I66_RS03925	COG2814	Major facilitator Superfamily
A2I66_RS03945	COG2348	transferase activity, transferring amino-acyl groups
A2I66_RS03950	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A2I66_RS03985	COG4975	Glucose uptake
A2I66_RS03995	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A2I66_RS03995	COG0551	DNA topoisomerase type I activity
A2I66_RS04000	COG2252	PERMEase
A2I66_RS04015	COG0051	transcription antitermination factor activity, RNA binding
A2I66_RS04020	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A2I66_RS04025	COG0088	Forms part of the polypeptide exit tunnel
A2I66_RS04030	COG0089	rRNA binding
A2I66_RS04035	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A2I66_RS04040	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A2I66_RS04045	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A2I66_RS04050	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A2I66_RS04055	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A2I66_RS04065	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A2I66_RS04070	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A2I66_RS04075	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A2I66_RS04080	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A2I66_RS04085	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A2I66_RS04090	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A2I66_RS04095	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A2I66_RS04100	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A2I66_RS04105	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A2I66_RS04110	COG1841	ribosomal large subunit assembly
A2I66_RS04115	COG0200	Binds to the 23S rRNA
A2I66_RS04120	COG0201	protein transport
A2I66_RS04125	COG0563	adenylate kinase activity
A2I66_RS04135	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A2I66_RS04140	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A2I66_RS04145	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A2I66_RS04150	COG0202	RNA polymerase activity
A2I66_RS04155	COG0203	ribosomal protein L17
A2I66_RS04175	COG0101	tRNA pseudouridine synthase activity
A2I66_RS04180	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A2I66_RS04185	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A2I66_RS04190	COG1846	Transcriptional regulator
A2I66_RS04200	COG1335	isochorismatase
A2I66_RS04220	COG2318	DinB family
A2I66_RS04225	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A2I66_RS04225	COG0574	Belongs to the PEP-utilizing enzyme family
A2I66_RS04230	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A2I66_RS04235	COG2130	NADP-dependent
A2I66_RS04245	COG2130	NADP-dependent
A2I66_RS04250	COG0604	alcohol dehydrogenase
A2I66_RS04270	COG1302	Protein conserved in bacteria
A2I66_RS04280	COG2814	Major facilitator Superfamily
A2I66_RS04285	COG4264	IucA IucC family
A2I66_RS04290	COG3457	Alanine racemase
A2I66_RS04295	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
A2I66_RS04300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A2I66_RS04305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A2I66_RS04310	COG3314	Sporulation integral membrane protein YlbJ
A2I66_RS04315	COG2329	Antibiotic biosynthesis monooxygenase
A2I66_RS04330	COG1988	membrane-bound metal-dependent
A2I66_RS04335	COG4284	Utp--glucose-1-phosphate uridylyltransferase
A2I66_RS04340	COG1272	protein, Hemolysin III
A2I66_RS04355	COG2814	Major facilitator Superfamily
A2I66_RS04360	COG0489	protein tyrosine kinase activity
A2I66_RS04410	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A2I66_RS04415	COG4856	YbbR-like protein
A2I66_RS04420	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A2I66_RS04425	COG1285	pathogenesis
A2I66_RS04435	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A2I66_RS04440	COG3711	transcriptional antiterminator
A2I66_RS04480	COG0640	Transcriptional regulator
A2I66_RS04485	COG0702	epimerase
A2I66_RS04490	COG2186	Transcriptional regulator
A2I66_RS04495	COG1482	cell wall glycoprotein biosynthetic process
A2I66_RS04515	COG0783	Belongs to the Dps family
A2I66_RS04520	COG1876	peptidase activity
A2I66_RS04525	COG0813	purine-nucleoside phosphorylase activity
A2I66_RS04530	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A2I66_RS04540	COG1854	S-ribosylhomocysteine lyase activity
A2I66_RS04560	COG5146	pantothenate kinase activity
A2I66_RS04570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A2I66_RS04575	COG3343	RNA polymerase activity
A2I66_RS04580	COG0504	CTP synthase activity
A2I66_RS04590	COG0191	fructose-bisphosphate aldolase activity
A2I66_RS04595	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A2I66_RS04605	COG1012	belongs to the aldehyde dehydrogenase family
A2I66_RS04610	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A2I66_RS04615	COG0254	rRNA binding
A2I66_RS04625	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A2I66_RS04630	COG2890	protein-(glutamine-N5) methyltransferase activity
A2I66_RS04635	COG0009	L-threonylcarbamoyladenylate synthase
A2I66_RS04640	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A2I66_RS04645	COG4475	Protein of unknown function (DUF436)
A2I66_RS04650	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A2I66_RS04655	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A2I66_RS04660	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A2I66_RS04670	COG0356	it plays a direct role in the translocation of protons across the membrane
A2I66_RS04675	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A2I66_RS04680	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A2I66_RS04685	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A2I66_RS04695	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A2I66_RS04700	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A2I66_RS04705	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A2I66_RS04715	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A2I66_RS04720	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A2I66_RS04730	COG0629	single-stranded DNA binding
A2I66_RS04735	COG1388	LysM domain
A2I66_RS04740	COG1388	LysM domain
A2I66_RS04755	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A2I66_RS04765	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
A2I66_RS04770	COG0352	thiamine-phosphate diphosphorylase activity
A2I66_RS04775	COG0706	membrane insertase activity
A2I66_RS04785	COG1418	mRNA catabolic process
A2I66_RS04790	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A2I66_RS04795	COG1937	Protein conserved in bacteria
A2I66_RS04810	COG2217	Heavy metal translocating P-type atpase
A2I66_RS04820	COG0772	Belongs to the SEDS family
A2I66_RS04825	COG1181	Belongs to the D-alanine--D-alanine ligase family
A2I66_RS04830	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A2I66_RS04850	COG3402	PFAM membrane-flanked domain
A2I66_RS04855	COG0736	holo-[acyl-carrier-protein] synthase activity
A2I66_RS04860	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A2I66_RS04875	COG2208	phosphoserine phosphatase activity
A2I66_RS04890	COG1191	sigma factor activity
A2I66_RS04895	COG2183	response to ionizing radiation
A2I66_RS04900	COG3091	SprT-like family
A2I66_RS04935	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A2I66_RS04940	COG0473	3-isopropylmalate dehydrogenase activity
A2I66_RS04945	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A2I66_RS04950	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A2I66_RS04955	COG0440	acetolactate synthase activity
A2I66_RS04960	COG0028	Belongs to the TPP enzyme family
A2I66_RS04965	COG0129	dihydroxy-acid dehydratase activity
A2I66_RS04970	COG0802	atpase or kinase
A2I66_RS04975	COG1214	PFAM Peptidase M22, glycoprotease
A2I66_RS04980	COG0456	acetyltransferase
A2I66_RS04985	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A2I66_RS04990	COG0488	(ABC) transporter
A2I66_RS04995	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
A2I66_RS05000	COG0425	Belongs to the sulfur carrier protein TusA family
A2I66_RS05005	COG2391	methyltransferase activity
A2I66_RS05010	COG1621	beta-fructofuranosidase activity
A2I66_RS05015	COG3279	Response regulator of the LytR AlgR family
A2I66_RS05030	COG4512	PFAM Accessory gene regulator B
A2I66_RS05050	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A2I66_RS05055	COG0459	protein refolding
A2I66_RS05085	COG1725	Transcriptional regulator
A2I66_RS05090	COG1131	(ABC) transporter
A2I66_RS05100	COG1131	(ABC) transporter
A2I66_RS05145	COG2706	6-phosphogluconolactonase activity
A2I66_RS05160	COG1335	isochorismatase
A2I66_RS05165	COG1227	inorganic diphosphatase activity
A2I66_RS05170	COG1012	belongs to the aldehyde dehydrogenase family
A2I66_RS05180	COG0077	Prephenate dehydratase
A2I66_RS05190	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A2I66_RS05195	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A2I66_RS05200	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
A2I66_RS05210	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A2I66_RS05215	COG4496	protein, YerC YecD
A2I66_RS05220	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
A2I66_RS05230	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A2I66_RS05235	COG4851	CamS sex pheromone cAM373 precursor
A2I66_RS05245	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A2I66_RS05250	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A2I66_RS05255	COG0154	amidase activity
A2I66_RS05260	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A2I66_RS05265	COG1597	lipid kinase activity
A2I66_RS05280	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A2I66_RS05300	COG4129	membrane
A2I66_RS05325	COG2197	response regulator
A2I66_RS05330	COG0288	reversible hydration of carbon dioxide
A2I66_RS05335	COG1295	ribonuclease BN
A2I66_RS05350	COG4840	Belongs to the UPF0435 family
A2I66_RS05355	COG2309	aminopeptidase activity
A2I66_RS05360	COG1607	acyl-coa hydrolase
A2I66_RS05365	COG0535	radical SAM domain protein
A2I66_RS05380	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A2I66_RS05385	COG2137	regulation of response to DNA damage stimulus
A2I66_RS05395	COG1134	teichoic acid transport
A2I66_RS05395	COG1388	LysM domain
A2I66_RS05405	COG1988	membrane-bound metal-dependent
A2I66_RS05415	COG3557	Belongs to the UPF0374 family
A2I66_RS05425	COG4129	membrane
A2I66_RS05430	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A2I66_RS05435	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A2I66_RS05445	COG0735	belongs to the Fur family
A2I66_RS05605	COG0765	amino acid transport
A2I66_RS05610	COG1126	abc transporter atp-binding protein
A2I66_RS05615	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A2I66_RS05625	COG0363	glucosamine-6-phosphate deaminase activity
A2I66_RS05635	COG0114	fumarate hydratase activity
A2I66_RS05640	COG0564	pseudouridine synthase activity
A2I66_RS05650	COG2197	response regulator
A2I66_RS05655	COG1301	dicarboxylic acid transport
A2I66_RS05665	COG4399	Belongs to the UPF0754 family
A2I66_RS05670	COG3679	Belongs to the UPF0342 family
A2I66_RS05675	COG0420	3'-5' exonuclease activity
A2I66_RS05685	COG3481	metal-dependent phosphohydrolase, HD sub domain
A2I66_RS05690	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A2I66_RS05705	COG0537	adenosine 5'-monophosphoramidase activity
A2I66_RS05710	COG1131	(ABC) transporter
A2I66_RS05715	COG4473	ABC transporter
A2I66_RS05725	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A2I66_RS05730	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A2I66_RS05735	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
A2I66_RS05745	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A2I66_RS05750	COG0157	Belongs to the NadC ModD family
A2I66_RS05755	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A2I66_RS05770	COG1827	regulation of RNA biosynthetic process
A2I66_RS05775	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A2I66_RS05890	COG0629	single-stranded DNA binding
A2I66_RS06170	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A2I66_RS06180	COG1506	peptidase
A2I66_RS06185	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A2I66_RS06190	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A2I66_RS06205	COG0656	L-ascorbic acid biosynthetic process
A2I66_RS06210	COG1397	ADP-ribosylglycohydrolase
A2I66_RS06215	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A2I66_RS06230	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A2I66_RS06250	COG4193	domain, Protein
A2I66_RS06250	COG3266	domain, Protein
A2I66_RS06250	COG5632	N-Acetylmuramoyl-L-alanine amidase
A2I66_RS06260	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A2I66_RS06260	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A2I66_RS06265	COG0307	riboflavin synthase, alpha
A2I66_RS06270	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A2I66_RS06270	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A2I66_RS06275	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A2I66_RS06280	COG0506	proline dehydrogenase activity
A2I66_RS06285	COG2267	carboxylic ester hydrolase activity
A2I66_RS06290	COG0039	L-malate dehydrogenase activity
A2I66_RS06295	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A2I66_RS06300	COG1242	4 iron, 4 sulfur cluster binding
A2I66_RS06305	COG2814	Major facilitator Superfamily
A2I66_RS06320	COG2081	HI0933 family
A2I66_RS06325	COG2244	polysaccharide biosynthetic process
A2I66_RS06330	COG1187	pseudouridine synthase activity
A2I66_RS06340	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A2I66_RS06350	COG0510	thiamine kinase activity
A2I66_RS06355	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A2I66_RS06360	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A2I66_RS06365	COG5584	Small secreted protein
A2I66_RS06370	COG1363	Peptidase, m42
A2I66_RS06375	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A2I66_RS06380	COG4848	Belongs to the UPF0354 family
A2I66_RS06385	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A2I66_RS06390	COG1674	ftsk spoiiie
A2I66_RS06395	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A2I66_RS06400	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
A2I66_RS06410	COG1605	Chorismate mutase
A2I66_RS06410	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A2I66_RS06415	COG1609	Transcriptional regulator
A2I66_RS06425	COG0454	-acetyltransferase
A2I66_RS06430	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A2I66_RS06435	COG2759	Belongs to the formate--tetrahydrofolate ligase family
A2I66_RS06445	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A2I66_RS06450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A2I66_RS06455	COG0204	Acyl-transferase
A2I66_RS06470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A2I66_RS06475	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A2I66_RS06480	COG1764	response to oxidative stress
A2I66_RS06485	COG0584	glycerophosphoryl diester phosphodiesterase
A2I66_RS06490	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A2I66_RS06495	COG1956	GAF domain-containing protein
A2I66_RS06500	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
A2I66_RS06505	COG1104	cysteine desulfurase activity
A2I66_RS06510	COG0301	tRNA thio-modification
A2I66_RS06520	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A2I66_RS06525	COG0827	DNA restriction-modification system
A2I66_RS06530	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A2I66_RS06535	COG0589	response to stress
A2I66_RS06540	COG0686	Belongs to the AlaDH PNT family
A2I66_RS06545	COG0006	proline dipeptidase activity
A2I66_RS06550	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A2I66_RS06560	COG4109	DRTGG domain
A2I66_RS06565	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A2I66_RS06575	COG0281	malic enzyme
A2I66_RS06580	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A2I66_RS06585	COG0825	malonyl-CoA metabolic process
A2I66_RS06590	COG0205	6-phosphofructokinase activity
A2I66_RS06595	COG0469	pyruvate kinase activity
A2I66_RS06600	COG1113	amino acid transport
A2I66_RS06605	COG0372	Belongs to the citrate synthase family
A2I66_RS06610	COG0538	isocitrate dehydrogenase activity
A2I66_RS06615	COG0745	RESPONSE REGULATOR receiver
A2I66_RS06620	COG5002	protein histidine kinase activity
A2I66_RS06625	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A2I66_RS06625	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A2I66_RS06635	COG0237	dephospho-CoA kinase activity
A2I66_RS06645	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A2I66_RS06650	COG3611	Membrane attachment protein
A2I66_RS06655	COG1484	DNA-dependent DNA replication
A2I66_RS06660	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A2I66_RS06665	COG0833	amino acid
A2I66_RS06670	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A2I66_RS06675	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A2I66_RS06680	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A2I66_RS06685	COG4112	unkown
A2I66_RS06695	COG0544	peptidyl-prolyl cis-trans isomerase activity
A2I66_RS06700	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A2I66_RS06705	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A2I66_RS06710	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A2I66_RS06715	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A2I66_RS06720	COG0181	hydroxymethylbilane synthase activity
A2I66_RS06735	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A2I66_RS06740	COG3180	Ammonia monooxygenase
A2I66_RS06745	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
A2I66_RS06750	COG2818	Glycosylase
A2I66_RS06755	COG0525	valine-tRNA ligase activity
A2I66_RS06760	COG0285	dihydrofolate synthase activity
A2I66_RS06770	COG2003	Belongs to the UPF0758 family
A2I66_RS06790	COG1792	Involved in formation and maintenance of cell shape
A2I66_RS06800	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A2I66_RS06805	COG2868	ribosomal protein
A2I66_RS06810	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A2I66_RS06815	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A2I66_RS06820	COG4492	Belongs to the UPF0735 family
A2I66_RS06825	COG0632	four-way junction helicase activity
A2I66_RS06830	COG2255	four-way junction helicase activity
A2I66_RS06835	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A2I66_RS06840	COG0343	queuine tRNA-ribosyltransferase activity
A2I66_RS06845	COG1862	Preprotein translocase
A2I66_RS06850	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A2I66_RS06850	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A2I66_RS06855	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A2I66_RS06855	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A2I66_RS06860	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A2I66_RS06870	COG1490	D-aminoacyl-tRNA deacylase activity
A2I66_RS06875	COG0860	N-Acetylmuramoyl-L-alanine amidase
A2I66_RS06880	COG0124	histidyl-tRNA synthetase
A2I66_RS06885	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A2I66_RS06895	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A2I66_RS06900	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A2I66_RS06905	COG1959	2 iron, 2 sulfur cluster binding
A2I66_RS06915	COG3237	CsbD-like
A2I66_RS06920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A2I66_RS06925	COG1104	cysteine desulfurase activity
A2I66_RS06930	COG0482	sulfurtransferase activity
A2I66_RS06940	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A2I66_RS06945	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A2I66_RS06950	COG4472	Bacterial protein of unknown function (DUF965)
A2I66_RS06955	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A2I66_RS06960	COG3906	Belongs to the UPF0473 family
A2I66_RS06965	COG4122	O-methyltransferase activity
A2I66_RS06970	COG0826	peptidase U32
A2I66_RS06975	COG0826	peptidase U32
A2I66_RS06980	COG0572	uridine kinase
A2I66_RS06985	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A2I66_RS06990	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A2I66_RS06995	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
A2I66_RS07005	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A2I66_RS07010	COG1534	Rna-binding protein
A2I66_RS07015	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A2I66_RS07020	COG1713	HD superfamily hydrolase involved in NAD metabolism
A2I66_RS07025	COG0799	negative regulation of ribosome biogenesis
A2I66_RS07030	COG2226	methyltransferase
A2I66_RS07035	COG1555	photosystem II stabilization
A2I66_RS07035	COG1596	polysaccharide export
A2I66_RS07040	COG2131	deaminase
A2I66_RS07050	COG2333	competence protein COMEC
A2I66_RS07050	COG0658	competence protein
A2I66_RS07055	COG1466	dna polymerase III delta subunit
A2I66_RS07060	COG0268	Binds directly to 16S ribosomal RNA
A2I66_RS07065	COG0481	GTPase activity
A2I66_RS07070	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A2I66_RS07075	COG1420	regulation of RNA biosynthetic process
A2I66_RS07080	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A2I66_RS07085	COG0443	Heat shock 70 kDa protein
A2I66_RS07090	COG0484	heat shock protein binding
A2I66_RS07095	COG2264	protein methyltransferase activity
A2I66_RS07100	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A2I66_RS07105	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A2I66_RS07120	COG4864	UPF0365 protein
A2I66_RS07130	COG1702	phosphate starvation-inducible protein PhoH
A2I66_RS07135	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A2I66_RS07140	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A2I66_RS07150	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A2I66_RS07155	COG1381	Involved in DNA repair and RecF pathway recombination
A2I66_RS07160	COG0423	glycine-tRNA ligase activity
A2I66_RS07165	COG0517	IMP dehydrogenase activity
A2I66_RS07170	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A2I66_RS07180	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A2I66_RS07185	COG2384	SAM-dependent methyltransferase
A2I66_RS07195	COG0513	Belongs to the DEAD box helicase family
A2I66_RS07200	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A2I66_RS07205	COG1121	(ABC) transporter
A2I66_RS07210	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A2I66_RS07225	COG0768	penicillin binding
A2I66_RS07230	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A2I66_RS07240	COG4483	Protein conserved in bacteria
A2I66_RS07245	COG1940	carbohydrate kinase activity
A2I66_RS07250	COG0011	TIGRFAM Protein of
A2I66_RS07255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A2I66_RS07260	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A2I66_RS07265	COG1459	type II secretion system
A2I66_RS07295	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A2I66_RS07300	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A2I66_RS07305	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A2I66_RS07310	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A2I66_RS07315	COG0095	Lipoate-protein ligase
A2I66_RS07330	COG0006	proline dipeptidase activity
A2I66_RS07335	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A2I66_RS07340	COG0511	ligase activity, forming carbon-carbon bonds
A2I66_RS07345	COG0439	Biotin carboxylase
A2I66_RS07355	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A2I66_RS07360	COG1570	exodeoxyribonuclease VII activity
A2I66_RS07365	COG1722	exodeoxyribonuclease VII activity
A2I66_RS07375	COG1438	arginine binding
A2I66_RS07380	COG0497	DNA recombination
A2I66_RS07385	COG0280	phosphate acetyltransferase
A2I66_RS07390	COG3426	butyrate kinase activity
A2I66_RS07395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A2I66_RS07400	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A2I66_RS07405	COG0022	dehydrogenase e1 component
A2I66_RS07410	COG0508	dehydrogenase complex catalyzes the overall conversion of
A2I66_RS07420	COG4129	membrane
A2I66_RS07425	COG2195	Cleaves the N-terminal amino acid of tripeptides
A2I66_RS07430	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A2I66_RS07440	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A2I66_RS07445	COG1234	tRNA 3'-trailer cleavage
A2I66_RS07450	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A2I66_RS07460	COG0667	Aldo Keto reductase
A2I66_RS07465	COG0494	nUDIX hydrolase
A2I66_RS07470	COG0735	belongs to the Fur family
A2I66_RS07475	COG4974	Belongs to the 'phage' integrase family
A2I66_RS07485	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A2I66_RS07490	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A2I66_RS07495	COG1187	pseudouridine synthase activity
A2I66_RS07500	COG0745	RESPONSE REGULATOR receiver
A2I66_RS07515	COG1141	Ferredoxin
A2I66_RS07525	COG0514	ATP-dependent DNA helicase (RecQ)
A2I66_RS07530	COG1388	LysM domain
A2I66_RS07530	COG1388	LysM domain
A2I66_RS07535	COG0492	ferredoxin-NADP+ reductase activity
A2I66_RS07545	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A2I66_RS07550	COG0539	negative regulation of cytoplasmic translation
A2I66_RS07555	COG1160	GTP binding
A2I66_RS07560	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A2I66_RS07575	COG2226	methyltransferase
A2I66_RS07580	COG0142	geranyltranstransferase activity
A2I66_RS07585	COG0105	UTP biosynthetic process
A2I66_RS07590	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A2I66_RS07595	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A2I66_RS07600	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A2I66_RS07610	COG5582	Belongs to the UPF0302 family
A2I66_RS07615	COG4347	Protein of unknown function (DUF1405)
A2I66_RS07620	COG2738	Putative neutral zinc metallopeptidase
A2I66_RS07625	COG1694	Mazg nucleotide pyrophosphohydrolase
A2I66_RS07630	COG0438	transferase activity, transferring glycosyl groups
A2I66_RS07635	COG0617	tRNA 3'-terminal CCA addition
A2I66_RS07645	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A2I66_RS07645	COG1199	ATP-dependent helicase activity
A2I66_RS07650	COG0017	Asparaginyl-tRNA synthetase
A2I66_RS07655	COG3935	DnaD domain protein
A2I66_RS07660	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A2I66_RS07670	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A2I66_RS07670	COG4499	WXG100 protein secretion system (Wss), protein YukC
A2I66_RS07675	COG3331	DNA recombination
A2I66_RS07685	COG4474	Belongs to the UPF0398 family
A2I66_RS07690	COG3599	regulation of cell shape
A2I66_RS07700	COG0116	Belongs to the methyltransferase superfamily
A2I66_RS07705	COG2962	Rard protein
A2I66_RS07710	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A2I66_RS07715	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A2I66_RS07720	COG0328	RNA-DNA hybrid ribonuclease activity
A2I66_RS07725	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A2I66_RS07735	COG1413	lyase activity
A2I66_RS07765	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A2I66_RS07770	COG2190	(PTS) system
A2I66_RS07775	COG4479	Belongs to the UPF0346 family
A2I66_RS07780	COG0793	Belongs to the peptidase S41A family
A2I66_RS07790	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A2I66_RS07795	COG0671	phosphoesterase, PA-phosphatase related
A2I66_RS07800	COG0745	RESPONSE REGULATOR receiver
A2I66_RS07805	COG5002	protein histidine kinase activity
A2I66_RS07810	COG0567	Dehydrogenase, E1 component
A2I66_RS07835	COG0714	Associated with various cellular activities
A2I66_RS07840	COG4548	von Willebrand factor, type A
A2I66_RS07845	COG1114	Component of the transport system for branched-chain amino acids
A2I66_RS07850	COG1597	lipid kinase activity
A2I66_RS07855	COG3853	Toxic anion resistance protein (TelA)
A2I66_RS07890	COG1473	amidohydrolase
A2I66_RS07895	COG2171	N-acyltransferase activity
A2I66_RS07900	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A2I66_RS07905	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A2I66_RS07910	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A2I66_RS07915	COG0527	aspartate kinase activity
A2I66_RS07920	COG0488	(ABC) transporter
A2I66_RS07925	COG2996	Protein conserved in bacteria
A2I66_RS07930	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A2I66_RS07935	COG0573	inorganic phosphate transmembrane transporter activity
A2I66_RS07940	COG0581	inorganic phosphate transmembrane transporter activity
A2I66_RS07945	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A2I66_RS07950	COG0704	Plays a role in the regulation of phosphate uptake
A2I66_RS07955	COG1164	Oligoendopeptidase f
A2I66_RS07965	COG0747	negative chemotaxis
A2I66_RS07995	COG2348	transferase activity, transferring amino-acyl groups
A2I66_RS08000	COG2348	transferase activity, transferring amino-acyl groups
A2I66_RS08005	COG0159	tryptophan synthase activity
A2I66_RS08015	COG0135	phosphoribosylanthranilate isomerase activity
A2I66_RS08020	COG0134	indole-3-glycerol-phosphate synthase activity
A2I66_RS08025	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A2I66_RS08035	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A2I66_RS08040	COG1363	Peptidase, m42
A2I66_RS08045	COG0287	Prephenate dehydrogenase
A2I66_RS08050	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A2I66_RS08085	COG0628	permease
A2I66_RS08090	COG1263	PTS System
A2I66_RS08090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A2I66_RS08090	COG2190	(PTS) system
A2I66_RS08095	COG3711	transcriptional antiterminator
A2I66_RS08100	COG1115	amino acid carrier protein
A2I66_RS08105	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A2I66_RS08110	COG0187	DNA topoisomerase II activity
A2I66_RS08115	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A2I66_RS08120	COG4841	protein insertion into membrane
A2I66_RS08125	COG0824	Thioesterase
A2I66_RS08130	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A2I66_RS08135	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A2I66_RS08140	COG1970	mechanosensitive ion channel activity
A2I66_RS08150	COG0420	3'-5' exonuclease activity
A2I66_RS08155	COG4846	Membrane protein involved in cytochrome C biogenesis
A2I66_RS08160	COG3763	UPF0154 protein
A2I66_RS08165	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A2I66_RS08170	COG4224	UPF0291 protein
A2I66_RS08180	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A2I66_RS08185	COG2340	Cysteine-rich secretory protein family
A2I66_RS08190	COG0516	GMP reductase activity
A2I66_RS08195	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A2I66_RS08205	COG0833	amino acid
A2I66_RS08215	COG0561	phosphatase activity
A2I66_RS08220	COG0083	homoserine kinase activity
A2I66_RS08225	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A2I66_RS08230	COG0460	homoserine dehydrogenase
A2I66_RS08235	COG0527	aspartate kinase activity
A2I66_RS08260	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
A2I66_RS08265	COG1525	nuclease
A2I66_RS08275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A2I66_RS08285	COG0789	Transcriptional regulator
A2I66_RS08295	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
A2I66_RS08300	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A2I66_RS08310	COG1923	regulation of RNA biosynthetic process
A2I66_RS08315	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A2I66_RS08320	COG2267	carboxylic ester hydrolase activity
A2I66_RS08325	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A2I66_RS08330	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A2I66_RS08335	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A2I66_RS08345	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A2I66_RS08350	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A2I66_RS08355	COG0584	glycerophosphoryl diester phosphodiesterase
A2I66_RS08365	COG4550	Control of competence regulator ComK, YlbF/YmcA
A2I66_RS08370	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A2I66_RS08375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A2I66_RS08385	COG4608	Belongs to the ABC transporter superfamily
A2I66_RS08390	COG0444	Belongs to the ABC transporter superfamily
A2I66_RS08410	COG1013	pyruvate-flavodoxin oxidoreductase activity
A2I66_RS08415	COG0674	pyruvate-flavodoxin oxidoreductase activity
A2I66_RS08415	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A2I66_RS08420	COG1692	metallophosphoesterase
A2I66_RS08430	COG0583	DNA-binding transcription factor activity
A2I66_RS08440	COG1418	mRNA catabolic process
A2I66_RS08445	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A2I66_RS08450	COG1546	Belongs to the CinA family
A2I66_RS08450	COG1058	Belongs to the CinA family
A2I66_RS08470	COG0300	oxidoreductase activity
A2I66_RS08475	COG0612	Peptidase, M16
A2I66_RS08480	COG0612	Peptidase, M16
A2I66_RS08485	COG2188	Transcriptional regulator
A2I66_RS08495	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A2I66_RS08500	COG1185	polyribonucleotide nucleotidyltransferase activity
A2I66_RS08505	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A2I66_RS08510	COG0196	riboflavin kinase activity
A2I66_RS08515	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A2I66_RS08520	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A2I66_RS08530	COG0584	glycerophosphoryl diester phosphodiesterase
A2I66_RS08545	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A2I66_RS08550	COG1358	cellular component organization or biogenesis
A2I66_RS08555	COG2740	Nucleic-acid-binding protein implicated in transcription termination
A2I66_RS08560	COG0195	Participates in both transcription termination and antitermination
A2I66_RS08565	COG0779	Required for maturation of 30S ribosomal subunits
A2I66_RS08570	COG2176	DNA-directed DNA polymerase activity
A2I66_RS08575	COG0442	prolyl-tRNA aminoacylation
A2I66_RS08585	COG4589	Belongs to the CDS family
A2I66_RS08595	COG0233	cytoplasmic translational termination
A2I66_RS08600	COG0528	UMP kinase activity
A2I66_RS08605	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A2I66_RS08610	COG0052	Belongs to the universal ribosomal protein uS2 family
A2I66_RS08615	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
A2I66_RS08620	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A2I66_RS08625	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A2I66_RS08630	COG4974	Belongs to the 'phage' integrase family
A2I66_RS08635	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
A2I66_RS08640	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A2I66_RS08650	COG0045	succinate-CoA ligase (ADP-forming) activity
A2I66_RS08655	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A2I66_RS08680	COG4149	molybdate abc transporter
A2I66_RS08690	COG1349	DNA-binding transcription factor activity
A2I66_RS08705	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
A2I66_RS08710	COG4485	Bacterial membrane protein, YfhO
A2I66_RS08740	COG0335	large ribosomal subunit rRNA binding
A2I66_RS08745	COG0336	Belongs to the RNA methyltransferase TrmD family
A2I66_RS08750	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A2I66_RS08755	COG0228	four-way junction DNA binding
A2I66_RS08765	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A2I66_RS08770	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
A2I66_RS08775	COG0552	protein localization to endoplasmic reticulum
A2I66_RS08780	COG1196	nuclear chromosome segregation
A2I66_RS08785	COG0571	ribonuclease III activity
A2I66_RS08790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A2I66_RS08805	COG0416	fatty acid biosynthetic process
A2I66_RS08810	COG1349	DNA-binding transcription factor activity
A2I66_RS08820	COG1760	l-serine dehydratase
A2I66_RS08825	COG1760	l-serine dehydratase
A2I66_RS08830	COG1461	Dihydroxyacetone kinase
A2I66_RS08835	COG1302	Protein conserved in bacteria
A2I66_RS08840	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A2I66_RS08855	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A2I66_RS08860	COG1162	GTPase activity
A2I66_RS08870	COG0631	protein serine/threonine phosphatase activity
A2I66_RS08875	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A2I66_RS08880	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A2I66_RS08880	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A2I66_RS08885	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A2I66_RS08910	COG2910	NAD(P)H-binding
A2I66_RS08915	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A2I66_RS08920	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A2I66_RS08930	COG1758	RNA polymerase activity
A2I66_RS08935	COG0194	GDP metabolic process
A2I66_RS08965	COG0284	orotidine-5'-phosphate decarboxylase activity
A2I66_RS08970	COG0167	dihydroorotate dehydrogenase activity
A2I66_RS08975	COG0543	2 iron, 2 sulfur cluster binding
A2I66_RS08980	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A2I66_RS08985	COG0505	Belongs to the CarA family
A2I66_RS08995	COG0540	Belongs to the ATCase OTCase family
A2I66_RS09000	COG2233	PERMEase
A2I66_RS09005	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A2I66_RS09010	COG0564	pseudouridine synthase activity
A2I66_RS09015	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A2I66_RS09020	COG3942	CHAP domain
A2I66_RS09030	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A2I66_RS09035	COG3599	regulation of cell shape
A2I66_RS09045	COG0762	integral membrane protein
A2I66_RS09050	COG1799	cell septum assembly
A2I66_RS09055	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A2I66_RS09060	COG1496	oxidoreductase activity
A2I66_RS09070	COG0849	cell division
A2I66_RS09075	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A2I66_RS09080	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A2I66_RS09085	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A2I66_RS09090	COG0768	penicillin binding
A2I66_RS09095	COG4839	cell division protein FtsL
A2I66_RS09100	COG0275	rRNA processing
A2I66_RS09105	COG2001	Belongs to the MraZ family
A2I66_RS09110	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
A2I66_RS09115	COG0454	-acetyltransferase
A2I66_RS09120	COG1011	Hydrolase
A2I66_RS09185	COG2153	protein acetylation
A2I66_RS09215	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A2I66_RS09230	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A2I66_RS09235	COG1053	succinate dehydrogenase
A2I66_RS09240	COG2009	succinate dehydrogenase
A2I66_RS09245	COG0322	excinuclease ABC activity
A2I66_RS09250	COG3118	belongs to the thioredoxin family
A2I66_RS09255	COG1193	negative regulation of DNA recombination
A2I66_RS09260	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A2I66_RS09260	COG1796	DNA polymerase
A2I66_RS09275	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A2I66_RS09280	COG0072	phenylalanine-tRNA ligase activity
A2I66_RS09280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A2I66_RS09285	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A2I66_RS09290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A2I66_RS09295	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A2I66_RS09305	COG1323	Belongs to the UPF0348 family
A2I66_RS09315	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A2I66_RS09320	COG0742	ribosomal rna small subunit methyltransferase
A2I66_RS09330	COG4471	UPF0298 protein
A2I66_RS09335	COG0584	glycerophosphoryl diester phosphodiesterase
A2I66_RS09340	COG3679	Belongs to the UPF0342 family
A2I66_RS09355	COG0109	protoheme IX farnesyltransferase activity
A2I66_RS09360	COG1612	heme a metabolic process
A2I66_RS09370	COG0772	Belongs to the SEDS family
A2I66_RS09375	COG4838	Belongs to the UPF0358 family
A2I66_RS09380	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A2I66_RS09390	COG1217	gtp-binding protein TYPA
A2I66_RS09400	COG0483	inositol monophosphate 1-phosphatase activity
A2I66_RS09405	COG4493	Belongs to the UPF0637 family
A2I66_RS09410	COG1914	H( )-stimulated, divalent metal cation uptake system
A2I66_RS09430	COG1177	transmembrane transport
A2I66_RS09435	COG1176	ABC-type spermidine putrescine transport system, permease component I
A2I66_RS09440	COG3842	ATPase activity
A2I66_RS09450	COG4476	Belongs to the UPF0223 family
A2I66_RS09465	COG0022	dehydrogenase e1 component
A2I66_RS09480	COG0242	peptide deformylase activity
A2I66_RS09490	COG5503	Protein of unknown function (DUF1447)
A2I66_RS09500	COG1733	regulation of RNA biosynthetic process
A2I66_RS09505	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
A2I66_RS09515	COG0569	domain protein
A2I66_RS09520	COG1294	oxidase, subunit
A2I66_RS09525	COG1271	oxidase subunit
A2I66_RS09535	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A2I66_RS09550	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A2I66_RS09565	COG1122	ATPase activity
A2I66_RS09570	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A2I66_RS09580	COG0151	Belongs to the GarS family
A2I66_RS09585	COG0138	bifunctional purine biosynthesis protein purh
A2I66_RS09590	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A2I66_RS09595	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A2I66_RS09600	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A2I66_RS09605	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A2I66_RS09620	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A2I66_RS09625	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A2I66_RS09630	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A2I66_RS09635	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A2I66_RS09640	COG1363	Peptidase, m42
A2I66_RS09645	COG1017	nitric oxide dioxygenase activity
A2I66_RS09645	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A2I66_RS09655	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A2I66_RS09665	COG1845	cytochrome c oxidase, subunit III
A2I66_RS09670	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A2I66_RS09680	COG1349	DNA-binding transcription factor activity
A2I66_RS09690	COG0698	ribose 5-phosphate isomerase
A2I66_RS09695	COG1105	Belongs to the carbohydrate kinase PfkB family
A2I66_RS09715	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A2I66_RS09720	COG2723	6-phospho-beta-galactosidase activity
A2I66_RS09725	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A2I66_RS09725	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A2I66_RS09730	COG1447	Phosphotransferase system cellobiose-specific component IIA
A2I66_RS09745	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A2I66_RS09750	COG1316	TRANSCRIPTIONal
A2I66_RS09775	COG3594	Acyltransferase
A2I66_RS09780	COG0436	Aminotransferase
A2I66_RS09785	COG1846	Transcriptional regulator
A2I66_RS09790	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A2I66_RS09800	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A2I66_RS09805	COG1169	isochorismate synthase
A2I66_RS09810	COG1575	Belongs to the MenA family. Type 1 subfamily
A2I66_RS09820	COG2314	TM2 domain
A2I66_RS09835	COG4873	Protein conserved in bacteria
A2I66_RS09865	COG3177	Filamentation induced by cAMP protein fic
A2I66_RS09880	COG2267	carboxylic ester hydrolase activity
A2I66_RS09890	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A2I66_RS09895	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A2I66_RS09900	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A2I66_RS09905	COG0131	Imidazoleglycerol-phosphate dehydratase
A2I66_RS09915	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A2I66_RS09920	COG0107	imidazoleglycerol-phosphate synthase activity
A2I66_RS09940	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A2I66_RS09945	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A2I66_RS09950	COG0861	Integral membrane protein TerC family
A2I66_RS09955	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A2I66_RS09965	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A2I66_RS09970	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A2I66_RS09975	COG2814	Major facilitator Superfamily
A2I66_RS09985	COG2382	esterase
A2I66_RS09990	COG1115	amino acid carrier protein
A2I66_RS09995	COG0628	permease
A2I66_RS10000	COG2814	Major facilitator Superfamily
A2I66_RS10010	COG0569	domain protein
A2I66_RS10010	COG0475	glutathione-regulated potassium exporter activity
A2I66_RS10015	COG2239	Acts as a magnesium transporter
A2I66_RS10020	COG0564	pseudouridine synthase activity
A2I66_RS10025	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A2I66_RS10030	COG2357	RelA SpoT domain protein
A2I66_RS10040	COG4116	CYTH
A2I66_RS10045	COG2346	COG2346, Truncated hemoglobins
A2I66_RS10070	COG1164	Oligoendopeptidase f
A2I66_RS10075	COG4862	establishment of competence for transformation
A2I66_RS10080	COG1393	Belongs to the ArsC family
A2I66_RS10090	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A2I66_RS10095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A2I66_RS10100	COG4166	transmembrane transport
A2I66_RS10105	COG4608	Belongs to the ABC transporter superfamily
A2I66_RS10110	COG0444	Belongs to the ABC transporter superfamily
A2I66_RS10115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A2I66_RS10120	COG0601	transmembrane transport
A2I66_RS10140	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A2I66_RS10150	COG0542	response to heat
A2I66_RS10160	COG2151	metal-sulfur cluster biosynthetic enzyme
A2I66_RS10165	COG0561	phosphatase activity
A2I66_RS10170	COG0446	pyridine nucleotide-disulphide oxidoreductase
A2I66_RS10180	COG0179	Fumarylacetoacetate (FAA) hydrolase
A2I66_RS10185	COG1074	ATP-dependent DNA helicase activity
A2I66_RS10190	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
A2I66_RS10205	COG0398	Pfam SNARE associated Golgi protein
A2I66_RS10215	COG0137	argininosuccinate synthase activity
A2I66_RS10220	COG0165	Argininosuccinate lyase
A2I66_RS10235	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A2I66_RS10240	COG1012	belongs to the aldehyde dehydrogenase family
A2I66_RS10245	COG1902	pentaerythritol trinitrate reductase activity
A2I66_RS10250	COG1098	S1 RNA binding domain
A2I66_RS10255	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A2I66_RS10265	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A2I66_RS10275	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A2I66_RS10275	COG2111	Na H antiporter
A2I66_RS10280	COG2111	Na H antiporter
A2I66_RS10285	COG1006	Multisubunit Na H antiporter MnhC subunit
A2I66_RS10290	COG0651	ATP synthesis coupled electron transport
A2I66_RS10295	COG1863	multisubunit Na H antiporter MnhE subunit
A2I66_RS10300	COG2212	antiporter activity
A2I66_RS10315	COG2050	protein possibly involved in aromatic compounds catabolism
A2I66_RS10320	COG2056	Na+-H+ antiporter family
A2I66_RS10325	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A2I66_RS10330	COG1252	NADH dehydrogenase
A2I66_RS10335	COG0316	Belongs to the HesB IscA family
A2I66_RS10340	COG4844	belongs to the
A2I66_RS10345	COG1252	NADH dehydrogenase
A2I66_RS10350	COG0519	Catalyzes the synthesis of GMP from XMP
A2I66_RS10355	COG4837	Protein of unknown function (DUF1462)
A2I66_RS10360	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A2I66_RS10365	COG0789	Transcriptional regulator
A2I66_RS10370	COG2217	Heavy metal translocating P-type atpase
A2I66_RS10375	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
A2I66_RS10380	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A2I66_RS10385	COG1696	Membrane protein involved in D-alanine export
A2I66_RS10390	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A2I66_RS10400	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A2I66_RS10405	COG0647	UMP catabolic process
A2I66_RS10410	COG2445	Protein of unknown function DUF86
A2I66_RS10420	COG4470	Protein conserved in bacteria
A2I66_RS10425	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A2I66_RS10430	COG0737	Belongs to the 5'-nucleotidase family
A2I66_RS10435	COG0730	response to heat
A2I66_RS10440	COG1801	Protein of unknown function DUF72
A2I66_RS10450	COG4536	flavin adenine dinucleotide binding
A2I66_RS10470	COG5632	N-Acetylmuramoyl-L-alanine amidase
A2I66_RS10470	COG1388	LysM domain
A2I66_RS10495	COG4632	Exopolysaccharide biosynthesis protein
A2I66_RS10495	COG5434	Belongs to the glycosyl hydrolase 28 family
A2I66_RS10570	COG0740	serine-type endopeptidase activity
A2I66_RS10620	COG0756	dUTP diphosphatase activity
A2I66_RS10670	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A2I66_RS10740	COG3617	BRO family, N-terminal domain
A2I66_RS10790	COG4974	Belongs to the 'phage' integrase family
A2I66_RS10795	COG0719	Fe-S assembly protein
A2I66_RS10800	COG0822	iron-sulfur transferase activity
A2I66_RS10805	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A2I66_RS10810	COG0719	Fe-S assembly protein
A2I66_RS10815	COG0396	ATPase activity
A2I66_RS10820	COG1464	Belongs to the NlpA lipoprotein family
A2I66_RS10825	COG2011	ABC-type metal ion transport system permease component
A2I66_RS10830	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A2I66_RS10840	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
A2I66_RS10845	COG0509	glycine decarboxylation via glycine cleavage system
A2I66_RS10850	COG1393	Belongs to the ArsC family
A2I66_RS10855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A2I66_RS10865	COG0710	3-dehydroquinate dehydratase activity
A2I66_RS10895	COG1704	LemA family
A2I66_RS10900	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A2I66_RS10920	COG1278	Cold shock
A2I66_RS10935	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A2I66_RS10950	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A2I66_RS10955	COG0557	exoribonuclease II activity
A2I66_RS10960	COG1647	Serine aminopeptidase, S33
A2I66_RS10965	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A2I66_RS10975	COG0148	phosphopyruvate hydratase activity
A2I66_RS10980	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A2I66_RS10985	COG0149	triose-phosphate isomerase activity
A2I66_RS10990	COG0126	phosphoglycerate kinase activity
A2I66_RS10995	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A2I66_RS11035	COG1114	Component of the transport system for branched-chain amino acids
A2I66_RS11040	COG2814	Major facilitator Superfamily
A2I66_RS11045	COG1481	regulation of sporulation
A2I66_RS11050	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A2I66_RS11055	COG1660	Displays ATPase and GTPase activities
A2I66_RS11070	COG0110	maltose O-acetyltransferase activity
A2I66_RS11075	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A2I66_RS11080	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
A2I66_RS11105	COG3942	CHAP domain
A2I66_RS11115	COG0653	protein targeting
A2I66_RS11120	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A2I66_RS11130	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
A2I66_RS11140	COG1739	Uncharacterized protein family UPF0029
A2I66_RS11145	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A2I66_RS11150	COG2199	diguanylate cyclase activity
A2I66_RS11165	COG2195	Cleaves the N-terminal amino acid of tripeptides
A2I66_RS11170	COG1929	Belongs to the glycerate kinase type-1 family
A2I66_RS11190	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A2I66_RS11205	COG4607	ABC-type enterochelin transport system periplasmic component
A2I66_RS11210	COG4604	ABC transporter, ATP-binding protein
A2I66_RS11215	COG4605	iron ion homeostasis
A2I66_RS11220	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A2I66_RS11225	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A2I66_RS11230	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A2I66_RS11235	COG1780	Probably involved in ribonucleotide reductase function
A2I66_RS11240	COG0697	spore germination
A2I66_RS11245	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A2I66_RS11250	COG3104	oligopeptide transport
A2I66_RS11255	COG3104	oligopeptide transport
A2I66_RS11265	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A2I66_RS11270	COG1174	glycine betaine transport
A2I66_RS11280	COG0514	ATP-dependent DNA helicase (RecQ)
A2I66_RS11285	COG0488	(ABC) transporter
A2I66_RS11290	COG1368	sulfuric ester hydrolase activity
A2I66_RS11300	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A2I66_RS11315	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A2I66_RS11315	COG0512	Glutamine amidotransferase of anthranilate synthase
A2I66_RS11320	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A2I66_RS11325	COG0720	synthase
A2I66_RS11330	COG0602	queuosine metabolic process
A2I66_RS11345	COG0656	L-ascorbic acid biosynthetic process
A2I66_RS11350	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
A2I66_RS11375	COG1253	flavin adenine dinucleotide binding
A2I66_RS11380	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A2I66_RS11380	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A2I66_RS11380	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A2I66_RS11385	COG1105	Belongs to the carbohydrate kinase PfkB family
A2I66_RS11390	COG1349	DNA-binding transcription factor activity
A2I66_RS11395	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A2I66_RS11410	COG1464	Belongs to the NlpA lipoprotein family
A2I66_RS11430	COG0471	metal ion transport
A2I66_RS11435	COG0039	L-malate dehydrogenase activity
A2I66_RS11440	COG0586	Pfam SNARE associated Golgi protein
A2I66_RS11450	COG4989	oxidoreductase activity
A2I66_RS11455	COG0523	cobalamin synthesis protein
A2I66_RS11465	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A2I66_RS11470	COG4988	ABC transporter
A2I66_RS11475	COG1968	undecaprenyl-diphosphatase activity
A2I66_RS11485	COG1671	Belongs to the UPF0178 family
A2I66_RS11515	COG2839	Protein conserved in bacteria
A2I66_RS11520	COG2814	Major facilitator Superfamily
A2I66_RS11525	COG0583	DNA-binding transcription factor activity
A2I66_RS11540	COG0217	transcriptional regulatory protein
A2I66_RS11565	COG3942	CHAP domain
A2I66_RS11565	COG1388	LysM domain
A2I66_RS11570	COG1733	regulation of RNA biosynthetic process
A2I66_RS11580	COG0656	L-ascorbic acid biosynthetic process
A2I66_RS11585	COG0306	phosphate transporter
A2I66_RS11590	COG1392	Phosphate transport regulator
A2I66_RS11595	COG0577	efflux transmembrane transporter activity
A2I66_RS11610	COG2205	protein histidine kinase activity
A2I66_RS11615	COG0745	RESPONSE REGULATOR receiver
A2I66_RS11625	COG0657	acetylesterase activity
A2I66_RS11630	COG3949	Membrane
A2I66_RS11640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A2I66_RS11645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A2I66_RS11650	COG1120	ATPase activity
A2I66_RS11655	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A2I66_RS11660	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A2I66_RS11665	COG1132	(ABC) transporter
A2I66_RS11670	COG1686	Belongs to the peptidase S11 family
A2I66_RS11675	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A2I66_RS11685	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A2I66_RS11690	COG1682	transport, permease protein
A2I66_RS11700	COG5609	conserved protein (DUF2294)
A2I66_RS11705	COG3949	Membrane
A2I66_RS11715	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A2I66_RS11720	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
A2I66_RS11725	COG0110	maltose O-acetyltransferase activity
A2I66_RS11735	COG1247	-acetyltransferase
A2I66_RS11740	COG0671	phosphoesterase, PA-phosphatase related
A2I66_RS11755	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A2I66_RS11760	COG0803	Belongs to the bacterial solute-binding protein 9 family
A2I66_RS11765	COG0025	NhaP-type Na H and K H
A2I66_RS11815	COG0546	phosphoglycolate phosphatase activity
A2I66_RS11820	COG4139	cobalamin transport
A2I66_RS11825	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A2I66_RS11830	COG0018	arginyl-trna synthetase
A2I66_RS11840	COG1473	amidohydrolase
A2I66_RS11845	COG4115	mRNA cleavage
A2I66_RS11865	COG1279	arginine transmembrane transporter activity
A2I66_RS11875	COG1078	dGTPase activity
A2I66_RS11880	COG0519	Catalyzes the synthesis of GMP from XMP
A2I66_RS11895	COG4844	belongs to the
A2I66_RS11915	COG0095	Lipoate-protein ligase
A2I66_RS11920	COG0280	phosphate acetyltransferase
A2I66_RS11925	COG3253	May function as heme-dependent peroxidase
A2I66_RS11930	COG2966	Psort location CytoplasmicMembrane, score
A2I66_RS11945	COG0586	Pfam SNARE associated Golgi protein
A2I66_RS11950	COG0531	amino acid
A2I66_RS11955	COG2363	Small membrane protein
A2I66_RS11965	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A2I66_RS11975	COG0477	Major facilitator Superfamily
A2I66_RS11980	COG1469	GTP cyclohydrolase I activity
A2I66_RS11985	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A2I66_RS11990	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A2I66_RS11995	COG0363	glucosamine-6-phosphate deaminase activity
A2I66_RS12000	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
A2I66_RS12005	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A2I66_RS12010	COG0431	NADPH-dependent FMN reductase
A2I66_RS12015	COG0561	phosphatase activity
A2I66_RS12025	COG1428	Deoxynucleoside kinase
A2I66_RS12030	COG1428	Deoxynucleoside kinase
A2I66_RS12035	COG0561	phosphatase activity
A2I66_RS12045	COG0546	phosphoglycolate phosphatase activity
A2I66_RS12050	COG2832	Protein of unknown function (DUF454)
A2I66_RS12055	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A2I66_RS12060	COG1619	proteins homologs of microcin C7 resistance protein MccF
A2I66_RS12080	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
A2I66_RS12090	COG1473	amidohydrolase
A2I66_RS12095	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A2I66_RS12100	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A2I66_RS12105	COG0049	tRNA binding
A2I66_RS12110	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A2I66_RS12130	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A2I66_RS12135	COG0085	RNA polymerase activity
A2I66_RS12140	COG2813	Specifically methylates the guanine in position
A2I66_RS12150	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A2I66_RS12155	COG0081	regulation of translation
A2I66_RS12160	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A2I66_RS12165	COG0250	Participates in transcription elongation, termination and antitermination
A2I66_RS12170	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A2I66_RS12175	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A2I66_RS12190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A2I66_RS12195	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
A2I66_RS12200	COG0215	cysteine-tRNA ligase activity
A2I66_RS12205	COG1045	serine acetyltransferase
A2I66_RS12210	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A2I66_RS12215	COG4956	integral membrane protein (PIN domain superfamily)
A2I66_RS12220	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A2I66_RS12225	COG0542	response to heat
A2I66_RS12230	COG3869	Catalyzes the specific phosphorylation of arginine residues in
A2I66_RS12245	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A2I66_RS12260	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
A2I66_RS12265	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
A2I66_RS12270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A2I66_RS12280	COG2814	Major facilitator Superfamily
A2I66_RS12365	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A2I66_RS12370	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A2I66_RS12375	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A2I66_RS12380	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A2I66_RS12395	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A2I66_RS12400	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A2I66_RS12415	COG1098	S1 RNA binding domain
A2I66_RS12425	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A2I66_RS12430	COG3956	TIGRFAM MazG family protein
A2I66_RS12435	COG2244	polysaccharide biosynthetic process
A2I66_RS12440	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A2I66_RS12445	COG0193	aminoacyl-tRNA hydrolase activity
A2I66_RS12450	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A2I66_RS12460	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A2I66_RS12465	COG2088	sporulation resulting in formation of a cellular spore
A2I66_RS12470	COG0251	oxidation-reduction process
A2I66_RS12475	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A2I66_RS12485	COG4466	Protein conserved in bacteria
A2I66_RS12490	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A2I66_RS12495	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
A2I66_RS12500	COG0084	hydrolase, TatD family'
A2I66_RS12505	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A2I66_RS12505	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A2I66_RS12515	COG4152	abc transporter atp-binding protein
A2I66_RS12545	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A2I66_RS12550	COG2827	Endonuclease containing a URI domain
A2I66_RS12555	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A2I66_RS12565	COG1774	PSP1 C-terminal conserved region
A2I66_RS12570	COG0470	DNA polymerase III
A2I66_RS12575	COG3870	Protein conserved in bacteria
A2I66_RS12585	COG1982	Orn Lys Arg decarboxylase major
A2I66_RS12605	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A2I66_RS12610	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A2I66_RS12615	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A2I66_RS12630	COG2814	Major facilitator Superfamily
A2I66_RS12635	COG0583	DNA-binding transcription factor activity
A2I66_RS12650	COG0640	Transcriptional regulator
A2I66_RS12655	COG2188	Transcriptional regulator
A2I66_RS12660	COG0366	Alpha amylase catalytic
A2I66_RS12665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A2I66_RS12665	COG1263	PTS System
A2I66_RS12670	COG0346	lactoylglutathione lyase activity
A2I66_RS12680	COG0493	'glutamate synthase
A2I66_RS12685	COG0069	glutamate synthase activity
A2I66_RS12685	COG0067	glutamate synthase
A2I66_RS12685	COG0070	glutamate synthase
A2I66_RS12690	COG0583	DNA-binding transcription factor activity
A2I66_RS12720	COG4841	protein insertion into membrane
A2I66_RS12725	COG0494	nUDIX hydrolase
A2I66_RS12730	COG4841	protein insertion into membrane
A2I66_RS12740	COG0737	Belongs to the 5'-nucleotidase family
A2I66_RS12755	COG3246	L-lysine catabolic process to acetate
A2I66_RS12760	COG1250	3-hydroxyacyl-CoA dehydrogenase
A2I66_RS12770	COG1279	arginine transmembrane transporter activity
A2I66_RS12775	COG0626	cystathionine gamma-synthase activity
A2I66_RS12780	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A2I66_RS12785	COG0733	neurotransmitter:sodium symporter activity
A2I66_RS12795	COG1647	Serine aminopeptidase, S33
A2I66_RS12845	COG0346	lactoylglutathione lyase activity
A2I66_RS12860	COG1695	Transcriptional regulator
A2I66_RS12865	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A2I66_RS12895	COG2046	Belongs to the sulfate adenylyltransferase family
A2I66_RS12900	COG0730	response to heat
A2I66_RS12905	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A2I66_RS12910	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A2I66_RS12915	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A2I66_RS12920	COG0175	sulfate reduction
A2I66_RS12925	COG1132	(ABC) transporter
A2I66_RS12930	COG0488	(ABC) transporter
A2I66_RS12935	COG1216	Glycosyl transferase, family 2
A2I66_RS12955	COG2514	catechol 2,3-dioxygenase activity
A2I66_RS12960	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A2I66_RS12960	COG0519	Catalyzes the synthesis of GMP from XMP
A2I66_RS12965	COG0516	GMP reductase activity
A2I66_RS12965	COG0517	IMP dehydrogenase activity
A2I66_RS12970	COG2233	PERMEase
A2I66_RS12975	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A2I66_RS12995	COG1823	symporter activity
A2I66_RS13000	COG0778	Nitroreductase
A2I66_RS13010	COG0450	alkyl hydroperoxide reductase
A2I66_RS13015	COG3634	alkyl hydroperoxide reductase activity
A2I66_RS13035	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A2I66_RS13040	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A2I66_RS13065	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A2I66_RS13075	COG0360	Binds together with S18 to 16S ribosomal RNA
A2I66_RS13095	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A2I66_RS13120	COG0012	GTP binding
A2I66_RS13125	COG4481	Protein conserved in bacteria
A2I66_RS13130	COG0668	transmembrane transport
A2I66_RS13135	COG1475	DNA binding
A2I66_RS13145	COG0646	methionine synthase
A2I66_RS13145	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A2I66_RS13160	COG0436	Aminotransferase
A2I66_RS13180	COG1475	DNA binding
A2I66_RS13185	COG0357	Ribosomal RNA small subunit methyltransferase G
A2I66_RS13190	COG0445	tRNA wobble uridine modification
A2I66_RS13195	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A2I66_RS13200	COG0594	ribonuclease P activity