locus-tag	class	description
DWB92_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DWB92_RS00010	COG0592	DNA-directed DNA polymerase activity
DWB92_RS00015	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DWB92_RS00030	COG0187	DNA topoisomerase II activity
DWB92_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DWB92_RS00045	COG2986	histidine ammonia-lyase
DWB92_RS00050	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DWB92_RS00055	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DWB92_RS00065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DWB92_RS00070	COG4241	membrane
DWB92_RS00075	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
DWB92_RS00085	COG0305	Participates in initiation and elongation during chromosome replication
DWB92_RS00090	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DWB92_RS00110	COG0745	RESPONSE REGULATOR receiver
DWB92_RS00115	COG5002	protein histidine kinase activity
DWB92_RS00120	COG4863	YycH protein
DWB92_RS00130	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DWB92_RS00215	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DWB92_RS00260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DWB92_RS00280	COG0747	negative chemotaxis
DWB92_RS00290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DWB92_RS00295	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DWB92_RS00300	COG1124	(ABC) transporter
DWB92_RS00325	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
DWB92_RS00355	COG0789	Transcriptional regulator
DWB92_RS00365	COG0702	epimerase
DWB92_RS00370	COG2130	NADP-dependent
DWB92_RS00390	COG0702	epimerase
DWB92_RS00395	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
DWB92_RS00450	COG0667	Aldo Keto reductase
DWB92_RS00455	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DWB92_RS00470	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
DWB92_RS00480	COG2188	Transcriptional regulator
DWB92_RS00485	COG2222	sugar isomerase
DWB92_RS00490	COG3684	Belongs to the aldolase LacD family
DWB92_RS00500	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DWB92_RS00500	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
DWB92_RS00505	COG3715	PTS system
DWB92_RS00510	COG3716	PTS system mannose fructose sorbose family IID component
DWB92_RS00530	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
DWB92_RS00535	COG0039	L-malate dehydrogenase activity
DWB92_RS00540	COG1328	CTP reductase activity
DWB92_RS00545	COG0602	queuosine metabolic process
DWB92_RS00550	COG2814	Major facilitator Superfamily
DWB92_RS00590	COG4716	Myosin-crossreactive antigen
DWB92_RS00615	COG2723	6-phospho-beta-galactosidase activity
DWB92_RS00620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DWB92_RS00630	COG3655	Transcriptional regulator
DWB92_RS00635	COG2311	Membrane
DWB92_RS00645	COG2188	Transcriptional regulator
DWB92_RS00650	COG0813	purine-nucleoside phosphorylase activity
DWB92_RS00655	COG2814	Major facilitator Superfamily
DWB92_RS00675	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DWB92_RS00680	COG1401	restriction endodeoxyribonuclease activity
DWB92_RS00700	COG0415	Belongs to the DNA photolyase family
DWB92_RS00735	COG1174	glycine betaine transport
DWB92_RS00745	COG1174	glycine betaine transport
DWB92_RS00765	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DWB92_RS00785	COG2235	arginine
DWB92_RS00790	COG1438	arginine binding
DWB92_RS00795	COG2814	Major facilitator Superfamily
DWB92_RS00810	COG1755	Isoprenylcysteine carboxyl methyltransferase
DWB92_RS00815	COG1113	amino acid transport
DWB92_RS00825	COG1473	amidohydrolase
DWB92_RS00835	COG0745	RESPONSE REGULATOR receiver
DWB92_RS00840	COG2205	protein histidine kinase activity
DWB92_RS00845	COG1136	(ABC) transporter
DWB92_RS00855	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DWB92_RS00865	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DWB92_RS00875	COG1335	isochorismatase
DWB92_RS00890	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DWB92_RS00895	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DWB92_RS00900	COG0156	8-amino-7-oxononanoate synthase activity
DWB92_RS00910	COG1620	l-lactate permease
DWB92_RS00945	COG0438	transferase activity, transferring glycosyl groups
DWB92_RS00955	COG0384	phenazine biosynthesis protein PhzF
DWB92_RS00975	COG1136	(ABC) transporter
DWB92_RS00980	COG0563	adenylate kinase activity
DWB92_RS00990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DWB92_RS00995	COG0730	response to heat
DWB92_RS01000	COG1937	Protein conserved in bacteria
DWB92_RS01005	COG2210	Belongs to the sulfur carrier protein TusA family
DWB92_RS01010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DWB92_RS01015	COG1609	Transcriptional regulator
DWB92_RS01020	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DWB92_RS01025	COG1869	D-ribose catabolic process
DWB92_RS01030	COG1129	ABC transporter
DWB92_RS01035	COG1172	Belongs to the binding-protein-dependent transport system permease family
DWB92_RS01040	COG1879	ABC-type sugar transport system periplasmic component
DWB92_RS01045	COG2814	Major facilitator Superfamily
DWB92_RS01050	COG0583	DNA-binding transcription factor activity
DWB92_RS01055	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DWB92_RS01060	COG0025	NhaP-type Na H and K H
DWB92_RS01065	COG3314	Sporulation integral membrane protein YlbJ
DWB92_RS01075	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DWB92_RS01085	COG3037	sugar-specific permease SgaT UlaA
DWB92_RS01125	COG2814	Major facilitator Superfamily
DWB92_RS01130	COG1335	isochorismatase
DWB92_RS01175	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DWB92_RS01220	COG2814	Major facilitator Superfamily
DWB92_RS01225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DWB92_RS01245	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DWB92_RS01255	COG1115	amino acid carrier protein
DWB92_RS01265	COG0668	transmembrane transport
DWB92_RS01280	COG4195	phage-related replication protein
DWB92_RS01300	COG2843	Capsule synthesis protein
DWB92_RS01330	COG2205	protein histidine kinase activity
DWB92_RS01340	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
DWB92_RS01350	COG0586	Pfam SNARE associated Golgi protein
DWB92_RS01355	COG1785	Belongs to the alkaline phosphatase family
DWB92_RS01360	COG1785	Belongs to the alkaline phosphatase family
DWB92_RS01370	COG0494	nUDIX hydrolase
DWB92_RS01375	COG0513	Belongs to the DEAD box helicase family
DWB92_RS01395	COG1510	regulation of RNA biosynthetic process
DWB92_RS01400	COG1012	belongs to the aldehyde dehydrogenase family
DWB92_RS01405	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
DWB92_RS01420	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DWB92_RS01430	COG0107	imidazoleglycerol-phosphate synthase activity
DWB92_RS01445	COG0131	Imidazoleglycerol-phosphate dehydratase
DWB92_RS01450	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DWB92_RS01455	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DWB92_RS01490	COG2271	Major facilitator Superfamily
DWB92_RS01495	COG0529	Catalyzes the synthesis of activated sulfate
DWB92_RS01505	COG0730	response to heat
DWB92_RS01520	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DWB92_RS01525	COG0175	sulfate reduction
DWB92_RS01530	COG2376	Dihydroxyacetone kinase
DWB92_RS01535	COG1461	Dihydroxyacetone kinase
DWB92_RS01550	COG2824	Alkylphosphonate utilization operon protein PhnA
DWB92_RS01555	COG1012	belongs to the aldehyde dehydrogenase family
DWB92_RS01575	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DWB92_RS01575	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DWB92_RS01575	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DWB92_RS01580	COG1705	Flagellar rod assembly protein muramidase FlgJ
DWB92_RS01580	COG3942	CHAP domain
DWB92_RS01605	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DWB92_RS01610	COG0747	negative chemotaxis
DWB92_RS01635	COG0463	Glycosyl transferase, family 2
DWB92_RS01635	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DWB92_RS01660	COG1263	PTS System
DWB92_RS01660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DWB92_RS01690	COG3001	Fructosamine kinase
DWB92_RS01710	COG1136	(ABC) transporter
DWB92_RS01715	COG1136	(ABC) transporter
DWB92_RS01715	COG0577	efflux transmembrane transporter activity
DWB92_RS01725	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DWB92_RS01735	COG5002	protein histidine kinase activity
DWB92_RS01750	COG1811	Na channel or pump
DWB92_RS01755	COG4413	Urea transporter
DWB92_RS01765	COG0832	Belongs to the urease beta subunit family
DWB92_RS01770	COG0804	urea catabolic process
DWB92_RS01780	COG0523	cobalamin synthesis protein
DWB92_RS01790	COG1114	Component of the transport system for branched-chain amino acids
DWB92_RS01795	COG3189	MarR family transcriptional regulator
DWB92_RS01810	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWB92_RS01815	COG4605	iron ion homeostasis
DWB92_RS01820	COG4604	ABC transporter, ATP-binding protein
DWB92_RS01825	COG4607	ABC-type enterochelin transport system periplasmic component
DWB92_RS01835	COG1846	Transcriptional regulator
DWB92_RS01840	COG0778	Nitroreductase
DWB92_RS01845	COG2357	RelA SpoT domain protein
DWB92_RS01850	COG0739	heme binding
DWB92_RS01860	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DWB92_RS01885	COG2267	carboxylic ester hydrolase activity
DWB92_RS01890	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
DWB92_RS01895	COG2814	Major facilitator Superfamily
DWB92_RS01915	COG1028	Short-chain dehydrogenase reductase Sdr
DWB92_RS01920	COG0753	catalase activity
DWB92_RS01940	COG1028	Short-chain dehydrogenase reductase Sdr
DWB92_RS02005	COG3835	regulator
DWB92_RS02015	COG3961	Belongs to the TPP enzyme family
DWB92_RS02020	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DWB92_RS02025	COG0512	Glutamine amidotransferase of anthranilate synthase
DWB92_RS02030	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DWB92_RS02035	COG0134	indole-3-glycerol-phosphate synthase activity
DWB92_RS02040	COG0135	phosphoribosylanthranilate isomerase activity
DWB92_RS02045	COG0133	tryptophan synthase activity
DWB92_RS02050	COG0159	tryptophan synthase activity
DWB92_RS02055	COG1011	Hydrolase
DWB92_RS02080	COG0789	Transcriptional regulator
DWB92_RS02085	COG0346	lactoylglutathione lyase activity
DWB92_RS02095	COG1115	amino acid carrier protein
DWB92_RS02105	COG2814	Major facilitator Superfamily
DWB92_RS02110	COG2271	Major facilitator Superfamily
DWB92_RS02115	COG3764	Sortase (surface protein transpeptidase)
DWB92_RS02120	COG1929	Belongs to the glycerate kinase type-1 family
DWB92_RS02140	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DWB92_RS02150	COG0702	epimerase
DWB92_RS02160	COG3775	system Galactitol-specific IIC component
DWB92_RS02180	COG1760	l-serine dehydratase
DWB92_RS02185	COG1760	l-serine dehydratase
DWB92_RS02210	COG3201	nicotinamide mononucleotide transporter
DWB92_RS02215	COG0471	metal ion transport
DWB92_RS02230	COG0454	-acetyltransferase
DWB92_RS02245	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DWB92_RS02250	COG2146	nitrite reductase [NAD(P)H] activity
DWB92_RS02260	COG0737	Belongs to the 5'-nucleotidase family
DWB92_RS02265	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
DWB92_RS02270	COG1140	nitrate reductase beta subunit
DWB92_RS02275	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
DWB92_RS02280	COG2181	nitrate reductase activity
DWB92_RS02290	COG4585	Histidine kinase
DWB92_RS02295	COG2197	response regulator
DWB92_RS02300	COG2223	nitrite transmembrane transporter activity
DWB92_RS02305	COG4187	Peptidase family M20/M25/M40
DWB92_RS02315	COG1363	Peptidase, m42
DWB92_RS02340	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DWB92_RS02355	COG1846	Transcriptional regulator
DWB92_RS02360	COG1283	sodium-dependent phosphate transmembrane transporter activity
DWB92_RS02385	COG0492	ferredoxin-NADP+ reductase activity
DWB92_RS02390	COG2814	Major facilitator Superfamily
DWB92_RS02395	COG0604	alcohol dehydrogenase
DWB92_RS02410	COG1620	l-lactate permease
DWB92_RS02420	COG0579	oxidoreductase
DWB92_RS02435	COG0577	efflux transmembrane transporter activity
DWB92_RS02445	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
DWB92_RS02480	COG0657	acetylesterase activity
DWB92_RS02495	COG1304	FMN binding
DWB92_RS02500	COG0523	cobalamin synthesis protein
DWB92_RS02505	COG0786	glutamate:sodium symporter activity
DWB92_RS02510	COG2207	Transcriptional regulator
DWB92_RS02520	COG1757	Na H antiporter
DWB92_RS02525	COG2094	Belongs to the DNA glycosylase MPG family
DWB92_RS02530	COG3152	Membrane
DWB92_RS02535	COG4152	abc transporter atp-binding protein
DWB92_RS02540	COG1668	transmembrane transport
DWB92_RS02545	COG1742	UPF0060 membrane protein
DWB92_RS02550	COG1476	TRANSCRIPTIONal
DWB92_RS02560	COG2258	MOSC domain
DWB92_RS02565	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DWB92_RS02570	COG1266	CAAX protease self-immunity
DWB92_RS02580	COG0583	DNA-binding transcription factor activity
DWB92_RS02585	COG3314	Sporulation integral membrane protein YlbJ
DWB92_RS02590	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DWB92_RS02595	COG1228	amidohydrolase
DWB92_RS02605	COG1473	amidohydrolase
DWB92_RS02625	COG0385	Bile acid
DWB92_RS02635	COG0346	lactoylglutathione lyase activity
DWB92_RS02640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DWB92_RS02660	COG1113	amino acid transport
DWB92_RS02665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DWB92_RS02665	COG1263	PTS System
DWB92_RS02670	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DWB92_RS02695	COG0483	inositol monophosphate 1-phosphatase activity
DWB92_RS02700	COG1316	TRANSCRIPTIONal
DWB92_RS02710	COG3383	formate dehydrogenase (NAD+) activity
DWB92_RS02740	COG3942	CHAP domain
DWB92_RS02765	COG3942	CHAP domain
DWB92_RS02790	COG1960	acyl-CoA dehydrogenase activity
DWB92_RS02795	COG2832	Protein of unknown function (DUF454)
DWB92_RS02800	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DWB92_RS02805	COG1268	BioY protein
DWB92_RS02820	COG0725	ABC transporter, periplasmic molybdate-binding protein
DWB92_RS02825	COG4149	molybdate abc transporter
DWB92_RS02830	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DWB92_RS02835	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DWB92_RS02840	COG0521	Mo-molybdopterin cofactor biosynthetic process
DWB92_RS02845	COG0315	cyclic pyranopterin monophosphate synthase activity
DWB92_RS02870	COG0746	molybdenum cofactor guanylyltransferase activity
DWB92_RS02875	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DWB92_RS02900	COG2348	transferase activity, transferring amino-acyl groups
DWB92_RS02905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DWB92_RS02935	COG2252	PERMEase
DWB92_RS02945	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DWB92_RS02950	COG0088	Forms part of the polypeptide exit tunnel
DWB92_RS02955	COG0089	rRNA binding
DWB92_RS02960	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DWB92_RS02965	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DWB92_RS02985	COG0255	Belongs to the universal ribosomal protein uL29 family
DWB92_RS02995	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DWB92_RS03000	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DWB92_RS03010	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DWB92_RS03030	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DWB92_RS03035	COG1841	ribosomal large subunit assembly
DWB92_RS03045	COG0201	protein transport
DWB92_RS03060	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DWB92_RS03070	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DWB92_RS03075	COG0202	RNA polymerase activity
DWB92_RS03080	COG0203	ribosomal protein L17
DWB92_RS03085	COG1122	ATPase activity
DWB92_RS03090	COG1122	ATPase activity
DWB92_RS03145	COG2723	6-phospho-beta-galactosidase activity
DWB92_RS03150	COG0604	alcohol dehydrogenase
DWB92_RS03155	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DWB92_RS03165	COG2814	Major facilitator Superfamily
DWB92_RS03170	COG4264	IucA IucC family
DWB92_RS03175	COG2814	Major facilitator Superfamily
DWB92_RS03180	COG4264	IucA IucC family
DWB92_RS03185	COG3457	Alanine racemase
DWB92_RS03190	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DWB92_RS03195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWB92_RS03200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWB92_RS03210	COG1988	membrane-bound metal-dependent
DWB92_RS03215	COG4284	Utp--glucose-1-phosphate uridylyltransferase
DWB92_RS03240	COG2814	Major facilitator Superfamily
DWB92_RS03310	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DWB92_RS03315	COG0246	Mannitol dehydrogenase
DWB92_RS03330	COG1119	ATPase activity
DWB92_RS03345	COG2186	Transcriptional regulator
DWB92_RS03365	COG1757	Na H antiporter
DWB92_RS03410	COG5146	pantothenate kinase activity
DWB92_RS03445	COG0191	fructose-bisphosphate aldolase activity
DWB92_RS03450	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DWB92_RS03455	COG1733	regulation of RNA biosynthetic process
DWB92_RS03470	COG0254	rRNA binding
DWB92_RS03475	COG1435	thymidine kinase activity
DWB92_RS03480	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DWB92_RS03485	COG2890	protein-(glutamine-N5) methyltransferase activity
DWB92_RS03490	COG0009	L-threonylcarbamoyladenylate synthase
DWB92_RS03500	COG4475	Protein of unknown function (DUF436)
DWB92_RS03510	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DWB92_RS03515	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DWB92_RS03525	COG0356	it plays a direct role in the translocation of protons across the membrane
DWB92_RS03530	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DWB92_RS03535	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DWB92_RS03540	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DWB92_RS03550	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DWB92_RS03570	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DWB92_RS03580	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DWB92_RS03605	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DWB92_RS03615	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DWB92_RS03620	COG0352	thiamine-phosphate diphosphorylase activity
DWB92_RS03625	COG0706	membrane insertase activity
DWB92_RS03630	COG1418	mRNA catabolic process
DWB92_RS03640	COG1937	Protein conserved in bacteria
DWB92_RS03650	COG2608	mercury ion transmembrane transporter activity
DWB92_RS03655	COG2217	Heavy metal translocating P-type atpase
DWB92_RS03660	COG0772	Belongs to the SEDS family
DWB92_RS03665	COG1181	Belongs to the D-alanine--D-alanine ligase family
DWB92_RS03670	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DWB92_RS03675	COG0513	Belongs to the DEAD box helicase family
DWB92_RS03695	COG0736	holo-[acyl-carrier-protein] synthase activity
DWB92_RS03710	COG2337	Toxic component of a toxin-antitoxin (TA) module
DWB92_RS03715	COG2208	phosphoserine phosphatase activity
DWB92_RS03730	COG1191	sigma factor activity
DWB92_RS03770	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DWB92_RS03775	COG0066	3-isopropylmalate dehydratase activity
DWB92_RS03785	COG0473	3-isopropylmalate dehydrogenase activity
DWB92_RS03790	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DWB92_RS03805	COG0028	Belongs to the TPP enzyme family
DWB92_RS03815	COG0802	atpase or kinase
DWB92_RS03820	COG1214	PFAM Peptidase M22, glycoprotease
DWB92_RS03825	COG0456	acetyltransferase
DWB92_RS03830	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DWB92_RS03840	COG0488	(ABC) transporter
DWB92_RS03850	COG2391	methyltransferase activity
DWB92_RS03855	COG0425	Belongs to the sulfur carrier protein TusA family
DWB92_RS03860	COG1621	beta-fructofuranosidase activity
DWB92_RS03880	COG4512	PFAM Accessory gene regulator B
DWB92_RS03900	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DWB92_RS03925	COG3617	BRO family, N-terminal domain
DWB92_RS03995	COG3728	DNA packaging
DWB92_RS03995	COG5484	DNA packaging
DWB92_RS04010	COG1307	EDD domain protein, DegV family
DWB92_RS04060	COG1131	(ABC) transporter
DWB92_RS04070	COG1802	Transcriptional regulator
DWB92_RS04075	COG1070	Carbohydrate kinase
DWB92_RS04080	COG2610	gluconate transmembrane transporter activity
DWB92_RS04085	COG4876	unkown
DWB92_RS04125	COG1012	belongs to the aldehyde dehydrogenase family
DWB92_RS04135	COG1227	inorganic diphosphatase activity
DWB92_RS04150	COG0077	Prephenate dehydratase
DWB92_RS04165	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DWB92_RS04170	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
DWB92_RS04185	COG4496	protein, YerC YecD
DWB92_RS04190	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
DWB92_RS04195	COG0210	DNA helicase
DWB92_RS04200	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DWB92_RS04205	COG4851	CamS sex pheromone cAM373 precursor
DWB92_RS04210	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DWB92_RS04215	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DWB92_RS04230	COG1597	lipid kinase activity
DWB92_RS04235	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DWB92_RS04250	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DWB92_RS04260	COG1528	Iron-storage protein
DWB92_RS04275	COG4129	membrane
DWB92_RS04280	COG0024	Methionine aminopeptidase
DWB92_RS04305	COG0288	reversible hydration of carbon dioxide
DWB92_RS04310	COG1295	ribonuclease BN
DWB92_RS04320	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DWB92_RS04325	COG4840	Belongs to the UPF0435 family
DWB92_RS04330	COG2309	aminopeptidase activity
DWB92_RS04335	COG1607	acyl-coa hydrolase
DWB92_RS04340	COG0535	radical SAM domain protein
DWB92_RS04345	COG0693	protein deglycase activity
DWB92_RS04350	COG0028	Belongs to the TPP enzyme family
DWB92_RS04355	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DWB92_RS04360	COG2137	regulation of response to DNA damage stimulus
DWB92_RS04370	COG1134	teichoic acid transport
DWB92_RS04370	COG1388	LysM domain
DWB92_RS04380	COG1988	membrane-bound metal-dependent
DWB92_RS04385	COG1194	a g-specific adenine glycosylase
DWB92_RS04390	COG3557	Belongs to the UPF0374 family
DWB92_RS04400	COG0069	glutamate synthase activity
DWB92_RS04405	COG4129	membrane
DWB92_RS04410	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DWB92_RS04415	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DWB92_RS04420	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DWB92_RS04425	COG0735	belongs to the Fur family
DWB92_RS04590	COG0765	amino acid transport
DWB92_RS04595	COG1126	abc transporter atp-binding protein
DWB92_RS04600	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DWB92_RS04605	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DWB92_RS04610	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DWB92_RS04615	COG0363	glucosamine-6-phosphate deaminase activity
DWB92_RS04625	COG0114	fumarate hydratase activity
DWB92_RS04635	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DWB92_RS04645	COG4585	Histidine kinase
DWB92_RS04645	COG2203	Gaf domain
DWB92_RS04650	COG2197	response regulator
DWB92_RS04660	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DWB92_RS04675	COG1301	dicarboxylic acid transport
DWB92_RS04715	COG3679	Belongs to the UPF0342 family
DWB92_RS04720	COG0420	3'-5' exonuclease activity
DWB92_RS04730	COG3481	metal-dependent phosphohydrolase, HD sub domain
DWB92_RS04745	COG1846	Transcriptional regulator
DWB92_RS04755	COG0537	adenosine 5'-monophosphoramidase activity
DWB92_RS04760	COG1131	(ABC) transporter
DWB92_RS04775	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DWB92_RS04780	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DWB92_RS04860	COG1396	sequence-specific DNA binding
DWB92_RS04870	COG3561	AntA/AntB antirepressor
DWB92_RS04910	COG0629	single-stranded DNA binding
DWB92_RS04940	COG0305	Participates in initiation and elongation during chromosome replication
DWB92_RS05085	COG0739	heme binding
DWB92_RS05170	COG1028	Short-chain dehydrogenase reductase Sdr
DWB92_RS05185	COG1302	Protein conserved in bacteria
DWB92_RS05190	COG0318	PFAM AMP-dependent synthetase and ligase
DWB92_RS05200	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DWB92_RS05210	COG1506	peptidase
DWB92_RS05215	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
DWB92_RS05220	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DWB92_RS05230	COG0656	L-ascorbic acid biosynthetic process
DWB92_RS05235	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DWB92_RS05240	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DWB92_RS05250	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DWB92_RS05275	COG3266	domain, Protein
DWB92_RS05275	COG4193	domain, Protein
DWB92_RS05275	COG5632	N-Acetylmuramoyl-L-alanine amidase
DWB92_RS05285	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DWB92_RS05285	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DWB92_RS05300	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DWB92_RS05305	COG0506	proline dehydrogenase activity
DWB92_RS05315	COG2267	carboxylic ester hydrolase activity
DWB92_RS05320	COG0039	L-malate dehydrogenase activity
DWB92_RS05330	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DWB92_RS05335	COG1242	4 iron, 4 sulfur cluster binding
DWB92_RS05345	COG0495	leucyl-tRNA aminoacylation
DWB92_RS05350	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DWB92_RS05355	COG2081	HI0933 family
DWB92_RS05360	COG2244	polysaccharide biosynthetic process
DWB92_RS05365	COG1187	pseudouridine synthase activity
DWB92_RS05375	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DWB92_RS05380	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DWB92_RS05390	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DWB92_RS05395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DWB92_RS05405	COG1363	Peptidase, m42
DWB92_RS05410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DWB92_RS05420	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DWB92_RS05430	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DWB92_RS05435	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
DWB92_RS05445	COG1605	Chorismate mutase
DWB92_RS05445	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DWB92_RS05450	COG1609	Transcriptional regulator
DWB92_RS05455	COG0123	including yeast histone deacetylase and acetoin utilization protein
DWB92_RS05465	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DWB92_RS05470	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DWB92_RS05475	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DWB92_RS05485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DWB92_RS05500	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DWB92_RS05505	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DWB92_RS05510	COG1764	response to oxidative stress
DWB92_RS05515	COG0584	glycerophosphoryl diester phosphodiesterase
DWB92_RS05525	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DWB92_RS05530	COG1956	GAF domain-containing protein
DWB92_RS05535	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
DWB92_RS05540	COG1104	cysteine desulfurase activity
DWB92_RS05545	COG0301	tRNA thio-modification
DWB92_RS05550	COG0730	response to heat
DWB92_RS05565	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DWB92_RS05570	COG0589	response to stress
DWB92_RS05585	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DWB92_RS05595	COG4109	DRTGG domain
DWB92_RS05600	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DWB92_RS05605	COG0587	DNA-directed DNA polymerase activity
DWB92_RS05610	COG0281	malic enzyme
DWB92_RS05615	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DWB92_RS05620	COG0825	malonyl-CoA metabolic process
DWB92_RS05625	COG0205	6-phosphofructokinase activity
DWB92_RS05640	COG0538	isocitrate dehydrogenase activity
DWB92_RS05645	COG0745	RESPONSE REGULATOR receiver
DWB92_RS05655	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DWB92_RS05655	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DWB92_RS05660	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DWB92_RS05665	COG0237	dephospho-CoA kinase activity
DWB92_RS05680	COG3611	Membrane attachment protein
DWB92_RS05685	COG1484	DNA-dependent DNA replication
DWB92_RS05690	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DWB92_RS05700	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DWB92_RS05705	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DWB92_RS05730	COG0544	peptidyl-prolyl cis-trans isomerase activity
DWB92_RS05740	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DWB92_RS05745	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DWB92_RS05750	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DWB92_RS05755	COG0181	hydroxymethylbilane synthase activity
DWB92_RS05780	COG2818	Glycosylase
DWB92_RS05785	COG0525	valine-tRNA ligase activity
DWB92_RS05790	COG0285	dihydrofolate synthase activity
DWB92_RS05800	COG2003	Belongs to the UPF0758 family
DWB92_RS05820	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DWB92_RS05825	COG2868	ribosomal protein
DWB92_RS05830	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DWB92_RS05840	COG4492	Belongs to the UPF0735 family
DWB92_RS05850	COG2255	four-way junction helicase activity
DWB92_RS05865	COG1862	Preprotein translocase
DWB92_RS05880	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DWB92_RS05890	COG1490	D-aminoacyl-tRNA deacylase activity
DWB92_RS05900	COG0124	histidyl-tRNA synthetase
DWB92_RS05915	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DWB92_RS05920	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DWB92_RS05925	COG1959	2 iron, 2 sulfur cluster binding
DWB92_RS05935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWB92_RS05940	COG1104	cysteine desulfurase activity
DWB92_RS05945	COG0482	sulfurtransferase activity
DWB92_RS05955	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DWB92_RS05965	COG4472	Bacterial protein of unknown function (DUF965)
DWB92_RS05970	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DWB92_RS05975	COG3906	Belongs to the UPF0473 family
DWB92_RS05980	COG4122	O-methyltransferase activity
DWB92_RS05990	COG0826	peptidase U32
DWB92_RS05995	COG0572	uridine kinase
DWB92_RS06000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DWB92_RS06005	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DWB92_RS06010	COG1984	allophanate hydrolase subunit 2
DWB92_RS06015	COG0511	ligase activity, forming carbon-carbon bonds
DWB92_RS06020	COG0439	Biotin carboxylase
DWB92_RS06025	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DWB92_RS06030	COG1914	H( )-stimulated, divalent metal cation uptake system
DWB92_RS06035	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DWB92_RS06040	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
DWB92_RS06045	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DWB92_RS06055	COG1534	Rna-binding protein
DWB92_RS06065	COG1713	HD superfamily hydrolase involved in NAD metabolism
DWB92_RS06070	COG0799	negative regulation of ribosome biogenesis
DWB92_RS06075	COG2226	methyltransferase
DWB92_RS06080	COG1596	polysaccharide export
DWB92_RS06080	COG1555	photosystem II stabilization
DWB92_RS06085	COG2131	deaminase
DWB92_RS06090	COG2333	competence protein COMEC
DWB92_RS06090	COG0658	competence protein
DWB92_RS06095	COG1466	dna polymerase III delta subunit
DWB92_RS06100	COG0268	Binds directly to 16S ribosomal RNA
DWB92_RS06110	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DWB92_RS06115	COG1420	regulation of RNA biosynthetic process
DWB92_RS06120	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DWB92_RS06125	COG0443	Heat shock 70 kDa protein
DWB92_RS06130	COG0484	heat shock protein binding
DWB92_RS06140	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DWB92_RS06145	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DWB92_RS06155	COG1030	water channel activity
DWB92_RS06160	COG4864	UPF0365 protein
DWB92_RS06175	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DWB92_RS06185	COG0295	cytidine deaminase activity
DWB92_RS06195	COG1381	Involved in DNA repair and RecF pathway recombination
DWB92_RS06200	COG0423	glycine-tRNA ligase activity
DWB92_RS06205	COG0517	IMP dehydrogenase activity
DWB92_RS06210	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DWB92_RS06215	COG0358	DNA primase activity
DWB92_RS06220	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DWB92_RS06225	COG2384	SAM-dependent methyltransferase
DWB92_RS06230	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DWB92_RS06235	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DWB92_RS06250	COG1121	(ABC) transporter
DWB92_RS06255	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DWB92_RS06265	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DWB92_RS06275	COG0768	penicillin binding
DWB92_RS06280	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DWB92_RS06285	COG0573	inorganic phosphate transmembrane transporter activity
DWB92_RS06290	COG0581	inorganic phosphate transmembrane transporter activity
DWB92_RS06295	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DWB92_RS06300	COG0704	Plays a role in the regulation of phosphate uptake
DWB92_RS06305	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DWB92_RS06310	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DWB92_RS06315	COG0705	Rhomboid family
DWB92_RS06315	COG0457	Tetratricopeptide repeat
DWB92_RS06320	COG4483	Protein conserved in bacteria
DWB92_RS06325	COG1940	carbohydrate kinase activity
DWB92_RS06330	COG0011	TIGRFAM Protein of
DWB92_RS06335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DWB92_RS06340	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DWB92_RS06345	COG1459	type II secretion system
DWB92_RS06350	COG4537	Required for transformation and DNA binding
DWB92_RS06370	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DWB92_RS06375	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DWB92_RS06380	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DWB92_RS06385	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DWB92_RS06390	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DWB92_RS06395	COG0095	Lipoate-protein ligase
DWB92_RS06410	COG0006	proline dipeptidase activity
DWB92_RS06415	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DWB92_RS06420	COG0511	ligase activity, forming carbon-carbon bonds
DWB92_RS06425	COG0439	Biotin carboxylase
DWB92_RS06435	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DWB92_RS06445	COG1722	exodeoxyribonuclease VII activity
DWB92_RS06455	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DWB92_RS06460	COG1438	arginine binding
DWB92_RS06465	COG0497	DNA recombination
DWB92_RS06470	COG0280	phosphate acetyltransferase
DWB92_RS06480	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DWB92_RS06485	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DWB92_RS06490	COG0022	dehydrogenase e1 component
DWB92_RS06505	COG4129	membrane
DWB92_RS06510	COG2195	Cleaves the N-terminal amino acid of tripeptides
DWB92_RS06525	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DWB92_RS06530	COG1234	tRNA 3'-trailer cleavage
DWB92_RS06535	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DWB92_RS06540	COG0667	Aldo Keto reductase
DWB92_RS06545	COG0494	nUDIX hydrolase
DWB92_RS06550	COG0735	belongs to the Fur family
DWB92_RS06555	COG4974	Belongs to the 'phage' integrase family
DWB92_RS06565	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DWB92_RS06570	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DWB92_RS06575	COG1187	pseudouridine synthase activity
DWB92_RS06580	COG0745	RESPONSE REGULATOR receiver
DWB92_RS06595	COG1141	Ferredoxin
DWB92_RS06605	COG0514	ATP-dependent DNA helicase (RecQ)
DWB92_RS06615	COG0492	ferredoxin-NADP+ reductase activity
DWB92_RS06625	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DWB92_RS06655	COG2226	methyltransferase
DWB92_RS06660	COG0142	geranyltranstransferase activity
DWB92_RS06665	COG0105	UTP biosynthetic process
DWB92_RS06670	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DWB92_RS06675	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DWB92_RS06680	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DWB92_RS06685	COG0457	Tetratricopeptide repeat
DWB92_RS06690	COG5582	Belongs to the UPF0302 family
DWB92_RS06695	COG4347	Protein of unknown function (DUF1405)
DWB92_RS06700	COG2738	Putative neutral zinc metallopeptidase
DWB92_RS06710	COG0438	transferase activity, transferring glycosyl groups
DWB92_RS06715	COG0617	tRNA 3'-terminal CCA addition
DWB92_RS06735	COG3935	DnaD domain protein
DWB92_RS06740	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DWB92_RS06750	COG4499	WXG100 protein secretion system (Wss), protein YukC
DWB92_RS06750	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DWB92_RS06755	COG3331	DNA recombination
DWB92_RS06765	COG4474	Belongs to the UPF0398 family
DWB92_RS06770	COG3599	regulation of cell shape
DWB92_RS06780	COG0116	Belongs to the methyltransferase superfamily
DWB92_RS06785	COG2962	Rard protein
DWB92_RS06790	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DWB92_RS06795	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DWB92_RS06805	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DWB92_RS06815	COG1413	lyase activity
DWB92_RS06825	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DWB92_RS06845	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DWB92_RS06855	COG4479	Belongs to the UPF0346 family
DWB92_RS06885	COG5002	protein histidine kinase activity
DWB92_RS06890	COG0567	Dehydrogenase, E1 component
DWB92_RS06910	COG0714	Associated with various cellular activities
DWB92_RS06920	COG1114	Component of the transport system for branched-chain amino acids
DWB92_RS06925	COG3853	Toxic anion resistance protein (TelA)
DWB92_RS06945	COG1278	Cold shock
DWB92_RS06960	COG1473	amidohydrolase
DWB92_RS06965	COG2171	N-acyltransferase activity
DWB92_RS06970	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DWB92_RS06975	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DWB92_RS06980	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DWB92_RS06990	COG2996	Protein conserved in bacteria
DWB92_RS07000	COG1164	Oligoendopeptidase f
DWB92_RS07015	COG2348	transferase activity, transferring amino-acyl groups
DWB92_RS07020	COG0287	Prephenate dehydrogenase
DWB92_RS07025	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DWB92_RS07055	COG0628	permease
DWB92_RS07065	COG3711	transcriptional antiterminator
DWB92_RS07070	COG1115	amino acid carrier protein
DWB92_RS07075	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DWB92_RS07090	COG4841	protein insertion into membrane
DWB92_RS07095	COG0824	Thioesterase
DWB92_RS07110	COG1970	mechanosensitive ion channel activity
DWB92_RS07115	COG0419	ATPase involved in DNA repair
DWB92_RS07125	COG4846	Membrane protein involved in cytochrome C biogenesis
DWB92_RS07130	COG3763	UPF0154 protein
DWB92_RS07140	COG4224	UPF0291 protein
DWB92_RS07150	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DWB92_RS07160	COG0516	GMP reductase activity
DWB92_RS07165	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DWB92_RS07175	COG0753	catalase activity
DWB92_RS07180	COG0833	amino acid
DWB92_RS07190	COG0561	phosphatase activity
DWB92_RS07195	COG0083	homoserine kinase activity
DWB92_RS07205	COG0460	homoserine dehydrogenase
DWB92_RS07210	COG0527	aspartate kinase activity
DWB92_RS07240	COG4585	Histidine kinase
DWB92_RS07250	COG4172	Belongs to the ABC transporter superfamily
DWB92_RS07275	COG0789	Transcriptional regulator
DWB92_RS07280	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
DWB92_RS07285	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DWB92_RS07290	COG0386	Belongs to the glutathione peroxidase family
DWB92_RS07295	COG1923	regulation of RNA biosynthetic process
DWB92_RS07310	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DWB92_RS07320	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DWB92_RS07325	COG1619	proteins homologs of microcin C7 resistance protein MccF
DWB92_RS07335	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DWB92_RS07365	COG1013	pyruvate-flavodoxin oxidoreductase activity
DWB92_RS07370	COG0674	pyruvate-flavodoxin oxidoreductase activity
DWB92_RS07370	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DWB92_RS07375	COG1692	metallophosphoesterase
DWB92_RS07395	COG1418	mRNA catabolic process
DWB92_RS07400	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DWB92_RS07405	COG1058	Belongs to the CinA family
DWB92_RS07405	COG1546	Belongs to the CinA family
DWB92_RS07425	COG0300	oxidoreductase activity
DWB92_RS07435	COG0612	Peptidase, M16
DWB92_RS07440	COG2188	Transcriptional regulator
DWB92_RS07460	COG1185	polyribonucleotide nucleotidyltransferase activity
DWB92_RS07470	COG0196	riboflavin kinase activity
DWB92_RS07475	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DWB92_RS07480	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DWB92_RS07495	COG1358	cellular component organization or biogenesis
DWB92_RS07500	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DWB92_RS07505	COG0195	Participates in both transcription termination and antitermination
DWB92_RS07510	COG0779	Required for maturation of 30S ribosomal subunits
DWB92_RS07530	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DWB92_RS07535	COG4589	Belongs to the CDS family
DWB92_RS07540	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DWB92_RS07545	COG0233	cytoplasmic translational termination
DWB92_RS07550	COG0528	UMP kinase activity
DWB92_RS07555	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DWB92_RS07560	COG0052	Belongs to the universal ribosomal protein uS2 family
DWB92_RS07565	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
DWB92_RS07580	COG4974	Belongs to the 'phage' integrase family
DWB92_RS07585	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DWB92_RS07590	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DWB92_RS07595	COG0758	DNA mediated transformation
DWB92_RS07615	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DWB92_RS07630	COG4485	Bacterial membrane protein, YfhO
DWB92_RS07640	COG0671	phosphoesterase, PA-phosphatase related
DWB92_RS07645	COG0335	large ribosomal subunit rRNA binding
DWB92_RS07650	COG0336	Belongs to the RNA methyltransferase TrmD family
DWB92_RS07660	COG0228	four-way junction DNA binding
DWB92_RS07665	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DWB92_RS07670	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
DWB92_RS07690	COG0571	ribonuclease III activity
DWB92_RS07695	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DWB92_RS07700	COG1028	Short-chain dehydrogenase reductase Sdr
DWB92_RS07715	COG1349	DNA-binding transcription factor activity
DWB92_RS07725	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DWB92_RS07730	COG1760	l-serine dehydratase
DWB92_RS07735	COG1760	l-serine dehydratase
DWB92_RS07745	COG1302	Protein conserved in bacteria
DWB92_RS07755	COG1564	THIamine pyrophosphokinase
DWB92_RS07760	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DWB92_RS07765	COG1162	GTPase activity
DWB92_RS07770	COG2124	cytochrome p450
DWB92_RS07785	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DWB92_RS07790	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DWB92_RS07790	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DWB92_RS07795	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DWB92_RS07800	COG0242	peptide deformylase activity
DWB92_RS07805	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DWB92_RS07810	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DWB92_RS07815	COG1758	RNA polymerase activity
DWB92_RS07835	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DWB92_RS07845	COG0167	dihydroorotate dehydrogenase activity
DWB92_RS07850	COG0543	2 iron, 2 sulfur cluster binding
DWB92_RS07870	COG0540	Belongs to the ATCase OTCase family
DWB92_RS07880	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DWB92_RS07885	COG0564	pseudouridine synthase activity
DWB92_RS07890	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DWB92_RS07920	COG1799	cell septum assembly
DWB92_RS07925	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DWB92_RS07930	COG1496	oxidoreductase activity
DWB92_RS07935	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DWB92_RS07940	COG0849	cell division
DWB92_RS07950	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DWB92_RS07970	COG0275	rRNA processing
DWB92_RS07975	COG2001	Belongs to the MraZ family
DWB92_RS07985	COG0454	-acetyltransferase
DWB92_RS08010	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DWB92_RS08065	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DWB92_RS08070	COG1053	succinate dehydrogenase
DWB92_RS08075	COG2009	succinate dehydrogenase
DWB92_RS08080	COG0322	excinuclease ABC activity
DWB92_RS08085	COG3118	belongs to the thioredoxin family
DWB92_RS08090	COG1193	negative regulation of DNA recombination
DWB92_RS08095	COG1796	DNA polymerase
DWB92_RS08095	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DWB92_RS08105	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
DWB92_RS08115	COG0072	phenylalanine-tRNA ligase activity
DWB92_RS08115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DWB92_RS08120	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DWB92_RS08125	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DWB92_RS08130	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DWB92_RS08140	COG1323	Belongs to the UPF0348 family
DWB92_RS08145	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DWB92_RS08150	COG0742	ribosomal rna small subunit methyltransferase
DWB92_RS08165	COG0584	glycerophosphoryl diester phosphodiesterase
DWB92_RS08170	COG3679	Belongs to the UPF0342 family
DWB92_RS08200	COG0772	Belongs to the SEDS family
DWB92_RS08205	COG4838	Belongs to the UPF0358 family
DWB92_RS08210	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DWB92_RS08215	COG4896	Protein conserved in bacteria
DWB92_RS08220	COG1902	pentaerythritol trinitrate reductase activity
DWB92_RS08225	COG1217	gtp-binding protein TYPA
DWB92_RS08235	COG0483	inositol monophosphate 1-phosphatase activity
DWB92_RS08240	COG4493	Belongs to the UPF0637 family
DWB92_RS08260	COG1177	transmembrane transport
DWB92_RS08270	COG3842	ATPase activity
DWB92_RS08280	COG4476	Belongs to the UPF0223 family
DWB92_RS08290	COG0508	dehydrogenase complex catalyzes the overall conversion of
DWB92_RS08310	COG0242	peptide deformylase activity
DWB92_RS08320	COG5503	Protein of unknown function (DUF1447)
DWB92_RS08325	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DWB92_RS08330	COG0569	domain protein
DWB92_RS08335	COG1294	oxidase, subunit
DWB92_RS08375	COG4721	ABC-type cobalt transport system, permease component
DWB92_RS08395	COG0138	bifunctional purine biosynthesis protein purh
DWB92_RS08405	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DWB92_RS08415	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DWB92_RS08425	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DWB92_RS08430	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DWB92_RS08440	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DWB92_RS08445	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DWB92_RS08450	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DWB92_RS08450	COG1017	nitric oxide dioxygenase activity
DWB92_RS08470	COG1845	cytochrome c oxidase, subunit III
DWB92_RS08475	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DWB92_RS08500	COG1682	transport, permease protein
DWB92_RS08520	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DWB92_RS08535	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DWB92_RS08560	COG3594	Acyltransferase
DWB92_RS08565	COG0436	Aminotransferase
DWB92_RS08570	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DWB92_RS08575	COG0596	Alpha beta hydrolase
DWB92_RS08585	COG1169	isochorismate synthase
DWB92_RS08595	COG0390	transport system, permease component
DWB92_RS08600	COG4619	ABC transporter
DWB92_RS08605	COG0456	acetyltransferase
DWB92_RS08650	COG0739	heme binding
DWB92_RS08735	COG0756	dUTP diphosphatase activity
DWB92_RS08775	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DWB92_RS08800	COG0629	single-stranded DNA binding
DWB92_RS08845	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DWB92_RS08865	COG0582	viral genome integration into host DNA
DWB92_RS08945	COG4873	Protein conserved in bacteria
DWB92_RS08955	COG0737	Belongs to the 5'-nucleotidase family
DWB92_RS08960	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DWB92_RS08965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DWB92_RS08970	COG0861	Integral membrane protein TerC family
DWB92_RS08985	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DWB92_RS08990	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DWB92_RS09000	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DWB92_RS09005	COG2382	esterase
DWB92_RS09015	COG0628	permease
DWB92_RS09025	COG0569	domain protein
DWB92_RS09025	COG0475	glutathione-regulated potassium exporter activity
DWB92_RS09030	COG2239	Acts as a magnesium transporter
DWB92_RS09035	COG0564	pseudouridine synthase activity
DWB92_RS09040	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DWB92_RS09045	COG2357	RelA SpoT domain protein
DWB92_RS09060	COG2346	COG2346, Truncated hemoglobins
DWB92_RS09065	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DWB92_RS09070	COG1164	Oligoendopeptidase f
DWB92_RS09085	COG1393	Belongs to the ArsC family
DWB92_RS09110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DWB92_RS09115	COG0601	transmembrane transport
DWB92_RS09140	COG0542	response to heat
DWB92_RS09145	COG2151	metal-sulfur cluster biosynthetic enzyme
DWB92_RS09150	COG0561	phosphatase activity
DWB92_RS09155	COG0446	pyridine nucleotide-disulphide oxidoreductase
DWB92_RS09165	COG0179	Fumarylacetoacetate (FAA) hydrolase
DWB92_RS09175	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
DWB92_RS09185	COG0681	Belongs to the peptidase S26 family
DWB92_RS09190	COG0166	Belongs to the GPI family
DWB92_RS09195	COG0137	argininosuccinate synthase activity
DWB92_RS09200	COG0165	Argininosuccinate lyase
DWB92_RS09205	COG0584	glycerophosphoryl diester phosphodiesterase
DWB92_RS09220	COG1012	belongs to the aldehyde dehydrogenase family
DWB92_RS09225	COG1098	S1 RNA binding domain
DWB92_RS09245	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DWB92_RS09255	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DWB92_RS09255	COG2111	Na H antiporter
DWB92_RS09265	COG1006	Multisubunit Na H antiporter MnhC subunit
DWB92_RS09270	COG0651	ATP synthesis coupled electron transport
DWB92_RS09275	COG1863	multisubunit Na H antiporter MnhE subunit
DWB92_RS09280	COG2212	antiporter activity
DWB92_RS09285	COG1320	monovalent cation:proton antiporter activity
DWB92_RS09290	COG2050	protein possibly involved in aromatic compounds catabolism
DWB92_RS09300	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DWB92_RS09305	COG1252	NADH dehydrogenase
DWB92_RS09310	COG0316	Belongs to the HesB IscA family
DWB92_RS09315	COG4844	belongs to the
DWB92_RS09320	COG1252	NADH dehydrogenase
DWB92_RS09325	COG4837	Protein of unknown function (DUF1462)
DWB92_RS09330	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DWB92_RS09335	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
DWB92_RS09345	COG1696	Membrane protein involved in D-alanine export
DWB92_RS09370	COG0366	Alpha amylase catalytic
DWB92_RS09405	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DWB92_RS09415	COG2445	Protein of unknown function DUF86
DWB92_RS09425	COG0706	membrane insertase activity
DWB92_RS09430	COG4470	Protein conserved in bacteria
DWB92_RS09440	COG0737	Belongs to the 5'-nucleotidase family
DWB92_RS09445	COG0730	response to heat
DWB92_RS09450	COG1801	Protein of unknown function DUF72
DWB92_RS09465	COG1253	flavin adenine dinucleotide binding
DWB92_RS09490	COG1302	Protein conserved in bacteria
DWB92_RS09495	COG5632	N-Acetylmuramoyl-L-alanine amidase
DWB92_RS09495	COG1388	LysM domain
DWB92_RS09600	COG1783	phage Terminase large subunit
DWB92_RS09620	COG0756	dUTP diphosphatase activity
DWB92_RS09680	COG0305	Participates in initiation and elongation during chromosome replication
DWB92_RS09755	COG0719	Fe-S assembly protein
DWB92_RS09760	COG0822	iron-sulfur transferase activity
DWB92_RS09770	COG0719	Fe-S assembly protein
DWB92_RS09775	COG0396	ATPase activity
DWB92_RS09785	COG1464	Belongs to the NlpA lipoprotein family
DWB92_RS09790	COG2011	ABC-type metal ion transport system permease component
DWB92_RS09795	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DWB92_RS09800	COG0492	ferredoxin-NADP+ reductase activity
DWB92_RS09800	COG3118	belongs to the thioredoxin family
DWB92_RS09830	COG0710	3-dehydroquinate dehydratase activity
DWB92_RS09835	COG1764	response to oxidative stress
DWB92_RS09850	COG0477	Major facilitator Superfamily
DWB92_RS09855	COG2217	Heavy metal translocating P-type atpase
DWB92_RS09870	COG3237	CsbD-like
DWB92_RS09900	COG0557	exoribonuclease II activity
DWB92_RS09905	COG1647	Serine aminopeptidase, S33
DWB92_RS09910	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DWB92_RS09920	COG0148	phosphopyruvate hydratase activity
DWB92_RS09925	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DWB92_RS09930	COG0149	triose-phosphate isomerase activity
DWB92_RS09935	COG0126	phosphoglycerate kinase activity
DWB92_RS09965	COG1090	epimerase
DWB92_RS09990	COG1278	Cold shock
DWB92_RS10005	COG0740	serine-type endopeptidase activity
DWB92_RS10010	COG1481	regulation of sporulation
DWB92_RS10015	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DWB92_RS10020	COG1660	Displays ATPase and GTPase activities
DWB92_RS10025	COG0492	ferredoxin-NADP+ reductase activity
DWB92_RS10035	COG0110	maltose O-acetyltransferase activity
DWB92_RS10045	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DWB92_RS10085	COG0653	protein targeting
DWB92_RS10090	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DWB92_RS10100	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
DWB92_RS10120	COG2199	diguanylate cyclase activity
DWB92_RS10135	COG2195	Cleaves the N-terminal amino acid of tripeptides
DWB92_RS10140	COG1929	Belongs to the glycerate kinase type-1 family
DWB92_RS10165	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DWB92_RS10175	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DWB92_RS10185	COG1780	Probably involved in ribonucleotide reductase function
DWB92_RS10195	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DWB92_RS10200	COG3104	oligopeptide transport
DWB92_RS10225	COG1174	glycine betaine transport
DWB92_RS10230	COG0517	IMP dehydrogenase activity
DWB92_RS10230	COG1125	glycine betaine transport
DWB92_RS10235	COG0514	ATP-dependent DNA helicase (RecQ)
DWB92_RS10240	COG0488	(ABC) transporter
DWB92_RS10250	COG1368	sulfuric ester hydrolase activity
DWB92_RS10270	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DWB92_RS10270	COG0512	Glutamine amidotransferase of anthranilate synthase
DWB92_RS10275	COG0512	Glutamine amidotransferase of anthranilate synthase
DWB92_RS10275	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DWB92_RS10285	COG0720	synthase
DWB92_RS10290	COG0602	queuosine metabolic process
DWB92_RS10310	COG1253	flavin adenine dinucleotide binding
DWB92_RS10315	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DWB92_RS10315	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DWB92_RS10315	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DWB92_RS10320	COG1105	Belongs to the carbohydrate kinase PfkB family
DWB92_RS10325	COG1349	DNA-binding transcription factor activity
DWB92_RS10330	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DWB92_RS10335	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DWB92_RS10355	COG1266	CAAX protease self-immunity
DWB92_RS10360	COG0039	L-malate dehydrogenase activity
DWB92_RS10370	COG4989	oxidoreductase activity
DWB92_RS10375	COG0523	cobalamin synthesis protein
DWB92_RS10390	COG4988	ABC transporter
DWB92_RS10395	COG1968	undecaprenyl-diphosphatase activity
DWB92_RS10415	COG1671	Belongs to the UPF0178 family
DWB92_RS10420	COG1611	Belongs to the LOG family
DWB92_RS10450	COG2839	Protein conserved in bacteria
DWB92_RS10455	COG2814	Major facilitator Superfamily
DWB92_RS10460	COG0583	DNA-binding transcription factor activity
DWB92_RS10470	COG0217	transcriptional regulatory protein
DWB92_RS10480	COG2022	thiamine diphosphate biosynthetic process
DWB92_RS10490	COG0352	thiamine-phosphate diphosphorylase activity
DWB92_RS10500	COG3942	CHAP domain
DWB92_RS10500	COG1388	LysM domain
DWB92_RS10505	COG0306	phosphate transporter
DWB92_RS10510	COG1392	Phosphate transport regulator
DWB92_RS10530	COG3949	Membrane
DWB92_RS10535	COG0477	Major facilitator Superfamily
DWB92_RS10545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWB92_RS10550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWB92_RS10555	COG1120	ATPase activity
DWB92_RS10560	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DWB92_RS10565	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DWB92_RS10590	COG1686	Belongs to the peptidase S11 family
DWB92_RS10605	COG1682	transport, permease protein
DWB92_RS10615	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
DWB92_RS10640	COG1121	(ABC) transporter
DWB92_RS10645	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DWB92_RS10650	COG0803	Belongs to the bacterial solute-binding protein 9 family
DWB92_RS10655	COG1320	monovalent cation:proton antiporter activity
DWB92_RS10660	COG2212	antiporter activity
DWB92_RS10665	COG1863	multisubunit Na H antiporter MnhE subunit
DWB92_RS10670	COG0651	ATP synthesis coupled electron transport
DWB92_RS10675	COG1006	Multisubunit Na H antiporter MnhC subunit
DWB92_RS10680	COG2111	Na H antiporter
DWB92_RS10685	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DWB92_RS10685	COG2111	Na H antiporter
DWB92_RS10690	COG0582	viral genome integration into host DNA
DWB92_RS10725	COG0596	Alpha beta hydrolase
DWB92_RS10750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWB92_RS10755	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DWB92_RS10775	COG1078	dGTPase activity
DWB92_RS10785	COG0655	NAD(P)H dehydrogenase (quinone) activity
DWB92_RS10790	COG4844	belongs to the
DWB92_RS10795	COG0471	metal ion transport
DWB92_RS10810	COG0531	amino acid
DWB92_RS10820	COG0280	phosphate acetyltransferase
DWB92_RS10825	COG0095	Lipoate-protein ligase
DWB92_RS10830	COG2814	Major facilitator Superfamily
DWB92_RS10835	COG1566	PFAM secretion protein HlyD family protein
DWB92_RS10850	COG0531	amino acid
DWB92_RS10855	COG2363	Small membrane protein
DWB92_RS10865	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DWB92_RS10885	COG0183	Belongs to the thiolase family
DWB92_RS10890	COG0318	PFAM AMP-dependent synthetase and ligase
DWB92_RS10900	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
DWB92_RS10905	COG0363	glucosamine-6-phosphate deaminase activity
DWB92_RS10915	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DWB92_RS10940	COG1428	Deoxynucleoside kinase
DWB92_RS10945	COG1428	Deoxynucleoside kinase
DWB92_RS10955	COG1609	Transcriptional regulator
DWB92_RS10960	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DWB92_RS10965	COG0561	phosphatase activity
DWB92_RS10975	COG0738	Major facilitator superfamily
DWB92_RS10985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DWB92_RS10995	COG1473	amidohydrolase
DWB92_RS11000	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DWB92_RS11005	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DWB92_RS11010	COG0049	tRNA binding
DWB92_RS11015	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DWB92_RS11025	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DWB92_RS11035	COG2813	Specifically methylates the guanine in position
DWB92_RS11045	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DWB92_RS11050	COG0081	regulation of translation
DWB92_RS11055	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DWB92_RS11065	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DWB92_RS11070	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DWB92_RS11085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DWB92_RS11090	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
DWB92_RS11095	COG0215	cysteine-tRNA ligase activity
DWB92_RS11120	COG4956	integral membrane protein (PIN domain superfamily)
DWB92_RS11125	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DWB92_RS11130	COG0542	response to heat
DWB92_RS11135	COG3869	Catalyzes the specific phosphorylation of arginine residues in
DWB92_RS11140	COG3880	PFAM UvrB UvrC protein
DWB92_RS11150	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DWB92_RS11160	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DWB92_RS11165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DWB92_RS11255	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DWB92_RS11260	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DWB92_RS11265	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DWB92_RS11285	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DWB92_RS11290	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DWB92_RS11305	COG1098	S1 RNA binding domain
DWB92_RS11315	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DWB92_RS11320	COG3956	TIGRFAM MazG family protein
DWB92_RS11325	COG2244	polysaccharide biosynthetic process
DWB92_RS11330	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DWB92_RS11335	COG0193	aminoacyl-tRNA hydrolase activity
DWB92_RS11345	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DWB92_RS11350	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DWB92_RS11355	COG2088	sporulation resulting in formation of a cellular spore
DWB92_RS11360	COG0251	oxidation-reduction process
DWB92_RS11365	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DWB92_RS11370	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DWB92_RS11375	COG4466	Protein conserved in bacteria
DWB92_RS11380	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DWB92_RS11390	COG0084	hydrolase, TatD family'
DWB92_RS11400	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DWB92_RS11405	COG2827	Endonuclease containing a URI domain
DWB92_RS11410	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DWB92_RS11420	COG1774	PSP1 C-terminal conserved region
DWB92_RS11425	COG0470	DNA polymerase III
DWB92_RS11430	COG3870	Protein conserved in bacteria
DWB92_RS11435	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DWB92_RS11440	COG1982	Orn Lys Arg decarboxylase major
DWB92_RS11465	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DWB92_RS11470	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DWB92_RS11490	COG2188	Transcriptional regulator
DWB92_RS11495	COG0366	Alpha amylase catalytic
DWB92_RS11500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DWB92_RS11500	COG1263	PTS System
DWB92_RS11510	COG0493	'glutamate synthase
DWB92_RS11515	COG0069	glutamate synthase activity
DWB92_RS11515	COG0070	glutamate synthase
DWB92_RS11515	COG0067	glutamate synthase
DWB92_RS11550	COG1309	transcriptional regulator
DWB92_RS11565	COG0626	cystathionine gamma-synthase activity
DWB92_RS11570	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DWB92_RS11580	COG2272	Belongs to the type-B carboxylesterase lipase family
DWB92_RS11585	COG0733	neurotransmitter:sodium symporter activity
DWB92_RS11590	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DWB92_RS11595	COG0574	Belongs to the PEP-utilizing enzyme family
DWB92_RS11595	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DWB92_RS11605	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DWB92_RS11610	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DWB92_RS11620	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DWB92_RS11635	COG2076	Multidrug Resistance protein
DWB92_RS11640	COG2076	Multidrug Resistance protein
DWB92_RS11650	COG1124	(ABC) transporter
DWB92_RS11655	COG0444	Belongs to the ABC transporter superfamily
DWB92_RS11660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DWB92_RS11665	COG0601	transmembrane transport
DWB92_RS11670	COG0747	negative chemotaxis
DWB92_RS11695	COG1011	Hydrolase
DWB92_RS11710	COG1846	Transcriptional regulator
DWB92_RS11715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DWB92_RS11730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DWB92_RS11735	COG1609	Transcriptional regulator
DWB92_RS11745	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DWB92_RS11745	COG0519	Catalyzes the synthesis of GMP from XMP
DWB92_RS11750	COG0517	IMP dehydrogenase activity
DWB92_RS11750	COG0516	GMP reductase activity
DWB92_RS11755	COG2233	PERMEase
DWB92_RS11760	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DWB92_RS11780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DWB92_RS11785	COG1823	symporter activity
DWB92_RS11790	COG0778	Nitroreductase
DWB92_RS11800	COG0450	alkyl hydroperoxide reductase
DWB92_RS11820	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DWB92_RS11830	COG3850	Histidine kinase
DWB92_RS11830	COG5002	protein histidine kinase activity
DWB92_RS11845	COG1929	Belongs to the glycerate kinase type-1 family
DWB92_RS11870	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DWB92_RS11880	COG0360	Binds together with S18 to 16S ribosomal RNA
DWB92_RS11885	COG2910	NAD(P)H-binding
DWB92_RS11895	COG4481	Protein conserved in bacteria
DWB92_RS11900	COG0668	transmembrane transport
DWB92_RS11905	COG1475	DNA binding
DWB92_RS11910	COG0626	cystathionine gamma-synthase activity
DWB92_RS11915	COG0626	cystathionine gamma-synthase activity
DWB92_RS11920	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DWB92_RS11920	COG0646	methionine synthase
DWB92_RS11935	COG1279	arginine transmembrane transporter activity
DWB92_RS11940	COG0829	nickel cation binding
DWB92_RS11950	COG0830	nickel cation binding
DWB92_RS11955	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
DWB92_RS11960	COG1966	Carbon starvation protein
DWB92_RS11965	COG2353	YceI-like domain
DWB92_RS11980	COG2388	GCN5-related N-acetyl-transferase
DWB92_RS11995	COG1846	Transcriptional regulator
DWB92_RS12000	COG0346	lactoylglutathione lyase activity
DWB92_RS12005	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DWB92_RS12010	COG0400	carboxylic ester hydrolase activity
DWB92_RS12015	COG1475	DNA binding
DWB92_RS12020	COG0357	Ribosomal RNA small subunit methyltransferase G
DWB92_RS12025	COG0445	tRNA wobble uridine modification
DWB92_RS12030	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DWB92_RS12035	COG0594	ribonuclease P activity