locus-tag	class	description
CEQ12_RS00010	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CEQ12_RS00065	COG3321	synthase
CEQ12_RS00065	COG0604	alcohol dehydrogenase
CEQ12_RS00065	COG1028	Short-chain dehydrogenase reductase Sdr
CEQ12_RS00070	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CEQ12_RS00075	COG0693	protein deglycase activity
CEQ12_RS00080	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CEQ12_RS00080	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CEQ12_RS00085	COG1063	alcohol dehydrogenase
CEQ12_RS00095	COG1733	regulation of RNA biosynthetic process
CEQ12_RS00100	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CEQ12_RS00140	COG1733	regulation of RNA biosynthetic process
CEQ12_RS00150	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CEQ12_RS00160	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CEQ12_RS00165	COG3395	kinase activity
CEQ12_RS00170	COG1349	DNA-binding transcription factor activity
CEQ12_RS00235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CEQ12_RS00250	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CEQ12_RS00255	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CEQ12_RS00260	COG1388	LysM domain
CEQ12_RS00270	COG0604	alcohol dehydrogenase
CEQ12_RS00330	COG2610	gluconate transmembrane transporter activity
CEQ12_RS00335	COG2610	gluconate transmembrane transporter activity
CEQ12_RS00360	COG1063	alcohol dehydrogenase
CEQ12_RS00400	COG0589	response to stress
CEQ12_RS00405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CEQ12_RS00410	COG2079	MmgE PrpD family protein
CEQ12_RS00415	COG1126	abc transporter atp-binding protein
CEQ12_RS00420	COG0765	amino acid transport
CEQ12_RS00425	COG0456	acetyltransferase
CEQ12_RS00430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CEQ12_RS00440	COG1192	Involved in chromosome partitioning
CEQ12_RS00470	COG0753	catalase activity
CEQ12_RS00485	COG1607	acyl-coa hydrolase
CEQ12_RS00505	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CEQ12_RS00510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CEQ12_RS00515	COG0861	Integral membrane protein TerC family
CEQ12_RS00520	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CEQ12_RS00530	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CEQ12_RS00535	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CEQ12_RS00540	COG2814	Major facilitator Superfamily
CEQ12_RS00545	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CEQ12_RS00550	COG2382	esterase
CEQ12_RS00555	COG1115	amino acid carrier protein
CEQ12_RS00560	COG0628	permease
CEQ12_RS00575	COG2239	Acts as a magnesium transporter
CEQ12_RS00580	COG0564	pseudouridine synthase activity
CEQ12_RS00585	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CEQ12_RS00590	COG2357	RelA SpoT domain protein
CEQ12_RS00600	COG4116	CYTH
CEQ12_RS00605	COG2346	COG2346, Truncated hemoglobins
CEQ12_RS00610	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CEQ12_RS00615	COG1164	Oligoendopeptidase f
CEQ12_RS00625	COG4862	establishment of competence for transformation
CEQ12_RS00630	COG1393	Belongs to the ArsC family
CEQ12_RS00635	COG0180	Tryptophanyl-tRNA synthetase
CEQ12_RS00640	COG4166	transmembrane transport
CEQ12_RS00645	COG4608	Belongs to the ABC transporter superfamily
CEQ12_RS00650	COG0444	Belongs to the ABC transporter superfamily
CEQ12_RS00655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEQ12_RS00660	COG0601	transmembrane transport
CEQ12_RS00680	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CEQ12_RS00710	COG0561	phosphatase activity
CEQ12_RS00715	COG0446	pyridine nucleotide-disulphide oxidoreductase
CEQ12_RS00725	COG0179	Fumarylacetoacetate (FAA) hydrolase
CEQ12_RS00730	COG2311	Membrane
CEQ12_RS00735	COG1074	ATP-dependent DNA helicase activity
CEQ12_RS00740	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CEQ12_RS00755	COG0398	Pfam SNARE associated Golgi protein
CEQ12_RS00760	COG0166	Belongs to the GPI family
CEQ12_RS00765	COG0137	argininosuccinate synthase activity
CEQ12_RS00770	COG0165	Argininosuccinate lyase
CEQ12_RS00780	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CEQ12_RS00790	COG0584	glycerophosphoryl diester phosphodiesterase
CEQ12_RS00800	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CEQ12_RS00805	COG1902	pentaerythritol trinitrate reductase activity
CEQ12_RS00810	COG1098	S1 RNA binding domain
CEQ12_RS00815	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CEQ12_RS00825	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CEQ12_RS00825	COG2111	Na H antiporter
CEQ12_RS00830	COG2111	Na H antiporter
CEQ12_RS00835	COG1006	Multisubunit Na H antiporter MnhC subunit
CEQ12_RS00840	COG0651	ATP synthesis coupled electron transport
CEQ12_RS00845	COG1863	multisubunit Na H antiporter MnhE subunit
CEQ12_RS00850	COG2212	antiporter activity
CEQ12_RS00855	COG1320	monovalent cation:proton antiporter activity
CEQ12_RS00865	COG2050	protein possibly involved in aromatic compounds catabolism
CEQ12_RS00870	COG2056	Na+-H+ antiporter family
CEQ12_RS00875	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CEQ12_RS00880	COG1252	NADH dehydrogenase
CEQ12_RS00885	COG0316	Belongs to the HesB IscA family
CEQ12_RS00890	COG4844	belongs to the
CEQ12_RS00895	COG1252	NADH dehydrogenase
CEQ12_RS00900	COG4837	Protein of unknown function (DUF1462)
CEQ12_RS00905	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CEQ12_RS00910	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CEQ12_RS00915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CEQ12_RS00920	COG1696	Membrane protein involved in D-alanine export
CEQ12_RS00925	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CEQ12_RS00940	COG0647	UMP catabolic process
CEQ12_RS00945	COG2445	Protein of unknown function DUF86
CEQ12_RS00955	COG4470	Protein conserved in bacteria
CEQ12_RS00960	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CEQ12_RS00965	COG0737	Belongs to the 5'-nucleotidase family
CEQ12_RS00970	COG0730	response to heat
CEQ12_RS00975	COG1801	Protein of unknown function DUF72
CEQ12_RS00980	COG2070	2-Nitropropane dioxygenase
CEQ12_RS00985	COG1253	flavin adenine dinucleotide binding
CEQ12_RS00990	COG0719	Fe-S assembly protein
CEQ12_RS00995	COG0822	iron-sulfur transferase activity
CEQ12_RS01005	COG0719	Fe-S assembly protein
CEQ12_RS01010	COG0396	ATPase activity
CEQ12_RS01020	COG1464	Belongs to the NlpA lipoprotein family
CEQ12_RS01025	COG2011	ABC-type metal ion transport system permease component
CEQ12_RS01030	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CEQ12_RS01035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CEQ12_RS01040	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CEQ12_RS01045	COG0509	glycine decarboxylation via glycine cleavage system
CEQ12_RS01050	COG1393	Belongs to the ArsC family
CEQ12_RS01055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CEQ12_RS01060	COG0778	Nitroreductase
CEQ12_RS01065	COG0710	3-dehydroquinate dehydratase activity
CEQ12_RS01070	COG1764	response to oxidative stress
CEQ12_RS01085	COG2851	Citrate transporter
CEQ12_RS01100	COG2314	TM2 domain
CEQ12_RS01135	COG0346	lactoylglutathione lyase activity
CEQ12_RS01160	COG1288	antiporter activity
CEQ12_RS01245	COG2329	Antibiotic biosynthesis monooxygenase
CEQ12_RS01295	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CEQ12_RS01300	COG0557	exoribonuclease II activity
CEQ12_RS01305	COG1647	Serine aminopeptidase, S33
CEQ12_RS01310	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CEQ12_RS01320	COG0148	phosphopyruvate hydratase activity
CEQ12_RS01325	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CEQ12_RS01330	COG0149	triose-phosphate isomerase activity
CEQ12_RS01335	COG0126	phosphoglycerate kinase activity
CEQ12_RS01340	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CEQ12_RS01365	COG1090	epimerase
CEQ12_RS01375	COG0740	serine-type endopeptidase activity
CEQ12_RS01510	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CEQ12_RS01515	COG1481	regulation of sporulation
CEQ12_RS01520	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CEQ12_RS01525	COG1660	Displays ATPase and GTPase activities
CEQ12_RS01530	COG0492	ferredoxin-NADP+ reductase activity
CEQ12_RS01540	COG0110	maltose O-acetyltransferase activity
CEQ12_RS01545	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CEQ12_RS01550	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CEQ12_RS01555	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CEQ12_RS01560	COG0556	nucleotide-excision repair
CEQ12_RS01575	COG1388	LysM domain
CEQ12_RS01575	COG3942	CHAP domain
CEQ12_RS01585	COG0653	protein targeting
CEQ12_RS01590	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CEQ12_RS01595	COG1040	competence protein
CEQ12_RS01600	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CEQ12_RS01610	COG1739	Uncharacterized protein family UPF0029
CEQ12_RS01615	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CEQ12_RS01620	COG2199	diguanylate cyclase activity
CEQ12_RS01635	COG2195	Cleaves the N-terminal amino acid of tripeptides
CEQ12_RS01640	COG1929	Belongs to the glycerate kinase type-1 family
CEQ12_RS01660	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CEQ12_RS01675	COG4607	ABC-type enterochelin transport system periplasmic component
CEQ12_RS01680	COG4604	ABC transporter, ATP-binding protein
CEQ12_RS01685	COG4605	iron ion homeostasis
CEQ12_RS01690	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CEQ12_RS01695	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CEQ12_RS01700	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CEQ12_RS01705	COG1780	Probably involved in ribonucleotide reductase function
CEQ12_RS01720	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CEQ12_RS01725	COG3104	oligopeptide transport
CEQ12_RS01730	COG3104	oligopeptide transport
CEQ12_RS01735	COG1597	lipid kinase activity
CEQ12_RS01745	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CEQ12_RS01750	COG1174	glycine betaine transport
CEQ12_RS01755	COG0517	IMP dehydrogenase activity
CEQ12_RS01755	COG1125	glycine betaine transport
CEQ12_RS01760	COG0514	ATP-dependent DNA helicase (RecQ)
CEQ12_RS01765	COG0488	(ABC) transporter
CEQ12_RS01775	COG1368	sulfuric ester hydrolase activity
CEQ12_RS01785	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CEQ12_RS01805	COG0512	Glutamine amidotransferase of anthranilate synthase
CEQ12_RS01805	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CEQ12_RS01810	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CEQ12_RS01815	COG0720	synthase
CEQ12_RS01820	COG0602	queuosine metabolic process
CEQ12_RS01835	COG0463	Glycosyl transferase, family 2
CEQ12_RS01840	COG0656	L-ascorbic acid biosynthetic process
CEQ12_RS01845	COG1253	flavin adenine dinucleotide binding
CEQ12_RS01850	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CEQ12_RS01855	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CEQ12_RS01855	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CEQ12_RS01855	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CEQ12_RS01860	COG1105	Belongs to the carbohydrate kinase PfkB family
CEQ12_RS01865	COG1349	DNA-binding transcription factor activity
CEQ12_RS01875	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CEQ12_RS01880	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CEQ12_RS01915	COG0586	Pfam SNARE associated Golgi protein
CEQ12_RS01925	COG4989	oxidoreductase activity
CEQ12_RS01940	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CEQ12_RS01945	COG4988	ABC transporter
CEQ12_RS01950	COG1968	undecaprenyl-diphosphatase activity
CEQ12_RS01960	COG1671	Belongs to the UPF0178 family
CEQ12_RS01965	COG1611	Belongs to the LOG family
CEQ12_RS01970	COG1279	arginine transmembrane transporter activity
CEQ12_RS01975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CEQ12_RS01980	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CEQ12_RS02005	COG2814	Major facilitator Superfamily
CEQ12_RS02010	COG2839	Protein conserved in bacteria
CEQ12_RS02020	COG0583	DNA-binding transcription factor activity
CEQ12_RS02030	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CEQ12_RS02040	COG0217	transcriptional regulatory protein
CEQ12_RS02060	COG1388	LysM domain
CEQ12_RS02060	COG3942	CHAP domain
CEQ12_RS02065	COG0306	phosphate transporter
CEQ12_RS02070	COG1392	Phosphate transport regulator
CEQ12_RS02075	COG2205	protein histidine kinase activity
CEQ12_RS02080	COG0745	RESPONSE REGULATOR receiver
CEQ12_RS02085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CEQ12_RS02095	COG0657	acetylesterase activity
CEQ12_RS02100	COG3949	Membrane
CEQ12_RS02110	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CEQ12_RS02120	COG2376	Dihydroxyacetone kinase
CEQ12_RS02125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CEQ12_RS02130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CEQ12_RS02135	COG1120	ATPase activity
CEQ12_RS02140	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CEQ12_RS02145	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CEQ12_RS02150	COG1132	(ABC) transporter
CEQ12_RS02155	COG1686	Belongs to the peptidase S11 family
CEQ12_RS02160	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CEQ12_RS02170	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CEQ12_RS02175	COG1682	transport, permease protein
CEQ12_RS02180	COG1134	teichoic acid transport
CEQ12_RS02185	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CEQ12_RS02200	COG1321	iron dependent repressor
CEQ12_RS02205	COG1121	(ABC) transporter
CEQ12_RS02210	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CEQ12_RS02215	COG0803	Belongs to the bacterial solute-binding protein 9 family
CEQ12_RS02225	COG1320	monovalent cation:proton antiporter activity
CEQ12_RS02230	COG2212	antiporter activity
CEQ12_RS02235	COG1863	multisubunit Na H antiporter MnhE subunit
CEQ12_RS02240	COG0651	ATP synthesis coupled electron transport
CEQ12_RS02245	COG1006	Multisubunit Na H antiporter MnhC subunit
CEQ12_RS02250	COG2111	Na H antiporter
CEQ12_RS02255	COG2111	Na H antiporter
CEQ12_RS02255	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CEQ12_RS02295	COG0596	Alpha beta hydrolase
CEQ12_RS02320	COG4139	cobalamin transport
CEQ12_RS02325	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CEQ12_RS02330	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CEQ12_RS02335	COG0018	arginyl-trna synthetase
CEQ12_RS02350	COG1078	dGTPase activity
CEQ12_RS02355	COG0456	acetyltransferase
CEQ12_RS02360	COG0655	NAD(P)H dehydrogenase (quinone) activity
CEQ12_RS02365	COG0667	Aldo Keto reductase
CEQ12_RS02385	COG1028	Short-chain dehydrogenase reductase Sdr
CEQ12_RS02390	COG4844	belongs to the
CEQ12_RS02405	COG0083	homoserine kinase activity
CEQ12_RS02410	COG0095	Lipoate-protein ligase
CEQ12_RS02415	COG0280	phosphate acetyltransferase
CEQ12_RS02420	COG3253	May function as heme-dependent peroxidase
CEQ12_RS02440	COG2363	Small membrane protein
CEQ12_RS02450	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CEQ12_RS02485	COG0183	Belongs to the thiolase family
CEQ12_RS02490	COG0318	PFAM AMP-dependent synthetase and ligase
CEQ12_RS02500	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CEQ12_RS02505	COG0363	glucosamine-6-phosphate deaminase activity
CEQ12_RS02515	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CEQ12_RS02520	COG1469	GTP cyclohydrolase I activity
CEQ12_RS02535	COG0431	NADPH-dependent FMN reductase
CEQ12_RS02540	COG0561	phosphatase activity
CEQ12_RS02550	COG1428	Deoxynucleoside kinase
CEQ12_RS02555	COG1428	Deoxynucleoside kinase
CEQ12_RS02570	COG4297	protein containing double-stranded beta helix domain
CEQ12_RS02575	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CEQ12_RS02580	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CEQ12_RS02590	COG0583	DNA-binding transcription factor activity
CEQ12_RS02595	COG2814	Major facilitator Superfamily
CEQ12_RS02605	COG1113	amino acid transport
CEQ12_RS02615	COG0010	Belongs to the arginase family
CEQ12_RS02625	COG3949	Membrane
CEQ12_RS02635	COG1028	Short-chain dehydrogenase reductase Sdr
CEQ12_RS02640	COG1312	Catalyzes the dehydration of D-mannonate
CEQ12_RS02645	COG1904	glucuronate isomerase
CEQ12_RS02665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CEQ12_RS02680	COG0583	DNA-binding transcription factor activity
CEQ12_RS02710	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CEQ12_RS02710	COG0463	Glycosyl transferase, family 2
CEQ12_RS02730	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CEQ12_RS02735	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CEQ12_RS02770	COG1473	amidohydrolase
CEQ12_RS02775	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CEQ12_RS02780	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CEQ12_RS02785	COG0049	tRNA binding
CEQ12_RS02790	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CEQ12_RS02800	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CEQ12_RS02805	COG0085	RNA polymerase activity
CEQ12_RS02810	COG2813	Specifically methylates the guanine in position
CEQ12_RS02815	COG0222	ribosome binding
CEQ12_RS02820	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CEQ12_RS02825	COG0081	regulation of translation
CEQ12_RS02830	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CEQ12_RS02835	COG0250	Participates in transcription elongation, termination and antitermination
CEQ12_RS02840	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CEQ12_RS02845	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CEQ12_RS02860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CEQ12_RS02865	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CEQ12_RS02870	COG0215	cysteine-tRNA ligase activity
CEQ12_RS02875	COG1045	serine acetyltransferase
CEQ12_RS02880	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CEQ12_RS02885	COG4956	integral membrane protein (PIN domain superfamily)
CEQ12_RS02890	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CEQ12_RS02895	COG0542	response to heat
CEQ12_RS02900	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CEQ12_RS02905	COG3880	PFAM UvrB UvrC protein
CEQ12_RS02910	COG4463	regulation of RNA biosynthetic process
CEQ12_RS02915	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CEQ12_RS02920	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CEQ12_RS02925	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CEQ12_RS02930	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CEQ12_RS03015	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CEQ12_RS03020	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CEQ12_RS03040	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CEQ12_RS03045	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CEQ12_RS03055	COG0037	tRNA processing
CEQ12_RS03060	COG1098	S1 RNA binding domain
CEQ12_RS03070	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CEQ12_RS03075	COG3956	TIGRFAM MazG family protein
CEQ12_RS03080	COG2244	polysaccharide biosynthetic process
CEQ12_RS03085	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CEQ12_RS03090	COG0193	aminoacyl-tRNA hydrolase activity
CEQ12_RS03095	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CEQ12_RS03100	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CEQ12_RS03105	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CEQ12_RS03110	COG2088	sporulation resulting in formation of a cellular spore
CEQ12_RS03115	COG0251	oxidation-reduction process
CEQ12_RS03120	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CEQ12_RS03125	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CEQ12_RS03130	COG4466	Protein conserved in bacteria
CEQ12_RS03135	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CEQ12_RS03140	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CEQ12_RS03145	COG0084	hydrolase, TatD family'
CEQ12_RS03150	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CEQ12_RS03150	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CEQ12_RS03155	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CEQ12_RS03160	COG2827	Endonuclease containing a URI domain
CEQ12_RS03165	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CEQ12_RS03170	COG4467	Involved in initiation control of chromosome replication
CEQ12_RS03175	COG1774	PSP1 C-terminal conserved region
CEQ12_RS03180	COG0470	DNA polymerase III
CEQ12_RS03185	COG3870	Protein conserved in bacteria
CEQ12_RS03190	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CEQ12_RS03195	COG1982	Orn Lys Arg decarboxylase major
CEQ12_RS03215	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CEQ12_RS03220	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CEQ12_RS03225	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CEQ12_RS03230	COG3153	acetyltransferase
CEQ12_RS03240	COG2188	Transcriptional regulator
CEQ12_RS03245	COG0366	Alpha amylase catalytic
CEQ12_RS03250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CEQ12_RS03250	COG1263	PTS System
CEQ12_RS03260	COG0493	'glutamate synthase
CEQ12_RS03265	COG0070	glutamate synthase
CEQ12_RS03265	COG0069	glutamate synthase activity
CEQ12_RS03265	COG0067	glutamate synthase
CEQ12_RS03270	COG0583	DNA-binding transcription factor activity
CEQ12_RS03295	COG1051	belongs to the nudix hydrolase family
CEQ12_RS03305	COG1388	LysM domain
CEQ12_RS03305	COG3942	CHAP domain
CEQ12_RS03315	COG0129	dihydroxy-acid dehydratase activity
CEQ12_RS03330	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CEQ12_RS03335	COG0733	neurotransmitter:sodium symporter activity
CEQ12_RS03340	COG1114	Component of the transport system for branched-chain amino acids
CEQ12_RS03345	COG5646	InterPro IPR014922
CEQ12_RS03350	COG1647	Serine aminopeptidase, S33
CEQ12_RS03355	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CEQ12_RS03360	COG2807	transmembrane transport
CEQ12_RS03365	COG0549	Belongs to the carbamate kinase family
CEQ12_RS03375	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CEQ12_RS03380	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CEQ12_RS03385	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CEQ12_RS03395	COG3257	ureidoglycine aminohydrolase activity
CEQ12_RS03400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CEQ12_RS03410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CEQ12_RS03415	COG0406	alpha-ribazole phosphatase activity
CEQ12_RS03420	COG1115	amino acid carrier protein
CEQ12_RS03425	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CEQ12_RS03430	COG1953	Uracil, thiamine, allantoin
CEQ12_RS03435	COG2508	Transcriptional regulator
CEQ12_RS03440	COG2814	Major facilitator Superfamily
CEQ12_RS03490	COG1764	response to oxidative stress
CEQ12_RS03565	COG0659	secondary active sulfate transmembrane transporter activity
CEQ12_RS03570	COG0589	response to stress
CEQ12_RS03585	COG0519	Catalyzes the synthesis of GMP from XMP
CEQ12_RS03585	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CEQ12_RS03590	COG0517	IMP dehydrogenase activity
CEQ12_RS03590	COG0516	GMP reductase activity
CEQ12_RS03595	COG2233	PERMEase
CEQ12_RS03600	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CEQ12_RS03620	COG1823	symporter activity
CEQ12_RS03630	COG1760	l-serine dehydratase
CEQ12_RS03635	COG1760	l-serine dehydratase
CEQ12_RS03650	COG0778	Nitroreductase
CEQ12_RS03655	COG0753	catalase activity
CEQ12_RS03660	COG3620	sequence-specific DNA binding
CEQ12_RS03665	COG0450	alkyl hydroperoxide reductase
CEQ12_RS03670	COG3634	alkyl hydroperoxide reductase activity
CEQ12_RS03695	COG1280	lysine exporter protein (LysE YggA)
CEQ12_RS03700	COG2076	Multidrug Resistance protein
CEQ12_RS03705	COG2076	Multidrug Resistance protein
CEQ12_RS03715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CEQ12_RS03730	COG4195	phage-related replication protein
CEQ12_RS03735	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CEQ12_RS03750	COG3266	domain, Protein
CEQ12_RS03750	COG4193	domain, Protein
CEQ12_RS03750	COG5632	N-Acetylmuramoyl-L-alanine amidase
CEQ12_RS03765	COG1476	TRANSCRIPTIONal
CEQ12_RS03865	COG2176	DNA-directed DNA polymerase activity
CEQ12_RS03875	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CEQ12_RS03885	COG0360	Binds together with S18 to 16S ribosomal RNA
CEQ12_RS03895	COG0012	GTP binding
CEQ12_RS03900	COG4481	Protein conserved in bacteria
CEQ12_RS03905	COG0668	transmembrane transport
CEQ12_RS03910	COG5609	conserved protein (DUF2294)
CEQ12_RS03915	COG3002	Belongs to the UPF0753 family
CEQ12_RS03920	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CEQ12_RS03930	COG1131	(ABC) transporter
CEQ12_RS03935	COG1136	(ABC) transporter
CEQ12_RS03935	COG0577	efflux transmembrane transporter activity
CEQ12_RS03940	COG1136	(ABC) transporter
CEQ12_RS03955	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CEQ12_RS03965	COG2814	Major facilitator Superfamily
CEQ12_RS03990	COG0772	Belongs to the SEDS family
CEQ12_RS04020	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CEQ12_RS04030	COG0529	Catalyzes the synthesis of activated sulfate
CEQ12_RS04035	COG2046	Belongs to the sulfate adenylyltransferase family
CEQ12_RS04040	COG0730	response to heat
CEQ12_RS04055	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CEQ12_RS04060	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CEQ12_RS04065	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CEQ12_RS04070	COG0175	sulfate reduction
CEQ12_RS04090	COG1017	nitric oxide dioxygenase activity
CEQ12_RS04090	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CEQ12_RS04095	COG1475	DNA binding
CEQ12_RS04105	COG0626	cystathionine gamma-synthase activity
CEQ12_RS04110	COG0626	cystathionine gamma-synthase activity
CEQ12_RS04115	COG0646	methionine synthase
CEQ12_RS04115	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CEQ12_RS04120	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CEQ12_RS04130	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CEQ12_RS04150	COG0183	Belongs to the thiolase family
CEQ12_RS04155	COG1024	Enoyl-CoA hydratase
CEQ12_RS04155	COG1250	3-hydroxyacyl-CoA dehydrogenase
CEQ12_RS04160	COG1960	acyl-CoA dehydrogenase activity
CEQ12_RS04165	COG0318	PFAM AMP-dependent synthetase and ligase
CEQ12_RS04175	COG0789	Transcriptional regulator
CEQ12_RS04200	COG0384	phenazine biosynthesis protein PhzF
CEQ12_RS04210	COG0561	phosphatase activity
CEQ12_RS04220	COG0697	spore germination
CEQ12_RS04230	COG0531	amino acid
CEQ12_RS04235	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CEQ12_RS04265	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CEQ12_RS04275	COG2271	Major facilitator Superfamily
CEQ12_RS04285	COG1966	Carbon starvation protein
CEQ12_RS04290	COG1475	DNA binding
CEQ12_RS04295	COG0357	Ribosomal RNA small subunit methyltransferase G
CEQ12_RS04300	COG0445	tRNA wobble uridine modification
CEQ12_RS04305	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CEQ12_RS04310	COG0594	ribonuclease P activity
CEQ12_RS04320	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CEQ12_RS04325	COG0592	DNA-directed DNA polymerase activity
CEQ12_RS04330	COG2501	S4 domain
CEQ12_RS04335	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CEQ12_RS04340	COG0187	DNA topoisomerase II activity
CEQ12_RS04345	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CEQ12_RS04350	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CEQ12_RS04355	COG2986	histidine ammonia-lyase
CEQ12_RS04360	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CEQ12_RS04365	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CEQ12_RS04375	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CEQ12_RS04385	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CEQ12_RS04390	COG0359	binds to the 23S rRNA
CEQ12_RS04395	COG0305	Participates in initiation and elongation during chromosome replication
CEQ12_RS04400	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CEQ12_RS04405	COG1819	glycosyl
CEQ12_RS04420	COG0745	RESPONSE REGULATOR receiver
CEQ12_RS04425	COG5002	protein histidine kinase activity
CEQ12_RS04440	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CEQ12_RS04445	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CEQ12_RS04460	COG1705	Flagellar rod assembly protein muramidase FlgJ
CEQ12_RS04460	COG3942	CHAP domain
CEQ12_RS04475	COG4195	phage-related replication protein
CEQ12_RS04480	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
CEQ12_RS04500	COG0668	transmembrane transport
CEQ12_RS04520	COG1737	Transcriptional regulator
CEQ12_RS04525	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CEQ12_RS04535	COG1447	Phosphotransferase system cellobiose-specific component IIA
CEQ12_RS04560	COG0640	Transcriptional regulator
CEQ12_RS04580	COG0446	pyridine nucleotide-disulphide oxidoreductase
CEQ12_RS04590	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CEQ12_RS04595	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CEQ12_RS04640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CEQ12_RS04645	COG2210	Belongs to the sulfur carrier protein TusA family
CEQ12_RS04650	COG1937	Protein conserved in bacteria
CEQ12_RS04655	COG0730	response to heat
CEQ12_RS04680	COG1388	LysM domain
CEQ12_RS04690	COG0604	alcohol dehydrogenase
CEQ12_RS04715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CEQ12_RS04720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CEQ12_RS04780	COG1695	Transcriptional regulator
CEQ12_RS04800	COG1063	alcohol dehydrogenase
CEQ12_RS04805	COG0693	protein deglycase activity
CEQ12_RS04820	COG0583	DNA-binding transcription factor activity
CEQ12_RS04825	COG1607	acyl-coa hydrolase
CEQ12_RS04835	COG1063	alcohol dehydrogenase
CEQ12_RS04860	COG1309	transcriptional regulator
CEQ12_RS04875	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CEQ12_RS04890	COG0471	metal ion transport
CEQ12_RS04905	COG3711	transcriptional antiterminator
CEQ12_RS04910	COG1263	PTS System
CEQ12_RS04910	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CEQ12_RS04910	COG2190	(PTS) system
CEQ12_RS04915	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CEQ12_RS04920	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CEQ12_RS04930	COG1876	peptidase activity
CEQ12_RS04935	COG1686	Belongs to the peptidase S11 family
CEQ12_RS04940	COG0402	S-adenosylhomocysteine deaminase activity
CEQ12_RS04960	COG1511	domain protein
CEQ12_RS04965	COG2207	Transcriptional regulator
CEQ12_RS04970	COG2211	Major facilitator Superfamily
CEQ12_RS04975	COG3250	beta-galactosidase activity
CEQ12_RS04985	COG3655	Transcriptional regulator
CEQ12_RS05000	COG0579	oxidoreductase
CEQ12_RS05005	COG1028	Short-chain dehydrogenase reductase Sdr
CEQ12_RS05010	COG0471	metal ion transport
CEQ12_RS05015	COG2318	DinB family
CEQ12_RS05020	COG1388	LysM domain
CEQ12_RS05025	COG0564	pseudouridine synthase activity
CEQ12_RS05030	COG1388	LysM domain
CEQ12_RS05035	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CEQ12_RS05045	COG1054	Belongs to the UPF0176 family
CEQ12_RS05060	COG1511	domain protein
CEQ12_RS05060	COG1511	domain protein
CEQ12_RS05075	COG1917	Cupin 2, conserved barrel domain protein
CEQ12_RS05075	COG2207	Transcriptional regulator
CEQ12_RS05085	COG1070	Carbohydrate kinase
CEQ12_RS05100	COG2022	thiamine diphosphate biosynthetic process
CEQ12_RS05105	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CEQ12_RS05110	COG1328	CTP reductase activity
CEQ12_RS05120	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
CEQ12_RS05125	COG4932	domain protein
CEQ12_RS05125	COG3583	domain protein
CEQ12_RS05125	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CEQ12_RS05135	COG0431	NADPH-dependent FMN reductase
CEQ12_RS05145	COG0346	lactoylglutathione lyase activity
CEQ12_RS05160	COG4932	domain protein
CEQ12_RS05160	COG3583	domain protein
CEQ12_RS05160	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CEQ12_RS05170	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CEQ12_RS05195	COG0477	Major facilitator Superfamily
CEQ12_RS05205	COG2814	Major facilitator Superfamily
CEQ12_RS05225	COG0584	glycerophosphoryl diester phosphodiesterase
CEQ12_RS05240	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CEQ12_RS05245	COG1846	Transcriptional regulator
CEQ12_RS05250	COG3961	Belongs to the TPP enzyme family
CEQ12_RS05265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CEQ12_RS05290	COG0673	inositol 2-dehydrogenase activity
CEQ12_RS05300	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CEQ12_RS05305	COG1691	(AIR) carboxylase
CEQ12_RS05310	COG1606	tRNA processing
CEQ12_RS05315	COG3875	lactate racemase activity
CEQ12_RS05330	COG3835	regulator
CEQ12_RS05335	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CEQ12_RS05335	COG0574	Belongs to the PEP-utilizing enzyme family
CEQ12_RS05340	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CEQ12_RS05365	COG1476	TRANSCRIPTIONal
CEQ12_RS05370	COG2807	transmembrane transport
CEQ12_RS05380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CEQ12_RS05390	COG1012	belongs to the aldehyde dehydrogenase family
CEQ12_RS05425	COG1510	regulation of RNA biosynthetic process
CEQ12_RS05430	COG1012	belongs to the aldehyde dehydrogenase family
CEQ12_RS05435	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CEQ12_RS05440	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CEQ12_RS05440	COG0463	Glycosyl transferase, family 2
CEQ12_RS05445	COG0778	Nitroreductase
CEQ12_RS05450	COG2843	Capsule synthesis protein
CEQ12_RS05455	COG1957	nucleoside hydrolase
CEQ12_RS05460	COG0477	Major facilitator Superfamily
CEQ12_RS05485	COG2610	gluconate transmembrane transporter activity
CEQ12_RS05490	COG1349	DNA-binding transcription factor activity
CEQ12_RS05520	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CEQ12_RS05525	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CEQ12_RS05530	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CEQ12_RS05535	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CEQ12_RS05540	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CEQ12_RS05545	COG0431	NADPH-dependent FMN reductase
CEQ12_RS05555	COG1620	l-lactate permease
CEQ12_RS05560	COG2814	Major facilitator Superfamily
CEQ12_RS05570	COG2190	(PTS) system
CEQ12_RS05570	COG1263	PTS System
CEQ12_RS05570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CEQ12_RS05575	COG0363	glucosamine-6-phosphate deaminase activity
CEQ12_RS05585	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CEQ12_RS05620	COG3711	transcriptional antiterminator
CEQ12_RS05625	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CEQ12_RS05635	COG3037	sugar-specific permease SgaT UlaA
CEQ12_RS05645	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CEQ12_RS05660	COG0640	Transcriptional regulator
CEQ12_RS05670	COG1464	Belongs to the NlpA lipoprotein family
CEQ12_RS05675	COG0039	L-malate dehydrogenase activity
CEQ12_RS05680	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CEQ12_RS05680	COG3711	transcriptional antiterminator
CEQ12_RS05685	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CEQ12_RS05685	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CEQ12_RS05685	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CEQ12_RS05690	COG1482	cell wall glycoprotein biosynthetic process
CEQ12_RS05735	COG1309	transcriptional regulator
CEQ12_RS05745	COG3949	Membrane
CEQ12_RS05760	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CEQ12_RS05765	COG0830	nickel cation binding
CEQ12_RS05770	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CEQ12_RS05775	COG0804	urea catabolic process
CEQ12_RS05780	COG0832	Belongs to the urease beta subunit family
CEQ12_RS05785	COG0831	urea catabolic process
CEQ12_RS05790	COG4413	Urea transporter
CEQ12_RS05795	COG0747	negative chemotaxis
CEQ12_RS05820	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CEQ12_RS05835	COG0561	phosphatase activity
CEQ12_RS05845	COG0167	dihydroorotate dehydrogenase activity
CEQ12_RS05850	COG3001	Fructosamine kinase
CEQ12_RS05860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CEQ12_RS05875	COG0697	spore germination
CEQ12_RS05895	COG3189	MarR family transcriptional regulator
CEQ12_RS05910	COG1388	LysM domain
CEQ12_RS05915	COG0436	Aminotransferase
CEQ12_RS05925	COG2608	mercury ion transmembrane transporter activity
CEQ12_RS05930	COG2217	Heavy metal translocating P-type atpase
CEQ12_RS05935	COG0659	secondary active sulfate transmembrane transporter activity
CEQ12_RS05940	COG1136	(ABC) transporter
CEQ12_RS05945	COG0577	efflux transmembrane transporter activity
CEQ12_RS05950	COG1028	Short-chain dehydrogenase reductase Sdr
CEQ12_RS05960	COG0471	metal ion transport
CEQ12_RS05965	COG5505	Protein of unknown function (DUF819)
CEQ12_RS05980	COG4336	lyase activity
CEQ12_RS05995	COG1012	belongs to the aldehyde dehydrogenase family
CEQ12_RS06005	COG2409	Drug exporters of the RND superfamily
CEQ12_RS06020	COG1473	amidohydrolase
CEQ12_RS06040	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CEQ12_RS06045	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CEQ12_RS06050	COG3425	synthase
CEQ12_RS06065	COG3386	PFAM SMP-30 Gluconolaconase
CEQ12_RS06070	COG1757	Na H antiporter
CEQ12_RS06075	COG0583	DNA-binding transcription factor activity
CEQ12_RS06090	COG0028	Belongs to the TPP enzyme family
CEQ12_RS06095	COG1288	antiporter activity
CEQ12_RS06110	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CEQ12_RS06125	COG0657	acetylesterase activity
CEQ12_RS06140	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CEQ12_RS06160	COG3949	Membrane
CEQ12_RS06180	COG1129	ABC transporter
CEQ12_RS06190	COG1609	Transcriptional regulator
CEQ12_RS06200	COG1070	Carbohydrate kinase
CEQ12_RS06205	COG1063	alcohol dehydrogenase
CEQ12_RS06225	COG3764	Sortase (surface protein transpeptidase)
CEQ12_RS06230	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
CEQ12_RS06235	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CEQ12_RS06245	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CEQ12_RS06250	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CEQ12_RS06255	COG0561	phosphatase activity
CEQ12_RS06260	COG0778	Nitroreductase
CEQ12_RS06265	COG2514	catechol 2,3-dioxygenase activity
CEQ12_RS06270	COG1132	(ABC) transporter
CEQ12_RS06275	COG1132	(ABC) transporter
CEQ12_RS06285	COG0803	Belongs to the bacterial solute-binding protein 9 family
CEQ12_RS06290	COG1012	belongs to the aldehyde dehydrogenase family
CEQ12_RS06295	COG1846	Transcriptional regulator
CEQ12_RS06300	COG0346	lactoylglutathione lyase activity
CEQ12_RS06305	COG0346	lactoylglutathione lyase activity
CEQ12_RS06310	COG0400	carboxylic ester hydrolase activity
CEQ12_RS06315	COG3949	Membrane
CEQ12_RS06320	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
CEQ12_RS06325	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CEQ12_RS06330	COG0586	Pfam SNARE associated Golgi protein
CEQ12_RS06335	COG2271	Major facilitator Superfamily
CEQ12_RS06345	COG3527	Alpha-acetolactate decarboxylase
CEQ12_RS06365	COG4876	unkown
CEQ12_RS06370	COG2357	RelA SpoT domain protein
CEQ12_RS06380	COG1802	Transcriptional regulator
CEQ12_RS06385	COG1070	Carbohydrate kinase
CEQ12_RS06390	COG2610	gluconate transmembrane transporter activity
CEQ12_RS06395	COG3949	Membrane
CEQ12_RS06400	COG2207	Transcriptional regulator
CEQ12_RS06405	COG2211	Major facilitator Superfamily
CEQ12_RS06440	COG4221	oxidoreductase activity
CEQ12_RS06455	COG0107	imidazoleglycerol-phosphate synthase activity
CEQ12_RS06460	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CEQ12_RS06465	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CEQ12_RS06470	COG0131	Imidazoleglycerol-phosphate dehydratase
CEQ12_RS06480	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CEQ12_RS06485	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CEQ12_RS06495	COG3048	D-serine ammonia-lyase activity
CEQ12_RS06500	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CEQ12_RS06510	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CEQ12_RS06515	COG1028	Short-chain dehydrogenase reductase Sdr
CEQ12_RS06520	COG1363	Peptidase, m42
CEQ12_RS06530	COG0069	glutamate synthase activity
CEQ12_RS06540	COG4619	ABC transporter
CEQ12_RS06545	COG0390	transport system, permease component
CEQ12_RS06550	COG2814	Major facilitator Superfamily
CEQ12_RS06555	COG2851	Citrate transporter
CEQ12_RS06560	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
CEQ12_RS06570	COG3246	L-lysine catabolic process to acetate
CEQ12_RS06575	COG1250	3-hydroxyacyl-CoA dehydrogenase
CEQ12_RS06590	COG1174	glycine betaine transport
CEQ12_RS06600	COG1174	glycine betaine transport
CEQ12_RS06615	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CEQ12_RS06625	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CEQ12_RS06625	COG1116	anion transmembrane transporter activity
CEQ12_RS06635	COG1346	cytolysis
CEQ12_RS06645	COG3279	Response regulator of the LytR AlgR family
CEQ12_RS06650	COG3275	phosphorelay sensor kinase activity
CEQ12_RS06660	COG4187	Peptidase family M20/M25/M40
CEQ12_RS06680	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CEQ12_RS06690	COG0706	membrane insertase activity
CEQ12_RS06695	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CEQ12_RS06710	COG2814	Major facilitator Superfamily
CEQ12_RS06720	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CEQ12_RS06725	COG1388	LysM domain
CEQ12_RS06730	COG0588	phosphoglycerate mutase activity
CEQ12_RS06740	COG2814	Major facilitator Superfamily
CEQ12_RS06755	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CEQ12_RS06760	COG0803	Belongs to the bacterial solute-binding protein 9 family
CEQ12_RS06760	COG3443	Belongs to the bacterial solute-binding protein 9 family
CEQ12_RS06780	COG2116	formate transmembrane transporter activity
CEQ12_RS06785	COG0454	-acetyltransferase
CEQ12_RS06805	COG1846	Transcriptional regulator
CEQ12_RS06840	COG1283	sodium-dependent phosphate transmembrane transporter activity
CEQ12_RS06845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CEQ12_RS06850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CEQ12_RS06855	COG1288	antiporter activity
CEQ12_RS06860	COG1349	DNA-binding transcription factor activity
CEQ12_RS06865	COG1063	alcohol dehydrogenase
CEQ12_RS06870	COG2376	Dihydroxyacetone kinase
CEQ12_RS06880	COG0698	ribose 5-phosphate isomerase
CEQ12_RS06900	COG0492	ferredoxin-NADP+ reductase activity
CEQ12_RS06910	COG2814	Major facilitator Superfamily
CEQ12_RS06915	COG0604	alcohol dehydrogenase
CEQ12_RS06930	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CEQ12_RS06935	COG1620	l-lactate permease
CEQ12_RS06940	COG0438	transferase activity, transferring glycosyl groups
CEQ12_RS06950	COG3850	Histidine kinase
CEQ12_RS06950	COG5002	protein histidine kinase activity
CEQ12_RS06955	COG0745	RESPONSE REGULATOR receiver
CEQ12_RS06960	COG0577	efflux transmembrane transporter activity
CEQ12_RS06965	COG1136	(ABC) transporter
CEQ12_RS06980	COG4640	response to antibiotic
CEQ12_RS06985	COG2814	Major facilitator Superfamily
CEQ12_RS06995	COG1566	PFAM secretion protein HlyD family protein
CEQ12_RS07000	COG2814	Major facilitator Superfamily
CEQ12_RS07025	COG0598	Magnesium transport protein CorA
CEQ12_RS07030	COG1304	FMN binding
CEQ12_RS07035	COG0786	glutamate:sodium symporter activity
CEQ12_RS07040	COG1695	Transcriptional regulator
CEQ12_RS07055	COG1757	Na H antiporter
CEQ12_RS07060	COG2094	Belongs to the DNA glycosylase MPG family
CEQ12_RS07075	COG4152	abc transporter atp-binding protein
CEQ12_RS07080	COG1668	transmembrane transport
CEQ12_RS07085	COG2017	converts alpha-aldose to the beta-anomer
CEQ12_RS07090	COG2258	MOSC domain
CEQ12_RS07095	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CEQ12_RS07100	COG1266	CAAX protease self-immunity
CEQ12_RS07105	COG0010	Belongs to the arginase family
CEQ12_RS07110	COG0583	DNA-binding transcription factor activity
CEQ12_RS07115	COG3314	Sporulation integral membrane protein YlbJ
CEQ12_RS07120	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CEQ12_RS07125	COG1228	amidohydrolase
CEQ12_RS07130	COG0659	secondary active sulfate transmembrane transporter activity
CEQ12_RS07135	COG1473	amidohydrolase
CEQ12_RS07140	COG1028	Short-chain dehydrogenase reductase Sdr
CEQ12_RS07145	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CEQ12_RS07160	COG1737	Transcriptional regulator
CEQ12_RS07165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CEQ12_RS07165	COG1263	PTS System
CEQ12_RS07175	COG0385	Bile acid
CEQ12_RS07180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CEQ12_RS07205	COG1113	amino acid transport
CEQ12_RS07210	COG1785	Belongs to the alkaline phosphatase family
CEQ12_RS07215	COG1737	Transcriptional regulator
CEQ12_RS07220	COG1263	PTS System
CEQ12_RS07220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CEQ12_RS07225	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CEQ12_RS07255	COG1316	TRANSCRIPTIONal
CEQ12_RS07260	COG3383	formate dehydrogenase (NAD+) activity
CEQ12_RS07275	COG4193	domain, Protein
CEQ12_RS07285	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CEQ12_RS07290	COG2076	Multidrug Resistance protein
CEQ12_RS07295	COG2076	Multidrug Resistance protein
CEQ12_RS07315	COG1757	Na H antiporter
CEQ12_RS07320	COG3942	CHAP domain
CEQ12_RS07345	COG0765	amino acid transport
CEQ12_RS07350	COG0765	amino acid transport
CEQ12_RS07360	COG1126	abc transporter atp-binding protein
CEQ12_RS07365	COG1960	acyl-CoA dehydrogenase activity
CEQ12_RS07370	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CEQ12_RS07375	COG1268	BioY protein
CEQ12_RS07385	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CEQ12_RS07390	COG1609	Transcriptional regulator
CEQ12_RS07395	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CEQ12_RS07400	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CEQ12_RS07405	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
CEQ12_RS07410	COG0725	ABC transporter, periplasmic molybdate-binding protein
CEQ12_RS07415	COG4149	molybdate abc transporter
CEQ12_RS07430	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CEQ12_RS07435	COG0521	Mo-molybdopterin cofactor biosynthetic process
CEQ12_RS07440	COG0315	cyclic pyranopterin monophosphate synthase activity
CEQ12_RS07450	COG1763	Mo-molybdopterin cofactor biosynthetic process
CEQ12_RS07465	COG0746	molybdenum cofactor guanylyltransferase activity
CEQ12_RS07470	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CEQ12_RS07480	COG2814	Major facilitator Superfamily
CEQ12_RS07500	COG2348	transferase activity, transferring amino-acyl groups
CEQ12_RS07505	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CEQ12_RS07520	COG1028	Short-chain dehydrogenase reductase Sdr
CEQ12_RS07525	COG4975	Glucose uptake
CEQ12_RS07535	COG0551	DNA topoisomerase type I activity
CEQ12_RS07535	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CEQ12_RS07540	COG2252	PERMEase
CEQ12_RS07550	COG0051	transcription antitermination factor activity, RNA binding
CEQ12_RS07555	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CEQ12_RS07560	COG0088	Forms part of the polypeptide exit tunnel
CEQ12_RS07565	COG0089	rRNA binding
CEQ12_RS07570	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CEQ12_RS07575	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CEQ12_RS07580	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CEQ12_RS07585	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CEQ12_RS07590	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CEQ12_RS07595	COG0255	Belongs to the universal ribosomal protein uL29 family
CEQ12_RS07600	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CEQ12_RS07605	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CEQ12_RS07610	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CEQ12_RS07615	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CEQ12_RS07620	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CEQ12_RS07625	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CEQ12_RS07630	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CEQ12_RS07635	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CEQ12_RS07640	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CEQ12_RS07645	COG1841	ribosomal large subunit assembly
CEQ12_RS07655	COG0201	protein transport
CEQ12_RS07660	COG0563	adenylate kinase activity
CEQ12_RS07670	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CEQ12_RS07675	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CEQ12_RS07685	COG0202	RNA polymerase activity
CEQ12_RS07690	COG0203	ribosomal protein L17
CEQ12_RS07695	COG1122	ATPase activity
CEQ12_RS07700	COG1122	ATPase activity
CEQ12_RS07710	COG0101	tRNA pseudouridine synthase activity
CEQ12_RS07715	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CEQ12_RS07730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CEQ12_RS07735	COG2130	NADP-dependent
CEQ12_RS07740	COG0604	alcohol dehydrogenase
CEQ12_RS07745	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CEQ12_RS07760	COG1302	Protein conserved in bacteria
CEQ12_RS07765	COG4264	IucA IucC family
CEQ12_RS07770	COG2814	Major facilitator Superfamily
CEQ12_RS07775	COG4264	IucA IucC family
CEQ12_RS07780	COG3457	Alanine racemase
CEQ12_RS07785	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CEQ12_RS07790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CEQ12_RS07795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CEQ12_RS07800	COG3314	Sporulation integral membrane protein YlbJ
CEQ12_RS07805	COG2329	Antibiotic biosynthesis monooxygenase
CEQ12_RS07815	COG1988	membrane-bound metal-dependent
CEQ12_RS07820	COG4284	Utp--glucose-1-phosphate uridylyltransferase
CEQ12_RS07825	COG1272	protein, Hemolysin III
CEQ12_RS07840	COG2814	Major facilitator Superfamily
CEQ12_RS07845	COG0489	protein tyrosine kinase activity
CEQ12_RS07900	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CEQ12_RS07910	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CEQ12_RS07915	COG0246	Mannitol dehydrogenase
CEQ12_RS07925	COG3711	transcriptional antiterminator
CEQ12_RS07930	COG2213	PTS system mannitol-specific
CEQ12_RS07950	COG1119	ATPase activity
CEQ12_RS07955	COG0561	phosphatase activity
CEQ12_RS07975	COG0640	Transcriptional regulator
CEQ12_RS07980	COG0702	epimerase
CEQ12_RS07985	COG2186	Transcriptional regulator
CEQ12_RS07990	COG1482	cell wall glycoprotein biosynthetic process
CEQ12_RS08000	COG2855	membrane
CEQ12_RS08015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CEQ12_RS08020	COG0783	Belongs to the Dps family
CEQ12_RS08030	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CEQ12_RS08035	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CEQ12_RS08040	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CEQ12_RS08050	COG1854	S-ribosylhomocysteine lyase activity
CEQ12_RS08070	COG5146	pantothenate kinase activity
CEQ12_RS08080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CEQ12_RS08085	COG3343	RNA polymerase activity
CEQ12_RS08090	COG0504	CTP synthase activity
CEQ12_RS08100	COG0191	fructose-bisphosphate aldolase activity
CEQ12_RS08105	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CEQ12_RS08115	COG1012	belongs to the aldehyde dehydrogenase family
CEQ12_RS08120	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CEQ12_RS08125	COG0254	rRNA binding
CEQ12_RS08130	COG1435	thymidine kinase activity
CEQ12_RS08135	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CEQ12_RS08140	COG2890	protein-(glutamine-N5) methyltransferase activity
CEQ12_RS08145	COG0009	L-threonylcarbamoyladenylate synthase
CEQ12_RS08150	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CEQ12_RS08155	COG4475	Protein of unknown function (DUF436)
CEQ12_RS08160	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CEQ12_RS08165	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CEQ12_RS08170	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CEQ12_RS08180	COG0356	it plays a direct role in the translocation of protons across the membrane
CEQ12_RS08185	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CEQ12_RS08190	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CEQ12_RS08195	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CEQ12_RS08200	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CEQ12_RS08205	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CEQ12_RS08210	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CEQ12_RS08215	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CEQ12_RS08225	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CEQ12_RS08230	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CEQ12_RS08240	COG0629	single-stranded DNA binding
CEQ12_RS08245	COG1388	LysM domain
CEQ12_RS08250	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CEQ12_RS08260	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CEQ12_RS08265	COG0352	thiamine-phosphate diphosphorylase activity
CEQ12_RS08270	COG0706	membrane insertase activity
CEQ12_RS08275	COG1418	mRNA catabolic process
CEQ12_RS08285	COG1937	Protein conserved in bacteria
CEQ12_RS08300	COG0772	Belongs to the SEDS family
CEQ12_RS08305	COG1181	Belongs to the D-alanine--D-alanine ligase family
CEQ12_RS08310	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CEQ12_RS08315	COG0513	Belongs to the DEAD box helicase family
CEQ12_RS08325	COG3428	Bacterial PH domain
CEQ12_RS08330	COG3402	PFAM membrane-flanked domain
CEQ12_RS08340	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CEQ12_RS08350	COG2337	Toxic component of a toxin-antitoxin (TA) module
CEQ12_RS08355	COG2208	phosphoserine phosphatase activity
CEQ12_RS08370	COG1191	sigma factor activity
CEQ12_RS08375	COG2183	response to ionizing radiation
CEQ12_RS08380	COG3091	SprT-like family
CEQ12_RS08410	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CEQ12_RS08415	COG0066	3-isopropylmalate dehydratase activity
CEQ12_RS08420	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CEQ12_RS08425	COG0473	3-isopropylmalate dehydrogenase activity
CEQ12_RS08430	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CEQ12_RS08435	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CEQ12_RS08440	COG0440	acetolactate synthase activity
CEQ12_RS08445	COG0028	Belongs to the TPP enzyme family
CEQ12_RS08450	COG0129	dihydroxy-acid dehydratase activity
CEQ12_RS08455	COG0802	atpase or kinase
CEQ12_RS08460	COG1214	PFAM Peptidase M22, glycoprotease
CEQ12_RS08465	COG0456	acetyltransferase
CEQ12_RS08470	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CEQ12_RS08480	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CEQ12_RS08485	COG0488	(ABC) transporter
CEQ12_RS08490	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CEQ12_RS08495	COG2391	methyltransferase activity
CEQ12_RS08500	COG0425	Belongs to the sulfur carrier protein TusA family
CEQ12_RS08505	COG1621	beta-fructofuranosidase activity
CEQ12_RS08510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CEQ12_RS08515	COG3279	Response regulator of the LytR AlgR family
CEQ12_RS08520	COG3290	protein histidine kinase activity
CEQ12_RS08530	COG4512	PFAM Accessory gene regulator B
CEQ12_RS08535	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CEQ12_RS08555	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CEQ12_RS08560	COG0459	protein refolding
CEQ12_RS08580	COG1725	Transcriptional regulator
CEQ12_RS08595	COG1131	(ABC) transporter
CEQ12_RS08635	COG2706	6-phosphogluconolactonase activity
CEQ12_RS08640	COG1012	belongs to the aldehyde dehydrogenase family
CEQ12_RS08645	COG1227	inorganic diphosphatase activity
CEQ12_RS08650	COG1335	isochorismatase
CEQ12_RS08660	COG0471	metal ion transport
CEQ12_RS08665	COG0077	Prephenate dehydratase
CEQ12_RS08675	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CEQ12_RS08680	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CEQ12_RS08685	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
CEQ12_RS08695	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CEQ12_RS08700	COG4496	protein, YerC YecD
CEQ12_RS08710	COG0210	DNA helicase
CEQ12_RS08715	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CEQ12_RS08720	COG4851	CamS sex pheromone cAM373 precursor
CEQ12_RS08725	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CEQ12_RS08730	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CEQ12_RS08735	COG0154	amidase activity
CEQ12_RS08740	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CEQ12_RS08745	COG1597	lipid kinase activity
CEQ12_RS08750	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CEQ12_RS08760	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CEQ12_RS08770	COG1528	Iron-storage protein
CEQ12_RS08785	COG4129	membrane
CEQ12_RS08790	COG0024	Methionine aminopeptidase
CEQ12_RS08805	COG4585	Histidine kinase
CEQ12_RS08810	COG2197	response regulator
CEQ12_RS08815	COG1295	ribonuclease BN
CEQ12_RS08825	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CEQ12_RS08830	COG4840	Belongs to the UPF0435 family
CEQ12_RS08835	COG2309	aminopeptidase activity
CEQ12_RS08840	COG1607	acyl-coa hydrolase
CEQ12_RS08845	COG0535	radical SAM domain protein
CEQ12_RS08855	COG0693	protein deglycase activity
CEQ12_RS08860	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CEQ12_RS08865	COG2137	regulation of response to DNA damage stimulus
CEQ12_RS08875	COG1134	teichoic acid transport
CEQ12_RS08885	COG1988	membrane-bound metal-dependent
CEQ12_RS08890	COG1194	a g-specific adenine glycosylase
CEQ12_RS08895	COG3557	Belongs to the UPF0374 family
CEQ12_RS08905	COG4129	membrane
CEQ12_RS08910	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CEQ12_RS08920	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CEQ12_RS08925	COG0735	belongs to the Fur family
CEQ12_RS09080	COG0765	amino acid transport
CEQ12_RS09085	COG1126	abc transporter atp-binding protein
CEQ12_RS09090	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CEQ12_RS09100	COG0363	glucosamine-6-phosphate deaminase activity
CEQ12_RS09115	COG0114	fumarate hydratase activity
CEQ12_RS09120	COG0564	pseudouridine synthase activity
CEQ12_RS09125	COG2203	Gaf domain
CEQ12_RS09125	COG4585	Histidine kinase
CEQ12_RS09130	COG2197	response regulator
CEQ12_RS09135	COG1301	dicarboxylic acid transport
CEQ12_RS09175	COG0788	formyltetrahydrofolate deformylase activity
CEQ12_RS09185	COG4399	Belongs to the UPF0754 family
CEQ12_RS09190	COG3679	Belongs to the UPF0342 family
CEQ12_RS09195	COG0420	3'-5' exonuclease activity
CEQ12_RS09200	COG4717	serine-type aminopeptidase activity
CEQ12_RS09210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CEQ12_RS09225	COG0537	adenosine 5'-monophosphoramidase activity
CEQ12_RS09230	COG1131	(ABC) transporter
CEQ12_RS09235	COG4473	ABC transporter
CEQ12_RS09245	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CEQ12_RS09250	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CEQ12_RS09255	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CEQ12_RS09315	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CEQ12_RS09325	COG1506	peptidase
CEQ12_RS09330	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CEQ12_RS09335	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CEQ12_RS09345	COG0656	L-ascorbic acid biosynthetic process
CEQ12_RS09350	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CEQ12_RS09355	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CEQ12_RS09365	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CEQ12_RS09390	COG3266	domain, Protein
CEQ12_RS09390	COG4193	domain, Protein
CEQ12_RS09390	COG5632	N-Acetylmuramoyl-L-alanine amidase
CEQ12_RS09405	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CEQ12_RS09405	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CEQ12_RS09410	COG0307	riboflavin synthase, alpha
CEQ12_RS09415	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CEQ12_RS09415	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CEQ12_RS09420	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CEQ12_RS09425	COG0506	proline dehydrogenase activity
CEQ12_RS09430	COG2267	carboxylic ester hydrolase activity
CEQ12_RS09435	COG0039	L-malate dehydrogenase activity
CEQ12_RS09445	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CEQ12_RS09450	COG1242	4 iron, 4 sulfur cluster binding
CEQ12_RS09455	COG2814	Major facilitator Superfamily
CEQ12_RS09460	COG0495	leucyl-tRNA aminoacylation
CEQ12_RS09470	COG2081	HI0933 family
CEQ12_RS09475	COG2244	polysaccharide biosynthetic process
CEQ12_RS09480	COG1187	pseudouridine synthase activity
CEQ12_RS09490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CEQ12_RS09495	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CEQ12_RS09500	COG0510	thiamine kinase activity
CEQ12_RS09505	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CEQ12_RS09510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CEQ12_RS09515	COG5584	Small secreted protein
CEQ12_RS09520	COG1363	Peptidase, m42
CEQ12_RS09525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CEQ12_RS09530	COG4848	Belongs to the UPF0354 family
CEQ12_RS09535	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CEQ12_RS09540	COG1674	ftsk spoiiie
CEQ12_RS09545	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CEQ12_RS09550	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
CEQ12_RS09560	COG1605	Chorismate mutase
CEQ12_RS09560	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CEQ12_RS09565	COG1609	Transcriptional regulator
CEQ12_RS09570	COG0123	including yeast histone deacetylase and acetoin utilization protein
CEQ12_RS09575	COG0454	-acetyltransferase
CEQ12_RS09580	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CEQ12_RS09590	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CEQ12_RS09595	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CEQ12_RS09600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CEQ12_RS09605	COG0204	Acyl-transferase
CEQ12_RS09610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CEQ12_RS09610	COG1263	PTS System
CEQ12_RS09620	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CEQ12_RS09630	COG1764	response to oxidative stress
CEQ12_RS09635	COG0584	glycerophosphoryl diester phosphodiesterase
CEQ12_RS09645	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CEQ12_RS09655	COG1956	GAF domain-containing protein
CEQ12_RS09660	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CEQ12_RS09665	COG1104	cysteine desulfurase activity
CEQ12_RS09670	COG0301	tRNA thio-modification
CEQ12_RS09675	COG0730	response to heat
CEQ12_RS09680	COG0616	signal peptide processing
CEQ12_RS09685	COG1714	RDD family
CEQ12_RS09690	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CEQ12_RS09695	COG0827	DNA restriction-modification system
CEQ12_RS09700	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CEQ12_RS09710	COG0589	response to stress
CEQ12_RS09715	COG0686	Belongs to the AlaDH PNT family
CEQ12_RS09720	COG3142	Participates in the control of copper homeostasis
CEQ12_RS09725	COG0006	proline dipeptidase activity
CEQ12_RS09730	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CEQ12_RS09740	COG4109	DRTGG domain
CEQ12_RS09745	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CEQ12_RS09750	COG0587	DNA-directed DNA polymerase activity
CEQ12_RS09755	COG0281	malic enzyme
CEQ12_RS09760	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CEQ12_RS09765	COG0825	malonyl-CoA metabolic process
CEQ12_RS09770	COG0205	6-phosphofructokinase activity
CEQ12_RS09775	COG0469	pyruvate kinase activity
CEQ12_RS09785	COG0372	Belongs to the citrate synthase family
CEQ12_RS09790	COG0538	isocitrate dehydrogenase activity
CEQ12_RS09795	COG0745	RESPONSE REGULATOR receiver
CEQ12_RS09800	COG5002	protein histidine kinase activity
CEQ12_RS09805	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CEQ12_RS09805	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CEQ12_RS09815	COG0237	dephospho-CoA kinase activity
CEQ12_RS09820	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CEQ12_RS09825	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CEQ12_RS09835	COG1484	DNA-dependent DNA replication
CEQ12_RS09840	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CEQ12_RS09845	COG0833	amino acid
CEQ12_RS09850	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CEQ12_RS09855	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CEQ12_RS09860	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CEQ12_RS09865	COG4112	unkown
CEQ12_RS09875	COG0544	peptidyl-prolyl cis-trans isomerase activity
CEQ12_RS09880	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CEQ12_RS09885	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CEQ12_RS09890	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CEQ12_RS09895	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CEQ12_RS09900	COG0181	hydroxymethylbilane synthase activity
CEQ12_RS09910	COG0113	porphobilinogen synthase activity
CEQ12_RS09915	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CEQ12_RS09925	COG2818	Glycosylase
CEQ12_RS09930	COG0525	valine-tRNA ligase activity
CEQ12_RS09935	COG0285	dihydrofolate synthase activity
CEQ12_RS09945	COG0656	L-ascorbic acid biosynthetic process
CEQ12_RS09955	COG2003	Belongs to the UPF0758 family
CEQ12_RS09980	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CEQ12_RS09985	COG2868	ribosomal protein
CEQ12_RS09995	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CEQ12_RS10000	COG4492	Belongs to the UPF0735 family
CEQ12_RS10005	COG0632	four-way junction helicase activity
CEQ12_RS10010	COG2255	four-way junction helicase activity
CEQ12_RS10015	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CEQ12_RS10020	COG0343	queuine tRNA-ribosyltransferase activity
CEQ12_RS10025	COG1862	Preprotein translocase
CEQ12_RS10030	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CEQ12_RS10030	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CEQ12_RS10035	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CEQ12_RS10035	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CEQ12_RS10040	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CEQ12_RS10045	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CEQ12_RS10050	COG1490	D-aminoacyl-tRNA deacylase activity
CEQ12_RS10055	COG0860	N-Acetylmuramoyl-L-alanine amidase
CEQ12_RS10060	COG0124	histidyl-tRNA synthetase
CEQ12_RS10065	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CEQ12_RS10075	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CEQ12_RS10080	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CEQ12_RS10085	COG1959	2 iron, 2 sulfur cluster binding
CEQ12_RS10095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CEQ12_RS10100	COG0488	(ABC) transporter
CEQ12_RS10105	COG1104	cysteine desulfurase activity
CEQ12_RS10110	COG0482	sulfurtransferase activity
CEQ12_RS10120	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CEQ12_RS10125	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CEQ12_RS10130	COG4472	Bacterial protein of unknown function (DUF965)
CEQ12_RS10135	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CEQ12_RS10140	COG3906	Belongs to the UPF0473 family
CEQ12_RS10145	COG4122	O-methyltransferase activity
CEQ12_RS10150	COG0826	peptidase U32
CEQ12_RS10155	COG0826	peptidase U32
CEQ12_RS10160	COG0572	uridine kinase
CEQ12_RS10165	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CEQ12_RS10170	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CEQ12_RS10175	COG1984	allophanate hydrolase subunit 2
CEQ12_RS10185	COG0439	Biotin carboxylase
CEQ12_RS10190	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CEQ12_RS10195	COG1914	H( )-stimulated, divalent metal cation uptake system
CEQ12_RS10200	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CEQ12_RS10205	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CEQ12_RS10210	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CEQ12_RS10215	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CEQ12_RS10220	COG1534	Rna-binding protein
CEQ12_RS10225	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CEQ12_RS10230	COG1713	HD superfamily hydrolase involved in NAD metabolism
CEQ12_RS10235	COG0799	negative regulation of ribosome biogenesis
CEQ12_RS10250	COG2131	deaminase
CEQ12_RS10255	COG0658	competence protein
CEQ12_RS10255	COG2333	competence protein COMEC
CEQ12_RS10260	COG1466	dna polymerase III delta subunit
CEQ12_RS10265	COG0268	Binds directly to 16S ribosomal RNA
CEQ12_RS10270	COG0481	GTPase activity
CEQ12_RS10275	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CEQ12_RS10280	COG1420	regulation of RNA biosynthetic process
CEQ12_RS10285	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CEQ12_RS10290	COG0443	Heat shock 70 kDa protein
CEQ12_RS10295	COG0484	heat shock protein binding
CEQ12_RS10300	COG2264	protein methyltransferase activity
CEQ12_RS10305	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CEQ12_RS10310	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CEQ12_RS10315	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CEQ12_RS10320	COG1030	water channel activity
CEQ12_RS10325	COG4864	UPF0365 protein
CEQ12_RS10335	COG1702	phosphate starvation-inducible protein PhoH
CEQ12_RS10355	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CEQ12_RS10360	COG1381	Involved in DNA repair and RecF pathway recombination
CEQ12_RS10365	COG0423	glycine-tRNA ligase activity
CEQ12_RS10370	COG0517	IMP dehydrogenase activity
CEQ12_RS10375	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CEQ12_RS10385	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CEQ12_RS10390	COG2384	SAM-dependent methyltransferase
CEQ12_RS10400	COG0513	Belongs to the DEAD box helicase family
CEQ12_RS10405	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CEQ12_RS10410	COG1121	(ABC) transporter
CEQ12_RS10415	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CEQ12_RS10425	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CEQ12_RS10430	COG0768	penicillin binding
CEQ12_RS10435	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CEQ12_RS10440	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CEQ12_RS10445	COG0705	Rhomboid family
CEQ12_RS10445	COG0457	Tetratricopeptide repeat
CEQ12_RS10450	COG4483	Protein conserved in bacteria
CEQ12_RS10455	COG1940	carbohydrate kinase activity
CEQ12_RS10460	COG0011	TIGRFAM Protein of
CEQ12_RS10470	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CEQ12_RS10475	COG1459	type II secretion system
CEQ12_RS10480	COG4537	Required for transformation and DNA binding
CEQ12_RS10505	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CEQ12_RS10510	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CEQ12_RS10515	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CEQ12_RS10520	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CEQ12_RS10525	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CEQ12_RS10530	COG0095	Lipoate-protein ligase
CEQ12_RS10545	COG0006	proline dipeptidase activity
CEQ12_RS10550	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CEQ12_RS10555	COG0511	ligase activity, forming carbon-carbon bonds
CEQ12_RS10560	COG0439	Biotin carboxylase
CEQ12_RS10565	COG1302	Protein conserved in bacteria
CEQ12_RS10570	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CEQ12_RS10575	COG1570	exodeoxyribonuclease VII activity
CEQ12_RS10590	COG1438	arginine binding
CEQ12_RS10595	COG0497	DNA recombination
CEQ12_RS10600	COG0280	phosphate acetyltransferase
CEQ12_RS10605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CEQ12_RS10610	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CEQ12_RS10615	COG0022	dehydrogenase e1 component
CEQ12_RS10620	COG0508	dehydrogenase complex catalyzes the overall conversion of
CEQ12_RS10630	COG4129	membrane
CEQ12_RS10635	COG2195	Cleaves the N-terminal amino acid of tripeptides
CEQ12_RS10645	COG0366	Alpha amylase catalytic
CEQ12_RS10655	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CEQ12_RS10660	COG1234	tRNA 3'-trailer cleavage
CEQ12_RS10665	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CEQ12_RS10670	COG1028	Short-chain dehydrogenase reductase Sdr
CEQ12_RS10675	COG0667	Aldo Keto reductase
CEQ12_RS10685	COG0735	belongs to the Fur family
CEQ12_RS10690	COG4974	Belongs to the 'phage' integrase family
CEQ12_RS10700	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CEQ12_RS10705	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CEQ12_RS10710	COG1187	pseudouridine synthase activity
CEQ12_RS10715	COG0745	RESPONSE REGULATOR receiver
CEQ12_RS10730	COG1141	Ferredoxin
CEQ12_RS10740	COG0514	ATP-dependent DNA helicase (RecQ)
CEQ12_RS10750	COG0492	ferredoxin-NADP+ reductase activity
CEQ12_RS10760	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CEQ12_RS10765	COG0539	negative regulation of cytoplasmic translation
CEQ12_RS10770	COG1160	GTP binding
CEQ12_RS10775	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CEQ12_RS10790	COG2226	methyltransferase
CEQ12_RS10795	COG0142	geranyltranstransferase activity
CEQ12_RS10800	COG0105	UTP biosynthetic process
CEQ12_RS10805	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CEQ12_RS10810	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CEQ12_RS10815	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CEQ12_RS10825	COG5582	Belongs to the UPF0302 family
CEQ12_RS10830	COG4347	Protein of unknown function (DUF1405)
CEQ12_RS10835	COG2738	Putative neutral zinc metallopeptidase
CEQ12_RS10840	COG1694	Mazg nucleotide pyrophosphohydrolase
CEQ12_RS10845	COG0438	transferase activity, transferring glycosyl groups
CEQ12_RS10850	COG0617	tRNA 3'-terminal CCA addition
CEQ12_RS10860	COG1199	ATP-dependent helicase activity
CEQ12_RS10860	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CEQ12_RS10865	COG0017	Asparaginyl-tRNA synthetase
CEQ12_RS10870	COG3935	DnaD domain protein
CEQ12_RS10875	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CEQ12_RS10885	COG4499	WXG100 protein secretion system (Wss), protein YukC
CEQ12_RS10885	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CEQ12_RS10890	COG3331	DNA recombination
CEQ12_RS10900	COG4474	Belongs to the UPF0398 family
CEQ12_RS10915	COG0116	Belongs to the methyltransferase superfamily
CEQ12_RS10920	COG2962	Rard protein
CEQ12_RS10930	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CEQ12_RS10935	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CEQ12_RS10940	COG0328	RNA-DNA hybrid ribonuclease activity
CEQ12_RS10945	COG3545	Serine hydrolase
CEQ12_RS10950	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CEQ12_RS10960	COG1413	lyase activity
CEQ12_RS10965	COG1413	lyase activity
CEQ12_RS10975	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CEQ12_RS10995	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CEQ12_RS11005	COG4479	Belongs to the UPF0346 family
CEQ12_RS11010	COG0793	Belongs to the peptidase S41A family
CEQ12_RS11020	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CEQ12_RS11025	COG0671	phosphoesterase, PA-phosphatase related
CEQ12_RS11030	COG0745	RESPONSE REGULATOR receiver
CEQ12_RS11035	COG5002	protein histidine kinase activity
CEQ12_RS11040	COG0567	Dehydrogenase, E1 component
CEQ12_RS11045	COG0508	dehydrogenase complex catalyzes the overall conversion of
CEQ12_RS11070	COG1396	sequence-specific DNA binding
CEQ12_RS11080	COG2207	Transcriptional regulator
CEQ12_RS11080	COG1917	Cupin 2, conserved barrel domain protein
CEQ12_RS11085	COG1082	Xylose isomerase domain protein TIM barrel
CEQ12_RS11095	COG0673	inositol 2-dehydrogenase activity
CEQ12_RS11100	COG0673	inositol 2-dehydrogenase activity
CEQ12_RS11105	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CEQ12_RS11125	COG0714	Associated with various cellular activities
CEQ12_RS11130	COG4548	von Willebrand factor, type A
CEQ12_RS11135	COG1114	Component of the transport system for branched-chain amino acids
CEQ12_RS11140	COG3853	Toxic anion resistance protein (TelA)
CEQ12_RS11150	COG1254	Belongs to the acylphosphatase family
CEQ12_RS11160	COG1278	Cold shock
CEQ12_RS11175	COG1473	amidohydrolase
CEQ12_RS11185	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CEQ12_RS11190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CEQ12_RS11195	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CEQ12_RS11200	COG0527	aspartate kinase activity
CEQ12_RS11210	COG0488	(ABC) transporter
CEQ12_RS11215	COG2996	Protein conserved in bacteria
CEQ12_RS11220	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CEQ12_RS11225	COG0573	inorganic phosphate transmembrane transporter activity
CEQ12_RS11230	COG0581	inorganic phosphate transmembrane transporter activity
CEQ12_RS11235	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CEQ12_RS11240	COG0704	Plays a role in the regulation of phosphate uptake
CEQ12_RS11255	COG0789	Transcriptional regulator
CEQ12_RS11270	COG2348	transferase activity, transferring amino-acyl groups
CEQ12_RS11275	COG2348	transferase activity, transferring amino-acyl groups
CEQ12_RS11285	COG0159	tryptophan synthase activity
CEQ12_RS11290	COG0133	tryptophan synthase activity
CEQ12_RS11300	COG0134	indole-3-glycerol-phosphate synthase activity
CEQ12_RS11305	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CEQ12_RS11310	COG0512	Glutamine amidotransferase of anthranilate synthase
CEQ12_RS11315	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CEQ12_RS11320	COG0287	Prephenate dehydrogenase
CEQ12_RS11325	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CEQ12_RS11335	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CEQ12_RS11340	COG1942	4-Oxalocrotonate Tautomerase
CEQ12_RS11355	COG1879	ABC-type sugar transport system periplasmic component
CEQ12_RS11360	COG1172	Belongs to the binding-protein-dependent transport system permease family
CEQ12_RS11365	COG1129	ABC transporter
CEQ12_RS11370	COG1869	D-ribose catabolic process
CEQ12_RS11375	COG1609	Transcriptional regulator
CEQ12_RS11385	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CEQ12_RS11385	COG0392	lysyltransferase activity
CEQ12_RS11390	COG0628	permease
CEQ12_RS11395	COG1115	amino acid carrier protein
CEQ12_RS11400	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CEQ12_RS11410	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CEQ12_RS11415	COG4841	protein insertion into membrane
CEQ12_RS11420	COG0824	Thioesterase
CEQ12_RS11430	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CEQ12_RS11435	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CEQ12_RS11440	COG1970	mechanosensitive ion channel activity
CEQ12_RS11445	COG0419	ATPase involved in DNA repair
CEQ12_RS11450	COG0420	3'-5' exonuclease activity
CEQ12_RS11455	COG4846	Membrane protein involved in cytochrome C biogenesis
CEQ12_RS11465	COG3763	UPF0154 protein
CEQ12_RS11485	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CEQ12_RS11495	COG0516	GMP reductase activity
CEQ12_RS11500	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CEQ12_RS11505	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CEQ12_RS11515	COG0753	catalase activity
CEQ12_RS11520	COG0833	amino acid
CEQ12_RS11530	COG0561	phosphatase activity
CEQ12_RS11535	COG0083	homoserine kinase activity
CEQ12_RS11540	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CEQ12_RS11545	COG0460	homoserine dehydrogenase
CEQ12_RS11550	COG0527	aspartate kinase activity
CEQ12_RS11590	COG0174	glutamine synthetase
CEQ12_RS11595	COG0789	Transcriptional regulator
CEQ12_RS11600	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CEQ12_RS11605	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CEQ12_RS11610	COG0386	Belongs to the glutathione peroxidase family
CEQ12_RS11615	COG1923	regulation of RNA biosynthetic process
CEQ12_RS11620	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CEQ12_RS11630	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CEQ12_RS11635	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CEQ12_RS11640	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CEQ12_RS11645	COG1619	proteins homologs of microcin C7 resistance protein MccF
CEQ12_RS11655	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CEQ12_RS11660	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CEQ12_RS11670	COG4550	Control of competence regulator ComK, YlbF/YmcA
CEQ12_RS11675	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CEQ12_RS11685	COG0492	ferredoxin-NADP+ reductase activity
CEQ12_RS11690	COG1959	2 iron, 2 sulfur cluster binding
CEQ12_RS11705	COG1013	pyruvate-flavodoxin oxidoreductase activity
CEQ12_RS11710	COG0674	pyruvate-flavodoxin oxidoreductase activity
CEQ12_RS11710	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CEQ12_RS11715	COG1692	metallophosphoesterase
CEQ12_RS11725	COG1418	mRNA catabolic process
CEQ12_RS11730	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CEQ12_RS11745	COG1426	Protein conserved in bacteria
CEQ12_RS11755	COG0300	oxidoreductase activity
CEQ12_RS11760	COG0612	Peptidase, M16
CEQ12_RS11765	COG0612	Peptidase, M16
CEQ12_RS11780	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CEQ12_RS11785	COG1185	polyribonucleotide nucleotidyltransferase activity
CEQ12_RS11790	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CEQ12_RS11795	COG0196	riboflavin kinase activity
CEQ12_RS11800	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CEQ12_RS11805	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CEQ12_RS11820	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CEQ12_RS11825	COG1358	cellular component organization or biogenesis
CEQ12_RS11830	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CEQ12_RS11835	COG0195	Participates in both transcription termination and antitermination
CEQ12_RS11840	COG0779	Required for maturation of 30S ribosomal subunits
CEQ12_RS11845	COG2176	DNA-directed DNA polymerase activity
CEQ12_RS11850	COG0442	prolyl-tRNA aminoacylation
CEQ12_RS11860	COG4589	Belongs to the CDS family
CEQ12_RS11865	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CEQ12_RS11870	COG0233	cytoplasmic translational termination
CEQ12_RS11875	COG0528	UMP kinase activity
CEQ12_RS11880	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CEQ12_RS11885	COG0052	Belongs to the universal ribosomal protein uS2 family
CEQ12_RS11890	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CEQ12_RS11895	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CEQ12_RS11900	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CEQ12_RS11905	COG4974	Belongs to the 'phage' integrase family
CEQ12_RS11915	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CEQ12_RS11920	COG0758	DNA mediated transformation
CEQ12_RS11930	COG0045	succinate-CoA ligase (ADP-forming) activity
CEQ12_RS11935	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CEQ12_RS11945	COG4485	Bacterial membrane protein, YfhO
CEQ12_RS11955	COG0335	large ribosomal subunit rRNA binding
CEQ12_RS11960	COG0336	Belongs to the RNA methyltransferase TrmD family
CEQ12_RS11965	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CEQ12_RS11970	COG0228	four-way junction DNA binding
CEQ12_RS11975	COG1028	Short-chain dehydrogenase reductase Sdr
CEQ12_RS11980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CEQ12_RS11985	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CEQ12_RS11990	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CEQ12_RS11995	COG0552	protein localization to endoplasmic reticulum
CEQ12_RS12000	COG1196	nuclear chromosome segregation
CEQ12_RS12005	COG0571	ribonuclease III activity
CEQ12_RS12010	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CEQ12_RS12025	COG0416	fatty acid biosynthetic process
CEQ12_RS12030	COG1349	DNA-binding transcription factor activity
CEQ12_RS12040	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CEQ12_RS12045	COG1760	l-serine dehydratase
CEQ12_RS12050	COG1760	l-serine dehydratase
CEQ12_RS12055	COG1461	Dihydroxyacetone kinase
CEQ12_RS12060	COG1302	Protein conserved in bacteria
CEQ12_RS12065	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CEQ12_RS12070	COG1564	THIamine pyrophosphokinase
CEQ12_RS12075	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CEQ12_RS12080	COG1162	GTPase activity
CEQ12_RS12090	COG0631	protein serine/threonine phosphatase activity
CEQ12_RS12095	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CEQ12_RS12100	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CEQ12_RS12100	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CEQ12_RS12105	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CEQ12_RS12125	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CEQ12_RS12130	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CEQ12_RS12135	COG1758	RNA polymerase activity
CEQ12_RS12140	COG0194	GDP metabolic process
CEQ12_RS12145	COG1293	RNA-binding protein homologous to eukaryotic snRNP
CEQ12_RS12155	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CEQ12_RS12160	COG2814	Major facilitator Superfamily
CEQ12_RS12170	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CEQ12_RS12175	COG0284	orotidine-5'-phosphate decarboxylase activity
CEQ12_RS12180	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CEQ12_RS12185	COG0505	Belongs to the CarA family
CEQ12_RS12195	COG0540	Belongs to the ATCase OTCase family
CEQ12_RS12200	COG2233	PERMEase
CEQ12_RS12205	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CEQ12_RS12210	COG0564	pseudouridine synthase activity
CEQ12_RS12215	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CEQ12_RS12225	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CEQ12_RS12230	COG3599	regulation of cell shape
CEQ12_RS12240	COG0762	integral membrane protein
CEQ12_RS12245	COG1799	cell septum assembly
CEQ12_RS12250	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CEQ12_RS12255	COG1496	oxidoreductase activity
CEQ12_RS12260	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CEQ12_RS12265	COG0849	cell division
CEQ12_RS12270	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CEQ12_RS12275	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CEQ12_RS12280	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CEQ12_RS12285	COG0768	penicillin binding
CEQ12_RS12290	COG4839	cell division protein FtsL
CEQ12_RS12295	COG0275	rRNA processing
CEQ12_RS12300	COG2001	Belongs to the MraZ family
CEQ12_RS12305	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
CEQ12_RS12310	COG0454	-acetyltransferase
CEQ12_RS12315	COG1011	Hydrolase
CEQ12_RS12350	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CEQ12_RS12355	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CEQ12_RS12360	COG1053	succinate dehydrogenase
CEQ12_RS12365	COG2009	succinate dehydrogenase
CEQ12_RS12370	COG0322	excinuclease ABC activity
CEQ12_RS12375	COG3118	belongs to the thioredoxin family
CEQ12_RS12380	COG1193	negative regulation of DNA recombination
CEQ12_RS12385	COG1796	DNA polymerase
CEQ12_RS12385	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CEQ12_RS12395	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CEQ12_RS12400	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CEQ12_RS12405	COG0072	phenylalanine-tRNA ligase activity
CEQ12_RS12410	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CEQ12_RS12415	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CEQ12_RS12425	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CEQ12_RS12435	COG1323	Belongs to the UPF0348 family
CEQ12_RS12445	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CEQ12_RS12450	COG0742	ribosomal rna small subunit methyltransferase
CEQ12_RS12470	COG3679	Belongs to the UPF0342 family
CEQ12_RS12480	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CEQ12_RS12490	COG0109	protoheme IX farnesyltransferase activity
CEQ12_RS12495	COG1612	heme a metabolic process
CEQ12_RS12505	COG0772	Belongs to the SEDS family
CEQ12_RS12510	COG4838	Belongs to the UPF0358 family
CEQ12_RS12515	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CEQ12_RS12520	COG4896	Protein conserved in bacteria
CEQ12_RS12525	COG1217	gtp-binding protein TYPA
CEQ12_RS12535	COG0483	inositol monophosphate 1-phosphatase activity
CEQ12_RS12540	COG4493	Belongs to the UPF0637 family
CEQ12_RS12550	COG1914	H( )-stimulated, divalent metal cation uptake system
CEQ12_RS12565	COG1177	transmembrane transport
CEQ12_RS12575	COG3842	ATPase activity
CEQ12_RS12585	COG4476	Belongs to the UPF0223 family
CEQ12_RS12595	COG0508	dehydrogenase complex catalyzes the overall conversion of
CEQ12_RS12615	COG0242	peptide deformylase activity
CEQ12_RS12625	COG5503	Protein of unknown function (DUF1447)
CEQ12_RS12630	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CEQ12_RS12635	COG0569	domain protein
CEQ12_RS12640	COG1294	oxidase, subunit
CEQ12_RS12645	COG1271	oxidase subunit
CEQ12_RS12660	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CEQ12_RS12670	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CEQ12_RS12685	COG4172	Belongs to the ABC transporter superfamily
CEQ12_RS12690	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CEQ12_RS12700	COG0138	bifunctional purine biosynthesis protein purh
CEQ12_RS12710	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CEQ12_RS12720	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CEQ12_RS12725	COG0047	phosphoribosylformylglycinamidine synthase activity
CEQ12_RS12730	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CEQ12_RS12735	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CEQ12_RS12740	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CEQ12_RS12745	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CEQ12_RS12750	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CEQ12_RS12760	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CEQ12_RS12765	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CEQ12_RS12770	COG1845	cytochrome c oxidase, subunit III
CEQ12_RS12775	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CEQ12_RS12790	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CEQ12_RS12795	COG1316	TRANSCRIPTIONal
CEQ12_RS12810	COG3266	domain, Protein
CEQ12_RS12810	COG5632	N-Acetylmuramoyl-L-alanine amidase
CEQ12_RS12810	COG4193	domain, Protein
CEQ12_RS12810	COG3266	domain, Protein
CEQ12_RS12810	COG5632	N-Acetylmuramoyl-L-alanine amidase
CEQ12_RS12810	COG4193	domain, Protein
CEQ12_RS12820	COG3594	Acyltransferase
CEQ12_RS12825	COG0436	Aminotransferase
CEQ12_RS12835	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CEQ12_RS12840	COG2267	carboxylic ester hydrolase activity
CEQ12_RS12845	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CEQ12_RS12850	COG1169	isochorismate synthase
CEQ12_RS12855	COG1575	Belongs to the MenA family. Type 1 subfamily
CEQ12_RS12865	COG2314	TM2 domain
CEQ12_RS12885	COG4903	ComK protein
CEQ12_RS12900	COG4873	Protein conserved in bacteria