locus-tag	class	description
DWB97_RS00160	COG0582	viral genome integration into host DNA
DWB97_RS00170	COG5632	N-Acetylmuramoyl-L-alanine amidase
DWB97_RS00170	COG1388	LysM domain
DWB97_RS00300	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DWB97_RS00305	COG0592	DNA-directed DNA polymerase activity
DWB97_RS00310	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DWB97_RS00325	COG0187	DNA topoisomerase II activity
DWB97_RS00330	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DWB97_RS00335	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DWB97_RS00340	COG2986	histidine ammonia-lyase
DWB97_RS00345	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DWB97_RS00410	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DWB97_RS00420	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DWB97_RS00425	COG4241	membrane
DWB97_RS00430	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
DWB97_RS00435	COG0359	binds to the 23S rRNA
DWB97_RS00440	COG0305	Participates in initiation and elongation during chromosome replication
DWB97_RS00445	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DWB97_RS00465	COG0745	RESPONSE REGULATOR receiver
DWB97_RS00470	COG5002	protein histidine kinase activity
DWB97_RS00475	COG4863	YycH protein
DWB97_RS00485	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DWB97_RS00505	COG2815	serine threonine protein kinase
DWB97_RS00505	COG0515	serine threonine protein kinase
DWB97_RS00520	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DWB97_RS00530	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DWB97_RS00540	COG2205	protein histidine kinase activity
DWB97_RS00545	COG0745	RESPONSE REGULATOR receiver
DWB97_RS00550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWB97_RS00555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWB97_RS00560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DWB97_RS00565	COG2188	Transcriptional regulator
DWB97_RS00570	COG2222	sugar isomerase
DWB97_RS00575	COG3684	Belongs to the aldolase LacD family
DWB97_RS00585	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
DWB97_RS00585	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DWB97_RS00590	COG3715	PTS system
DWB97_RS00595	COG3716	PTS system mannose fructose sorbose family IID component
DWB97_RS00605	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DWB97_RS00610	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
DWB97_RS00615	COG0039	L-malate dehydrogenase activity
DWB97_RS00620	COG1328	CTP reductase activity
DWB97_RS00625	COG0602	queuosine metabolic process
DWB97_RS00630	COG2814	Major facilitator Superfamily
DWB97_RS00675	COG1705	Flagellar rod assembly protein muramidase FlgJ
DWB97_RS00675	COG3942	CHAP domain
DWB97_RS00690	COG4716	Myosin-crossreactive antigen
DWB97_RS00715	COG3655	Transcriptional regulator
DWB97_RS00720	COG2311	Membrane
DWB97_RS00730	COG2188	Transcriptional regulator
DWB97_RS00735	COG0813	purine-nucleoside phosphorylase activity
DWB97_RS00740	COG2814	Major facilitator Superfamily
DWB97_RS00785	COG0415	Belongs to the DNA photolyase family
DWB97_RS00820	COG1174	glycine betaine transport
DWB97_RS00830	COG1174	glycine betaine transport
DWB97_RS00850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DWB97_RS00870	COG2235	arginine
DWB97_RS00875	COG1438	arginine binding
DWB97_RS00880	COG2814	Major facilitator Superfamily
DWB97_RS00890	COG0579	oxidoreductase
DWB97_RS00895	COG1755	Isoprenylcysteine carboxyl methyltransferase
DWB97_RS00900	COG1113	amino acid transport
DWB97_RS00910	COG1473	amidohydrolase
DWB97_RS00915	COG0745	RESPONSE REGULATOR receiver
DWB97_RS00940	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DWB97_RS00950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DWB97_RS00960	COG1335	isochorismatase
DWB97_RS00980	COG1518	maintenance of DNA repeat elements
DWB97_RS00995	COG1914	H( )-stimulated, divalent metal cation uptake system
DWB97_RS01000	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DWB97_RS01005	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DWB97_RS01010	COG0156	8-amino-7-oxononanoate synthase activity
DWB97_RS01020	COG1620	l-lactate permease
DWB97_RS01025	COG3391	amine dehydrogenase activity
DWB97_RS01040	COG1073	alpha beta
DWB97_RS01055	COG0438	transferase activity, transferring glycosyl groups
DWB97_RS01065	COG0384	phenazine biosynthesis protein PhzF
DWB97_RS01070	COG0183	Belongs to the thiolase family
DWB97_RS01075	COG1250	3-hydroxyacyl-CoA dehydrogenase
DWB97_RS01075	COG1024	Enoyl-CoA hydratase
DWB97_RS01080	COG1960	acyl-CoA dehydrogenase activity
DWB97_RS01085	COG0318	PFAM AMP-dependent synthetase and ligase
DWB97_RS01105	COG0563	adenylate kinase activity
DWB97_RS01115	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DWB97_RS01120	COG0730	response to heat
DWB97_RS01125	COG1937	Protein conserved in bacteria
DWB97_RS01130	COG2210	Belongs to the sulfur carrier protein TusA family
DWB97_RS01135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DWB97_RS01140	COG1609	Transcriptional regulator
DWB97_RS01145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DWB97_RS01150	COG1869	D-ribose catabolic process
DWB97_RS01155	COG1129	ABC transporter
DWB97_RS01160	COG1172	Belongs to the binding-protein-dependent transport system permease family
DWB97_RS01165	COG1879	ABC-type sugar transport system periplasmic component
DWB97_RS01170	COG2814	Major facilitator Superfamily
DWB97_RS01175	COG0583	DNA-binding transcription factor activity
DWB97_RS01180	COG2755	lipolytic protein G-D-S-L family
DWB97_RS01180	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DWB97_RS01195	COG3314	Sporulation integral membrane protein YlbJ
DWB97_RS01235	COG2814	Major facilitator Superfamily
DWB97_RS01240	COG1335	isochorismatase
DWB97_RS01285	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DWB97_RS01310	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DWB97_RS01330	COG2814	Major facilitator Superfamily
DWB97_RS01335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DWB97_RS01355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DWB97_RS01365	COG1115	amino acid carrier protein
DWB97_RS01375	COG0668	transmembrane transport
DWB97_RS01390	COG4195	phage-related replication protein
DWB97_RS01410	COG2843	Capsule synthesis protein
DWB97_RS01420	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DWB97_RS01440	COG2205	protein histidine kinase activity
DWB97_RS01445	COG0745	RESPONSE REGULATOR receiver
DWB97_RS01450	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
DWB97_RS01460	COG0586	Pfam SNARE associated Golgi protein
DWB97_RS01465	COG1785	Belongs to the alkaline phosphatase family
DWB97_RS01470	COG1785	Belongs to the alkaline phosphatase family
DWB97_RS01480	COG0494	nUDIX hydrolase
DWB97_RS01485	COG0513	Belongs to the DEAD box helicase family
DWB97_RS01490	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DWB97_RS01510	COG1510	regulation of RNA biosynthetic process
DWB97_RS01515	COG1012	belongs to the aldehyde dehydrogenase family
DWB97_RS01520	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
DWB97_RS01545	COG0107	imidazoleglycerol-phosphate synthase activity
DWB97_RS01565	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DWB97_RS01570	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DWB97_RS01575	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DWB97_RS01605	COG2271	Major facilitator Superfamily
DWB97_RS01610	COG0529	Catalyzes the synthesis of activated sulfate
DWB97_RS01615	COG2046	Belongs to the sulfate adenylyltransferase family
DWB97_RS01620	COG0730	response to heat
DWB97_RS01630	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DWB97_RS01635	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DWB97_RS01640	COG0175	sulfate reduction
DWB97_RS01645	COG2376	Dihydroxyacetone kinase
DWB97_RS01650	COG1461	Dihydroxyacetone kinase
DWB97_RS01665	COG2824	Alkylphosphonate utilization operon protein PhnA
DWB97_RS01670	COG1012	belongs to the aldehyde dehydrogenase family
DWB97_RS01680	COG0596	Alpha beta hydrolase
DWB97_RS01685	COG0789	Transcriptional regulator
DWB97_RS01690	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DWB97_RS01690	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DWB97_RS01690	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DWB97_RS01695	COG1705	Flagellar rod assembly protein muramidase FlgJ
DWB97_RS01695	COG3942	CHAP domain
DWB97_RS01720	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DWB97_RS01725	COG0747	negative chemotaxis
DWB97_RS01750	COG0463	Glycosyl transferase, family 2
DWB97_RS01750	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DWB97_RS01785	COG1263	PTS System
DWB97_RS01785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DWB97_RS01800	COG3001	Fructosamine kinase
DWB97_RS01820	COG1136	(ABC) transporter
DWB97_RS01825	COG1136	(ABC) transporter
DWB97_RS01825	COG0577	efflux transmembrane transporter activity
DWB97_RS01835	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DWB97_RS01845	COG5002	protein histidine kinase activity
DWB97_RS01860	COG1811	Na channel or pump
DWB97_RS01865	COG4413	Urea transporter
DWB97_RS01875	COG0832	Belongs to the urease beta subunit family
DWB97_RS01880	COG0804	urea catabolic process
DWB97_RS01885	COG0717	Belongs to the dCTP deaminase family
DWB97_RS01895	COG0842	Transport permease protein
DWB97_RS01895	COG1129	ABC transporter
DWB97_RS01900	COG0842	Transport permease protein
DWB97_RS01910	COG1114	Component of the transport system for branched-chain amino acids
DWB97_RS01915	COG3189	MarR family transcriptional regulator
DWB97_RS01930	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWB97_RS01935	COG4605	iron ion homeostasis
DWB97_RS01940	COG4604	ABC transporter, ATP-binding protein
DWB97_RS01945	COG4607	ABC-type enterochelin transport system periplasmic component
DWB97_RS01955	COG1846	Transcriptional regulator
DWB97_RS01960	COG0778	Nitroreductase
DWB97_RS01965	COG2357	RelA SpoT domain protein
DWB97_RS01970	COG0739	heme binding
DWB97_RS01980	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DWB97_RS02005	COG2267	carboxylic ester hydrolase activity
DWB97_RS02010	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
DWB97_RS02015	COG2814	Major facilitator Superfamily
DWB97_RS02030	COG1028	Short-chain dehydrogenase reductase Sdr
DWB97_RS02035	COG0753	catalase activity
DWB97_RS02050	COG1349	DNA-binding transcription factor activity
DWB97_RS02060	COG1070	Carbohydrate kinase
DWB97_RS02065	COG2814	Major facilitator Superfamily
DWB97_RS02070	COG0235	Class ii aldolase
DWB97_RS02080	COG1012	belongs to the aldehyde dehydrogenase family
DWB97_RS02090	COG1028	Short-chain dehydrogenase reductase Sdr
DWB97_RS02130	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DWB97_RS02160	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DWB97_RS02165	COG0110	maltose O-acetyltransferase activity
DWB97_RS02170	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DWB97_RS02180	COG0494	nUDIX hydrolase
DWB97_RS02195	COG3835	regulator
DWB97_RS02205	COG3961	Belongs to the TPP enzyme family
DWB97_RS02210	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DWB97_RS02215	COG0512	Glutamine amidotransferase of anthranilate synthase
DWB97_RS02220	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DWB97_RS02225	COG0134	indole-3-glycerol-phosphate synthase activity
DWB97_RS02230	COG0135	phosphoribosylanthranilate isomerase activity
DWB97_RS02235	COG0133	tryptophan synthase activity
DWB97_RS02240	COG0159	tryptophan synthase activity
DWB97_RS02245	COG1011	Hydrolase
DWB97_RS02260	COG1132	(ABC) transporter
DWB97_RS02265	COG1132	(ABC) transporter
DWB97_RS02270	COG0789	Transcriptional regulator
DWB97_RS02275	COG0346	lactoylglutathione lyase activity
DWB97_RS02280	COG3871	stress protein (general stress protein 26)
DWB97_RS02285	COG1115	amino acid carrier protein
DWB97_RS02295	COG2814	Major facilitator Superfamily
DWB97_RS02300	COG2271	Major facilitator Superfamily
DWB97_RS02315	COG3764	Sortase (surface protein transpeptidase)
DWB97_RS02320	COG1929	Belongs to the glycerate kinase type-1 family
DWB97_RS02340	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DWB97_RS02345	COG1882	Formate acetyltransferase
DWB97_RS02350	COG0702	epimerase
DWB97_RS02360	COG3775	system Galactitol-specific IIC component
DWB97_RS02380	COG1760	l-serine dehydratase
DWB97_RS02385	COG1760	l-serine dehydratase
DWB97_RS02410	COG3201	nicotinamide mononucleotide transporter
DWB97_RS02415	COG0471	metal ion transport
DWB97_RS02430	COG0454	-acetyltransferase
DWB97_RS02440	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DWB97_RS02440	COG1648	precorrin-2 dehydrogenase activity
DWB97_RS02445	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DWB97_RS02450	COG2146	nitrite reductase [NAD(P)H] activity
DWB97_RS02455	COG1648	precorrin-2 dehydrogenase activity
DWB97_RS02455	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DWB97_RS02460	COG0737	Belongs to the 5'-nucleotidase family
DWB97_RS02465	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
DWB97_RS02470	COG1140	nitrate reductase beta subunit
DWB97_RS02475	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
DWB97_RS02480	COG2181	nitrate reductase activity
DWB97_RS02490	COG4585	Histidine kinase
DWB97_RS02495	COG2197	response regulator
DWB97_RS02500	COG2223	nitrite transmembrane transporter activity
DWB97_RS02505	COG4187	Peptidase family M20/M25/M40
DWB97_RS02515	COG1363	Peptidase, m42
DWB97_RS02520	COG0697	spore germination
DWB97_RS02540	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DWB97_RS02555	COG1846	Transcriptional regulator
DWB97_RS02560	COG1283	sodium-dependent phosphate transmembrane transporter activity
DWB97_RS02585	COG0492	ferredoxin-NADP+ reductase activity
DWB97_RS02590	COG2814	Major facilitator Superfamily
DWB97_RS02595	COG0604	alcohol dehydrogenase
DWB97_RS02610	COG1620	l-lactate permease
DWB97_RS02620	COG0579	oxidoreductase
DWB97_RS02625	COG5002	protein histidine kinase activity
DWB97_RS02625	COG3850	Histidine kinase
DWB97_RS02635	COG0577	efflux transmembrane transporter activity
DWB97_RS02640	COG1136	(ABC) transporter
DWB97_RS02645	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
DWB97_RS02660	COG4640	response to antibiotic
DWB97_RS02680	COG0657	acetylesterase activity
DWB97_RS02695	COG1304	FMN binding
DWB97_RS02700	COG0523	cobalamin synthesis protein
DWB97_RS02705	COG0786	glutamate:sodium symporter activity
DWB97_RS02710	COG2207	Transcriptional regulator
DWB97_RS02720	COG1757	Na H antiporter
DWB97_RS02725	COG2094	Belongs to the DNA glycosylase MPG family
DWB97_RS02730	COG3152	Membrane
DWB97_RS02735	COG4152	abc transporter atp-binding protein
DWB97_RS02740	COG1668	transmembrane transport
DWB97_RS02745	COG1742	UPF0060 membrane protein
DWB97_RS02750	COG1476	TRANSCRIPTIONal
DWB97_RS02760	COG2258	MOSC domain
DWB97_RS02765	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DWB97_RS02770	COG1266	CAAX protease self-immunity
DWB97_RS02780	COG0583	DNA-binding transcription factor activity
DWB97_RS02785	COG3314	Sporulation integral membrane protein YlbJ
DWB97_RS02790	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DWB97_RS02795	COG1228	amidohydrolase
DWB97_RS02800	COG0659	secondary active sulfate transmembrane transporter activity
DWB97_RS02805	COG1473	amidohydrolase
DWB97_RS02825	COG0385	Bile acid
DWB97_RS02835	COG0346	lactoylglutathione lyase activity
DWB97_RS02840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DWB97_RS02865	COG1113	amino acid transport
DWB97_RS02870	COG1263	PTS System
DWB97_RS02870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DWB97_RS02875	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DWB97_RS02900	COG0483	inositol monophosphate 1-phosphatase activity
DWB97_RS02905	COG1316	TRANSCRIPTIONal
DWB97_RS02910	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
DWB97_RS02915	COG3383	formate dehydrogenase (NAD+) activity
DWB97_RS02960	COG1757	Na H antiporter
DWB97_RS02995	COG1960	acyl-CoA dehydrogenase activity
DWB97_RS03000	COG2832	Protein of unknown function (DUF454)
DWB97_RS03005	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DWB97_RS03015	COG1268	BioY protein
DWB97_RS03030	COG0725	ABC transporter, periplasmic molybdate-binding protein
DWB97_RS03035	COG4149	molybdate abc transporter
DWB97_RS03040	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DWB97_RS03045	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DWB97_RS03050	COG0521	Mo-molybdopterin cofactor biosynthetic process
DWB97_RS03055	COG0315	cyclic pyranopterin monophosphate synthase activity
DWB97_RS03080	COG0746	molybdenum cofactor guanylyltransferase activity
DWB97_RS03085	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DWB97_RS03110	COG2348	transferase activity, transferring amino-acyl groups
DWB97_RS03115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DWB97_RS03120	COG0436	Aminotransferase
DWB97_RS03145	COG2252	PERMEase
DWB97_RS03155	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DWB97_RS03160	COG0088	Forms part of the polypeptide exit tunnel
DWB97_RS03165	COG0089	rRNA binding
DWB97_RS03170	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DWB97_RS03175	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DWB97_RS03180	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DWB97_RS03185	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DWB97_RS03195	COG0255	Belongs to the universal ribosomal protein uL29 family
DWB97_RS03205	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DWB97_RS03210	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DWB97_RS03220	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DWB97_RS03225	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DWB97_RS03240	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DWB97_RS03245	COG1841	ribosomal large subunit assembly
DWB97_RS03255	COG0201	protein transport
DWB97_RS03270	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DWB97_RS03280	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DWB97_RS03285	COG0202	RNA polymerase activity
DWB97_RS03290	COG0203	ribosomal protein L17
DWB97_RS03295	COG1122	ATPase activity
DWB97_RS03300	COG1122	ATPase activity
DWB97_RS03310	COG0101	tRNA pseudouridine synthase activity
DWB97_RS03330	COG0698	ribose 5-phosphate isomerase
DWB97_RS03355	COG2723	6-phospho-beta-galactosidase activity
DWB97_RS03360	COG0604	alcohol dehydrogenase
DWB97_RS03365	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DWB97_RS03375	COG2814	Major facilitator Superfamily
DWB97_RS03380	COG4264	IucA IucC family
DWB97_RS03385	COG2814	Major facilitator Superfamily
DWB97_RS03390	COG4264	IucA IucC family
DWB97_RS03395	COG3457	Alanine racemase
DWB97_RS03400	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DWB97_RS03405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWB97_RS03410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWB97_RS03420	COG1988	membrane-bound metal-dependent
DWB97_RS03425	COG4284	Utp--glucose-1-phosphate uridylyltransferase
DWB97_RS03430	COG1272	protein, Hemolysin III
DWB97_RS03450	COG2814	Major facilitator Superfamily
DWB97_RS03455	COG0489	protein tyrosine kinase activity
DWB97_RS03520	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DWB97_RS03525	COG0246	Mannitol dehydrogenase
DWB97_RS03535	COG3711	transcriptional antiterminator
DWB97_RS03550	COG1119	ATPase activity
DWB97_RS03565	COG2186	Transcriptional regulator
DWB97_RS03570	COG1482	cell wall glycoprotein biosynthetic process
DWB97_RS03585	COG1757	Na H antiporter
DWB97_RS03595	COG0813	purine-nucleoside phosphorylase activity
DWB97_RS03630	COG5146	pantothenate kinase activity
DWB97_RS03645	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DWB97_RS03655	COG0504	CTP synthase activity
DWB97_RS03665	COG0191	fructose-bisphosphate aldolase activity
DWB97_RS03670	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DWB97_RS03675	COG1733	regulation of RNA biosynthetic process
DWB97_RS03685	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DWB97_RS03690	COG0254	rRNA binding
DWB97_RS03700	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DWB97_RS03705	COG2890	protein-(glutamine-N5) methyltransferase activity
DWB97_RS03710	COG0009	L-threonylcarbamoyladenylate synthase
DWB97_RS03720	COG4475	Protein of unknown function (DUF436)
DWB97_RS03725	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DWB97_RS03730	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DWB97_RS03735	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DWB97_RS03745	COG0356	it plays a direct role in the translocation of protons across the membrane
DWB97_RS03750	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DWB97_RS03755	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DWB97_RS03760	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DWB97_RS03765	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DWB97_RS03770	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DWB97_RS03790	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DWB97_RS03800	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DWB97_RS03815	COG0741	lytic transglycosylase activity
DWB97_RS03820	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DWB97_RS03830	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DWB97_RS03835	COG0352	thiamine-phosphate diphosphorylase activity
DWB97_RS03840	COG0706	membrane insertase activity
DWB97_RS03845	COG1418	mRNA catabolic process
DWB97_RS03855	COG1937	Protein conserved in bacteria
DWB97_RS03865	COG2608	mercury ion transmembrane transporter activity
DWB97_RS03870	COG2217	Heavy metal translocating P-type atpase
DWB97_RS03875	COG0772	Belongs to the SEDS family
DWB97_RS03880	COG1181	Belongs to the D-alanine--D-alanine ligase family
DWB97_RS03885	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DWB97_RS03890	COG0513	Belongs to the DEAD box helicase family
DWB97_RS03910	COG0736	holo-[acyl-carrier-protein] synthase activity
DWB97_RS03925	COG2337	Toxic component of a toxin-antitoxin (TA) module
DWB97_RS03930	COG2208	phosphoserine phosphatase activity
DWB97_RS03945	COG1191	sigma factor activity
DWB97_RS03950	COG2183	response to ionizing radiation
DWB97_RS03985	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DWB97_RS03995	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DWB97_RS04000	COG0473	3-isopropylmalate dehydrogenase activity
DWB97_RS04005	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DWB97_RS04020	COG0028	Belongs to the TPP enzyme family
DWB97_RS04025	COG0129	dihydroxy-acid dehydratase activity
DWB97_RS04030	COG0802	atpase or kinase
DWB97_RS04035	COG1214	PFAM Peptidase M22, glycoprotease
DWB97_RS04040	COG0456	acetyltransferase
DWB97_RS04045	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DWB97_RS04050	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DWB97_RS04055	COG0488	(ABC) transporter
DWB97_RS04065	COG2391	methyltransferase activity
DWB97_RS04070	COG0425	Belongs to the sulfur carrier protein TusA family
DWB97_RS04075	COG1621	beta-fructofuranosidase activity
DWB97_RS04095	COG4512	PFAM Accessory gene regulator B
DWB97_RS04115	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DWB97_RS04155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DWB97_RS04160	COG1131	(ABC) transporter
DWB97_RS04170	COG1802	Transcriptional regulator
DWB97_RS04175	COG1070	Carbohydrate kinase
DWB97_RS04180	COG2610	gluconate transmembrane transporter activity
DWB97_RS04185	COG4876	unkown
DWB97_RS04220	COG2706	6-phosphogluconolactonase activity
DWB97_RS04225	COG1012	belongs to the aldehyde dehydrogenase family
DWB97_RS04235	COG1227	inorganic diphosphatase activity
DWB97_RS04240	COG1335	isochorismatase
DWB97_RS04250	COG0077	Prephenate dehydratase
DWB97_RS04260	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DWB97_RS04265	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DWB97_RS04270	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
DWB97_RS04285	COG4496	protein, YerC YecD
DWB97_RS04295	COG0210	DNA helicase
DWB97_RS04300	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DWB97_RS04305	COG4851	CamS sex pheromone cAM373 precursor
DWB97_RS04310	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DWB97_RS04315	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DWB97_RS04325	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DWB97_RS04330	COG1597	lipid kinase activity
DWB97_RS04335	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DWB97_RS04350	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DWB97_RS04360	COG1528	Iron-storage protein
DWB97_RS04375	COG4129	membrane
DWB97_RS04380	COG0024	Methionine aminopeptidase
DWB97_RS04405	COG0288	reversible hydration of carbon dioxide
DWB97_RS04410	COG1295	ribonuclease BN
DWB97_RS04420	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DWB97_RS04425	COG4840	Belongs to the UPF0435 family
DWB97_RS04430	COG2309	aminopeptidase activity
DWB97_RS04435	COG1607	acyl-coa hydrolase
DWB97_RS04440	COG0535	radical SAM domain protein
DWB97_RS04445	COG0693	protein deglycase activity
DWB97_RS04450	COG0028	Belongs to the TPP enzyme family
DWB97_RS04455	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DWB97_RS04460	COG2137	regulation of response to DNA damage stimulus
DWB97_RS04470	COG1134	teichoic acid transport
DWB97_RS04470	COG1388	LysM domain
DWB97_RS04485	COG1988	membrane-bound metal-dependent
DWB97_RS04490	COG1194	a g-specific adenine glycosylase
DWB97_RS04495	COG3557	Belongs to the UPF0374 family
DWB97_RS04505	COG0069	glutamate synthase activity
DWB97_RS04510	COG4129	membrane
DWB97_RS04515	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DWB97_RS04520	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DWB97_RS04525	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DWB97_RS04530	COG0735	belongs to the Fur family
DWB97_RS04695	COG0765	amino acid transport
DWB97_RS04700	COG1126	abc transporter atp-binding protein
DWB97_RS04705	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DWB97_RS04715	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DWB97_RS04720	COG0363	glucosamine-6-phosphate deaminase activity
DWB97_RS04730	COG0114	fumarate hydratase activity
DWB97_RS04740	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DWB97_RS04745	COG0564	pseudouridine synthase activity
DWB97_RS04750	COG4585	Histidine kinase
DWB97_RS04750	COG2203	Gaf domain
DWB97_RS04755	COG2197	response regulator
DWB97_RS04765	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DWB97_RS04775	COG1301	dicarboxylic acid transport
DWB97_RS04815	COG3679	Belongs to the UPF0342 family
DWB97_RS04820	COG0420	3'-5' exonuclease activity
DWB97_RS04825	COG4717	serine-type aminopeptidase activity
DWB97_RS04830	COG3481	metal-dependent phosphohydrolase, HD sub domain
DWB97_RS04835	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DWB97_RS04845	COG1846	Transcriptional regulator
DWB97_RS04855	COG0537	adenosine 5'-monophosphoramidase activity
DWB97_RS04860	COG1131	(ABC) transporter
DWB97_RS04875	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DWB97_RS04880	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DWB97_RS04885	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DWB97_RS04975	COG1028	Short-chain dehydrogenase reductase Sdr
DWB97_RS04990	COG1302	Protein conserved in bacteria
DWB97_RS04995	COG0318	PFAM AMP-dependent synthetase and ligase
DWB97_RS05005	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DWB97_RS05015	COG1506	peptidase
DWB97_RS05020	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
DWB97_RS05025	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DWB97_RS05035	COG0656	L-ascorbic acid biosynthetic process
DWB97_RS05040	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DWB97_RS05045	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DWB97_RS05055	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DWB97_RS05070	COG1595	DNA-templated transcription, initiation
DWB97_RS05080	COG4193	domain, Protein
DWB97_RS05080	COG3266	domain, Protein
DWB97_RS05080	COG5632	N-Acetylmuramoyl-L-alanine amidase
DWB97_RS05090	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DWB97_RS05090	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DWB97_RS05100	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DWB97_RS05100	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DWB97_RS05105	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DWB97_RS05110	COG0506	proline dehydrogenase activity
DWB97_RS05120	COG2267	carboxylic ester hydrolase activity
DWB97_RS05125	COG0039	L-malate dehydrogenase activity
DWB97_RS05135	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DWB97_RS05140	COG1242	4 iron, 4 sulfur cluster binding
DWB97_RS05145	COG2814	Major facilitator Superfamily
DWB97_RS05150	COG0495	leucyl-tRNA aminoacylation
DWB97_RS05155	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DWB97_RS05160	COG2081	HI0933 family
DWB97_RS05165	COG2244	polysaccharide biosynthetic process
DWB97_RS05170	COG1187	pseudouridine synthase activity
DWB97_RS05185	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DWB97_RS05190	COG0510	thiamine kinase activity
DWB97_RS05195	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DWB97_RS05200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DWB97_RS05210	COG1363	Peptidase, m42
DWB97_RS05215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DWB97_RS05225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DWB97_RS05230	COG1674	ftsk spoiiie
DWB97_RS05235	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DWB97_RS05240	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
DWB97_RS05250	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DWB97_RS05250	COG1605	Chorismate mutase
DWB97_RS05255	COG1609	Transcriptional regulator
DWB97_RS05260	COG0123	including yeast histone deacetylase and acetoin utilization protein
DWB97_RS05265	COG0454	-acetyltransferase
DWB97_RS05270	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DWB97_RS05275	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DWB97_RS05280	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DWB97_RS05290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DWB97_RS05295	COG0204	Acyl-transferase
DWB97_RS05305	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DWB97_RS05310	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DWB97_RS05315	COG1764	response to oxidative stress
DWB97_RS05320	COG0584	glycerophosphoryl diester phosphodiesterase
DWB97_RS05330	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DWB97_RS05335	COG1956	GAF domain-containing protein
DWB97_RS05340	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
DWB97_RS05345	COG1104	cysteine desulfurase activity
DWB97_RS05350	COG0301	tRNA thio-modification
DWB97_RS05355	COG0730	response to heat
DWB97_RS05360	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DWB97_RS05365	COG0827	DNA restriction-modification system
DWB97_RS05370	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DWB97_RS05375	COG0589	response to stress
DWB97_RS05390	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DWB97_RS05400	COG4109	DRTGG domain
DWB97_RS05405	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DWB97_RS05410	COG0587	DNA-directed DNA polymerase activity
DWB97_RS05415	COG0281	malic enzyme
DWB97_RS05420	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DWB97_RS05425	COG0825	malonyl-CoA metabolic process
DWB97_RS05430	COG0205	6-phosphofructokinase activity
DWB97_RS05435	COG0469	pyruvate kinase activity
DWB97_RS05440	COG0372	Belongs to the citrate synthase family
DWB97_RS05450	COG0745	RESPONSE REGULATOR receiver
DWB97_RS05455	COG5002	protein histidine kinase activity
DWB97_RS05460	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DWB97_RS05460	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DWB97_RS05465	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DWB97_RS05470	COG0237	dephospho-CoA kinase activity
DWB97_RS05475	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DWB97_RS05480	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DWB97_RS05485	COG3611	Membrane attachment protein
DWB97_RS05490	COG1484	DNA-dependent DNA replication
DWB97_RS05500	COG0833	amino acid
DWB97_RS05505	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DWB97_RS05510	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DWB97_RS05530	COG0544	peptidyl-prolyl cis-trans isomerase activity
DWB97_RS05540	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DWB97_RS05545	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DWB97_RS05550	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DWB97_RS05555	COG0181	hydroxymethylbilane synthase activity
DWB97_RS05575	COG3180	Ammonia monooxygenase
DWB97_RS05580	COG2818	Glycosylase
DWB97_RS05585	COG0525	valine-tRNA ligase activity
DWB97_RS05590	COG0285	dihydrofolate synthase activity
DWB97_RS05600	COG2003	Belongs to the UPF0758 family
DWB97_RS05620	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DWB97_RS05625	COG2868	ribosomal protein
DWB97_RS05630	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DWB97_RS05650	COG2255	four-way junction helicase activity
DWB97_RS05665	COG1862	Preprotein translocase
DWB97_RS05670	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DWB97_RS05670	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DWB97_RS05675	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DWB97_RS05675	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DWB97_RS05680	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DWB97_RS05690	COG1490	D-aminoacyl-tRNA deacylase activity
DWB97_RS05700	COG0124	histidyl-tRNA synthetase
DWB97_RS05705	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DWB97_RS05715	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DWB97_RS05720	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DWB97_RS05725	COG1959	2 iron, 2 sulfur cluster binding
DWB97_RS05735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWB97_RS05740	COG1104	cysteine desulfurase activity
DWB97_RS05745	COG0482	sulfurtransferase activity
DWB97_RS05755	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DWB97_RS05765	COG4472	Bacterial protein of unknown function (DUF965)
DWB97_RS05770	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DWB97_RS05775	COG3906	Belongs to the UPF0473 family
DWB97_RS05780	COG4122	O-methyltransferase activity
DWB97_RS05785	COG0826	peptidase U32
DWB97_RS05790	COG0826	peptidase U32
DWB97_RS05795	COG0572	uridine kinase
DWB97_RS05800	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DWB97_RS05805	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DWB97_RS05810	COG1984	allophanate hydrolase subunit 2
DWB97_RS05815	COG0511	ligase activity, forming carbon-carbon bonds
DWB97_RS05820	COG0439	Biotin carboxylase
DWB97_RS05825	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DWB97_RS05830	COG1914	H( )-stimulated, divalent metal cation uptake system
DWB97_RS05835	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DWB97_RS05840	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
DWB97_RS05845	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DWB97_RS05850	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DWB97_RS05855	COG1534	Rna-binding protein
DWB97_RS05865	COG1713	HD superfamily hydrolase involved in NAD metabolism
DWB97_RS05870	COG0799	negative regulation of ribosome biogenesis
DWB97_RS05875	COG2226	methyltransferase
DWB97_RS05880	COG1596	polysaccharide export
DWB97_RS05880	COG1555	photosystem II stabilization
DWB97_RS05885	COG2131	deaminase
DWB97_RS05890	COG2333	competence protein COMEC
DWB97_RS05890	COG0658	competence protein
DWB97_RS05895	COG1466	dna polymerase III delta subunit
DWB97_RS05900	COG0268	Binds directly to 16S ribosomal RNA
DWB97_RS05910	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DWB97_RS05915	COG1420	regulation of RNA biosynthetic process
DWB97_RS05925	COG0443	Heat shock 70 kDa protein
DWB97_RS05930	COG0484	heat shock protein binding
DWB97_RS05935	COG2264	protein methyltransferase activity
DWB97_RS05940	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DWB97_RS05945	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DWB97_RS05955	COG1030	water channel activity
DWB97_RS05960	COG4864	UPF0365 protein
DWB97_RS05970	COG1702	phosphate starvation-inducible protein PhoH
DWB97_RS05975	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DWB97_RS05985	COG0295	cytidine deaminase activity
DWB97_RS05990	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DWB97_RS05995	COG1381	Involved in DNA repair and RecF pathway recombination
DWB97_RS06000	COG0423	glycine-tRNA ligase activity
DWB97_RS06005	COG0517	IMP dehydrogenase activity
DWB97_RS06010	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DWB97_RS06015	COG0358	DNA primase activity
DWB97_RS06020	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DWB97_RS06025	COG2384	SAM-dependent methyltransferase
DWB97_RS06030	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DWB97_RS06035	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DWB97_RS06040	COG0513	Belongs to the DEAD box helicase family
DWB97_RS06045	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DWB97_RS06050	COG1121	(ABC) transporter
DWB97_RS06055	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DWB97_RS06065	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DWB97_RS06075	COG0768	penicillin binding
DWB97_RS06080	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DWB97_RS06085	COG0573	inorganic phosphate transmembrane transporter activity
DWB97_RS06090	COG0581	inorganic phosphate transmembrane transporter activity
DWB97_RS06095	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DWB97_RS06100	COG0704	Plays a role in the regulation of phosphate uptake
DWB97_RS06105	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DWB97_RS06110	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DWB97_RS06115	COG0457	Tetratricopeptide repeat
DWB97_RS06115	COG0705	Rhomboid family
DWB97_RS06120	COG4483	Protein conserved in bacteria
DWB97_RS06125	COG1940	carbohydrate kinase activity
DWB97_RS06130	COG0011	TIGRFAM Protein of
DWB97_RS06135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DWB97_RS06140	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DWB97_RS06145	COG1459	type II secretion system
DWB97_RS06150	COG4537	Required for transformation and DNA binding
DWB97_RS06170	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DWB97_RS06175	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DWB97_RS06180	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DWB97_RS06185	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DWB97_RS06190	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DWB97_RS06195	COG0095	Lipoate-protein ligase
DWB97_RS06210	COG0006	proline dipeptidase activity
DWB97_RS06215	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DWB97_RS06220	COG0511	ligase activity, forming carbon-carbon bonds
DWB97_RS06225	COG0439	Biotin carboxylase
DWB97_RS06230	COG1302	Protein conserved in bacteria
DWB97_RS06235	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DWB97_RS06245	COG1722	exodeoxyribonuclease VII activity
DWB97_RS06255	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DWB97_RS06260	COG1438	arginine binding
DWB97_RS06265	COG0497	DNA recombination
DWB97_RS06270	COG0280	phosphate acetyltransferase
DWB97_RS06280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DWB97_RS06285	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DWB97_RS06290	COG0022	dehydrogenase e1 component
DWB97_RS06295	COG0508	dehydrogenase complex catalyzes the overall conversion of
DWB97_RS06305	COG4129	membrane
DWB97_RS06310	COG2195	Cleaves the N-terminal amino acid of tripeptides
DWB97_RS06325	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DWB97_RS06330	COG1234	tRNA 3'-trailer cleavage
DWB97_RS06335	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DWB97_RS06340	COG0667	Aldo Keto reductase
DWB97_RS06345	COG0494	nUDIX hydrolase
DWB97_RS06350	COG0735	belongs to the Fur family
DWB97_RS06355	COG4974	Belongs to the 'phage' integrase family
DWB97_RS06365	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DWB97_RS06370	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DWB97_RS06375	COG1187	pseudouridine synthase activity
DWB97_RS06380	COG0745	RESPONSE REGULATOR receiver
DWB97_RS06385	COG5002	protein histidine kinase activity
DWB97_RS06395	COG1141	Ferredoxin
DWB97_RS06405	COG0514	ATP-dependent DNA helicase (RecQ)
DWB97_RS06415	COG0492	ferredoxin-NADP+ reductase activity
DWB97_RS06425	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DWB97_RS06430	COG0539	negative regulation of cytoplasmic translation
DWB97_RS06455	COG2226	methyltransferase
DWB97_RS06460	COG0142	geranyltranstransferase activity
DWB97_RS06465	COG0105	UTP biosynthetic process
DWB97_RS06470	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DWB97_RS06475	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DWB97_RS06485	COG0457	Tetratricopeptide repeat
DWB97_RS06490	COG5582	Belongs to the UPF0302 family
DWB97_RS06495	COG4347	Protein of unknown function (DUF1405)
DWB97_RS06500	COG2738	Putative neutral zinc metallopeptidase
DWB97_RS06505	COG1694	Mazg nucleotide pyrophosphohydrolase
DWB97_RS06510	COG0438	transferase activity, transferring glycosyl groups
DWB97_RS06515	COG0617	tRNA 3'-terminal CCA addition
DWB97_RS06530	COG0017	Asparaginyl-tRNA synthetase
DWB97_RS06535	COG3935	DnaD domain protein
DWB97_RS06540	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DWB97_RS06550	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DWB97_RS06550	COG4499	WXG100 protein secretion system (Wss), protein YukC
DWB97_RS06555	COG3331	DNA recombination
DWB97_RS06565	COG4474	Belongs to the UPF0398 family
DWB97_RS06570	COG3599	regulation of cell shape
DWB97_RS06580	COG0116	Belongs to the methyltransferase superfamily
DWB97_RS06585	COG2962	Rard protein
DWB97_RS06590	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DWB97_RS06595	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DWB97_RS06605	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DWB97_RS06615	COG1413	lyase activity
DWB97_RS06625	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DWB97_RS06645	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DWB97_RS06655	COG4479	Belongs to the UPF0346 family
DWB97_RS06675	COG0671	phosphoesterase, PA-phosphatase related
DWB97_RS06685	COG5002	protein histidine kinase activity
DWB97_RS06690	COG0567	Dehydrogenase, E1 component
DWB97_RS06710	COG0714	Associated with various cellular activities
DWB97_RS06715	COG4548	von Willebrand factor, type A
DWB97_RS06720	COG1114	Component of the transport system for branched-chain amino acids
DWB97_RS06725	COG3853	Toxic anion resistance protein (TelA)
DWB97_RS06745	COG1278	Cold shock
DWB97_RS06760	COG1473	amidohydrolase
DWB97_RS06765	COG2171	N-acyltransferase activity
DWB97_RS06770	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DWB97_RS06775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DWB97_RS06780	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DWB97_RS06785	COG0488	(ABC) transporter
DWB97_RS06790	COG2996	Protein conserved in bacteria
DWB97_RS06800	COG1164	Oligoendopeptidase f
DWB97_RS06815	COG2348	transferase activity, transferring amino-acyl groups
DWB97_RS06820	COG0287	Prephenate dehydrogenase
DWB97_RS06825	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DWB97_RS06855	COG0628	permease
DWB97_RS06865	COG3711	transcriptional antiterminator
DWB97_RS06870	COG1115	amino acid carrier protein
DWB97_RS06875	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DWB97_RS06880	COG0187	DNA topoisomerase II activity
DWB97_RS06885	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DWB97_RS06890	COG4841	protein insertion into membrane
DWB97_RS06895	COG0824	Thioesterase
DWB97_RS06905	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DWB97_RS06910	COG1970	mechanosensitive ion channel activity
DWB97_RS06915	COG0419	ATPase involved in DNA repair
DWB97_RS06920	COG0420	3'-5' exonuclease activity
DWB97_RS06925	COG4846	Membrane protein involved in cytochrome C biogenesis
DWB97_RS06930	COG3763	UPF0154 protein
DWB97_RS06940	COG4224	UPF0291 protein
DWB97_RS06950	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DWB97_RS06960	COG0516	GMP reductase activity
DWB97_RS06965	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DWB97_RS06975	COG0753	catalase activity
DWB97_RS06980	COG0833	amino acid
DWB97_RS06990	COG0561	phosphatase activity
DWB97_RS06995	COG0083	homoserine kinase activity
DWB97_RS07000	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DWB97_RS07005	COG0460	homoserine dehydrogenase
DWB97_RS07010	COG0527	aspartate kinase activity
DWB97_RS07035	COG2197	response regulator
DWB97_RS07040	COG4585	Histidine kinase
DWB97_RS07050	COG4172	Belongs to the ABC transporter superfamily
DWB97_RS07075	COG0789	Transcriptional regulator
DWB97_RS07080	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
DWB97_RS07085	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DWB97_RS07090	COG0386	Belongs to the glutathione peroxidase family
DWB97_RS07095	COG1923	regulation of RNA biosynthetic process
DWB97_RS07105	COG2267	carboxylic ester hydrolase activity
DWB97_RS07110	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DWB97_RS07120	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DWB97_RS07125	COG1619	proteins homologs of microcin C7 resistance protein MccF
DWB97_RS07135	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DWB97_RS07155	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DWB97_RS07165	COG1013	pyruvate-flavodoxin oxidoreductase activity
DWB97_RS07170	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DWB97_RS07170	COG0674	pyruvate-flavodoxin oxidoreductase activity
DWB97_RS07175	COG1692	metallophosphoesterase
DWB97_RS07200	COG1418	mRNA catabolic process
DWB97_RS07205	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DWB97_RS07210	COG1058	Belongs to the CinA family
DWB97_RS07210	COG1546	Belongs to the CinA family
DWB97_RS07230	COG0300	oxidoreductase activity
DWB97_RS07235	COG0612	Peptidase, M16
DWB97_RS07240	COG0612	Peptidase, M16
DWB97_RS07245	COG2188	Transcriptional regulator
DWB97_RS07255	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DWB97_RS07270	COG1185	polyribonucleotide nucleotidyltransferase activity
DWB97_RS07280	COG0196	riboflavin kinase activity
DWB97_RS07285	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DWB97_RS07290	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DWB97_RS07300	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DWB97_RS07305	COG1358	cellular component organization or biogenesis
DWB97_RS07310	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DWB97_RS07315	COG0195	Participates in both transcription termination and antitermination
DWB97_RS07320	COG0779	Required for maturation of 30S ribosomal subunits
DWB97_RS07330	COG0442	prolyl-tRNA aminoacylation
DWB97_RS07340	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DWB97_RS07345	COG4589	Belongs to the CDS family
DWB97_RS07350	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DWB97_RS07355	COG0233	cytoplasmic translational termination
DWB97_RS07360	COG0528	UMP kinase activity
DWB97_RS07365	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DWB97_RS07370	COG0052	Belongs to the universal ribosomal protein uS2 family
DWB97_RS07375	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
DWB97_RS07380	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DWB97_RS07390	COG4974	Belongs to the 'phage' integrase family
DWB97_RS07395	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DWB97_RS07400	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DWB97_RS07405	COG0758	DNA mediated transformation
DWB97_RS07415	COG0045	succinate-CoA ligase (ADP-forming) activity
DWB97_RS07425	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DWB97_RS07440	COG4485	Bacterial membrane protein, YfhO
DWB97_RS07445	COG4485	Bacterial membrane protein, YfhO
DWB97_RS07450	COG0671	phosphoesterase, PA-phosphatase related
DWB97_RS07455	COG0335	large ribosomal subunit rRNA binding
DWB97_RS07460	COG0336	Belongs to the RNA methyltransferase TrmD family
DWB97_RS07470	COG0228	four-way junction DNA binding
DWB97_RS07475	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DWB97_RS07480	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
DWB97_RS07485	COG0552	protein localization to endoplasmic reticulum
DWB97_RS07490	COG1196	nuclear chromosome segregation
DWB97_RS07495	COG0571	ribonuclease III activity
DWB97_RS07500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DWB97_RS07505	COG1028	Short-chain dehydrogenase reductase Sdr
DWB97_RS07520	COG1349	DNA-binding transcription factor activity
DWB97_RS07530	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DWB97_RS07535	COG1760	l-serine dehydratase
DWB97_RS07540	COG1760	l-serine dehydratase
DWB97_RS07550	COG1302	Protein conserved in bacteria
DWB97_RS07560	COG1564	THIamine pyrophosphokinase
DWB97_RS07565	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DWB97_RS07570	COG1162	GTPase activity
DWB97_RS07575	COG2124	cytochrome p450
DWB97_RS07590	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DWB97_RS07595	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DWB97_RS07595	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DWB97_RS07600	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DWB97_RS07605	COG0242	peptide deformylase activity
DWB97_RS07610	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DWB97_RS07615	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DWB97_RS07620	COG1758	RNA polymerase activity
DWB97_RS07630	COG1293	RNA-binding protein homologous to eukaryotic snRNP
DWB97_RS07640	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DWB97_RS07650	COG0167	dihydroorotate dehydrogenase activity
DWB97_RS07655	COG0543	2 iron, 2 sulfur cluster binding
DWB97_RS07660	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DWB97_RS07665	COG0505	Belongs to the CarA family
DWB97_RS07675	COG0540	Belongs to the ATCase OTCase family
DWB97_RS07685	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DWB97_RS07690	COG0564	pseudouridine synthase activity
DWB97_RS07695	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DWB97_RS07705	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DWB97_RS07710	COG3599	regulation of cell shape
DWB97_RS07720	COG0762	integral membrane protein
DWB97_RS07725	COG1799	cell septum assembly
DWB97_RS07730	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DWB97_RS07735	COG1496	oxidoreductase activity
DWB97_RS07740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DWB97_RS07745	COG0849	cell division
DWB97_RS07755	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DWB97_RS07765	COG0768	penicillin binding
DWB97_RS07770	COG4839	cell division protein FtsL
DWB97_RS07775	COG0275	rRNA processing
DWB97_RS07780	COG2001	Belongs to the MraZ family
DWB97_RS07785	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
DWB97_RS07790	COG0454	-acetyltransferase
DWB97_RS07810	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DWB97_RS07865	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DWB97_RS07870	COG1053	succinate dehydrogenase
DWB97_RS07875	COG2009	succinate dehydrogenase
DWB97_RS07880	COG0322	excinuclease ABC activity
DWB97_RS07885	COG3118	belongs to the thioredoxin family
DWB97_RS07890	COG1193	negative regulation of DNA recombination
DWB97_RS07895	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DWB97_RS07895	COG1796	DNA polymerase
DWB97_RS07905	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
DWB97_RS07910	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DWB97_RS07915	COG0072	phenylalanine-tRNA ligase activity
DWB97_RS07920	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DWB97_RS07925	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DWB97_RS07930	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DWB97_RS07940	COG1323	Belongs to the UPF0348 family
DWB97_RS07945	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DWB97_RS07950	COG0742	ribosomal rna small subunit methyltransferase
DWB97_RS07965	COG0584	glycerophosphoryl diester phosphodiesterase
DWB97_RS07970	COG3679	Belongs to the UPF0342 family
DWB97_RS07985	COG0109	protoheme IX farnesyltransferase activity
DWB97_RS07990	COG1612	heme a metabolic process
DWB97_RS08000	COG0772	Belongs to the SEDS family
DWB97_RS08005	COG4838	Belongs to the UPF0358 family
DWB97_RS08010	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DWB97_RS08015	COG4896	Protein conserved in bacteria
DWB97_RS08020	COG1902	pentaerythritol trinitrate reductase activity
DWB97_RS08025	COG1217	gtp-binding protein TYPA
DWB97_RS08035	COG0483	inositol monophosphate 1-phosphatase activity
DWB97_RS08040	COG4493	Belongs to the UPF0637 family
DWB97_RS08055	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DWB97_RS08060	COG1177	transmembrane transport
DWB97_RS08070	COG3842	ATPase activity
DWB97_RS08080	COG4476	Belongs to the UPF0223 family
DWB97_RS08110	COG0242	peptide deformylase activity
DWB97_RS08120	COG5503	Protein of unknown function (DUF1447)
DWB97_RS08125	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DWB97_RS08130	COG0569	domain protein
DWB97_RS08135	COG1294	oxidase, subunit
DWB97_RS08140	COG1271	oxidase subunit
DWB97_RS08150	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DWB97_RS08165	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DWB97_RS08175	COG4721	ABC-type cobalt transport system, permease component
DWB97_RS08180	COG1122	ATPase activity
DWB97_RS08190	COG0151	Belongs to the GarS family
DWB97_RS08195	COG0138	bifunctional purine biosynthesis protein purh
DWB97_RS08205	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DWB97_RS08210	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DWB97_RS08215	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DWB97_RS08225	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DWB97_RS08230	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DWB97_RS08240	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DWB97_RS08245	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DWB97_RS08250	COG1017	nitric oxide dioxygenase activity
DWB97_RS08250	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DWB97_RS08270	COG1845	cytochrome c oxidase, subunit III
DWB97_RS08275	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DWB97_RS08285	COG1134	teichoic acid transport
DWB97_RS08305	COG0438	transferase activity, transferring glycosyl groups
DWB97_RS08310	COG0463	Glycosyl transferase, family 2
DWB97_RS08310	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DWB97_RS08330	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DWB97_RS08335	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DWB97_RS08340	COG1316	TRANSCRIPTIONal
DWB97_RS08365	COG3594	Acyltransferase
DWB97_RS08370	COG0436	Aminotransferase
DWB97_RS08375	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DWB97_RS08380	COG0596	Alpha beta hydrolase
DWB97_RS08385	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DWB97_RS08390	COG1169	isochorismate synthase
DWB97_RS08395	COG1575	Belongs to the MenA family. Type 1 subfamily
DWB97_RS08405	COG4619	ABC transporter
DWB97_RS08430	COG5632	N-Acetylmuramoyl-L-alanine amidase
DWB97_RS08430	COG1388	LysM domain
DWB97_RS08685	COG0582	viral genome integration into host DNA
DWB97_RS08725	COG4873	Protein conserved in bacteria
DWB97_RS08740	COG0737	Belongs to the 5'-nucleotidase family
DWB97_RS08745	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DWB97_RS08750	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DWB97_RS08755	COG0861	Integral membrane protein TerC family
DWB97_RS08770	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DWB97_RS08775	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DWB97_RS08780	COG2814	Major facilitator Superfamily
DWB97_RS08785	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DWB97_RS08790	COG2382	esterase
DWB97_RS08795	COG1115	amino acid carrier protein
DWB97_RS08800	COG0628	permease
DWB97_RS08810	COG0475	glutathione-regulated potassium exporter activity
DWB97_RS08810	COG0569	domain protein
DWB97_RS08815	COG2239	Acts as a magnesium transporter
DWB97_RS08820	COG0564	pseudouridine synthase activity
DWB97_RS08825	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DWB97_RS08830	COG2357	RelA SpoT domain protein
DWB97_RS08845	COG2346	COG2346, Truncated hemoglobins
DWB97_RS08850	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DWB97_RS08855	COG1164	Oligoendopeptidase f
DWB97_RS08870	COG1393	Belongs to the ArsC family
DWB97_RS08880	COG4166	transmembrane transport
DWB97_RS08885	COG4608	Belongs to the ABC transporter superfamily
DWB97_RS08890	COG0444	Belongs to the ABC transporter superfamily
DWB97_RS08895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DWB97_RS08900	COG0601	transmembrane transport
DWB97_RS08925	COG0542	response to heat
DWB97_RS08930	COG2151	metal-sulfur cluster biosynthetic enzyme
DWB97_RS08935	COG0561	phosphatase activity
DWB97_RS08940	COG0446	pyridine nucleotide-disulphide oxidoreductase
DWB97_RS08950	COG0179	Fumarylacetoacetate (FAA) hydrolase
DWB97_RS08960	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
DWB97_RS08970	COG0681	Belongs to the peptidase S26 family
DWB97_RS08975	COG0166	Belongs to the GPI family
DWB97_RS08980	COG0137	argininosuccinate synthase activity
DWB97_RS08985	COG0165	Argininosuccinate lyase
DWB97_RS08990	COG0584	glycerophosphoryl diester phosphodiesterase
DWB97_RS09005	COG1012	belongs to the aldehyde dehydrogenase family
DWB97_RS09010	COG1098	S1 RNA binding domain
DWB97_RS09030	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DWB97_RS09040	COG2111	Na H antiporter
DWB97_RS09040	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DWB97_RS09045	COG2111	Na H antiporter
DWB97_RS09050	COG1006	Multisubunit Na H antiporter MnhC subunit
DWB97_RS09055	COG0651	ATP synthesis coupled electron transport
DWB97_RS09060	COG1863	multisubunit Na H antiporter MnhE subunit
DWB97_RS09065	COG2212	antiporter activity
DWB97_RS09070	COG1320	monovalent cation:proton antiporter activity
DWB97_RS09075	COG2050	protein possibly involved in aromatic compounds catabolism
DWB97_RS09080	COG2056	Na+-H+ antiporter family
DWB97_RS09085	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DWB97_RS09090	COG1252	NADH dehydrogenase
DWB97_RS09095	COG0316	Belongs to the HesB IscA family
DWB97_RS09100	COG4844	belongs to the
DWB97_RS09105	COG1252	NADH dehydrogenase
DWB97_RS09110	COG4837	Protein of unknown function (DUF1462)
DWB97_RS09115	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DWB97_RS09120	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
DWB97_RS09130	COG1696	Membrane protein involved in D-alanine export
DWB97_RS09145	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DWB97_RS09155	COG2445	Protein of unknown function DUF86
DWB97_RS09165	COG0706	membrane insertase activity
DWB97_RS09170	COG4470	Protein conserved in bacteria
DWB97_RS09180	COG0737	Belongs to the 5'-nucleotidase family
DWB97_RS09185	COG0730	response to heat
DWB97_RS09190	COG1801	Protein of unknown function DUF72
DWB97_RS09205	COG1253	flavin adenine dinucleotide binding
DWB97_RS09210	COG0719	Fe-S assembly protein
DWB97_RS09215	COG0822	iron-sulfur transferase activity
DWB97_RS09225	COG0719	Fe-S assembly protein
DWB97_RS09230	COG0396	ATPase activity
DWB97_RS09240	COG1464	Belongs to the NlpA lipoprotein family
DWB97_RS09245	COG2011	ABC-type metal ion transport system permease component
DWB97_RS09250	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DWB97_RS09255	COG0492	ferredoxin-NADP+ reductase activity
DWB97_RS09255	COG3118	belongs to the thioredoxin family
DWB97_RS09270	COG1393	Belongs to the ArsC family
DWB97_RS09275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DWB97_RS09300	COG0710	3-dehydroquinate dehydratase activity
DWB97_RS09305	COG1764	response to oxidative stress
DWB97_RS09320	COG0477	Major facilitator Superfamily
DWB97_RS09325	COG2217	Heavy metal translocating P-type atpase
DWB97_RS09340	COG3237	CsbD-like
DWB97_RS09360	COG1250	3-hydroxyacyl-CoA dehydrogenase
DWB97_RS09365	COG1307	EDD domain protein, DegV family
DWB97_RS09370	COG5484	DNA packaging
DWB97_RS09370	COG3728	DNA packaging
DWB97_RS09445	COG0582	viral genome integration into host DNA
DWB97_RS09460	COG0557	exoribonuclease II activity
DWB97_RS09465	COG1647	Serine aminopeptidase, S33
DWB97_RS09470	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DWB97_RS09480	COG0148	phosphopyruvate hydratase activity
DWB97_RS09485	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DWB97_RS09490	COG0149	triose-phosphate isomerase activity
DWB97_RS09495	COG0126	phosphoglycerate kinase activity
DWB97_RS09520	COG1090	epimerase
DWB97_RS09545	COG1278	Cold shock
DWB97_RS09560	COG0740	serine-type endopeptidase activity
DWB97_RS09565	COG1481	regulation of sporulation
DWB97_RS09570	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DWB97_RS09575	COG1660	Displays ATPase and GTPase activities
DWB97_RS09580	COG0492	ferredoxin-NADP+ reductase activity
DWB97_RS09590	COG0110	maltose O-acetyltransferase activity
DWB97_RS09595	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DWB97_RS09600	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DWB97_RS09640	COG0653	protein targeting
DWB97_RS09645	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DWB97_RS09655	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
DWB97_RS09665	COG1739	Uncharacterized protein family UPF0029
DWB97_RS09670	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DWB97_RS09675	COG2199	diguanylate cyclase activity
DWB97_RS09690	COG2195	Cleaves the N-terminal amino acid of tripeptides
DWB97_RS09695	COG1929	Belongs to the glycerate kinase type-1 family
DWB97_RS09715	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DWB97_RS09725	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DWB97_RS09730	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DWB97_RS09735	COG1780	Probably involved in ribonucleotide reductase function
DWB97_RS09745	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DWB97_RS09750	COG3104	oligopeptide transport
DWB97_RS09770	COG1174	glycine betaine transport
DWB97_RS09775	COG0517	IMP dehydrogenase activity
DWB97_RS09775	COG1125	glycine betaine transport
DWB97_RS09780	COG0514	ATP-dependent DNA helicase (RecQ)
DWB97_RS09785	COG0488	(ABC) transporter
DWB97_RS09795	COG1368	sulfuric ester hydrolase activity
DWB97_RS09815	COG0512	Glutamine amidotransferase of anthranilate synthase
DWB97_RS09815	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DWB97_RS09820	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DWB97_RS09820	COG0512	Glutamine amidotransferase of anthranilate synthase
DWB97_RS09830	COG0720	synthase
DWB97_RS09835	COG0602	queuosine metabolic process
DWB97_RS09865	COG0463	Glycosyl transferase, family 2
DWB97_RS09870	COG1253	flavin adenine dinucleotide binding
DWB97_RS09875	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DWB97_RS09875	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DWB97_RS09875	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DWB97_RS09880	COG1105	Belongs to the carbohydrate kinase PfkB family
DWB97_RS09885	COG1349	DNA-binding transcription factor activity
DWB97_RS09890	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DWB97_RS09895	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DWB97_RS09915	COG1266	CAAX protease self-immunity
DWB97_RS09920	COG0039	L-malate dehydrogenase activity
DWB97_RS09930	COG4989	oxidoreductase activity
DWB97_RS09935	COG0523	cobalamin synthesis protein
DWB97_RS09950	COG4988	ABC transporter
DWB97_RS09955	COG1968	undecaprenyl-diphosphatase activity
DWB97_RS09975	COG1671	Belongs to the UPF0178 family
DWB97_RS09980	COG1611	Belongs to the LOG family
DWB97_RS10010	COG2839	Protein conserved in bacteria
DWB97_RS10015	COG2814	Major facilitator Superfamily
DWB97_RS10020	COG0583	DNA-binding transcription factor activity
DWB97_RS10030	COG0217	transcriptional regulatory protein
DWB97_RS10040	COG2022	thiamine diphosphate biosynthetic process
DWB97_RS10050	COG0352	thiamine-phosphate diphosphorylase activity
DWB97_RS10060	COG3942	CHAP domain
DWB97_RS10060	COG1388	LysM domain
DWB97_RS10065	COG0306	phosphate transporter
DWB97_RS10070	COG1392	Phosphate transport regulator
DWB97_RS10075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DWB97_RS10090	COG3949	Membrane
DWB97_RS10095	COG0477	Major facilitator Superfamily
DWB97_RS10105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWB97_RS10110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWB97_RS10115	COG1120	ATPase activity
DWB97_RS10120	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DWB97_RS10125	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DWB97_RS10145	COG1132	(ABC) transporter
DWB97_RS10150	COG1686	Belongs to the peptidase S11 family
DWB97_RS10155	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DWB97_RS10160	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DWB97_RS10165	COG1682	transport, permease protein
DWB97_RS10170	COG1134	teichoic acid transport
DWB97_RS10175	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
DWB97_RS10180	COG0110	maltose O-acetyltransferase activity
DWB97_RS10190	COG1321	iron dependent repressor
DWB97_RS10195	COG1121	(ABC) transporter
DWB97_RS10200	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DWB97_RS10205	COG0803	Belongs to the bacterial solute-binding protein 9 family
DWB97_RS10210	COG1320	monovalent cation:proton antiporter activity
DWB97_RS10215	COG2212	antiporter activity
DWB97_RS10220	COG1863	multisubunit Na H antiporter MnhE subunit
DWB97_RS10225	COG0651	ATP synthesis coupled electron transport
DWB97_RS10230	COG1006	Multisubunit Na H antiporter MnhC subunit
DWB97_RS10235	COG2111	Na H antiporter
DWB97_RS10240	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DWB97_RS10240	COG2111	Na H antiporter
DWB97_RS10245	COG0582	viral genome integration into host DNA
DWB97_RS10280	COG0596	Alpha beta hydrolase
DWB97_RS10305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWB97_RS10310	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DWB97_RS10330	COG1078	dGTPase activity
DWB97_RS10340	COG0655	NAD(P)H dehydrogenase (quinone) activity
DWB97_RS10345	COG4844	belongs to the
DWB97_RS10350	COG0471	metal ion transport
DWB97_RS10365	COG0531	amino acid
DWB97_RS10375	COG0280	phosphate acetyltransferase
DWB97_RS10380	COG0095	Lipoate-protein ligase
DWB97_RS10385	COG2814	Major facilitator Superfamily
DWB97_RS10390	COG1566	PFAM secretion protein HlyD family protein
DWB97_RS10400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DWB97_RS10405	COG0531	amino acid
DWB97_RS10410	COG2363	Small membrane protein
DWB97_RS10420	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DWB97_RS10440	COG0183	Belongs to the thiolase family
DWB97_RS10445	COG0318	PFAM AMP-dependent synthetase and ligase
DWB97_RS10455	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
DWB97_RS10460	COG0363	glucosamine-6-phosphate deaminase activity
DWB97_RS10470	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DWB97_RS10475	COG1469	GTP cyclohydrolase I activity
DWB97_RS10480	COG0431	NADPH-dependent FMN reductase
DWB97_RS10485	COG0561	phosphatase activity
DWB97_RS10495	COG1428	Deoxynucleoside kinase
DWB97_RS10500	COG1428	Deoxynucleoside kinase
DWB97_RS10505	COG0546	phosphoglycolate phosphatase activity
DWB97_RS10525	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DWB97_RS10535	COG1473	amidohydrolase
DWB97_RS10550	COG0049	tRNA binding
DWB97_RS10555	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DWB97_RS10565	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DWB97_RS10575	COG2813	Specifically methylates the guanine in position
DWB97_RS10585	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DWB97_RS10590	COG0081	regulation of translation
DWB97_RS10595	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DWB97_RS10605	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DWB97_RS10610	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DWB97_RS10625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DWB97_RS10630	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
DWB97_RS10635	COG0215	cysteine-tRNA ligase activity
DWB97_RS10660	COG4956	integral membrane protein (PIN domain superfamily)
DWB97_RS10665	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DWB97_RS10675	COG3869	Catalyzes the specific phosphorylation of arginine residues in
DWB97_RS10680	COG3880	PFAM UvrB UvrC protein
DWB97_RS10690	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DWB97_RS10700	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DWB97_RS10705	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DWB97_RS10795	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DWB97_RS10800	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DWB97_RS10805	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DWB97_RS10825	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DWB97_RS10830	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DWB97_RS10845	COG1098	S1 RNA binding domain
DWB97_RS10855	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DWB97_RS10860	COG3956	TIGRFAM MazG family protein
DWB97_RS10865	COG2244	polysaccharide biosynthetic process
DWB97_RS10870	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DWB97_RS10875	COG0193	aminoacyl-tRNA hydrolase activity
DWB97_RS10885	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DWB97_RS10890	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DWB97_RS10895	COG2088	sporulation resulting in formation of a cellular spore
DWB97_RS10900	COG0251	oxidation-reduction process
DWB97_RS10905	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DWB97_RS10910	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DWB97_RS10915	COG4466	Protein conserved in bacteria
DWB97_RS10920	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DWB97_RS10925	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DWB97_RS10930	COG0084	hydrolase, TatD family'
DWB97_RS10940	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DWB97_RS10945	COG2827	Endonuclease containing a URI domain
DWB97_RS10950	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DWB97_RS10960	COG1774	PSP1 C-terminal conserved region
DWB97_RS10965	COG0470	DNA polymerase III
DWB97_RS10970	COG3870	Protein conserved in bacteria
DWB97_RS10975	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DWB97_RS10980	COG1982	Orn Lys Arg decarboxylase major
DWB97_RS11005	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DWB97_RS11010	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DWB97_RS11015	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DWB97_RS11030	COG2188	Transcriptional regulator
DWB97_RS11035	COG0366	Alpha amylase catalytic
DWB97_RS11040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DWB97_RS11040	COG1263	PTS System
DWB97_RS11050	COG0493	'glutamate synthase
DWB97_RS11055	COG0069	glutamate synthase activity
DWB97_RS11055	COG0070	glutamate synthase
DWB97_RS11055	COG0067	glutamate synthase
DWB97_RS11090	COG1309	transcriptional regulator
DWB97_RS11125	COG1131	(ABC) transporter
DWB97_RS11145	COG1388	LysM domain
DWB97_RS11145	COG3942	CHAP domain
DWB97_RS11150	COG0626	cystathionine gamma-synthase activity
DWB97_RS11155	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DWB97_RS11165	COG2272	Belongs to the type-B carboxylesterase lipase family
DWB97_RS11170	COG0733	neurotransmitter:sodium symporter activity
DWB97_RS11175	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DWB97_RS11180	COG0574	Belongs to the PEP-utilizing enzyme family
DWB97_RS11180	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DWB97_RS11195	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DWB97_RS11200	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DWB97_RS11210	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DWB97_RS11225	COG2076	Multidrug Resistance protein
DWB97_RS11230	COG2076	Multidrug Resistance protein
DWB97_RS11250	COG1124	(ABC) transporter
DWB97_RS11255	COG0444	Belongs to the ABC transporter superfamily
DWB97_RS11260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DWB97_RS11265	COG0601	transmembrane transport
DWB97_RS11270	COG0747	negative chemotaxis
DWB97_RS11295	COG1011	Hydrolase
DWB97_RS11320	COG1846	Transcriptional regulator
DWB97_RS11325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DWB97_RS11340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DWB97_RS11345	COG1609	Transcriptional regulator
DWB97_RS11360	COG0519	Catalyzes the synthesis of GMP from XMP
DWB97_RS11360	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DWB97_RS11365	COG0517	IMP dehydrogenase activity
DWB97_RS11365	COG0516	GMP reductase activity
DWB97_RS11370	COG2233	PERMEase
DWB97_RS11375	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DWB97_RS11395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DWB97_RS11400	COG1823	symporter activity
DWB97_RS11405	COG0778	Nitroreductase
DWB97_RS11415	COG0450	alkyl hydroperoxide reductase
DWB97_RS11420	COG3634	alkyl hydroperoxide reductase activity
DWB97_RS11435	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DWB97_RS11445	COG5002	protein histidine kinase activity
DWB97_RS11445	COG3850	Histidine kinase
DWB97_RS11450	COG0745	RESPONSE REGULATOR receiver
DWB97_RS11460	COG1929	Belongs to the glycerate kinase type-1 family
DWB97_RS11485	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DWB97_RS11495	COG0360	Binds together with S18 to 16S ribosomal RNA
DWB97_RS11500	COG2910	NAD(P)H-binding
DWB97_RS11510	COG0012	GTP binding
DWB97_RS11515	COG4481	Protein conserved in bacteria
DWB97_RS11520	COG0668	transmembrane transport
DWB97_RS11525	COG1475	DNA binding
DWB97_RS11530	COG0626	cystathionine gamma-synthase activity
DWB97_RS11535	COG0626	cystathionine gamma-synthase activity
DWB97_RS11540	COG0646	methionine synthase
DWB97_RS11540	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DWB97_RS11555	COG1279	arginine transmembrane transporter activity
DWB97_RS11560	COG0829	nickel cation binding
DWB97_RS11570	COG0830	nickel cation binding
DWB97_RS11575	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
DWB97_RS11580	COG1966	Carbon starvation protein
DWB97_RS11585	COG2353	YceI-like domain
DWB97_RS11600	COG2388	GCN5-related N-acetyl-transferase
DWB97_RS11615	COG1846	Transcriptional regulator
DWB97_RS11620	COG0346	lactoylglutathione lyase activity
DWB97_RS11625	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DWB97_RS11630	COG0400	carboxylic ester hydrolase activity
DWB97_RS11635	COG1475	DNA binding
DWB97_RS11640	COG0357	Ribosomal RNA small subunit methyltransferase G
DWB97_RS11645	COG0445	tRNA wobble uridine modification
DWB97_RS11650	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DWB97_RS11655	COG0594	ribonuclease P activity