locus-tag	class	description
A4G25_RS00030	COG4129	membrane
A4G25_RS00055	COG2197	response regulator
A4G25_RS00060	COG0288	reversible hydration of carbon dioxide
A4G25_RS00065	COG1295	ribonuclease BN
A4G25_RS00080	COG4840	Belongs to the UPF0435 family
A4G25_RS00085	COG2309	aminopeptidase activity
A4G25_RS00090	COG1607	acyl-coa hydrolase
A4G25_RS00100	COG0535	radical SAM domain protein
A4G25_RS00110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A4G25_RS00115	COG2137	regulation of response to DNA damage stimulus
A4G25_RS00125	COG1134	teichoic acid transport
A4G25_RS00125	COG1388	LysM domain
A4G25_RS00135	COG1988	membrane-bound metal-dependent
A4G25_RS00140	COG1194	a g-specific adenine glycosylase
A4G25_RS00145	COG3557	Belongs to the UPF0374 family
A4G25_RS00160	COG4129	membrane
A4G25_RS00165	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A4G25_RS00170	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A4G25_RS00175	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A4G25_RS00180	COG0735	belongs to the Fur family
A4G25_RS00325	COG0765	amino acid transport
A4G25_RS00330	COG1126	abc transporter atp-binding protein
A4G25_RS00335	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A4G25_RS00345	COG0363	glucosamine-6-phosphate deaminase activity
A4G25_RS00355	COG0114	fumarate hydratase activity
A4G25_RS00360	COG0564	pseudouridine synthase activity
A4G25_RS00365	COG2203	Gaf domain
A4G25_RS00365	COG4585	Histidine kinase
A4G25_RS00370	COG2197	response regulator
A4G25_RS00375	COG1301	dicarboxylic acid transport
A4G25_RS00385	COG4399	Belongs to the UPF0754 family
A4G25_RS00390	COG3679	Belongs to the UPF0342 family
A4G25_RS00395	COG0420	3'-5' exonuclease activity
A4G25_RS00405	COG3481	metal-dependent phosphohydrolase, HD sub domain
A4G25_RS00410	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A4G25_RS00425	COG0537	adenosine 5'-monophosphoramidase activity
A4G25_RS00430	COG1131	(ABC) transporter
A4G25_RS00435	COG4473	ABC transporter
A4G25_RS00445	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A4G25_RS00450	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A4G25_RS00455	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
A4G25_RS00465	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A4G25_RS00470	COG0157	Belongs to the NadC ModD family
A4G25_RS00475	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A4G25_RS00480	COG1104	cysteine desulfurase activity
A4G25_RS00485	COG1827	regulation of RNA biosynthetic process
A4G25_RS00490	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A4G25_RS00565	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A4G25_RS00575	COG1506	peptidase
A4G25_RS00580	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A4G25_RS00585	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A4G25_RS00595	COG0656	L-ascorbic acid biosynthetic process
A4G25_RS00605	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A4G25_RS00620	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A4G25_RS00635	COG1595	DNA-templated transcription, initiation
A4G25_RS00645	COG4193	domain, Protein
A4G25_RS00645	COG3266	domain, Protein
A4G25_RS00645	COG5632	N-Acetylmuramoyl-L-alanine amidase
A4G25_RS00655	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A4G25_RS00655	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A4G25_RS00660	COG0307	riboflavin synthase, alpha
A4G25_RS00665	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A4G25_RS00665	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A4G25_RS00670	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A4G25_RS00675	COG0506	proline dehydrogenase activity
A4G25_RS00680	COG2267	carboxylic ester hydrolase activity
A4G25_RS00685	COG0039	L-malate dehydrogenase activity
A4G25_RS00690	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A4G25_RS00695	COG1242	4 iron, 4 sulfur cluster binding
A4G25_RS00700	COG2814	Major facilitator Superfamily
A4G25_RS00715	COG2081	HI0933 family
A4G25_RS00720	COG2244	polysaccharide biosynthetic process
A4G25_RS00725	COG1187	pseudouridine synthase activity
A4G25_RS00735	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4G25_RS00745	COG0510	thiamine kinase activity
A4G25_RS00750	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A4G25_RS00755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4G25_RS00760	COG5584	Small secreted protein
A4G25_RS00765	COG1363	Peptidase, m42
A4G25_RS00770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4G25_RS00775	COG4848	Belongs to the UPF0354 family
A4G25_RS00780	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4G25_RS00785	COG1674	ftsk spoiiie
A4G25_RS00790	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A4G25_RS00795	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
A4G25_RS00805	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A4G25_RS00805	COG1605	Chorismate mutase
A4G25_RS00810	COG1609	Transcriptional regulator
A4G25_RS00820	COG0454	-acetyltransferase
A4G25_RS00825	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A4G25_RS00830	COG2759	Belongs to the formate--tetrahydrofolate ligase family
A4G25_RS00840	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A4G25_RS00845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4G25_RS00850	COG0204	Acyl-transferase
A4G25_RS00865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A4G25_RS00875	COG1764	response to oxidative stress
A4G25_RS00880	COG0584	glycerophosphoryl diester phosphodiesterase
A4G25_RS00885	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A4G25_RS00890	COG1956	GAF domain-containing protein
A4G25_RS00895	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
A4G25_RS00900	COG1104	cysteine desulfurase activity
A4G25_RS00905	COG0301	tRNA thio-modification
A4G25_RS00915	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A4G25_RS00920	COG0827	DNA restriction-modification system
A4G25_RS00925	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A4G25_RS00930	COG0589	response to stress
A4G25_RS00935	COG0686	Belongs to the AlaDH PNT family
A4G25_RS00940	COG0006	proline dipeptidase activity
A4G25_RS00945	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A4G25_RS00955	COG4109	DRTGG domain
A4G25_RS00960	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A4G25_RS00970	COG0281	malic enzyme
A4G25_RS00975	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A4G25_RS00980	COG0825	malonyl-CoA metabolic process
A4G25_RS00985	COG0205	6-phosphofructokinase activity
A4G25_RS00990	COG0469	pyruvate kinase activity
A4G25_RS00995	COG1113	amino acid transport
A4G25_RS01000	COG0372	Belongs to the citrate synthase family
A4G25_RS01005	COG0538	isocitrate dehydrogenase activity
A4G25_RS01010	COG0745	RESPONSE REGULATOR receiver
A4G25_RS01015	COG5002	protein histidine kinase activity
A4G25_RS01020	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A4G25_RS01020	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A4G25_RS01025	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A4G25_RS01030	COG0237	dephospho-CoA kinase activity
A4G25_RS01040	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A4G25_RS01045	COG3611	Membrane attachment protein
A4G25_RS01050	COG1484	DNA-dependent DNA replication
A4G25_RS01055	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A4G25_RS01060	COG0833	amino acid
A4G25_RS01065	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A4G25_RS01070	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A4G25_RS01075	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A4G25_RS01080	COG4112	unkown
A4G25_RS01090	COG0544	peptidyl-prolyl cis-trans isomerase activity
A4G25_RS01095	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A4G25_RS01100	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A4G25_RS01105	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A4G25_RS01110	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A4G25_RS01115	COG0181	hydroxymethylbilane synthase activity
A4G25_RS01130	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A4G25_RS01135	COG3180	Ammonia monooxygenase
A4G25_RS01140	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
A4G25_RS01145	COG2818	Glycosylase
A4G25_RS01150	COG0525	valine-tRNA ligase activity
A4G25_RS01155	COG0285	dihydrofolate synthase activity
A4G25_RS01160	COG2003	Belongs to the UPF0758 family
A4G25_RS01170	COG1792	Involved in formation and maintenance of cell shape
A4G25_RS01180	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A4G25_RS01185	COG2868	ribosomal protein
A4G25_RS01190	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A4G25_RS01195	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A4G25_RS01200	COG4492	Belongs to the UPF0735 family
A4G25_RS01205	COG0632	four-way junction helicase activity
A4G25_RS01210	COG2255	four-way junction helicase activity
A4G25_RS01215	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A4G25_RS01220	COG0343	queuine tRNA-ribosyltransferase activity
A4G25_RS01225	COG1862	Preprotein translocase
A4G25_RS01230	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4G25_RS01230	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4G25_RS01235	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A4G25_RS01235	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A4G25_RS01240	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A4G25_RS01250	COG1490	D-aminoacyl-tRNA deacylase activity
A4G25_RS01255	COG0860	N-Acetylmuramoyl-L-alanine amidase
A4G25_RS01260	COG0124	histidyl-tRNA synthetase
A4G25_RS01265	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A4G25_RS01275	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A4G25_RS01280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A4G25_RS01285	COG1959	2 iron, 2 sulfur cluster binding
A4G25_RS01290	COG3237	CsbD-like
A4G25_RS01295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4G25_RS01300	COG1104	cysteine desulfurase activity
A4G25_RS01305	COG0482	sulfurtransferase activity
A4G25_RS01315	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A4G25_RS01320	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A4G25_RS01325	COG4472	Bacterial protein of unknown function (DUF965)
A4G25_RS01330	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A4G25_RS01335	COG3906	Belongs to the UPF0473 family
A4G25_RS01340	COG4122	O-methyltransferase activity
A4G25_RS01345	COG0826	peptidase U32
A4G25_RS01350	COG0826	peptidase U32
A4G25_RS01355	COG0572	uridine kinase
A4G25_RS01360	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A4G25_RS01365	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A4G25_RS01370	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
A4G25_RS01375	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A4G25_RS01380	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A4G25_RS01385	COG1534	Rna-binding protein
A4G25_RS01390	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A4G25_RS01395	COG1713	HD superfamily hydrolase involved in NAD metabolism
A4G25_RS01400	COG0799	negative regulation of ribosome biogenesis
A4G25_RS01405	COG2226	methyltransferase
A4G25_RS01410	COG1555	photosystem II stabilization
A4G25_RS01410	COG1596	polysaccharide export
A4G25_RS01415	COG2131	deaminase
A4G25_RS01420	COG2333	competence protein COMEC
A4G25_RS01420	COG0658	competence protein
A4G25_RS01430	COG0268	Binds directly to 16S ribosomal RNA
A4G25_RS01435	COG0481	GTPase activity
A4G25_RS01440	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A4G25_RS01445	COG1420	regulation of RNA biosynthetic process
A4G25_RS01450	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A4G25_RS01455	COG0443	Heat shock 70 kDa protein
A4G25_RS01460	COG0484	heat shock protein binding
A4G25_RS01465	COG2264	protein methyltransferase activity
A4G25_RS01470	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A4G25_RS01475	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A4G25_RS01490	COG4864	UPF0365 protein
A4G25_RS01500	COG1702	phosphate starvation-inducible protein PhoH
A4G25_RS01505	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A4G25_RS01520	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A4G25_RS01525	COG1381	Involved in DNA repair and RecF pathway recombination
A4G25_RS01530	COG0423	glycine-tRNA ligase activity
A4G25_RS01535	COG0517	IMP dehydrogenase activity
A4G25_RS01540	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A4G25_RS01550	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A4G25_RS01555	COG2384	SAM-dependent methyltransferase
A4G25_RS01560	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A4G25_RS01565	COG0513	Belongs to the DEAD box helicase family
A4G25_RS01570	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A4G25_RS01575	COG1121	(ABC) transporter
A4G25_RS01580	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A4G25_RS01605	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A4G25_RS01615	COG4483	Protein conserved in bacteria
A4G25_RS01620	COG1940	carbohydrate kinase activity
A4G25_RS01625	COG0011	TIGRFAM Protein of
A4G25_RS01630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4G25_RS01635	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A4G25_RS01640	COG1459	type II secretion system
A4G25_RS01665	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A4G25_RS01670	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A4G25_RS01675	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A4G25_RS01680	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A4G25_RS01685	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A4G25_RS01690	COG0095	Lipoate-protein ligase
A4G25_RS01705	COG0006	proline dipeptidase activity
A4G25_RS01710	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A4G25_RS01715	COG0511	ligase activity, forming carbon-carbon bonds
A4G25_RS01720	COG0439	Biotin carboxylase
A4G25_RS01730	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A4G25_RS01735	COG1570	exodeoxyribonuclease VII activity
A4G25_RS01740	COG1722	exodeoxyribonuclease VII activity
A4G25_RS01750	COG1438	arginine binding
A4G25_RS01755	COG0497	DNA recombination
A4G25_RS01760	COG0280	phosphate acetyltransferase
A4G25_RS01765	COG3426	butyrate kinase activity
A4G25_RS01770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A4G25_RS01775	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A4G25_RS01780	COG0022	dehydrogenase e1 component
A4G25_RS01785	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4G25_RS01795	COG4129	membrane
A4G25_RS01800	COG2195	Cleaves the N-terminal amino acid of tripeptides
A4G25_RS01805	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A4G25_RS01815	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A4G25_RS01820	COG1234	tRNA 3'-trailer cleavage
A4G25_RS01825	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A4G25_RS01830	COG1028	Short-chain dehydrogenase reductase Sdr
A4G25_RS01835	COG0667	Aldo Keto reductase
A4G25_RS01840	COG0494	nUDIX hydrolase
A4G25_RS01845	COG0735	belongs to the Fur family
A4G25_RS01850	COG4974	Belongs to the 'phage' integrase family
A4G25_RS01865	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A4G25_RS01870	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A4G25_RS01875	COG1187	pseudouridine synthase activity
A4G25_RS01880	COG0745	RESPONSE REGULATOR receiver
A4G25_RS01895	COG1141	Ferredoxin
A4G25_RS01905	COG0514	ATP-dependent DNA helicase (RecQ)
A4G25_RS01910	COG1388	LysM domain
A4G25_RS01910	COG1388	LysM domain
A4G25_RS01915	COG0492	ferredoxin-NADP+ reductase activity
A4G25_RS01925	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A4G25_RS01930	COG0539	negative regulation of cytoplasmic translation
A4G25_RS01935	COG1160	GTP binding
A4G25_RS01940	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A4G25_RS01955	COG2226	methyltransferase
A4G25_RS01960	COG0142	geranyltranstransferase activity
A4G25_RS01965	COG0105	UTP biosynthetic process
A4G25_RS01970	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A4G25_RS01975	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A4G25_RS01980	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A4G25_RS01985	COG0457	Tetratricopeptide repeat
A4G25_RS01990	COG5582	Belongs to the UPF0302 family
A4G25_RS01995	COG4347	Protein of unknown function (DUF1405)
A4G25_RS02000	COG2738	Putative neutral zinc metallopeptidase
A4G25_RS02005	COG1694	Mazg nucleotide pyrophosphohydrolase
A4G25_RS02010	COG0438	transferase activity, transferring glycosyl groups
A4G25_RS02015	COG0617	tRNA 3'-terminal CCA addition
A4G25_RS02020	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A4G25_RS02020	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A4G25_RS02025	COG1199	ATP-dependent helicase activity
A4G25_RS02025	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A4G25_RS02030	COG0017	Asparaginyl-tRNA synthetase
A4G25_RS02035	COG3935	DnaD domain protein
A4G25_RS02040	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A4G25_RS02050	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A4G25_RS02050	COG4499	WXG100 protein secretion system (Wss), protein YukC
A4G25_RS02055	COG3331	DNA recombination
A4G25_RS02065	COG4474	Belongs to the UPF0398 family
A4G25_RS02070	COG3599	regulation of cell shape
A4G25_RS02080	COG0116	Belongs to the methyltransferase superfamily
A4G25_RS02085	COG2962	Rard protein
A4G25_RS02095	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A4G25_RS02100	COG0328	RNA-DNA hybrid ribonuclease activity
A4G25_RS02105	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A4G25_RS02110	COG1413	lyase activity
A4G25_RS02140	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A4G25_RS02145	COG2190	(PTS) system
A4G25_RS02150	COG4479	Belongs to the UPF0346 family
A4G25_RS02155	COG0793	Belongs to the peptidase S41A family
A4G25_RS02165	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A4G25_RS02170	COG0671	phosphoesterase, PA-phosphatase related
A4G25_RS02180	COG0745	RESPONSE REGULATOR receiver
A4G25_RS02185	COG5002	protein histidine kinase activity
A4G25_RS02190	COG0567	Dehydrogenase, E1 component
A4G25_RS02215	COG0714	Associated with various cellular activities
A4G25_RS02220	COG4548	von Willebrand factor, type A
A4G25_RS02225	COG1114	Component of the transport system for branched-chain amino acids
A4G25_RS02230	COG1597	lipid kinase activity
A4G25_RS02235	COG3853	Toxic anion resistance protein (TelA)
A4G25_RS02270	COG1473	amidohydrolase
A4G25_RS02275	COG2171	N-acyltransferase activity
A4G25_RS02280	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A4G25_RS02285	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4G25_RS02290	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A4G25_RS02295	COG0527	aspartate kinase activity
A4G25_RS02300	COG0488	(ABC) transporter
A4G25_RS02305	COG2996	Protein conserved in bacteria
A4G25_RS02310	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A4G25_RS02315	COG0573	inorganic phosphate transmembrane transporter activity
A4G25_RS02320	COG0581	inorganic phosphate transmembrane transporter activity
A4G25_RS02325	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A4G25_RS02330	COG0704	Plays a role in the regulation of phosphate uptake
A4G25_RS02335	COG1164	Oligoendopeptidase f
A4G25_RS02345	COG0747	negative chemotaxis
A4G25_RS02380	COG2348	transferase activity, transferring amino-acyl groups
A4G25_RS02385	COG0159	tryptophan synthase activity
A4G25_RS02395	COG0135	phosphoribosylanthranilate isomerase activity
A4G25_RS02400	COG0134	indole-3-glycerol-phosphate synthase activity
A4G25_RS02405	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A4G25_RS02415	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A4G25_RS02420	COG1363	Peptidase, m42
A4G25_RS02425	COG0287	Prephenate dehydrogenase
A4G25_RS02430	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A4G25_RS02450	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
A4G25_RS02465	COG0628	permease
A4G25_RS02470	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4G25_RS02470	COG1263	PTS System
A4G25_RS02470	COG2190	(PTS) system
A4G25_RS02475	COG2190	(PTS) system
A4G25_RS02475	COG1263	PTS System
A4G25_RS02475	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4G25_RS02480	COG3711	transcriptional antiterminator
A4G25_RS02485	COG1115	amino acid carrier protein
A4G25_RS02490	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A4G25_RS02500	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A4G25_RS02505	COG4841	protein insertion into membrane
A4G25_RS02510	COG0824	Thioesterase
A4G25_RS02515	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A4G25_RS02520	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A4G25_RS02525	COG1970	mechanosensitive ion channel activity
A4G25_RS02535	COG0420	3'-5' exonuclease activity
A4G25_RS02540	COG4846	Membrane protein involved in cytochrome C biogenesis
A4G25_RS02545	COG3763	UPF0154 protein
A4G25_RS02550	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A4G25_RS02555	COG4224	UPF0291 protein
A4G25_RS02565	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A4G25_RS02570	COG2340	Cysteine-rich secretory protein family
A4G25_RS02575	COG0516	GMP reductase activity
A4G25_RS02580	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A4G25_RS02590	COG0833	amino acid
A4G25_RS02600	COG0561	phosphatase activity
A4G25_RS02605	COG0083	homoserine kinase activity
A4G25_RS02610	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A4G25_RS02615	COG0460	homoserine dehydrogenase
A4G25_RS02620	COG0527	aspartate kinase activity
A4G25_RS02645	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
A4G25_RS02650	COG1525	nuclease
A4G25_RS02660	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A4G25_RS02670	COG0789	Transcriptional regulator
A4G25_RS02685	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
A4G25_RS02690	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A4G25_RS02700	COG1923	regulation of RNA biosynthetic process
A4G25_RS02705	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A4G25_RS02710	COG2267	carboxylic ester hydrolase activity
A4G25_RS02715	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A4G25_RS02720	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A4G25_RS02725	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A4G25_RS02735	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A4G25_RS02740	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A4G25_RS02745	COG0584	glycerophosphoryl diester phosphodiesterase
A4G25_RS02755	COG4550	Control of competence regulator ComK, YlbF/YmcA
A4G25_RS02760	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A4G25_RS02775	COG1013	pyruvate-flavodoxin oxidoreductase activity
A4G25_RS02780	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A4G25_RS02780	COG0674	pyruvate-flavodoxin oxidoreductase activity
A4G25_RS02785	COG1692	metallophosphoesterase
A4G25_RS02795	COG0583	DNA-binding transcription factor activity
A4G25_RS02805	COG1418	mRNA catabolic process
A4G25_RS02810	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A4G25_RS02815	COG1058	Belongs to the CinA family
A4G25_RS02815	COG1546	Belongs to the CinA family
A4G25_RS02835	COG0300	oxidoreductase activity
A4G25_RS02840	COG0612	Peptidase, M16
A4G25_RS02850	COG2188	Transcriptional regulator
A4G25_RS02860	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A4G25_RS02865	COG1185	polyribonucleotide nucleotidyltransferase activity
A4G25_RS02870	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A4G25_RS02875	COG0196	riboflavin kinase activity
A4G25_RS02880	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A4G25_RS02885	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A4G25_RS02905	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A4G25_RS02910	COG1358	cellular component organization or biogenesis
A4G25_RS02915	COG2740	Nucleic-acid-binding protein implicated in transcription termination
A4G25_RS02920	COG0195	Participates in both transcription termination and antitermination
A4G25_RS02925	COG0779	Required for maturation of 30S ribosomal subunits
A4G25_RS02930	COG2176	DNA-directed DNA polymerase activity
A4G25_RS02940	COG0442	prolyl-tRNA aminoacylation
A4G25_RS02950	COG4589	Belongs to the CDS family
A4G25_RS02960	COG0233	cytoplasmic translational termination
A4G25_RS02965	COG0528	UMP kinase activity
A4G25_RS02970	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A4G25_RS02975	COG0052	Belongs to the universal ribosomal protein uS2 family
A4G25_RS02980	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
A4G25_RS02985	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A4G25_RS02990	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A4G25_RS02995	COG4974	Belongs to the 'phage' integrase family
A4G25_RS03005	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A4G25_RS03015	COG0045	succinate-CoA ligase (ADP-forming) activity
A4G25_RS03020	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A4G25_RS03040	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
A4G25_RS03045	COG4485	Bacterial membrane protein, YfhO
A4G25_RS03055	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A4G25_RS03055	COG4932	domain protein
A4G25_RS03055	COG3583	domain protein
A4G25_RS03060	COG0335	large ribosomal subunit rRNA binding
A4G25_RS03065	COG0336	Belongs to the RNA methyltransferase TrmD family
A4G25_RS03070	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A4G25_RS03075	COG0228	four-way junction DNA binding
A4G25_RS03085	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A4G25_RS03090	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
A4G25_RS03095	COG0552	protein localization to endoplasmic reticulum
A4G25_RS03100	COG1196	nuclear chromosome segregation
A4G25_RS03105	COG0571	ribonuclease III activity
A4G25_RS03110	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4G25_RS03125	COG0416	fatty acid biosynthetic process
A4G25_RS03130	COG1349	DNA-binding transcription factor activity
A4G25_RS03135	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A4G25_RS03140	COG1760	l-serine dehydratase
A4G25_RS03145	COG1760	l-serine dehydratase
A4G25_RS03150	COG1461	Dihydroxyacetone kinase
A4G25_RS03155	COG1302	Protein conserved in bacteria
A4G25_RS03160	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A4G25_RS03175	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A4G25_RS03180	COG1162	GTPase activity
A4G25_RS03190	COG0631	protein serine/threonine phosphatase activity
A4G25_RS03195	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A4G25_RS03200	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A4G25_RS03200	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A4G25_RS03205	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A4G25_RS03230	COG2910	NAD(P)H-binding
A4G25_RS03235	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A4G25_RS03240	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A4G25_RS03250	COG1758	RNA polymerase activity
A4G25_RS03255	COG0194	GDP metabolic process
A4G25_RS03285	COG0284	orotidine-5'-phosphate decarboxylase activity
A4G25_RS03290	COG0167	dihydroorotate dehydrogenase activity
A4G25_RS03295	COG0543	2 iron, 2 sulfur cluster binding
A4G25_RS03300	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A4G25_RS03305	COG0505	Belongs to the CarA family
A4G25_RS03315	COG0540	Belongs to the ATCase OTCase family
A4G25_RS03320	COG2233	PERMEase
A4G25_RS03325	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A4G25_RS03330	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A4G25_RS03345	COG0564	pseudouridine synthase activity
A4G25_RS03350	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A4G25_RS03355	COG3942	CHAP domain
A4G25_RS03360	COG2514	catechol 2,3-dioxygenase activity
A4G25_RS03365	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A4G25_RS03370	COG3599	regulation of cell shape
A4G25_RS03380	COG0762	integral membrane protein
A4G25_RS03385	COG1799	cell septum assembly
A4G25_RS03390	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A4G25_RS03395	COG1496	oxidoreductase activity
A4G25_RS03405	COG0849	cell division
A4G25_RS03410	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A4G25_RS03415	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A4G25_RS03420	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A4G25_RS03425	COG0768	penicillin binding
A4G25_RS03430	COG4839	cell division protein FtsL
A4G25_RS03435	COG0275	rRNA processing
A4G25_RS03440	COG2001	Belongs to the MraZ family
A4G25_RS03445	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
A4G25_RS03450	COG0454	-acetyltransferase
A4G25_RS03455	COG1011	Hydrolase
A4G25_RS03485	COG1388	LysM domain
A4G25_RS03485	COG5632	N-Acetylmuramoyl-L-alanine amidase
A4G25_RS03710	COG0305	Participates in initiation and elongation during chromosome replication
A4G25_RS03810	COG1045	serine acetyltransferase
A4G25_RS03835	COG2153	protein acetylation
A4G25_RS03860	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A4G25_RS03865	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A4G25_RS03880	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A4G25_RS03885	COG1053	succinate dehydrogenase
A4G25_RS03890	COG2009	succinate dehydrogenase
A4G25_RS03895	COG0322	excinuclease ABC activity
A4G25_RS03900	COG3118	belongs to the thioredoxin family
A4G25_RS03905	COG1193	negative regulation of DNA recombination
A4G25_RS03910	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A4G25_RS03910	COG1796	DNA polymerase
A4G25_RS03925	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A4G25_RS03930	COG0072	phenylalanine-tRNA ligase activity
A4G25_RS03930	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4G25_RS03935	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A4G25_RS03940	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4G25_RS03945	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A4G25_RS03955	COG1323	Belongs to the UPF0348 family
A4G25_RS03965	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A4G25_RS03970	COG0742	ribosomal rna small subunit methyltransferase
A4G25_RS03980	COG4471	UPF0298 protein
A4G25_RS03985	COG0584	glycerophosphoryl diester phosphodiesterase
A4G25_RS03990	COG3679	Belongs to the UPF0342 family
A4G25_RS04005	COG0109	protoheme IX farnesyltransferase activity
A4G25_RS04010	COG1612	heme a metabolic process
A4G25_RS04020	COG0772	Belongs to the SEDS family
A4G25_RS04025	COG4838	Belongs to the UPF0358 family
A4G25_RS04030	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A4G25_RS04040	COG1217	gtp-binding protein TYPA
A4G25_RS04050	COG0483	inositol monophosphate 1-phosphatase activity
A4G25_RS04055	COG4493	Belongs to the UPF0637 family
A4G25_RS04060	COG1914	H( )-stimulated, divalent metal cation uptake system
A4G25_RS04080	COG1177	transmembrane transport
A4G25_RS04085	COG1176	ABC-type spermidine putrescine transport system, permease component I
A4G25_RS04090	COG3842	ATPase activity
A4G25_RS04100	COG4476	Belongs to the UPF0223 family
A4G25_RS04115	COG0022	dehydrogenase e1 component
A4G25_RS04130	COG0242	peptide deformylase activity
A4G25_RS04140	COG5503	Protein of unknown function (DUF1447)
A4G25_RS04150	COG0569	domain protein
A4G25_RS04155	COG1294	oxidase, subunit
A4G25_RS04160	COG1271	oxidase subunit
A4G25_RS04170	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A4G25_RS04185	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A4G25_RS04200	COG1122	ATPase activity
A4G25_RS04205	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A4G25_RS04215	COG0151	Belongs to the GarS family
A4G25_RS04220	COG0138	bifunctional purine biosynthesis protein purh
A4G25_RS04225	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A4G25_RS04230	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A4G25_RS04235	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A4G25_RS04240	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A4G25_RS04245	COG0047	phosphoribosylformylglycinamidine synthase activity
A4G25_RS04255	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A4G25_RS04260	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A4G25_RS04265	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A4G25_RS04270	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A4G25_RS04275	COG1363	Peptidase, m42
A4G25_RS04285	COG1017	nitric oxide dioxygenase activity
A4G25_RS04285	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A4G25_RS04295	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A4G25_RS04305	COG1845	cytochrome c oxidase, subunit III
A4G25_RS04310	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A4G25_RS04320	COG1349	DNA-binding transcription factor activity
A4G25_RS04330	COG0698	ribose 5-phosphate isomerase
A4G25_RS04335	COG1105	Belongs to the carbohydrate kinase PfkB family
A4G25_RS04345	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A4G25_RS04350	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A4G25_RS04355	COG2723	6-phospho-beta-galactosidase activity
A4G25_RS04360	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A4G25_RS04360	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A4G25_RS04365	COG5632	N-Acetylmuramoyl-L-alanine amidase
A4G25_RS04365	COG1388	LysM domain
A4G25_RS04485	COG0052	Belongs to the universal ribosomal protein uS2 family
A4G25_RS04495	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A4G25_RS04500	COG2369	cell adhesion
A4G25_RS04595	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A4G25_RS04595	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A4G25_RS04600	COG1447	Phosphotransferase system cellobiose-specific component IIA
A4G25_RS04615	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A4G25_RS04620	COG1316	TRANSCRIPTIONal
A4G25_RS04645	COG3594	Acyltransferase
A4G25_RS04650	COG0436	Aminotransferase
A4G25_RS04655	COG1846	Transcriptional regulator
A4G25_RS04660	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A4G25_RS04670	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A4G25_RS04675	COG1169	isochorismate synthase
A4G25_RS04680	COG1575	Belongs to the MenA family. Type 1 subfamily
A4G25_RS04690	COG2314	TM2 domain
A4G25_RS04705	COG4873	Protein conserved in bacteria
A4G25_RS04735	COG3177	Filamentation induced by cAMP protein fic
A4G25_RS04745	COG2267	carboxylic ester hydrolase activity
A4G25_RS04755	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A4G25_RS04765	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A4G25_RS04770	COG0131	Imidazoleglycerol-phosphate dehydratase
A4G25_RS04785	COG0107	imidazoleglycerol-phosphate synthase activity
A4G25_RS04795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A4G25_RS04805	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A4G25_RS04810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4G25_RS04815	COG0861	Integral membrane protein TerC family
A4G25_RS04820	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A4G25_RS04830	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A4G25_RS04835	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A4G25_RS04840	COG2814	Major facilitator Superfamily
A4G25_RS04850	COG2382	esterase
A4G25_RS04855	COG1115	amino acid carrier protein
A4G25_RS04860	COG0628	permease
A4G25_RS04865	COG2814	Major facilitator Superfamily
A4G25_RS04875	COG0569	domain protein
A4G25_RS04875	COG0475	glutathione-regulated potassium exporter activity
A4G25_RS04880	COG2239	Acts as a magnesium transporter
A4G25_RS04885	COG0564	pseudouridine synthase activity
A4G25_RS04890	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A4G25_RS04895	COG2357	RelA SpoT domain protein
A4G25_RS04905	COG4116	CYTH
A4G25_RS04915	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A4G25_RS04930	COG1164	Oligoendopeptidase f
A4G25_RS04935	COG4862	establishment of competence for transformation
A4G25_RS04940	COG1393	Belongs to the ArsC family
A4G25_RS04950	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A4G25_RS04955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4G25_RS04960	COG4166	transmembrane transport
A4G25_RS04965	COG4608	Belongs to the ABC transporter superfamily
A4G25_RS04970	COG0444	Belongs to the ABC transporter superfamily
A4G25_RS04975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4G25_RS04980	COG0601	transmembrane transport
A4G25_RS05000	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4G25_RS05010	COG0542	response to heat
A4G25_RS05020	COG2151	metal-sulfur cluster biosynthetic enzyme
A4G25_RS05025	COG0561	phosphatase activity
A4G25_RS05030	COG0446	pyridine nucleotide-disulphide oxidoreductase
A4G25_RS05040	COG0179	Fumarylacetoacetate (FAA) hydrolase
A4G25_RS05050	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
A4G25_RS05065	COG0398	Pfam SNARE associated Golgi protein
A4G25_RS05075	COG0137	argininosuccinate synthase activity
A4G25_RS05080	COG0165	Argininosuccinate lyase
A4G25_RS05095	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A4G25_RS05100	COG1012	belongs to the aldehyde dehydrogenase family
A4G25_RS05105	COG1902	pentaerythritol trinitrate reductase activity
A4G25_RS05120	COG1098	S1 RNA binding domain
A4G25_RS05125	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A4G25_RS05135	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A4G25_RS05145	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A4G25_RS05145	COG2111	Na H antiporter
A4G25_RS05150	COG2111	Na H antiporter
A4G25_RS05155	COG1006	Multisubunit Na H antiporter MnhC subunit
A4G25_RS05160	COG0651	ATP synthesis coupled electron transport
A4G25_RS05165	COG1863	multisubunit Na H antiporter MnhE subunit
A4G25_RS05170	COG2212	antiporter activity
A4G25_RS05185	COG2050	protein possibly involved in aromatic compounds catabolism
A4G25_RS05190	COG2056	Na+-H+ antiporter family
A4G25_RS05195	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A4G25_RS05200	COG1252	NADH dehydrogenase
A4G25_RS05205	COG0316	Belongs to the HesB IscA family
A4G25_RS05210	COG4844	belongs to the
A4G25_RS05215	COG1252	NADH dehydrogenase
A4G25_RS05225	COG4837	Protein of unknown function (DUF1462)
A4G25_RS05230	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A4G25_RS05235	COG0789	Transcriptional regulator
A4G25_RS05245	COG2217	Heavy metal translocating P-type atpase
A4G25_RS05250	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
A4G25_RS05255	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4G25_RS05260	COG1696	Membrane protein involved in D-alanine export
A4G25_RS05265	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4G25_RS05275	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A4G25_RS05280	COG0647	UMP catabolic process
A4G25_RS05285	COG2445	Protein of unknown function DUF86
A4G25_RS05295	COG4470	Protein conserved in bacteria
A4G25_RS05300	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A4G25_RS05305	COG0737	Belongs to the 5'-nucleotidase family
A4G25_RS05310	COG0730	response to heat
A4G25_RS05315	COG1801	Protein of unknown function DUF72
A4G25_RS05325	COG4536	flavin adenine dinucleotide binding
A4G25_RS05335	COG0464	growth
A4G25_RS05350	COG0719	Fe-S assembly protein
A4G25_RS05355	COG0822	iron-sulfur transferase activity
A4G25_RS05360	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A4G25_RS05365	COG0719	Fe-S assembly protein
A4G25_RS05370	COG0396	ATPase activity
A4G25_RS05375	COG1464	Belongs to the NlpA lipoprotein family
A4G25_RS05380	COG2011	ABC-type metal ion transport system permease component
A4G25_RS05385	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A4G25_RS05390	COG3118	belongs to the thioredoxin family
A4G25_RS05395	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
A4G25_RS05400	COG0509	glycine decarboxylation via glycine cleavage system
A4G25_RS05405	COG1393	Belongs to the ArsC family
A4G25_RS05410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4G25_RS05420	COG0710	3-dehydroquinate dehydratase activity
A4G25_RS05450	COG1704	LemA family
A4G25_RS05455	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A4G25_RS05475	COG1278	Cold shock
A4G25_RS05490	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A4G25_RS05500	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A4G25_RS05505	COG0557	exoribonuclease II activity
A4G25_RS05510	COG1647	Serine aminopeptidase, S33
A4G25_RS05515	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A4G25_RS05525	COG0148	phosphopyruvate hydratase activity
A4G25_RS05540	COG0126	phosphoglycerate kinase activity
A4G25_RS05545	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A4G25_RS05575	COG0740	serine-type endopeptidase activity
A4G25_RS05585	COG1114	Component of the transport system for branched-chain amino acids
A4G25_RS05590	COG2814	Major facilitator Superfamily
A4G25_RS05595	COG1481	regulation of sporulation
A4G25_RS05600	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A4G25_RS05605	COG1660	Displays ATPase and GTPase activities
A4G25_RS05620	COG0110	maltose O-acetyltransferase activity
A4G25_RS05625	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A4G25_RS05630	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
A4G25_RS05655	COG3942	CHAP domain
A4G25_RS05660	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A4G25_RS05665	COG0653	protein targeting
A4G25_RS05670	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A4G25_RS05680	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
A4G25_RS05690	COG1739	Uncharacterized protein family UPF0029
A4G25_RS05695	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A4G25_RS05700	COG2199	diguanylate cyclase activity
A4G25_RS05715	COG2195	Cleaves the N-terminal amino acid of tripeptides
A4G25_RS05720	COG1929	Belongs to the glycerate kinase type-1 family
A4G25_RS05740	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A4G25_RS05755	COG4607	ABC-type enterochelin transport system periplasmic component
A4G25_RS05760	COG4604	ABC transporter, ATP-binding protein
A4G25_RS05765	COG4605	iron ion homeostasis
A4G25_RS05770	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4G25_RS05775	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4G25_RS05780	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4G25_RS05785	COG1780	Probably involved in ribonucleotide reductase function
A4G25_RS05790	COG0697	spore germination
A4G25_RS05795	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A4G25_RS05800	COG3104	oligopeptide transport
A4G25_RS05805	COG3104	oligopeptide transport
A4G25_RS05810	COG2226	methyltransferase
A4G25_RS05820	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A4G25_RS05825	COG1174	glycine betaine transport
A4G25_RS05835	COG0514	ATP-dependent DNA helicase (RecQ)
A4G25_RS05840	COG0488	(ABC) transporter
A4G25_RS05845	COG1368	sulfuric ester hydrolase activity
A4G25_RS05855	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A4G25_RS05865	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A4G25_RS05870	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A4G25_RS05875	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A4G25_RS05875	COG0512	Glutamine amidotransferase of anthranilate synthase
A4G25_RS05880	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A4G25_RS05885	COG0720	synthase
A4G25_RS05890	COG0602	queuosine metabolic process
A4G25_RS05905	COG0656	L-ascorbic acid biosynthetic process
A4G25_RS05910	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
A4G25_RS05935	COG1253	flavin adenine dinucleotide binding
A4G25_RS05940	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4G25_RS05940	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4G25_RS05940	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4G25_RS05945	COG1105	Belongs to the carbohydrate kinase PfkB family
A4G25_RS05950	COG1349	DNA-binding transcription factor activity
A4G25_RS05955	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A4G25_RS05990	COG0471	metal ion transport
A4G25_RS05995	COG0039	L-malate dehydrogenase activity
A4G25_RS06000	COG0586	Pfam SNARE associated Golgi protein
A4G25_RS06015	COG0523	cobalamin synthesis protein
A4G25_RS06025	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A4G25_RS06030	COG4988	ABC transporter
A4G25_RS06035	COG1968	undecaprenyl-diphosphatase activity
A4G25_RS06045	COG1671	Belongs to the UPF0178 family
A4G25_RS06075	COG2839	Protein conserved in bacteria
A4G25_RS06080	COG2814	Major facilitator Superfamily
A4G25_RS06085	COG0583	DNA-binding transcription factor activity
A4G25_RS06100	COG0217	transcriptional regulatory protein
A4G25_RS06120	COG3942	CHAP domain
A4G25_RS06120	COG1388	LysM domain
A4G25_RS06125	COG1733	regulation of RNA biosynthetic process
A4G25_RS06130	COG2814	Major facilitator Superfamily
A4G25_RS06135	COG0656	L-ascorbic acid biosynthetic process
A4G25_RS06140	COG0306	phosphate transporter
A4G25_RS06145	COG1392	Phosphate transport regulator
A4G25_RS06150	COG0577	efflux transmembrane transporter activity
A4G25_RS06155	COG1136	(ABC) transporter
A4G25_RS06175	COG0657	acetylesterase activity
A4G25_RS06180	COG3949	Membrane
A4G25_RS06190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4G25_RS06195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4G25_RS06200	COG1120	ATPase activity
A4G25_RS06205	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A4G25_RS06210	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A4G25_RS06215	COG1132	(ABC) transporter
A4G25_RS06220	COG1686	Belongs to the peptidase S11 family
A4G25_RS06225	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A4G25_RS06235	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A4G25_RS06240	COG1682	transport, permease protein
A4G25_RS06250	COG5609	conserved protein (DUF2294)
A4G25_RS06255	COG3949	Membrane
A4G25_RS06270	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A4G25_RS06280	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
A4G25_RS06285	COG0110	maltose O-acetyltransferase activity
A4G25_RS06295	COG1247	-acetyltransferase
A4G25_RS06305	COG1121	(ABC) transporter
A4G25_RS06310	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A4G25_RS06315	COG0803	Belongs to the bacterial solute-binding protein 9 family
A4G25_RS06320	COG0025	NhaP-type Na H and K H
A4G25_RS06370	COG0546	phosphoglycolate phosphatase activity
A4G25_RS06375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4G25_RS06380	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A4G25_RS06385	COG0018	arginyl-trna synthetase
A4G25_RS06395	COG1473	amidohydrolase
A4G25_RS06425	COG1078	dGTPase activity
A4G25_RS06430	COG0519	Catalyzes the synthesis of GMP from XMP
A4G25_RS06445	COG4844	belongs to the
A4G25_RS06465	COG0095	Lipoate-protein ligase
A4G25_RS06470	COG0280	phosphate acetyltransferase
A4G25_RS06475	COG3253	May function as heme-dependent peroxidase
A4G25_RS06495	COG0586	Pfam SNARE associated Golgi protein
A4G25_RS06500	COG0531	amino acid
A4G25_RS06505	COG2363	Small membrane protein
A4G25_RS06515	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A4G25_RS06525	COG0477	Major facilitator Superfamily
A4G25_RS06530	COG1469	GTP cyclohydrolase I activity
A4G25_RS06535	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A4G25_RS06540	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A4G25_RS06545	COG0363	glucosamine-6-phosphate deaminase activity
A4G25_RS06550	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
A4G25_RS06560	COG0431	NADPH-dependent FMN reductase
A4G25_RS06565	COG0561	phosphatase activity
A4G25_RS06575	COG1428	Deoxynucleoside kinase
A4G25_RS06580	COG1428	Deoxynucleoside kinase
A4G25_RS06585	COG0561	phosphatase activity
A4G25_RS06595	COG0546	phosphoglycolate phosphatase activity
A4G25_RS06600	COG2832	Protein of unknown function (DUF454)
A4G25_RS06605	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A4G25_RS06625	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
A4G25_RS06635	COG1473	amidohydrolase
A4G25_RS06640	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A4G25_RS06645	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A4G25_RS06650	COG0049	tRNA binding
A4G25_RS06655	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A4G25_RS06670	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A4G25_RS06675	COG0085	RNA polymerase activity
A4G25_RS06680	COG2813	Specifically methylates the guanine in position
A4G25_RS06690	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A4G25_RS06695	COG0081	regulation of translation
A4G25_RS06700	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A4G25_RS06705	COG0250	Participates in transcription elongation, termination and antitermination
A4G25_RS06710	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A4G25_RS06725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4G25_RS06730	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
A4G25_RS06735	COG0215	cysteine-tRNA ligase activity
A4G25_RS06740	COG1045	serine acetyltransferase
A4G25_RS06745	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A4G25_RS06750	COG4956	integral membrane protein (PIN domain superfamily)
A4G25_RS06755	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A4G25_RS06760	COG0542	response to heat
A4G25_RS06765	COG3869	Catalyzes the specific phosphorylation of arginine residues in
A4G25_RS06770	COG3880	PFAM UvrB UvrC protein
A4G25_RS06780	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A4G25_RS06795	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
A4G25_RS06800	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
A4G25_RS06805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4G25_RS06815	COG2814	Major facilitator Superfamily
A4G25_RS06900	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A4G25_RS06905	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A4G25_RS06910	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A4G25_RS06915	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A4G25_RS06930	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A4G25_RS06935	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A4G25_RS06950	COG1098	S1 RNA binding domain
A4G25_RS06960	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A4G25_RS06965	COG3956	TIGRFAM MazG family protein
A4G25_RS06970	COG2244	polysaccharide biosynthetic process
A4G25_RS06975	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A4G25_RS06980	COG0193	aminoacyl-tRNA hydrolase activity
A4G25_RS06985	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A4G25_RS06990	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A4G25_RS06995	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A4G25_RS07000	COG2088	sporulation resulting in formation of a cellular spore
A4G25_RS07005	COG0251	oxidation-reduction process
A4G25_RS07010	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A4G25_RS07020	COG4466	Protein conserved in bacteria
A4G25_RS07025	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A4G25_RS07030	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
A4G25_RS07035	COG0084	hydrolase, TatD family'
A4G25_RS07040	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4G25_RS07040	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4G25_RS07070	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A4G25_RS07075	COG2827	Endonuclease containing a URI domain
A4G25_RS07080	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A4G25_RS07085	COG4467	Involved in initiation control of chromosome replication
A4G25_RS07090	COG1774	PSP1 C-terminal conserved region
A4G25_RS07095	COG0470	DNA polymerase III
A4G25_RS07100	COG3870	Protein conserved in bacteria
A4G25_RS07105	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A4G25_RS07110	COG1982	Orn Lys Arg decarboxylase major
A4G25_RS07130	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A4G25_RS07135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A4G25_RS07140	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A4G25_RS07155	COG2814	Major facilitator Superfamily
A4G25_RS07175	COG0640	Transcriptional regulator
A4G25_RS07180	COG2188	Transcriptional regulator
A4G25_RS07185	COG0366	Alpha amylase catalytic
A4G25_RS07190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4G25_RS07190	COG1263	PTS System
A4G25_RS07195	COG0346	lactoylglutathione lyase activity
A4G25_RS07205	COG0493	'glutamate synthase
A4G25_RS07210	COG0070	glutamate synthase
A4G25_RS07210	COG0069	glutamate synthase activity
A4G25_RS07210	COG0067	glutamate synthase
A4G25_RS07215	COG0583	DNA-binding transcription factor activity
A4G25_RS07245	COG4841	protein insertion into membrane
A4G25_RS07250	COG0494	nUDIX hydrolase
A4G25_RS07255	COG4841	protein insertion into membrane
A4G25_RS07265	COG0737	Belongs to the 5'-nucleotidase family
A4G25_RS07280	COG3246	L-lysine catabolic process to acetate
A4G25_RS07285	COG1250	3-hydroxyacyl-CoA dehydrogenase
A4G25_RS07295	COG1279	arginine transmembrane transporter activity
A4G25_RS07300	COG0626	cystathionine gamma-synthase activity
A4G25_RS07305	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A4G25_RS07310	COG0733	neurotransmitter:sodium symporter activity
A4G25_RS07320	COG1647	Serine aminopeptidase, S33
A4G25_RS07325	COG1755	Isoprenylcysteine carboxyl methyltransferase
A4G25_RS07360	COG0346	lactoylglutathione lyase activity
A4G25_RS07375	COG1695	Transcriptional regulator
A4G25_RS07415	COG0529	Catalyzes the synthesis of activated sulfate
A4G25_RS07420	COG2046	Belongs to the sulfate adenylyltransferase family
A4G25_RS07425	COG0730	response to heat
A4G25_RS07430	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A4G25_RS07435	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A4G25_RS07440	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A4G25_RS07445	COG0175	sulfate reduction
A4G25_RS07460	COG1216	Glycosyl transferase, family 2
A4G25_RS07470	COG1131	(ABC) transporter
A4G25_RS07480	COG0535	radical SAM domain protein
A4G25_RS07515	COG1396	sequence-specific DNA binding
A4G25_RS07525	COG0519	Catalyzes the synthesis of GMP from XMP
A4G25_RS07525	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A4G25_RS07530	COG0517	IMP dehydrogenase activity
A4G25_RS07530	COG0516	GMP reductase activity
A4G25_RS07535	COG2233	PERMEase
A4G25_RS07540	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A4G25_RS07565	COG1823	symporter activity
A4G25_RS07570	COG0778	Nitroreductase
A4G25_RS07580	COG0450	alkyl hydroperoxide reductase
A4G25_RS07585	COG3634	alkyl hydroperoxide reductase activity
A4G25_RS07605	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A4G25_RS07610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4G25_RS07630	COG4509	Sortase family
A4G25_RS07665	COG1129	ABC transporter
A4G25_RS07685	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A4G25_RS07695	COG0360	Binds together with S18 to 16S ribosomal RNA
A4G25_RS07715	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A4G25_RS07735	COG0012	GTP binding
A4G25_RS07740	COG4481	Protein conserved in bacteria
A4G25_RS07745	COG0668	transmembrane transport
A4G25_RS07750	COG1475	DNA binding
A4G25_RS07755	COG0626	cystathionine gamma-synthase activity
A4G25_RS07760	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A4G25_RS07760	COG0646	methionine synthase
A4G25_RS07765	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A4G25_RS07775	COG0436	Aminotransferase
A4G25_RS07790	COG1475	DNA binding
A4G25_RS07795	COG0357	Ribosomal RNA small subunit methyltransferase G
A4G25_RS07800	COG0445	tRNA wobble uridine modification
A4G25_RS07805	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A4G25_RS07810	COG0594	ribonuclease P activity
A4G25_RS07820	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A4G25_RS07825	COG0592	DNA-directed DNA polymerase activity
A4G25_RS07835	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A4G25_RS07840	COG0187	DNA topoisomerase II activity
A4G25_RS07850	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A4G25_RS07865	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A4G25_RS07885	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
A4G25_RS07890	COG0359	binds to the 23S rRNA
A4G25_RS07895	COG0305	Participates in initiation and elongation during chromosome replication
A4G25_RS07905	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A4G25_RS07920	COG0745	RESPONSE REGULATOR receiver
A4G25_RS07930	COG4863	YycH protein
A4G25_RS07940	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A4G25_RS07945	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A4G25_RS07965	COG0076	glutamate decarboxylase activity
A4G25_RS07970	COG1686	Belongs to the peptidase S11 family
A4G25_RS07980	COG3711	transcriptional antiterminator
A4G25_RS07980	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4G25_RS07985	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4G25_RS07985	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4G25_RS07985	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4G25_RS07990	COG1482	cell wall glycoprotein biosynthetic process
A4G25_RS08000	COG0640	Transcriptional regulator
A4G25_RS08030	COG1395	domain, Protein
A4G25_RS08045	COG1705	Flagellar rod assembly protein muramidase FlgJ
A4G25_RS08045	COG3942	CHAP domain
A4G25_RS08095	COG0471	metal ion transport
A4G25_RS08100	COG1028	Short-chain dehydrogenase reductase Sdr
A4G25_RS08110	COG1136	(ABC) transporter
A4G25_RS08115	COG4591	ABC-type transport system involved in lipoprotein release permease component
A4G25_RS08150	COG1609	Transcriptional regulator
A4G25_RS08160	COG1869	D-ribose catabolic process
A4G25_RS08175	COG0183	Belongs to the thiolase family
A4G25_RS08185	COG1960	acyl-CoA dehydrogenase activity
A4G25_RS08190	COG0318	PFAM AMP-dependent synthetase and ligase
A4G25_RS08200	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A4G25_RS08210	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A4G25_RS08215	COG1280	lysine exporter protein (LysE YggA)
A4G25_RS08250	COG0598	Magnesium transport protein CorA
A4G25_RS08255	COG0598	Magnesium transport protein CorA
A4G25_RS08265	COG0363	glucosamine-6-phosphate deaminase activity
A4G25_RS08270	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
A4G25_RS08275	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A4G25_RS08275	COG0517	IMP dehydrogenase activity
A4G25_RS08285	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4G25_RS08290	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4G25_RS08305	COG2226	methyltransferase
A4G25_RS08325	COG0778	Nitroreductase
A4G25_RS08350	COG1012	belongs to the aldehyde dehydrogenase family
A4G25_RS08355	COG0531	amino acid
A4G25_RS08360	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A4G25_RS08365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4G25_RS08375	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A4G25_RS08400	COG1028	Short-chain dehydrogenase reductase Sdr
A4G25_RS08410	COG1012	belongs to the aldehyde dehydrogenase family
A4G25_RS08420	COG2851	Citrate transporter
A4G25_RS08460	COG1472	Belongs to the glycosyl hydrolase 3 family
A4G25_RS08465	COG1064	alcohol dehydrogenase
A4G25_RS08475	COG0730	response to heat
A4G25_RS08490	COG0753	catalase activity
A4G25_RS08495	COG1063	alcohol dehydrogenase
A4G25_RS08505	COG0542	response to heat
A4G25_RS08520	COG0446	pyridine nucleotide-disulphide oxidoreductase
A4G25_RS08520	COG1902	pentaerythritol trinitrate reductase activity
A4G25_RS08525	COG0640	Transcriptional regulator
A4G25_RS08555	COG3732	PTS system glucitol sorbitol-specific
A4G25_RS08560	COG3730	PTS system glucitol sorbitol-specific
A4G25_RS08585	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A4G25_RS08620	COG1966	Carbon starvation protein
A4G25_RS08650	COG1054	Belongs to the UPF0176 family
A4G25_RS08670	COG2388	GCN5-related N-acetyl-transferase
A4G25_RS08675	COG0346	lactoylglutathione lyase activity
A4G25_RS08690	COG0789	Transcriptional regulator
A4G25_RS08700	COG0477	Major facilitator Superfamily
A4G25_RS08720	COG0667	Aldo Keto reductase
A4G25_RS08730	COG1028	Short-chain dehydrogenase reductase Sdr
A4G25_RS08735	COG3949	Membrane
A4G25_RS08760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4G25_RS08765	COG1028	Short-chain dehydrogenase reductase Sdr
A4G25_RS08785	COG1288	antiporter activity
A4G25_RS08795	COG3871	stress protein (general stress protein 26)
A4G25_RS08800	COG1929	Belongs to the glycerate kinase type-1 family
A4G25_RS08805	COG1511	domain protein
A4G25_RS08820	COG0604	alcohol dehydrogenase
A4G25_RS08825	COG0300	oxidoreductase activity
A4G25_RS08835	COG0579	oxidoreductase
A4G25_RS08840	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A4G25_RS08855	COG0561	phosphatase activity
A4G25_RS08860	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4G25_RS08865	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A4G25_RS08870	COG1757	Na H antiporter
A4G25_RS08875	COG2326	polyphosphate kinase activity
A4G25_RS08895	COG0596	Alpha beta hydrolase
A4G25_RS08905	COG1288	antiporter activity
A4G25_RS08915	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A4G25_RS08930	COG0706	membrane insertase activity
A4G25_RS08950	COG0583	DNA-binding transcription factor activity
A4G25_RS08955	COG3842	ATPase activity
A4G25_RS08960	COG1840	ABC-type Fe3 transport system, periplasmic component
A4G25_RS08990	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A4G25_RS09005	COG1028	Short-chain dehydrogenase reductase Sdr
A4G25_RS09045	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A4G25_RS09060	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A4G25_RS09065	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A4G25_RS09095	COG0069	glutamate synthase activity
A4G25_RS09100	COG2814	Major facilitator Superfamily
A4G25_RS09105	COG2822	iron ion transport
A4G25_RS09110	COG2837	iron assimilation
A4G25_RS09115	COG0672	)-iron permease
A4G25_RS09120	COG0805	protein transport
A4G25_RS09125	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A4G25_RS09130	COG4336	lyase activity
A4G25_RS09135	COG0753	catalase activity
A4G25_RS09145	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A4G25_RS09175	COG0201	protein transport
A4G25_RS09185	COG1073	alpha beta
A4G25_RS09210	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A4G25_RS09230	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A4G25_RS09230	COG3583	domain protein
A4G25_RS09230	COG4932	domain protein
A4G25_RS09250	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A4G25_RS09255	COG2011	ABC-type metal ion transport system permease component
A4G25_RS09275	COG2207	Transcriptional regulator
A4G25_RS09295	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A4G25_RS09300	COG1063	alcohol dehydrogenase
A4G25_RS09305	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A4G25_RS09315	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A4G25_RS09325	COG1511	domain protein
A4G25_RS09360	COG2210	Belongs to the sulfur carrier protein TusA family
A4G25_RS09380	COG3961	Belongs to the TPP enzyme family
A4G25_RS09390	COG1510	regulation of RNA biosynthetic process
A4G25_RS09395	COG1012	belongs to the aldehyde dehydrogenase family
A4G25_RS09400	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
A4G25_RS09405	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
A4G25_RS09405	COG4932	domain protein
A4G25_RS09405	COG3266	domain, Protein
A4G25_RS09405	COG3266	domain, Protein
A4G25_RS09405	COG4932	domain protein
A4G25_RS09405	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
A4G25_RS09410	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A4G25_RS09415	COG1181	Belongs to the D-alanine--D-alanine ligase family
A4G25_RS09445	COG1368	sulfuric ester hydrolase activity
A4G25_RS09455	COG2409	Drug exporters of the RND superfamily
A4G25_RS09460	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A4G25_RS09460	COG0463	Glycosyl transferase, family 2
A4G25_RS09470	COG0494	nUDIX hydrolase
A4G25_RS09485	COG3588	fructose-bisphosphate aldolase
A4G25_RS09490	COG2258	MOSC domain
A4G25_RS09515	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A4G25_RS09520	COG1263	PTS System
A4G25_RS09520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4G25_RS09525	COG1737	Transcriptional regulator
A4G25_RS09560	COG0582	viral genome integration into host DNA
A4G25_RS09565	COG2111	Na H antiporter
A4G25_RS09565	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A4G25_RS09570	COG2111	Na H antiporter
A4G25_RS09575	COG1006	Multisubunit Na H antiporter MnhC subunit
A4G25_RS09585	COG1863	multisubunit Na H antiporter MnhE subunit
A4G25_RS09590	COG2212	antiporter activity
A4G25_RS09595	COG1320	monovalent cation:proton antiporter activity
A4G25_RS09610	COG1113	amino acid transport
A4G25_RS09620	COG1131	(ABC) transporter
A4G25_RS09630	COG2824	Alkylphosphonate utilization operon protein PhnA
A4G25_RS09640	COG2376	Dihydroxyacetone kinase
A4G25_RS09645	COG1461	Dihydroxyacetone kinase
A4G25_RS09655	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A4G25_RS09660	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A4G25_RS09665	COG0438	transferase activity, transferring glycosyl groups
A4G25_RS09675	COG0438	transferase activity, transferring glycosyl groups
A4G25_RS09680	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A4G25_RS09680	COG0463	Glycosyl transferase, family 2
A4G25_RS09685	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A4G25_RS09690	COG0531	amino acid
A4G25_RS09715	COG0463	Glycosyl transferase, family 2
A4G25_RS09720	COG0446	pyridine nucleotide-disulphide oxidoreductase
A4G25_RS09730	COG1959	2 iron, 2 sulfur cluster binding
A4G25_RS09735	COG1131	(ABC) transporter
A4G25_RS09750	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A4G25_RS09770	COG0318	PFAM AMP-dependent synthetase and ligase
A4G25_RS09785	COG2235	arginine
A4G25_RS09790	COG2235	arginine
A4G25_RS09800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A4G25_RS09805	COG1438	arginine binding
A4G25_RS09815	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A4G25_RS09820	COG2022	thiamine diphosphate biosynthetic process
A4G25_RS09830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4G25_RS09835	COG0352	thiamine-phosphate diphosphorylase activity
A4G25_RS09845	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
A4G25_RS09850	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A4G25_RS09855	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A4G25_RS09875	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A4G25_RS09890	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4G25_RS09900	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4G25_RS09905	COG2807	transmembrane transport
A4G25_RS09910	COG5646	InterPro IPR014922
A4G25_RS09925	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A4G25_RS09930	COG1984	allophanate hydrolase subunit 2
A4G25_RS09940	COG0439	Biotin carboxylase
A4G25_RS09945	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A4G25_RS09950	COG1914	H( )-stimulated, divalent metal cation uptake system
A4G25_RS09955	COG1070	Carbohydrate kinase
A4G25_RS09970	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A4G25_RS09980	COG1695	Transcriptional regulator
A4G25_RS10020	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A4G25_RS10035	COG3189	MarR family transcriptional regulator
A4G25_RS10045	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A4G25_RS10060	COG0604	alcohol dehydrogenase
A4G25_RS10065	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
A4G25_RS10070	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A4G25_RS10080	COG3001	Fructosamine kinase
A4G25_RS10095	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A4G25_RS10110	COG3764	Sortase (surface protein transpeptidase)
A4G25_RS10115	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A4G25_RS10150	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A4G25_RS10170	COG1136	(ABC) transporter
A4G25_RS10175	COG0577	efflux transmembrane transporter activity
A4G25_RS10180	COG0583	DNA-binding transcription factor activity
A4G25_RS10195	COG0028	Belongs to the TPP enzyme family
A4G25_RS10205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4G25_RS10215	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A4G25_RS10220	COG1687	branched-chain amino acid
A4G25_RS10225	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
A4G25_RS10250	COG1760	l-serine dehydratase
A4G25_RS10255	COG1760	l-serine dehydratase
A4G25_RS10270	COG0778	Nitroreductase
A4G25_RS10280	COG1132	(ABC) transporter
A4G25_RS10285	COG1132	(ABC) transporter
A4G25_RS10295	COG0803	Belongs to the bacterial solute-binding protein 9 family
A4G25_RS10300	COG1846	Transcriptional regulator
A4G25_RS10305	COG0346	lactoylglutathione lyase activity
A4G25_RS10310	COG2211	Major facilitator Superfamily
A4G25_RS10315	COG2207	Transcriptional regulator
A4G25_RS10320	COG3250	beta-galactosidase activity
A4G25_RS10325	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
A4G25_RS10330	COG1131	(ABC) transporter
A4G25_RS10340	COG0586	Pfam SNARE associated Golgi protein
A4G25_RS10345	COG2271	Major facilitator Superfamily
A4G25_RS10350	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
A4G25_RS10355	COG3527	Alpha-acetolactate decarboxylase
A4G25_RS10365	COG4876	unkown
A4G25_RS10370	COG0523	cobalamin synthesis protein
A4G25_RS10375	COG2357	RelA SpoT domain protein
A4G25_RS10390	COG2808	Putative FMN-binding domain
A4G25_RS10395	COG1802	Transcriptional regulator
A4G25_RS10400	COG1070	Carbohydrate kinase
A4G25_RS10405	COG2610	gluconate transmembrane transporter activity
A4G25_RS10415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4G25_RS10420	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A4G25_RS10445	COG4619	ABC transporter
A4G25_RS10450	COG0390	transport system, permease component
A4G25_RS10455	COG2814	Major facilitator Superfamily
A4G25_RS10460	COG2272	Belongs to the type-B carboxylesterase lipase family
A4G25_RS10465	COG0531	amino acid
A4G25_RS10470	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
A4G25_RS10480	COG1174	glycine betaine transport
A4G25_RS10490	COG1174	glycine betaine transport
A4G25_RS10500	COG1309	transcriptional regulator
A4G25_RS10515	COG1346	cytolysis
A4G25_RS10525	COG3279	Response regulator of the LytR AlgR family
A4G25_RS10530	COG3275	phosphorelay sensor kinase activity
A4G25_RS10545	COG0531	amino acid
A4G25_RS10550	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
A4G25_RS10555	COG1113	amino acid transport
A4G25_RS10565	COG2814	Major facilitator Superfamily
A4G25_RS10575	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A4G25_RS10580	COG0741	lytic transglycosylase activity
A4G25_RS10585	COG0588	phosphoglycerate mutase activity
A4G25_RS10590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4G25_RS10595	COG0765	amino acid transport
A4G25_RS10600	COG1126	abc transporter atp-binding protein
A4G25_RS10640	COG2116	formate transmembrane transporter activity
A4G25_RS10655	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A4G25_RS10660	COG2146	nitrite reductase [NAD(P)H] activity
A4G25_RS10665	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A4G25_RS10665	COG1648	precorrin-2 dehydrogenase activity
A4G25_RS10670	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
A4G25_RS10675	COG1140	nitrate reductase beta subunit
A4G25_RS10685	COG2181	nitrate reductase activity
A4G25_RS10695	COG4585	Histidine kinase
A4G25_RS10700	COG2197	response regulator
A4G25_RS10705	COG2223	nitrite transmembrane transporter activity
A4G25_RS10710	COG3425	synthase
A4G25_RS10730	COG1846	Transcriptional regulator
A4G25_RS10755	COG1611	Belongs to the LOG family
A4G25_RS10775	COG0492	ferredoxin-NADP+ reductase activity
A4G25_RS10780	COG2814	Major facilitator Superfamily
A4G25_RS10785	COG0604	alcohol dehydrogenase
A4G25_RS10795	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A4G25_RS10800	COG1620	l-lactate permease
A4G25_RS10805	COG0438	transferase activity, transferring glycosyl groups
A4G25_RS10815	COG5002	protein histidine kinase activity
A4G25_RS10815	COG3850	Histidine kinase
A4G25_RS10820	COG0745	RESPONSE REGULATOR receiver
A4G25_RS10825	COG0577	efflux transmembrane transporter activity
A4G25_RS10830	COG1136	(ABC) transporter
A4G25_RS10850	COG2814	Major facilitator Superfamily
A4G25_RS10855	COG1033	growth of symbiont in host cell
A4G25_RS10855	COG2409	Drug exporters of the RND superfamily
A4G25_RS10865	COG1566	PFAM secretion protein HlyD family protein
A4G25_RS10870	COG2814	Major facilitator Superfamily
A4G25_RS10890	COG0598	Magnesium transport protein CorA
A4G25_RS10895	COG1304	FMN binding
A4G25_RS10905	COG1328	CTP reductase activity
A4G25_RS10910	COG0602	queuosine metabolic process
A4G25_RS10915	COG2094	Belongs to the DNA glycosylase MPG family
A4G25_RS10920	COG3152	Membrane
A4G25_RS10945	COG4152	abc transporter atp-binding protein
A4G25_RS10950	COG1668	transmembrane transport
A4G25_RS10955	COG1742	UPF0060 membrane protein
A4G25_RS10960	COG2017	converts alpha-aldose to the beta-anomer
A4G25_RS10965	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A4G25_RS10970	COG1266	CAAX protease self-immunity
A4G25_RS10975	COG0010	Belongs to the arginase family
A4G25_RS10980	COG0583	DNA-binding transcription factor activity
A4G25_RS10985	COG3314	Sporulation integral membrane protein YlbJ
A4G25_RS10995	COG1228	amidohydrolase
A4G25_RS11000	COG0659	secondary active sulfate transmembrane transporter activity
A4G25_RS11005	COG1473	amidohydrolase
A4G25_RS11010	COG1028	Short-chain dehydrogenase reductase Sdr
A4G25_RS11015	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A4G25_RS11030	COG2271	Major facilitator Superfamily
A4G25_RS11050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4G25_RS11075	COG1113	amino acid transport
A4G25_RS11080	COG1737	Transcriptional regulator
A4G25_RS11105	COG1316	TRANSCRIPTIONal
A4G25_RS11115	COG3383	formate dehydrogenase (NAD+) activity
A4G25_RS11140	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A4G25_RS11145	COG2076	Multidrug Resistance protein
A4G25_RS11150	COG2076	Multidrug Resistance protein
A4G25_RS11165	COG1757	Na H antiporter
A4G25_RS11175	COG3942	CHAP domain
A4G25_RS11195	COG0829	nickel cation binding
A4G25_RS11205	COG0830	nickel cation binding
A4G25_RS11210	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
A4G25_RS11215	COG0804	urea catabolic process
A4G25_RS11220	COG0832	Belongs to the urease beta subunit family
A4G25_RS11225	COG0831	urea catabolic process
A4G25_RS11235	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A4G25_RS11240	COG1960	acyl-CoA dehydrogenase activity
A4G25_RS11245	COG1957	nucleoside hydrolase
A4G25_RS11250	COG1268	BioY protein
A4G25_RS11260	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A4G25_RS11265	COG1609	Transcriptional regulator
A4G25_RS11270	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A4G25_RS11275	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A4G25_RS11280	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
A4G25_RS11285	COG0725	ABC transporter, periplasmic molybdate-binding protein
A4G25_RS11290	COG4149	molybdate abc transporter
A4G25_RS11295	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A4G25_RS11300	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A4G25_RS11305	COG0521	Mo-molybdopterin cofactor biosynthetic process
A4G25_RS11310	COG0315	cyclic pyranopterin monophosphate synthase activity
A4G25_RS11315	COG0303	'Molybdopterin
A4G25_RS11325	COG0314	molybdopterin synthase activity
A4G25_RS11335	COG0746	molybdenum cofactor guanylyltransferase activity
A4G25_RS11340	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A4G25_RS11355	COG2814	Major facilitator Superfamily
A4G25_RS11375	COG2348	transferase activity, transferring amino-acyl groups
A4G25_RS11380	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A4G25_RS11410	COG4975	Glucose uptake
A4G25_RS11420	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A4G25_RS11420	COG0551	DNA topoisomerase type I activity
A4G25_RS11425	COG2252	PERMEase
A4G25_RS11440	COG0051	transcription antitermination factor activity, RNA binding
A4G25_RS11445	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A4G25_RS11450	COG0088	Forms part of the polypeptide exit tunnel
A4G25_RS11455	COG0089	rRNA binding
A4G25_RS11460	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A4G25_RS11465	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A4G25_RS11470	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A4G25_RS11475	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A4G25_RS11480	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A4G25_RS11490	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A4G25_RS11495	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A4G25_RS11500	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A4G25_RS11505	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A4G25_RS11510	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A4G25_RS11515	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A4G25_RS11520	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A4G25_RS11525	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A4G25_RS11530	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A4G25_RS11535	COG1841	ribosomal large subunit assembly
A4G25_RS11540	COG0200	Binds to the 23S rRNA
A4G25_RS11545	COG0201	protein transport
A4G25_RS11550	COG0563	adenylate kinase activity
A4G25_RS11560	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A4G25_RS11565	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A4G25_RS11570	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A4G25_RS11575	COG0202	RNA polymerase activity
A4G25_RS11580	COG0203	ribosomal protein L17
A4G25_RS11600	COG0101	tRNA pseudouridine synthase activity
A4G25_RS11605	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A4G25_RS11610	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A4G25_RS11625	COG1335	isochorismatase
A4G25_RS11650	COG2318	DinB family
A4G25_RS11655	COG0574	Belongs to the PEP-utilizing enzyme family
A4G25_RS11655	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A4G25_RS11660	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A4G25_RS11665	COG2130	NADP-dependent
A4G25_RS11675	COG2130	NADP-dependent
A4G25_RS11680	COG0604	alcohol dehydrogenase
A4G25_RS11685	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A4G25_RS11700	COG1302	Protein conserved in bacteria
A4G25_RS11710	COG2814	Major facilitator Superfamily
A4G25_RS11715	COG4264	IucA IucC family
A4G25_RS11720	COG3457	Alanine racemase
A4G25_RS11725	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
A4G25_RS11730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4G25_RS11735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4G25_RS11740	COG3314	Sporulation integral membrane protein YlbJ
A4G25_RS11745	COG2329	Antibiotic biosynthesis monooxygenase
A4G25_RS11760	COG1988	membrane-bound metal-dependent
A4G25_RS11765	COG4284	Utp--glucose-1-phosphate uridylyltransferase
A4G25_RS11770	COG1272	protein, Hemolysin III
A4G25_RS11785	COG2814	Major facilitator Superfamily
A4G25_RS11790	COG0489	protein tyrosine kinase activity
A4G25_RS11840	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A4G25_RS11845	COG4856	YbbR-like protein
A4G25_RS11850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A4G25_RS11855	COG1285	pathogenesis
A4G25_RS11860	COG0246	Mannitol dehydrogenase
A4G25_RS11865	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4G25_RS11870	COG3711	transcriptional antiterminator
A4G25_RS11905	COG0640	Transcriptional regulator
A4G25_RS11910	COG0702	epimerase
A4G25_RS11915	COG0702	epimerase
A4G25_RS11920	COG2186	Transcriptional regulator
A4G25_RS11925	COG1482	cell wall glycoprotein biosynthetic process
A4G25_RS11945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4G25_RS11950	COG0783	Belongs to the Dps family
A4G25_RS11955	COG1876	peptidase activity
A4G25_RS11960	COG0813	purine-nucleoside phosphorylase activity
A4G25_RS11965	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A4G25_RS11970	COG2348	transferase activity, transferring amino-acyl groups
A4G25_RS11980	COG1854	S-ribosylhomocysteine lyase activity
A4G25_RS11995	COG5146	pantothenate kinase activity
A4G25_RS12005	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4G25_RS12010	COG3343	RNA polymerase activity
A4G25_RS12015	COG0504	CTP synthase activity
A4G25_RS12025	COG0191	fructose-bisphosphate aldolase activity
A4G25_RS12030	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A4G25_RS12040	COG1012	belongs to the aldehyde dehydrogenase family
A4G25_RS12045	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A4G25_RS12050	COG0254	rRNA binding
A4G25_RS12055	COG1435	thymidine kinase activity
A4G25_RS12060	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A4G25_RS12065	COG2890	protein-(glutamine-N5) methyltransferase activity
A4G25_RS12070	COG0009	L-threonylcarbamoyladenylate synthase
A4G25_RS12075	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A4G25_RS12080	COG4475	Protein of unknown function (DUF436)
A4G25_RS12085	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A4G25_RS12090	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A4G25_RS12095	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A4G25_RS12105	COG0356	it plays a direct role in the translocation of protons across the membrane
A4G25_RS12110	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A4G25_RS12115	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A4G25_RS12120	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A4G25_RS12130	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A4G25_RS12135	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A4G25_RS12140	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A4G25_RS12145	COG4836	Membrane
A4G25_RS12160	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A4G25_RS12170	COG0629	single-stranded DNA binding
A4G25_RS12175	COG1388	LysM domain
A4G25_RS12180	COG1388	LysM domain
A4G25_RS12185	COG1388	LysM domain
A4G25_RS12190	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A4G25_RS12200	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
A4G25_RS12205	COG0352	thiamine-phosphate diphosphorylase activity
A4G25_RS12210	COG0706	membrane insertase activity
A4G25_RS12220	COG1418	mRNA catabolic process
A4G25_RS12230	COG1937	Protein conserved in bacteria
A4G25_RS12245	COG2217	Heavy metal translocating P-type atpase
A4G25_RS12250	COG0772	Belongs to the SEDS family
A4G25_RS12255	COG1181	Belongs to the D-alanine--D-alanine ligase family
A4G25_RS12260	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A4G25_RS12280	COG3402	PFAM membrane-flanked domain
A4G25_RS12285	COG0736	holo-[acyl-carrier-protein] synthase activity
A4G25_RS12290	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A4G25_RS12310	COG2208	phosphoserine phosphatase activity
A4G25_RS12325	COG1191	sigma factor activity
A4G25_RS12330	COG2183	response to ionizing radiation
A4G25_RS12335	COG3091	SprT-like family
A4G25_RS12370	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A4G25_RS12375	COG0473	3-isopropylmalate dehydrogenase activity
A4G25_RS12380	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A4G25_RS12385	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A4G25_RS12390	COG0440	acetolactate synthase activity
A4G25_RS12395	COG0028	Belongs to the TPP enzyme family
A4G25_RS12400	COG0129	dihydroxy-acid dehydratase activity
A4G25_RS12405	COG0802	atpase or kinase
A4G25_RS12410	COG1214	PFAM Peptidase M22, glycoprotease
A4G25_RS12415	COG0456	acetyltransferase
A4G25_RS12420	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A4G25_RS12425	COG0488	(ABC) transporter
A4G25_RS12430	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
A4G25_RS12435	COG0425	Belongs to the sulfur carrier protein TusA family
A4G25_RS12440	COG2391	methyltransferase activity
A4G25_RS12445	COG1621	beta-fructofuranosidase activity
A4G25_RS12450	COG3279	Response regulator of the LytR AlgR family
A4G25_RS12465	COG4512	PFAM Accessory gene regulator B
A4G25_RS12490	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A4G25_RS12495	COG0459	protein refolding
A4G25_RS12530	COG1725	Transcriptional regulator
A4G25_RS12545	COG1131	(ABC) transporter
A4G25_RS12590	COG2706	6-phosphogluconolactonase activity
A4G25_RS12595	COG0471	metal ion transport
A4G25_RS12605	COG1335	isochorismatase
A4G25_RS12610	COG1227	inorganic diphosphatase activity
A4G25_RS12615	COG1012	belongs to the aldehyde dehydrogenase family
A4G25_RS12620	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A4G25_RS12625	COG0077	Prephenate dehydratase
A4G25_RS12635	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A4G25_RS12640	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A4G25_RS12645	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
A4G25_RS12650	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A4G25_RS12655	COG4496	protein, YerC YecD
A4G25_RS12660	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
A4G25_RS12670	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A4G25_RS12675	COG4851	CamS sex pheromone cAM373 precursor
A4G25_RS12685	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4G25_RS12690	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A4G25_RS12695	COG0154	amidase activity
A4G25_RS12700	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A4G25_RS12705	COG1597	lipid kinase activity
A4G25_RS12720	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A4G25_RS12740	COG4129	membrane
A4G25_RS12765	COG2197	response regulator